ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.12152548
2	imidazole-containing compound metabolic process (GO:0052803)	5.80497257
3	pyrimidine nucleotide catabolic process (GO:0006244)	5.25816385
4	DNA deamination (GO:0045006)	4.68107359
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21058444
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21058444
7	NADH dehydrogenase complex assembly (GO:0010257)	4.21058444
8	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.07508103
9	organic cation transport (GO:0015695)	4.05770667
10	protein complex biogenesis (GO:0070271)	3.91652147
11	protein-cofactor linkage (GO:0018065)	3.85428255
12	protein polyglutamylation (GO:0018095)	3.83256251
13	purine-containing compound salvage (GO:0043101)	3.74006216
14	kynurenine metabolic process (GO:0070189)	3.73618150
15	replication fork processing (GO:0031297)	3.67769735
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.65465009
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.56403983
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.56403983
19	inner mitochondrial membrane organization (GO:0007007)	3.50851306
20	rRNA modification (GO:0000154)	3.43321287
21	behavioral response to nicotine (GO:0035095)	3.38834730
22	GMP metabolic process (GO:0046037)	3.36742382
23	sulfur amino acid catabolic process (GO:0000098)	3.33336084
24	base-excision repair, AP site formation (GO:0006285)	3.31221287
25	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.30750770
26	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.30750770
27	peroxisome fission (GO:0016559)	3.24783547
28	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.16576068
29	mitochondrial RNA metabolic process (GO:0000959)	3.14378144
30	tryptophan metabolic process (GO:0006568)	3.08562377
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06070937
32	tryptophan catabolic process (GO:0006569)	3.05771164
33	indole-containing compound catabolic process (GO:0042436)	3.05771164
34	indolalkylamine catabolic process (GO:0046218)	3.05771164
35	purine nucleotide salvage (GO:0032261)	3.05115313
36	pseudouridine synthesis (GO:0001522)	3.05084987
37	adenosine metabolic process (GO:0046085)	3.04291762
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.98034938
39	iron-sulfur cluster assembly (GO:0016226)	2.95554367
40	metallo-sulfur cluster assembly (GO:0031163)	2.95554367
41	rRNA methylation (GO:0031167)	2.92191416
42	cysteine metabolic process (GO:0006534)	2.89487997
43	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.88431012
44	cytidine metabolic process (GO:0046087)	2.86969603
45	cytidine catabolic process (GO:0006216)	2.86969603
46	cytidine deamination (GO:0009972)	2.86969603
47	rRNA catabolic process (GO:0016075)	2.85385014
48	indolalkylamine metabolic process (GO:0006586)	2.84306574
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.83842404
50	ATP synthesis coupled proton transport (GO:0015986)	2.83842404
51	regulation of T cell cytokine production (GO:0002724)	2.83350182
52	cellular biogenic amine biosynthetic process (GO:0042401)	2.80311283
53	positive regulation of histone H3-K4 methylation (GO:0051571)	2.80052630
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77728858
55	deoxyribonucleotide catabolic process (GO:0009264)	2.76864928
56	urate metabolic process (GO:0046415)	2.75819086
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73937145
58	amine biosynthetic process (GO:0009309)	2.73578858
59	positive regulation of mitochondrial fission (GO:0090141)	2.73521409
60	tRNA processing (GO:0008033)	2.72723472
61	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71651264
62	nucleoside transmembrane transport (GO:1901642)	2.71535546
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.70798748
64	respiratory chain complex IV assembly (GO:0008535)	2.70254300
65	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.68702380
66	centriole replication (GO:0007099)	2.66811558
67	ubiquinone biosynthetic process (GO:0006744)	2.65148132
68	transcription from mitochondrial promoter (GO:0006390)	2.63287008
69	deoxyribose phosphate catabolic process (GO:0046386)	2.62982563
70	catecholamine biosynthetic process (GO:0042423)	2.62477373
71	catechol-containing compound biosynthetic process (GO:0009713)	2.62477373
72	folic acid-containing compound biosynthetic process (GO:0009396)	2.61255622
