Rank | Gene Set | Z-score |
---|---|---|
1 | DNA deamination (GO:0045006) | 7.16733913 |
2 | ribosomal small subunit assembly (GO:0000028) | 6.97619346 |
3 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.73915136 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 4.84103378 |
5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.84103378 |
6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.66510429 |
7 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.57678156 |
8 | cytidine metabolic process (GO:0046087) | 4.45876248 |
9 | cytidine catabolic process (GO:0006216) | 4.45876248 |
10 | cytidine deamination (GO:0009972) | 4.45876248 |
11 | behavioral response to nicotine (GO:0035095) | 4.12320267 |
12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.11617920 |
13 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.05488277 |
14 | protein neddylation (GO:0045116) | 3.98856193 |
15 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.97699109 |
16 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.97699109 |
17 | ribosomal large subunit biogenesis (GO:0042273) | 3.96022158 |
18 | protein complex biogenesis (GO:0070271) | 3.95999518 |
19 | maturation of SSU-rRNA (GO:0030490) | 3.95403929 |
20 | proteasome assembly (GO:0043248) | 3.89059734 |
21 | piRNA metabolic process (GO:0034587) | 3.86603645 |
22 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.86048489 |
23 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.86048489 |
24 | NADH dehydrogenase complex assembly (GO:0010257) | 3.86048489 |
25 | protein polyglutamylation (GO:0018095) | 3.85377571 |
26 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.75636856 |
27 | respiratory electron transport chain (GO:0022904) | 3.74883346 |
28 | electron transport chain (GO:0022900) | 3.73689444 |
29 | chaperone-mediated protein transport (GO:0072321) | 3.65664838 |
30 | viral transcription (GO:0019083) | 3.47655797 |
31 | translational termination (GO:0006415) | 3.41575188 |
32 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.40927188 |
33 | platelet dense granule organization (GO:0060155) | 3.40324669 |
34 | protein-cofactor linkage (GO:0018065) | 3.39967418 |
35 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.38565710 |
36 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.36570987 |
37 | negative regulation of mast cell activation (GO:0033004) | 3.28711679 |
38 | phosphorylated carbohydrate dephosphorylation (GO:0046838) | 3.28654710 |
39 | inositol phosphate dephosphorylation (GO:0046855) | 3.28654710 |
40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.28342782 |
41 | termination of RNA polymerase III transcription (GO:0006386) | 3.28342782 |
42 | ribosomal small subunit biogenesis (GO:0042274) | 3.23076390 |
43 | regulation of cilium movement (GO:0003352) | 3.20932248 |
44 | negative regulation of telomere maintenance (GO:0032205) | 3.18985491 |
45 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.18319313 |
46 | translational elongation (GO:0006414) | 3.16370841 |
47 | regulation of chronic inflammatory response (GO:0002676) | 3.15784829 |
48 | protein targeting to ER (GO:0045047) | 3.12976243 |
49 | ketone body metabolic process (GO:1902224) | 3.12975770 |
50 | cotranslational protein targeting to membrane (GO:0006613) | 3.09613120 |
51 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 3.06526279 |
52 | pseudouridine synthesis (GO:0001522) | 3.04289012 |
53 | hydrogen ion transmembrane transport (GO:1902600) | 2.99334154 |
54 | base-excision repair, AP site formation (GO:0006285) | 2.98789832 |
55 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 2.98277456 |
56 | cellular ketone body metabolic process (GO:0046950) | 2.96506688 |
57 | axoneme assembly (GO:0035082) | 2.96193194 |
58 | positive regulation of defense response to virus by host (GO:0002230) | 2.93481086 |
59 | inositol phosphate catabolic process (GO:0071545) | 2.92677569 |
60 | protein localization to endoplasmic reticulum (GO:0070972) | 2.91707289 |
61 | ATP biosynthetic process (GO:0006754) | 2.89088860 |
62 | mannosylation (GO:0097502) | 2.87393320 |
63 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.85317584 |
64 | cellular component biogenesis (GO:0044085) | 2.84504752 |
