PPIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.23313174
2translational termination (GO:0006415)6.07592374
3ribosomal small subunit assembly (GO:0000028)5.98710007
4ribosomal small subunit biogenesis (GO:0042274)5.80137751
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.72707612
6maturation of SSU-rRNA (GO:0030490)5.39998341
7translational elongation (GO:0006414)5.38212296
8ATP synthesis coupled proton transport (GO:0015986)5.32339505
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.32339505
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.28917753
11cotranslational protein targeting to membrane (GO:0006613)5.24859717
12protein targeting to ER (GO:0045047)5.18642247
13cellular protein complex disassembly (GO:0043624)4.95715960
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.93170898
15protein localization to endoplasmic reticulum (GO:0070972)4.90247237
16translational initiation (GO:0006413)4.89289935
17ribosomal large subunit biogenesis (GO:0042273)4.80343753
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.79532847
19* viral life cycle (GO:0019058)4.74710820
20DNA strand elongation involved in DNA replication (GO:0006271)4.63084598
21DNA deamination (GO:0045006)4.54886397
22telomere maintenance via semi-conservative replication (GO:0032201)4.46365659
23DNA strand elongation (GO:0022616)4.37580310
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.33654778
25protein complex disassembly (GO:0043241)4.33327480
26proteasome assembly (GO:0043248)4.22896563
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21946544
28mitotic sister chromatid segregation (GO:0000070)4.19693167
29formation of translation preinitiation complex (GO:0001731)4.18821615
30DNA unwinding involved in DNA replication (GO:0006268)4.16834523
31translation (GO:0006412)4.16553743
32mitotic chromosome condensation (GO:0007076)4.13822550
33ribonucleoprotein complex biogenesis (GO:0022613)4.13529512
34DNA replication initiation (GO:0006270)4.12659302
35macromolecular complex disassembly (GO:0032984)4.12458507
36mitotic metaphase plate congression (GO:0007080)4.06274583
37spliceosomal snRNP assembly (GO:0000387)3.98946348
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91558159
39negative regulation of ligase activity (GO:0051352)3.90673421
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90673421
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.88422692
42telomere maintenance via recombination (GO:0000722)3.88111710
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87570217
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.87289110
45* establishment of integrated proviral latency (GO:0075713)3.82438317
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81378779
47sister chromatid segregation (GO:0000819)3.80777930
48protein localization to chromosome, centromeric region (GO:0071459)3.79845993
49protein localization to kinetochore (GO:0034501)3.78174046
50spliceosomal complex assembly (GO:0000245)3.70934255
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.66586799
52rRNA processing (GO:0006364)3.66474038
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.66425495
54mitotic recombination (GO:0006312)3.63855717
55nuclear pore complex assembly (GO:0051292)3.63436891
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.61289929
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.61289929
58cullin deneddylation (GO:0010388)3.61258708
59regulation of cellular amino acid metabolic process (GO:0006521)3.60832172
60chaperone-mediated protein transport (GO:0072321)3.59549408
61CENP-A containing nucleosome assembly (GO:0034080)3.58510443
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56487373
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56487373
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56487373
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.55537000
66termination of RNA polymerase III transcription (GO:0006386)3.55537000
67cellular component biogenesis (GO:0044085)3.53806609
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.52492430
69rRNA metabolic process (GO:0016072)3.51897668
70GTP biosynthetic process (GO:0006183)3.50688220
71signal transduction involved in DNA integrity checkpoint (GO:0072401)3.50501114
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.50501114
73chromatin remodeling at centromere (GO:0031055)3.49511406
74nucleobase biosynthetic process (GO:0046112)3.48717335
75UTP biosynthetic process (GO:0006228)3.48153369
76telomere maintenance via telomere lengthening (GO:0010833)3.45643183
77protein targeting to membrane (GO:0006612)3.44840542
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.44817332
79regulation of translational fidelity (GO:0006450)3.44124365
80mRNA catabolic process (GO:0006402)3.43677128
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.42626793