73	mannosylation (GO:0097502)	2.60932347
74	microtubule nucleation (GO:0007020)	2.60903804
75	amino acid salvage (GO:0043102)	2.60781889
76	L-methionine salvage (GO:0071267)	2.60781889
77	L-methionine biosynthetic process (GO:0071265)	2.60781889
78	tRNA modification (GO:0006400)	2.60267026
79	pyrimidine-containing compound catabolic process (GO:0072529)	2.60266575
80	negative regulation of mast cell activation (GO:0033004)	2.59530942
81	regulation of penile erection (GO:0060405)	2.58487357
82	male meiosis I (GO:0007141)	2.58261370
83	axoneme assembly (GO:0035082)	2.56823810
84	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.56535223
85	alternative mRNA splicing, via spliceosome (GO:0000380)	2.55125000
86	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.53337182
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.52897610
88	cytochrome complex assembly (GO:0017004)	2.52668699
89	benzene-containing compound metabolic process (GO:0042537)	2.52137677
90	electron transport chain (GO:0022900)	2.52078775
91	respiratory electron transport chain (GO:0022904)	2.49784669
92	protein K11-linked deubiquitination (GO:0035871)	2.49376820
93	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.48345145
94	arginine catabolic process (GO:0006527)	2.48166527
95	behavioral response to ethanol (GO:0048149)	2.48141025
96	platelet dense granule organization (GO:0060155)	2.47867567
97	negative regulation of acute inflammatory response (GO:0002674)	2.46569781
98	positive regulation of defense response to virus by host (GO:0002230)	2.46195076
99	male meiosis (GO:0007140)	2.44049098
100	mitochondrial calcium ion transport (GO:0006851)	2.43220926

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.63954484
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.19816474
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.56627531
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.33338034
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.16922610
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.11790463
7	VDR_22108803_ChIP-Seq_LS180_Human	3.08746607
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.06591699
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89095273
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.84903377
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.80702330
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.76817767
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.65519916
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53463871
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.16014040
16	TP53_22573176_ChIP-Seq_HFKS_Human	2.03086719
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97912012
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.97655078
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96302041
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91725164
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.89601445
22	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.89404029
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.78697488
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75364292
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72303631
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.65415805
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64198090
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59726698
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.56491754
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55559588
31	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54717895
32	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54459030
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.51001638
34	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.49519365
35	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.47798919
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46253623
37	NCOR_22424771_ChIP-Seq_293T_Human	1.42258567
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.37934226
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.37465345
40	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37319675
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34252601
42	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31751812
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31311746
