PPFIA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.03026817
2mitotic sister chromatid cohesion (GO:0007064)4.66815361
3nuclear pore organization (GO:0006999)4.52961660
4monoubiquitinated protein deubiquitination (GO:0035520)4.33413172
5cytoplasmic mRNA processing body assembly (GO:0033962)4.20003818
6mitotic chromosome condensation (GO:0007076)3.85966354
7regulation of RNA export from nucleus (GO:0046831)3.84668190
8pre-miRNA processing (GO:0031054)3.84078526
9histone H3-K36 demethylation (GO:0070544)3.75874382
10pore complex assembly (GO:0046931)3.75726636
11paraxial mesoderm development (GO:0048339)3.60306905
12histone H2A monoubiquitination (GO:0035518)3.54822986
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.48573412
14regulation of mitotic spindle organization (GO:0060236)3.41213554
15regulation of spindle organization (GO:0090224)3.39477066
16negative regulation of histone methylation (GO:0031061)3.33659853
17iron ion import (GO:0097286)3.29604418
18corticosteroid receptor signaling pathway (GO:0031958)3.27250759
19NLS-bearing protein import into nucleus (GO:0006607)3.22838906
20regulation of hippo signaling (GO:0035330)3.22653606
21regulation of sister chromatid cohesion (GO:0007063)3.19918981
22histone lysine demethylation (GO:0070076)3.18224550
23glucocorticoid receptor signaling pathway (GO:0042921)3.15767992
24growth hormone receptor signaling pathway (GO:0060396)3.10206947
25regulation of nucleobase-containing compound transport (GO:0032239)3.09395053
26negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.09154577
27histone H3-K4 methylation (GO:0051568)3.04658425
28mitotic metaphase plate congression (GO:0007080)3.03510615
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.03448230
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03448230
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03448230
32sister chromatid cohesion (GO:0007062)3.02461775
33fibroblast migration (GO:0010761)3.00763642
34histone demethylation (GO:0016577)3.00386663
35cell-substrate adherens junction assembly (GO:0007045)2.98788080
36focal adhesion assembly (GO:0048041)2.98788080
37regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.98731751
38regulation of NFAT protein import into nucleus (GO:0051532)2.98464440
39hemidesmosome assembly (GO:0031581)2.97770974
40mitotic nuclear envelope disassembly (GO:0007077)2.96642806
41gene silencing by RNA (GO:0031047)2.95185418
42cell-substrate junction assembly (GO:0007044)2.94833164
43histone H3-K9 demethylation (GO:0033169)2.92416872
44regulation of transforming growth factor beta2 production (GO:0032909)2.92340497
45TOR signaling (GO:0031929)2.92150172
46hippo signaling (GO:0035329)2.91497420
47peptidyl-lysine dimethylation (GO:0018027)2.87431180
48adherens junction assembly (GO:0034333)2.86852194
49desmosome organization (GO:0002934)2.86233657
50protein localization to kinetochore (GO:0034501)2.86048199
51DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.85209178
52metaphase plate congression (GO:0051310)2.83472461
53negative regulation of keratinocyte proliferation (GO:0010839)2.81855622
54epithelial cell-cell adhesion (GO:0090136)2.79672744
55nuclear envelope disassembly (GO:0051081)2.79537633
56membrane disassembly (GO:0030397)2.79537633
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74889704
58positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.73555022
59notochord development (GO:0030903)2.73508598
60histone H3-K9 methylation (GO:0051567)2.70917967
61genitalia morphogenesis (GO:0035112)2.70751562
62semaphorin-plexin signaling pathway (GO:0071526)2.69205090
63protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.68916072
64coronary vasculature morphogenesis (GO:0060977)2.68481628
65interkinetic nuclear migration (GO:0022027)2.67522450
66histone lysine methylation (GO:0034968)2.66739855
67positive regulation of chromosome segregation (GO:0051984)2.65989016
68response to UV-C (GO:0010225)2.65888994
69Golgi transport vesicle coating (GO:0048200)2.65717165
70COPI coating of Golgi vesicle (GO:0048205)2.65717165
71heterochromatin organization (GO:0070828)2.65351807
72RNA stabilization (GO:0043489)2.63278892
73mRNA stabilization (GO:0048255)2.63278892
74protein dealkylation (GO:0008214)2.63080253
75protein demethylation (GO:0006482)2.63080253
76regulation of early endosome to late endosome transport (GO:2000641)2.62874330
77DNA damage response, signal transduction resulting in transcription (GO:0042772)2.62423500
78positive regulation of histone deacetylation (GO:0031065)2.60356147
79cellular response to growth hormone stimulus (GO:0071378)2.59966446
80regulation of protein polyubiquitination (GO:1902914)2.59842390
81protein localization to chromosome, centromeric region (GO:0071459)2.57837648
82gene silencing (GO:0016458)2.57249674
83glomerular visceral epithelial cell development (GO:0072015)2.56309206
84peptidyl-lysine trimethylation (GO:0018023)2.53760458
85sister chromatid segregation (GO:0000819)2.51257679
86early endosome to late endosome transport (GO:0045022)2.49634815
87dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49126821
88histone H3-K9 modification (GO:0061647)2.48618115
89regulation of DNA endoreduplication (GO:0032875)2.47736163
90positive regulation of macroautophagy (GO:0016239)2.46524823
91histone H3-K4 trimethylation (GO:0080182)2.46519034
