PPEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)9.31030834
2female mating behavior (GO:0060180)8.05276834
3negative regulation of dendrite morphogenesis (GO:0050774)6.89272150
4tachykinin receptor signaling pathway (GO:0007217)5.98623100
5peripheral nervous system neuron development (GO:0048935)5.77457216
6urinary tract smooth muscle contraction (GO:0014848)5.74690307
7behavioral response to pain (GO:0048266)5.64061635
8neuronal action potential (GO:0019228)5.26891890
9negative regulation of homotypic cell-cell adhesion (GO:0034111)5.16592674
10positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.93987147
11adenosine metabolic process (GO:0046085)4.88259350
12transmission of nerve impulse (GO:0019226)4.82747410
13somite development (GO:0061053)4.82248782
14detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.81269329
15detection of temperature stimulus involved in sensory perception (GO:0050961)4.81269329
16piRNA metabolic process (GO:0034587)4.80646556
17regulation of mesoderm development (GO:2000380)4.78982048
18detection of temperature stimulus (GO:0016048)4.75716028
19regulation of acrosome reaction (GO:0060046)4.74552426
20negative regulation of dendrite development (GO:2000171)4.73550922
21negative regulation of cytosolic calcium ion concentration (GO:0051481)4.63647334
22response to pain (GO:0048265)4.56352750
23acrosome reaction (GO:0007340)4.46739776
24cellular response to ATP (GO:0071318)4.40803983
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.26502227
26regulation of platelet aggregation (GO:0090330)4.25368088
27limb bud formation (GO:0060174)4.16311140
28multicellular organismal reproductive behavior (GO:0033057)4.16058691
29regulation of cell maturation (GO:1903429)4.14826110
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.04193236
31negative regulation of calcium ion transport into cytosol (GO:0010523)3.90538783
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.89956248
33positive regulation of glomerulus development (GO:0090193)3.87962776
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78617198
35neurofilament cytoskeleton organization (GO:0060052)3.77261603
36negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.76393617
37behavioral response to ethanol (GO:0048149)3.71280276
38response to ATP (GO:0033198)3.68855282
39detection of mechanical stimulus involved in sensory perception (GO:0050974)3.66267514
40rRNA catabolic process (GO:0016075)3.63469576
41adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.62518136
42epithelial cilium movement (GO:0003351)3.59915885
43regulation of female gonad development (GO:2000194)3.58217577
44purinergic nucleotide receptor signaling pathway (GO:0035590)3.55475034
45adaptation of signaling pathway (GO:0023058)3.52058057
46phosphatidylethanolamine metabolic process (GO:0046337)3.49892517
47DNA methylation involved in gamete generation (GO:0043046)3.46396725
48positive regulation of potassium ion transmembrane transport (GO:1901381)3.46361959
49membrane depolarization during action potential (GO:0086010)3.46048169
50G-protein coupled receptor internalization (GO:0002031)3.44792817
51inositol phosphate catabolic process (GO:0071545)3.40389113
52protein polyglutamylation (GO:0018095)3.38021566
53phosphatidylethanolamine biosynthetic process (GO:0006646)3.37859846
54serotonin receptor signaling pathway (GO:0007210)3.37319233
55ncRNA catabolic process (GO:0034661)3.27201928
56positive regulation of digestive system process (GO:0060456)3.26604901
57positive regulation of steroid hormone secretion (GO:2000833)3.23853074
58regulation of relaxation of muscle (GO:1901077)3.23413892
59negative regulation of cAMP-mediated signaling (GO:0043951)3.21275236
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19985417
61negative regulation of actin filament bundle assembly (GO:0032232)3.19530186
62negative regulation of stress fiber assembly (GO:0051497)3.18869303
63negative regulation of astrocyte differentiation (GO:0048712)3.17834235
64negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.16672793
65positive regulation of mitochondrial fission (GO:0090141)3.16659842
66regulation of glomerulus development (GO:0090192)3.13556501
67sperm motility (GO:0030317)3.11001598
68protein-chromophore linkage (GO:0018298)3.10935853
69positive regulation of cellular amide metabolic process (GO:0034250)3.10735479
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10570442
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08009677
72positive regulation of heat generation (GO:0031652)3.07875112
73sperm capacitation (GO:0048240)3.07421201
74nephron tubule formation (GO:0072079)3.07370363
75regulation of meiosis I (GO:0060631)3.07027029
76artery development (GO:0060840)3.07025770
77negative regulation of complement activation (GO:0045916)3.06943224
78relaxation of smooth muscle (GO:0044557)3.05366641
79behavioral response to nicotine (GO:0035095)3.04403978
80water-soluble vitamin biosynthetic process (GO:0042364)3.00703904
81multicellular organismal signaling (GO:0035637)2.99025696
82action potential (GO:0001508)2.96575836
83sensory perception of taste (GO:0050909)2.95800456
84regulation of fever generation (GO:0031620)2.95072373
85regulation of homotypic cell-cell adhesion (GO:0034110)2.93848691
86cellular response to nicotine (GO:0071316)2.92584812
87negative regulation of systemic arterial blood pressure (GO:0003085)2.92223777
88peristalsis (GO:0030432)2.92199491
89retinal cone cell development (GO:0046549)2.90209245
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89819007
91cAMP catabolic process (GO:0006198)2.89165742
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86189865
93regulation of mesenchymal cell apoptotic process (GO:2001053)2.85415024
94reproduction (GO:0000003)2.85090670
95respiratory burst (GO:0045730)2.84440770
96multicellular organism reproduction (GO:0032504)2.83721994
97regulation of glucocorticoid metabolic process (GO:0031943)2.81987389
98cell migration in hindbrain (GO:0021535)2.81509150
99calcium ion-dependent exocytosis (GO:0017156)2.81496882
100meiotic cell cycle (GO:0051321)2.79487528