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.31311746
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30832770
46	EWS_26573619_Chip-Seq_HEK293_Human	1.24328373
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21341657
48	FUS_26573619_Chip-Seq_HEK293_Human	1.20203526
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19114897
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19114897
51	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.16927887
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15575154
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.14025825
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12393304
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.10476597
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10108056
57	AR_20517297_ChIP-Seq_VCAP_Human	1.09278845
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08222654
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08113531
60	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07987859
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07505731
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05967986
63	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05549610
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05045634
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03732741
66	TTF2_22483619_ChIP-Seq_HELA_Human	1.03436909
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03426092
68	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.01368003
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00548960
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00306742
71	BCAT_22108803_ChIP-Seq_LS180_Human	1.00029509
72	GBX2_23144817_ChIP-Seq_PC3_Human	0.97987286
73	P300_19829295_ChIP-Seq_ESCs_Human	0.97874068
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.97526843
75	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97033205
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97033205
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96549605
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96235676
79	CIITA_25753668_ChIP-Seq_RAJI_Human	0.95303855
80	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.94934449
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94448769
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94063035
83	ERA_21632823_ChIP-Seq_H3396_Human	0.93796901
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93174329
85	MYC_19829295_ChIP-Seq_ESCs_Human	0.92813990
86	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92580672
87	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92218343
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.90127523
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89827968
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89731021
91	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89612174
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89586776
93	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.89582237
94	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.89173006
95	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.86306194
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.85565065
97	CEBPB_22108803_ChIP-Seq_LS180_Human	0.85177719
98	* PHF8_20622853_ChIP-Seq_HELA_Human	0.84734228
99	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.83595997
100	XRN2_22483619_ChIP-Seq_HELA_Human	0.82905486

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.24515559
2	MP0000372_irregular_coat_pigmentation	3.93834285
3	MP0003787_abnormal_imprinting	3.11936134
4	MP0008877_abnormal_DNA_methylation	2.77929682
5	MP0008058_abnormal_DNA_repair	2.67546416
6	MP0005646_abnormal_pituitary_gland	2.57357787
7	MP0004147_increased_porphyrin_level	2.56554115
8	MP0002735_abnormal_chemical_nociception	2.53963018
9	MP0002102_abnormal_ear_morphology	2.36786389
10	MP0008995_early_reproductive_senescence	2.36703427
11	MP0002736_abnormal_nociception_after	2.27111325
12	MP0002938_white_spotting	2.24430587
13	MP0001968_abnormal_touch/_nociception	2.23759804
14	MP0005645_abnormal_hypothalamus_physiol	2.21346228
15	MP0005360_urolithiasis	2.13334624
16	MP0005551_abnormal_eye_electrophysiolog	2.06849200
17	MP0006276_abnormal_autonomic_nervous	1.98732429
18	MP0003121_genomic_imprinting	1.89897037
19	MP0008875_abnormal_xenobiotic_pharmacok	1.84907167