65 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.84096405 |
66 | regulation of action potential (GO:0098900) | 2.83100652 |
67 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.81609297 |
68 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.80706705 |
69 | proton transport (GO:0015992) | 2.79634508 |
70 | translation (GO:0006412) | 2.77650670 |
71 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.77587470 |
72 | ubiquinone biosynthetic process (GO:0006744) | 2.76449934 |
73 | hydrogen transport (GO:0006818) | 2.76186213 |
74 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.75502160 |
75 | regulation of mitochondrial translation (GO:0070129) | 2.74549938 |
76 | positive regulation of humoral immune response (GO:0002922) | 2.74096581 |
77 | GPI anchor metabolic process (GO:0006505) | 2.74052565 |
78 | branched-chain amino acid catabolic process (GO:0009083) | 2.70280747 |
79 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 2.69510235 |
80 | tRNA processing (GO:0008033) | 2.69428936 |
81 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.69360103 |
82 | anterograde synaptic vesicle transport (GO:0048490) | 2.68370941 |
83 | protein K6-linked ubiquitination (GO:0085020) | 2.65604653 |
84 | L-fucose catabolic process (GO:0042355) | 2.65349186 |
85 | fucose catabolic process (GO:0019317) | 2.65349186 |
86 | L-fucose metabolic process (GO:0042354) | 2.65349186 |
87 | GPI anchor biosynthetic process (GO:0006506) | 2.65171671 |
88 | cellular protein complex disassembly (GO:0043624) | 2.64075564 |
89 | male meiosis I (GO:0007141) | 2.62979491 |
90 | deoxyribonucleotide catabolic process (GO:0009264) | 2.62821152 |
91 | cellular response to exogenous dsRNA (GO:0071360) | 2.60670781 |
92 | phosphatidylinositol acyl-chain remodeling (GO:0036149) | 2.60053776 |
93 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.58932138 |
94 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.58329356 |
95 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.58329356 |
96 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.58329356 |
97 | deoxyribose phosphate catabolic process (GO:0046386) | 2.58294502 |
98 | vitamin biosynthetic process (GO:0009110) | 2.57947128 |
99 | GTP biosynthetic process (GO:0006183) | 2.57924017 |
100 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.57563427 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.88471235 |
2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.79749724 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.77218548 |
4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.76998859 |
5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.50904796 |
6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.18009639 |
7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.14826719 |
8 | VDR_22108803_ChIP-Seq_LS180_Human | 3.13945005 |
9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.06283364 |
10 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.03365902 |
11 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.56417748 |
12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52958149 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.42523171 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.40746106 |
15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.31482040 |
16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.29396045 |
17 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.03351379 |
18 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.02569182 |
19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.97679061 |
20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91965291 |
21 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.91056894 |
22 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.78924279 |
23 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.77327504 |
24 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.74749358 |
25 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.74274526 |
26 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.72436422 |
27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.72142704 |
28 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.68330099 |
