PPHLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.65765724
2lactate metabolic process (GO:0006089)4.60533937
3protein localization to kinetochore (GO:0034501)4.42020031
4nuclear pore complex assembly (GO:0051292)4.41255193
5nuclear pore organization (GO:0006999)4.37500537
6kinetochore organization (GO:0051383)4.26968915
7mitotic sister chromatid cohesion (GO:0007064)4.09578054
8DNA replication checkpoint (GO:0000076)4.09380385
9proteasome assembly (GO:0043248)4.06777362
10metaphase plate congression (GO:0051310)4.04955023
11protein localization to chromosome, centromeric region (GO:0071459)4.02186384
12attachment of spindle microtubules to kinetochore (GO:0008608)3.90098413
13kinetochore assembly (GO:0051382)3.90056832
14mitotic nuclear envelope disassembly (GO:0007077)3.89838862
15regulation of spindle organization (GO:0090224)3.87023094
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86257879
17DNA unwinding involved in DNA replication (GO:0006268)3.84888249
18CENP-A containing nucleosome assembly (GO:0034080)3.82863248
19chromatin remodeling at centromere (GO:0031055)3.75573321
20ribosome assembly (GO:0042255)3.72356298
21DNA replication initiation (GO:0006270)3.70062922
22DNA replication-independent nucleosome organization (GO:0034724)3.68832500
23DNA replication-independent nucleosome assembly (GO:0006336)3.68832500
24spindle checkpoint (GO:0031577)3.66336634
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.66275324
26DNA strand elongation involved in DNA replication (GO:0006271)3.64393158
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62504958
28nuclear envelope disassembly (GO:0051081)3.62356352
29membrane disassembly (GO:0030397)3.62356352
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.60718452
31histone exchange (GO:0043486)3.59510069
32negative regulation of mitotic sister chromatid separation (GO:2000816)3.57460779
33negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57460779
34negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57460779
35negative regulation of sister chromatid segregation (GO:0033046)3.57460779
36negative regulation of chromosome segregation (GO:0051985)3.56510201
37establishment of chromosome localization (GO:0051303)3.56504398
38regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55631271
39spindle assembly checkpoint (GO:0071173)3.55149208
40purine nucleobase biosynthetic process (GO:0009113)3.53647123
41DNA double-strand break processing (GO:0000729)3.53263741
42mitotic spindle assembly checkpoint (GO:0007094)3.51134084
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48552729
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48414051
45mitotic spindle checkpoint (GO:0071174)3.48384149
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.48246504
47mitotic chromosome condensation (GO:0007076)3.47660761
48pore complex assembly (GO:0046931)3.47639425
49regulation of chromosome segregation (GO:0051983)3.47434061
50nucleobase biosynthetic process (GO:0046112)3.47143744
51DNA strand elongation (GO:0022616)3.46817460
52positive regulation of chromosome segregation (GO:0051984)3.44564429
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.43881687
54replication fork processing (GO:0031297)3.41147326
55ribosome biogenesis (GO:0042254)3.39480789
56telomere maintenance via semi-conservative replication (GO:0032201)3.38339342
57centriole replication (GO:0007099)3.32475524
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31636284
59regulation of sister chromatid segregation (GO:0033045)3.31525564
60regulation of mitotic sister chromatid separation (GO:0010965)3.31525564
61regulation of mitotic sister chromatid segregation (GO:0033047)3.31525564
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31486729
63telomere maintenance via recombination (GO:0000722)3.31273162
64DNA replication-dependent nucleosome assembly (GO:0006335)3.30214598
65DNA replication-dependent nucleosome organization (GO:0034723)3.30214598
66mitotic sister chromatid segregation (GO:0000070)3.27774791
67ribosomal small subunit assembly (GO:0000028)3.27473276
68mitotic recombination (GO:0006312)3.26520252
69meiotic chromosome segregation (GO:0045132)3.25984834
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25351085
71ATP synthesis coupled proton transport (GO:0015986)3.25351085
72sister chromatid segregation (GO:0000819)3.23885151
73pre-miRNA processing (GO:0031054)3.23425595
74regulation of mitotic spindle organization (GO:0060236)3.22583317
75protein localization to chromosome (GO:0034502)3.20467377
76pseudouridine synthesis (GO:0001522)3.20231669
77mitochondrial respiratory chain complex assembly (GO:0033108)3.19105449
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18967424
79protein complex biogenesis (GO:0070271)3.17985473
80regulation of RNA export from nucleus (GO:0046831)3.15857904
81respiratory chain complex IV assembly (GO:0008535)3.14887769
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08844585
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.08844585
84NADH dehydrogenase complex assembly (GO:0010257)3.08844585
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.06121433
86termination of RNA polymerase III transcription (GO:0006386)3.06121433
87DNA synthesis involved in DNA repair (GO:0000731)3.05530902
88protein K6-linked ubiquitination (GO:0085020)3.05503863
89regulation of centriole replication (GO:0046599)3.04286743
90ATP-dependent chromatin remodeling (GO:0043044)3.03298176
91microtubule depolymerization (GO:0007019)3.03012775
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02964039
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02964039
94positive regulation of mitotic sister chromatid separation (GO:1901970)3.02964039
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00862628
