PPIAL4F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.92746473
2ATP synthesis coupled proton transport (GO:0015986)5.75743476
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.75743476
4cell wall macromolecule catabolic process (GO:0016998)5.30671922
5regulation of isotype switching to IgG isotypes (GO:0048302)4.75979833
6chaperone-mediated protein transport (GO:0072321)4.55862749
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.52024472
8cell wall macromolecule metabolic process (GO:0044036)4.40719213
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.40185463
10termination of RNA polymerase III transcription (GO:0006386)4.40185463
11ribosomal small subunit assembly (GO:0000028)4.34157610
12cullin deneddylation (GO:0010388)4.28524998
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.09020050
14regulation of immunoglobulin secretion (GO:0051023)4.08625340
15rRNA modification (GO:0000154)4.03091260
16protein K6-linked ubiquitination (GO:0085020)3.95312513
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.91358869
18proteasome assembly (GO:0043248)3.89093251
19protein deneddylation (GO:0000338)3.82170609
20GTP biosynthetic process (GO:0006183)3.79980766
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.79145038
22water-soluble vitamin biosynthetic process (GO:0042364)3.67475248
23maturation of SSU-rRNA (GO:0030490)3.58736411
24regulation of podosome assembly (GO:0071801)3.57859463
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54541383
26interferon-gamma production (GO:0032609)3.52012384
27protein neddylation (GO:0045116)3.51202572
28protein complex biogenesis (GO:0070271)3.50684880
29positive regulation of isotype switching (GO:0045830)3.50152546
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49411760
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.47920352
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.45844949
33NADH dehydrogenase complex assembly (GO:0010257)3.45844949
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45844949
35positive regulation of DNA recombination (GO:0045911)3.44956441
36electron transport chain (GO:0022900)3.43536769
37respiratory electron transport chain (GO:0022904)3.43486737
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.42694070
39viral transcription (GO:0019083)3.42645415
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.39677427
41translational termination (GO:0006415)3.38339368
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.37743298
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35567592
44regulation of mitotic spindle checkpoint (GO:1903504)3.35567592
45T-helper cell differentiation (GO:0042093)3.35314864
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.35314864
47UTP biosynthetic process (GO:0006228)3.34966910
48GMP metabolic process (GO:0046037)3.33110995
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.31452299
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27387772
51cotranslational protein targeting to membrane (GO:0006613)3.27225866
52regulation of cellular amino acid metabolic process (GO:0006521)3.27085147
53protein localization to kinetochore (GO:0034501)3.26307274
54protein targeting to ER (GO:0045047)3.25201877
55ATP biosynthetic process (GO:0006754)3.24405150
56signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23378220
57signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23378220
58signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23378220
59mitochondrial respiratory chain complex assembly (GO:0033108)3.20489349
60negative regulation of ligase activity (GO:0051352)3.20202139
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20202139
62DNA damage response, detection of DNA damage (GO:0042769)3.16887938
63inner mitochondrial membrane organization (GO:0007007)3.16722345
64pseudouridine synthesis (GO:0001522)3.16701473
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16377283
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16377283
67translation (GO:0006412)3.15777576
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15656426
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14954404
70autophagic vacuole fusion (GO:0000046)3.13179702