29 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.66417467 |
30 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66349917 |
31 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.63336164 |
32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.60959401 |
33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.56323718 |
34 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.55462435 |
35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.54730532 |
36 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.47337226 |
37 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.46756163 |
38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41845022 |
39 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.40960653 |
40 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.40635836 |
41 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.33808648 |
42 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.28171747 |
43 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.27282294 |
44 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.26613075 |
45 | AR_20517297_ChIP-Seq_VCAP_Human | 1.25746685 |
46 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.24828967 |
47 | * FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.24708946 |
48 | * FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.24708946 |
49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.23613175 |
50 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22285014 |
51 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.22009404 |
52 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.21342550 |
53 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.19736659 |
54 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.19542208 |
55 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19163856 |
56 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.18951870 |
57 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.17454974 |
58 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.16240078 |
59 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.13356984 |
60 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.12321958 |
61 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.12066931 |
62 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.11549853 |
63 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.11549853 |
64 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.10411169 |
65 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.09873874 |
66 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.09349384 |
67 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.08109118 |
68 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.08065397 |
69 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.07095224 |
70 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05583518 |
71 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.04206041 |
72 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.03102673 |
73 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.03031825 |
74 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.02759149 |
75 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.02759149 |
76 | * GATA3_26560356_Chip-Seq_TH2_Human | 1.01879721 |
77 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.01103011 |
78 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.00134597 |
79 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.98564144 |
80 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.97884055 |
81 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.97721581 |
82 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.96012219 |
83 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.95871095 |
84 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.95322975 |
85 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.95231899 |
86 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.94576010 |
87 | P300_19829295_ChIP-Seq_ESCs_Human | 0.94551557 |
88 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.92470876 |
89 | * NANOG_20526341_ChIP-Seq_ESCs_Human | 0.91576581 |
90 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.90957926 |
91 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.90247849 |
