PPFIBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.02978708
2cell adhesion mediated by integrin (GO:0033627)4.88186280
3chondrocyte proliferation (GO:0035988)4.40384343
4protein heterotrimerization (GO:0070208)4.34619418
5endodermal cell differentiation (GO:0035987)4.09710251
6plasma membrane repair (GO:0001778)4.00054186
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.90959252
8retina vasculature morphogenesis in camera-type eye (GO:0061299)3.82387820
9vascular endothelial growth factor signaling pathway (GO:0038084)3.81192952
10basement membrane organization (GO:0071711)3.71547410
11bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67002801
12apoptotic cell clearance (GO:0043277)3.65258527
13wound healing, spreading of epidermal cells (GO:0035313)3.63175708
14sarcomere organization (GO:0045214)3.58670890
15desmosome organization (GO:0002934)3.54669239
16cardiac myofibril assembly (GO:0055003)3.53412786
17axon extension involved in axon guidance (GO:0048846)3.47780235
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.47780235
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.45790953
20dermatan sulfate biosynthetic process (GO:0030208)3.45311132
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.44610466
22endothelial cell morphogenesis (GO:0001886)3.39057855
23hippo signaling (GO:0035329)3.37959548
24skin morphogenesis (GO:0043589)3.37459540
25collagen metabolic process (GO:0032963)3.36595534
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35405813
27cellular response to vitamin (GO:0071295)3.32564064
28negative regulation of fatty acid transport (GO:2000192)3.29606377
29collagen catabolic process (GO:0030574)3.25751750
30cellular response to vitamin D (GO:0071305)3.19083831
31multicellular organismal macromolecule metabolic process (GO:0044259)3.18248226
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17269683
33sequestering of extracellular ligand from receptor (GO:0035581)3.15858706
34cell migration involved in sprouting angiogenesis (GO:0002042)3.15817839
35COPI coating of Golgi vesicle (GO:0048205)3.10641347
36Golgi transport vesicle coating (GO:0048200)3.10641347
37regulation of the force of heart contraction (GO:0002026)3.08767381
38positive regulation of p38MAPK cascade (GO:1900745)3.08713601
39endocardial cushion development (GO:0003197)3.08167310
40low-density lipoprotein particle clearance (GO:0034383)3.06289593
41epithelial cell-cell adhesion (GO:0090136)3.06218095
42multicellular organismal metabolic process (GO:0044236)3.04757468
43dermatan sulfate metabolic process (GO:0030205)3.01503417
44regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.01488605
45cellular response to interferon-alpha (GO:0035457)3.01390198
46regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.00854947
47extracellular matrix disassembly (GO:0022617)3.00839060
48multicellular organismal catabolic process (GO:0044243)3.00562485
49positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00190782
50negative regulation of protein localization to cell surface (GO:2000009)2.99960342
51hemidesmosome assembly (GO:0031581)2.98349329
52insulin-like growth factor receptor signaling pathway (GO:0048009)2.94985686
53negative regulation of chondrocyte differentiation (GO:0032331)2.92732118
54regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92416880
55wound healing, spreading of cells (GO:0044319)2.89629024
56myofibril assembly (GO:0030239)2.89434709
57regulation of tight junction assembly (GO:2000810)2.89151111
58regulation of actin filament-based movement (GO:1903115)2.88703139
59renal filtration (GO:0097205)2.87020070
60keratan sulfate catabolic process (GO:0042340)2.86432660
61actin-myosin filament sliding (GO:0033275)2.85213972
62muscle filament sliding (GO:0030049)2.85213972
63regulation of integrin-mediated signaling pathway (GO:2001044)2.84178764
64regulation of SMAD protein import into nucleus (GO:0060390)2.84146136
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.83907349
66substrate adhesion-dependent cell spreading (GO:0034446)2.83633402
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83385947
68actomyosin structure organization (GO:0031032)2.83053634
69actin-mediated cell contraction (GO:0070252)2.82385958
70protein localization to cell surface (GO:0034394)2.80851999
71regulation of cardioblast differentiation (GO:0051890)2.80726819
72negative regulation of axon extension involved in axon guidance (GO:0048843)2.80187235
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.79238110
74negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78360749
75mesenchymal-epithelial cell signaling (GO:0060638)2.78180352
76lymph vessel development (GO:0001945)2.77020693
77glomerular basement membrane development (GO:0032836)2.76251242
78regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.76015587
79blood vessel endothelial cell migration (GO:0043534)2.75557162
80cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.75524105
81chondrocyte development (GO:0002063)2.74568224
82peptidyl-proline hydroxylation (GO:0019511)2.74108339
83cell-substrate junction assembly (GO:0007044)2.71151613
84regulation of axon extension involved in axon guidance (GO:0048841)2.70376219
85ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.70338016