101positive regulation of interleukin-1 production (GO:0032732)2.78880967
102primary amino compound metabolic process (GO:1901160)2.77903529
103multi-organism reproductive behavior (GO:0044705)2.76306314
104prostate gland growth (GO:0060736)2.75589529
105superoxide anion generation (GO:0042554)2.75543797
106lateral sprouting from an epithelium (GO:0060601)2.75472061
107positive regulation of cardiac muscle hypertrophy (GO:0010613)2.73910060
108positive regulation of muscle hypertrophy (GO:0014742)2.73910060
109protein localization to cilium (GO:0061512)2.71923366
110detection of light stimulus involved in sensory perception (GO:0050962)2.71632185
111detection of light stimulus involved in visual perception (GO:0050908)2.71632185
112serotonin metabolic process (GO:0042428)2.71617162
113mitochondrial calcium ion homeostasis (GO:0051560)2.70672231
114spermatid development (GO:0007286)2.70496011
115cilium movement (GO:0003341)2.70324611
116phosphorelay signal transduction system (GO:0000160)2.69728566
117reproductive behavior (GO:0019098)2.69658825
118indolalkylamine metabolic process (GO:0006586)2.69450345
119response to pheromone (GO:0019236)2.69444187
120positive regulation of macrophage differentiation (GO:0045651)2.68491133
121embryonic epithelial tube formation (GO:0001838)2.67962196
122negative regulation of smooth muscle cell differentiation (GO:0051151)2.67250817
123phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67022955
124inositol phosphate dephosphorylation (GO:0046855)2.67022955
125microtubule depolymerization (GO:0007019)2.65608029
126long term synaptic depression (GO:0060292)2.63746007
127* regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63449663
128ADP metabolic process (GO:0046031)2.63367633
129opioid receptor signaling pathway (GO:0038003)2.62634829
130negative regulation of adenylate cyclase activity (GO:0007194)2.62254861
131startle response (GO:0001964)2.61518882
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.61390083
133organ formation (GO:0048645)2.61000730
134DNA damage response, signal transduction resulting in transcription (GO:0042772)2.59942685
135retinal ganglion cell axon guidance (GO:0031290)2.59427754
136sympathetic nervous system development (GO:0048485)2.59342383
137cellular ketone body metabolic process (GO:0046950)2.58716035
138aggressive behavior (GO:0002118)2.58179883
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56566364
140positive regulation of organelle assembly (GO:1902117)2.56041650
141ectoderm development (GO:0007398)2.56038284
142centriole replication (GO:0007099)2.55937161
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55638038
144sleep (GO:0030431)2.55371899
145female gamete generation (GO:0007292)2.53642644
146axoneme assembly (GO:0035082)2.52734374
147negative regulation of sodium ion transport (GO:0010766)2.52404913
148negative regulation of heart rate (GO:0010459)2.51103027
149regulation of DNA methylation (GO:0044030)2.50980634
150transepithelial transport (GO:0070633)2.50689269
151negative regulation of membrane potential (GO:0045837)2.50667957
152microtubule polymerization or depolymerization (GO:0031109)2.50329111
153lung-associated mesenchyme development (GO:0060484)2.49469405
154positive regulation of cAMP-mediated signaling (GO:0043950)2.48203699
155presynaptic membrane assembly (GO:0097105)2.48129032
156epithelial tube formation (GO:0072175)2.47808444
157cyclic nucleotide catabolic process (GO:0009214)2.47804781
158sperm-egg recognition (GO:0035036)2.47701144
159negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.47640412
160microtubule severing (GO:0051013)2.46687964
161vocalization behavior (GO:0071625)2.46605901
162neuron fate specification (GO:0048665)2.46543813
163negative regulation of mast cell activation (GO:0033004)2.46070279
164sequestering of actin monomers (GO:0042989)2.46034695
165regulation of cell communication by electrical coupling (GO:0010649)2.46026350
166* rhodopsin mediated signaling pathway (GO:0016056)2.45908270
167regulation of prostaglandin secretion (GO:0032306)2.45672991
168phasic smooth muscle contraction (GO:0014821)2.44958789
169proline transport (GO:0015824)2.44905357
170regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.44343348
171neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.44087557
172negative regulation of cation channel activity (GO:2001258)2.43160808
173histamine secretion (GO:0001821)2.42061060
174multicellular organismal response to stress (GO:0033555)2.41680268
175bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40909947
176potassium ion export (GO:0071435)2.39287421
177neuromuscular synaptic transmission (GO:0007274)2.38887603
178cellular response to prostaglandin stimulus (GO:0071379)2.38880810
179purinergic receptor signaling pathway (GO:0035587)2.37770545
180protein K11-linked deubiquitination (GO:0035871)2.35735086
181monocyte chemotaxis (GO:0002548)2.35160216
182glycosphingolipid biosynthetic process (GO:0006688)2.28878115
183negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.27764295
184detection of mechanical stimulus (GO:0050982)2.27361591
185response to redox state (GO:0051775)2.26981179
186polyol catabolic process (GO:0046174)2.25753102
187regulation of cardiac muscle hypertrophy (GO:0010611)2.24373157
188regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23949496
189response to water (GO:0009415)2.23013868
190positive regulation of potassium ion transport (GO:0043268)2.22977506

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.61160645
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.11386726
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96748911
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68538014
5TAF15_26573619_Chip-Seq_HEK293_Human2.48267924
6VDR_22108803_ChIP-Seq_LS180_Human2.31262473
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.25429543
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21551940
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18496520
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17840101
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12242297