92intestinal epithelial cell development (GO:0060576)2.45712437
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.43984446
94endothelial cell chemotaxis (GO:0035767)2.43656503
95oocyte development (GO:0048599)2.42909840
96protein localization to endosome (GO:0036010)2.42752188
97retina vasculature morphogenesis in camera-type eye (GO:0061299)2.42305803
98regulation of histone H3-K9 methylation (GO:0051570)2.42052350
99positive regulation of gene expression, epigenetic (GO:0045815)2.41846991
100regulation of histone H3-K27 methylation (GO:0061085)2.41534733
101dosage compensation (GO:0007549)2.41301210
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.40001298
103positive regulation of blood vessel endothelial cell migration (GO:0043536)2.39760904
104regulation of establishment of cell polarity (GO:2000114)2.38837135
105histone H2A ubiquitination (GO:0033522)2.38663694
106meiotic chromosome segregation (GO:0045132)2.38416881
107protein localization to chromosome (GO:0034502)2.38233368
108regulation of centriole replication (GO:0046599)2.37779730
109nuclear envelope organization (GO:0006998)2.36735675
110DNA damage induced protein phosphorylation (GO:0006975)2.36009130
111inner cell mass cell proliferation (GO:0001833)2.35978757
112positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.35854280
113negative regulation of histone modification (GO:0031057)2.35749515
114regulation of ARF GTPase activity (GO:0032312)2.35396803
115kinetochore organization (GO:0051383)2.34747605
116cell adhesion mediated by integrin (GO:0033627)2.34472791
117activation of Rac GTPase activity (GO:0032863)2.33547036
118chromatin assembly (GO:0031497)2.33028435
119histone mRNA catabolic process (GO:0071044)2.32461704
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.31887242
121intracellular estrogen receptor signaling pathway (GO:0030520)2.31046362
122regulation of retinoic acid receptor signaling pathway (GO:0048385)2.30805042
123embryonic camera-type eye development (GO:0031076)2.30468781
124embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30099641
125DNA methylation (GO:0006306)2.29603380
126DNA alkylation (GO:0006305)2.29603380
127negative regulation of DNA repair (GO:0045738)2.29384627
128establishment of chromosome localization (GO:0051303)2.28487725
129positive regulation of catenin import into nucleus (GO:0035413)2.26931412
130positive regulation of protein localization to plasma membrane (GO:1903078)2.26766751
131positive regulation of extracellular matrix organization (GO:1903055)2.26088664
132regulation of DNA methylation (GO:0044030)2.25310168
133negative regulation of fatty acid transport (GO:2000192)2.25260139
134hypotonic response (GO:0006971)2.24634379
135histone methylation (GO:0016571)2.24438163
136positive regulation of DNA-templated transcription, initiation (GO:2000144)2.22802295
137regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.22357185
138embryonic camera-type eye morphogenesis (GO:0048596)2.21766043
139microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.21749443
140synaptonemal complex assembly (GO:0007130)2.21738662
141regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.21132294
142embryonic foregut morphogenesis (GO:0048617)2.19490588
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19331799
144embryonic eye morphogenesis (GO:0048048)2.19039675
145positive regulation of DNA-dependent DNA replication (GO:2000105)2.17390667
146meiotic cell cycle (GO:0051321)2.17334894
147branching involved in mammary gland duct morphogenesis (GO:0060444)2.17070644
148histone H2B ubiquitination (GO:0033523)2.16152375
149chromosome condensation (GO:0030261)2.14749464
150RNA localization (GO:0006403)2.10537494
151chondrocyte development (GO:0002063)2.10522643
152nucleus organization (GO:0006997)2.10348404
153cellular protein complex localization (GO:0034629)2.09852915
154regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.09693735
155ectoderm development (GO:0007398)2.08048254
156response to acidic pH (GO:0010447)2.06295892
157mammary gland epithelial cell proliferation (GO:0033598)2.06058051
158Leydig cell differentiation (GO:0033327)2.06023724
159regulation of acrosome reaction (GO:0060046)2.04916877
160cellular response to epidermal growth factor stimulus (GO:0071364)2.04349144
161positive regulation of receptor recycling (GO:0001921)2.03694842
162glomerular epithelial cell development (GO:0072310)2.03297664
163positive regulation of adherens junction organization (GO:1903393)2.02186404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.48414453
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.44951661
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.07128282
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.34659829
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.48436325
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.37179950
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19068218
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88829298
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.78438171
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.76167782
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.60596554
12MYC_22102868_ChIP-Seq_BL_Human2.50716697
13AHR_22903824_ChIP-Seq_MCF-7_Human2.36929307
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35736268
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.18658574