86cell communication involved in cardiac conduction (GO:0086065)2.69871139
87positive regulation of osteoblast proliferation (GO:0033690)2.69396175
88protein hydroxylation (GO:0018126)2.68583287
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67308179
90bone trabecula formation (GO:0060346)2.65698978
91regulation of membrane protein ectodomain proteolysis (GO:0051043)2.65470609
92glomerular filtration (GO:0003094)2.63514135
93stress fiber assembly (GO:0043149)2.63342081
94cardiac muscle tissue morphogenesis (GO:0055008)2.61936213
95smooth muscle tissue development (GO:0048745)2.61833556
96cardiac muscle cell development (GO:0055013)2.61439318
97lymphangiogenesis (GO:0001946)2.61401854
98positive regulation of epithelial to mesenchymal transition (GO:0010718)2.60931704
99regulation of cell communication by electrical coupling (GO:0010649)2.59244299
100blood vessel maturation (GO:0001955)2.58079649
101mesodermal cell differentiation (GO:0048333)2.56762149
102regulation of heart morphogenesis (GO:2000826)2.56315334
103gap junction assembly (GO:0016264)2.55883982
104cardiac muscle contraction (GO:0060048)2.55790232
105maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55045616
106glomerular visceral epithelial cell development (GO:0072015)2.54690753
107positive regulation of SMAD protein import into nucleus (GO:0060391)2.54586418
108negative regulation of catenin import into nucleus (GO:0035414)2.53872015
109pericardium development (GO:0060039)2.53326554
110regulation of transforming growth factor beta2 production (GO:0032909)2.53174265
111substrate-dependent cell migration (GO:0006929)2.52553717
112cardiac cell development (GO:0055006)2.52205456
113cell communication by electrical coupling (GO:0010644)2.51322312
114ventricular cardiac muscle cell action potential (GO:0086005)2.50912621
115fibroblast migration (GO:0010761)2.50125919
116negative regulation of cartilage development (GO:0061037)2.49692270
117metanephric mesenchyme development (GO:0072075)2.49355409
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.49017768
119coronary vasculature morphogenesis (GO:0060977)2.48201146
120muscle tissue morphogenesis (GO:0060415)2.47996310
121extracellular matrix organization (GO:0030198)2.47533368
122vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46831108
123growth hormone receptor signaling pathway (GO:0060396)2.46734062
124extracellular structure organization (GO:0043062)2.46684904
125branching involved in salivary gland morphogenesis (GO:0060445)2.46232554
126sprouting angiogenesis (GO:0002040)2.45772753
127glycoprotein catabolic process (GO:0006516)2.45050218
128adherens junction assembly (GO:0034333)2.45047768
129germ cell migration (GO:0008354)2.44620589
130cell migration involved in heart development (GO:0060973)2.44365478
131regulation of cardiac muscle cell contraction (GO:0086004)2.41938654
132epoxygenase P450 pathway (GO:0019373)2.41598892
133positive regulation of cartilage development (GO:0061036)2.40216644
134positive regulation of extracellular matrix organization (GO:1903055)2.40067981
135polarized epithelial cell differentiation (GO:0030859)2.39774199
136iron ion import (GO:0097286)2.38667108
137tooth mineralization (GO:0034505)2.38327827
138craniofacial suture morphogenesis (GO:0097094)2.37266228
139regulation of p38MAPK cascade (GO:1900744)2.36092501
140positive regulation of heart rate (GO:0010460)2.36015649
141regulation of axon guidance (GO:1902667)2.35532084
142positive regulation of hormone biosynthetic process (GO:0046886)2.35026066
143keratinocyte proliferation (GO:0043616)2.33700400
144embryonic heart tube development (GO:0035050)2.30776187
145paraxial mesoderm development (GO:0048339)2.29996802
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.29939577
147kidney mesenchyme development (GO:0072074)2.29064649
148glomerular epithelial cell development (GO:0072310)2.28538355
149actin filament-based movement (GO:0030048)2.28050865
150negative regulation of potassium ion transmembrane transport (GO:1901380)2.26287448
151regulation of hippo signaling (GO:0035330)2.25392875
152regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.25233340
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.24749882
154negative regulation of axon guidance (GO:1902668)2.24553388
155regulation of sarcomere organization (GO:0060297)2.18951362
156positive regulation of cardiac muscle cell differentiation (GO:2000727)2.18467989
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.18064878
158regulation of striated muscle contraction (GO:0006942)2.17142441
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.16704133
160artery development (GO:0060840)2.15879333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.44743058
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.41019711
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.94757430
4CLOCK_20551151_ChIP-Seq_293T_Human3.64879649
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.54314162
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21033268
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50266161
8CJUN_26792858_Chip-Seq_BT549_Human2.48212921
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.46531296
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.45558194