96histone mRNA metabolic process (GO:0008334)3.00406769
97regulation of centrosome cycle (GO:0046605)3.00089900
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99363197
99rRNA modification (GO:0000154)2.98903794
100chromosome segregation (GO:0007059)2.97926318
101negative regulation of DNA-dependent DNA replication (GO:2000104)2.97680642
102DNA catabolic process, exonucleolytic (GO:0000738)2.97128944
103chromatin assembly or disassembly (GO:0006333)2.96320001
104telomere maintenance via telomere lengthening (GO:0010833)2.95849907
105regulation of double-strand break repair via homologous recombination (GO:0010569)2.95590042
106histone-serine phosphorylation (GO:0035404)2.95323058
107sister chromatid cohesion (GO:0007062)2.94731675
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93625729
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.93566875
110positive regulation of histone H3-K4 methylation (GO:0051571)2.93085163
111histone H2A acetylation (GO:0043968)2.91549587
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91434801
113monoubiquitinated protein deubiquitination (GO:0035520)2.89877968
114formation of translation preinitiation complex (GO:0001731)2.87532069
115maturation of 5.8S rRNA (GO:0000460)2.86943608
116DNA deamination (GO:0045006)2.86506836
117spliceosomal snRNP assembly (GO:0000387)2.85858421
118negative regulation of ligase activity (GO:0051352)2.85821682
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85821682
120synaptonemal complex assembly (GO:0007130)2.84945777
121nuclear envelope organization (GO:0006998)2.84755563
122cytochrome complex assembly (GO:0017004)2.84571301
123regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84555289
124regulation of mitotic spindle checkpoint (GO:1903504)2.84555289
125recombinational repair (GO:0000725)2.82172427
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.81308864
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81308864
128regulation of Golgi to plasma membrane protein transport (GO:0042996)2.80511789
129double-strand break repair via homologous recombination (GO:0000724)2.79593645
130DNA ligation (GO:0006266)2.77791974
131piRNA metabolic process (GO:0034587)2.77687067
132translesion synthesis (GO:0019985)2.77422475
133IMP biosynthetic process (GO:0006188)2.76911626
134synapsis (GO:0007129)2.76173212
135postreplication repair (GO:0006301)2.74895641
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74144751
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74144751
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74144751
139indolalkylamine metabolic process (GO:0006586)2.74138955
140nucleotide-excision repair, DNA gap filling (GO:0006297)2.73343804
141intra-S DNA damage checkpoint (GO:0031573)2.72533703
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72288114
143respiratory electron transport chain (GO:0022904)2.72281289
144regulation of sister chromatid cohesion (GO:0007063)2.72180101
145RNA splicing, via transesterification reactions (GO:0000375)2.71551682
146signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70538974
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70538974
148negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70523750
149DNA damage response, detection of DNA damage (GO:0042769)2.70219237
150cullin deneddylation (GO:0010388)2.70127968
151RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.68886523
152mRNA splicing, via spliceosome (GO:0000398)2.68886523
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68369510
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68267734
155electron transport chain (GO:0022900)2.65656592
156cytidine metabolic process (GO:0046087)2.64003658
157cytidine catabolic process (GO:0006216)2.64003658
158cytidine deamination (GO:0009972)2.64003658
159mitochondrial RNA metabolic process (GO:0000959)2.63057665
160somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61845959
161isotype switching (GO:0045190)2.61845959
162somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61845959
163transcription from RNA polymerase III promoter (GO:0006383)2.61844892
164rRNA methylation (GO:0031167)2.61710028
165signal transduction involved in DNA integrity checkpoint (GO:0072401)2.60390787
166signal transduction involved in DNA damage checkpoint (GO:0072422)2.60390787
167signal transduction involved in cell cycle checkpoint (GO:0072395)2.58773614
168regulation of DNA endoreduplication (GO:0032875)2.56865239
169positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55506147
170rRNA processing (GO:0006364)2.55184892
171tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51884833
172RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51884833
173regulation of cellular amino acid metabolic process (GO:0006521)2.50992396
174rRNA metabolic process (GO:0016072)2.50722278
175protein deneddylation (GO:0000338)2.49688334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42915175
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.08765266
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49407070
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.82344809
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.70426238
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56262823
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.98522752
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66705417
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.65671410
10AR_21909140_ChIP-Seq_LNCAP_Human2.64313631
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61762010
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58668627
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57212448
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.55740888
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52999165