92 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88651961 |
93 | NCOR_22424771_ChIP-Seq_293T_Human | 0.88461518 |
94 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.88426982 |
95 | ERA_21632823_ChIP-Seq_H3396_Human | 0.88248294 |
96 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.87649535 |
97 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.87632970 |
98 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.86959323 |
99 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.85562866 |
100 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.85030273 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0005645_abnormal_hypothalamus_physiol | 3.60894787 |
2 | MP0006292_abnormal_olfactory_placode | 3.18863776 |
3 | MP0002102_abnormal_ear_morphology | 2.96713871 |
4 | MP0005671_abnormal_response_to | 2.72634269 |
5 | MP0009379_abnormal_foot_pigmentation | 2.61905149 |
6 | MP0008875_abnormal_xenobiotic_pharmacok | 2.23569015 |
7 | MP0008877_abnormal_DNA_methylation | 2.20974083 |
8 | MP0006276_abnormal_autonomic_nervous | 2.15486543 |
9 | MP0003724_increased_susceptibility_to | 2.14061786 |
10 | MP0006072_abnormal_retinal_apoptosis | 2.02675532 |
11 | MP0005084_abnormal_gallbladder_morpholo | 2.00552429 |
12 | MP0008872_abnormal_physiological_respon | 1.98772664 |
13 | MP0005551_abnormal_eye_electrophysiolog | 1.93191877 |
14 | MP0002138_abnormal_hepatobiliary_system | 1.91073400 |
15 | MP0004142_abnormal_muscle_tone | 1.85887383 |
16 | MP0005377_hearing/vestibular/ear_phenot | 1.85093511 |
17 | MP0003878_abnormal_ear_physiology | 1.85093511 |
18 | MP0001986_abnormal_taste_sensitivity | 1.81684472 |
19 | MP0001968_abnormal_touch/_nociception | 1.79434562 |
20 | MP0001485_abnormal_pinna_reflex | 1.75318181 |
21 | MP0002653_abnormal_ependyma_morphology | 1.74491901 |
22 | MP0000372_irregular_coat_pigmentation | 1.73167676 |
23 | MP0003195_calcinosis | 1.70368147 |
24 | MP0000465_gastrointestinal_hemorrhage | 1.70022717 |
25 | MP0002733_abnormal_thermal_nociception | 1.65018895 |
26 | MP0004885_abnormal_endolymph | 1.63769620 |
27 | MP0001529_abnormal_vocalization | 1.61026304 |
28 | MP0002163_abnormal_gland_morphology | 1.58678265 |
29 | MP0002272_abnormal_nervous_system | 1.58659714 |
30 | MP0003011_delayed_dark_adaptation | 1.58538899 |
31 | MP0008058_abnormal_DNA_repair | 1.57359481 |
32 | MP0002254_reproductive_system_inflammat | 1.53554427 |
33 | MP0002736_abnormal_nociception_after | 1.53221516 |
34 | MP0001905_abnormal_dopamine_level | 1.50527299 |
35 | MP0005646_abnormal_pituitary_gland | 1.48247642 |
36 | MP0005253_abnormal_eye_physiology | 1.47748419 |
37 | MP0005075_abnormal_melanosome_morpholog | 1.45422830 |
38 | MP0006036_abnormal_mitochondrial_physio | 1.43562839 |
39 | MP0003806_abnormal_nucleotide_metabolis | 1.42146566 |
40 | MP0004742_abnormal_vestibular_system | 1.41498865 |
41 | MP0002277_abnormal_respiratory_mucosa | 1.39330992 |
42 | MP0005389_reproductive_system_phenotype | 1.37505169 |
43 | MP0002837_dystrophic_cardiac_calcinosis | 1.36334453 |
44 | MP0004145_abnormal_muscle_electrophysio | 1.36244638 |
45 | MP0001919_abnormal_reproductive_system | 1.34672990 |
46 | MP0002234_abnormal_pharynx_morphology | 1.32791112 |
47 | MP0001970_abnormal_pain_threshold | 1.32588501 |
48 | MP0002876_abnormal_thyroid_physiology | 1.30148375 |
49 | MP0001486_abnormal_startle_reflex | 1.29805486 |
50 | MP0003880_abnormal_central_pattern | 1.28617196 |
51 | MP0008789_abnormal_olfactory_epithelium | 1.19272767 |
52 | MP0004043_abnormal_pH_regulation | 1.18688342 |
53 | MP0002909_abnormal_adrenal_gland | 1.17556466 |
54 | MP0009764_decreased_sensitivity_to | 1.16623000 |
55 | MP0001501_abnormal_sleep_pattern | 1.15975646 |
56 | MP0003786_premature_aging | 1.12431011 |
57 | MP0009745_abnormal_behavioral_response | 1.11947163 |
58 | MP0003136_yellow_coat_color | 1.10696317 |
59 | MP0009785_altered_susceptibility_to | 1.09713786 |
60 | MP0002638_abnormal_pupillary_reflex | 1.09434232 |
61 | MP0008995_early_reproductive_senescence | 1.06023818 |
62 | MP0001293_anophthalmia | 1.05223763 |
63 | MP0001835_abnormal_antigen_presentation | 1.04235049 |
64 | MP0003186_abnormal_redox_activity | 1.01378870 |
65 | MP0002148_abnormal_hypersensitivity_rea | 0.99124884 |
