PPDPF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.08454749
2translational termination (GO:0006415)7.62340066
3ribosomal small subunit assembly (GO:0000028)7.39322262
4ribosomal small subunit biogenesis (GO:0042274)6.90087473
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.56439498
6cotranslational protein targeting to membrane (GO:0006613)6.49982422
7protein targeting to ER (GO:0045047)6.45104810
8translational elongation (GO:0006414)6.40532142
9protein localization to endoplasmic reticulum (GO:0070972)6.11026694
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.08877310
11viral life cycle (GO:0019058)6.03320049
12cellular protein complex disassembly (GO:0043624)5.95531025
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.62193846
14maturation of SSU-rRNA (GO:0030490)5.36058085
15protein complex disassembly (GO:0043241)5.30045871
16translational initiation (GO:0006413)5.28248029
17ribosomal large subunit biogenesis (GO:0042273)5.03704238
18macromolecular complex disassembly (GO:0032984)5.01435014
19DNA deamination (GO:0045006)4.86736582
20cell-cell junction maintenance (GO:0045217)4.40666050
21translation (GO:0006412)4.38552994
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.32731187
23ATP synthesis coupled proton transport (GO:0015986)4.32731187
24protein retention in ER lumen (GO:0006621)4.29454679
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27986273
26sequestering of actin monomers (GO:0042989)4.23572628
27negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.20315320
28protein targeting to membrane (GO:0006612)4.20256753
29chaperone-mediated protein transport (GO:0072321)4.14423627
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09980610
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.06613068
32NADH dehydrogenase complex assembly (GO:0010257)4.06613068
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.06613068
34regulation of early endosome to late endosome transport (GO:2000641)4.03416702
35DNA damage response, detection of DNA damage (GO:0042769)3.99918890
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.94417065
37negative regulation of cell size (GO:0045792)3.91114274
38regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85549171
39positive regulation of Cdc42 GTPase activity (GO:0043089)3.85146670
40respiratory electron transport chain (GO:0022904)3.82549100
41protein complex biogenesis (GO:0070271)3.78765785
42electron transport chain (GO:0022900)3.73087622
43proteasome assembly (GO:0043248)3.73038429
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71501374
45mRNA catabolic process (GO:0006402)3.70769760
46GTP biosynthetic process (GO:0006183)3.70039437
47ear development (GO:0043583)3.60770467
48regulation of apoptotic process involved in morphogenesis (GO:1902337)3.59222059
49mitochondrial respiratory chain complex assembly (GO:0033108)3.55536821
50termination of RNA polymerase III transcription (GO:0006386)3.51842682
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.51842682
52desmosome organization (GO:0002934)3.48541163
53adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.46110184
54protein neddylation (GO:0045116)3.43193479
55planar cell polarity pathway involved in neural tube closure (GO:0090179)3.40904880
56cell junction maintenance (GO:0034331)3.40743317
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35529906
58maternal placenta development (GO:0001893)3.35047030
59ribonucleoprotein complex biogenesis (GO:0022613)3.34133058
60RNA catabolic process (GO:0006401)3.33948226
61response to parathyroid hormone (GO:0071107)3.33899813
62aldehyde catabolic process (GO:0046185)3.31925284
63semaphorin-plexin signaling pathway (GO:0071526)3.28701920
64apoptotic process involved in morphogenesis (GO:0060561)3.26820702
65cellular component biogenesis (GO:0044085)3.26692561
66positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.26661242
67pyrimidine nucleobase catabolic process (GO:0006208)3.26164530
68metallo-sulfur cluster assembly (GO:0031163)3.25036516
69iron-sulfur cluster assembly (GO:0016226)3.25036516
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.22963223
71spliceosomal snRNP assembly (GO:0000387)3.14432649
72positive regulation of histone deacetylation (GO:0031065)3.10267338
73dopamine receptor signaling pathway (GO:0007212)3.09632418
74UTP biosynthetic process (GO:0006228)3.09349594
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.08116723
76peptidyl-histidine modification (GO:0018202)3.06261923
77protein targeting to mitochondrion (GO:0006626)3.06195794
78modulation by virus of host morphology or physiology (GO:0019048)3.04610090
79respiratory chain complex IV assembly (GO:0008535)3.04272745
80regulation of water loss via skin (GO:0033561)3.03557956
81negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.03044580
82regulation of mitochondrial translation (GO:0070129)3.02313553
83endothelial cell chemotaxis (GO:0035767)2.99693552
84regulation of autophagic vacuole assembly (GO:2000785)2.97390722
85adherens junction assembly (GO:0034333)2.97253037
86mammary gland epithelial cell differentiation (GO:0060644)2.96711420
87establishment of protein localization to mitochondrion (GO:0072655)2.96336825
88modulation by virus of host process (GO:0019054)2.96171226
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96158192
90L-phenylalanine metabolic process (GO:0006558)2.95401241
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95401241
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.94620737
93establishment of protein localization to membrane (GO:0090150)2.94427054
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93347674
95transcription-coupled nucleotide-excision repair (GO:0006283)2.92016575
96protein targeting (GO:0006605)2.91930845
97ncRNA 3-end processing (GO:0043628)2.91199473
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89283680
99atrioventricular valve morphogenesis (GO:0003181)2.88577637
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88520696
101axon ensheathment in central nervous system (GO:0032291)2.87831169
102central nervous system myelination (GO:0022010)2.87831169
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84796753
104UTP metabolic process (GO:0046051)2.84315307
105cell-substrate adherens junction assembly (GO:0007045)2.81660638
106focal adhesion assembly (GO:0048041)2.81660638
107guanosine-containing compound biosynthetic process (GO:1901070)2.81575365
108viral mRNA export from host cell nucleus (GO:0046784)2.80661219
109telomere maintenance via semi-conservative replication (GO:0032201)2.79970995
110regulation of cellular amino acid metabolic process (GO:0006521)2.79879279