71protein localization to endoplasmic reticulum (GO:0070972)3.11828891
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.08106366
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08106366
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06990967
75negative regulation of B cell apoptotic process (GO:0002903)3.03697962
76translational elongation (GO:0006414)3.03421712
77UTP metabolic process (GO:0046051)3.01921456
78ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01716673
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.01276138
80behavioral response to nicotine (GO:0035095)3.01207184
81guanosine-containing compound biosynthetic process (GO:1901070)3.00914619
82mannosylation (GO:0097502)3.00748970
83rRNA methylation (GO:0031167)2.99461181
84regulation of mitochondrial translation (GO:0070129)2.97866231
85T cell differentiation involved in immune response (GO:0002292)2.97006133
86alpha-beta T cell differentiation involved in immune response (GO:0002293)2.97006133
87alpha-beta T cell activation involved in immune response (GO:0002287)2.97006133
88protein targeting to mitochondrion (GO:0006626)2.94434328
89preassembly of GPI anchor in ER membrane (GO:0016254)2.87928696
90positive regulation of organelle assembly (GO:1902117)2.87640259
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85563067
92hydrogen ion transmembrane transport (GO:1902600)2.84686392
93positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.84488593
94translational initiation (GO:0006413)2.83582745
95ribosomal large subunit biogenesis (GO:0042273)2.83021492
96CTP metabolic process (GO:0046036)2.80819844
97CTP biosynthetic process (GO:0006241)2.80819844
98rRNA processing (GO:0006364)2.76487543
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75577212
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75577212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.58421985
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.21410921
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.58526641
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.08588683
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33193658
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11305767
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01737762
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.94814007
9VDR_23849224_ChIP-Seq_CD4+_Human2.93443104
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88244673
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.81692964
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.80492795
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76613517
14ELK1_19687146_ChIP-ChIP_HELA_Human2.76137469
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60636053
16FOXP3_21729870_ChIP-Seq_TREG_Human2.50209298
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47449495
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.26814818
19VDR_22108803_ChIP-Seq_LS180_Human2.26640019
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.19997759
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18116542
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.06699778
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94007141
24DCP1A_22483619_ChIP-Seq_HELA_Human1.89070517
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89049007
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86699116
27MYC_18940864_ChIP-ChIP_HL60_Human1.80577642
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73706912
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72677272
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71335981
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70002367
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69385121
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68805416
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68449754
35TTF2_22483619_ChIP-Seq_HELA_Human1.66182903
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64046025
37ZNF274_21170338_ChIP-Seq_K562_Hela1.62266476
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58686251
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58335461
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56571838
