PPFIBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.99626110
2axon ensheathment in central nervous system (GO:0032291)4.99626110
3L-phenylalanine catabolic process (GO:0006559)4.42803428
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.42803428
5regulation of activation of Janus kinase activity (GO:0010533)4.17328593
6fatty acid elongation (GO:0030497)4.16836939
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97958042
8L-phenylalanine metabolic process (GO:0006558)3.97958042
9neutrophil activation involved in immune response (GO:0002283)3.88527685
10negative regulation of cholesterol transport (GO:0032375)3.66020548
11negative regulation of sterol transport (GO:0032372)3.66020548
12aromatic amino acid family catabolic process (GO:0009074)3.61037549
13creatine metabolic process (GO:0006600)3.49536038
14positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.48235761
15plasma lipoprotein particle assembly (GO:0034377)3.44796258
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.43143572
17T-helper 1 type immune response (GO:0042088)3.40295895
18plasma lipoprotein particle clearance (GO:0034381)3.36167563
19protein-lipid complex assembly (GO:0065005)3.33518432
20heme transport (GO:0015886)3.25696703
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.16696072
22detection of other organism (GO:0098543)3.12135086
23regulation of cytokine secretion involved in immune response (GO:0002739)3.10929669
24detection of bacterium (GO:0016045)3.09278687
25regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.04896391
26tryptophan metabolic process (GO:0006568)3.04762916
27cholesterol biosynthetic process (GO:0006695)3.02249628
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00316717
29aromatic amino acid family metabolic process (GO:0009072)2.99441753
30tyrosine metabolic process (GO:0006570)2.97434524
31high-density lipoprotein particle remodeling (GO:0034375)2.96399640
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95284851
33adhesion of symbiont to host cell (GO:0044650)2.94090627
34virion attachment to host cell (GO:0019062)2.94090627
35indole-containing compound catabolic process (GO:0042436)2.90674642
36indolalkylamine catabolic process (GO:0046218)2.90674642
37tryptophan catabolic process (GO:0006569)2.90674642
38positive regulation of interleukin-17 production (GO:0032740)2.88323729
39low-density lipoprotein particle clearance (GO:0034383)2.87022679
40bile acid biosynthetic process (GO:0006699)2.84990696
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84155345
42reverse cholesterol transport (GO:0043691)2.81535683
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79533024
44very-low-density lipoprotein particle assembly (GO:0034379)2.79018350
45antigen processing and presentation of endogenous antigen (GO:0019883)2.78450348
46positive regulation of lipoprotein lipase activity (GO:0051006)2.77845757
47positive regulation of triglyceride lipase activity (GO:0061365)2.77845757
48regulation of triglyceride catabolic process (GO:0010896)2.77631138
49epoxygenase P450 pathway (GO:0019373)2.77374645
50axon ensheathment (GO:0008366)2.76371413
51ensheathment of neurons (GO:0007272)2.76371413
52striated muscle atrophy (GO:0014891)2.75898457
53alkaloid metabolic process (GO:0009820)2.75577297
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75113256
55kynurenine metabolic process (GO:0070189)2.74172256
56cellular response to thyroid hormone stimulus (GO:0097067)2.72046880
57protein carboxylation (GO:0018214)2.72018818
58peptidyl-glutamic acid carboxylation (GO:0017187)2.72018818
59macrophage activation involved in immune response (GO:0002281)2.70617624
60myelination (GO:0042552)2.70073555
61skeletal muscle adaptation (GO:0043501)2.69839732
62plasma lipoprotein particle remodeling (GO:0034369)2.69665809
63protein-lipid complex remodeling (GO:0034368)2.69665809
64macromolecular complex remodeling (GO:0034367)2.69665809
65cysteine metabolic process (GO:0006534)2.68121218
66complement activation, alternative pathway (GO:0006957)2.67704009
67sterol biosynthetic process (GO:0016126)2.67495770
68negative regulation of macroautophagy (GO:0016242)2.66449381
69glyoxylate metabolic process (GO:0046487)2.64835036
70serine family amino acid catabolic process (GO:0009071)2.64011423
71detection of external biotic stimulus (GO:0098581)2.63698367
72negative regulation of lipid storage (GO:0010888)2.62817104
73positive regulation of antigen processing and presentation (GO:0002579)2.62715873
74negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.61975303
75peptide catabolic process (GO:0043171)2.60555030
76plasma lipoprotein particle organization (GO:0071827)2.60155606
77regulation of cholesterol esterification (GO:0010872)2.59744594
78cholesterol efflux (GO:0033344)2.59590536
79fatty-acyl-CoA biosynthetic process (GO:0046949)2.59570948
80regulation of cholesterol homeostasis (GO:2000188)2.59415192
81protein-lipid complex subunit organization (GO:0071825)2.59133801
82phospholipid homeostasis (GO:0055091)2.59096554
83urea metabolic process (GO:0019627)2.58883601
84urea cycle (GO:0000050)2.58883601
85flavonoid metabolic process (GO:0009812)2.58866826
86complement activation, classical pathway (GO:0006958)2.58411583
87hydrogen peroxide biosynthetic process (GO:0050665)2.58360975
88regulation of protein activation cascade (GO:2000257)2.57558107
89regulation of superoxide anion generation (GO:0032928)2.57461463
90amine catabolic process (GO:0009310)2.56497986
91cellular biogenic amine catabolic process (GO:0042402)2.56497986
92alpha-linolenic acid metabolic process (GO:0036109)2.56487605