66 | MP0010386_abnormal_urinary_bladder | 0.98207580 |
67 | MP0001963_abnormal_hearing_physiology | 0.96238239 |
68 | MP0001873_stomach_inflammation | 0.94884556 |
69 | MP0002095_abnormal_skin_pigmentation | 0.94316166 |
70 | MP0005174_abnormal_tail_pigmentation | 0.94141996 |
71 | MP0003763_abnormal_thymus_physiology | 0.93731991 |
72 | MP0000685_abnormal_immune_system | 0.93056104 |
73 | MP0003646_muscle_fatigue | 0.92567574 |
74 | MP0001800_abnormal_humoral_immune | 0.92257752 |
75 | MP0009333_abnormal_splenocyte_physiolog | 0.90679563 |
76 | MP0003718_maternal_effect | 0.90509735 |
77 | MP0005000_abnormal_immune_tolerance | 0.90392263 |
78 | MP0005379_endocrine/exocrine_gland_phen | 0.90290413 |
79 | MP0004147_increased_porphyrin_level | 0.90110280 |
80 | MP0000631_abnormal_neuroendocrine_gland | 0.90031247 |
81 | MP0005410_abnormal_fertilization | 0.89486118 |
82 | MP0003635_abnormal_synaptic_transmissio | 0.88748058 |
83 | MP0001790_abnormal_immune_system | 0.87065818 |
84 | MP0005387_immune_system_phenotype | 0.87065818 |
85 | MP0002184_abnormal_innervation | 0.83127705 |
86 | MP0004381_abnormal_hair_follicle | 0.82550044 |
87 | MP0002723_abnormal_immune_serum | 0.82086244 |
88 | MP0002557_abnormal_social/conspecific_i | 0.80533284 |
89 | MP0003137_abnormal_impulse_conducting | 0.79553522 |
90 | MP0002160_abnormal_reproductive_system | 0.77105763 |
91 | MP0001929_abnormal_gametogenesis | 0.76984806 |
92 | MP0002210_abnormal_sex_determination | 0.76954742 |
93 | MP0005167_abnormal_blood-brain_barrier | 0.75989697 |
94 | MP0002006_tumorigenesis | 0.74299492 |
95 | MP0005195_abnormal_posterior_eye | 0.74211275 |
96 | MP0002572_abnormal_emotion/affect_behav | 0.73462505 |
97 | MP0002420_abnormal_adaptive_immunity | 0.73170303 |
98 | MP0003866_abnormal_defecation | 0.73085706 |
99 | MP0003122_maternal_imprinting | 0.72384026 |
100 | MP0004133_heterotaxia | 0.72106111 |
Rank | Gene Set | Z-score |
---|---|---|
1 | 3-Methylglutaconic aciduria (HP:0003535) | 4.81584966 |
2 | Acute necrotizing encephalopathy (HP:0006965) | 4.53019390 |
3 | Mitochondrial inheritance (HP:0001427) | 4.20433628 |
4 | Hepatocellular necrosis (HP:0001404) | 4.12146586 |
5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.09226788 |
6 | Acute encephalopathy (HP:0006846) | 4.07136184 |
7 | Increased CSF lactate (HP:0002490) | 4.01552296 |
8 | Hepatic necrosis (HP:0002605) | 3.67549340 |
9 | Progressive macrocephaly (HP:0004481) | 3.66741250 |
10 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.49775167 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.45794699 |
12 | Congenital stationary night blindness (HP:0007642) | 3.33050483 |
13 | Pancreatic cysts (HP:0001737) | 3.27048247 |
14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.24717523 |
15 | Pancreatic fibrosis (HP:0100732) | 3.16392575 |
16 | Cerebral edema (HP:0002181) | 3.09730926 |
17 | Molar tooth sign on MRI (HP:0002419) | 3.05498080 |
18 | Abnormality of midbrain morphology (HP:0002418) | 3.05498080 |
19 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.00461026 |
20 | Abnormality of the labia minora (HP:0012880) | 2.90583154 |
21 | Increased serum lactate (HP:0002151) | 2.81978374 |
22 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.81229589 |
23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.80241121 |
24 | Type 2 muscle fiber atrophy (HP:0003554) | 2.75262210 |
25 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.73148102 |
26 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.71890757 |
27 | Reticulocytopenia (HP:0001896) | 2.68900877 |
28 | True hermaphroditism (HP:0010459) | 2.63753057 |
29 | Renal Fanconi syndrome (HP:0001994) | 2.60759055 |
30 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.58461074 |
31 | Optic disc pallor (HP:0000543) | 2.51262541 |
32 | Abnormal number of erythroid precursors (HP:0012131) | 2.50106843 |
33 | Muscle fiber atrophy (HP:0100295) | 2.46920475 |
34 | Abnormality of alanine metabolism (HP:0010916) | 2.43206795 |
35 | Hyperalaninemia (HP:0003348) | 2.43206795 |
36 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.43206795 |
37 | Increased intramyocellular lipid droplets (HP:0012240) | 2.42692410 |
38 | Methylmalonic acidemia (HP:0002912) | 2.41357992 |