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.42005119
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.35634399
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34129038
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33177978
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29353075
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.25911481
22ZNF274_21170338_ChIP-Seq_K562_Hela2.22586933
23VDR_23849224_ChIP-Seq_CD4+_Human2.22465525
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21511675
25* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20275825
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15462553
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.08086032
28XRN2_22483619_ChIP-Seq_HELA_Human2.07331129
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07131220
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04525951
31FUS_26573619_Chip-Seq_HEK293_Human1.98292047
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94286058
33ELK1_19687146_ChIP-ChIP_HELA_Human1.93959726
34VDR_22108803_ChIP-Seq_LS180_Human1.92778354
35FOXP3_21729870_ChIP-Seq_TREG_Human1.88448986
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87041923
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84533897
38IGF1R_20145208_ChIP-Seq_DFB_Human1.83659555
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83065931
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82864393
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78600605
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.77960244
43GABP_19822575_ChIP-Seq_HepG2_Human1.76642470
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.71941828
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71283684
46DCP1A_22483619_ChIP-Seq_HELA_Human1.69691238
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69666814
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.68954772
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68941185
50TTF2_22483619_ChIP-Seq_HELA_Human1.65785927
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65779977
52KDM5A_27292631_Chip-Seq_BREAST_Human1.62818393
53MYC_22102868_ChIP-Seq_BL_Human1.57090309
54TAF15_26573619_Chip-Seq_HEK293_Human1.57047746
55CIITA_25753668_ChIP-Seq_RAJI_Human1.56101369
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54567633
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53745049
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50685202
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48763604
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47968091
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45948697
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45394377
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43916408
64* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43040712
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41378756
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39780657
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39502495
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37736140
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37487930
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33352233
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.32790319
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29239471
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27406199
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24118934
75IRF1_19129219_ChIP-ChIP_H3396_Human1.21571457
76* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21130782
77P300_19829295_ChIP-Seq_ESCs_Human1.20344988
78* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18701752
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17880033
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16748158
81ER_23166858_ChIP-Seq_MCF-7_Human1.15240397
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15160186
83FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13288824
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12456608
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12199096
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10848568
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10172087
88TP53_22573176_ChIP-Seq_HFKS_Human1.07899264
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06993437
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06942340
91SPI1_23547873_ChIP-Seq_NB4_Human1.06077956
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05357669
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05153264
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.04821829
95TFEB_21752829_ChIP-Seq_HELA_Human1.04784293
96GATA3_26560356_Chip-Seq_TH2_Human1.04644779
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03908731
98GBX2_23144817_ChIP-Seq_PC3_Human1.03115495
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02808615
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01143201
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00841036
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00410621
103NFE2_27457419_Chip-Seq_LIVER_Mouse0.99259408
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98990456
105MYC_18940864_ChIP-ChIP_HL60_Human0.98382400
106CBP_20019798_ChIP-Seq_JUKART_Human0.98010404
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98010404
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.97378262
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97079090
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96359804
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95328102
112* SALL4_22934838_ChIP-ChIP_CD34+_Human0.94458743
113CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93602447
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93393677
115* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93323989
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93161548
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90857212
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89423780
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87256646
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84830690
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.84356384
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84356384
123IRF8_21731497_ChIP-ChIP_J774_Mouse0.83188597
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82900606
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82837094
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81901518
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81854343
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.80861334
129MYB_26560356_Chip-Seq_TH2_Human0.79314738
130MYB_26560356_Chip-Seq_TH1_Human0.75932795
131* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75850650
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74664630
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73617267
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.72625920
135* NANOG_21062744_ChIP-ChIP_HESCs_Human0.72570316
136CHD1_26751641_Chip-Seq_LNCaP_Human0.72336717
137VDR_21846776_ChIP-Seq_THP-1_Human0.71744623
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.70985052
139* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69718894
140EWS_26573619_Chip-Seq_HEK293_Human0.68734442
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.67640283
142ELK1_22589737_ChIP-Seq_MCF10A_Human0.66322845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67044827
2MP0010094_abnormal_chromosome_stability4.27615562
3MP0003111_abnormal_nucleus_morphology3.96561115
4MP0008057_abnormal_DNA_replication3.77912199
5MP0008877_abnormal_DNA_methylation3.53295390
6MP0003077_abnormal_cell_cycle3.49418649
7MP0004957_abnormal_blastocyst_morpholog3.39015543
8MP0008058_abnormal_DNA_repair3.09419802
9MP0008007_abnormal_cellular_replicative2.78882148
10MP0002396_abnormal_hematopoietic_system2.51358026
11MP0008932_abnormal_embryonic_tissue2.49718701
12MP0003123_paternal_imprinting2.34677725
13MP0003787_abnormal_imprinting2.15271698
14MP0008995_early_reproductive_senescence2.12402676
15MP0001730_embryonic_growth_arrest2.08087939
16MP0010352_gastrointestinal_tract_polyps2.06441925
17MP0000350_abnormal_cell_proliferation2.04713075
18MP0004808_abnormal_hematopoietic_stem2.04671846
19MP0010307_abnormal_tumor_latency2.02359265
20MP0001835_abnormal_antigen_presentation2.02179899
21MP0003890_abnormal_embryonic-extraembry1.97649329
22MP0005076_abnormal_cell_differentiation1.89327600
23MP0004147_increased_porphyrin_level1.85947288
24MP0000372_irregular_coat_pigmentation1.85021557
25MP0001672_abnormal_embryogenesis/_devel1.74041997
26MP0005380_embryogenesis_phenotype1.74041997
27MP0009697_abnormal_copulation1.65189764
28MP0001697_abnormal_embryo_size1.62554201
29MP0005075_abnormal_melanosome_morpholog1.61994613
30MP0003984_embryonic_growth_retardation1.56995687
31MP0002210_abnormal_sex_determination1.56153446
32MP0006072_abnormal_retinal_apoptosis1.53955401
33MP0002088_abnormal_embryonic_growth/wei1.53166752
34MP0003786_premature_aging1.53104031
35MP0003806_abnormal_nucleotide_metabolis1.51090078
36MP0002085_abnormal_embryonic_tissue1.50859762
37MP0003121_genomic_imprinting1.50176634
38MP0003718_maternal_effect1.48413541
39MP0001293_anophthalmia1.47229262
40MP0006035_abnormal_mitochondrial_morpho1.43677936
41MP0002084_abnormal_developmental_patter1.42825869
42MP0000490_abnormal_crypts_of1.37529411
43MP0001929_abnormal_gametogenesis1.36719340
44MP0003950_abnormal_plasma_membrane1.35712816
45MP0006036_abnormal_mitochondrial_physio1.35608264
46* MP0002080_prenatal_lethality1.34054005
47MP0003195_calcinosis1.29207459
48MP0000313_abnormal_cell_death1.27037415
49MP0001145_abnormal_male_reproductive1.26893624
50MP0004197_abnormal_fetal_growth/weight/1.26696998
51MP0006292_abnormal_olfactory_placode1.25100802
52MP0003937_abnormal_limbs/digits/tail_de1.23875009
53MP0001800_abnormal_humoral_immune1.22487851
54MP0006276_abnormal_autonomic_nervous1.21627306
55MP0002086_abnormal_extraembryonic_tissu1.21510340
56MP0002019_abnormal_tumor_incidence1.21475066
57MP0001919_abnormal_reproductive_system1.21133343
58MP0001545_abnormal_hematopoietic_system1.19303908
59MP0005397_hematopoietic_system_phenotyp1.19303908
60MP0002102_abnormal_ear_morphology1.18320287
61MP0005410_abnormal_fertilization1.17818467
62MP0001873_stomach_inflammation1.17694507
63MP0000653_abnormal_sex_gland1.17670236
64MP0002006_tumorigenesis1.16309928
65MP0010030_abnormal_orbit_morphology1.15414912
66MP0009672_abnormal_birth_weight1.15289538
67MP0000703_abnormal_thymus_morphology1.14884739
68MP0005551_abnormal_eye_electrophysiolog1.14861801
69MP0004142_abnormal_muscle_tone1.14077661
70MP0009333_abnormal_splenocyte_physiolog1.09369233
71MP0001764_abnormal_homeostasis1.08645382
72MP0002277_abnormal_respiratory_mucosa1.08388746
73MP0009703_decreased_birth_body1.08245127
74MP0003315_abnormal_perineum_morphology1.05688687
75MP0000428_abnormal_craniofacial_morphol1.05090053
76MP0005253_abnormal_eye_physiology1.04379525
77MP0002398_abnormal_bone_marrow1.04129351
78MP0002166_altered_tumor_susceptibility1.02730975
79MP0002138_abnormal_hepatobiliary_system1.00881135
80MP0003567_abnormal_fetal_cardiomyocyte1.00102091
81MP0003303_peritoneal_inflammation0.99644812
82MP0000631_abnormal_neuroendocrine_gland0.97884299
83MP0001119_abnormal_female_reproductive0.97832323
84MP0000733_abnormal_muscle_development0.95957893
85MP0002420_abnormal_adaptive_immunity0.94218828
86MP0001986_abnormal_taste_sensitivity0.92837610
87MP0002938_white_spotting0.92759119
88MP0009053_abnormal_anal_canal0.92680356