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.43480133
12* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.43392867
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42619437
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.41268310
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.40684787
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37808907
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36919037
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.35824598
19* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.34888364
20* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32007844
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.27090047
22* BRD4_25478319_ChIP-Seq_HGPS_Human2.15662498
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11675391
24PPAR_26484153_Chip-Seq_NCI-H1993_Human2.11259817
25GBX2_23144817_ChIP-Seq_PC3_Human2.09447796
26EP300_21415370_ChIP-Seq_HL-1_Mouse2.07664694
27NRF2_20460467_ChIP-Seq_MEFs_Mouse2.04534961
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.04534961
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04260962
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04260962
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99796268
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.98378373
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.98006516
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.94444832
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84803512
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81907190
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80138997
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77914446
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.76171837
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.70615876
41SOX2_20726797_ChIP-Seq_SW620_Human1.67090714
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66250148
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65518545
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63908245
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63425958
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.63208439
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62828549
48* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58072749
49* LXR_22158963_ChIP-Seq_LIVER_Mouse1.55912029
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54797446
51UBF1/2_26484160_Chip-Seq_HMECs_Human1.52514622
52SMAD4_21799915_ChIP-Seq_A2780_Human1.52441218
53* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52160086
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51341851
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.51097740
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.51097740
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50139817
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49882392
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48626371
60* TP53_16413492_ChIP-PET_HCT116_Human1.44738280
61* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44137024
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.43827217
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42270772
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42033264
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40923884
66ATF3_27146783_Chip-Seq_COLON_Human1.40330375
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39931208
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38053122
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37137682
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36691252
71* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36221759
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.35891763
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.34036023
74* TP53_18474530_ChIP-ChIP_U2OS_Human1.33613277
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31676587
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.31498287
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.30473252
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29910618
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.29165835
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28584917
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27840988
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.27631836
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26515258
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.25623108
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24725882
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24385366
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23401946
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22964586
89PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21529311
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20897797
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20212210
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20133559
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19596250
94* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.19332316
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18828273
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18720295
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17239448