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.18577060
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14483223
18AR_21909140_ChIP-Seq_LNCAP_Human2.11255785
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09426818
20TCF7_22412390_ChIP-Seq_EML_Mouse1.95713559
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94733062
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.91071546
23EZH2_22144423_ChIP-Seq_EOC_Human1.87684550
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87129638
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.78218079
26FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.77912689
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74950506
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74359991
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74359991
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74359991
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.74286375
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72994110
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70651176
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69901406
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64896296
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59051832
37BRD4_25478319_ChIP-Seq_HGPS_Human1.57215781
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.56965960
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54933084
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54328299
41ZNF263_19887448_ChIP-Seq_K562_Human1.53664672
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53549520
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.52084093
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51298438
45KDM2B_26808549_Chip-Seq_DND41_Human1.49430235
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.49262879
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.48260827
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48206414
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47208264
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46607736
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46528270
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45612143
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.43774437
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39113160
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.38630482
56ATF3_27146783_Chip-Seq_COLON_Human1.35251095
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31409996
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31380909
59GATA6_25053715_ChIP-Seq_YYC3_Human1.31084574
60GATA1_22025678_ChIP-Seq_K562_Human1.30296422
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30081381
62* RACK7_27058665_Chip-Seq_MCF-7_Human1.29444699
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.29187644
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29153520
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27322905
66CJUN_26792858_Chip-Seq_BT549_Human1.25938460
67CLOCK_20551151_ChIP-Seq_293T_Human1.25786414
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25031655
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24995415
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24452437
71* UBF1/2_26484160_Chip-Seq_HMECs_Human1.23691206
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23233381
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23233381
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23092961
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21984521
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21541619
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21524915
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19849941
79KLF5_25053715_ChIP-Seq_YYC3_Human1.19469928
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19240868
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19175725
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19045171
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17788217
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.17699174
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.17153420
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16774343
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16655192
88CHD1_26751641_Chip-Seq_LNCaP_Human1.13513031
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13480440
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12707953
91TP53_16413492_ChIP-PET_HCT116_Human1.11736144
92NCOR1_26117541_ChIP-Seq_K562_Human1.11181008
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.10400000
94FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09580958
95MYB_26560356_Chip-Seq_TH1_Human1.09354826
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09229722
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09100100
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08780879
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.08711977
100UTX_26944678_Chip-Seq_JUKART_Human1.07524360
101CIITA_25753668_ChIP-Seq_RAJI_Human1.06788343
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05840906
103PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04683740
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04474598
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04302167
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.04300207
107SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04183470
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04158875
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03599349
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02935620
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02184440
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01676874
113* MITF_21258399_ChIP-Seq_MELANOMA_Human1.01547948
114ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01287822
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01212279
116* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01070573
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.00493140
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00489928
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00470213
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.99282749
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98797636
122MAF_26560356_Chip-Seq_TH1_Human0.98778004
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98748086
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.98554685
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.97886049
126GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97864635
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97646972
128VDR_21846776_ChIP-Seq_THP-1_Human0.97400107
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97381576
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97314931
131KDM5A_27292631_Chip-Seq_BREAST_Human0.96278140
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.96231488
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.96231488
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96120686
135ELK3_25401928_ChIP-Seq_HUVEC_Human0.95586253
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95508333
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.95060525
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93905988
139* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93690511
140KDM2B_26808549_Chip-Seq_K562_Human0.93306434
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91729132
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91298670
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90891954
144MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90479539
145CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90151672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004233_abnormal_muscle_weight3.41451669
2MP0003705_abnormal_hypodermis_morpholog3.26324980
3MP0005409_darkened_coat_color3.11205935
4MP0010352_gastrointestinal_tract_polyps2.89858780
5MP0000569_abnormal_digit_pigmentation2.85442041
6MP0005076_abnormal_cell_differentiation2.85061971
7MP0010307_abnormal_tumor_latency2.41751564
8MP0003136_yellow_coat_color2.31843374
9MP0009780_abnormal_chondrocyte_physiolo2.30757047
10MP0003111_abnormal_nucleus_morphology2.26212928
11MP0003693_abnormal_embryo_hatching2.10752098
12MP0003300_gastrointestinal_ulcer2.10004018
13MP0003077_abnormal_cell_cycle2.05633697
14MP0003950_abnormal_plasma_membrane2.02174937
15MP0003566_abnormal_cell_adhesion1.89099638
16MP0010094_abnormal_chromosome_stability1.84707933
17MP0004381_abnormal_hair_follicle1.84590794
18MP0002877_abnormal_melanocyte_morpholog1.83598116
19MP0008007_abnormal_cellular_replicative1.81118915
20MP0004185_abnormal_adipocyte_glucose1.77302913
21MP0008004_abnormal_stomach_pH1.71904961
22MP0001672_abnormal_embryogenesis/_devel1.62361538
23MP0005380_embryogenesis_phenotype1.62361538
24MP0008057_abnormal_DNA_replication1.62152133
25MP0001730_embryonic_growth_arrest1.62095571
26MP0003984_embryonic_growth_retardation1.61405427
27MP0010030_abnormal_orbit_morphology1.60680934
28MP0009840_abnormal_foam_cell1.60254199
29MP0000733_abnormal_muscle_development1.60171019
30MP0000350_abnormal_cell_proliferation1.59838159
31MP0001849_ear_inflammation1.58993268
32MP0002088_abnormal_embryonic_growth/wei1.58234518
33MP0003878_abnormal_ear_physiology1.57143702
34MP0005377_hearing/vestibular/ear_phenot1.57143702
35MP0009278_abnormal_bone_marrow1.55507360
36MP0000371_diluted_coat_color1.55492933
37MP0004808_abnormal_hematopoietic_stem1.54455182
38MP0008877_abnormal_DNA_methylation1.53072719
39MP0000015_abnormal_ear_pigmentation1.50455489
40MP0003718_maternal_effect1.50318858
41MP0004264_abnormal_extraembryonic_tissu1.47856155
42MP0002086_abnormal_extraembryonic_tissu1.45526737
43MP0005171_absent_coat_pigmentation1.44824511
44MP0003890_abnormal_embryonic-extraembry1.44794703
45MP0002084_abnormal_developmental_patter1.43695633
46MP0002089_abnormal_postnatal_growth/wei1.40938510
47MP0005451_abnormal_body_composition1.40353971
48MP0002396_abnormal_hematopoietic_system1.39331788
49MP0002796_impaired_skin_barrier1.38293432
50MP0005257_abnormal_intraocular_pressure1.36976276
51MP0004197_abnormal_fetal_growth/weight/1.36107877
52MP0003045_fibrosis1.31262237
53MP0002085_abnormal_embryonic_tissue1.31057095
54MP0005397_hematopoietic_system_phenotyp1.29868413
55MP0001545_abnormal_hematopoietic_system1.29868413
56MP0010234_abnormal_vibrissa_follicle1.29423034
57MP0000383_abnormal_hair_follicle1.28272103
58MP0001697_abnormal_embryo_size1.28155353
59MP0005275_abnormal_skin_tensile1.27948192
60MP0003091_abnormal_cell_migration1.27557175
61MP0005023_abnormal_wound_healing1.25139204
62MP0004957_abnormal_blastocyst_morpholog1.24592381