89MP0005174_abnormal_tail_pigmentation0.92216712
90MP0003941_abnormal_skin_development0.92028037
91MP0002751_abnormal_autonomic_nervous0.91774220
92MP0001819_abnormal_immune_cell0.91193594
93MP0005395_other_phenotype0.89214901
94MP0003763_abnormal_thymus_physiology0.89093083
95MP0002722_abnormal_immune_system0.88022601
96MP0000647_abnormal_sebaceous_gland0.85660028
97MP0008872_abnormal_physiological_respon0.84788041
98MP0005084_abnormal_gallbladder_morpholo0.84773279
99MP0002723_abnormal_immune_serum0.84381719
100MP0003698_abnormal_male_reproductive0.84054087
101MP0000432_abnormal_head_morphology0.83869308
102MP0002160_abnormal_reproductive_system0.82983103
103MP0009278_abnormal_bone_marrow0.82486050
104MP0005621_abnormal_cell_physiology0.81945125
105MP0002452_abnormal_antigen_presenting0.81308549
106MP0003935_abnormal_craniofacial_develop0.80650298
107MP0002132_abnormal_respiratory_system0.80303049
108MP0005647_abnormal_sex_gland0.79485071
109MP0008961_abnormal_basal_metabolism0.77924139
110MP0005266_abnormal_metabolism0.77848377
111MP0000427_abnormal_hair_cycle0.77775836
112MP0000689_abnormal_spleen_morphology0.77561319
113MP0000383_abnormal_hair_follicle0.76215843
114MP0002111_abnormal_tail_morphology0.76165140
115MP0005645_abnormal_hypothalamus_physiol0.75722138
116MP0002092_abnormal_eye_morphology0.75249050
117MP0005646_abnormal_pituitary_gland0.75115341
118MP0005384_cellular_phenotype0.75031149
119MP0001286_abnormal_eye_development0.74678318
120MP0001188_hyperpigmentation0.74549258
121MP0008789_abnormal_olfactory_epithelium0.73438807
122MP0005671_abnormal_response_to0.73313980
123MP0000716_abnormal_immune_system0.73039101
124MP0002429_abnormal_blood_cell0.72945503
125MP0002163_abnormal_gland_morphology0.71759882
126MP0000569_abnormal_digit_pigmentation0.71686092
127MP0008260_abnormal_autophagy0.71251605
128MP0003115_abnormal_respiratory_system0.70918926
129MP0003755_abnormal_palate_morphology0.70340236
130MP0005367_renal/urinary_system_phenotyp0.70138380
131MP0000516_abnormal_urinary_system0.70138380
132MP0002095_abnormal_skin_pigmentation0.69944378
133MP0003448_altered_tumor_morphology0.68348214
134MP0003186_abnormal_redox_activity0.67664657
135MP0003943_abnormal_hepatobiliary_system0.67459482
136MP0003699_abnormal_female_reproductive0.67432661
137MP0002161_abnormal_fertility/fecundity0.66961549
138MP0002234_abnormal_pharynx_morphology0.66877525
139MP0000627_abnormal_mammary_gland0.66041734
140MP0005389_reproductive_system_phenotype0.65688969
141MP0003119_abnormal_digestive_system0.65351419
142MP0002177_abnormal_outer_ear0.64961656
143MP0001915_intracranial_hemorrhage0.64381336
144MP0000537_abnormal_urethra_morphology0.64136031
145MP0003861_abnormal_nervous_system0.64024164
146MP0003938_abnormal_ear_development0.63090491
147MP0002075_abnormal_coat/hair_pigmentati0.62467284
148MP0005187_abnormal_penis_morphology0.62354277

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.44431971
2Chromsome breakage (HP:0040012)3.64420851
3Patellar aplasia (HP:0006443)3.32475333
4Acute necrotizing encephalopathy (HP:0006965)3.30331039
5Pancreatic cysts (HP:0001737)3.29742530
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28614531
7Aplasia/Hypoplasia of the patella (HP:0006498)3.14166623
8Increased CSF lactate (HP:0002490)3.11402656
9Mitochondrial inheritance (HP:0001427)3.08517343
10Impulsivity (HP:0100710)3.08184493
11Acute encephalopathy (HP:0006846)3.00295520
12Increased nuchal translucency (HP:0010880)2.95192545
13Ectopic kidney (HP:0000086)2.93255012
14Abnormal mitochondria in muscle tissue (HP:0008316)2.93104209
15Pancreatic fibrosis (HP:0100732)2.85494913
16Increased hepatocellular lipid droplets (HP:0006565)2.85257891
17Colon cancer (HP:0003003)2.83488378
18Progressive macrocephaly (HP:0004481)2.80599551
19Molar tooth sign on MRI (HP:0002419)2.77542097
20Abnormality of midbrain morphology (HP:0002418)2.77542097
21Short 4th metacarpal (HP:0010044)2.77437080
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77437080
23Meckel diverticulum (HP:0002245)2.77268155
24Hepatocellular necrosis (HP:0001404)2.76840846
25Facial hemangioma (HP:0000329)2.76835735
26Abnormality of chromosome stability (HP:0003220)2.76523903
27Volvulus (HP:0002580)2.74416149
28Breast hypoplasia (HP:0003187)2.69954230
29True hermaphroditism (HP:0010459)2.67767237
303-Methylglutaconic aciduria (HP:0003535)2.67440466
31Lipid accumulation in hepatocytes (HP:0006561)2.64906776
32Abnormality of the anterior horn cell (HP:0006802)2.64220278
33Degeneration of anterior horn cells (HP:0002398)2.64220278
34Abnormality of the ileum (HP:0001549)2.61096307
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.57282673
36Hepatic necrosis (HP:0002605)2.54492633
37Medulloblastoma (HP:0002885)2.51794646
38Abnormality of the preputium (HP:0100587)2.48532557
39Abnormal biliary tract physiology (HP:0012439)2.48332164
40Bile duct proliferation (HP:0001408)2.48332164
41Panhypogammaglobulinemia (HP:0003139)2.47853606
42IgG deficiency (HP:0004315)2.41500038
43Increased serum lactate (HP:0002151)2.39840840
44Renal cortical cysts (HP:0000803)2.39828344
45Abnormal spermatogenesis (HP:0008669)2.39309541
46Proximal placement of thumb (HP:0009623)2.36793082
47Acute myeloid leukemia (HP:0004808)2.34737204
48Deviation of the thumb (HP:0009603)2.31512450
49Myelodysplasia (HP:0002863)2.31356807
50Cerebral edema (HP:0002181)2.30315563
51Abnormality of the pons (HP:0007361)2.29311235
52Medial flaring of the eyebrow (HP:0010747)2.28500831
53Atresia of the external auditory canal (HP:0000413)2.28041596
54Duodenal stenosis (HP:0100867)2.27638450
55Small intestinal stenosis (HP:0012848)2.27638450
56Cleft eyelid (HP:0000625)2.27465566
57Premature graying of hair (HP:0002216)2.26608275
58Short middle phalanx of the 5th finger (HP:0004220)2.26312780