41EWS_26573619_Chip-Seq_HEK293_Human1.52756285
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51342939
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49619394
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47876569
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.42492368
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37739822
47XRN2_22483619_ChIP-Seq_HELA_Human1.36222555
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35070417
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33552458
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28617358
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24754179
52* AR_20517297_ChIP-Seq_VCAP_Human1.23031324
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21277671
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.19601986
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19601986
56GABP_19822575_ChIP-Seq_HepG2_Human1.18990721
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18752315
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17288997
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15985503
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15052615
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15010858
62E2F7_22180533_ChIP-Seq_HELA_Human1.12713125
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07030892
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.07030123
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06567930
66IRF1_19129219_ChIP-ChIP_H3396_Human1.06518274
67FUS_26573619_Chip-Seq_HEK293_Human1.06329055
68NCOR_22424771_ChIP-Seq_293T_Human1.04208601
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03841146
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03202303
71TP53_22573176_ChIP-Seq_HFKS_Human1.03084839
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02362156
73GATA3_26560356_Chip-Seq_TH2_Human1.01505065
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00701005
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00328934
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99948087
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99190982
78TAF15_26573619_Chip-Seq_HEK293_Human0.98524790
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.97183196
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96508583
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94208293
82HTT_18923047_ChIP-ChIP_STHdh_Human0.93201156
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92294915
84NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91978502
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90320289
86ELF5_23300383_ChIP-Seq_T47D_Human0.90269323
87NANOG_19829295_ChIP-Seq_ESCs_Human0.89374619
88SOX2_19829295_ChIP-Seq_ESCs_Human0.89374619
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88810483
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87461690
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86999702
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85817465
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85607078
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84238017
95P53_21459846_ChIP-Seq_SAOS-2_Human0.83934257
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83650152
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80928688
98P300_19829295_ChIP-Seq_ESCs_Human0.79995342
99MYC_19829295_ChIP-Seq_ESCs_Human0.78545979
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77304044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.34366035
2MP0003786_premature_aging2.98318299
3MP0008058_abnormal_DNA_repair2.76641354
4MP0005075_abnormal_melanosome_morpholog2.74583203
5MP0008877_abnormal_DNA_methylation2.63455412
6MP0010386_abnormal_urinary_bladder2.49520996
7MP0001348_abnormal_lacrimal_gland2.40281818
8MP0001853_heart_inflammation2.27356311
9MP0009379_abnormal_foot_pigmentation2.26323334
10MP0008875_abnormal_xenobiotic_pharmacok2.22316872
11MP0008872_abnormal_physiological_respon2.21572507
12MP0006082_CNS_inflammation2.20510640
13MP0005671_abnormal_response_to2.15207606
14MP0001835_abnormal_antigen_presentation2.10296063
15MP0005084_abnormal_gallbladder_morpholo2.10209239
16MP0008789_abnormal_olfactory_epithelium2.05259814