93low-density lipoprotein particle remodeling (GO:0034374)2.53765089
94long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.53596367
95cofactor catabolic process (GO:0051187)2.52559076
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.52345936
97cholesterol homeostasis (GO:0042632)2.51802716
98sulfur amino acid catabolic process (GO:0000098)2.51158125
99vitamin transmembrane transport (GO:0035461)2.49381167
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49174750
101neurotransmitter catabolic process (GO:0042135)2.49027617
102long-chain fatty acid biosynthetic process (GO:0042759)2.48549847
103regulation of interferon-beta biosynthetic process (GO:0045357)2.47821671
104carnitine shuttle (GO:0006853)2.47751773
105positive regulation of cellular amine metabolic process (GO:0033240)2.47122977
106bile acid metabolic process (GO:0008206)2.46895273
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46679299
108sterol homeostasis (GO:0055092)2.46596283
109regulation of complement activation (GO:0030449)2.45915194
110lipoprotein metabolic process (GO:0042157)2.45854463
111labyrinthine layer development (GO:0060711)2.44156029
112intestinal epithelial cell development (GO:0060576)2.43424149
113regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.42834970
114angiotensin maturation (GO:0002003)2.42622218
115regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.42527418
116positive regulation by symbiont of host defense response (GO:0052509)2.42081725
117modulation by symbiont of host defense response (GO:0052031)2.42081725
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42081725
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42081725
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.42081725
121modulation by symbiont of host immune response (GO:0052553)2.42081725
122granulocyte activation (GO:0036230)2.41800127
123very long-chain fatty acid metabolic process (GO:0000038)2.41404226
124amyloid precursor protein metabolic process (GO:0042982)2.40823201
125immunoglobulin mediated immune response (GO:0016064)2.40630612
126pyridine-containing compound biosynthetic process (GO:0072525)2.40551542
127regulation of antigen processing and presentation (GO:0002577)2.40519630
128negative regulation of protein localization to cell surface (GO:2000009)2.39973332
129cellular glucuronidation (GO:0052695)2.39607842
130phospholipid efflux (GO:0033700)2.39064007
131complement activation (GO:0006956)2.38902854
132muscle atrophy (GO:0014889)2.38647799
133nitrogen cycle metabolic process (GO:0071941)2.38437392
134positive regulation of Cdc42 GTPase activity (GO:0043089)2.38432838
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38378934
136positive regulation of cellular amide metabolic process (GO:0034250)2.37582930
137cell proliferation involved in metanephros development (GO:0072203)2.36846716
138establishment of skin barrier (GO:0061436)2.35483209
139interferon-gamma-mediated signaling pathway (GO:0060333)2.35052685
140positive regulation of humoral immune response (GO:0002922)2.34886930
141positive regulation of chemokine biosynthetic process (GO:0045080)2.34792357
142homocysteine metabolic process (GO:0050667)2.34788753
143aldehyde catabolic process (GO:0046185)2.34724965
144natural killer cell mediated immunity (GO:0002228)2.33602244
145natural killer cell mediated cytotoxicity (GO:0042267)2.33602244
146detection of molecule of bacterial origin (GO:0032490)2.33545498
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.33514661
148positive thymic T cell selection (GO:0045059)2.33061713
149acetyl-CoA metabolic process (GO:0006084)2.32476322
150regulation of water loss via skin (GO:0033561)2.32289403
151glutathione derivative biosynthetic process (GO:1901687)2.31868120
152glutathione derivative metabolic process (GO:1901685)2.31868120
153amino-acid betaine metabolic process (GO:0006577)2.31849375
154positive regulation of lipid catabolic process (GO:0050996)2.31781198
155lung lobe morphogenesis (GO:0060463)2.31720792
156regulation of macrophage chemotaxis (GO:0010758)2.31332690
157negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29972110
158regulation of sterol transport (GO:0032371)2.27709003
159regulation of cholesterol transport (GO:0032374)2.27709003
160response to thyroid hormone (GO:0097066)2.27610662
161detection of biotic stimulus (GO:0009595)2.27062262
162regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26423472
163uronic acid metabolic process (GO:0006063)2.25246772
164glucuronate metabolic process (GO:0019585)2.25246772
165germinal center formation (GO:0002467)2.24754417
166cellular response to ethanol (GO:0071361)2.24606834
167negative regulation of lipid transport (GO:0032369)2.23335815
168regulation of apoptotic cell clearance (GO:2000425)2.23148885
169protein activation cascade (GO:0072376)2.22146467
170transcytosis (GO:0045056)2.20971233
171negative regulation of protein activation cascade (GO:2000258)2.20908434
172keratan sulfate catabolic process (GO:0042340)2.20707037
173positive regulation of gamma-delta T cell activation (GO:0046645)2.19387003
174regulation of humoral immune response (GO:0002920)2.19224845
175lipoprotein transport (GO:0042953)2.18722659
176fat-soluble vitamin biosynthetic process (GO:0042362)2.18109006
177intracellular lipid transport (GO:0032365)2.16488905
178carnitine transport (GO:0015879)2.13443994
179amino-acid betaine transport (GO:0015838)2.13443994
180regulation of gamma-delta T cell activation (GO:0046643)2.12387350
181ethanol oxidation (GO:0006069)2.11636750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.49404579