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11065876
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10323114
14IGF1R_20145208_ChIP-Seq_DFB_Human2.10259227
15P300_19829295_ChIP-Seq_ESCs_Human2.08676877
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01614729
17SMAD4_21799915_ChIP-Seq_A2780_Human1.98884127
18FUS_26573619_Chip-Seq_HEK293_Human1.96727410
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88284342
20ZNF274_21170338_ChIP-Seq_K562_Hela1.85831626
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81518458
22EZH2_22144423_ChIP-Seq_EOC_Human1.81420977
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79949555
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77219245
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75768578
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.74809331
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74548855
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70494065
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.69556657
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68986759
31RNF2_27304074_Chip-Seq_NSC_Mouse1.68024734
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.66683628
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.65843272
34DROSHA_22980978_ChIP-Seq_HELA_Human1.63720426
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62180285
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.61456252
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59890081
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58712551
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58061863
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57385779
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57059867
42AR_25329375_ChIP-Seq_VCAP_Human1.57031197
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56411048
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55574460
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.55184912
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53178985
47KDM2B_26808549_Chip-Seq_REH_Human1.51215965
48P53_22387025_ChIP-Seq_ESCs_Mouse1.50924599
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49651974
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.49454024
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.48469755
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.48167221
53EWS_26573619_Chip-Seq_HEK293_Human1.47952001
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46624542
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46171048
56STAT3_23295773_ChIP-Seq_U87_Human1.40205197
57RXR_22108803_ChIP-Seq_LS180_Human1.39571169
58NMYC_18555785_Chip-Seq_ESCs_Mouse1.38659610
59CBP_20019798_ChIP-Seq_JUKART_Human1.37311196
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37311196
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.36420832
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36177512
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35878569
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.34878995
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34014378
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32384709
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31840141
68P300_18555785_Chip-Seq_ESCs_Mouse1.31223020
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30912318
70BCAT_22108803_ChIP-Seq_LS180_Human1.30114446
71REST_21632747_ChIP-Seq_MESCs_Mouse1.29604225
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29589750
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.28278562
74RUNX2_22187159_ChIP-Seq_PCA_Human1.27891821
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27264154
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26692434
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25509671
78JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24938551
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24704273
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24612371
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.24436052
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24243754
83TCF4_22108803_ChIP-Seq_LS180_Human1.24177873
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24084490
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24057511
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23799555
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23113549
88JUN_21703547_ChIP-Seq_K562_Human1.22979589
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22949303
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22672954
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22672954
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22577825
93ER_23166858_ChIP-Seq_MCF-7_Human1.22077632
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.21862901
95PU1_27457419_Chip-Seq_LIVER_Mouse1.20828409
96TCF4_23295773_ChIP-Seq_U87_Human1.20764433
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.20368184
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.20364166
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.20266291
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20107957
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.20075466
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.17893350
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17806441
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17587168
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16383447
106EED_16625203_ChIP-ChIP_MESCs_Mouse1.15718143
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15352265
108* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15189103
109* SOX2_19829295_ChIP-Seq_ESCs_Human1.14595386
110* NANOG_19829295_ChIP-Seq_ESCs_Human1.14595386
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.14378495
112GF1_26923725_Chip-Seq_HPCs_Mouse1.14249831
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.13997946
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.12867267
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12793259
116CJUN_26792858_Chip-Seq_BT549_Human1.12443260
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12356583