59Rough bone trabeculation (HP:0100670)2.24953957
60Abnormal lung lobation (HP:0002101)2.24582958
61Abnormality of the carotid arteries (HP:0005344)2.22295159
62Selective tooth agenesis (HP:0001592)2.21467001
63Oligodactyly (HP:0012165)2.20665717
64Absent radius (HP:0003974)2.20646513
65Oral leukoplakia (HP:0002745)2.20598474
66Microglossia (HP:0000171)2.20170700
67Severe combined immunodeficiency (HP:0004430)2.19121841
68Tracheoesophageal fistula (HP:0002575)2.18714464
69Abnormal number of erythroid precursors (HP:0012131)2.18619495
70Congenital stationary night blindness (HP:0007642)2.18002145
71Lactic acidosis (HP:0003128)2.16721014
72Long eyelashes (HP:0000527)2.16708391
73Abnormality of the prostate (HP:0008775)2.16265927
74Overlapping toe (HP:0001845)2.16246157
75Abnormality of the labia minora (HP:0012880)2.16081180
76Renal Fanconi syndrome (HP:0001994)2.08990706
77Capillary hemangiomas (HP:0005306)2.08830623
78Abnormality of the renal cortex (HP:0011035)2.08610302
79Bone marrow hypocellularity (HP:0005528)2.07911311
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.05970416
81Sloping forehead (HP:0000340)2.05864222
82Short thumb (HP:0009778)2.05236598
83Chronic hepatic failure (HP:0100626)2.05129462
84Hypoplasia of the pons (HP:0012110)2.03859991
85Entropion (HP:0000621)2.02635271
86Aplasia involving forearm bones (HP:0009822)2.02603888
87Absent forearm bone (HP:0003953)2.02603888
88Neoplasm of the pancreas (HP:0002894)2.02354504
89Microvesicular hepatic steatosis (HP:0001414)2.01536092
90Abnormality of cells of the erythroid lineage (HP:0012130)2.01408529
91Type I transferrin isoform profile (HP:0003642)2.01406357
92Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99632322
93Carpal bone hypoplasia (HP:0001498)1.99606785
94Renal duplication (HP:0000075)1.99239163
95Prominent nose (HP:0000448)1.98442769
96Deep philtrum (HP:0002002)1.96732995
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96281867
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96281867
99Abnormality of B cell number (HP:0010975)1.96182727
100Absent thumb (HP:0009777)1.96095318
101Pelvic girdle muscle weakness (HP:0003749)1.95483317
102Pancytopenia (HP:0001876)1.93659120
103Microtia (HP:0008551)1.92808316
104Supernumerary spleens (HP:0009799)1.92557108
105Cellular immunodeficiency (HP:0005374)1.91881650
106Increased number of teeth (HP:0011069)1.89000311
107Optic disc pallor (HP:0000543)1.88480052
108Hypothermia (HP:0002045)1.88343117
109Aplastic anemia (HP:0001915)1.88107423
110Trigonocephaly (HP:0000243)1.87627116
111Aplasia/Hypoplasia of the sternum (HP:0006714)1.86134010
112Spinal cord lesions (HP:0100561)1.85133735
113Syringomyelia (HP:0003396)1.85133735
114T lymphocytopenia (HP:0005403)1.85099372
115Congenital primary aphakia (HP:0007707)1.85044425
116Abnormality of T cell number (HP:0011839)1.84416300
117Abnormality of the renal collecting system (HP:0004742)1.83275187
118Increased intramyocellular lipid droplets (HP:0012240)1.82213145
119Abnormality of the duodenum (HP:0002246)1.81400518
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80431556
121Abnormal protein N-linked glycosylation (HP:0012347)1.80431556
122Abnormal protein glycosylation (HP:0012346)1.80431556
123Abnormal glycosylation (HP:0012345)1.80431556
124Thyroiditis (HP:0100646)1.80006743
125Combined immunodeficiency (HP:0005387)1.79868037
126Abnormality of alanine metabolism (HP:0010916)1.79861314
127Hyperalaninemia (HP:0003348)1.79861314
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79861314
129Agnosia (HP:0010524)1.78647058
130Short tibia (HP:0005736)1.78440254
131Duplicated collecting system (HP:0000081)1.77878756
132Blepharitis (HP:0000498)1.77677118
133Rhabdomyosarcoma (HP:0002859)1.77399666
134Nephronophthisis (HP:0000090)1.77158897
135Exertional dyspnea (HP:0002875)1.76849603
136Horseshoe kidney (HP:0000085)1.76439665
137B lymphocytopenia (HP:0010976)1.76228618
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.75507977
139Abnormal number of incisors (HP:0011064)1.74961386
140Limb hypertonia (HP:0002509)1.73264340
141Abnormal delayed hypersensitivity skin test (HP:0002963)1.73027591
142Breast aplasia (HP:0100783)1.73026279
143Type II lissencephaly (HP:0007260)1.72636115
144IgM deficiency (HP:0002850)1.72511868
145Methylmalonic acidemia (HP:0002912)1.71559570
146Clubbing of toes (HP:0100760)1.71330471
147Triphalangeal thumb (HP:0001199)1.71279071
148Cutis marmorata (HP:0000965)1.70855256
149Optic nerve coloboma (HP:0000588)1.70148967
150Gait imbalance (HP:0002141)1.69902389
151Nephrogenic diabetes insipidus (HP:0009806)1.69858356
152Male pseudohermaphroditism (HP:0000037)1.69286310
153Abnormality of T cells (HP:0002843)1.68304705
154Abnormality of the 4th metacarpal (HP:0010012)1.68154298
155Chronic mucocutaneous candidiasis (HP:0002728)1.67740121
156Recurrent cutaneous fungal infections (HP:0011370)1.67740121
157Congenital, generalized hypertrichosis (HP:0004540)1.67335787
158Constricted visual fields (HP:0001133)1.66960360
159Nephroblastoma (Wilms tumor) (HP:0002667)1.66646480
160Abnormality of methionine metabolism (HP:0010901)1.66509605
161Embryonal renal neoplasm (HP:0011794)1.65814639
162Abnormal trabecular bone morphology (HP:0100671)1.65807273
163Azoospermia (HP:0000027)1.65640794
164Slender long bone (HP:0003100)1.64200716
165Papillary thyroid carcinoma (HP:0002895)1.63384219
166Aplasia/Hypoplasia of the breasts (HP:0010311)1.62637620
167Reticulocytopenia (HP:0001896)1.62282717
168Oligodactyly (hands) (HP:0001180)1.61690964
169High pitched voice (HP:0001620)1.61318673
170Squamous cell carcinoma (HP:0002860)1.60970212
171Abnormality of DNA repair (HP:0003254)1.60882568
172Cerebral hypomyelination (HP:0006808)1.60024476
173Abnormality of the hip-girdle musculature (HP:0001445)1.60014513