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17239448
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17057643
100* STAT3_23295773_ChIP-Seq_U87_Human1.16279987
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15868167
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.15114386
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14372986
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.13865848
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13698405
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.13611302
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11633762
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11613681
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10461212
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10229977
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10212308
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10094415
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09387530
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08413551
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04479102
116* TP63_23658742_ChIP-Seq_EP156T_Human1.04362081
117P300_19829295_ChIP-Seq_ESCs_Human1.03740257
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02996066
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02149439
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01743290
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00852756
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00493947
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00455973
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.00302162
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99067642
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98726224
127* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97859616
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97239681
129GATA4_25053715_ChIP-Seq_YYC3_Human0.96955209
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.96726310
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.96632044
132AR_21572438_ChIP-Seq_LNCaP_Human0.96592534
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.95730327
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95040244
135SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94363658
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93668690
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93521587
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.93517939
139RACK7_27058665_Chip-Seq_MCF-7_Human0.92345060
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87224206
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86994106
142AHR_22903824_ChIP-Seq_MCF-7_Human0.86562647
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85868126
144GATA1_22025678_ChIP-Seq_K562_Human0.85623788
145RXR_22108803_ChIP-Seq_LS180_Human0.84919336
146TP53_22127205_ChIP-Seq_IMR90_Human0.83888846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.41656730
2MP0005275_abnormal_skin_tensile4.32769005
3MP0003705_abnormal_hypodermis_morpholog4.24671366
4MP0005503_abnormal_tendon_morphology3.72243391
5MP0004272_abnormal_basement_membrane3.28577005
6MP0005623_abnormal_meninges_morphology2.64466418
7MP0003279_aneurysm2.60216899
8MP0001958_emphysema2.44512964
9MP0003566_abnormal_cell_adhesion2.38855518
10MP0004036_abnormal_muscle_relaxation2.30274755
11MP0004215_abnormal_myocardial_fiber2.30083427
12MP0009384_cardiac_valve_regurgitation2.29145268
13MP0010352_gastrointestinal_tract_polyps2.20093116
14MP0005257_abnormal_intraocular_pressure2.04443868
15MP0002877_abnormal_melanocyte_morpholog2.00586707
16MP0002060_abnormal_skin_morphology1.86869545
17MP0005330_cardiomyopathy1.86196536
18MP0000733_abnormal_muscle_development1.80758356
19MP0003091_abnormal_cell_migration1.80685182
20MP0006054_spinal_hemorrhage1.78032538
21MP0010368_abnormal_lymphatic_system1.74243467
22MP0005023_abnormal_wound_healing1.72557385
23MP0000013_abnormal_adipose_tissue1.59109233
24MP0005508_abnormal_skeleton_morphology1.55259917
25MP0004484_altered_response_of1.51818995
26MP0001879_abnormal_lymphatic_vessel1.51517105
27MP0002896_abnormal_bone_mineralization1.50587432
28MP0002108_abnormal_muscle_morphology1.48369327
29MP0010234_abnormal_vibrissa_follicle1.45957729
30MP0005076_abnormal_cell_differentiation1.43763934
31MP0005620_abnormal_muscle_contractility1.43549875
32MP0001299_abnormal_eye_distance/1.43467973
33MP0002295_abnormal_pulmonary_circulatio1.43207715
34MP0000767_abnormal_smooth_muscle1.40055014
35MP0005171_absent_coat_pigmentation1.39109192
36MP0003300_gastrointestinal_ulcer1.36254161
37MP0000750_abnormal_muscle_regeneration1.35694169
38MP0004185_abnormal_adipocyte_glucose1.30625643
39MP0003385_abnormal_body_wall1.30263105
40MP0000751_myopathy1.27164817
41MP0003941_abnormal_skin_development1.26443761
42MP0010030_abnormal_orbit_morphology1.24588101
43MP0009250_abnormal_appendicular_skeleto1.22264648
44MP0004084_abnormal_cardiac_muscle1.20833039
45MP0009053_abnormal_anal_canal1.18236962
46MP0002282_abnormal_trachea_morphology1.18122634
47MP0002168_other_aberrant_phenotype1.16793803
48MP0003045_fibrosis1.16556031
49MP0002269_muscular_atrophy1.16260563
50MP0005409_darkened_coat_color1.16113735