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11400780
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11074140
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10573241
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.09810574
122P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09631266
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09630891
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09626338
125EZH2_27304074_Chip-Seq_ESCs_Mouse1.09101785
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08897272
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08291852
128KLF4_18555785_Chip-Seq_ESCs_Mouse1.07951033
129EP300_21415370_ChIP-Seq_HL-1_Mouse1.07616200
130CBX2_27304074_Chip-Seq_ESCs_Mouse1.07139273
131AHR_22903824_ChIP-Seq_MCF-7_Human1.06858355
132ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06305824
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06117146
134ARNT_22903824_ChIP-Seq_MCF-7_Human1.04956119
135CRX_20693478_ChIP-Seq_RETINA_Mouse1.03611542
136EZH2_27294783_Chip-Seq_ESCs_Mouse1.03507034
137EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03406406
138RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03406406
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02854330
140SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02837686
141* TP53_22573176_ChIP-Seq_HFKS_Human1.02477541
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01799603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.22113432
2MP0001986_abnormal_taste_sensitivity6.82292623
3MP0001968_abnormal_touch/_nociception6.18032027
4MP0009780_abnormal_chondrocyte_physiolo6.01974125
5MP0002736_abnormal_nociception_after5.56392689
6MP0004858_abnormal_nervous_system3.50763557
7MP0002733_abnormal_thermal_nociception3.31421424
8MP0006276_abnormal_autonomic_nervous3.25338962
9MP0002163_abnormal_gland_morphology3.12506931
10MP0004885_abnormal_endolymph3.07957083
11MP0002734_abnormal_mechanical_nocicepti3.04565069
12MP0003136_yellow_coat_color3.00951135
13MP0002102_abnormal_ear_morphology2.83727945
14MP0001970_abnormal_pain_threshold2.71234055
15MP0005646_abnormal_pituitary_gland2.53873175
16MP0009697_abnormal_copulation2.52722548
17MP0002234_abnormal_pharynx_morphology2.51041717
18MP0003879_abnormal_hair_cell2.47491341
19MP0002138_abnormal_hepatobiliary_system2.40575419
20MP0003283_abnormal_digestive_organ2.36441530
21MP0008260_abnormal_autophagy2.35016207
22MP0004270_analgesia2.33439807
23MP0004510_myositis2.33041139
24MP0003195_calcinosis2.32787461
25MP0009053_abnormal_anal_canal2.07902649
26MP0003119_abnormal_digestive_system1.95964038
27MP0003938_abnormal_ear_development1.90350995
28MP0000537_abnormal_urethra_morphology1.87600507
29MP0006292_abnormal_olfactory_placode1.86506851
30MP0000383_abnormal_hair_follicle1.85325312
31MP0002282_abnormal_trachea_morphology1.84620573
32MP0001984_abnormal_olfaction1.80379455
33MP0001188_hyperpigmentation1.72687314
34MP0000569_abnormal_digit_pigmentation1.65914259
35MP0005187_abnormal_penis_morphology1.63639188
36MP0000631_abnormal_neuroendocrine_gland1.62831507
37MP0004130_abnormal_muscle_cell1.58948439
38MP0005379_endocrine/exocrine_gland_phen1.58640456
39MP0002067_abnormal_sensory_capabilities1.57710575
40MP0000372_irregular_coat_pigmentation1.57520045
41MP0000613_abnormal_salivary_gland1.55217291
42MP0010678_abnormal_skin_adnexa1.51105252
43MP0002751_abnormal_autonomic_nervous1.48506001
44MP0002272_abnormal_nervous_system1.47365790
45MP0000749_muscle_degeneration1.45947710
46MP0000049_abnormal_middle_ear1.44539259
47MP0005360_urolithiasis1.42486589
48MP0001835_abnormal_antigen_presentation1.41949107
49MP0001485_abnormal_pinna_reflex1.36317322
50MP0002876_abnormal_thyroid_physiology1.33461718
51MP0002837_dystrophic_cardiac_calcinosis1.33351111
52MP0002184_abnormal_innervation1.31657659
53MP0008872_abnormal_physiological_respon1.30988363
54MP0003656_abnormal_erythrocyte_physiolo1.28831231
55MP0005410_abnormal_fertilization1.26692649
56MP0005503_abnormal_tendon_morphology1.22555142
57MP0002148_abnormal_hypersensitivity_rea1.21287423
58MP0002249_abnormal_larynx_morphology1.20174040
59MP0003183_abnormal_peptide_metabolism1.19138037
60MP0000015_abnormal_ear_pigmentation1.15576862
61MP0003937_abnormal_limbs/digits/tail_de1.11416374
62MP0002254_reproductive_system_inflammat1.10805508
63MP0005670_abnormal_white_adipose1.10352992
64MP0002277_abnormal_respiratory_mucosa1.08706613
65MP0008789_abnormal_olfactory_epithelium1.07278498
66MP0000026_abnormal_inner_ear1.06733004
67MP0005395_other_phenotype0.99896152
68MP0004085_abnormal_heartbeat0.99268710
69MP0002160_abnormal_reproductive_system0.97080671
70MP0002638_abnormal_pupillary_reflex0.95784110
71MP0005671_abnormal_response_to0.95638652
72MP0009785_altered_susceptibility_to0.94982082
73MP0001929_abnormal_gametogenesis0.94320791
74MP0005645_abnormal_hypothalamus_physiol0.94283590
75MP0004145_abnormal_muscle_electrophysio0.93878813
76MP0003724_increased_susceptibility_to0.93632566
77MP0009046_muscle_twitch0.93056799
78MP0001270_distended_abdomen0.92534323
79MP0006072_abnormal_retinal_apoptosis0.90590948
80MP0009745_abnormal_behavioral_response0.88957791
81MP0002557_abnormal_social/conspecific_i0.86076631
82MP0005551_abnormal_eye_electrophysiolog0.85890711
83MP0003787_abnormal_imprinting0.85889080
84MP0000467_abnormal_esophagus_morphology0.85726660
85MP0000427_abnormal_hair_cycle0.83345471
86MP0001664_abnormal_digestion0.82485574
87MP0001293_anophthalmia0.82421233
88MP0002572_abnormal_emotion/affect_behav0.82368553
89MP0002396_abnormal_hematopoietic_system0.82005474
90MP0004782_abnormal_surfactant_physiolog0.81686392
91MP0002210_abnormal_sex_determination0.81620162
92MP0001348_abnormal_lacrimal_gland0.81387194
93MP0002419_abnormal_innate_immunity0.81282597
94MP0001542_abnormal_bone_strength0.81117481
95MP0005464_abnormal_platelet_physiology0.80327047
96MP0000681_abnormal_thyroid_gland0.79488477
97MP0000230_abnormal_systemic_arterial0.79094028
98MP0001905_abnormal_dopamine_level0.77216872
99MP0009764_decreased_sensitivity_to0.77169804
100MP0004484_altered_response_of0.77034686
101MP0003633_abnormal_nervous_system0.75519449