82transcription-coupled nucleotide-excision repair (GO:0006283)3.42324540
83purine nucleobase biosynthetic process (GO:0009113)3.41304142
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41084413
85respiratory electron transport chain (GO:0022904)3.40590452
86protein deneddylation (GO:0000338)3.39837964
87* establishment of viral latency (GO:0019043)3.39689657
88ribosome assembly (GO:0042255)3.39039986
89metaphase plate congression (GO:0051310)3.38405510
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38380672
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37606206
927-methylguanosine mRNA capping (GO:0006370)3.37436523
93DNA replication-dependent nucleosome organization (GO:0034723)3.36390695
94DNA replication-dependent nucleosome assembly (GO:0006335)3.36390695
95DNA replication checkpoint (GO:0000076)3.35572340
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35344306
97protein maturation by protein folding (GO:0022417)3.34958550
98deoxyribonucleotide biosynthetic process (GO:0009263)3.34846741
99pseudouridine synthesis (GO:0001522)3.33717929
1007-methylguanosine RNA capping (GO:0009452)3.33233287
101RNA capping (GO:0036260)3.33233287
102electron transport chain (GO:0022900)3.32815398
103nucleobase-containing small molecule interconversion (GO:0015949)3.31374416
104DNA ligation (GO:0006266)3.30838360
105ribosome biogenesis (GO:0042254)3.27829544
106mitotic nuclear envelope disassembly (GO:0007077)3.27356109
107establishment of protein localization to mitochondrion (GO:0072655)3.26551789
108RNA catabolic process (GO:0006401)3.26384816
109nuclear pore organization (GO:0006999)3.24723691
110cell cycle G1/S phase transition (GO:0044843)3.24444506
111G1/S transition of mitotic cell cycle (GO:0000082)3.24444506
112positive regulation of ligase activity (GO:0051351)3.21735181
113regulation of mitotic spindle organization (GO:0060236)3.21477381
114regulation of mitochondrial translation (GO:0070129)3.18665103
115protein neddylation (GO:0045116)3.18095055
116pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18083173
117antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16670893
118folic acid-containing compound biosynthetic process (GO:0009396)3.13916291
119regulation of spindle organization (GO:0090224)3.12440527
120regulation of ubiquitin-protein transferase activity (GO:0051438)3.10669756
121protein complex localization (GO:0031503)3.06940955
122mitotic nuclear envelope reassembly (GO:0007084)3.05826591
123nuclear envelope reassembly (GO:0031468)3.05826591
124tRNA aminoacylation for protein translation (GO:0006418)3.04397082
125L-serine metabolic process (GO:0006563)3.04255881
126IMP biosynthetic process (GO:0006188)3.03757294
127nuclear envelope disassembly (GO:0051081)3.01536575
128membrane disassembly (GO:0030397)3.01536575
129oxidative phosphorylation (GO:0006119)2.99796092
130regulation of ligase activity (GO:0051340)2.98421946
131COPI coating of Golgi vesicle (GO:0048205)2.97925572
132Golgi transport vesicle coating (GO:0048200)2.97925572
133tRNA aminoacylation (GO:0043039)2.97855958
134amino acid activation (GO:0043038)2.97855958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.11361914
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.95181065
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.39387697
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13844569
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.94835365
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.86598001
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.49521265
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47254189
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45322005
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44647250
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.39093519
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.33717475
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.25399536
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19279031
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.10540042
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96829533
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.96162844
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.85034202
19* XRN2_22483619_ChIP-Seq_HELA_Human2.82047308
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66599600
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58486764
22VDR_23849224_ChIP-Seq_CD4+_Human2.53705303
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47857996
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38072366
25* DCP1A_22483619_ChIP-Seq_HELA_Human2.34893476
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34752041
27TTF2_22483619_ChIP-Seq_HELA_Human2.28505207
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28270531
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24278409