17MP0006072_abnormal_retinal_apoptosis2.02162040
18MP0003806_abnormal_nucleotide_metabolis2.01130426
19MP0001984_abnormal_olfaction1.95713488
20MP0002138_abnormal_hepatobiliary_system1.95267808
21MP0010094_abnormal_chromosome_stability1.91457062
22MP0000465_gastrointestinal_hemorrhage1.86720532
23MP0004957_abnormal_blastocyst_morpholog1.82337086
24MP0002102_abnormal_ear_morphology1.80311073
25MP0002736_abnormal_nociception_after1.67576784
26MP0002234_abnormal_pharynx_morphology1.65148212
27MP0005551_abnormal_eye_electrophysiolog1.60253888
28MP0003866_abnormal_defecation1.55643926
29MP0002837_dystrophic_cardiac_calcinosis1.55085620
30MP0003195_calcinosis1.54844422
31MP0005310_abnormal_salivary_gland1.52901016
32MP0000427_abnormal_hair_cycle1.51458446
33MP0006036_abnormal_mitochondrial_physio1.48204316
34MP0005499_abnormal_olfactory_system1.47810798
35MP0005394_taste/olfaction_phenotype1.47810798
36MP0001873_stomach_inflammation1.46534963
37MP0005083_abnormal_biliary_tract1.45008947
38MP0004043_abnormal_pH_regulation1.43439265
39MP0006035_abnormal_mitochondrial_morpho1.42480420
40MP0004142_abnormal_muscle_tone1.41808868
41MP0002139_abnormal_hepatobiliary_system1.41157490
42MP0009333_abnormal_splenocyte_physiolog1.38755805
43MP0003718_maternal_effect1.38398907
44MP0002148_abnormal_hypersensitivity_rea1.37830774
45MP0003186_abnormal_redox_activity1.35906932
46MP0002095_abnormal_skin_pigmentation1.33198263
47MP0002876_abnormal_thyroid_physiology1.31445543
48MP0002163_abnormal_gland_morphology1.29346004
49MP0004019_abnormal_vitamin_homeostasis1.27311926
50MP0006292_abnormal_olfactory_placode1.24785638
51MP0004145_abnormal_muscle_electrophysio1.23329197
52MP0002277_abnormal_respiratory_mucosa1.21135562
53MP0005085_abnormal_gallbladder_physiolo1.20859379
54MP0002822_catalepsy1.16987123
55MP0005636_abnormal_mineral_homeostasis1.15538287
56MP0004885_abnormal_endolymph1.12381642
57MP0005253_abnormal_eye_physiology1.12319383
58MP0003011_delayed_dark_adaptation1.11065125
59MP0009046_muscle_twitch1.08211946
60MP0001529_abnormal_vocalization1.07858725
61MP0001293_anophthalmia1.07536780
62MP0003693_abnormal_embryo_hatching1.05083181
63MP0001968_abnormal_touch/_nociception1.04737615
64MP0002938_white_spotting1.03449526
65MP0009785_altered_susceptibility_to1.02378141
66MP0000647_abnormal_sebaceous_gland0.99646650
67MP0003724_increased_susceptibility_to0.97258851
68MP0001986_abnormal_taste_sensitivity0.95352623
69MP0005319_abnormal_enzyme/_coenzyme0.93470615
70MP0003252_abnormal_bile_duct0.93137693
71MP0001800_abnormal_humoral_immune0.92209631
72MP0001765_abnormal_ion_homeostasis0.91429824
73MP0005377_hearing/vestibular/ear_phenot0.91039172
74MP0003878_abnormal_ear_physiology0.91039172
75MP0001542_abnormal_bone_strength0.89929169
76MP0005332_abnormal_amino_acid0.88778647
77MP0000372_irregular_coat_pigmentation0.88574086
78MP0000383_abnormal_hair_follicle0.87885497
79MP0003763_abnormal_thymus_physiology0.87074403
80MP0005000_abnormal_immune_tolerance0.86170785
81MP0002272_abnormal_nervous_system0.86049301
82MP0003077_abnormal_cell_cycle0.83085164
83MP0000579_abnormal_nail_morphology0.83020355
84MP0001485_abnormal_pinna_reflex0.81389029
85MP0001501_abnormal_sleep_pattern0.81066094
86MP0009765_abnormal_xenobiotic_induced0.79382789
87MP0002090_abnormal_vision0.78528348
88MP0001764_abnormal_homeostasis0.78472012
89MP0003567_abnormal_fetal_cardiomyocyte0.77934630
90MP0005646_abnormal_pituitary_gland0.77727077
91MP0002229_neurodegeneration0.77536181
92MP0004381_abnormal_hair_follicle0.76876939
93MP0002723_abnormal_immune_serum0.74621402
94MP0005379_endocrine/exocrine_gland_phen0.73320887
95MP0001819_abnormal_immune_cell0.72976316
96MP0000749_muscle_degeneration0.72291210
97MP0001346_abnormal_lacrimal_gland0.72208734
98MP0002420_abnormal_adaptive_immunity0.71954810
99MP0003119_abnormal_digestive_system0.71588675
100MP0009697_abnormal_copulation0.71325436

Predicted human phenotypes

RankGene SetZ-score
1Lipid accumulation in hepatocytes (HP:0006561)4.73914061
2Methylmalonic acidemia (HP:0002912)4.01729374
3Increased hepatocellular lipid droplets (HP:0006565)3.96206977
4Mitochondrial inheritance (HP:0001427)3.93362299
5Acute necrotizing encephalopathy (HP:0006965)3.89075881