102MP0005391_vision/eye_phenotype0.74726368
103MP0004811_abnormal_neuron_physiology0.74019870
104MP0001501_abnormal_sleep_pattern0.73437904
105MP0000534_abnormal_ureter_morphology0.73396842
106MP0002233_abnormal_nose_morphology0.72933025
107MP0005171_absent_coat_pigmentation0.72805908
108MP0003646_muscle_fatigue0.72332328
109MP0003137_abnormal_impulse_conducting0.71782898
110MP0000653_abnormal_sex_gland0.71414444
111MP0010386_abnormal_urinary_bladder0.70924248
112MP0002909_abnormal_adrenal_gland0.70668712
113MP0004859_abnormal_synaptic_plasticity0.68322550
114MP0008004_abnormal_stomach_pH0.67827063
115MP0002752_abnormal_somatic_nervous0.66813092
116MP0005394_taste/olfaction_phenotype0.66637306
117MP0005499_abnormal_olfactory_system0.66637306
118MP0003942_abnormal_urinary_system0.66424511
119MP0002063_abnormal_learning/memory/cond0.65916618
120MP0001486_abnormal_startle_reflex0.64883314
121MP0002109_abnormal_limb_morphology0.64431927
122MP0002064_seizures0.63922690
123MP0005195_abnormal_posterior_eye0.63862251
124MP0004142_abnormal_muscle_tone0.62766180
125MP0003635_abnormal_synaptic_transmissio0.62669436
126MP0002882_abnormal_neuron_morphology0.61179815
127MP0008775_abnormal_heart_ventricle0.60369229
128MP0001963_abnormal_hearing_physiology0.60230380
129MP0001346_abnormal_lacrimal_gland0.59812520
130MP0004742_abnormal_vestibular_system0.59503982
131MP0002132_abnormal_respiratory_system0.59010925
132MP0003045_fibrosis0.58796577
133MP0005310_abnormal_salivary_gland0.58163995
134MP0001502_abnormal_circadian_rhythm0.57810149
135MP0005397_hematopoietic_system_phenotyp0.57700945
136MP0001545_abnormal_hematopoietic_system0.57700945
137MP0005253_abnormal_eye_physiology0.55885533
138MP0005000_abnormal_immune_tolerance0.55847889
139MP0005423_abnormal_somatic_nervous0.55499676
140MP0003880_abnormal_central_pattern0.54656921
141MP0001440_abnormal_grooming_behavior0.54329094
142MP0003436_decreased_susceptibility_to0.53910039
143MP0005389_reproductive_system_phenotype0.53324889
144MP0004924_abnormal_behavior0.52962966
145MP0005386_behavior/neurological_phenoty0.52962966
146MP0005075_abnormal_melanosome_morpholog0.52864042
147MP0002229_neurodegeneration0.50804847
148MP0000538_abnormal_urinary_bladder0.50418338
149MP0002723_abnormal_immune_serum0.49389173
150MP0008877_abnormal_DNA_methylation0.48828664
151MP0001800_abnormal_humoral_immune0.48669832
152MP0001299_abnormal_eye_distance/0.48011676
153MP0002452_abnormal_antigen_presenting0.47644437
154MP0005647_abnormal_sex_gland0.47378750
155MP0003718_maternal_effect0.47182644
156MP0003698_abnormal_male_reproductive0.46752900

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.66635846
2Thyroid-stimulating hormone excess (HP:0002925)5.28331715
3Febrile seizures (HP:0002373)4.96812381
4Hypothermia (HP:0002045)4.89018586
5Pancreatic cysts (HP:0001737)3.99572856
6Segmental peripheral demyelination/remyelination (HP:0003481)3.85455336
7Submucous cleft hard palate (HP:0000176)3.80713354
8Action tremor (HP:0002345)3.69620798
9Intestinal atresia (HP:0011100)3.64215019
10Severe visual impairment (HP:0001141)3.52622745
11Asplenia (HP:0001746)3.44625480
12Tubular atrophy (HP:0000092)3.41925393
13Prostate neoplasm (HP:0100787)3.38163653
14Dyschromatopsia (HP:0007641)3.36505338
15Abnormality of macular pigmentation (HP:0008002)3.35534477
16Bilateral microphthalmos (HP:0007633)3.34492693
17Attenuation of retinal blood vessels (HP:0007843)3.29132472
18Aplasia/Hypoplasia of the spleen (HP:0010451)3.28910335
19Abnormality of the renal cortex (HP:0011035)3.23872167
20Volvulus (HP:0002580)3.18851365
21Morphological abnormality of the middle ear (HP:0008609)3.18427569
22Aplasia/Hypoplasia of the sternum (HP:0006714)3.16436317
23Long nose (HP:0003189)3.10831345
24Steppage gait (HP:0003376)3.10480031
25Dysautonomia (HP:0002459)3.10321339
26Abnormality of the nasal septum (HP:0000419)3.09550251
27Bradycardia (HP:0001662)3.02941442
28Nephronophthisis (HP:0000090)2.95351361
29Abnormal hair whorl (HP:0010721)2.93476722
30Arthropathy (HP:0003040)2.93404330
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91667162
32Abnormality of the renal medulla (HP:0100957)2.87239250
33Myokymia (HP:0002411)2.86402597
34Failure to thrive in infancy (HP:0001531)2.81874743
35Retrobulbar optic neuritis (HP:0100654)2.79711315
36Optic neuritis (HP:0100653)2.79711315
37Chromsome breakage (HP:0040012)2.76625142
38Abnormal biliary tract physiology (HP:0012439)2.74989885
39Bile duct proliferation (HP:0001408)2.74989885
40Gaze-evoked nystagmus (HP:0000640)2.72767977
41Supernumerary spleens (HP:0009799)2.70304189
42Large for gestational age (HP:0001520)2.70260023
43Abnormality of pain sensation (HP:0010832)2.68147782
44Impaired pain sensation (HP:0007328)2.68147782
45Thyroid carcinoma (HP:0002890)2.65517307
46Irregular epiphyses (HP:0010582)2.65492049
47Renal cortical cysts (HP:0000803)2.64960071
48Absent eyebrow (HP:0002223)2.64621874
49Focal seizures (HP:0007359)2.64509465
50Recurrent abscess formation (HP:0002722)2.62813498
51Chorioretinal atrophy (HP:0000533)2.62759206
52Impaired proprioception (HP:0010831)2.60367359
53Autoamputation (HP:0001218)2.59954445
54Abnormality of midbrain morphology (HP:0002418)2.59578159
55Molar tooth sign on MRI (HP:0002419)2.59578159
56Eczematoid dermatitis (HP:0000976)2.59514500
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58556962
58Anophthalmia (HP:0000528)2.58011314
59Abnormality of the proximal phalanges of the hand (HP:0009834)2.57258611
60Distal lower limb muscle weakness (HP:0009053)2.56914007
61Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.54999475
62Oligodontia (HP:0000677)2.54747179
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.53099279
64Absent/shortened dynein arms (HP:0200106)2.53099279
65Tented upper lip vermilion (HP:0010804)2.51851756
66Bony spicule pigmentary retinopathy (HP:0007737)2.51079597
67Abnormality of the epiphysis of the femoral head (HP:0010574)2.50250596
68Progressive cerebellar ataxia (HP:0002073)2.49710723
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.48598272
70Hypoplasia of the fovea (HP:0007750)2.48598272