20	MP0005075_abnormal_melanosome_morpholog	1.83514561
21	MP0008872_abnormal_physiological_respon	1.76653387
22	MP0004133_heterotaxia	1.73480892
23	MP0003950_abnormal_plasma_membrane	1.73101899
24	MP0002876_abnormal_thyroid_physiology	1.72972053
25	MP0005171_absent_coat_pigmentation	1.69009737
26	MP0002638_abnormal_pupillary_reflex	1.65436927
27	MP0003786_premature_aging	1.63838008
28	MP0010094_abnormal_chromosome_stability	1.60201258
29	MP0003646_muscle_fatigue	1.57118109
30	MP0003195_calcinosis	1.56406730
31	MP0002733_abnormal_thermal_nociception	1.54672945
32	MP0001873_stomach_inflammation	1.54006267
33	MP0002837_dystrophic_cardiac_calcinosis	1.53917186
34	MP0008057_abnormal_DNA_replication	1.53902912
35	MP0001529_abnormal_vocalization	1.52830867
36	MP0002160_abnormal_reproductive_system	1.52674639
37	MP0004885_abnormal_endolymph	1.52212505
38	MP0001905_abnormal_dopamine_level	1.44441347
39	MP0004142_abnormal_muscle_tone	1.37423634
40	MP0003183_abnormal_peptide_metabolism	1.37293513
41	MP0009765_abnormal_xenobiotic_induced	1.31778790
42	MP0001984_abnormal_olfaction	1.28325919
43	MP0001764_abnormal_homeostasis	1.27402147
44	MP0005389_reproductive_system_phenotype	1.26344042
45	MP0005332_abnormal_amino_acid	1.26337093
46	MP0006072_abnormal_retinal_apoptosis	1.24318175
47	MP0001485_abnormal_pinna_reflex	1.24047708
48	MP0005410_abnormal_fertilization	1.23346221
49	MP0003693_abnormal_embryo_hatching	1.23339291
50	MP0009697_abnormal_copulation	1.21621442
51	MP0005647_abnormal_sex_gland	1.21413639
52	MP0009046_muscle_twitch	1.21298778
53	MP0002734_abnormal_mechanical_nocicepti	1.19137433
54	MP0006036_abnormal_mitochondrial_physio	1.15912737
55	MP0005167_abnormal_blood-brain_barrier	1.13880553
56	MP0008789_abnormal_olfactory_epithelium	1.12547340
57	MP0000631_abnormal_neuroendocrine_gland	1.11171175
58	MP0006292_abnormal_olfactory_placode	1.10690883
59	MP0003718_maternal_effect	1.10290937
60	MP0003724_increased_susceptibility_to	1.08595214
61	MP0002572_abnormal_emotion/affect_behav	1.08126192
62	MP0001970_abnormal_pain_threshold	1.03546075
63	MP0005253_abnormal_eye_physiology	1.03494484
64	MP0009745_abnormal_behavioral_response	1.03012225
65	MP0005266_abnormal_metabolism	1.01076282
66	MP0001502_abnormal_circadian_rhythm	1.00936332
67	MP0002095_abnormal_skin_pigmentation	1.00040216
68	MP0002272_abnormal_nervous_system	0.98739139
69	MP0003111_abnormal_nucleus_morphology	0.97880069
70	MP0002909_abnormal_adrenal_gland	0.97878036
71	MP0001986_abnormal_taste_sensitivity	0.97738922
72	MP0002148_abnormal_hypersensitivity_rea	0.91866354
73	MP0001929_abnormal_gametogenesis	0.90108762
74	MP0003122_maternal_imprinting	0.89827984
75	MP0005671_abnormal_response_to	0.87518426
76	MP0002163_abnormal_gland_morphology	0.87350409
77	MP0003698_abnormal_male_reproductive	0.87031187
78	MP0001919_abnormal_reproductive_system	0.81250905
79	MP0004019_abnormal_vitamin_homeostasis	0.80806134
80	MP0002210_abnormal_sex_determination	0.80461030
81	MP0002067_abnormal_sensory_capabilities	0.79462432
82	MP0003638_abnormal_response/metabolism_	0.76719762
83	MP0002229_neurodegeneration	0.75498062
84	MP0003136_yellow_coat_color	0.74096189
85	MP0001963_abnormal_hearing_physiology	0.73237106
86	MP0003123_paternal_imprinting	0.73004219
87	MP0003879_abnormal_hair_cell	0.72187006
88	MP0000013_abnormal_adipose_tissue	0.70748165
89	MP0005379_endocrine/exocrine_gland_phen	0.70347940
90	MP0004742_abnormal_vestibular_system	0.70095775
91	MP0005084_abnormal_gallbladder_morpholo	0.69232752
92	MP0001486_abnormal_startle_reflex	0.69168845
93	MP0000371_diluted_coat_color	0.68978894
94	MP0000427_abnormal_hair_cycle	0.67324736
95	MP0005636_abnormal_mineral_homeostasis	0.66364539
96	MP0005499_abnormal_olfactory_system	0.66102604
97	MP0005394_taste/olfaction_phenotype	0.66102604
98	MP0000653_abnormal_sex_gland	0.65377873
99	MP0006035_abnormal_mitochondrial_morpho	0.63670358
100	MP0002557_abnormal_social/conspecific_i	0.63304340

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.98002823
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.92378738
3	Abnormality of alanine metabolism (HP:0010916)	3.92378738
4	Hyperalaninemia (HP:0003348)	3.92378738
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.79237912
6	Mitochondrial inheritance (HP:0001427)	3.59766457
7	Acute encephalopathy (HP:0006846)	3.50893792