6Reticulocytopenia (HP:0001896)3.82513109
7Congenital, generalized hypertrichosis (HP:0004540)3.70012536
8Duplicated collecting system (HP:0000081)3.62488887
9Increased CSF lactate (HP:0002490)3.59277851
10Abnormal number of erythroid precursors (HP:0012131)3.49333572
11Hepatocellular necrosis (HP:0001404)3.48703418
12Abnormality of the renal collecting system (HP:0004742)3.36346549
13Large for gestational age (HP:0001520)3.32227542
14Abnormal mitochondria in muscle tissue (HP:0008316)3.31129658
15Type I transferrin isoform profile (HP:0003642)3.24364260
16Renal Fanconi syndrome (HP:0001994)3.23578337
17Abnormality of cells of the erythroid lineage (HP:0012130)3.22487996
183-Methylglutaconic aciduria (HP:0003535)3.21713419
19Parakeratosis (HP:0001036)3.18098086
20Hepatic necrosis (HP:0002605)3.15757752
21Progressive macrocephaly (HP:0004481)3.15347478
22Acute encephalopathy (HP:0006846)3.15209993
23Microvesicular hepatic steatosis (HP:0001414)3.09896612
24Beaking of vertebral bodies (HP:0004568)3.09679290
25Methylmalonic aciduria (HP:0012120)3.09329766
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.08866629
27Stomatitis (HP:0010280)3.08631244
28Ureteral duplication (HP:0000073)3.03727623
29Pancytopenia (HP:0001876)2.96073916
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.89950755
31Abnormal protein N-linked glycosylation (HP:0012347)2.89950755
32Abnormal protein glycosylation (HP:0012346)2.89950755
33Abnormal glycosylation (HP:0012345)2.89950755
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85687248
35IgG deficiency (HP:0004315)2.85162607
36Cerebral edema (HP:0002181)2.84550541
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.83060512
38Pancreatic cysts (HP:0001737)2.82772166
39Colon cancer (HP:0003003)2.79638624
40Macrocytic anemia (HP:0001972)2.77966639
41Increased serum lactate (HP:0002151)2.72037655
42Pendular nystagmus (HP:0012043)2.69294387
43Exertional dyspnea (HP:0002875)2.56643426
44Sparse eyelashes (HP:0000653)2.55614107
45Congenital primary aphakia (HP:0007707)2.54992401
46Increased muscle lipid content (HP:0009058)2.53880729
47Testicular atrophy (HP:0000029)2.52919650
48Medial flaring of the eyebrow (HP:0010747)2.50515797
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.47827129
50Hyperglycinemia (HP:0002154)2.46711042
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45492369
52Dicarboxylic aciduria (HP:0003215)2.45492369
53Abnormality of vitamin B metabolism (HP:0004340)2.42970402
54Chromsome breakage (HP:0040012)2.41811875
55Gait imbalance (HP:0002141)2.40931734
56Optic disc pallor (HP:0000543)2.40274205
57Abnormality of renal resorption (HP:0011038)2.33053476
58Lethargy (HP:0001254)2.32633726
59Lactic acidosis (HP:0003128)2.29541328
60Abnormality of dental color (HP:0011073)2.28703037
61Nephrogenic diabetes insipidus (HP:0009806)2.28428638
62Hypoplasia of the pons (HP:0012110)2.27457573
63Respiratory difficulties (HP:0002880)2.26666854
64Pancreatic fibrosis (HP:0100732)2.24779044
65Congenital ichthyosiform erythroderma (HP:0007431)2.21973827
66Abnormality of the pons (HP:0007361)2.20040628
67Abnormality of homocysteine metabolism (HP:0010919)2.19942588
68Homocystinuria (HP:0002156)2.19942588
69Increased intramyocellular lipid droplets (HP:0012240)2.19075432
70Attenuation of retinal blood vessels (HP:0007843)2.18365225
71Abnormality of the ileum (HP:0001549)2.16605343
72Abnormal rod and cone electroretinograms (HP:0008323)2.15818969
73Degeneration of anterior horn cells (HP:0002398)2.14900486
74Abnormality of the anterior horn cell (HP:0006802)2.14900486
75Reduced antithrombin III activity (HP:0001976)2.14740117
76Abnormality of methionine metabolism (HP:0010901)2.12181896
77Respiratory failure (HP:0002878)2.11036485
78Meckel diverticulum (HP:0002245)2.10587879
79Abnormality of serum amino acid levels (HP:0003112)2.08893088
80Poor head control (HP:0002421)2.07429995
81Abnormality of serine family amino acid metabolism (HP:0010894)2.06101655
82Abnormality of glycine metabolism (HP:0010895)2.06101655
83True hermaphroditism (HP:0010459)2.01602623
84Increased corneal curvature (HP:0100692)2.00044485
85Keratoconus (HP:0000563)2.00044485