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79669074
112tooth mineralization (GO:0034505)2.79559164
113oxidative phosphorylation (GO:0006119)2.78338131
114glucose 6-phosphate metabolic process (GO:0051156)2.78178249
115negative regulation of catenin import into nucleus (GO:0035414)2.77438519
116camera-type eye morphogenesis (GO:0048593)2.76795118
117virion assembly (GO:0019068)2.76549050
118protein insertion into membrane (GO:0051205)2.75859696
119activation of MAPKKK activity (GO:0000185)2.75715617
120activation of Rac GTPase activity (GO:0032863)2.74369856
121regulation of fatty acid beta-oxidation (GO:0031998)2.73183555
122negative regulation of ligase activity (GO:0051352)2.72970886
123negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72970886
124vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72386291
125epithelial cell-cell adhesion (GO:0090136)2.72371883
126modulation by symbiont of host cellular process (GO:0044068)2.71556338
127response to UV-B (GO:0010224)2.70205275
128CTP biosynthetic process (GO:0006241)2.69875183
129CTP metabolic process (GO:0046036)2.69875183
130establishment of protein localization to organelle (GO:0072594)2.69733421
131apoptotic process involved in development (GO:1902742)2.69650410
132skeletal muscle organ development (GO:0060538)2.68583933
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66937504
134heme biosynthetic process (GO:0006783)2.66265835
135regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.66009519
136phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65806173
137intracellular estrogen receptor signaling pathway (GO:0030520)2.64219047
138protein localization to mitochondrion (GO:0070585)2.63495241
139DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63079271
140GDP-mannose metabolic process (GO:0019673)2.62830067
141spliceosomal complex assembly (GO:0000245)2.62780437
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62538148
143rRNA processing (GO:0006364)2.62187278
144negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61440392
1457-methylguanosine mRNA capping (GO:0006370)2.60529544
146deoxyribonucleotide catabolic process (GO:0009264)2.60339968
147amyloid precursor protein catabolic process (GO:0042987)2.59689092
148positive regulation of keratinocyte differentiation (GO:0045618)2.58888349
149DNA strand elongation involved in DNA replication (GO:0006271)2.58631936
150RNA capping (GO:0036260)2.58458721
1517-methylguanosine RNA capping (GO:0009452)2.58458721
152aerobic respiration (GO:0009060)2.56987798
153post-embryonic morphogenesis (GO:0009886)2.55474393
154protein targeting to plasma membrane (GO:0072661)2.55390096
155erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.55175908
156L-phenylalanine catabolic process (GO:0006559)2.55175908
157regulation of glycogen (starch) synthase activity (GO:2000465)2.55175625
158intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55028183
159signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55028183
160cellular response to virus (GO:0098586)2.53494351
161negative regulation of focal adhesion assembly (GO:0051895)2.53327434
162negative regulation of cell junction assembly (GO:1901889)2.53327434
163negative regulation of adherens junction organization (GO:1903392)2.53327434
164COPI coating of Golgi vesicle (GO:0048205)2.53057194
165Golgi transport vesicle coating (GO:0048200)2.53057194
166proline biosynthetic process (GO:0006561)2.52422979
167cytochrome complex assembly (GO:0017004)2.50917134
168viral protein processing (GO:0019082)2.50299901
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.49994809
170receptor recycling (GO:0001881)2.49297708
171regulation of vacuole organization (GO:0044088)2.48846841
172pattern specification involved in kidney development (GO:0061004)2.48358026
173positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48243911
174outflow tract septum morphogenesis (GO:0003148)2.47357297
175negative regulation of fatty acid transport (GO:2000192)2.46339445
176diaphragm development (GO:0060539)2.46163947
177body morphogenesis (GO:0010171)2.45899033
178regulation of defense response to virus by virus (GO:0050690)2.45439423
179positive regulation of T cell apoptotic process (GO:0070234)2.45298804
180regulation of histone deacetylation (GO:0031063)2.44923801
181cell migration in hindbrain (GO:0021535)2.44697426
182establishment of skin barrier (GO:0061436)2.42465813
183glucose catabolic process (GO:0006007)2.41720210
184uterus development (GO:0060065)2.39562089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.75793150
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.75201057
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.50850483
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48330573
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.45511263
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.38469332
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36580355
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27885377
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23906191
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.10860892
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.99514167
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93237411
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.87984098
14* XRN2_22483619_ChIP-Seq_HELA_Human2.85045869
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84604935
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75430173
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.73678162
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70321164
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62716636
20RACK7_27058665_Chip-Seq_MCF-7_Human2.60961656
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55900859
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49947993
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.47274698
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.45037319
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33730412
26E2F7_22180533_ChIP-Seq_HELA_Human2.33076794
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.32919463
28KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31170323
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27692219
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19680223
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.18128368
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07641746
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06686678
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.03386161
35KDM2B_26808549_Chip-Seq_DND41_Human2.02518598