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.08990022
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.00359286
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.88876244
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.82757739
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.81406993
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.51331160
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.49272761
9* IRF8_22096565_ChIP-ChIP_GC-B_Human2.99269193
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.85013501
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.83047137
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81502307
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75499519
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64121232
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56013498
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.48247201
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.46554304
18* ESR2_21235772_ChIP-Seq_MCF-7_Human2.30394837
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.27400874
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.94253108
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91365130
22* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78852913
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78745499
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77209252
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76885521
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.75508694
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75310865
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.70982264
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69631838
30GATA1_22025678_ChIP-Seq_K562_Human1.69536832
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67719735
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.62276626
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.61741158
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61398345
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59166909
36RUNX_20019798_ChIP-Seq_JUKART_Human1.56924899
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54665594
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52757922
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51458443
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51199003
41* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49816909
42* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48246118
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44617123
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.44450606
45AHR_22903824_ChIP-Seq_MCF-7_Human1.44405700
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41419641
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41419641
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40918850
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39523502
50GATA4_25053715_ChIP-Seq_YYC3_Human1.39100615
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38164802
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35423337
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32451242
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27860463
55* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26887772
56* SOX2_20726797_ChIP-Seq_SW620_Human1.26216271
57* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24636589
58* SPI1_23127762_ChIP-Seq_K562_Human1.24564567
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23054969
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21453950
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19953698
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.18937391
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.18937391
64VDR_24787735_ChIP-Seq_THP-1_Human1.17366985
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15957778
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.14874462
67GATA1_19941826_ChIP-Seq_K562_Human1.14745158
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14254160
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13364119
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11865404
71SMAD3_21741376_ChIP-Seq_HESCs_Human1.11209722
72VDR_24763502_ChIP-Seq_THP-1_Human1.10319018
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10070932
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09005909
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08995904
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.08353655
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08103651
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08084788
79GATA6_25053715_ChIP-Seq_YYC3_Human1.07307747
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.06860164
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06320113
82ZNF263_19887448_ChIP-Seq_K562_Human1.05291896
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02958772
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02422264
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01781896
86* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99504173
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99354471
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98133624
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98133624
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98133624
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97447682
92GATA2_19941826_ChIP-Seq_K562_Human0.97151921
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96853780
94* GATA2_21666600_ChIP-Seq_HMVEC_Human0.96738176
95* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94276397
96SCL_19346495_ChIP-Seq_HPC-7_Human0.94220589
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93824116
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91991920
99EP300_21415370_ChIP-Seq_HL-1_Mouse0.91092853
100HTT_18923047_ChIP-ChIP_STHdh_Human0.90927745
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90216006
102TRIM28_21343339_ChIP-Seq_HEK293_Human0.90071009
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89990893
104NANOG_18692474_ChIP-Seq_MEFs_Mouse0.89986147
105TP53_16413492_ChIP-PET_HCT116_Human0.89739126
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89307256
107CLOCK_20551151_ChIP-Seq_293T_Human0.88989133
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.88344805
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88065051
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87676348
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87536587
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.86388297
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86345286
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86167676
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85862985
116CJUN_26792858_Chip-Seq_BT549_Human0.85664442
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85596134
118LXR_22292898_ChIP-Seq_THP-1_Human0.84388044
119RXR_22108803_ChIP-Seq_LS180_Human0.84163900
120TCF7_22412390_ChIP-Seq_EML_Mouse0.83125205
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83030212
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.82658148
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81410113
124GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80313019
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78598481
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78455852
127TP63_23658742_ChIP-Seq_EP156T_Human0.77339442
128NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77159924
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.76465147
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76355740
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76350716
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76350716
133VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75394309
134* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73639947
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73472393
136CEBPB_22108803_ChIP-Seq_LS180_Human0.73368805
137NANOG_18692474_ChIP-Seq_MESCs_Mouse0.72347850
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72062168
139CDX2_22108803_ChIP-Seq_LS180_Human0.71761726
140* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71113762
141* HNF4A_19822575_ChIP-Seq_HepG2_Human0.70715675
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69405343
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69262162
144ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68901778
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68646755
146BCOR_27268052_Chip-Seq_Bcells_Human0.68385617
147EGR1_19032775_ChIP-ChIP_M12_Human0.68029797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.09170294
2MP0005451_abnormal_body_composition3.62411907
3MP0002139_abnormal_hepatobiliary_system3.33270876
4MP0003806_abnormal_nucleotide_metabolis3.20828854
5MP0005360_urolithiasis3.06276999
6MP0005085_abnormal_gallbladder_physiolo2.99352527
7MP0008260_abnormal_autophagy2.69002660
8MP0000920_abnormal_myelination2.49428142
9MP0003183_abnormal_peptide_metabolism2.47989638
10MP0003950_abnormal_plasma_membrane2.46908737
11MP0006082_CNS_inflammation2.42950055
12MP0005365_abnormal_bile_salt2.41101631
13MP0005058_abnormal_lysosome_morphology2.37162060
14MP0010678_abnormal_skin_adnexa2.29959229
15MP0000383_abnormal_hair_follicle2.29324757
16MP0003283_abnormal_digestive_organ2.27828940
17MP0003690_abnormal_glial_cell2.24420399
18MP0008875_abnormal_xenobiotic_pharmacok2.22097665
19MP0008004_abnormal_stomach_pH2.17539013
20MP0009785_altered_susceptibility_to2.06918796
21MP0003300_gastrointestinal_ulcer1.97046402
22MP0003195_calcinosis1.93192617
23MP0003186_abnormal_redox_activity1.92898607
24MP0001835_abnormal_antigen_presentation1.92393228
25MP0002148_abnormal_hypersensitivity_rea1.87571235
26MP0005083_abnormal_biliary_tract1.87161792
27MP0005332_abnormal_amino_acid1.85828235
28MP0004264_abnormal_extraembryonic_tissu1.82860923
29MP0003172_abnormal_lysosome_physiology1.82697840
30MP0003718_maternal_effect1.82664135
31MP0002254_reproductive_system_inflammat1.81685270
32MP0003191_abnormal_cellular_cholesterol1.81503243
33MP0003453_abnormal_keratinocyte_physiol1.81270307
34MP0005408_hypopigmentation1.79691622
35MP0009764_decreased_sensitivity_to1.73792827
36MP0004381_abnormal_hair_follicle1.73236362
37MP0002419_abnormal_innate_immunity1.64269858
38MP0003656_abnormal_erythrocyte_physiolo1.58718137
39MP0003136_yellow_coat_color1.56017095
40MP0005025_abnormal_response_to1.52344988
41MP0002796_impaired_skin_barrier1.48090567
42MP0010329_abnormal_lipoprotein_level1.46239306
43MP0000579_abnormal_nail_morphology1.44324813
44MP0010155_abnormal_intestine_physiology1.42336455
45MP0000604_amyloidosis1.41639079
46MP0000647_abnormal_sebaceous_gland1.40955184
47MP0005670_abnormal_white_adipose1.38391816
48MP0005671_abnormal_response_to1.38201418
49MP0004947_skin_inflammation1.34652886
50MP0001666_abnormal_nutrient_absorption1.33914391
51MP0005275_abnormal_skin_tensile1.33210145
52MP0004019_abnormal_vitamin_homeostasis1.32603094
53MP0003436_decreased_susceptibility_to1.32484407
54MP0003724_increased_susceptibility_to1.31962468
55MP0005171_absent_coat_pigmentation1.31550439