30FOXP3_21729870_ChIP-Seq_TREG_Human2.14910915
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09739299
32ELK1_19687146_ChIP-ChIP_HELA_Human2.09603100
33GABP_19822575_ChIP-Seq_HepG2_Human2.00499786
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93086582
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92905536
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.88144884
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87604888
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81739049
39ZNF263_19887448_ChIP-Seq_K562_Human1.80544267
40AR_21909140_ChIP-Seq_LNCAP_Human1.72936114
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.71701917
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71200804
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69472891
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67738321
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67479533
46* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66740413
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66462370
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65889671
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64654908
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62131696
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.59577158
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56512006
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54499169
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46670636
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43769902
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.40049392
57* CIITA_25753668_ChIP-Seq_RAJI_Human1.37638135
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33041271
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31816433
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31189850
61* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30501053
62MYC_18940864_ChIP-ChIP_HL60_Human1.29711190
63* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29301427
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27928931
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25513926
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24870996
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22816803
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.20213051
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19858087
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16742879
71KDM5A_27292631_Chip-Seq_BREAST_Human1.16584578
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15330893
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15163492
74* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14770311
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11381111
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10657920
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08084035
78* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07977484
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05981259
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05632722
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04029279
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03015487
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02582464
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99761863
85* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98323633
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98145047
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97484256
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96220365
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96207551
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95067322
91OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94984331
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93808592
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91664605
94SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91089836
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90371470
96TFEB_21752829_ChIP-Seq_HELA_Human0.90336901
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90000856
98* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89557493
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89226284
100* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88478445
101* MYC_22102868_ChIP-Seq_BL_Human0.88077346
102* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87681950
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86905399
104* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86314019
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84254580
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82167411
107SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81848118
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77595340
109* SOX17_20123909_ChIP-Seq_XEN_Mouse0.77262618