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00867856
37ZNF263_19887448_ChIP-Seq_K562_Human2.00624454
38VDR_23849224_ChIP-Seq_CD4+_Human2.00211455
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99407094
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98750690
41KDM2B_26808549_Chip-Seq_K562_Human1.98116664
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96651097
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95401214
44TTF2_22483619_ChIP-Seq_HELA_Human1.95213148
45* P68_20966046_ChIP-Seq_HELA_Human1.94665555
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92633898
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92011349
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90532151
49MYC_22102868_ChIP-Seq_BL_Human1.89196419
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.88150433
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.85457247
52* DCP1A_22483619_ChIP-Seq_HELA_Human1.85066842
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81913292
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81721216
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81593812
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79525803
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79146823
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77177652
59FOXP3_21729870_ChIP-Seq_TREG_Human1.76748387
60TCF7_22412390_ChIP-Seq_EML_Mouse1.73117597
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72231623
62* SMC4_20622854_ChIP-Seq_HELA_Human1.70300104
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.70264892
64GABP_19822575_ChIP-Seq_HepG2_Human1.70085199
65CTCF_27219007_Chip-Seq_Bcells_Human1.68305825
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68168986
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.63305434
68CREB1_26743006_Chip-Seq_LNCaP_Human1.62878253
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61591757
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60574872
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57829165
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57341557
73VDR_21846776_ChIP-Seq_THP-1_Human1.55338935
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.53380423
75CTCF_18555785_ChIP-Seq_MESCs_Mouse1.52807715
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49873630
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49759451
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45186801
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.44608825
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44538948
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.43997745
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.43681989
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42243053
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41588318
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41431798
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39224404
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39193487
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37497666
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.34873677
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34635632
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33717024
92CIITA_25753668_ChIP-Seq_RAJI_Human1.33434606
93MYC_18940864_ChIP-ChIP_HL60_Human1.32673753
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32411916
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31948839
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.31281758
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30786247
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.30663025
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30586084
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.28732209
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.27744255
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27625485
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27288613
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23359424
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23153119
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22310726
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22051764
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19896613
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19278227
110TP63_22573176_ChIP-Seq_HFKS_Human1.19140591
111SA1_27219007_Chip-Seq_Bcells_Human1.18802423
112MAF_26560356_Chip-Seq_TH2_Human1.18108544
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17988374
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.16803820
115ATF3_27146783_Chip-Seq_COLON_Human1.16305478
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16302877
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16258319
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15858036
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13768962
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13658365
121* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13281134
122* TP53_22127205_ChIP-Seq_IMR90_Human1.12262214
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12054339
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.11061906
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11054439
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11029029
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10864499
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10558300
129* BCL6_27268052_Chip-Seq_Bcells_Human1.09603201
130E2F1_20622854_ChIP-Seq_HELA_Human1.08096341
131P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07121887
132ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07035666
133STAT1_20625510_ChIP-Seq_HELA_Human1.06629503
134EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06350624
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06210529
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05984038
137ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04233158
138TP63_19390658_ChIP-ChIP_HaCaT_Human1.03229009
139PHF8_20622854_ChIP-Seq_HELA_Human1.03162960
140ELK1_19687146_ChIP-ChIP_HELA_Human1.03059586
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02933869
142RARB_24833708_ChIP-Seq_LIVER_Mouse1.02836869
143HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02640811
144P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02188878
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01664324
146TET1_21490601_ChIP-Seq_MESCs_Mouse1.01339446
147* CTCF_20526341_ChIP-Seq_ESCs_Human1.01231170
148CTCF_21964334_Chip-Seq_Bcells_Human1.01028714
149* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00759898
150* RARA_24833708_ChIP-Seq_LIVER_Mouse1.00220920