86Abolished electroretinogram (ERG) (HP:0000550)1.99579216
87Exercise intolerance (HP:0003546)1.98153015
88Erythroderma (HP:0001019)1.98134001
89Megaloblastic anemia (HP:0001889)1.96555018
90Absent thumb (HP:0009777)1.94007566
91Abnormality of alanine metabolism (HP:0010916)1.90293381
92Hyperalaninemia (HP:0003348)1.90293381
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90293381
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90207461
95Vaginal atresia (HP:0000148)1.88294754
96Congenital sensorineural hearing impairment (HP:0008527)1.87433524
97Progressive microcephaly (HP:0000253)1.85910876
98CNS demyelination (HP:0007305)1.85550362
99Sclerocornea (HP:0000647)1.84094545
100Aplastic anemia (HP:0001915)1.83404484

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME15.21521888
2TXK4.71795612
3VRK24.71664501
4PBK3.54272313
5MST43.31678052
6ZAK3.06276737
7EIF2AK12.93144255
8STK162.54897945
9VRK12.34570409
10SRPK12.17852357
11NUAK12.02213597
12GRK72.01599307
13WNK42.01487627
14EIF2AK31.77314353
15ADRBK21.72276038
16BUB11.65655431
17BMPR1B1.56289345
18GRK51.53267588
19ACVR1B1.44349742
20TLK11.41329409
21BCKDK1.39073017
22PLK41.38514387
23NEK11.38008576
24MOS1.37193999
25PDK21.31505736
26EIF2AK21.31363806
27GRK11.31317525
28PASK1.25962885
29PLK31.23854456
30MAP3K41.14607464
31LMTK21.13158919
32STK101.11490118
33TAF11.07093406
34MAP3K121.04735992
35ITK1.04735927
36OXSR11.04574078
37DAPK10.97986427
38FES0.95863926
39IRAK40.93548430
40TAOK30.93072408
41MAP4K20.92633142
42MAP2K60.89914462
43IKBKB0.89633298
44NEK20.85140350
45TGFBR20.84912985
46WNK30.81022787
47MAP2K20.79989003
48TEC0.79855196
49ADRBK10.79500707
50INSRR0.77612776
51STK390.76409132
52AURKB0.75593756
53PLK10.70554846
54TGFBR10.69897548
55TNIK0.68628542
56TSSK60.68450805
57KIT0.68121853
58BRSK20.67668249
59PAK40.64639201
60FRK0.59233827
61MYLK0.58555923
62PINK10.56791391
63TTK0.56130581
64MKNK10.54722725
65ATR0.54436285
66STK38L0.48217873
67CDC70.48090769
68TRIM280.46018951
69MATK0.43115945
70AURKA0.42754854
71IGF1R0.41512780
72MST1R0.40790236
73DAPK20.40591862
74MELK0.40196526
75PRKCQ0.37786783
76CSNK2A10.37717221
77NME20.37296879
78STK40.36798514
79CHEK20.35351633
80CSNK2A20.35331934
81CSF1R0.33525362
82KDR0.33360259
83LYN0.33012419
84DYRK20.32645251
85MKNK20.31540352
86TIE10.31493959
87RPS6KA50.30873153
88MAPKAPK50.30377437
89PIK3CG0.29847140
90CHUK0.29775429
91BRD40.28794064
92PHKG20.28331998
93PHKG10.28331998
94MUSK0.27496917
95RPS6KB20.26625034
96TBK10.26029217
97MAPK130.24485541
98PRKCG0.23755162
99PLK20.22882892
100LIMK10.21975513

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.11740248
2Ribosome_Homo sapiens_hsa030103.69797285
3Oxidative phosphorylation_Homo sapiens_hsa001903.44549890
4RNA polymerase_Homo sapiens_hsa030203.33127739
5Parkinsons disease_Homo sapiens_hsa050122.92844304
6Protein export_Homo sapiens_hsa030602.78261064
7Asthma_Homo sapiens_hsa053102.51968261
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44965635
9Mismatch repair_Homo sapiens_hsa034302.38645936
10Homologous recombination_Homo sapiens_hsa034402.23814193
11DNA replication_Homo sapiens_hsa030302.16675079
12One carbon pool by folate_Homo sapiens_hsa006702.03239196
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02933711
14Allograft rejection_Homo sapiens_hsa053301.97320511
15Huntingtons disease_Homo sapiens_hsa050161.96190099
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.90842475
17Autoimmune thyroid disease_Homo sapiens_hsa053201.89110983
18RNA degradation_Homo sapiens_hsa030181.86582389
19Alzheimers disease_Homo sapiens_hsa050101.78131561
20Pyrimidine metabolism_Homo sapiens_hsa002401.71076563
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67492975
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64816151
23Fanconi anemia pathway_Homo sapiens_hsa034601.56845093
24Spliceosome_Homo sapiens_hsa030401.56117925
25Fatty acid elongation_Homo sapiens_hsa000621.49770173
26Purine metabolism_Homo sapiens_hsa002301.46441680
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44433768
28Basal transcription factors_Homo sapiens_hsa030221.42010901
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41949539
30Base excision repair_Homo sapiens_hsa034101.41707534