63MP0002896_abnormal_bone_mineralization1.22611769
64MP0000762_abnormal_tongue_morphology1.21310554
65MP0005058_abnormal_lysosome_morphology1.21036829
66MP0006138_congestive_heart_failure1.20962847
67MP0005408_hypopigmentation1.20831262
68MP0008438_abnormal_cutaneous_collagen1.20148411
69MP0009703_decreased_birth_body1.19532681
70MP0000579_abnormal_nail_morphology1.17101724
71MP0003935_abnormal_craniofacial_develop1.15934935
72MP0000428_abnormal_craniofacial_morphol1.15810310
73MP0008260_abnormal_autophagy1.15746472
74MP0010678_abnormal_skin_adnexa1.14459469
75MP0009672_abnormal_birth_weight1.14176331
76MP0002925_abnormal_cardiovascular_devel1.13469918
77MP0003567_abnormal_fetal_cardiomyocyte1.11882226
78MP0003787_abnormal_imprinting1.11107756
79MP0000432_abnormal_head_morphology1.10484454
80MP0005174_abnormal_tail_pigmentation1.08844492
81MP0001915_intracranial_hemorrhage1.08018679
82MP0000003_abnormal_adipose_tissue1.07486674
83MP0003828_pulmonary_edema1.06527611
84MP0003121_genomic_imprinting1.06185944
85MP0003937_abnormal_limbs/digits/tail_de1.06016063
86MP0009053_abnormal_anal_canal1.05632985
87MP0010630_abnormal_cardiac_muscle1.05065301
88MP0000767_abnormal_smooth_muscle1.04503289
89MP0003123_paternal_imprinting1.04011064
90MP0003879_abnormal_hair_cell1.02718669
91MP0002269_muscular_atrophy1.02553482
92MP0003941_abnormal_skin_development1.01633725
93MP0003115_abnormal_respiratory_system1.00748029
94MP0000678_abnormal_parathyroid_gland1.00421285
95MP0009384_cardiac_valve_regurgitation0.98611244
96MP0003453_abnormal_keratinocyte_physiol0.98506360
97MP0004084_abnormal_cardiac_muscle0.97695317
98MP0002080_prenatal_lethality0.97567521
99MP0004782_abnormal_surfactant_physiolog0.94960864
100MP0005666_abnormal_adipose_tissue0.94465088
101MP0005375_adipose_tissue_phenotype0.94395442
102MP0005621_abnormal_cell_physiology0.94166673
103MP0002006_tumorigenesis0.93755240
104MP0000627_abnormal_mammary_gland0.93086767
105MP0003303_peritoneal_inflammation0.92201980
106MP0005187_abnormal_penis_morphology0.91168319
107MP0000266_abnormal_heart_morphology0.90528768
108MP0008058_abnormal_DNA_repair0.90325222
109MP0005395_other_phenotype0.90092822
110MP0000647_abnormal_sebaceous_gland0.89705976
111MP0002075_abnormal_coat/hair_pigmentati0.89705393
112MP0003755_abnormal_palate_morphology0.89051759
113MP0002166_altered_tumor_susceptibility0.88778274
114MP0000537_abnormal_urethra_morphology0.88280612
115MP0003385_abnormal_body_wall0.88009952
116MP0000490_abnormal_crypts_of0.88002496
117MP0005248_abnormal_Harderian_gland0.86507443
118MP0002060_abnormal_skin_morphology0.85901601
119MP0002098_abnormal_vibrissa_morphology0.84745680
120MP0001324_abnormal_eye_pigmentation0.83593296
121MP0005367_renal/urinary_system_phenotyp0.83243754
122MP0000516_abnormal_urinary_system0.83243754
123MP0000534_abnormal_ureter_morphology0.81046163
124MP0003943_abnormal_hepatobiliary_system0.80911241
125MP0008961_abnormal_basal_metabolism0.79898079
126MP0004272_abnormal_basement_membrane0.79479789
127MP0000377_abnormal_hair_follicle0.78846225
128MP0003172_abnormal_lysosome_physiology0.78203753
129MP0003936_abnormal_reproductive_system0.78196643
130MP0005503_abnormal_tendon_morphology0.77768642
131MP0001186_pigmentation_phenotype0.77603378
132MP0000462_abnormal_digestive_system0.77136916
133MP0002697_abnormal_eye_size0.76907942
134MP0001299_abnormal_eye_distance/0.76437961
135MP0002092_abnormal_eye_morphology0.76129012
136MP0003699_abnormal_female_reproductive0.75649004
137MP0005197_abnormal_uvea_morphology0.75008083
138MP0009115_abnormal_fat_cell0.74832661
139MP0001119_abnormal_female_reproductive0.74767015
140MP0002168_other_aberrant_phenotype0.74190421
141MP0005623_abnormal_meninges_morphology0.74123209
142MP0005508_abnormal_skeleton_morphology0.74061786
143MP0001784_abnormal_fluid_regulation0.73714474
144MP0001216_abnormal_epidermal_layer0.72593020
145MP0000427_abnormal_hair_cycle0.72155330

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.00230498
2Long eyelashes (HP:0000527)2.87118594
3Shallow orbits (HP:0000586)2.86487122
4Papillary thyroid carcinoma (HP:0002895)2.82348341
5Cerebral aneurysm (HP:0004944)2.66201988
6Volvulus (HP:0002580)2.65967038
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63954404
8Short 4th metacarpal (HP:0010044)2.63954404
9Chromsome breakage (HP:0040012)2.60995805
10Enlarged penis (HP:0000040)2.45728789
11Cervical subluxation (HP:0003308)2.44092922
12Aplasia cutis congenita (HP:0001057)2.42917519
13Aortic aneurysm (HP:0004942)2.38856988
14Hypoplasia of the iris (HP:0007676)2.34895291
15Ectopic kidney (HP:0000086)2.34470139
16Osteolytic defects of the phalanges of the hand (HP:0009771)2.33724469
17Osteolytic defects of the hand bones (HP:0009699)2.33724469
18Narrow palate (HP:0000189)2.33635072
19Ankle contracture (HP:0006466)2.32658289
20Protrusio acetabuli (HP:0003179)2.30705898
21Subacute progressive viral hepatitis (HP:0006572)2.30269991
22Dysmetric saccades (HP:0000641)2.30049949
23Aneurysm (HP:0002617)2.29229733
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28743474
25Lip pit (HP:0100267)2.28156763
26Acute myeloid leukemia (HP:0004808)2.26935113
27Flat acetabular roof (HP:0003180)2.26426415
28Macroorchidism (HP:0000053)2.22651270
29Advanced eruption of teeth (HP:0006288)2.21763963
30Facial hemangioma (HP:0000329)2.18165805