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.48245986
9	Congenital stationary night blindness (HP:0007642)	3.38046757
10	Increased CSF lactate (HP:0002490)	3.28005587
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.20186923
12	Progressive macrocephaly (HP:0004481)	3.16713447
13	Pancreatic fibrosis (HP:0100732)	3.07558169
14	Congenital sensorineural hearing impairment (HP:0008527)	2.98607193
15	Reticulocytopenia (HP:0001896)	2.95975897
16	Constricted visual fields (HP:0001133)	2.89689922
17	Pancreatic cysts (HP:0001737)	2.87466307
18	Autoimmune thrombocytopenia (HP:0001973)	2.86670403
19	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.86173163
20	Hepatocellular necrosis (HP:0001404)	2.76728295
21	Pendular nystagmus (HP:0012043)	2.76172295
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.68020837
23	Cerebral edema (HP:0002181)	2.64458713
24	Tubulointerstitial nephritis (HP:0001970)	2.62540997
25	Chromsome breakage (HP:0040012)	2.60491488
26	Increased serum lactate (HP:0002151)	2.59331381
27	Abnormality of the renal collecting system (HP:0004742)	2.59173418
28	Short tibia (HP:0005736)	2.58881547
29	Abnormality of the labia minora (HP:0012880)	2.55953226
30	Attenuation of retinal blood vessels (HP:0007843)	2.54870426
31	True hermaphroditism (HP:0010459)	2.52429180
32	Nephronophthisis (HP:0000090)	2.51731046
33	Hepatic necrosis (HP:0002605)	2.50716229
34	Molar tooth sign on MRI (HP:0002419)	2.50650291
35	Abnormality of midbrain morphology (HP:0002418)	2.50650291
36	Asplenia (HP:0001746)	2.48373384
37	Abnormal number of erythroid precursors (HP:0012131)	2.45534723
38	Renal cortical cysts (HP:0000803)	2.43610209
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36622091
40	Neutropenia (HP:0001875)	2.33489901
41	Duplicated collecting system (HP:0000081)	2.33178242
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.32814385
43	Abnormality of T cell physiology (HP:0011840)	2.32426866
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31563053
45	IgG deficiency (HP:0004315)	2.27675549
46	Lactic acidosis (HP:0003128)	2.26631469
47	Lipid accumulation in hepatocytes (HP:0006561)	2.22570082
48	Generalized aminoaciduria (HP:0002909)	2.21459243
49	Absent thumb (HP:0009777)	2.21019292
50	Type II lissencephaly (HP:0007260)	2.20624811
51	Type I transferrin isoform profile (HP:0003642)	2.15499063
52	Abnormality of pyrimidine metabolism (HP:0004353)	2.15431340
53	3-Methylglutaconic aciduria (HP:0003535)	2.12209281
54	Elevated erythrocyte sedimentation rate (HP:0003565)	2.11648362
55	Lethargy (HP:0001254)	2.10861575
56	Abnormality of the renal cortex (HP:0011035)	2.06420432
57	Renal Fanconi syndrome (HP:0001994)	2.05046580
58	Abolished electroretinogram (ERG) (HP:0000550)	2.02522410
59	Metabolic acidosis (HP:0001942)	1.98256588
60	Autoimmune hemolytic anemia (HP:0001890)	1.95969859
61	Optic disc pallor (HP:0000543)	1.93030440
62	Progressive microcephaly (HP:0000253)	1.92808808
63	Abnormality of the renal medulla (HP:0100957)	1.90883101
64	Polydipsia (HP:0001959)	1.90836982
65	Abnormal drinking behavior (HP:0030082)	1.90836982
66	Abnormality of urine glucose concentration (HP:0011016)	1.89093242
67	Glycosuria (HP:0003076)	1.89093242
68	Tubular atrophy (HP:0000092)	1.87760962
69	Lissencephaly (HP:0001339)	1.86286276
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85837246
71	Respiratory failure (HP:0002878)	1.85075850
72	Stomatitis (HP:0010280)	1.84920248
73	Postaxial foot polydactyly (HP:0001830)	1.84535008
74	Visual hallucinations (HP:0002367)	1.83820760
75	Chronic hepatic failure (HP:0100626)	1.83530603
76	Abnormal protein glycosylation (HP:0012346)	1.83358634
77	Abnormal glycosylation (HP:0012345)	1.83358634
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.83358634
79	Abnormal protein N-linked glycosylation (HP:0012347)	1.83358634
80	Concave nail (HP:0001598)	1.80630687
81	Prostate neoplasm (HP:0100787)	1.80288283
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.78516250
83	Abnormality of DNA repair (HP:0003254)	1.75327232
84	Abnormality of serum amino acid levels (HP:0003112)	1.74785860
85	Abnormality of cochlea (HP:0000375)	1.74698096
86	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.74462822
87	Oligohydramnios (HP:0001562)	1.71952199
88	Increased hepatocellular lipid droplets (HP:0006565)	1.70400766