39 | Nephronophthisis (HP:0000090) | 2.40577009 |
40 | Lactic acidosis (HP:0003128) | 2.40415534 |
41 | IgG deficiency (HP:0004315) | 2.40365366 |
42 | Respiratory failure (HP:0002878) | 2.38707738 |
43 | Pendular nystagmus (HP:0012043) | 2.36988327 |
44 | Abolished electroretinogram (ERG) (HP:0000550) | 2.36837181 |
45 | Hypomagnesemia (HP:0002917) | 2.35823227 |
46 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.35143782 |
47 | Hypoplasia of the uterus (HP:0000013) | 2.29165357 |
48 | Short tibia (HP:0005736) | 2.24728600 |
49 | Medial flaring of the eyebrow (HP:0010747) | 2.24561179 |
50 | Lethargy (HP:0001254) | 2.23976323 |
51 | Exertional dyspnea (HP:0002875) | 2.18710107 |
52 | Abnormality of the renal medulla (HP:0100957) | 2.18626899 |
53 | Exercise intolerance (HP:0003546) | 2.18426368 |
54 | Methylmalonic aciduria (HP:0012120) | 2.17751556 |
55 | Decreased central vision (HP:0007663) | 2.17502609 |
56 | Chorioretinal atrophy (HP:0000533) | 2.17250454 |
57 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.16692623 |
58 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.15354097 |
59 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.15354097 |
60 | Abnormal protein glycosylation (HP:0012346) | 2.15354097 |
61 | Abnormal glycosylation (HP:0012345) | 2.15354097 |
62 | Congenital hepatic fibrosis (HP:0002612) | 2.14270607 |
63 | Parakeratosis (HP:0001036) | 2.12836248 |
64 | Asplenia (HP:0001746) | 2.11170592 |
65 | Hyperglycinemia (HP:0002154) | 2.08108329 |
66 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.06708298 |
67 | Abnormality of the renal cortex (HP:0011035) | 2.05741136 |
68 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.03893516 |
69 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.03893516 |
70 | Increased muscle lipid content (HP:0009058) | 2.01163777 |
71 | Aplastic anemia (HP:0001915) | 1.98888853 |
72 | Macrocytic anemia (HP:0001972) | 1.98881157 |
73 | Attenuation of retinal blood vessels (HP:0007843) | 1.97110865 |
74 | Leukodystrophy (HP:0002415) | 1.94789341 |
75 | Abnormality of B cell number (HP:0010975) | 1.93647610 |
76 | Colon cancer (HP:0003003) | 1.93020349 |
77 | Absent thumb (HP:0009777) | 1.89703195 |
78 | Ketosis (HP:0001946) | 1.88583109 |
79 | Abnormality of magnesium homeostasis (HP:0004921) | 1.88355794 |
80 | Retinal dysplasia (HP:0007973) | 1.88339582 |
81 | Congenital, generalized hypertrichosis (HP:0004540) | 1.87730053 |
82 | B lymphocytopenia (HP:0010976) | 1.86866324 |
83 | CNS demyelination (HP:0007305) | 1.86063568 |
84 | Cystic liver disease (HP:0006706) | 1.85256464 |
85 | Agitation (HP:0000713) | 1.84763889 |
86 | Myositis (HP:0100614) | 1.84516867 |
87 | Adactyly (HP:0009776) | 1.83995656 |
88 | Thyroid-stimulating hormone excess (HP:0002925) | 1.83935948 |
89 | Increased corneal curvature (HP:0100692) | 1.80534110 |
90 | Keratoconus (HP:0000563) | 1.80534110 |
91 | Abnormal biliary tract physiology (HP:0012439) | 1.80224791 |
92 | Bile duct proliferation (HP:0001408) | 1.80224791 |
93 | Emotional lability (HP:0000712) | 1.79492585 |
94 | Supernumerary spleens (HP:0009799) | 1.77166447 |
95 | Inability to walk (HP:0002540) | 1.76233901 |
96 | Abnormality of urine glucose concentration (HP:0011016) | 1.76001293 |
97 | Glycosuria (HP:0003076) | 1.76001293 |
98 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.73783899 |
99 | Hypoplasia of the fovea (HP:0007750) | 1.73783899 |
100 | Abnormality of the anterior horn cell (HP:0006802) | 1.72752107 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP4K2 | 5.61861242 |
2 | BCKDK | 3.41099066 |
3 | TLK1 | 3.24191142 |
4 | ZAK | 2.87178658 |
5 | TXK | 2.58648691 |
6 | WNK4 | 2.34013377 |
7 | NME1 | 2.22766121 |
8 | GRK1 | 2.15262665 |
9 | ADRBK2 | 2.12502689 |
10 | TAOK3 | 2.10967332 |
11 | VRK2 | 2.00046128 |
12 | GRK6 | 1.91408130 |
13 | NUAK1 | 1.85905357 |
14 | FES | 1.71676950 |
15 | MAP4K1 | 1.63419342 |
16 | VRK1 | 1.58779840 |
17 | CSNK1G3 | 1.53082129 |
18 | KDR | 1.52702208 |
19 | WNK3 | 1.52399132 |
20 | INSRR | 1.51163413 |
21 | PINK1 | 1.51152009 |
22 | MAP3K12 | 1.50300058 |
23 | FRK | 1.48979401 |
24 | TESK2 | 1.47123363 |
25 | CSNK1G2 | 1.44714589 |
26 | CSNK1G1 | 1.41145387 |