110IRF1_19129219_ChIP-ChIP_H3396_Human0.76780791
111* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75035645
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.73910841
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.73376098
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73178003
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.72790334
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72427196

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.46606805
2MP0004957_abnormal_blastocyst_morpholog4.82434755
3MP0010094_abnormal_chromosome_stability4.36604179
4MP0009379_abnormal_foot_pigmentation4.27633765
5MP0003077_abnormal_cell_cycle3.89753974
6MP0003111_abnormal_nucleus_morphology3.79372274
7MP0008057_abnormal_DNA_replication3.50220761
8MP0008932_abnormal_embryonic_tissue3.25333297
9MP0008058_abnormal_DNA_repair3.00403268
10MP0003123_paternal_imprinting2.80857085
11MP0008007_abnormal_cellular_replicative2.66257830
12MP0001529_abnormal_vocalization2.57206838
13MP0002877_abnormal_melanocyte_morpholog2.42531249
14MP0009697_abnormal_copulation2.22130960
15MP0001730_embryonic_growth_arrest2.11317452
16MP0003941_abnormal_skin_development2.09762556
17MP0003786_premature_aging1.97053940
18MP0000350_abnormal_cell_proliferation1.96191023
19MP0010234_abnormal_vibrissa_follicle1.80736498
20MP0008877_abnormal_DNA_methylation1.75665644
21MP0005501_abnormal_skin_physiology1.73587855
22MP0004133_heterotaxia1.73127761
23MP0006035_abnormal_mitochondrial_morpho1.64441243
24MP0003880_abnormal_central_pattern1.64001419
25MP0001905_abnormal_dopamine_level1.61792429
26MP0003806_abnormal_nucleotide_metabolis1.61698253
27MP0006292_abnormal_olfactory_placode1.60499306
28MP0001346_abnormal_lacrimal_gland1.55675739
29MP0003718_maternal_effect1.54206438
30MP0004233_abnormal_muscle_weight1.50934416
31MP0002396_abnormal_hematopoietic_system1.50312232
32MP0006036_abnormal_mitochondrial_physio1.50152499
33MP0001697_abnormal_embryo_size1.48422637
34MP0003186_abnormal_redox_activity1.43783318
35MP0002796_impaired_skin_barrier1.42892091
36MP0003121_genomic_imprinting1.41921724
37MP0003315_abnormal_perineum_morphology1.38984326
38* MP0002080_prenatal_lethality1.38012879
39MP0000358_abnormal_cell_content/1.36794640
40MP0000313_abnormal_cell_death1.35748496
41MP0002160_abnormal_reproductive_system1.34069825
42MP0003890_abnormal_embryonic-extraembry1.31152943
43MP0009672_abnormal_birth_weight1.29728485
44MP0002736_abnormal_nociception_after1.27537105
45MP0005408_hypopigmentation1.26113225
46MP0000490_abnormal_crypts_of1.24285025
47MP0002938_white_spotting1.22967004
48MP0001881_abnormal_mammary_gland1.22550049
49MP0003705_abnormal_hypodermis_morpholog1.20257142
50MP0006276_abnormal_autonomic_nervous1.17993546
51MP0002019_abnormal_tumor_incidence1.17930440
52MP0002085_abnormal_embryonic_tissue1.17571698
53MP0010030_abnormal_orbit_morphology1.15829590
54MP0002102_abnormal_ear_morphology1.15170930
55MP0005623_abnormal_meninges_morphology1.15111149
56MP0000537_abnormal_urethra_morphology1.13600512
57MP0002751_abnormal_autonomic_nervous1.12795702
58MP0009333_abnormal_splenocyte_physiolog1.11626966
59MP0001672_abnormal_embryogenesis/_devel1.08718853
60MP0005380_embryogenesis_phenotype1.08718853
61MP0001968_abnormal_touch/_nociception1.05352887
62MP0001727_abnormal_embryo_implantation1.03921678
63MP0002697_abnormal_eye_size1.02506879
64MP0001986_abnormal_taste_sensitivity1.01787504
65MP0002084_abnormal_developmental_patter1.01018251
66MP0008789_abnormal_olfactory_epithelium1.00913454
67MP0000703_abnormal_thymus_morphology1.00802014
68MP0004808_abnormal_hematopoietic_stem0.99999802
69MP0000579_abnormal_nail_morphology0.99862431
70MP0003122_maternal_imprinting0.99238156
71MP0000627_abnormal_mammary_gland0.99100108
72MP0003567_abnormal_fetal_cardiomyocyte0.98498735
73MP0002163_abnormal_gland_morphology0.97931993
74MP0006054_spinal_hemorrhage0.97565894
75MP0003566_abnormal_cell_adhesion0.96103252
76MP0002638_abnormal_pupillary_reflex0.95477868
77MP0005389_reproductive_system_phenotype0.95299728
78MP0000762_abnormal_tongue_morphology0.92570699
79MP0010352_gastrointestinal_tract_polyps0.92256177
80MP0000647_abnormal_sebaceous_gland0.90688286
81MP0003984_embryonic_growth_retardation0.89155473
82MP0001188_hyperpigmentation0.88057060
83MP0002088_abnormal_embryonic_growth/wei0.85516354
84MP0004185_abnormal_adipocyte_glucose0.85193142
85MP0002210_abnormal_sex_determination0.84458202
86MP0001145_abnormal_male_reproductive0.82504554
87MP0005621_abnormal_cell_physiology0.81927959
88MP0000372_irregular_coat_pigmentation0.81746140
89MP0003763_abnormal_thymus_physiology0.81519378
90MP0000858_altered_metastatic_potential0.81513340
91MP0002060_abnormal_skin_morphology0.78876371
92MP0001293_anophthalmia0.78758101
93MP0003937_abnormal_limbs/digits/tail_de0.77508179