31Blue irides (HP:0000635)2.13821817
32Malignant gastrointestinal tract tumors (HP:0006749)2.12277178
33Gastrointestinal carcinoma (HP:0002672)2.12277178
34Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.08540666
35Trigonocephaly (HP:0000243)2.07144134
36Mitral valve prolapse (HP:0001634)2.05634377
37Abnormality of the 4th metacarpal (HP:0010012)2.03315131
38Ankyloglossia (HP:0010296)2.02976944
39Rectal prolapse (HP:0002035)2.00297584
40Prominent nose (HP:0000448)1.99386908
41Heterotopia (HP:0002282)1.98968827
42Truncal obesity (HP:0001956)1.98872351
43Leiomyosarcoma (HP:0100243)1.98748195
44Uterine leiomyosarcoma (HP:0002891)1.98748195
45Overgrowth (HP:0001548)1.98671095
46Abnormal auditory evoked potentials (HP:0006958)1.98368155
47Generalized hypopigmentation of hair (HP:0011358)1.97758498
48Abnormality of the salivary glands (HP:0010286)1.95425781
49Spondylolisthesis (HP:0003302)1.95284515
50Transitional cell carcinoma of the bladder (HP:0006740)1.95139220
51Deviation of the thumb (HP:0009603)1.95064293
52Vertebral arch anomaly (HP:0008438)1.94615760
53Oligodontia (HP:0000677)1.94423377
54Bilateral sensorineural hearing impairment (HP:0008619)1.93181119
55Aortic dissection (HP:0002647)1.92967123
56Abnormality of the nasal septum (HP:0000419)1.92273031
57Urethral obstruction (HP:0000796)1.91028793
58Underdeveloped nasal alae (HP:0000430)1.90927419
59Cubitus valgus (HP:0002967)1.90761252
60Anterior segment dysgenesis (HP:0007700)1.90025562
61Hypopigmentation of the fundus (HP:0007894)1.89966780
62Broad palm (HP:0001169)1.88779172
63Relative macrocephaly (HP:0004482)1.87714131
64Broad thumb (HP:0011304)1.87483022
65Spinal cord lesions (HP:0100561)1.86949052
66Syringomyelia (HP:0003396)1.86949052
67Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83783415
68Prostate neoplasm (HP:0100787)1.83398564
69Bladder carcinoma (HP:0002862)1.82349899
70Bladder neoplasm (HP:0009725)1.82349899
71Shawl scrotum (HP:0000049)1.81337392
72Persistence of primary teeth (HP:0006335)1.81001260
73Hyperacusis (HP:0010780)1.80893610
74Germ cell neoplasia (HP:0100728)1.80531342
75Wormian bones (HP:0002645)1.80175019
76Midline defect of the nose (HP:0004122)1.80148138
77Skull defect (HP:0001362)1.79966486
78Blepharitis (HP:0000498)1.78526212
79Deep philtrum (HP:0002002)1.78058650
80Genu recurvatum (HP:0002816)1.77450867
81Hypoplastic labia majora (HP:0000059)1.77170802
82Proximal placement of thumb (HP:0009623)1.76051727
83Sandal gap (HP:0001852)1.75959199
84Limited elbow extension (HP:0001377)1.74919989
85Dislocated radial head (HP:0003083)1.74336534
86Anal stenosis (HP:0002025)1.73759333
87Impulsivity (HP:0100710)1.73625355
88Abnormality of the ischium (HP:0003174)1.73206067
89Low anterior hairline (HP:0000294)1.72852973
90Missing ribs (HP:0000921)1.72405881
91Increased nuchal translucency (HP:0010880)1.72270015
92Vascular tortuosity (HP:0004948)1.68744773
93Male infertility (HP:0003251)1.68729520
94Right ventricular cardiomyopathy (HP:0011663)1.68650506
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.68582093
96Abnormality of chromosome stability (HP:0003220)1.68385037
97Genetic anticipation (HP:0003743)1.68202269
98Curly hair (HP:0002212)1.67836743
99Nephroblastoma (Wilms tumor) (HP:0002667)1.67325975
100Hematochezia (HP:0002573)1.67269316
101Mitral stenosis (HP:0001718)1.67168986
102Cerebral inclusion bodies (HP:0100314)1.66974398
103Hypoplastic ischia (HP:0003175)1.66284138
104Hyperglycemia (HP:0003074)1.66130349
105Ocular albinism (HP:0001107)1.65634413
106Premature rupture of membranes (HP:0001788)1.65385089
107Microglossia (HP:0000171)1.65029164
108Arterial tortuosity (HP:0005116)1.64772351
109Oligodactyly (HP:0012165)1.64103985
110Selective tooth agenesis (HP:0001592)1.63677614
111Neonatal hypoglycemia (HP:0001998)1.63394026
112Sparse lateral eyebrow (HP:0005338)1.63333808
113High anterior hairline (HP:0009890)1.63237293
114Abnormality of the radial head (HP:0003995)1.62578662
115Thin bony cortex (HP:0002753)1.61684078
116Biliary tract neoplasm (HP:0100574)1.61423640
117Spinal cord compression (HP:0002176)1.61187929
118Renal cell carcinoma (HP:0005584)1.61076112
119Tibial bowing (HP:0002982)1.60541523
120Short nail (HP:0001799)1.60540141
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60050632
122Dental malocclusion (HP:0000689)1.59665239
123Septate vagina (HP:0001153)1.59578887
124Natal tooth (HP:0000695)1.59462508
125Exostoses (HP:0100777)1.59274392
126Renovascular hypertension (HP:0100817)1.58325173
127Increased connective tissue (HP:0009025)1.58024648
128Asymmetry of the thorax (HP:0001555)1.57423015
129Bell-shaped thorax (HP:0001591)1.56804786
130Dilatation of the ascending aorta (HP:0005111)1.55919325
131Bronchomalacia (HP:0002780)1.55858042
132Obsessive-compulsive behavior (HP:0000722)1.55723333
133Spinal rigidity (HP:0003306)1.55242176
134Astrocytoma (HP:0009592)1.55067182
135Abnormality of the astrocytes (HP:0100707)1.55067182
136Abnormality of the labia majora (HP:0012881)1.54988998
137Aplasia/Hypoplasia of the macula (HP:0008059)1.54588796
138Thick eyebrow (HP:0000574)1.54339643
139Disproportionate tall stature (HP:0001519)1.54305648
140Ulnar bowing (HP:0003031)1.53842253
141Broad phalanges of the hand (HP:0009768)1.53602806
142Embryonal renal neoplasm (HP:0011794)1.53597819
143Insidious onset (HP:0003587)1.53475959
144Termporal pattern (HP:0011008)1.53475959