89	Abnormality of the ileum (HP:0001549)	1.69777000
90	Sclerocornea (HP:0000647)	1.68385690
91	Polyphagia (HP:0002591)	1.66896744
92	Increased intramyocellular lipid droplets (HP:0012240)	1.66817241
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66661143
94	Rib fusion (HP:0000902)	1.64996073
95	Increased muscle lipid content (HP:0009058)	1.64411048
96	Blindness (HP:0000618)	1.64030907
97	Medial flaring of the eyebrow (HP:0010747)	1.63636972
98	Nephrogenic diabetes insipidus (HP:0009806)	1.63154809
99	Meckel diverticulum (HP:0002245)	1.62940305
100	Hypomagnesemia (HP:0002917)	1.62874132

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.42151653
2	TRIM28	4.29155963
3	FRK	2.59231198
4	VRK2	2.39627532
5	MAP4K2	2.36675223
6	WNK3	2.34917043
7	BCKDK	2.25601462
8	ADRBK2	2.19262895
9	CDC7	2.01818477
10	GRK1	1.97284416
11	MST4	1.91524912
12	PDK2	1.82300292
13	ZAK	1.77142637
14	MAPK13	1.70375641
15	CCNB1	1.69855715
16	TXK	1.58539338
17	MAP4K1	1.56794378
18	STK16	1.54335453
19	STK38L	1.47291710
20	MAP2K7	1.46831211
21	NUAK1	1.45499501
22	GRK6	1.27291915
23	DYRK2	1.25431344
24	DAPK2	1.25268401
25	CSNK1A1L	1.24963956
26	TESK2	1.23867363
27	CSNK1G3	1.19713059
28	CDK19	1.14220408
29	LIMK1	1.13787918
30	NEK1	1.07901346
31	DAPK1	1.04439032
32	TNIK	1.03312135
33	MATK	1.02578456
34	MARK3	0.97758991
35	ERBB3	0.96667485
36	CHEK2	0.96449025
37	CAMKK2	0.95063619
38	PLK2	0.93893272
39	MAP3K11	0.93490079
40	CSNK1G2	0.92136263
41	CDK8	0.88397651
42	PLK1	0.88065904
43	BMPR1B	0.87026306
44	BUB1	0.84815769
45	PRKCI	0.84024514
46	IKBKB	0.82462197
47	ADRBK1	0.81363472
48	MAP3K4	0.79832901
49	CSNK1G1	0.79254691
50	PLK4	0.78726047
51	VRK1	0.78714162
52	CSNK1A1	0.77301181
53	BCR	0.74801180
54	ATR	0.74312619
55	PIM2	0.72309701
56	PINK1	0.71818540
57	OXSR1	0.70959054
58	IRAK4	0.64529288
59	EIF2AK2	0.63905650
60	EIF2AK3	0.63578284
61	MAP2K2	0.62595291
62	TEC	0.62258130
63	PRKCE	0.61150868
64	CAMK2G	0.60921817
65	TNK2	0.60571813
66	PRKCG	0.60192877
67	KDR	0.60159735
68	RPS6KA5	0.59780704
69	CSNK2A1	0.57117893
70	MAP3K12	0.55132939
71	CAMK2A	0.52815361
72	RPS6KB2	0.51893718
73	CAMK2D	0.51723130
74	PIK3CG	0.51487416
75	PRKACA	0.51404768
76	TAF1	0.48822037
77	IKBKE	0.48230443
78	SYK	0.46972334
79	GRK5	0.46929197
80	LYN	0.46310682
81	PRKCA	0.46271494
82	PRKCH	0.45351078
83	CSNK2A2	0.44883261
84	PIM1	0.43755418
85	ALK	0.43651278
86	CSNK1E	0.43556455
87	PLK3	0.43322345
88	MUSK	0.42026693
89	INSRR	0.41440388
90	PRKCQ	0.40041755
91	KIT	0.38756389
92	WNK4	0.36624737
93	CAMK1	0.36436964
94	ACVR1B	0.36318131
95	CHEK1	0.36245412
96	SRPK1	0.34754131
97	MARK1	0.33806354
98	PRKCD	0.33123108
99	MINK1	0.32253551
100	CSNK1D	0.31960201

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.04279898
2	Homologous recombination_Homo sapiens_hsa03440	2.66740819
3	Parkinsons disease_Homo sapiens_hsa05012	2.54351802
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46336180
5	One carbon pool by folate_Homo sapiens_hsa00670	2.24368037
6	Sulfur metabolism_Homo sapiens_hsa00920	2.23546297
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20696396
8	Base excision repair_Homo sapiens_hsa03410	2.20139562
9	Basal transcription factors_Homo sapiens_hsa03022	2.12316287
10	Ribosome_Homo sapiens_hsa03010	2.00613993
11	DNA replication_Homo sapiens_hsa03030	1.99950829
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.99561614
13	Protein export_Homo sapiens_hsa03060	1.97409668
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95638362
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.94908231
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.69046778
17	Proteasome_Homo sapiens_hsa03050	1.68374668
18	Huntingtons disease_Homo sapiens_hsa05016	1.67340445
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.65277557
20	Butanoate metabolism_Homo sapiens_hsa00650	1.65182430
21	Sulfur relay system_Homo sapiens_hsa04122	1.62798972
22	Regulation of autophagy_Homo sapiens_hsa04140	1.61410371
23	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.59369013
24	Phototransduction_Homo sapiens_hsa04744	1.58324188
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.54907426
26	Alzheimers disease_Homo sapiens_hsa05010	1.54290532
27	Mismatch repair_Homo sapiens_hsa03430	1.49716768
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49310100
29	Olfactory transduction_Homo sapiens_hsa04740	1.47818903
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47279663