51MP0004233_abnormal_muscle_weight1.13631396
52MP0000163_abnormal_cartilage_morphology1.11322071
53MP0001243_abnormal_dermal_layer1.10898706
54MP0004085_abnormal_heartbeat1.08489950
55MP0005165_increased_susceptibility_to1.08215500
56MP0005595_abnormal_vascular_smooth1.06711747
57MP0000003_abnormal_adipose_tissue1.05763548
58MP0002115_abnormal_skeleton_extremities1.04007893
59MP0000569_abnormal_digit_pigmentation1.02719842
60MP0005187_abnormal_penis_morphology1.02171988
61MP0005670_abnormal_white_adipose1.01958791
62MP0004087_abnormal_muscle_fiber1.00247003
63MP0006138_congestive_heart_failure1.00036630
64MP0003283_abnormal_digestive_organ0.99680860
65MP0004510_myositis0.99513803
66MP0000516_abnormal_urinary_system0.99494496
67MP0005367_renal/urinary_system_phenotyp0.99494496
68MP0005666_abnormal_adipose_tissue0.99328584
69MP0005408_hypopigmentation0.98625783
70MP0001542_abnormal_bone_strength0.98288510
71MP0004134_abnormal_chest_morphology0.96071963
72MP0009780_abnormal_chondrocyte_physiolo0.95807507
73MP0005375_adipose_tissue_phenotype0.95742792
74MP0002128_abnormal_blood_circulation0.94915908
75MP0000579_abnormal_nail_morphology0.94569725
76MP0010630_abnormal_cardiac_muscle0.93111679
77MP0005369_muscle_phenotype0.90712381
78MP0002332_abnormal_exercise_endurance0.90350754
79MP0005390_skeleton_phenotype0.90267375
80MP0004858_abnormal_nervous_system0.90219048
81MP0003828_pulmonary_edema0.87967319
82MP0002113_abnormal_skeleton_development0.87638250
83MP0003252_abnormal_bile_duct0.87608908
84MP0001915_intracranial_hemorrhage0.86966402
85MP0003115_abnormal_respiratory_system0.86194099
86MP0002925_abnormal_cardiovascular_devel0.85211639
87MP0003137_abnormal_impulse_conducting0.84873595
88MP0001614_abnormal_blood_vessel0.84441665
89MP0000747_muscle_weakness0.83868518
90MP0002998_abnormal_bone_remodeling0.83165622
91MP0002127_abnormal_cardiovascular_syste0.83051122
92MP0002106_abnormal_muscle_physiology0.82750764
93MP0001661_extended_life_span0.81544294
94MP0000428_abnormal_craniofacial_morphol0.81427583
95MP0003942_abnormal_urinary_system0.80643266
96MP0010307_abnormal_tumor_latency0.80536793
97MP0002796_impaired_skin_barrier0.80489652
98MP0000432_abnormal_head_morphology0.80395276
99MP0003937_abnormal_limbs/digits/tail_de0.80280749
100MP0000749_muscle_degeneration0.80070100
101MP0008775_abnormal_heart_ventricle0.79785883
102MP0003935_abnormal_craniofacial_develop0.79330118
103MP0000534_abnormal_ureter_morphology0.78553494
104MP0004197_abnormal_fetal_growth/weight/0.77761584
105MP0002933_joint_inflammation0.77534962
106MP0005197_abnormal_uvea_morphology0.76850792
107MP0002697_abnormal_eye_size0.76561452
108MP0003453_abnormal_keratinocyte_physiol0.76142670
109MP0002837_dystrophic_cardiac_calcinosis0.76089094
110MP0000266_abnormal_heart_morphology0.75139778
111MP0002972_abnormal_cardiac_muscle0.74691527
112MP0003950_abnormal_plasma_membrane0.73867653
113MP0004130_abnormal_muscle_cell0.73379225
114MP0002234_abnormal_pharynx_morphology0.72874974
115MP0000537_abnormal_urethra_morphology0.72452294
116MP0000762_abnormal_tongue_morphology0.71879131
117MP0000759_abnormal_skeletal_muscle0.71740715
118MP0001533_abnormal_skeleton_physiology0.70658390
119MP0002932_abnormal_joint_morphology0.69854936
120MP0005248_abnormal_Harderian_gland0.69635842
121MP0003755_abnormal_palate_morphology0.69626349
122MP0005164_abnormal_response_to0.68768428
123MP0003448_altered_tumor_morphology0.68268603
124MP0003567_abnormal_fetal_cardiomyocyte0.68032426
125MP0005385_cardiovascular_system_phenoty0.67997346
126MP0001544_abnormal_cardiovascular_syste0.67997346
127MP0010678_abnormal_skin_adnexa0.66781877
128MP0000467_abnormal_esophagus_morphology0.66109486
129MP0000427_abnormal_hair_cycle0.61152618
130MP0002233_abnormal_nose_morphology0.59291305

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.16938696
2Protrusio acetabuli (HP:0003179)6.13475429
3Ankle contracture (HP:0006466)4.19385294
4Cervical subluxation (HP:0003308)4.14601243
5Aortic dissection (HP:0002647)3.80433948
6Increased connective tissue (HP:0009025)3.70029628
7Sudden death (HP:0001699)3.65432920
8Shallow orbits (HP:0000586)3.60106362
9Cerebral aneurysm (HP:0004944)3.55291590
10Aortic aneurysm (HP:0004942)3.53389536
11Atrophic scars (HP:0001075)3.52439613
12Bundle branch block (HP:0011710)3.46041231
13Peritonitis (HP:0002586)3.38174006
14Type 1 muscle fiber predominance (HP:0003803)3.37175645
15Soft skin (HP:0000977)3.35723255
16Spinal rigidity (HP:0003306)3.22114258
17Ventricular tachycardia (HP:0004756)3.19712491
18Atrial fibrillation (HP:0005110)3.10822039
19Broad metatarsal (HP:0001783)3.09337837
20Dilatation of the ascending aorta (HP:0005111)3.06891253
21Lipoatrophy (HP:0100578)2.92745588
22Mitral valve prolapse (HP:0001634)2.91944216
23Fragile skin (HP:0001030)2.91749695
24Neonatal short-limb short stature (HP:0008921)2.85448070
25Wormian bones (HP:0002645)2.83768798
26Bladder diverticulum (HP:0000015)2.79335461
27Abnormality of dentin (HP:0010299)2.75032524
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.72015786
29Osteolytic defects of the hand bones (HP:0009699)2.72015786
30Blue sclerae (HP:0000592)2.71185759
31Primary atrial arrhythmia (HP:0001692)2.69501480
32Follicular hyperkeratosis (HP:0007502)2.63400964