151FOXP1_21924763_ChIP-Seq_HESCs_Human0.99727402
152CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99449211
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99276320
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98989442
155* CTCF_26484167_Chip-Seq_Bcells_Mouse0.98932072
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98268635
157NCOR1_26117541_ChIP-Seq_K562_Human0.98255001
158STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98242442
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97971009
160E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97645464
161SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96962491
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96685298
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96532050
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95669678
165IRF8_22096565_ChIP-ChIP_GC-B_Human0.94567466
166UTX_26944678_Chip-Seq_JUKART_Human0.94398725
167TRIM28_21343339_ChIP-Seq_HEK293_Human0.94369224
168NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92978352
169KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92200798
170LXR_22292898_ChIP-Seq_THP-1_Human0.90306900
171NANOG_20526341_ChIP-Seq_ESCs_Human0.87018028
172* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86450146
173CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85596159
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82944560
175* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82409098
176ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82127455
177VDR_24763502_ChIP-Seq_THP-1_Human0.81700490
178BCOR_27268052_Chip-Seq_Bcells_Human0.81681231
179SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80981232
180IRF1_19129219_ChIP-ChIP_H3396_Human0.80183975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.23551375
2MP0003705_abnormal_hypodermis_morpholog4.58686787
3MP0003011_delayed_dark_adaptation4.51663483
4MP0004858_abnormal_nervous_system3.56005817
5MP0003123_paternal_imprinting3.50010330
6MP0002796_impaired_skin_barrier2.90493556
7MP0000678_abnormal_parathyroid_gland2.83416466
8MP0006292_abnormal_olfactory_placode2.78027148
9MP0010234_abnormal_vibrissa_follicle2.74275731
10MP0000685_abnormal_immune_system2.19633319
11MP0003186_abnormal_redox_activity2.19565278
12MP0004185_abnormal_adipocyte_glucose2.19341308
13MP0005501_abnormal_skin_physiology2.18983245
14MP0003693_abnormal_embryo_hatching2.14037556
15MP0002139_abnormal_hepatobiliary_system2.10904885
16MP0008789_abnormal_olfactory_epithelium2.10760420
17MP0004381_abnormal_hair_follicle2.04013883
18MP0005360_urolithiasis2.02786520
19MP0001529_abnormal_vocalization2.00449542
20MP0005075_abnormal_melanosome_morpholog1.97465258
21MP0001835_abnormal_antigen_presentation1.96652556
22MP0003806_abnormal_nucleotide_metabolis1.94166381
23MP0000049_abnormal_middle_ear1.93851423
24MP0003879_abnormal_hair_cell1.92372515
25MP0005058_abnormal_lysosome_morphology1.87625975
26MP0002098_abnormal_vibrissa_morphology1.80618654
27MP0003942_abnormal_urinary_system1.80104193
28MP0005076_abnormal_cell_differentiation1.79396526
29MP0008932_abnormal_embryonic_tissue1.75722669
30MP0001348_abnormal_lacrimal_gland1.72796999
31MP0002138_abnormal_hepatobiliary_system1.72291615
32MP0001849_ear_inflammation1.71625566
33MP0000534_abnormal_ureter_morphology1.70647647
34MP0004264_abnormal_extraembryonic_tissu1.70393009
35MP0001905_abnormal_dopamine_level1.64135907
36MP0002163_abnormal_gland_morphology1.63317289
37MP0005085_abnormal_gallbladder_physiolo1.61473865
38MP0000566_synostosis1.58513564
39MP0005666_abnormal_adipose_tissue1.55805835
40MP0003938_abnormal_ear_development1.55535588
41MP0002938_white_spotting1.53562221
42MP0002132_abnormal_respiratory_system1.53164636
43MP0000579_abnormal_nail_morphology1.52715219
44MP0003315_abnormal_perineum_morphology1.52243112
45MP0009785_altered_susceptibility_to1.50508592
46MP0002653_abnormal_ependyma_morphology1.49593847
47MP0005084_abnormal_gallbladder_morpholo1.49216842
48MP0003453_abnormal_keratinocyte_physiol1.49061535
49MP0006036_abnormal_mitochondrial_physio1.47298171
50MP0004133_heterotaxia1.46456197
51MP0003763_abnormal_thymus_physiology1.45885592
52MP0006276_abnormal_autonomic_nervous1.45050879
53MP0002148_abnormal_hypersensitivity_rea1.44936702
54MP0005671_abnormal_response_to1.43001329
55MP0004142_abnormal_muscle_tone1.41942360
56MP0005375_adipose_tissue_phenotype1.39447058
57MP0002249_abnormal_larynx_morphology1.38780760
58MP0003136_yellow_coat_color1.37831587
59MP0005365_abnormal_bile_salt1.35638185
60MP0005257_abnormal_intraocular_pressure1.34339208
61MP0005377_hearing/vestibular/ear_phenot1.34059142
62MP0003878_abnormal_ear_physiology1.34059142
63MP0009053_abnormal_anal_canal1.32036592
64MP0010030_abnormal_orbit_morphology1.31658592
65MP0009840_abnormal_foam_cell1.30256199
66MP0000613_abnormal_salivary_gland1.30247418
67MP0001346_abnormal_lacrimal_gland1.29981660
68MP0002751_abnormal_autonomic_nervous1.29262181
69MP0005670_abnormal_white_adipose1.28500997
70MP0002089_abnormal_postnatal_growth/wei1.28132119
71MP0000750_abnormal_muscle_regeneration1.28128735
72MP0008875_abnormal_xenobiotic_pharmacok1.27800010
73MP0009333_abnormal_splenocyte_physiolog1.26290621
74MP0000462_abnormal_digestive_system1.25024233
75MP0005387_immune_system_phenotype1.24181284
76MP0001790_abnormal_immune_system1.24181284
77MP0005025_abnormal_response_to1.22996800
78MP0001800_abnormal_humoral_immune1.21057598
79MP0000467_abnormal_esophagus_morphology1.19630586
80MP0005503_abnormal_tendon_morphology1.19038673
81MP0005394_taste/olfaction_phenotype1.18741650
82MP0005499_abnormal_olfactory_system1.18741650
83MP0009384_cardiac_valve_regurgitation1.17558058
84MP0002102_abnormal_ear_morphology1.16132944
85MP0004233_abnormal_muscle_weight1.14847038
86MP0000537_abnormal_urethra_morphology1.14336979
87MP0001663_abnormal_digestive_system1.13388731
88MP0003566_abnormal_cell_adhesion1.11612684
89MP0005623_abnormal_meninges_morphology1.11346146
90MP0006035_abnormal_mitochondrial_morpho1.10854571
91MP0000003_abnormal_adipose_tissue1.10525099
92MP0003077_abnormal_cell_cycle1.09433211
93MP0001873_stomach_inflammation1.09094316
94MP0005174_abnormal_tail_pigmentation1.07896017
95MP0005381_digestive/alimentary_phenotyp1.07550545
96MP0003787_abnormal_imprinting1.07301750
97MP0005083_abnormal_biliary_tract1.07197197
98MP0008260_abnormal_autophagy1.06944868
99MP0008058_abnormal_DNA_repair1.06874184
100MP0005409_darkened_coat_color1.06544107
101MP0004510_myositis1.04941017
102MP0002723_abnormal_immune_serum1.04649128
103MP0003191_abnormal_cellular_cholesterol1.04641868
104MP0009278_abnormal_bone_marrow1.04579279