27 | DAPK1 | 1.40046139 |
28 | STK39 | 1.39839846 |
29 | BUB1 | 1.29711242 |
30 | CSNK1A1L | 1.23701123 |
31 | MST4 | 1.18874228 |
32 | MAP2K6 | 1.17961730 |
33 | OXSR1 | 1.11932438 |
34 | DYRK2 | 1.11158979 |
35 | PASK | 1.11123069 |
36 | MAP3K4 | 1.00716892 |
37 | TIE1 | 0.98717832 |
38 | MAP3K11 | 0.92025862 |
39 | PRKCQ | 0.91506621 |
40 | MAP2K7 | 0.88798021 |
41 | CAMKK2 | 0.86367685 |
42 | STK16 | 0.85425973 |
43 | CDK19 | 0.84138178 |
44 | OBSCN | 0.84002906 |
45 | IKBKB | 0.81883345 |
46 | TSSK6 | 0.81822388 |
47 | TRIM28 | 0.80199314 |
48 | PIM1 | 0.78291919 |
49 | LIMK1 | 0.77371690 |
50 | DAPK2 | 0.75512758 |
51 | BMPR1B | 0.73194901 |
52 | NEK1 | 0.71189807 |
53 | MKNK1 | 0.70658720 |
54 | BTK | 0.70277733 |
55 | NEK2 | 0.67349403 |
56 | ITK | 0.66585602 |
57 | ALK | 0.65095129 |
58 | TEC | 0.64056333 |
59 | SYK | 0.63117978 |
60 | PBK | 0.62101954 |
61 | DAPK3 | 0.61001724 |
62 | PHKG1 | 0.59851504 |
63 | PHKG2 | 0.59851504 |
64 | MATK | 0.58995355 |
65 | RPS6KA5 | 0.57943365 |
66 | ADRBK1 | 0.57407236 |
67 | BRSK2 | 0.55942954 |
68 | MAPKAPK3 | 0.55565704 |
69 | LYN | 0.53979548 |
70 | MAP3K5 | 0.52402885 |
71 | LRRK2 | 0.51254226 |
72 | PRKCG | 0.50825635 |
73 | NME2 | 0.50277280 |
74 | KIT | 0.50208932 |
75 | TNK2 | 0.49015775 |
76 | SRPK1 | 0.48981019 |
77 | IKBKE | 0.46819900 |
78 | CSNK2A2 | 0.46278532 |
79 | CAMK2A | 0.44037631 |
80 | TAF1 | 0.43836440 |
81 | NTRK2 | 0.43058701 |
82 | MAP2K2 | 0.42889010 |
83 | MAPKAPK5 | 0.41544793 |
84 | MINK1 | 0.40934556 |
85 | CSNK2A1 | 0.40490596 |
86 | CAMK1 | 0.39568813 |
87 | PIK3CG | 0.38189969 |
88 | PIK3CA | 0.38121415 |
89 | IGF1R | 0.37442112 |
90 | PRKACA | 0.37437808 |
91 | MARK3 | 0.37326421 |
92 | PLK3 | 0.36918275 |
93 | CSNK1D | 0.35779141 |
94 | ATR | 0.35103187 |
95 | LCK | 0.35012667 |
96 | EIF2AK3 | 0.34839899 |
97 | PRKCI | 0.34772803 |
98 | CSNK1A1 | 0.34268663 |
99 | CCNB1 | 0.33891283 |
100 | MAPK13 | 0.33639004 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.83615695 |
2 | Ribosome_Homo sapiens_hsa03010 | 3.66272857 |
3 | Proteasome_Homo sapiens_hsa03050 | 3.45981529 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.26412382 |
5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.81873423 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.75361528 |
7 | Protein export_Homo sapiens_hsa03060 | 2.39485485 |
8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.16533726 |
9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.11101500 |
10 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.09853021 |
11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.08708092 |
12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.07408736 |
13 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.99027094 |
14 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.95906650 |
15 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.91123159 |
16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.85711443 |
17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.84467564 |
18 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.78997982 |
19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.75616159 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.65088644 |
21 | Phototransduction_Homo sapiens_hsa04744 | 1.63766631 |
22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.56455861 |
23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.55079475 |
24 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.47424534 |
25 | RNA degradation_Homo sapiens_hsa03018 | 1.45179448 |
26 | Homologous recombination_Homo sapiens_hsa03440 | 1.43792980 |
27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41969615 |
28 | Peroxisome_Homo sapiens_hsa04146 | 1.38435220 |
29 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.37423200 |
30 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.34744423 |
31 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.31194797 |
32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.28670003 |
33 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.27966553 |
34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.20956666 |
35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.15712698 |
36 | Purine metabolism_Homo sapiens_hsa00230 | 1.15141216 |