174Abnormality of the musculature of the pelvis (HP:0001469)1.60014513
175Abnormality of the fingertips (HP:0001211)1.59546186
176Basal cell carcinoma (HP:0002671)1.58763985
177Lymphoma (HP:0002665)1.58103224
178Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57413143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.69841353
2BUB13.88733459
3WEE13.55752360
4MST43.34377092
5FRK3.10213066
6PLK42.99203479
7NEK22.93070394
8BRSK22.74729598
9EIF2AK12.69034026
10MKNK12.62313672
11SRPK12.53293357
12VRK22.47473047
13ACVR1B2.44998206
14MKNK22.40502720
15TXK2.24621218
16TTK2.21321907
17CDK122.08465872
18PLK12.03531936
19RPS6KA42.02327501
20PLK31.95508141
21MAP4K21.88160384
22BRD41.83827338
23ATR1.78998809
24TESK21.76252912
25TSSK61.75033835
26TAOK31.73544417
27CHEK21.69646990
28CDK191.65547523
29SCYL21.64680487
30BRSK11.63779401
31DYRK31.63043771
32CDK71.62453132
33EIF2AK31.56857001
34STK31.51994098
35* AURKB1.50009275
36CDK41.43422709
37ZAK1.42579693
38WNK31.41797944
39MELK1.36806548
40CHEK11.36437667
41STK101.34502626
42LATS11.30972471
43STK161.30014515
44TAF11.27653327
45TRIM281.25227331
46ERBB31.23355213
47VRK11.19300777
48PIM21.13833893
49MAP3K121.12840882
50CDK61.11439702
51BMPR21.10285143
52STK41.08660443
53MAP3K81.08404433
54PBK1.01187472
55MAPK131.00600403
56ATM0.97830347
57ITK0.95704447
58ADRBK20.93952367
59FLT30.92951090
60NUAK10.92815659
61CDK20.91430644
62LATS20.91153414
63PIM10.90655211
64AURKA0.89229598
65CDK80.88375476
66INSRR0.87356653
67MAP3K40.86730943
68NEK10.85505732
69CCNB10.83623296
70ALK0.82951836
71EIF2AK20.80434508
72NME10.79933571
73IRAK40.79297743
74STK38L0.78629303
75GRK10.78307368
76EEF2K0.77304078
77PASK0.77300416
78OXSR10.76805190
79BRAF0.75913306
80NME20.75459100
81PDK20.75110463
82NLK0.75085507
83PNCK0.74530457
84YES10.73308357
85CDK10.73148040
86NEK90.72716356
87TLK10.70661792
88TGFBR10.66473405
89CHUK0.65505481
90TESK10.64694474
91MAP3K50.64104691
92TNIK0.64079314
93CDK90.63770007
94KDR0.63444614
95AKT30.63355218
96BLK0.60822253
97MAP3K100.60532652
98BCR0.58371302
99SYK0.56531144
100TEC0.56178792
101CSNK1A1L0.53929026
102RPS6KA50.53586584
103PAK40.52861797
104KIT0.51130958
105MTOR0.51046419
106PAK10.50942756
107CSNK2A20.49976298
108CSNK2A10.49644025
109PRKCQ0.49426828
110PLK20.48062042
111CSNK1G10.47981013
112RPS6KB20.46481106
113CSNK1G30.45685075
114CDK30.45010303
115BMPR1B0.43522230
116STK390.43068360
117LYN0.42326928
118IRAK10.42128519
119BCKDK0.41768703
120CLK10.41673970
121DYRK20.41276496
122MAP4K10.40912766
123LRRK20.40448579
124TAOK20.40257119
125CAMKK20.39682291
126LCK0.38624610
127FGFR10.38355654
128WNK40.38117665
129IKBKE0.38058434
130PIK3CG0.36132965
131MAPKAPK50.35166258
132PRKCI0.34470021
133BTK0.32594467
134PDK30.32290973
135PDK40.32290973
136MAPK140.31364119
137MARK30.30610815
138CSNK1E0.29618511
139SIK30.29606949
140JAK30.26550341
141IKBKB0.26219247
142PRKDC0.26121998
143CSNK1G20.25846015
144DMPK0.24589145

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.92724047
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73865946
3Mismatch repair_Homo sapiens_hsa034303.18963128
4RNA transport_Homo sapiens_hsa030133.17200420
5Cell cycle_Homo sapiens_hsa041103.13869288
6Spliceosome_Homo sapiens_hsa030402.93119479
7Homologous recombination_Homo sapiens_hsa034402.91384316
8RNA polymerase_Homo sapiens_hsa030202.86713235
9Oxidative phosphorylation_Homo sapiens_hsa001902.76860474
10Base excision repair_Homo sapiens_hsa034102.62452957
11Parkinsons disease_Homo sapiens_hsa050122.43106896
12Fanconi anemia pathway_Homo sapiens_hsa034602.38313836
13Basal transcription factors_Homo sapiens_hsa030222.29927642
14Nucleotide excision repair_Homo sapiens_hsa034202.24965800
15Proteasome_Homo sapiens_hsa030502.12583598
16mRNA surveillance pathway_Homo sapiens_hsa030152.09751766
17Non-homologous end-joining_Homo sapiens_hsa034501.87864223
18Pyrimidine metabolism_Homo sapiens_hsa002401.87202549
19RNA degradation_Homo sapiens_hsa030181.86176665
20p53 signaling pathway_Homo sapiens_hsa041151.86111704
21One carbon pool by folate_Homo sapiens_hsa006701.75922301
22Huntingtons disease_Homo sapiens_hsa050161.74075520
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58502273
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54472550
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53358912
26Vitamin B6 metabolism_Homo sapiens_hsa007501.50333024
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39030727
28Epstein-Barr virus infection_Homo sapiens_hsa051691.38972304
29Alzheimers disease_Homo sapiens_hsa050101.38760534
30Propanoate metabolism_Homo sapiens_hsa006401.38576317
31Ribosome_Homo sapiens_hsa030101.37864778
32Herpes simplex infection_Homo sapiens_hsa051681.31690084
33Oocyte meiosis_Homo sapiens_hsa041141.30333185
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22136356
35MicroRNAs in cancer_Homo sapiens_hsa052061.19462839
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15760477
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14835404
38Purine metabolism_Homo sapiens_hsa002301.14631525
39Viral carcinogenesis_Homo sapiens_hsa052031.09314810
40Fatty acid elongation_Homo sapiens_hsa000621.08263750
41HTLV-I infection_Homo sapiens_hsa051661.03279680
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03222284
43Butanoate metabolism_Homo sapiens_hsa006501.01568872
44Antigen processing and presentation_Homo sapiens_hsa046120.98092761
45Type I diabetes mellitus_Homo sapiens_hsa049400.96946307
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91719773
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90819412
48Measles_Homo sapiens_hsa051620.89234919
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88484604
50Small cell lung cancer_Homo sapiens_hsa052220.87106020
51Chronic myeloid leukemia_Homo sapiens_hsa052200.86994166