31Nucleotide excision repair_Homo sapiens_hsa034201.32251119
32RNA transport_Homo sapiens_hsa030131.30107067
33Phototransduction_Homo sapiens_hsa047441.27605636
34Cardiac muscle contraction_Homo sapiens_hsa042601.27538780
35Peroxisome_Homo sapiens_hsa041461.21075791
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19205507
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08179676
38Graft-versus-host disease_Homo sapiens_hsa053321.00381129
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99098996
40Propanoate metabolism_Homo sapiens_hsa006400.93571214
41Type I diabetes mellitus_Homo sapiens_hsa049400.92380253
42Chemical carcinogenesis_Homo sapiens_hsa052040.89439344
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89329139
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88919043
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88341583
46Tryptophan metabolism_Homo sapiens_hsa003800.85999339
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82611409
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80274342
49Nitrogen metabolism_Homo sapiens_hsa009100.80227972
50Sulfur metabolism_Homo sapiens_hsa009200.75345030
51Linoleic acid metabolism_Homo sapiens_hsa005910.73932475
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.73711786
53Pyruvate metabolism_Homo sapiens_hsa006200.73339709
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.72328324
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72306570
56Butanoate metabolism_Homo sapiens_hsa006500.72056734
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71823198
58Metabolic pathways_Homo sapiens_hsa011000.70666303
59Collecting duct acid secretion_Homo sapiens_hsa049660.68498620
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66569870
61Antigen processing and presentation_Homo sapiens_hsa046120.64755359
62Glutathione metabolism_Homo sapiens_hsa004800.63594259
63Retinol metabolism_Homo sapiens_hsa008300.63561494
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62386416
65Fatty acid degradation_Homo sapiens_hsa000710.61748134
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61192964
67Non-homologous end-joining_Homo sapiens_hsa034500.61034148
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58109152
69Rheumatoid arthritis_Homo sapiens_hsa053230.58025673
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56871686
71Olfactory transduction_Homo sapiens_hsa047400.56762284
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56255412
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52498032
74Arginine and proline metabolism_Homo sapiens_hsa003300.52161555
75Arachidonic acid metabolism_Homo sapiens_hsa005900.51459864
76Folate biosynthesis_Homo sapiens_hsa007900.51075907
77Vitamin B6 metabolism_Homo sapiens_hsa007500.49319618
78Systemic lupus erythematosus_Homo sapiens_hsa053220.47916007
79Caffeine metabolism_Homo sapiens_hsa002320.47760611
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47548391
81Hematopoietic cell lineage_Homo sapiens_hsa046400.47062636
82Fatty acid metabolism_Homo sapiens_hsa012120.46575940
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.42690009
84Vitamin digestion and absorption_Homo sapiens_hsa049770.41240137
85Primary immunodeficiency_Homo sapiens_hsa053400.40036791
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.38898004
87Vibrio cholerae infection_Homo sapiens_hsa051100.37157031
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36041695
89p53 signaling pathway_Homo sapiens_hsa041150.35893893
90Renin-angiotensin system_Homo sapiens_hsa046140.33209333
91Taste transduction_Homo sapiens_hsa047420.33169918
92Epstein-Barr virus infection_Homo sapiens_hsa051690.32694564
93Mineral absorption_Homo sapiens_hsa049780.31487384
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30772869
95Selenocompound metabolism_Homo sapiens_hsa004500.30523600
96Nicotine addiction_Homo sapiens_hsa050330.27818966
97Ether lipid metabolism_Homo sapiens_hsa005650.27777028
98beta-Alanine metabolism_Homo sapiens_hsa004100.22796575
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.22116310
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20837074

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