37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.09362306 |
38 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.01627928 |
39 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.98836482 |
40 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.97987857 |
41 | Basal transcription factors_Homo sapiens_hsa03022 | 0.95981929 |
42 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.94540303 |
43 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.93799779 |
44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.91566938 |
45 | Asthma_Homo sapiens_hsa05310 | 0.86266240 |
46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.85945333 |
47 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.83777128 |
48 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.83093904 |
49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.83017178 |
50 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.80908611 |
51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.80764285 |
52 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.79169561 |
53 | Base excision repair_Homo sapiens_hsa03410 | 0.78432356 |
54 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.78307937 |
55 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.77902832 |
56 | Allograft rejection_Homo sapiens_hsa05330 | 0.76534876 |
57 | RNA transport_Homo sapiens_hsa03013 | 0.76152743 |
58 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.73550916 |
59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.73495213 |
60 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.70432343 |
61 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.69347942 |
62 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.68459126 |
63 | Taste transduction_Homo sapiens_hsa04742 | 0.64266364 |
64 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.63431101 |
65 | Retinol metabolism_Homo sapiens_hsa00830 | 0.62950480 |
66 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.61344422 |
67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59231048 |
68 | Olfactory transduction_Homo sapiens_hsa04740 | 0.58921273 |
69 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.57463553 |
70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.57017216 |
71 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.56249611 |
72 | Spliceosome_Homo sapiens_hsa03040 | 0.55919449 |
73 | Morphine addiction_Homo sapiens_hsa05032 | 0.55889107 |
74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.53743427 |
75 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.53279504 |
76 | Nicotine addiction_Homo sapiens_hsa05033 | 0.52750323 |
77 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.51635165 |
78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.49573031 |
79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.49539440 |
80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.47572866 |
81 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46627965 |
82 | Salivary secretion_Homo sapiens_hsa04970 | 0.45981569 |
83 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.45129474 |
84 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.45109747 |
85 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44670426 |
86 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.44442229 |
87 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.43986000 |
88 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43302899 |
89 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.43260870 |
90 | Mismatch repair_Homo sapiens_hsa03430 | 0.39666275 |
91 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.38834171 |
92 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.37945491 |
93 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.36506910 |
94 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.35400357 |
95 | Insulin secretion_Homo sapiens_hsa04911 | 0.32383840 |
96 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.28450626 |
97 | GABAergic synapse_Homo sapiens_hsa04727 | 0.27820435 |
98 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.26950437 |
99 | Sulfur relay system_Homo sapiens_hsa04122 | 0.26551529 |
100 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.25542177 |