105MP0002420_abnormal_adaptive_immunity1.02503029
106MP0005332_abnormal_amino_acid1.02171226
107MP0002282_abnormal_trachea_morphology1.02150883
108MP0000026_abnormal_inner_ear1.02131005
109MP0000716_abnormal_immune_system1.01937317
110MP0005000_abnormal_immune_tolerance1.01763356
111MP0001819_abnormal_immune_cell1.01185354
112MP0002398_abnormal_bone_marrow0.98942284
113MP0004130_abnormal_muscle_cell0.98608216
114MP0000762_abnormal_tongue_morphology0.97249302
115MP0002277_abnormal_respiratory_mucosa0.97048439
116MP0003279_aneurysm0.96471861
117MP0003303_peritoneal_inflammation0.95440817
118MP0002452_abnormal_antigen_presenting0.95354919
119MP0003329_amyloid_beta_deposits0.95259068
120MP0009780_abnormal_chondrocyte_physiolo0.94900292
121MP0005275_abnormal_skin_tensile0.94779454
122MP0000377_abnormal_hair_follicle0.94585722
123MP0002429_abnormal_blood_cell0.94263774
124MP0001664_abnormal_digestion0.94156676
125MP0008438_abnormal_cutaneous_collagen0.93714899
126MP0000733_abnormal_muscle_development0.93410137
127MP0005451_abnormal_body_composition0.93133858
128MP0010771_integument_phenotype0.91171394
129MP0004957_abnormal_blastocyst_morpholog0.90742917
130MP0002116_abnormal_craniofacial_bone0.90088902
131MP0004859_abnormal_synaptic_plasticity0.88780599
132MP0001764_abnormal_homeostasis0.88093050
133MP0002638_abnormal_pupillary_reflex0.86327432
134MP0005508_abnormal_skeleton_morphology0.85715456
135MP0002060_abnormal_skin_morphology0.85656401
136MP0002932_abnormal_joint_morphology0.85317147
137MP0001958_emphysema0.85275120
138MP0005379_endocrine/exocrine_gland_phen0.85239570
139MP0001216_abnormal_epidermal_layer0.84587059
140MP0001485_abnormal_pinna_reflex0.83613796
141MP0000689_abnormal_spleen_morphology0.83174950
142MP0000470_abnormal_stomach_morphology0.82607174
143MP0009931_abnormal_skin_appearance0.82075929
144MP0000778_abnormal_nervous_system0.81356925
145MP0002722_abnormal_immune_system0.80605922
146MP0005584_abnormal_enzyme/coenzyme_acti0.80316420
147MP0005636_abnormal_mineral_homeostasis0.79976973
148MP0002822_catalepsy0.79922572
149MP0004019_abnormal_vitamin_homeostasis0.78876614
150MP0000920_abnormal_myelination0.78116124
151MP0000759_abnormal_skeletal_muscle0.77845758
152MP0009697_abnormal_copulation0.77721410
153MP0003718_maternal_effect0.76968433
154MP0002396_abnormal_hematopoietic_system0.76626337
155MP0004947_skin_inflammation0.76588828
156MP0003385_abnormal_body_wall0.76019681
157MP0001984_abnormal_olfaction0.75941403
158MP0008469_abnormal_protein_level0.74573035
159MP0001881_abnormal_mammary_gland0.74309945
160MP0000681_abnormal_thyroid_gland0.74042657
161MP0004742_abnormal_vestibular_system0.73571921
162MP0000703_abnormal_thymus_morphology0.73550086
163MP0002752_abnormal_somatic_nervous0.72354606
164MP0002405_respiratory_system_inflammati0.72271209
165MP0009250_abnormal_appendicular_skeleto0.72195937
166MP0000858_altered_metastatic_potential0.70832635
167MP0000538_abnormal_urinary_bladder0.69392513
168MP0002877_abnormal_melanocyte_morpholog0.69026670
169MP0003866_abnormal_defecation0.68935579
170MP0002108_abnormal_muscle_morphology0.68464309
171MP0003122_maternal_imprinting0.67726938
172MP0001765_abnormal_ion_homeostasis0.67025775
173MP0000751_myopathy0.66972760
174MP0003183_abnormal_peptide_metabolism0.66626550
175MP0000477_abnormal_intestine_morphology0.62655797
176MP0001502_abnormal_circadian_rhythm0.62325012
177MP0004782_abnormal_surfactant_physiolog0.61437265
178MP0003638_abnormal_response/metabolism_0.60886211

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sacrum (HP:0008517)5.25256848
2Hepatocellular necrosis (HP:0001404)4.89264115
3Acute necrotizing encephalopathy (HP:0006965)4.74413406
4Mitochondrial inheritance (HP:0001427)4.74056507
5Reticulocytopenia (HP:0001896)4.69521786
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.56993992
7Decreased activity of mitochondrial respiratory chain (HP:0008972)4.56993992
8Abnormal mitochondria in muscle tissue (HP:0008316)4.34277701
9Hepatic necrosis (HP:0002605)4.33870086
10Acute encephalopathy (HP:0006846)4.07942439
11Abnormality of cells of the erythroid lineage (HP:0012130)4.03324511
12Macrocytic anemia (HP:0001972)3.98423386
13Renal Fanconi syndrome (HP:0001994)3.98192973
14Increased CSF lactate (HP:0002490)3.93044115
15Hyperthyroidism (HP:0000836)3.92625246
16Increased hepatocellular lipid droplets (HP:0006565)3.91618764
17Progressive macrocephaly (HP:0004481)3.84528318
18Abnormal number of erythroid precursors (HP:0012131)3.75455282
193-Methylglutaconic aciduria (HP:0003535)3.65366411
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.65122320
21Hyperacusis (HP:0010780)3.64273072
22Lipid accumulation in hepatocytes (HP:0006561)3.61429179
23Obstructive sleep apnea (HP:0002870)3.55941947
24Exertional dyspnea (HP:0002875)3.50044579
25Abnormal hemoglobin (HP:0011902)3.49793180
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46635394
27Distal lower limb muscle weakness (HP:0009053)3.45775700
28Increased intramyocellular lipid droplets (HP:0012240)3.45523138
29Hyperparathyroidism (HP:0000843)3.43647691
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42281409
31Cerebral edema (HP:0002181)3.25482707
32Pallor (HP:0000980)3.21385679
33Increased serum lactate (HP:0002151)3.07659299
34Increased muscle lipid content (HP:0009058)3.05477237
35Achilles tendon contracture (HP:0001771)3.03643564
36Thin bony cortex (HP:0002753)3.03224929
37Microretrognathia (HP:0000308)2.86667290
38Respiratory failure (HP:0002878)2.85399953
39Long palpebral fissure (HP:0000637)2.85125618
40Leukodystrophy (HP:0002415)2.84043113
41Lactic acidosis (HP:0003128)2.81591305
42Abnormality of the aortic arch (HP:0012303)2.78387761
43Hypercortisolism (HP:0001578)2.76994951
44J-shaped sella turcica (HP:0002680)2.71374028
45Abnormality of the Achilles tendon (HP:0005109)2.70264945
46Bulbar palsy (HP:0001283)2.62344079
47Atelectasis (HP:0100750)2.59997034
48Myopathic facies (HP:0002058)2.58808994
49Protrusio acetabuli (HP:0003179)2.57985745
50Growth hormone excess (HP:0000845)2.56604768
51Mitral regurgitation (HP:0001653)2.52996909
52Large eyes (HP:0001090)2.52926829
53Elevated erythrocyte sedimentation rate (HP:0003565)2.52449167
54Optic disc pallor (HP:0000543)2.50441932
55Mildly elevated creatine phosphokinase (HP:0008180)2.48572722
56Disproportionate tall stature (HP:0001519)2.48568276
57Septate vagina (HP:0001153)2.47129485
58Abnormality of glycolysis (HP:0004366)2.45936864
59Increased serum pyruvate (HP:0003542)2.45936864
60Stridor (HP:0010307)2.45121382
61Cervical subluxation (HP:0003308)2.43883878
62Exercise intolerance (HP:0003546)2.41216208
63Abnormality of the phalanges of the hallux (HP:0010057)2.41026699