33Aneurysm (HP:0002617)2.59878096
34Abnormality of the calf musculature (HP:0001430)2.59207596
35Right ventricular cardiomyopathy (HP:0011663)2.58744511
36Supraventricular arrhythmia (HP:0005115)2.58508740
37Genu recurvatum (HP:0002816)2.58214618
38Vascular tortuosity (HP:0004948)2.57053845
39Supraventricular tachycardia (HP:0004755)2.55869618
40Scapular winging (HP:0003691)2.55752785
41Hypoplastic ischia (HP:0003175)2.53354922
42Mildly elevated creatine phosphokinase (HP:0008180)2.48624829
43Wrist flexion contracture (HP:0001239)2.48022896
44Difficulty climbing stairs (HP:0003551)2.44062031
45Cupped ribs (HP:0000887)2.42588366
46Overgrowth (HP:0001548)2.42160232
47Subacute progressive viral hepatitis (HP:0006572)2.40015145
48Arterial tortuosity (HP:0005116)2.39835729
49Vertebral compression fractures (HP:0002953)2.35311020
50Abnormality of the acetabulum (HP:0003170)2.31283143
51Distal lower limb muscle weakness (HP:0009053)2.29479707
52Short nail (HP:0001799)2.28537795
53Abnormal atrioventricular conduction (HP:0005150)2.24818712
54Hyporeflexia of lower limbs (HP:0002600)2.22774350
55Abnormality of the ischium (HP:0003174)2.22612127
56Muscle fiber splitting (HP:0003555)2.20101473
57Ulnar bowing (HP:0003031)2.18642343
58Natal tooth (HP:0000695)2.17746493
59Thin bony cortex (HP:0002753)2.16957658
60Increased variability in muscle fiber diameter (HP:0003557)2.16780855
61Hyperextensible skin (HP:0000974)2.15177309
62Upper limb amyotrophy (HP:0009129)2.14255219
63Distal upper limb amyotrophy (HP:0007149)2.14255219
64Hematochezia (HP:0002573)2.14165219
65Elbow flexion contracture (HP:0002987)2.13949328
66Exostoses (HP:0100777)2.12514595
67Lymphangioma (HP:0100764)2.11886594
68Syncope (HP:0001279)2.11808910
69Round ear (HP:0100830)2.09197623
70Radial bowing (HP:0002986)2.07763899
71Abnormal delivery (HP:0001787)2.06806839
72Epiphyseal dysplasia (HP:0002656)2.05729974
73Limited hip movement (HP:0008800)2.03362426
74Tibial bowing (HP:0002982)2.03316582
75Slender build (HP:0001533)2.02371095
76Bradycardia (HP:0001662)2.01708979
77Knee flexion contracture (HP:0006380)2.00594437
78Mitral stenosis (HP:0001718)1.98530113
79Myocardial infarction (HP:0001658)1.98343093
80Camptodactyly of toe (HP:0001836)1.98108153
81Heart block (HP:0012722)1.97983578
82Biconcave vertebral bodies (HP:0004586)1.97982744
83Ventricular arrhythmia (HP:0004308)1.97547622
84Abnormality of skeletal muscle fiber size (HP:0012084)1.97277141
85Dilated cardiomyopathy (HP:0001644)1.96616783
86Increased density of long bones (HP:0006392)1.96083535
87Platyspondyly (HP:0000926)1.96019934
88Hypoplasia of the iris (HP:0007676)1.96012022
89Osteoarthritis (HP:0002758)1.95756063
90Broad ribs (HP:0000885)1.95143637
91Mesomelia (HP:0003027)1.94786480
92Joint laxity (HP:0001388)1.93647621
93Hip contracture (HP:0003273)1.93119866
94Abnormality of the calcaneus (HP:0008364)1.91329768
95Atrioventricular block (HP:0001678)1.90610044
96Bell-shaped thorax (HP:0001591)1.89283734
97Reduced subcutaneous adipose tissue (HP:0003758)1.88382474
98Spondylolisthesis (HP:0003302)1.87310425
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87102203
100Cardiovascular calcification (HP:0011915)1.86741939
101Flat acetabular roof (HP:0003180)1.86332055
102Asymmetric septal hypertrophy (HP:0001670)1.85917682
103Ectopia lentis (HP:0001083)1.85542199
104Ulnar deviation of the wrist (HP:0003049)1.84683027
105Abnormality of the peritoneum (HP:0002585)1.84581430
106Metaphyseal cupping (HP:0003021)1.83191676
107Spinal cord lesions (HP:0100561)1.82643313
108Syringomyelia (HP:0003396)1.82643313
109Coxa vara (HP:0002812)1.82154076
110Abnormal auditory evoked potentials (HP:0006958)1.80952520
111Distal lower limb amyotrophy (HP:0008944)1.80263348
112Hand muscle atrophy (HP:0009130)1.79540371
113Wide anterior fontanel (HP:0000260)1.79185676
114Venous abnormality (HP:0002624)1.78692078
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78592055
116Aplasia involving bones of the upper limbs (HP:0009823)1.76990042
117Aplasia of the phalanges of the hand (HP:0009802)1.76990042
118Aplasia involving bones of the extremities (HP:0009825)1.76990042
119Striae distensae (HP:0001065)1.75279191
120Femoral bowing (HP:0002980)1.72947447
121Ovoid vertebral bodies (HP:0003300)1.72220348
122Deviation of the hallux (HP:0010051)1.71853536
123Bowel diverticulosis (HP:0005222)1.71654497
124Bowed forearm bones (HP:0003956)1.71035708
125Bowing of the arm (HP:0006488)1.71035708
126Infantile muscular hypotonia (HP:0008947)1.69671804
127Buphthalmos (HP:0000557)1.69471615
128Vertebral arch anomaly (HP:0008438)1.69332003
129Absent frontal sinuses (HP:0002688)1.68603009
130Metaphyseal dysplasia (HP:0100255)1.67062466
131Advanced eruption of teeth (HP:0006288)1.61177997
132Protruding ear (HP:0000411)1.59104009
133Pterygium (HP:0001059)1.58768863
134Limb-girdle muscle atrophy (HP:0003797)1.57224593
135EMG: myopathic abnormalities (HP:0003458)1.57115653
136Lower limb amyotrophy (HP:0007210)1.55898824
137Neck muscle weakness (HP:0000467)1.53882923
138Renal duplication (HP:0000075)1.52882218
139Aortic regurgitation (HP:0001659)1.52829495
140Palpitations (HP:0001962)1.49390599
141Mild short stature (HP:0003502)1.47617457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.05406259
2DDR23.71209670