56MP0002118_abnormal_lipid_homeostasis1.31053657
57MP0001661_extended_life_span1.28195795
58MP0003252_abnormal_bile_duct1.22480844
59MP0009697_abnormal_copulation1.22110508
60MP0008469_abnormal_protein_level1.20626540
61MP0001346_abnormal_lacrimal_gland1.20187990
62MP0005000_abnormal_immune_tolerance1.19790159
63MP0000609_abnormal_liver_physiology1.19468883
64MP0003868_abnormal_feces_composition1.19066306
65MP0002166_altered_tumor_susceptibility1.17963224
66MP0000685_abnormal_immune_system1.12965544
67MP0009643_abnormal_urine_homeostasis1.09633017
68MP0002098_abnormal_vibrissa_morphology1.07950693
69MP0005409_darkened_coat_color1.07882701
70MP0005319_abnormal_enzyme/_coenzyme1.07456464
71MP0002998_abnormal_bone_remodeling1.07055470
72MP0001756_abnormal_urination1.05839312
73MP0000465_gastrointestinal_hemorrhage1.05565856
74MP0003646_muscle_fatigue1.04650038
75MP0002723_abnormal_immune_serum1.03292550
76MP0003045_fibrosis1.02625724
77MP0003448_altered_tumor_morphology1.01361442
78MP0003879_abnormal_hair_cell0.99442510
79MP0001790_abnormal_immune_system0.98398002
80MP0005387_immune_system_phenotype0.98398002
81MP0004510_myositis0.98376184
82MP0009115_abnormal_fat_cell0.98325144
83MP0005167_abnormal_blood-brain_barrier0.98264304
84MP0003075_altered_response_to0.97880994
85MP0002452_abnormal_antigen_presenting0.96260898
86MP0002971_abnormal_brown_adipose0.95510309
87MP0001845_abnormal_inflammatory_respons0.95303288
88MP0005395_other_phenotype0.94993354
89MP0003091_abnormal_cell_migration0.94667475
90MP0005310_abnormal_salivary_gland0.93214583
91MP0005023_abnormal_wound_healing0.90219122
92MP0005464_abnormal_platelet_physiology0.89965943
93MP0010352_gastrointestinal_tract_polyps0.89746553
94MP0000371_diluted_coat_color0.89721166
95MP0010386_abnormal_urinary_bladder0.89612687
96MP0009763_increased_sensitivity_to0.89600576
97MP0002295_abnormal_pulmonary_circulatio0.88262157
98MP0005666_abnormal_adipose_tissue0.88101358
99MP0001873_stomach_inflammation0.87757010
100MP0005584_abnormal_enzyme/coenzyme_acti0.87158955
101MP0003329_amyloid_beta_deposits0.87024814
102MP0002136_abnormal_kidney_physiology0.86421508
103MP0005164_abnormal_response_to0.86302831
104MP0003828_pulmonary_edema0.86292105
105MP0002138_abnormal_hepatobiliary_system0.86130737
106MP0001819_abnormal_immune_cell0.85816933
107MP0002420_abnormal_adaptive_immunity0.85507853
108MP0001216_abnormal_epidermal_layer0.85084291
109MP0001800_abnormal_humoral_immune0.84303616
110MP0000377_abnormal_hair_follicle0.83555201
111MP0010234_abnormal_vibrissa_follicle0.83197879
112MP0002822_catalepsy0.82198545
113MP0004885_abnormal_endolymph0.81083448
114MP0002009_preneoplasia0.77776283
115MP0004185_abnormal_adipocyte_glucose0.77698923
116MP0006138_congestive_heart_failure0.77647103
117MP0000372_irregular_coat_pigmentation0.77579554
118MP0005257_abnormal_intraocular_pressure0.76599798
119MP0004883_abnormal_blood_vessel0.76298605
120MP0000516_abnormal_urinary_system0.76269909
121MP0005367_renal/urinary_system_phenotyp0.76269909
122MP0000343_altered_response_to0.76146349
123MP0005647_abnormal_sex_gland0.75510684
124MP0005166_decreased_susceptibility_to0.73739036
125MP0001533_abnormal_skeleton_physiology0.73618174
126MP0004782_abnormal_surfactant_physiolog0.73558433
127MP0006054_spinal_hemorrhage0.73495088
128MP0001881_abnormal_mammary_gland0.71683027
129MP0009765_abnormal_xenobiotic_induced0.69981420
130MP0003566_abnormal_cell_adhesion0.69956819
131MP0000627_abnormal_mammary_gland0.69061002
132MP0002405_respiratory_system_inflammati0.66968724
133MP0009333_abnormal_splenocyte_physiolog0.66615549
134MP0003303_peritoneal_inflammation0.65768915
135MP0001853_heart_inflammation0.65500562

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.28187858
2Intrahepatic cholestasis (HP:0001406)4.20711850
3Parakeratosis (HP:0001036)4.04990101
4Malnutrition (HP:0004395)3.81734985
5Xanthomatosis (HP:0000991)3.80301664
6Asymmetric septal hypertrophy (HP:0001670)3.67755775
7Hyperlipoproteinemia (HP:0010980)3.60044433
8Axonal loss (HP:0003447)3.44977791
9Abnormality of macrophages (HP:0004311)3.42625583
10Recurrent bacterial skin infections (HP:0005406)3.34712693
11Recurrent gram-negative bacterial infections (HP:0005420)3.34174132
12Deep venous thrombosis (HP:0002625)3.31937590
13Muscle fiber splitting (HP:0003555)3.25668518
14Abnormality of glycine metabolism (HP:0010895)3.18184203
15Abnormality of serine family amino acid metabolism (HP:0010894)3.18184203
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.12038505
17Hyperglycinemia (HP:0002154)3.11262079
18Dysostosis multiplex (HP:0000943)3.11090445
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.10394092
20Neurofibrillary tangles (HP:0002185)3.06469284
21Hyperglycinuria (HP:0003108)3.06024116
22Vacuolated lymphocytes (HP:0001922)2.94140616
23Gastrointestinal stroma tumor (HP:0100723)2.93274380
24Myocardial infarction (HP:0001658)2.91324966
25Prolonged partial thromboplastin time (HP:0003645)2.91242018
26Prolonged neonatal jaundice (HP:0006579)2.85654163
27Mucopolysacchariduria (HP:0008155)2.84971226
28Urinary glycosaminoglycan excretion (HP:0003541)2.84971226
29Congenital ichthyosiform erythroderma (HP:0007431)2.84319682
30Hemorrhage of the eye (HP:0011885)2.79808827
31Hepatosplenomegaly (HP:0001433)2.79124770
32Recurrent abscess formation (HP:0002722)2.77929729
33Abnormality of polysaccharide metabolism (HP:0011012)2.73127178
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73127178
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73127178
36Pustule (HP:0200039)2.71656803