94MP0005266_abnormal_metabolism0.76518378
95MP0006072_abnormal_retinal_apoptosis0.76108330
96MP0001216_abnormal_epidermal_layer0.75995070
97MP0005423_abnormal_somatic_nervous0.75918090
98MP0004197_abnormal_fetal_growth/weight/0.75661042
99MP0001286_abnormal_eye_development0.75022671
100* MP0002722_abnormal_immune_system0.74961903
101MP0002398_abnormal_bone_marrow0.74861646
102MP0003221_abnormal_cardiomyocyte_apopto0.74817568
103MP0001661_extended_life_span0.74475373
104MP0005499_abnormal_olfactory_system0.73907546
105MP0005394_taste/olfaction_phenotype0.73907546
106MP0008260_abnormal_autophagy0.73688947
107MP0010307_abnormal_tumor_latency0.72909475
108MP0002132_abnormal_respiratory_system0.72242887
109MP0004142_abnormal_muscle_tone0.72070816
110MP0005257_abnormal_intraocular_pressure0.71911571
111MP0002735_abnormal_chemical_nociception0.71822940
112MP0003119_abnormal_digestive_system0.71402100
113MP0009053_abnormal_anal_canal0.71165455
114MP0002092_abnormal_eye_morphology0.70659867
115MP0002095_abnormal_skin_pigmentation0.70650764
116MP0005384_cellular_phenotype0.70635465
117MP0002086_abnormal_extraembryonic_tissu0.69214624
118MP0002098_abnormal_vibrissa_morphology0.69080119
119MP0000750_abnormal_muscle_regeneration0.68643077
120MP0000049_abnormal_middle_ear0.68164680
121MP0010771_integument_phenotype0.68006518
122MP0005451_abnormal_body_composition0.67623047
123MP0003385_abnormal_body_wall0.66727720
124MP0000566_synostosis0.65974796
125MP0004272_abnormal_basement_membrane0.64621476
126MP0008872_abnormal_physiological_respon0.64532982
127* MP0000689_abnormal_spleen_morphology0.64405372
128MP0000653_abnormal_sex_gland0.64356284
129MP0002111_abnormal_tail_morphology0.63239258
130MP0002234_abnormal_pharynx_morphology0.63017810
131MP0005409_darkened_coat_color0.61446721
132MP0001929_abnormal_gametogenesis0.60929259
133MP0005174_abnormal_tail_pigmentation0.60784357
134MP0000377_abnormal_hair_follicle0.60156297
135MP0003861_abnormal_nervous_system0.60044456
136MP0002733_abnormal_thermal_nociception0.59380247
137MP0001919_abnormal_reproductive_system0.59261497
138MP0001849_ear_inflammation0.59113023
139* MP0002429_abnormal_blood_cell0.57951296
140MP0004264_abnormal_extraembryonic_tissu0.57933517
141MP0001243_abnormal_dermal_layer0.56859218
142MP0008873_increased_physiological_sensi0.54935319
143MP0003950_abnormal_plasma_membrane0.54745729
144MP0001186_pigmentation_phenotype0.53998880
145MP0005197_abnormal_uvea_morphology0.52222905
146MP0004782_abnormal_surfactant_physiolog0.50200162

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.50525807
2Abnormal number of erythroid precursors (HP:0012131)5.85720100
3Reticulocytopenia (HP:0001896)5.65461860
4Acute necrotizing encephalopathy (HP:0006965)5.38696968
5Abnormal mitochondria in muscle tissue (HP:0008316)4.90407792
6Mitochondrial inheritance (HP:0001427)4.75708167
7Macrocytic anemia (HP:0001972)4.37342199
8Progressive macrocephaly (HP:0004481)4.35787290
9Increased CSF lactate (HP:0002490)4.19668528
10Birth length less than 3rd percentile (HP:0003561)4.11913675
11Acute encephalopathy (HP:0006846)4.08566701
12Hepatocellular necrosis (HP:0001404)4.07404867
13Pallor (HP:0000980)4.01927805
14Increased hepatocellular lipid droplets (HP:0006565)3.83958759
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.79646082
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.79646082
17Oral leukoplakia (HP:0002745)3.78155438
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64329620
19Aplastic anemia (HP:0001915)3.56002080
20Abnormality of glycolysis (HP:0004366)3.42340165
21Increased serum pyruvate (HP:0003542)3.42340165
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40555497
23Colon cancer (HP:0003003)3.29038983
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.28139670
25Lipid accumulation in hepatocytes (HP:0006561)3.22407198
26Hepatic necrosis (HP:0002605)3.20154818
27Increased serum lactate (HP:0002151)3.18477056
28Breast hypoplasia (HP:0003187)3.16045204
29Exercise intolerance (HP:0003546)3.10651547
303-Methylglutaconic aciduria (HP:0003535)3.08468554
31Rough bone trabeculation (HP:0100670)2.88645440
32Cerebral hypomyelination (HP:0006808)2.84035505
33Respiratory failure (HP:0002878)2.83576113
34Exertional dyspnea (HP:0002875)2.78054086
35Selective tooth agenesis (HP:0001592)2.70176835
36Increased intramyocellular lipid droplets (HP:0012240)2.69351384
37Renal Fanconi syndrome (HP:0001994)2.68975582
38Leukodystrophy (HP:0002415)2.67739600
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65802830
40Carpal bone hypoplasia (HP:0001498)2.65728018
41Increased nuchal translucency (HP:0010880)2.60610448
42Lactic acidosis (HP:0003128)2.60378543
43Cortical dysplasia (HP:0002539)2.59649110
4411 pairs of ribs (HP:0000878)2.58303629
45Cerebral edema (HP:0002181)2.49564331
46Progressive muscle weakness (HP:0003323)2.48487263