64Distal upper limb amyotrophy (HP:0007149)2.39211000
65Upper limb amyotrophy (HP:0009129)2.39211000
66Shallow orbits (HP:0000586)2.35235165
67Flat acetabular roof (HP:0003180)2.32727136
68Delayed CNS myelination (HP:0002188)2.31317107
69Cerebral hypomyelination (HP:0006808)2.31082570
70Congenital glaucoma (HP:0001087)2.30478770
71Broad face (HP:0000283)2.30229617
72Concave nail (HP:0001598)2.27866492
73Abnormality of renal resorption (HP:0011038)2.24798572
74Truncus arteriosus (HP:0001660)2.23936789
75Easy fatigability (HP:0003388)2.23651243
76Fragile skin (HP:0001030)2.23441228
77Vertebral compression fractures (HP:0002953)2.20709506
78Abnormality of the thoracic spine (HP:0100711)2.19773257
79Hyperphosphaturia (HP:0003109)2.19670556
80Patellar dislocation (HP:0002999)2.18841614
81Axonal loss (HP:0003447)2.17547205
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.16276041
83Parakeratosis (HP:0001036)2.15944589
84Thrombocytosis (HP:0001894)2.15584152
85Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.13141621
86Abdominal distention (HP:0003270)2.12493882
87CNS demyelination (HP:0007305)2.12322190
88Lethargy (HP:0001254)2.11848191
89Abnormality of the distal phalanges of the toes (HP:0010182)2.11760953
90Enlarged penis (HP:0000040)2.11299703
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11239948
92Type I transferrin isoform profile (HP:0003642)2.11198310
93Glycosuria (HP:0003076)2.10745334
94Abnormality of urine glucose concentration (HP:0011016)2.10745334
95Nasal polyposis (HP:0100582)2.10059193
96Short femoral neck (HP:0100864)2.09325527
97Deep palmar crease (HP:0006191)2.09065018
98Distal lower limb amyotrophy (HP:0008944)2.08565932
99Colon cancer (HP:0003003)2.08473767
100Spinal cord compression (HP:0002176)2.07973118
101Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06655912
102Oral leukoplakia (HP:0002745)2.05361329
103Hypercalcemia (HP:0003072)2.04480700
104Myokymia (HP:0002411)2.03325593
105Asplenia (HP:0001746)2.02323261
106Respiratory difficulties (HP:0002880)2.02241131
107Abnormality of the heme biosynthetic pathway (HP:0010472)2.01832284
108Aplasia/hypoplasia of the uterus (HP:0008684)2.01702044
109Microcytic anemia (HP:0001935)2.01652065
110Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00350303
111Abnormality of the nasal mucosa (HP:0000433)1.99297669
112Macroorchidism (HP:0000053)1.99056059
113Aplastic anemia (HP:0001915)1.97840373
114Lymphangioma (HP:0100764)1.97088115
115Seborrheic dermatitis (HP:0001051)1.96916417
116Hypochromic anemia (HP:0001931)1.96900704
117Ulnar bowing (HP:0003031)1.96349312
118Hypoparathyroidism (HP:0000829)1.95618401
119Precocious puberty (HP:0000826)1.94865332
120Cerebral palsy (HP:0100021)1.93747193
121Hypobetalipoproteinemia (HP:0003563)1.93165160
122Down-sloping shoulders (HP:0200021)1.92958311
123Spinal rigidity (HP:0003306)1.92281948
124Genu recurvatum (HP:0002816)1.92104556
125Long toe (HP:0010511)1.91698243
126Germ cell neoplasia (HP:0100728)1.91633079
127Optic nerve coloboma (HP:0000588)1.90498204
128Increased variability in muscle fiber diameter (HP:0003557)1.89289830
129Asymmetry of the thorax (HP:0001555)1.89178670
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.89144148
131Insomnia (HP:0100785)1.88946680
132Flattened epiphyses (HP:0003071)1.87821238
133Acanthosis nigricans (HP:0000956)1.87663190
134Increased IgM level (HP:0003496)1.87618425
135Hyperphosphatemia (HP:0002905)1.86201316
136Pointed chin (HP:0000307)1.84341328
137Testicular atrophy (HP:0000029)1.83211342
138Short nail (HP:0001799)1.81133023
139Abnormal urine phosphate concentration (HP:0012599)1.79499132
140Emotional lability (HP:0000712)1.78611714
141Myelomeningocele (HP:0002475)1.78411958
142Annular pancreas (HP:0001734)1.77919174
143Prolonged partial thromboplastin time (HP:0003645)1.77688960
144Reticulocytosis (HP:0001923)1.77070538
145Abnormality of pyrimidine metabolism (HP:0004353)1.76163133
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75971376
147Bowed forearm bones (HP:0003956)1.75873895
148Bowing of the arm (HP:0006488)1.75873895
149Anomalous pulmonary venous return (HP:0010772)1.75520790
150Premature rupture of membranes (HP:0001788)1.75514850
151Reduced antithrombin III activity (HP:0001976)1.74969723
152Spastic paraparesis (HP:0002313)1.74346639
153Chronic otitis media (HP:0000389)1.74134393
154Neoplasm of head and neck (HP:0012288)1.73994588
155Esophageal neoplasm (HP:0100751)1.73994588
156Centrally nucleated skeletal muscle fibers (HP:0003687)1.73933463
157Abnormality of the tricuspid valve (HP:0001702)1.73835484
158Triphalangeal thumb (HP:0001199)1.73632943
159Increased connective tissue (HP:0009025)1.73046651
160Abnormality of reticulocytes (HP:0004312)1.72912552
161Elfin facies (HP:0004428)1.72192517
162Cerebral aneurysm (HP:0004944)1.71559449
163Gastrointestinal stroma tumor (HP:0100723)1.71307548
164Thoracic kyphosis (HP:0002942)1.70891426
165Cleft eyelid (HP:0000625)1.70082376
166Dry hair (HP:0011359)1.70072048
167Foot dorsiflexor weakness (HP:0009027)1.69413695
168Bladder diverticulum (HP:0000015)1.69148311
169Hypertensive crisis (HP:0100735)1.68611724
170Hand muscle atrophy (HP:0009130)1.68292460
171Depressed nasal ridge (HP:0000457)1.67243695
172Elbow flexion contracture (HP:0002987)1.66892046
173Ulnar deviation of the wrist (HP:0003049)1.66747970
174Renal dysplasia (HP:0000110)1.66410920
175Broad distal phalanx of finger (HP:0009836)1.66377165
176Partial duplication of thumb phalanx (HP:0009944)1.65774887
177Partial duplication of the phalanx of hand (HP:0009999)1.63572430
178Agammaglobulinemia (HP:0004432)1.63277546
179Purpura (HP:0000979)1.62674077
180Prolonged neonatal jaundice (HP:0006579)1.62477953
181Abnormality of the pulmonary veins (HP:0011718)1.62200852
182Pancytopenia (HP:0001876)1.59990504
183Congenital ichthyosiform erythroderma (HP:0007431)1.59069591
184Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.58525859
185Abnormal sex determination (HP:0012244)1.58021819
186Sex reversal (HP:0012245)1.58021819
187Deep venous thrombosis (HP:0002625)1.56742778
188Renal tubular dysfunction (HP:0000124)1.55515968
189Gastrointestinal infarctions (HP:0005244)1.55115844
190Opisthotonus (HP:0002179)1.53550154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.54536128
2TLK14.85162197
3STK163.83983085
4SIK13.77226161
5NME23.53403620
6TESK23.16725665
7CDK192.94880500
8SMG12.94753360
9EPHA22.90361981
10ERN12.69398547
11PIM22.52490269
12BUB12.47428795
13LIMK12.39344634
14ARAF2.26395745
15BCKDK2.25312284
16PKN22.21341419
17IRAK12.14288465
18DYRK22.06809609
19BRAF1.94740805
20DYRK31.90969022
21IRAK41.84801090
22RIPK11.83520368
23TAOK11.82475830
24MAPKAPK31.73876863