37Eczematoid dermatitis (HP:0000976)2.68634187
38Spastic paraparesis (HP:0002313)2.66538244
39Osteolytic defects of the hand bones (HP:0009699)2.65448566
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.65448566
41Increased IgE level (HP:0003212)2.62375216
42Exercise-induced myalgia (HP:0003738)2.62123524
43Paraparesis (HP:0002385)2.59304318
44Cerebral hemorrhage (HP:0001342)2.57993867
45Complement deficiency (HP:0004431)2.56760525
46Hypobetalipoproteinemia (HP:0003563)2.55187235
47Systemic lupus erythematosus (HP:0002725)2.54915363
48Fat malabsorption (HP:0002630)2.53390717
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51411666
50Thick nail (HP:0001805)2.49573695
51Segmental peripheral demyelination/remyelination (HP:0003481)2.47822509
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.47430764
53Vascular calcification (HP:0004934)2.40225030
54Erythroderma (HP:0001019)2.39376481
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37707589
56Joint hemorrhage (HP:0005261)2.37701594
57Cerebral hypomyelination (HP:0006808)2.37328446
58Hyporeflexia of lower limbs (HP:0002600)2.36835517
59Spastic tetraparesis (HP:0001285)2.36564116
60Colitis (HP:0002583)2.36561396
61Steatorrhea (HP:0002570)2.36477072
62Abnormality of serum amino acid levels (HP:0003112)2.35814709
63Glomerulonephritis (HP:0000099)2.34738530
64Abnormality of methionine metabolism (HP:0010901)2.34215278
65Epidermoid cyst (HP:0200040)2.32451372
66Hydroxyprolinuria (HP:0003080)2.24789365
67Abnormality of proline metabolism (HP:0010907)2.24789365
68Right ventricular cardiomyopathy (HP:0011663)2.24304454
69Hyperammonemia (HP:0001987)2.24280776
70Alopecia of scalp (HP:0002293)2.24164353
71Abnormality of fatty-acid metabolism (HP:0004359)2.22818472
72Hypolipoproteinemia (HP:0010981)2.21868864
73Loss of speech (HP:0002371)2.20873767
74Gingival bleeding (HP:0000225)2.20154661
75Emphysema (HP:0002097)2.19008327
76Peripheral demyelination (HP:0011096)2.18312445
77Hypoalphalipoproteinemia (HP:0003233)2.18219893
78Stenosis of the external auditory canal (HP:0000402)2.17469645
79Recurrent skin infections (HP:0001581)2.17022818
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.14318693
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14318693
82Conjugated hyperbilirubinemia (HP:0002908)2.13379368
83Onion bulb formation (HP:0003383)2.11767454
84Purpura (HP:0000979)2.10070763
85Polycythemia (HP:0001901)2.09315763
86Abnormality of liposaccharide metabolism (HP:0010968)2.09097582
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.09097582
88Abnormality of glycolipid metabolism (HP:0010969)2.09097582
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08552727
90Osteomyelitis (HP:0002754)2.08550271
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08472771
92Recurrent pneumonia (HP:0006532)2.07118525
93Vasculitis (HP:0002633)2.04937048
94Amyloidosis (HP:0011034)2.04710576
95Esophageal varix (HP:0002040)2.04633664
96Nausea (HP:0002018)2.04465400
97Neonatal hypoglycemia (HP:0001998)2.02705152
98Ureteral duplication (HP:0000073)2.02663456
99Restrictive lung disease (HP:0002091)2.02360341
100Recurrent sinusitis (HP:0011108)2.02295180
101Increased neuronal autofluorescent lipopigment (HP:0002074)2.02177890
102Cardiovascular calcification (HP:0011915)2.01754985
103Hyperkalemia (HP:0002153)1.99254600
104Autoimmune thrombocytopenia (HP:0001973)1.98959854
105Gastrointestinal infarctions (HP:0005244)1.98162756
106Joint swelling (HP:0001386)1.96275217
107Nephritis (HP:0000123)1.95921602
108Chronic diarrhea (HP:0002028)1.95760607
109Abnormality of complement system (HP:0005339)1.94870971
110Aortic aneurysm (HP:0004942)1.93446628
111Increased cerebral lipofuscin (HP:0011813)1.92869435
112Abnormality of secondary sexual hair (HP:0009888)1.92558329
113Abnormality of the axillary hair (HP:0100134)1.92558329
114Autoamputation (HP:0001218)1.90947991
115Abnormality of the umbilical cord (HP:0010881)1.90678526
116Spontaneous abortion (HP:0005268)1.90627635
117Gastrointestinal inflammation (HP:0004386)1.90357539
118Inflammation of the large intestine (HP:0002037)1.90313272
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89972987
120Flat acetabular roof (HP:0003180)1.89935718
121Gingivitis (HP:0000230)1.88757511
122Orchitis (HP:0100796)1.85545688
123Abnormality of the common coagulation pathway (HP:0010990)1.84714038
124Increased serum ferritin (HP:0003281)1.84381022
125Gangrene (HP:0100758)1.83741627
126Meningitis (HP:0001287)1.83413598
127Interstitial pulmonary disease (HP:0006530)1.82438230
128Lip pit (HP:0100267)1.81822830
129Mediastinal lymphadenopathy (HP:0100721)1.81289366
130Stomatitis (HP:0010280)1.81124936
131Cerebral inclusion bodies (HP:0100314)1.79298226
132Corneal erosion (HP:0200020)1.78125978
133Abnormality of transition element cation homeostasis (HP:0011030)1.77923455
134Abnormality of iron homeostasis (HP:0011031)1.77868350
135Hypercholesterolemia (HP:0003124)1.76637695
136Retrobulbar optic neuritis (HP:0100654)1.75988717
137Optic neuritis (HP:0100653)1.75988717
138Focal segmental glomerulosclerosis (HP:0000097)1.75818963
139Slow saccadic eye movements (HP:0000514)1.75363461
140Spondylolisthesis (HP:0003302)1.75138213
141Tetraparesis (HP:0002273)1.74960934
142Cerebral aneurysm (HP:0004944)1.74570013
143Irritability (HP:0000737)1.74069917
144Abnormality of the periventricular white matter (HP:0002518)1.74041370
145Spontaneous hematomas (HP:0007420)1.70518481
146Gonadotropin excess (HP:0000837)1.69152288
147Agammaglobulinemia (HP:0004432)1.68922848
148Metaphyseal irregularity (HP:0003025)1.68625988