71Increased corneal curvature (HP:0100692)2.47317432
72Keratoconus (HP:0000563)2.47317432
73Cystic liver disease (HP:0006706)2.44680634
74Abnormality of the femoral head (HP:0003368)2.44538851
75Hyperthyroidism (HP:0000836)2.43954918
76Optic nerve hypoplasia (HP:0000609)2.43509391
77Medial flaring of the eyebrow (HP:0010747)2.40051848
78Pheochromocytoma (HP:0002666)2.39300508
79Potter facies (HP:0002009)2.37948274
80Facial shape deformation (HP:0011334)2.37948274
81Insidious onset (HP:0003587)2.35603449
82Termporal pattern (HP:0011008)2.35603449
83Hemiparesis (HP:0001269)2.34960189
84Abnormality of femoral epiphyses (HP:0006499)2.34522547
85Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.34522547
86Congenital stationary night blindness (HP:0007642)2.34079547
87Short hallux (HP:0010109)2.32149605
88Foot dorsiflexor weakness (HP:0009027)2.30077700
89Atonic seizures (HP:0010819)2.29234838
90Abnormality of the middle phalanges of the toes (HP:0010183)2.27033881
91Epileptic encephalopathy (HP:0200134)2.23614718
92Concave nail (HP:0001598)2.20976774
93Neuroendocrine neoplasm (HP:0100634)2.18639377
94Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.18463537
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16985789
96Vaginal atresia (HP:0000148)2.15037362
97Recurrent bacterial skin infections (HP:0005406)2.14894288
98Abnormality of the fovea (HP:0000493)2.14373935
99Nephrogenic diabetes insipidus (HP:0009806)2.12784741
100Aplasia/Hypoplasia of the hallux (HP:0008362)2.11488908
101Type II lissencephaly (HP:0007260)2.10867054
102Pigmentary retinal degeneration (HP:0001146)2.10072148
103Vitreoretinal degeneration (HP:0000655)2.09342597
104Aplasia/Hypoplasia of the tongue (HP:0010295)2.07556080
105Mask-like facies (HP:0000298)2.07507023
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07004439
107Synostosis involving the elbow (HP:0003938)2.06168232
108Humeroradial synostosis (HP:0003041)2.06168232
109Focal motor seizures (HP:0011153)2.03960722
110Cutaneous finger syndactyly (HP:0010554)2.03872646
111Orchitis (HP:0100796)2.03673922
112Absent epiphyses (HP:0010577)2.03120456
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03120456
114Hypophosphatemic rickets (HP:0004912)2.02506520
115Bifid tongue (HP:0010297)2.02248807
116Anhidrosis (HP:0000970)2.02141035
117Areflexia of lower limbs (HP:0002522)2.01272313
118Fetal akinesia sequence (HP:0001989)2.00616017
119Abnormality of the phalanges of the 5th finger (HP:0004213)1.99687659
120Enlarged kidneys (HP:0000105)1.99401853
121Lip pit (HP:0100267)1.98873203
122Oligodactyly (hands) (HP:0001180)1.98761317
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96884800
124Short 1st metacarpal (HP:0010034)1.96884800
125Decreased central vision (HP:0007663)1.96267568
126Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95102510
127Goiter (HP:0000853)1.95089538
128Congenital primary aphakia (HP:0007707)1.94870178
129Furrowed tongue (HP:0000221)1.94712413
130Broad-based gait (HP:0002136)1.94520866
131Bicornuate uterus (HP:0000813)1.93793303
132Abnormality of the pubic bones (HP:0003172)1.93122993
133Polydipsia (HP:0001959)1.92749797
134Abnormal drinking behavior (HP:0030082)1.92749797
135Short chin (HP:0000331)1.92678953
136Abnormality of the foot musculature (HP:0001436)1.91874486
137Gait imbalance (HP:0002141)1.90866571
138Cerebellar dysplasia (HP:0007033)1.88441022
139Abolished electroretinogram (ERG) (HP:0000550)1.88024774
140Conical tooth (HP:0000698)1.86573104
141Progressive inability to walk (HP:0002505)1.84796598
142Vertebral compression fractures (HP:0002953)1.84276571
143Neoplasm of the adrenal cortex (HP:0100641)1.83886173
144Midline defect of the nose (HP:0004122)1.83639610
145True hermaphroditism (HP:0010459)1.83558845
146Stomach cancer (HP:0012126)1.83016031
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.82677816
148Genital tract atresia (HP:0001827)1.82275673
149Pancreatic fibrosis (HP:0100732)1.81951259
150Polyuria (HP:0000103)1.81853031
151Congenital sensorineural hearing impairment (HP:0008527)1.81776431
152Pendular nystagmus (HP:0012043)1.81681781
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81349913
154Tubulointerstitial fibrosis (HP:0005576)1.81295233
155Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.81119393
156Photophobia (HP:0000613)1.79630229
157Myositis (HP:0100614)1.79577789
158Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79393291
159Hyperventilation (HP:0002883)1.79154395
160Chin dimple (HP:0010751)1.78884552
161Tetraparesis (HP:0002273)1.77192296
162Choroideremia (HP:0001139)1.75232959
163Keratitis (HP:0000491)1.75170421
164Type 2 muscle fiber atrophy (HP:0003554)1.74972700
165Abnormality of the prostate (HP:0008775)1.74054044
166Decreased motor nerve conduction velocity (HP:0003431)1.72995767
167Astigmatism (HP:0000483)1.72308747
168Abnormality of incisor morphology (HP:0011063)1.71344068
169Myotonia (HP:0002486)1.71097874
170Short tibia (HP:0005736)1.70534589
171Tubulointerstitial nephritis (HP:0001970)1.70053055
172Limited hip movement (HP:0008800)1.69818222
173Abnormal rod and cone electroretinograms (HP:0008323)1.69444534
174Abnormal autonomic nervous system physiology (HP:0012332)1.68845276
175Distal arthrogryposis (HP:0005684)1.68596109
176Clubbing of toes (HP:0100760)1.66626000
177Metaphyseal dysplasia (HP:0100255)1.66532748
178Menstrual irregularities (HP:0000858)1.64837153
179Popliteal pterygium (HP:0009756)1.64234166
180Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.63708242
181Abnormality of proline metabolism (HP:0010907)1.63196849
182Hydroxyprolinuria (HP:0003080)1.63196849
183Aplasia/Hypoplasia of the tibia (HP:0005772)1.62454840
184Short femoral neck (HP:0100864)1.60995801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.18383511
2SIK34.13726077
3RIPK43.33362358
4PRPF4B2.88934644
5MAP2K72.63517574
6MAP3K142.45461156
7SGK22.45406832
8MAP3K122.36906404
9ZAK2.17056340
10STK392.16295794
11TXK2.09231089
12YES12.01276703
13GRK51.97212363
14ACVR1B1.97120033
15EPHA31.93176903
16STK38L1.92543634
17CDK81.78312073
18OXSR11.75374818
19TIE11.74217012
20NEK61.73058751
21SGK4941.72160547
22SGK2231.72160547