47Microretrognathia (HP:0000308)2.47072133
48Abnormal gallbladder physiology (HP:0012438)2.46542448
49Cholecystitis (HP:0001082)2.46542448
50Premature graying of hair (HP:0002216)2.44637762
51Emotional lability (HP:0000712)2.43744638
52Optic disc pallor (HP:0000543)2.41310132
53Respiratory difficulties (HP:0002880)2.40605660
54Absent thumb (HP:0009777)2.36367580
55Reduced antithrombin III activity (HP:0001976)2.34703406
56Sparse eyelashes (HP:0000653)2.33701479
57Patellar aplasia (HP:0006443)2.31662110
58Cellular immunodeficiency (HP:0005374)2.30837620
59Abnormal number of incisors (HP:0011064)2.27513432
60Insomnia (HP:0100785)2.24550517
61Trismus (HP:0000211)2.23092614
62Degeneration of anterior horn cells (HP:0002398)2.21684671
63Abnormality of the anterior horn cell (HP:0006802)2.21684671
64Proximal placement of thumb (HP:0009623)2.20916819
65Ragged-red muscle fibers (HP:0003200)2.18569372
66Glossoptosis (HP:0000162)2.17969747
67Aplasia/Hypoplasia of the patella (HP:0006498)2.16742569
68Overriding aorta (HP:0002623)2.15242327
69Agnosia (HP:0010524)2.12777775
70Horseshoe kidney (HP:0000085)2.12764945
71Abnormality of the umbilical cord (HP:0010881)2.12252508
72Abdominal situs inversus (HP:0003363)2.08895282
73Abnormality of abdominal situs (HP:0011620)2.08895282
74Abnormality of methionine metabolism (HP:0010901)2.08104677
75Deviation of the thumb (HP:0009603)2.07793043
76Hypokinesia (HP:0002375)2.06428614
77Neoplasm of the pancreas (HP:0002894)2.05649159
78Stenosis of the external auditory canal (HP:0000402)2.05220393
79Increased muscle lipid content (HP:0009058)2.04507323
80Abnormality of chromosome stability (HP:0003220)2.03322988
81Hyperacusis (HP:0010780)2.02452913
82Abnormal trabecular bone morphology (HP:0100671)2.02415870
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.01693323
84Cleft eyelid (HP:0000625)2.01038559
85Abnormality of the preputium (HP:0100587)2.00356913
86Pancytopenia (HP:0001876)1.99601733
87Abnormalities of placenta or umbilical cord (HP:0001194)1.99086193
88Meckel diverticulum (HP:0002245)1.99058149
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99044096
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98700249
91Abnormal protein N-linked glycosylation (HP:0012347)1.98700249
92Abnormal protein glycosylation (HP:0012346)1.98700249
93Abnormal glycosylation (HP:0012345)1.98700249
94Abnormal lung lobation (HP:0002101)1.97516383
95Testicular atrophy (HP:0000029)1.96731113
96Absent radius (HP:0003974)1.95867056
97Microvesicular hepatic steatosis (HP:0001414)1.95496739
98Multiple enchondromatosis (HP:0005701)1.94082617
99Triphalangeal thumb (HP:0001199)1.93698342
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91625935
101Abnormality of the carotid arteries (HP:0005344)1.91620049
102Abnormality of the ileum (HP:0001549)1.90874893
103Supernumerary spleens (HP:0009799)1.90123267
104Postnatal microcephaly (HP:0005484)1.89721155
105Duodenal stenosis (HP:0100867)1.89169979
106Small intestinal stenosis (HP:0012848)1.89169979
107Spastic diplegia (HP:0001264)1.87876001
108CNS demyelination (HP:0007305)1.87790159
109CNS hypomyelination (HP:0003429)1.86995988
110Microglossia (HP:0000171)1.86835679
111Depressed nasal ridge (HP:0000457)1.86630288
112Facial cleft (HP:0002006)1.86132080
113Absent forearm bone (HP:0003953)1.85139799
114Aplasia involving forearm bones (HP:0009822)1.85139799
115Overlapping toe (HP:0001845)1.84081047
116Delusions (HP:0000746)1.83036527
117Medulloblastoma (HP:0002885)1.81794656
118Hypoplastic pelvis (HP:0008839)1.80809972
119Abnormality of reticulocytes (HP:0004312)1.78552137
120Gout (HP:0001997)1.78416086
121Progressive external ophthalmoplegia (HP:0000590)1.78118242
122Entropion (HP:0000621)1.78100401
123Asplenia (HP:0001746)1.77762311
124Secondary amenorrhea (HP:0000869)1.75857257
125Elfin facies (HP:0004428)1.75274068
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.75003924
127Chromsome breakage (HP:0040012)1.74495295
128Tracheoesophageal fistula (HP:0002575)1.73647073
129Abnormality of the fetal cardiovascular system (HP:0010948)1.72922144
130Abnormal umbilical cord blood vessels (HP:0011403)1.72922144
131Single umbilical artery (HP:0001195)1.72922144
132Amniotic constriction ring (HP:0009775)1.72784241
133Abnormality of placental membranes (HP:0011409)1.72784241
134Unsteady gait (HP:0002317)1.72579200
135Type I transferrin isoform profile (HP:0003642)1.70474777
136Abnormality of the labia minora (HP:0012880)1.69867589
137Neuroblastoma (HP:0003006)1.69136676
138Primitive neuroectodermal tumor (HP:0030065)1.69136676
139Neuroblastic tumors (HP:0004376)1.69136676
140Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.69136676
141Squamous cell carcinoma (HP:0002860)1.68102202
142Atresia of the external auditory canal (HP:0000413)1.66855512