149Hypophosphatemic rickets (HP:0004912)1.68537392
150Ovoid vertebral bodies (HP:0003300)1.67248310
151Hyperactive renin-angiotensin system (HP:0000841)1.66068969
152Recurrent bronchitis (HP:0002837)1.65558253
153Rhabdomyolysis (HP:0003201)1.62946806
154Pulmonary infiltrates (HP:0002113)1.62798667
155Thin bony cortex (HP:0002753)1.61933205
156Cellulitis (HP:0100658)1.61660819
157Pulmonary embolism (HP:0002204)1.61469274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.82243159
2STK393.57119589
3ERN13.16727236
4EPHB13.12358390
5ACVR1B2.95100893
6MST42.88436149
7MAP3K142.85162370
8MET2.73324514
9OXSR12.54592527
10DDR22.17612086
11RIPK12.07636144
12EPHA22.05485884
13BLK2.01336677
14PKN11.98166469
15PINK11.92299021
16MAP3K131.90556990
17MST1R1.88552515
18EEF2K1.87793521
19TBK11.83505193
20IRAK31.82938757
21ERBB41.73222661
22IKBKB1.67371745
23BCKDK1.65007025
24TYK21.63756777
25CDC42BPA1.63008148
26FGFR31.60949795
27FGFR21.54940293
28MAP4K11.54785556
29AKT31.51797474
30FGR1.51495802
31CDK121.49833840
32TRIB31.48409500
33BCR1.48123259
34ARAF1.44754239
35TNK21.43984052
36RIPK41.34713739
37MAPKAPK31.33722025
38NTRK11.31748499
39IKBKE1.30220975
40STK31.28721281
41MATK1.24840242
42TRPM71.24778340
43TGFBR21.18592871
44PRPF4B1.18292685
45NME21.16571658
46NLK1.15088758
47GRK71.14425597
48PNCK1.11192123
49MAP3K21.09641456
50STK41.06823161
51LATS11.04594880
52CSNK1G11.02268916
53CSNK1G31.01984643
54CAMK1D1.01911853
55MAPKAPK51.00831051
56PLK40.97088871
57MAP3K70.96867041
58MARK20.95170635
59MAP3K100.95070441
60ABL20.94982213
61MAPK120.94871458
62FER0.94193182
63MAP2K20.93590580
64CSNK1A1L0.92572280
65SIK10.91187202
66FGFR40.90330040
67DMPK0.88196524
68STK100.88052294
69SGK20.87853974
70NEK90.87270978
71FRK0.87023430
72MAPK110.87021186
73EPHA30.85499183
74KIT0.84706776
75PDK10.84357191
76OBSCN0.83450562
77BMPR1B0.83231935
78NUAK10.82782383
79PDK20.81459452
80MAP3K10.81142034
81CAMK2G0.80461744
82SGK30.79509416
83PDPK10.77954508
84CSK0.76445545
85EIF2AK30.75611065
86JAK10.74145099
87JAK30.72593106
88TNIK0.71328479
89SYK0.71205101
90STK240.70971301
91CHUK0.70819211
92BMX0.69395065
93TAOK30.69314769
94CAMK1G0.68008882
95LYN0.67340033
96PDGFRA0.65891719
97MAP2K30.65874047
98TAOK10.63476586
99PRKD20.62691607
100IRAK40.62663276
101KSR20.60327443
102WNK40.60274396
103CSF1R0.60211166
104ZAP700.60031086
105CAMK2D0.59720526
106NEK60.58807580
107BUB10.58638907
108CSNK1G20.58586105
109PRKG20.56986640
110GSK3A0.56962245
111WNK10.56049660
112TTN0.55701466
113ABL10.55658785
114PIK3CA0.55476975
115BRAF0.53069474
116BTK0.53022460
117PAK30.52644591
118ICK0.52585901
119PIK3CG0.50955884
120SGK4940.50739796
121SGK2230.50739796
122PKN20.50688416
123CDK190.49760670
124PRKCQ0.49385713
125PIM20.48795033
126STK38L0.48113314
127JAK20.47533748
128LRRK20.47220313
129PRKAA20.46724719
130MARK30.46311732
131BMPR20.46029698
132TGFBR10.46003507
133MELK0.45992787
134CDK90.45735282
135HCK0.44956429
136PDGFRB0.44956166
137RET0.44126716
138WEE10.43581404
139ERBB20.43417281
140MUSK0.42570984
141PAK20.42477909
142RPS6KA50.42060506
143RPS6KA20.41137053
144MAPK70.40763026
145CAMK2B0.40680879
146TYRO30.40533433
147MOS0.40368803
148EGFR0.39238189
149PRKCE0.38165454
150MAP3K30.37099745
151IRAK10.35652027
152PRKD10.35217398
153EIF2AK20.35130241
154DAPK30.34846968

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.47558407
2Steroid biosynthesis_Homo sapiens_hsa001002.80228214
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.75687637
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.56233801
5Staphylococcus aureus infection_Homo sapiens_hsa051502.49891542
6Histidine metabolism_Homo sapiens_hsa003402.48065714
7Fatty acid elongation_Homo sapiens_hsa000622.41784944
8Nitrogen metabolism_Homo sapiens_hsa009102.28274727
9Folate biosynthesis_Homo sapiens_hsa007902.24508297
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04013839
11Graft-versus-host disease_Homo sapiens_hsa053321.90226118
12Arginine biosynthesis_Homo sapiens_hsa002201.85699827
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85488709
14Complement and coagulation cascades_Homo sapiens_hsa046101.81173250
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80500595
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71999296
17Tryptophan metabolism_Homo sapiens_hsa003801.71937152
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63700171
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62582051
20Peroxisome_Homo sapiens_hsa041461.59230641
21Arginine and proline metabolism_Homo sapiens_hsa003301.54032904
22Fatty acid degradation_Homo sapiens_hsa000711.53536887
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51247440
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50727498
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.45476848
26Vitamin digestion and absorption_Homo sapiens_hsa049771.43017480
27Tyrosine metabolism_Homo sapiens_hsa003501.42393162
28Ether lipid metabolism_Homo sapiens_hsa005651.41075518
29Fatty acid metabolism_Homo sapiens_hsa012121.39694172
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.35972731
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35360322
32Phenylalanine metabolism_Homo sapiens_hsa003601.34626407
33Chemical carcinogenesis_Homo sapiens_hsa052041.34404862
34Sulfur metabolism_Homo sapiens_hsa009201.33239921
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32571620
36Caffeine metabolism_Homo sapiens_hsa002321.30809400
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30041594
38PPAR signaling pathway_Homo sapiens_hsa033201.26358268
39Rheumatoid arthritis_Homo sapiens_hsa053231.25718313
40Lysosome_Homo sapiens_hsa041421.25197104