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.38018728
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37467223
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.34276566
34	Asthma_Homo sapiens_hsa05310	1.33436143
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.33387936
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32554242
37	Histidine metabolism_Homo sapiens_hsa00340	1.31845242
38	RNA polymerase_Homo sapiens_hsa03020	1.31458668
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.27711477
40	RNA degradation_Homo sapiens_hsa03018	1.22989280
41	Primary immunodeficiency_Homo sapiens_hsa05340	1.22184936
42	Renin-angiotensin system_Homo sapiens_hsa04614	1.21344767
43	Peroxisome_Homo sapiens_hsa04146	1.17123595
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.17118922
45	Caffeine metabolism_Homo sapiens_hsa00232	1.14937111
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11379805
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.08655305
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.07224286
49	Spliceosome_Homo sapiens_hsa03040	1.04397750
50	Nicotine addiction_Homo sapiens_hsa05033	1.04260913
51	Purine metabolism_Homo sapiens_hsa00230	1.02630990
52	Fat digestion and absorption_Homo sapiens_hsa04975	1.02310938
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.01050839
54	Retinol metabolism_Homo sapiens_hsa00830	1.00393739
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.99570119
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99041540
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98374877
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97333112
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95559801
60	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.93247612
61	Metabolic pathways_Homo sapiens_hsa01100	0.92312900
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91759687
63	Ether lipid metabolism_Homo sapiens_hsa00565	0.90794392
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90207001
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89469200
66	Taste transduction_Homo sapiens_hsa04742	0.83902198
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83026130
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.81186802
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80249580
70	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78676763
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77451073
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75938509
73	Morphine addiction_Homo sapiens_hsa05032	0.75293725
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73710809
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71956739
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.71082377
77	Propanoate metabolism_Homo sapiens_hsa00640	0.68957208
78	RNA transport_Homo sapiens_hsa03013	0.68277597
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67483781
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65430498
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62485726
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.60977163
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60595454
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59820658
85	Glutathione metabolism_Homo sapiens_hsa00480	0.52739925
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.50379206
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48207926
88	GABAergic synapse_Homo sapiens_hsa04727	0.45567151
89	Galactose metabolism_Homo sapiens_hsa00052	0.42121524
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.41082549
91	Pancreatic secretion_Homo sapiens_hsa04972	0.38303852
92	Other glycan degradation_Homo sapiens_hsa00511	0.37286658
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36442362
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.35490471
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34055766
96	Fatty acid degradation_Homo sapiens_hsa00071	0.32811843
97	mRNA surveillance pathway_Homo sapiens_hsa03015	0.32153940
98	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30666399
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28452578
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.26355370

PPIAL4E

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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