143Myelodysplasia (HP:0002863)1.65878338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13710892
2WEE14.30900969
3VRK24.03360095
4NME23.51124123
5STK163.29608582
6CDC73.22182389
7TESK23.13247115
8EIF2AK12.99166857
9VRK12.75177985
10NME12.34428296
11TSSK62.32626643
12SRPK12.30617342
13EIF2AK32.08021584
14MAP3K122.04506421
15TESK11.96886765
16PNCK1.93590090
17MST1R1.90285458
18LIMK11.80070149
19SMG11.79266709
20NEK11.78637378
21TLK11.73690831
22SCYL21.71783035
23PLK41.71249269
24KDR1.63899480
25ACVR1B1.63421430
26PLK31.48586843
27PIM21.48396519
28PLK11.46587651
29RPS6KB21.44276865
30PASK1.40151282
31TAF11.36427219
32PAK41.35869713
33BRSK21.34442969
34ARAF1.33289674
35CCNB11.30641197
36AURKA1.30534225
37AURKB1.27595695
38TGFBR11.26509149
39PBK1.22317857
40MKNK11.19783216
41MST41.18366938
42TTK1.17672347
43DAPK11.16750920
44CDK191.16695808
45PDK21.16228240
46NEK21.15839240
47CDK71.13727375
48DYRK31.13551147
49BRSK11.08328031
50ATR1.07255738
51IRAK31.04043312
52ERBB40.96752927
53LRRK20.95812024
54BRAF0.91575934
55GRK60.91143720
56MAP3K80.90154691
57MET0.89790569
58CDK80.88517224
59ILK0.86367962
60CHEK20.80375680
61PAK10.80344965
62CSNK2A20.78702574
63MAP3K110.78546645
64BCKDK0.75555927
65TRIM280.74831397
66DYRK20.74023611
67CSNK2A10.71564093
68RPS6KA40.70491263
69UHMK10.70073963
70PLK20.69570262
71MAP3K100.69276816
72MYLK0.67743777
73CSNK1A1L0.66962591
74CHEK10.65744217
75ICK0.65347284
76MAPKAPK30.64555124
77GRK50.62442462
78CDK140.61437952
79RAF10.60717537
80ALK0.58903438
81CDK11A0.58574301
82CDK120.58202960
83ABL20.57069808
84CDK180.56321157
85CDK150.55975011
86CSNK1G10.52823399
87DAPK30.51843726
88AKT20.51050907
89MINK10.50585677
90EEF2K0.49261492
91PTK20.49192231
92RPS6KA50.48569265
93CSNK1G30.46191589
94PRKCI0.45416664
95EPHA20.45231066
96EIF2AK20.42972736
97CLK10.41841031
98CDK20.40128080
99CDK60.39888403
100CSNK1G20.38636801
101MKNK20.38411624
102CDK40.38279255
103ATM0.38003245
104PAK20.37266700
105MAP2K70.36417558
106ADRBK10.34605069
107CDK10.34148252
108CDK90.34031213
109MAPKAPK50.31504169
110TRIB30.30734529
111BMPR1B0.30618625
112ZAK0.30336761
113STK40.30043250
114LATS20.29537199
115CSNK1E0.28153246
116ADRBK20.27437312
117YES10.25101668
118STK100.23330157
119BCR0.22714666
120SYK0.22085959
121MAPK130.21462705
122TEC0.19340785
123LYN0.18828361
124PIM10.18639656
125CAMK2B0.17695255
126ROCK20.15698667

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.48714597
2Proteasome_Homo sapiens_hsa030504.69827461
3DNA replication_Homo sapiens_hsa030304.44116823
4Mismatch repair_Homo sapiens_hsa034303.74651721
5RNA polymerase_Homo sapiens_hsa030203.56005957
6Oxidative phosphorylation_Homo sapiens_hsa001903.53182448
7Parkinsons disease_Homo sapiens_hsa050123.24927330
8Spliceosome_Homo sapiens_hsa030403.21662704
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88568657
10Pyrimidine metabolism_Homo sapiens_hsa002402.66144851
11Nucleotide excision repair_Homo sapiens_hsa034202.66080057
12Huntingtons disease_Homo sapiens_hsa050162.51924836
13Homologous recombination_Homo sapiens_hsa034402.51498786
14RNA transport_Homo sapiens_hsa030132.41806313
15Base excision repair_Homo sapiens_hsa034102.36338261
16Alzheimers disease_Homo sapiens_hsa050102.22911789
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90726915
18Cell cycle_Homo sapiens_hsa041101.84600256
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.75431127
20Protein export_Homo sapiens_hsa030601.74679191
21One carbon pool by folate_Homo sapiens_hsa006701.72044782
22Non-homologous end-joining_Homo sapiens_hsa034501.62450108
23RNA degradation_Homo sapiens_hsa030181.58494667
24Fanconi anemia pathway_Homo sapiens_hsa034601.52883544
25Fatty acid elongation_Homo sapiens_hsa000621.46373029
26Purine metabolism_Homo sapiens_hsa002301.40038407
27Basal transcription factors_Homo sapiens_hsa030221.38915065
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38308891
29Cardiac muscle contraction_Homo sapiens_hsa042601.18549454
30Vitamin B6 metabolism_Homo sapiens_hsa007501.12929942
31Systemic lupus erythematosus_Homo sapiens_hsa053221.09572948
32p53 signaling pathway_Homo sapiens_hsa041151.03637285
33Epstein-Barr virus infection_Homo sapiens_hsa051691.00888814
34Steroid biosynthesis_Homo sapiens_hsa001000.97166458
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95639386
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94704063
37mRNA surveillance pathway_Homo sapiens_hsa030150.94113867
38Oocyte meiosis_Homo sapiens_hsa041140.93081354
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89826060
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84849631
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80078010
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78995658
43Alcoholism_Homo sapiens_hsa050340.72737230
44Galactose metabolism_Homo sapiens_hsa000520.72591783
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.67836746