25EEF2K1.72807374
26BLK1.72657455
27BCR1.71494775
28MAP4K11.66864584
29IRAK21.65378838
30PRKD31.64624839
31STK391.62650011
32SRPK11.55189498
33ACVR1B1.55100107
34MARK21.54857089
35EIF2AK11.51776244
36RPS6KB21.49485929
37NME11.47976174
38MST41.45312941
39MUSK1.41599020
40VRK11.40889814
41EPHB21.39683231
42TAOK21.36233779
43RPS6KA21.35774435
44PTK61.30850763
45IRAK31.29705869
46TESK11.26984003
47CSNK1G31.26062380
48MAP2K21.24872402
49KIT1.21945478
50MAP3K111.21457480
51PBK1.20372534
52ICK1.20348016
53RPS6KA51.18997123
54TTN1.18043053
55MAP3K91.11246608
56UHMK11.09372798
57SIK31.09349293
58BTK1.06543308
59KDR1.05925414
60LRRK21.04961280
61DAPK31.03376581
62PDPK11.02290045
63CDC42BPA1.01519014
64MTOR0.97235458
65PTK20.95836264
66HIPK20.95806553
67DYRK1B0.95286666
68CSF1R0.94205924
69CASK0.93345957
70MKNK10.91787272
71TBK10.91324857
72CAMKK10.89639469
73DMPK0.89252541
74TYRO30.87427136
75BMPR1B0.85185912
76TNIK0.85138263
77ADRBK20.85019312
78EPHB10.83705400
79LMTK20.83595244
80TNK20.82434619
81SIK20.81767039
82CSNK1G10.81366419
83PKN10.80756543
84ILK0.80221903
85ABL20.79704534
86CDK120.79429430
87OXSR10.78830157
88CLK10.78043536
89MAP3K100.77550892
90MAP3K10.76144868
91IKBKE0.74176869
92MAP3K30.72215056
93CSNK1A1L0.69367562
94PRKCI0.68406715
95TGFBR10.67765185
96NTRK10.66788043
97MAP2K30.65360944
98GRK60.65087295
99WEE10.63683982
100IKBKB0.63319080
101AURKA0.62256852
102PRKG20.62194149
103VRK20.60111280
104MAPK150.59567795
105MAPK130.58597162
106PAK40.57664285
107KSR20.56550426
108NEK90.55913128
109CDK70.55823703
110PRKD10.55153125
111WNK40.54785921
112PAK10.51870571
113MKNK20.51670594
114SYK0.51408320
115ROCK20.51000521
116CAMK1D0.50203765
117MAP2K60.49719311
118CAMK2G0.48743482
119MYLK0.48403368
120RPS6KA40.48038513
121BMX0.47689353
122FLT30.47177899
123LYN0.47068211
124PRKCQ0.46071632
125PDK10.45856898
126MAP2K10.45660206
127CDK80.44718406
128MAP3K120.43260216
129DDR20.43221561
130CSNK2A10.43073674
131PRKCH0.42889958
132MAPK120.42584482
133PRKD20.42283239
134YES10.42202484
135STK380.41483206
136PDGFRA0.40801830
137MAPKAPK50.40646075
138MST1R0.38186606
139RPS6KA10.38172540
140AKT20.37584966
141MAPKAPK20.37385218
142NLK0.37064173
143RPS6KC10.36996828
144RPS6KL10.36996828
145RIPK40.36059402
146MAP2K70.35907437
147CHUK0.35527727
148PRKCZ0.34746537
149PIK3CA0.34497094
150PRPF4B0.34426342
151FGFR40.34412876
152MAP3K80.34196333
153PIM10.33899478
154RPS6KA60.33231824
155AURKB0.31870064
156LCK0.31606957
157TXK0.31488452
158MAPK40.31445175
159CDK11A0.31074846

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.34137655
2Oxidative phosphorylation_Homo sapiens_hsa001903.43571726
3Parkinsons disease_Homo sapiens_hsa050123.17108618
4Proteasome_Homo sapiens_hsa030503.14638362
5RNA polymerase_Homo sapiens_hsa030202.70244019
6DNA replication_Homo sapiens_hsa030302.64060539
7Sulfur relay system_Homo sapiens_hsa041222.56855657
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39732774
9Mismatch repair_Homo sapiens_hsa034302.23449757
10Spliceosome_Homo sapiens_hsa030402.20102934
11Huntingtons disease_Homo sapiens_hsa050162.17036065
12VEGF signaling pathway_Homo sapiens_hsa043702.14371956
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13606589
14Alzheimers disease_Homo sapiens_hsa050102.07653685
15Pyrimidine metabolism_Homo sapiens_hsa002402.06062734
16Acute myeloid leukemia_Homo sapiens_hsa052212.02328873
17Protein export_Homo sapiens_hsa030601.98524302
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97847720
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89183278
20Folate biosynthesis_Homo sapiens_hsa007901.88943575
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81720649
22Nucleotide excision repair_Homo sapiens_hsa034201.77034386
23Endometrial cancer_Homo sapiens_hsa052131.75848622
24Homologous recombination_Homo sapiens_hsa034401.74581046
25Bladder cancer_Homo sapiens_hsa052191.74066458
26Base excision repair_Homo sapiens_hsa034101.72984947
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66530267
28Chronic myeloid leukemia_Homo sapiens_hsa052201.62815245
29Non-small cell lung cancer_Homo sapiens_hsa052231.60638575
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54633087
31Vibrio cholerae infection_Homo sapiens_hsa051101.54231271
32Thyroid cancer_Homo sapiens_hsa052161.53835573
33Fatty acid elongation_Homo sapiens_hsa000621.51967286
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45329034
35Prion diseases_Homo sapiens_hsa050201.43755674
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36705537
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.36086590
38Insulin signaling pathway_Homo sapiens_hsa049101.36061261
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35296783
40AMPK signaling pathway_Homo sapiens_hsa041521.31764077
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31042649
42Fructose and mannose metabolism_Homo sapiens_hsa000511.30623287
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.28857147
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27759677
45ErbB signaling pathway_Homo sapiens_hsa040121.26123505
46Other glycan degradation_Homo sapiens_hsa005111.24890306
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.22580625
48Galactose metabolism_Homo sapiens_hsa000521.22204969
49Primary immunodeficiency_Homo sapiens_hsa053401.20679938
50Renal cell carcinoma_Homo sapiens_hsa052111.18397337
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18169834
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18014853
53Glioma_Homo sapiens_hsa052141.16595274
54Endocytosis_Homo sapiens_hsa041441.14510434
55Axon guidance_Homo sapiens_hsa043601.14504649
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14057789
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.12075719
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11066467
59Glutathione metabolism_Homo sapiens_hsa004801.10485052
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10377878
61mTOR signaling pathway_Homo sapiens_hsa041501.09816288
62Peroxisome_Homo sapiens_hsa041461.08658350
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08634075
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07857675
65One carbon pool by folate_Homo sapiens_hsa006701.07642303
66Allograft rejection_Homo sapiens_hsa053301.06513111
67Steroid biosynthesis_Homo sapiens_hsa001001.05842947
68Synaptic vesicle cycle_Homo sapiens_hsa047211.04414291
69Pancreatic cancer_Homo sapiens_hsa052121.04329143
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04215689
71B cell receptor signaling pathway_Homo sapiens_hsa046621.03834717
72Phospholipase D signaling pathway_Homo sapiens_hsa040721.03707142
73Choline metabolism in cancer_Homo sapiens_hsa052311.02726206