3LATS13.68566981
4TRIB33.60247328
5PDGFRA3.01728619
6PKN22.59184357
7SIK12.40928746
8LMTK22.34479558
9FRK2.21956868
10AKT32.17282169
11RIPK12.15614054
12LATS22.05618882
13NEK92.02082859
14TRPM71.99868443
15PTK61.99374419
16NTRK11.85964887
17MAP3K31.83372093
18MST1R1.82440869
19ERN11.80290572
20FER1.77123201
21STK31.72885810
22PTK21.64117010
23MET1.61382965
24EPHA21.60420513
25EPHB21.55491907
26PAK21.53757381
27STK38L1.53395546
28BMX1.46230408
29PDGFRB1.44677503
30STK391.40494963
31TGFBR21.40135390
32LRRK21.36015173
33DMPK1.34184375
34CAMK1D1.33257047
35PAK31.27796532
36PAK41.23236530
37BCR1.19373259
38MARK11.18882570
39ERBB31.13980694
40SCYL21.13945544
41MUSK1.12246217
42MTOR1.11486294
43PIK3CA1.10521621
44PHKG11.09137921
45PHKG21.09137921
46TESK11.05733216
47MOS1.05070291
48BMPR1B1.04397461
49CDK61.03832055
50FGFR11.02115869
51KDR1.00909372
52RPS6KA40.99839870
53ROCK20.99173134
54NUAK10.98586162
55MAP3K120.98151273
56EPHA30.96905938
57EPHB10.96238374
58TGFBR10.95044496
59TIE10.93854176
60PIK3CG0.93637961
61PRKCE0.93409620
62PNCK0.92591156
63PTK2B0.91085597
64ROCK10.90781816
65MAP3K60.85527943
66CDC42BPA0.84427666
67MAP2K10.84361386
68CAMK2D0.84263148
69FGFR40.83908565
70MAP2K30.82001621
71CAMK1G0.81918578
72PDK20.81783592
73FLT30.79707065
74PAK60.79258674
75FGFR30.79208450
76STK380.78904819
77MAPKAPK50.78757021
78LIMK10.74921430
79JAK10.74476482
80FGFR20.71463087
81NEK10.70959960
82RET0.70400231
83MELK0.70156467
84CDK120.70000757
85EEF2K0.68238386
86STK100.65487633
87PRKG20.65315377
88CASK0.64981671
89GSK3A0.64159077
90INSR0.63378337
91ERBB40.63269895
92TYRO30.62951347
93ILK0.61864433
94PRKD30.61062657
95MAP3K100.59968891
96MAP3K20.59386470
97CAMK2A0.56538372
98INSRR0.55810566
99PBK0.54954161
100ADRBK10.54151621
101CDK80.52346616
102TRIM280.51775402
103PRKD10.51627259
104MAPKAPK30.50892281
105ABL20.50066876
106WNK10.48877254
107CAMK2B0.48859391
108DYRK1B0.48847889
109DAPK30.47884405
110EIF2AK30.47573952
111OBSCN0.47215443
112PLK20.47175847
113CSK0.47087504
114TBK10.46894999
115CHUK0.46580265
116ICK0.46298733
117AKT20.46181888
118MARK30.45855196
119ERBB20.45813029
120IGF1R0.45556852
121MYLK0.43232961
122TNIK0.42643675
123WNK40.42425804
124MAP3K70.42006706
125PDK40.40767748
126PDK30.40767748
127EPHA40.40671982
128CAMK2G0.38004129
129ABL10.37040998
130SRC0.36958642
131CSNK1A1L0.36584377
132JAK30.35207554
133PRKAA20.34969210
134STK240.34125149
135MAP3K80.33965621
136EGFR0.32953362
137PRKD20.32029423
138PRKCH0.31352146
139RPS6KA20.30979888
140MAP3K50.30828167
141ZAK0.30709533

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.79395692
2Focal adhesion_Homo sapiens_hsa045102.93814453
3Adherens junction_Homo sapiens_hsa045202.63128175
4Proteoglycans in cancer_Homo sapiens_hsa052052.24020255
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22182653
6Small cell lung cancer_Homo sapiens_hsa052222.05922591
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.99994179
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94374904
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91935263
10Amoebiasis_Homo sapiens_hsa051461.89481987
11Protein digestion and absorption_Homo sapiens_hsa049741.86159684
12TGF-beta signaling pathway_Homo sapiens_hsa043501.83621759
13Dilated cardiomyopathy_Homo sapiens_hsa054141.77336775
14MicroRNAs in cancer_Homo sapiens_hsa052061.67317216
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67104031
16Bladder cancer_Homo sapiens_hsa052191.63679830
17Malaria_Homo sapiens_hsa051441.61182297
18Viral myocarditis_Homo sapiens_hsa054161.60912400
19Hippo signaling pathway_Homo sapiens_hsa043901.51997939
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45925224
21Circadian rhythm_Homo sapiens_hsa047101.41333629
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37166588
23Chronic myeloid leukemia_Homo sapiens_hsa052201.34036103
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.30547073
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.30360225
26Tight junction_Homo sapiens_hsa045301.25092845
27Melanoma_Homo sapiens_hsa052181.20903955
28Basal cell carcinoma_Homo sapiens_hsa052171.18340514
29PPAR signaling pathway_Homo sapiens_hsa033201.17825423
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17576834
31Complement and coagulation cascades_Homo sapiens_hsa046101.17136705
32Insulin resistance_Homo sapiens_hsa049311.13984980
33Cardiac muscle contraction_Homo sapiens_hsa042601.12562579
34Renin secretion_Homo sapiens_hsa049241.12213225
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.12193000
36Prostate cancer_Homo sapiens_hsa052151.12019821
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11987327
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11358952
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.11267499
40Toxoplasmosis_Homo sapiens_hsa051451.10162395
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06286540
42Melanogenesis_Homo sapiens_hsa049161.03487003
43Fatty acid degradation_Homo sapiens_hsa000711.02223010
44Pancreatic cancer_Homo sapiens_hsa052121.01552537
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00992630
46TNF signaling pathway_Homo sapiens_hsa046680.99468373
47Nitrogen metabolism_Homo sapiens_hsa009100.98326177
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98315504