46Collecting duct acid secretion_Homo sapiens_hsa049660.62315155
47Vibrio cholerae infection_Homo sapiens_hsa051100.61539020
48Selenocompound metabolism_Homo sapiens_hsa004500.61319256
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61064225
50Sulfur metabolism_Homo sapiens_hsa009200.59921890
51Propanoate metabolism_Homo sapiens_hsa006400.58619902
52Glutathione metabolism_Homo sapiens_hsa004800.58125906
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57622072
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56942264
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.55365226
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55308516
57Biosynthesis of amino acids_Homo sapiens_hsa012300.54069976
58Viral carcinogenesis_Homo sapiens_hsa052030.53332064
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49306063
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48981461
61Pentose phosphate pathway_Homo sapiens_hsa000300.48515798
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48255259
63Fatty acid metabolism_Homo sapiens_hsa012120.47637123
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47530154
65Antigen processing and presentation_Homo sapiens_hsa046120.47217665
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.45302234
67Arginine and proline metabolism_Homo sapiens_hsa003300.44177432
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43246473
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42744868
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42584217
71Metabolic pathways_Homo sapiens_hsa011000.41164445
72Carbon metabolism_Homo sapiens_hsa012000.38392819
73Folate biosynthesis_Homo sapiens_hsa007900.36981314
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36347900
75Sulfur relay system_Homo sapiens_hsa041220.36246636
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35970424
77Arginine biosynthesis_Homo sapiens_hsa002200.34998103
78N-Glycan biosynthesis_Homo sapiens_hsa005100.34930949
79Shigellosis_Homo sapiens_hsa051310.32946771
80HTLV-I infection_Homo sapiens_hsa051660.32375420
81Primary immunodeficiency_Homo sapiens_hsa053400.31433926
82Pyruvate metabolism_Homo sapiens_hsa006200.29171720
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.27701535
84Thyroid cancer_Homo sapiens_hsa052160.23621061
85Herpes simplex infection_Homo sapiens_hsa051680.23229297
86Hippo signaling pathway_Homo sapiens_hsa043900.20891337
87Synaptic vesicle cycle_Homo sapiens_hsa047210.20768390
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20358887
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19736119
90Legionellosis_Homo sapiens_hsa051340.18153758
91Colorectal cancer_Homo sapiens_hsa052100.16663622
92Nicotine addiction_Homo sapiens_hsa050330.16324597
93Phenylalanine metabolism_Homo sapiens_hsa003600.16319455
94Renin-angiotensin system_Homo sapiens_hsa046140.16039278
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15852911
96Peroxisome_Homo sapiens_hsa041460.15741151
97Lysine degradation_Homo sapiens_hsa003100.15645006
98Phagosome_Homo sapiens_hsa041450.14300686
99Adherens junction_Homo sapiens_hsa045200.14021928
100MicroRNAs in cancer_Homo sapiens_hsa052060.13191557
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12172505
102Pancreatic cancer_Homo sapiens_hsa052120.11613738
103Phototransduction_Homo sapiens_hsa047440.11216606
104Tyrosine metabolism_Homo sapiens_hsa003500.10451162
105HIF-1 signaling pathway_Homo sapiens_hsa040660.08494260
106Asthma_Homo sapiens_hsa053100.08296080
107Apoptosis_Homo sapiens_hsa042100.05588225
108Bladder cancer_Homo sapiens_hsa052190.05077770
109Type I diabetes mellitus_Homo sapiens_hsa049400.04183915
110Basal cell carcinoma_Homo sapiens_hsa052170.03537635
111Chronic myeloid leukemia_Homo sapiens_hsa052200.03528623
112Gap junction_Homo sapiens_hsa045400.03277431
113Fructose and mannose metabolism_Homo sapiens_hsa000510.02782027
114Serotonergic synapse_Homo sapiens_hsa047260.02604089
115Hepatitis B_Homo sapiens_hsa051610.02019326
116TGF-beta signaling pathway_Homo sapiens_hsa043500.01714332
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01445375
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.01261316
119Allograft rejection_Homo sapiens_hsa053300.01073599
120Hematopoietic cell lineage_Homo sapiens_hsa046400.00504013
121Pathways in cancer_Homo sapiens_hsa052000.00059094
122Small cell lung cancer_Homo sapiens_hsa05222-0.0404542
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0369867
124Rheumatoid arthritis_Homo sapiens_hsa05323-0.0351235
125Dopaminergic synapse_Homo sapiens_hsa04728-0.0322566
126Melanoma_Homo sapiens_hsa05218-0.0264199
127Amphetamine addiction_Homo sapiens_hsa05031-0.0261912
128Long-term potentiation_Homo sapiens_hsa04720-0.0151715
129Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0083715

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