74Hepatitis C_Homo sapiens_hsa051601.02500200
75Melanogenesis_Homo sapiens_hsa049161.02445078
76Systemic lupus erythematosus_Homo sapiens_hsa053221.01119403
77Dilated cardiomyopathy_Homo sapiens_hsa054141.00715589
78Chemical carcinogenesis_Homo sapiens_hsa052041.00289323
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00225943
80Histidine metabolism_Homo sapiens_hsa003400.98273870
81GnRH signaling pathway_Homo sapiens_hsa049120.97180227
82Tight junction_Homo sapiens_hsa045300.97178055
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93720979
84Estrogen signaling pathway_Homo sapiens_hsa049150.93247953
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.91933496
86Arginine and proline metabolism_Homo sapiens_hsa003300.91226068
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.90880195
88Tryptophan metabolism_Homo sapiens_hsa003800.89087825
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88891757
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.88213953
91Basal transcription factors_Homo sapiens_hsa030220.88176588
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86551224
93Insulin resistance_Homo sapiens_hsa049310.86424526
94Butanoate metabolism_Homo sapiens_hsa006500.85531639
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81820138
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81467404
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.81168283
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80690930
99Purine metabolism_Homo sapiens_hsa002300.80548261
100Melanoma_Homo sapiens_hsa052180.80324044
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.79650397
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79519240
103Cardiac muscle contraction_Homo sapiens_hsa042600.79039159
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78283674
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76490603
106Autoimmune thyroid disease_Homo sapiens_hsa053200.75323036
107Focal adhesion_Homo sapiens_hsa045100.74898532
108Retinol metabolism_Homo sapiens_hsa008300.74541006
109Amoebiasis_Homo sapiens_hsa051460.74188513
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.73866326
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73104177
112Hedgehog signaling pathway_Homo sapiens_hsa043400.73006078
113Gap junction_Homo sapiens_hsa045400.72671446
114beta-Alanine metabolism_Homo sapiens_hsa004100.72299314
115Tyrosine metabolism_Homo sapiens_hsa003500.71077846
116Lysosome_Homo sapiens_hsa041420.70787441
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70379675
118Metabolic pathways_Homo sapiens_hsa011000.69083080
119Hippo signaling pathway_Homo sapiens_hsa043900.67108340
120RNA degradation_Homo sapiens_hsa030180.65953676
121Proteoglycans in cancer_Homo sapiens_hsa052050.65750006
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65490193
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64580079
124Prostate cancer_Homo sapiens_hsa052150.64468502
125Rap1 signaling pathway_Homo sapiens_hsa040150.63438143
126Colorectal cancer_Homo sapiens_hsa052100.62958088
127Cocaine addiction_Homo sapiens_hsa050300.62945747
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.62722199
129Pentose phosphate pathway_Homo sapiens_hsa000300.61960916
130Glucagon signaling pathway_Homo sapiens_hsa049220.61746176
131Cholinergic synapse_Homo sapiens_hsa047250.61293201
132Fatty acid degradation_Homo sapiens_hsa000710.60857830
133Prolactin signaling pathway_Homo sapiens_hsa049170.60234285
134Long-term potentiation_Homo sapiens_hsa047200.60016735
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59325511
136Fanconi anemia pathway_Homo sapiens_hsa034600.59003894
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58182636
138Pyruvate metabolism_Homo sapiens_hsa006200.56713717
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56587920
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55969439
141RNA transport_Homo sapiens_hsa030130.53345742
142MAPK signaling pathway_Homo sapiens_hsa040100.53156429
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52075859
144Graft-versus-host disease_Homo sapiens_hsa053320.50937326
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50366847
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50158424
147Fat digestion and absorption_Homo sapiens_hsa049750.49656863
148Epstein-Barr virus infection_Homo sapiens_hsa051690.48827378
149Salmonella infection_Homo sapiens_hsa051320.48471678
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46728632
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46644257
152Apoptosis_Homo sapiens_hsa042100.45877306
153Gastric acid secretion_Homo sapiens_hsa049710.45481531
154Chemokine signaling pathway_Homo sapiens_hsa040620.45283353
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.45010574
156Arachidonic acid metabolism_Homo sapiens_hsa005900.44142994
157Phenylalanine metabolism_Homo sapiens_hsa003600.43914743
158Bile secretion_Homo sapiens_hsa049760.43867737
159Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42433998
160Propanoate metabolism_Homo sapiens_hsa006400.41647157
161Inositol phosphate metabolism_Homo sapiens_hsa005620.41513154
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41098280
163Alcoholism_Homo sapiens_hsa050340.40986037
164Herpes simplex infection_Homo sapiens_hsa051680.40852364
165Basal cell carcinoma_Homo sapiens_hsa052170.40408568
166SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38410291
167Sulfur metabolism_Homo sapiens_hsa009200.38145489
168Linoleic acid metabolism_Homo sapiens_hsa005910.31970449
169Hematopoietic cell lineage_Homo sapiens_hsa046400.31155692
170Complement and coagulation cascades_Homo sapiens_hsa046100.30620910
171Biosynthesis of amino acids_Homo sapiens_hsa012300.29217599
172Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28107249
173Shigellosis_Homo sapiens_hsa051310.27657215
174Asthma_Homo sapiens_hsa053100.26810946
175Notch signaling pathway_Homo sapiens_hsa043300.26677676
176RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26671075
177Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23699759
178Cell cycle_Homo sapiens_hsa041100.23598102
179Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23125694
180Non-homologous end-joining_Homo sapiens_hsa034500.22777509
181Ether lipid metabolism_Homo sapiens_hsa005650.21912308
182Caffeine metabolism_Homo sapiens_hsa002320.21523909
183Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20602880
184Carbon metabolism_Homo sapiens_hsa012000.20590775
185Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19811004
186Pertussis_Homo sapiens_hsa051330.19278950

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