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93900584
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93545778
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90651649
52Hedgehog signaling pathway_Homo sapiens_hsa043400.89195300
53Caffeine metabolism_Homo sapiens_hsa002320.88565202
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.88493830
55p53 signaling pathway_Homo sapiens_hsa041150.87261058
56Renal cell carcinoma_Homo sapiens_hsa052110.85538078
57Calcium signaling pathway_Homo sapiens_hsa040200.85125338
58Shigellosis_Homo sapiens_hsa051310.84883545
59Oxytocin signaling pathway_Homo sapiens_hsa049210.83922831
60Pathways in cancer_Homo sapiens_hsa052000.83798371
61Glioma_Homo sapiens_hsa052140.83785163
62Gap junction_Homo sapiens_hsa045400.83280849
63Platelet activation_Homo sapiens_hsa046110.82702477
64HIF-1 signaling pathway_Homo sapiens_hsa040660.81326654
65Salivary secretion_Homo sapiens_hsa049700.81283909
66Insulin secretion_Homo sapiens_hsa049110.80041702
67Gastric acid secretion_Homo sapiens_hsa049710.80021001
68AMPK signaling pathway_Homo sapiens_hsa041520.79598540
69Lysine degradation_Homo sapiens_hsa003100.78980734
70Circadian entrainment_Homo sapiens_hsa047130.77668690
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77173917
72mTOR signaling pathway_Homo sapiens_hsa041500.76430456
73cAMP signaling pathway_Homo sapiens_hsa040240.76244262
74Starch and sucrose metabolism_Homo sapiens_hsa005000.75477904
75Phagosome_Homo sapiens_hsa041450.74538420
76Rap1 signaling pathway_Homo sapiens_hsa040150.74468730
77Fatty acid metabolism_Homo sapiens_hsa012120.73898996
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73175703
79Endometrial cancer_Homo sapiens_hsa052130.72594542
80Sulfur metabolism_Homo sapiens_hsa009200.72361976
81Apoptosis_Homo sapiens_hsa042100.71964853
82Legionellosis_Homo sapiens_hsa051340.69999172
83FoxO signaling pathway_Homo sapiens_hsa040680.69639768
84Glutamatergic synapse_Homo sapiens_hsa047240.69052727
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68636996
86Ras signaling pathway_Homo sapiens_hsa040140.65715147
87Salmonella infection_Homo sapiens_hsa051320.65581607
88Arginine and proline metabolism_Homo sapiens_hsa003300.65361762
89Pancreatic secretion_Homo sapiens_hsa049720.64914971
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63938164
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63078793
92HTLV-I infection_Homo sapiens_hsa051660.62450535
93Estrogen signaling pathway_Homo sapiens_hsa049150.60442765
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.60359999
95Dorso-ventral axis formation_Homo sapiens_hsa043200.60136428
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58947525
97Lysosome_Homo sapiens_hsa041420.58021272
98Insulin signaling pathway_Homo sapiens_hsa049100.56869749
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55226284
100GnRH signaling pathway_Homo sapiens_hsa049120.55179219
101Morphine addiction_Homo sapiens_hsa050320.55134898
102Ovarian steroidogenesis_Homo sapiens_hsa049130.55120495
103Cocaine addiction_Homo sapiens_hsa050300.55032784
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54184581
105Hepatitis B_Homo sapiens_hsa051610.54140346
106Selenocompound metabolism_Homo sapiens_hsa004500.53122725
107Leishmaniasis_Homo sapiens_hsa051400.52999179
108Arginine biosynthesis_Homo sapiens_hsa002200.52739067
109Prion diseases_Homo sapiens_hsa050200.52500606
110Dopaminergic synapse_Homo sapiens_hsa047280.51629822
111Colorectal cancer_Homo sapiens_hsa052100.51561808
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51474188
113GABAergic synapse_Homo sapiens_hsa047270.51342958
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51298015
115Pertussis_Homo sapiens_hsa051330.51184423
116Viral carcinogenesis_Homo sapiens_hsa052030.50318468
117Thyroid cancer_Homo sapiens_hsa052160.50211839
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50095912
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48834432
120Tryptophan metabolism_Homo sapiens_hsa003800.48336164
121Bile secretion_Homo sapiens_hsa049760.48027930
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47888950
123ABC transporters_Homo sapiens_hsa020100.47610368
124Osteoclast differentiation_Homo sapiens_hsa043800.47432957
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45694656
126Staphylococcus aureus infection_Homo sapiens_hsa051500.45583693
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44956230
128Axon guidance_Homo sapiens_hsa043600.44908230
129ErbB signaling pathway_Homo sapiens_hsa040120.44409699
130Tyrosine metabolism_Homo sapiens_hsa003500.44374136
131Propanoate metabolism_Homo sapiens_hsa006400.43671340
132Glucagon signaling pathway_Homo sapiens_hsa049220.42956542
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42179140
134Wnt signaling pathway_Homo sapiens_hsa043100.42107224
135Taste transduction_Homo sapiens_hsa047420.41544978
136Prolactin signaling pathway_Homo sapiens_hsa049170.40499538
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.40142452
138Cholinergic synapse_Homo sapiens_hsa047250.39525405
139Thyroid hormone synthesis_Homo sapiens_hsa049180.38660760
140Serotonergic synapse_Homo sapiens_hsa047260.36964462

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