23MAPKAPK31.65559120
24PINK11.63640763
25NTRK31.62111200
26AKT31.61456809
27ADRBK21.60299607
28CAMKK21.59659275
29MINK11.58480923
30INSRR1.56827070
31MARK31.56361526
32SGK31.55167800
33TRIM281.54461706
34MAP4K21.53489750
35MATK1.52822817
36CSNK1A1L1.51393128
37MAPK131.50289384
38PIM21.50069944
39MUSK1.49779331
40NUAK11.46729706
41MAP3K91.45705002
42MST41.41579254
43BMPR1B1.40888700
44BMPR21.39955730
45FRK1.34545172
46EPHA41.33006487
47CSNK1G21.32372252
48PIK3CG1.29695140
49CSNK1G31.27871954
50WNK41.26424730
51WNK31.21703046
52TAOK31.21034463
53CSNK1G11.19273421
54TRPM71.18715370
55STK241.16829357
56NTRK11.15909797
57ERBB21.13159752
58LATS21.12673972
59NEK91.10243348
60FGFR21.07498318
61RPS6KA21.05529696
62FGFR31.05512346
63PHKG21.03464634
64PHKG11.03464634
65MARK11.00604809
66BLK0.96725883
67PRKCG0.94801851
68GRK70.93562148
69LMTK20.91408016
70OBSCN0.90724698
71TGFBR10.87322509
72TNIK0.86054601
73IRAK10.83375589
74PNCK0.82606888
75PRKG20.80410823
76PLK20.79504655
77IKBKB0.78712641
78PRKCE0.78421256
79RET0.76790148
80ARAF0.76171958
81ERBB30.74605028
82TLK10.72765806
83ADRBK10.71870165
84FER0.69714461
85TEC0.69091881
86PLK40.68922092
87MAP2K40.67817013
88BCR0.67440308
89PRKCI0.66880729
90CDK50.66360355
91MAP3K60.65406732
92MAP2K60.65274637
93LIMK10.64057623
94PLK30.62790372
95IKBKE0.62774207
96MAP3K40.60606316
97NME10.60532625
98NTRK20.59627316
99BRAF0.58554689
100TAOK20.57519807
101CDK90.55357478
102TYRO30.54455084
103DAPK20.54215395
104TNK20.54000163
105ATM0.52183375
106PAK30.52075232
107BRSK20.51762476
108WEE10.51621147
109ERBB40.50535667
110PLK10.50011358
111DYRK30.49872977
112MAP2K10.47773780
113PKN10.47095303
114CSNK1A10.47071591
115NLK0.47011588
116MAPKAPK50.46676348
117RPS6KB10.46507131
118SYK0.46124204
119STK380.45749457
120CDK30.45424706
121CHUK0.45108389
122KIT0.45035492
123PDK30.44424307
124PDK40.44424307
125JAK10.44031532
126CCNB10.43846545
127PAK60.43775928
128EIF2AK20.43752852
129CSNK1D0.43569826
130MAPKAPK20.43134874
131MAP3K50.42576218
132PTK2B0.42292038
133BUB10.41977564
134PIM10.41969444
135BRSK10.41662446
136ROCK10.40909589
137PRKCZ0.40118628
138KSR20.39613703
139RPS6KA60.39412249
140MKNK20.38967507
141CLK10.38650124
142PRKCA0.38107244
143TGFBR20.37382267
144GRK10.36776254
145ABL10.35290360
146MKNK10.34690564
147RPS6KL10.33992227
148RPS6KC10.33992227
149STK160.33668699
150JAK30.32486147
151STK30.31430643
152PRKCD0.31304438
153PDK10.31139397
154CAMK2A0.30995088
155PRKACA0.30821347
156GSK3B0.30640961
157STK100.30412327
158DYRK20.30033010
159CAMKK10.29883962
160KDR0.29744482
161ATR0.29548075
162PRKG10.29519494
163RPS6KA30.29216781
164MYLK0.29082881
165PDK20.27324459
166CSNK1E0.25868044
167CHEK20.25170867

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.08028042
2Synaptic vesicle cycle_Homo sapiens_hsa047212.73434155
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66589565
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.54459121
5Taste transduction_Homo sapiens_hsa047422.47074417
6Dorso-ventral axis formation_Homo sapiens_hsa043202.22526992
7Olfactory transduction_Homo sapiens_hsa047402.21455749
8Rheumatoid arthritis_Homo sapiens_hsa053232.15892998
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14128759
10GABAergic synapse_Homo sapiens_hsa047272.03607920
11Glycerolipid metabolism_Homo sapiens_hsa005612.00055779
12Graft-versus-host disease_Homo sapiens_hsa053321.95003513
13Collecting duct acid secretion_Homo sapiens_hsa049661.85871267
14Caffeine metabolism_Homo sapiens_hsa002321.80586969
15RNA degradation_Homo sapiens_hsa030181.73234700
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72762782
17Regulation of autophagy_Homo sapiens_hsa041401.71807807
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.69809055
19Butanoate metabolism_Homo sapiens_hsa006501.64888212
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63436073
21Tryptophan metabolism_Homo sapiens_hsa003801.61924242
22Salmonella infection_Homo sapiens_hsa051321.61272240
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60359177
24Phagosome_Homo sapiens_hsa041451.56625805
25Allograft rejection_Homo sapiens_hsa053301.51321870
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.46102723
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43288140
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41899624
29Leishmaniasis_Homo sapiens_hsa051401.41689787
30Gastric acid secretion_Homo sapiens_hsa049711.39799838
31Nitrogen metabolism_Homo sapiens_hsa009101.36927209
32Serotonergic synapse_Homo sapiens_hsa047261.34909050
33Homologous recombination_Homo sapiens_hsa034401.34199301
34Fatty acid biosynthesis_Homo sapiens_hsa000611.33656671
35Prolactin signaling pathway_Homo sapiens_hsa049171.31639297
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29005541
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.27118811
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26513215
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26265758
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26173477
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23841108
42Melanoma_Homo sapiens_hsa052181.23774714
43ABC transporters_Homo sapiens_hsa020101.23231976
44Ovarian steroidogenesis_Homo sapiens_hsa049131.22943939
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.22904934
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22824771
47Basal transcription factors_Homo sapiens_hsa030221.22740402
48Linoleic acid metabolism_Homo sapiens_hsa005911.22556485
49Nicotine addiction_Homo sapiens_hsa050331.19602526
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18366984
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.16289916
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14551633
53Hedgehog signaling pathway_Homo sapiens_hsa043401.12732758
54Renin secretion_Homo sapiens_hsa049241.11779966
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10431864
56Insulin secretion_Homo sapiens_hsa049111.09152896
57Measles_Homo sapiens_hsa051621.08453646
58Legionellosis_Homo sapiens_hsa051341.06990285
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06248889
60Amphetamine addiction_Homo sapiens_hsa050311.05748289