145Wrist flexion contracture (HP:0001239)1.52490295
146Neurofibrillary tangles (HP:0002185)1.52196400
147Fair hair (HP:0002286)1.51766211
148Increased density of long bones (HP:0006392)1.51269345
149Atrophic scars (HP:0001075)1.50918511
150Hyporeflexia of lower limbs (HP:0002600)1.50322931
151Broad face (HP:0000283)1.49581310
152Abnormality of the anterior chamber (HP:0000593)1.49465056
153Myocardial infarction (HP:0001658)1.49031064
154Short 1st metacarpal (HP:0010034)1.48076476
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.48076476
156Abnormality of chromosome segregation (HP:0002916)1.47940589
157Oligodactyly (hands) (HP:0001180)1.47505532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.54942539
2CDK124.28980552
3TRIB32.98693130
4MST1R2.93411982
5MET2.83727319
6STK32.77690626
7ICK2.54117070
8PNCK2.48868704
9CDC72.33752664
10STK38L2.28723026
11STK392.22171665
12EEF2K2.20820935
13CAMK1D2.10285714
14LATS22.09983690
15MAP3K132.02889310
16TAOK31.97331038
17NEK21.93762814
18PKN21.87872098
19IRAK31.82960237
20MAP3K91.80687049
21PDGFRA1.79272587
22NEK61.77761154
23BRSK21.73431951
24STK101.63805212
25CAMK1G1.56416747
26DMPK1.56283791
27BRD41.54672111
28TTN1.53088933
29MTOR1.50269651
30PTK61.44892136
31NUAK11.44190643
32PDGFRB1.43990903
33MAP3K101.43339964
34MELK1.38575622
35CDK41.33885700
36TTK1.31095047
37CDK91.28005578
38EPHA21.23671484
39RIPK11.23371139
40FGFR31.18769690
41MAP3K21.18681882
42TAOK11.17926159
43WEE11.15749817
44WNK41.13207678
45FRK1.11397529
46JAK31.10661450
47CDK61.09079398
48INSRR1.08953643
49MAP3K61.07374222
50FGFR41.06921985
51SIK11.04438821
52CHUK1.04322014
53MST41.00153744
54PBK0.99178553
55FER0.97164027
56PAK40.91160947
57CHEK10.90562242
58CHEK20.89529593
59CDK80.89176987
60AKT30.88920510
61ERN10.87323191
62STK380.86833370
63SMG10.85889965
64PTK20.85461505
65ATM0.84005011
66SGK30.83366490
67BMX0.81787315
68ALK0.80869923
69JAK10.80309021
70TRPM70.79991022
71PRKD30.79215025
72TYRO30.78406826
73RPS6KA40.78166907
74SCYL20.77284192
75STK40.77121673
76EPHA30.75656484
77ATR0.74510517
78MKNK20.73760862
79AURKB0.73498780
80MAP3K30.73303746
81MARK30.73197389
82BRSK10.70144526
83FGFR20.70097895
84RET0.69775385
85TGFBR20.69562005
86CDK70.69374569
87PLK40.68435969
88ZAK0.67291572
89KSR20.66636114
90STK240.66282955
91PRKAA20.65314444
92DDR20.65196232
93PIM10.64566880
94CASK0.64528407
95PRKCI0.64411096
96PLK10.64296401
97OXSR10.62447877
98MAPKAPK30.61780197
99* CDK20.61709419
100MAP3K50.61674462
101MAP3K80.61591649
102ERBB40.61579504
103EPHB10.60980849
104ACVR1B0.59115509
105WNK10.58816821
106RPS6KB20.57432826
107MAP3K70.55805425
108PRKAA10.55081975
109FGFR10.54909926
110MAP3K10.54474713
111PAK20.53311358
112MARK20.53057462
113MAP2K10.52506109
114KSR10.50236191
115TLK10.49280737
116NLK0.48650812
117CDC42BPA0.47218831
118* MAPK140.47078407
119SGK20.46799608
120PDPK10.45914446
121ABL10.45887014
122PIK3CA0.45709047
123* CDK10.44857049
124MAPK10.42965865
125AKT20.41346423
126TYK20.41214114
127PINK10.40730893
128NEK90.40256254
129BRAF0.40204286
130CSNK1D0.39040927
131ERBB20.38895628
132AKT10.37966036
133JAK20.37878461
134RPS6KB10.37681294
135PRKD20.37651047
136PRKDC0.37183129
137RPS6KA20.36326339
138MAPK110.36188796
139NTRK10.32667693
140PTK2B0.32438062
141* MAPK100.31677572
142CAMK40.29204273
143TSSK60.28245113
144* GSK3B0.28111284

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.28310615
2Adherens junction_Homo sapiens_hsa045202.06015092
3Cell cycle_Homo sapiens_hsa041101.94402567
4MicroRNAs in cancer_Homo sapiens_hsa052061.93742128
5Small cell lung cancer_Homo sapiens_hsa052221.92388145
6Chronic myeloid leukemia_Homo sapiens_hsa052201.81753828
7mTOR signaling pathway_Homo sapiens_hsa041501.58674792
8Fatty acid biosynthesis_Homo sapiens_hsa000611.54165804
9Pancreatic cancer_Homo sapiens_hsa052121.53883569
10Dorso-ventral axis formation_Homo sapiens_hsa043201.51461582
11p53 signaling pathway_Homo sapiens_hsa041151.51453999
12TGF-beta signaling pathway_Homo sapiens_hsa043501.48249261
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41088823
14Endometrial cancer_Homo sapiens_hsa052131.38992206
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38092953
16Prostate cancer_Homo sapiens_hsa052151.36878298
17Proteoglycans in cancer_Homo sapiens_hsa052051.34825006
18RNA transport_Homo sapiens_hsa030131.33580854
19Focal adhesion_Homo sapiens_hsa045101.30404394
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.28226488
21Herpes simplex infection_Homo sapiens_hsa051681.27687445
22FoxO signaling pathway_Homo sapiens_hsa040681.27289253
23mRNA surveillance pathway_Homo sapiens_hsa030151.26799822
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26721720
25Prolactin signaling pathway_Homo sapiens_hsa049171.26402792
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24674351
27ECM-receptor interaction_Homo sapiens_hsa045121.24578504
28Toxoplasmosis_Homo sapiens_hsa051451.24253765
29Hippo signaling pathway_Homo sapiens_hsa043901.23302251
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19755806
31Notch signaling pathway_Homo sapiens_hsa043301.18092410
32Colorectal cancer_Homo sapiens_hsa052101.17027969
33Viral myocarditis_Homo sapiens_hsa054161.16736396
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16082508
35Acute myeloid leukemia_Homo sapiens_hsa052211.15363873
36Insulin resistance_Homo sapiens_hsa049311.12245850