52Nitrogen metabolism_Homo sapiens_hsa009100.86934190
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.83650889
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83544927
55Systemic lupus erythematosus_Homo sapiens_hsa053220.82672205
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82223078
57Tryptophan metabolism_Homo sapiens_hsa003800.82181504
58Thyroid cancer_Homo sapiens_hsa052160.81106114
59Phototransduction_Homo sapiens_hsa047440.77402398
60Hepatitis B_Homo sapiens_hsa051610.76685690
61Shigellosis_Homo sapiens_hsa051310.76038293
62Colorectal cancer_Homo sapiens_hsa052100.74983511
63TGF-beta signaling pathway_Homo sapiens_hsa043500.71671368
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70056862
65Pentose phosphate pathway_Homo sapiens_hsa000300.69398387
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67727637
67Leishmaniasis_Homo sapiens_hsa051400.66476516
68Viral myocarditis_Homo sapiens_hsa054160.66399841
69Adherens junction_Homo sapiens_hsa045200.66387401
70Hippo signaling pathway_Homo sapiens_hsa043900.66309592
71Legionellosis_Homo sapiens_hsa051340.65879691
72Primary immunodeficiency_Homo sapiens_hsa053400.64349934
73Regulation of autophagy_Homo sapiens_hsa041400.62014012
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.61709159
75Hedgehog signaling pathway_Homo sapiens_hsa043400.59938476
76Basal cell carcinoma_Homo sapiens_hsa052170.59085466
77Apoptosis_Homo sapiens_hsa042100.59049380
78Olfactory transduction_Homo sapiens_hsa047400.58425472
79Prostate cancer_Homo sapiens_hsa052150.58128920
80Influenza A_Homo sapiens_hsa051640.56801707
81Peroxisome_Homo sapiens_hsa041460.56741921
82Notch signaling pathway_Homo sapiens_hsa043300.56211732
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.55671141
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.54178710
85Pancreatic cancer_Homo sapiens_hsa052120.53726351
86Pathways in cancer_Homo sapiens_hsa052000.53474014
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53310772
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52263070
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52051636
90FoxO signaling pathway_Homo sapiens_hsa040680.51759637
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51188064
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50842966
93Non-small cell lung cancer_Homo sapiens_hsa052230.50253385
94Rheumatoid arthritis_Homo sapiens_hsa053230.50206986
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50016390
96Metabolic pathways_Homo sapiens_hsa011000.49738842
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49431299
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48958532
99Allograft rejection_Homo sapiens_hsa053300.48633747
100Pyruvate metabolism_Homo sapiens_hsa006200.48576143
101mTOR signaling pathway_Homo sapiens_hsa041500.48299283
102Cardiac muscle contraction_Homo sapiens_hsa042600.46136640
103T cell receptor signaling pathway_Homo sapiens_hsa046600.46026754
104Sulfur metabolism_Homo sapiens_hsa009200.45626435
105Linoleic acid metabolism_Homo sapiens_hsa005910.45160530
106Collecting duct acid secretion_Homo sapiens_hsa049660.44703902
107Acute myeloid leukemia_Homo sapiens_hsa052210.44568681
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.43902978
109Wnt signaling pathway_Homo sapiens_hsa043100.42678584
110Endometrial cancer_Homo sapiens_hsa052130.42651636
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42067170
112Toxoplasmosis_Homo sapiens_hsa051450.41020672
113Hematopoietic cell lineage_Homo sapiens_hsa046400.40822250
114B cell receptor signaling pathway_Homo sapiens_hsa046620.40298865
115Ether lipid metabolism_Homo sapiens_hsa005650.40235810
116HIF-1 signaling pathway_Homo sapiens_hsa040660.40093786
117Asthma_Homo sapiens_hsa053100.39681517
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39281241
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38827139
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38429306
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38101452
122TNF signaling pathway_Homo sapiens_hsa046680.37086418
123Melanoma_Homo sapiens_hsa052180.37018358
124Taste transduction_Homo sapiens_hsa047420.36836740
125Glutathione metabolism_Homo sapiens_hsa004800.35627144
126Graft-versus-host disease_Homo sapiens_hsa053320.35574080
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.35130640
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34963676
129Proteoglycans in cancer_Homo sapiens_hsa052050.33652149
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.32483182
131Osteoclast differentiation_Homo sapiens_hsa043800.31414953
132Bladder cancer_Homo sapiens_hsa052190.31130899
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29190543
134Alcoholism_Homo sapiens_hsa050340.28928845
135Protein export_Homo sapiens_hsa030600.28320805
136Prolactin signaling pathway_Homo sapiens_hsa049170.27792602
137Renal cell carcinoma_Homo sapiens_hsa052110.27553920
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27110272
139Chemical carcinogenesis_Homo sapiens_hsa052040.26647880
140Caffeine metabolism_Homo sapiens_hsa002320.26641317
141Autoimmune thyroid disease_Homo sapiens_hsa053200.26579287
142Fatty acid metabolism_Homo sapiens_hsa012120.25939811
143Selenocompound metabolism_Homo sapiens_hsa004500.25738058
144Folate biosynthesis_Homo sapiens_hsa007900.23375646
145N-Glycan biosynthesis_Homo sapiens_hsa005100.23237561
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18769577
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18210279
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.18055806
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17386488
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.17324791

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