61Tuberculosis_Homo sapiens_hsa051521.04606491
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.03670892
63Oocyte meiosis_Homo sapiens_hsa041141.01081036
64Cocaine addiction_Homo sapiens_hsa050301.00880852
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.00778507
66TNF signaling pathway_Homo sapiens_hsa046681.00659709
67Type I diabetes mellitus_Homo sapiens_hsa049401.00193008
68Hematopoietic cell lineage_Homo sapiens_hsa046400.99628148
69Mineral absorption_Homo sapiens_hsa049780.98522083
70Autoimmune thyroid disease_Homo sapiens_hsa053200.97752437
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97272571
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96248168
73Morphine addiction_Homo sapiens_hsa050320.96166663
74Circadian entrainment_Homo sapiens_hsa047130.95930020
75p53 signaling pathway_Homo sapiens_hsa041150.95696922
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92663721
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92436926
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.92048088
79Retinol metabolism_Homo sapiens_hsa008300.91404099
80African trypanosomiasis_Homo sapiens_hsa051430.90747226
81Influenza A_Homo sapiens_hsa051640.90405532
82Chemokine signaling pathway_Homo sapiens_hsa040620.90100421
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.89203496
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87718902
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87082745
86Long-term depression_Homo sapiens_hsa047300.87076828
87Steroid biosynthesis_Homo sapiens_hsa001000.86743629
88Ether lipid metabolism_Homo sapiens_hsa005650.86700376
89Osteoclast differentiation_Homo sapiens_hsa043800.86011789
90Pertussis_Homo sapiens_hsa051330.85786351
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85528709
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85009186
93Shigellosis_Homo sapiens_hsa051310.84875424
94Basal cell carcinoma_Homo sapiens_hsa052170.83483972
95Cholinergic synapse_Homo sapiens_hsa047250.83088865
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83059771
97Glutamatergic synapse_Homo sapiens_hsa047240.82912761
98Oxytocin signaling pathway_Homo sapiens_hsa049210.82874862
99Dopaminergic synapse_Homo sapiens_hsa047280.79550692
100Inositol phosphate metabolism_Homo sapiens_hsa005620.78357262
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.78205164
102Endometrial cancer_Homo sapiens_hsa052130.78144325
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77564362
104Thyroid cancer_Homo sapiens_hsa052160.72972440
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72615430
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72006105
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.71979915
108Fanconi anemia pathway_Homo sapiens_hsa034600.70860499
109ErbB signaling pathway_Homo sapiens_hsa040120.69912361
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69373808
111Chemical carcinogenesis_Homo sapiens_hsa052040.69224843
112Calcium signaling pathway_Homo sapiens_hsa040200.68938610
113Purine metabolism_Homo sapiens_hsa002300.68744428
114Apoptosis_Homo sapiens_hsa042100.67111159
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66060348
116Pancreatic secretion_Homo sapiens_hsa049720.65672211
117Circadian rhythm_Homo sapiens_hsa047100.63102782
118Asthma_Homo sapiens_hsa053100.62683505
119Toxoplasmosis_Homo sapiens_hsa051450.61960755
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.61698033
121Ras signaling pathway_Homo sapiens_hsa040140.59787629
122Malaria_Homo sapiens_hsa051440.59419864
123Wnt signaling pathway_Homo sapiens_hsa043100.58799040
124Cardiac muscle contraction_Homo sapiens_hsa042600.58504047
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57985683
126Hepatitis B_Homo sapiens_hsa051610.57566523
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57305833
128Sphingolipid metabolism_Homo sapiens_hsa006000.57245050
129Thyroid hormone synthesis_Homo sapiens_hsa049180.56427002
130MAPK signaling pathway_Homo sapiens_hsa040100.55984237
131Non-homologous end-joining_Homo sapiens_hsa034500.54356102
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53424432
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49748216
134Vibrio cholerae infection_Homo sapiens_hsa051100.49270198
135Glioma_Homo sapiens_hsa052140.48517086
136Long-term potentiation_Homo sapiens_hsa047200.48476468
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48043169
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45375164
139Pancreatic cancer_Homo sapiens_hsa052120.45050504
140Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44572623
141Salivary secretion_Homo sapiens_hsa049700.44152599
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.43557737
143FoxO signaling pathway_Homo sapiens_hsa040680.43452493
144Epstein-Barr virus infection_Homo sapiens_hsa051690.43437566
145Arachidonic acid metabolism_Homo sapiens_hsa005900.43164186
146B cell receptor signaling pathway_Homo sapiens_hsa046620.43111464
147Gap junction_Homo sapiens_hsa045400.43004614
148Proteasome_Homo sapiens_hsa030500.42344744
149Acute myeloid leukemia_Homo sapiens_hsa052210.41129598
150Type II diabetes mellitus_Homo sapiens_hsa049300.40995303
151cAMP signaling pathway_Homo sapiens_hsa040240.40743880
152Bile secretion_Homo sapiens_hsa049760.40127982
153Choline metabolism in cancer_Homo sapiens_hsa052310.40099592
154RNA transport_Homo sapiens_hsa030130.38450364
155Renin-angiotensin system_Homo sapiens_hsa046140.37273571
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37043919
157One carbon pool by folate_Homo sapiens_hsa006700.36820407
158Arginine and proline metabolism_Homo sapiens_hsa003300.35034236
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34994159
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34200699
161Histidine metabolism_Homo sapiens_hsa003400.31994141
162Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31833050
163Melanogenesis_Homo sapiens_hsa049160.31819512
164Cysteine and methionine metabolism_Homo sapiens_hsa002700.31426796
165TGF-beta signaling pathway_Homo sapiens_hsa043500.29216655

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