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23857619
42B cell receptor signaling pathway_Homo sapiens_hsa046621.22299924
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21600321
44beta-Alanine metabolism_Homo sapiens_hsa004101.21440472
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.20888641
46Allograft rejection_Homo sapiens_hsa053301.19348120
47Retinol metabolism_Homo sapiens_hsa008301.17044343
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13541890
49Linoleic acid metabolism_Homo sapiens_hsa005911.12515189
50Type I diabetes mellitus_Homo sapiens_hsa049401.11274247
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.07907327
52Propanoate metabolism_Homo sapiens_hsa006401.07476429
53Butanoate metabolism_Homo sapiens_hsa006501.06495039
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03042427
55Malaria_Homo sapiens_hsa051441.01268594
56Toxoplasmosis_Homo sapiens_hsa051450.99522465
57Glutathione metabolism_Homo sapiens_hsa004800.96923053
58Insulin resistance_Homo sapiens_hsa049310.95174312
59Regulation of autophagy_Homo sapiens_hsa041400.94910476
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.92853105
61Fatty acid biosynthesis_Homo sapiens_hsa000610.92479847
62Legionellosis_Homo sapiens_hsa051340.91616073
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87238097
64Leishmaniasis_Homo sapiens_hsa051400.86754671
65Renin-angiotensin system_Homo sapiens_hsa046140.86664470
66Pertussis_Homo sapiens_hsa051330.86266306
67Viral myocarditis_Homo sapiens_hsa054160.86079909
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85786922
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84261494
70Sphingolipid metabolism_Homo sapiens_hsa006000.84254442
71African trypanosomiasis_Homo sapiens_hsa051430.81712444
72Mineral absorption_Homo sapiens_hsa049780.79475424
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79138021
74Antigen processing and presentation_Homo sapiens_hsa046120.73151921
75Prion diseases_Homo sapiens_hsa050200.71701340
76Proteasome_Homo sapiens_hsa030500.71126760
77Prolactin signaling pathway_Homo sapiens_hsa049170.70241784
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69404085
79Autoimmune thyroid disease_Homo sapiens_hsa053200.69304852
80Galactose metabolism_Homo sapiens_hsa000520.68687310
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68411072
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67183639
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66897392
84Fructose and mannose metabolism_Homo sapiens_hsa000510.66849999
85Fat digestion and absorption_Homo sapiens_hsa049750.66709013
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.65898998
87ABC transporters_Homo sapiens_hsa020100.65827187
88Ovarian steroidogenesis_Homo sapiens_hsa049130.65135142
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64626564
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63836119
91Pentose phosphate pathway_Homo sapiens_hsa000300.63416053
92Phagosome_Homo sapiens_hsa041450.63114656
93Arachidonic acid metabolism_Homo sapiens_hsa005900.62507506
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.59435383
95Selenocompound metabolism_Homo sapiens_hsa004500.58697161
96Bile secretion_Homo sapiens_hsa049760.58293388
97Glycerolipid metabolism_Homo sapiens_hsa005610.57289058
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.56615346
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.56507645
100Circadian rhythm_Homo sapiens_hsa047100.56339600
101TNF signaling pathway_Homo sapiens_hsa046680.55772344
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.55457954
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55110407
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54285960
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53272806
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.52770758
107Tuberculosis_Homo sapiens_hsa051520.52212529
108Salmonella infection_Homo sapiens_hsa051320.51732363
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50129185
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49373700
111Protein digestion and absorption_Homo sapiens_hsa049740.48236249
112Herpes simplex infection_Homo sapiens_hsa051680.46516157
113Inositol phosphate metabolism_Homo sapiens_hsa005620.46266151
114Acute myeloid leukemia_Homo sapiens_hsa052210.45997262
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45108962
116Insulin signaling pathway_Homo sapiens_hsa049100.44557372
117Hepatitis C_Homo sapiens_hsa051600.44336384
118Osteoclast differentiation_Homo sapiens_hsa043800.43563527
119Amoebiasis_Homo sapiens_hsa051460.43496818
120Asthma_Homo sapiens_hsa053100.42075014
121Glucagon signaling pathway_Homo sapiens_hsa049220.41430854
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41012654
123Metabolic pathways_Homo sapiens_hsa011000.40492021
124Dorso-ventral axis formation_Homo sapiens_hsa043200.40080527
125Starch and sucrose metabolism_Homo sapiens_hsa005000.39751413
126Platelet activation_Homo sapiens_hsa046110.39722102
127Hematopoietic cell lineage_Homo sapiens_hsa046400.39325401
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38233204
129Other glycan degradation_Homo sapiens_hsa005110.37349563
130Chemokine signaling pathway_Homo sapiens_hsa040620.36360393
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36201035
132Influenza A_Homo sapiens_hsa051640.35818686
133Biosynthesis of amino acids_Homo sapiens_hsa012300.34124269
134Carbon metabolism_Homo sapiens_hsa012000.33852536
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32255944

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