37HTLV-I infection_Homo sapiens_hsa051661.11010324
38TNF signaling pathway_Homo sapiens_hsa046681.10930997
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10660905
40Hepatitis B_Homo sapiens_hsa051611.10148433
41Non-small cell lung cancer_Homo sapiens_hsa052231.09963377
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09337086
43Fanconi anemia pathway_Homo sapiens_hsa034601.08144934
44Type II diabetes mellitus_Homo sapiens_hsa049301.05516422
45Viral carcinogenesis_Homo sapiens_hsa052031.04687099
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.04073396
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02498296
48Influenza A_Homo sapiens_hsa051640.99744864
49Osteoclast differentiation_Homo sapiens_hsa043800.99244110
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98609920
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98493176
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98323582
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96229411
54Non-homologous end-joining_Homo sapiens_hsa034500.96124327
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94514235
56Leishmaniasis_Homo sapiens_hsa051400.93706247
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92699290
58Bladder cancer_Homo sapiens_hsa052190.92437612
59Amoebiasis_Homo sapiens_hsa051460.91973158
60Basal cell carcinoma_Homo sapiens_hsa052170.91907265
61GnRH signaling pathway_Homo sapiens_hsa049120.91661932
62Renal cell carcinoma_Homo sapiens_hsa052110.91528305
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.91473858
64Gap junction_Homo sapiens_hsa045400.90928614
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.90650732
66Thyroid cancer_Homo sapiens_hsa052160.90175630
67Basal transcription factors_Homo sapiens_hsa030220.90105124
68Measles_Homo sapiens_hsa051620.89927867
69RNA degradation_Homo sapiens_hsa030180.88729091
70Ovarian steroidogenesis_Homo sapiens_hsa049130.87041497
71Other glycan degradation_Homo sapiens_hsa005110.86507868
72Pathways in cancer_Homo sapiens_hsa052000.86453225
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85878197
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84233957
75Melanoma_Homo sapiens_hsa052180.83846325
76Glioma_Homo sapiens_hsa052140.80855178
77Apoptosis_Homo sapiens_hsa042100.80578112
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80144069
79Circadian rhythm_Homo sapiens_hsa047100.79534447
80AMPK signaling pathway_Homo sapiens_hsa041520.79476651
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77930991
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.77740302
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77100841
84Dilated cardiomyopathy_Homo sapiens_hsa054140.76530915
85Sphingolipid metabolism_Homo sapiens_hsa006000.75947254
86Melanogenesis_Homo sapiens_hsa049160.75600981
87Choline metabolism in cancer_Homo sapiens_hsa052310.74989121
88Endocytosis_Homo sapiens_hsa041440.74445855
89Platelet activation_Homo sapiens_hsa046110.74265355
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71974847
91Long-term potentiation_Homo sapiens_hsa047200.71970541
92Thyroid hormone synthesis_Homo sapiens_hsa049180.71648282
93B cell receptor signaling pathway_Homo sapiens_hsa046620.70644868
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70483004
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.68021015
96Glucagon signaling pathway_Homo sapiens_hsa049220.67537068
97Inositol phosphate metabolism_Homo sapiens_hsa005620.67395376
98Insulin signaling pathway_Homo sapiens_hsa049100.65925678
99ErbB signaling pathway_Homo sapiens_hsa040120.64939387
100Tight junction_Homo sapiens_hsa045300.63345074
101HIF-1 signaling pathway_Homo sapiens_hsa040660.62787160
102Oocyte meiosis_Homo sapiens_hsa041140.62467948
103VEGF signaling pathway_Homo sapiens_hsa043700.61928557
104Wnt signaling pathway_Homo sapiens_hsa043100.61733224
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.61376244
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61257598
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60511385
108T cell receptor signaling pathway_Homo sapiens_hsa046600.59546884
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59308989
110Epstein-Barr virus infection_Homo sapiens_hsa051690.58975252
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.58848811
112Axon guidance_Homo sapiens_hsa043600.57781882
113Hepatitis C_Homo sapiens_hsa051600.57750255
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.57237912
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56576954
116Estrogen signaling pathway_Homo sapiens_hsa049150.56373906
117One carbon pool by folate_Homo sapiens_hsa006700.55902926
118Prion diseases_Homo sapiens_hsa050200.55822256
119ABC transporters_Homo sapiens_hsa020100.55808762
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55273110
121MAPK signaling pathway_Homo sapiens_hsa040100.55100874
122Antigen processing and presentation_Homo sapiens_hsa046120.55065478
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53884992
124Rap1 signaling pathway_Homo sapiens_hsa040150.53799498
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52628678
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51536258
127Bile secretion_Homo sapiens_hsa049760.50886902
128Lysosome_Homo sapiens_hsa041420.50614831
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48037375

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