ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.24088178
2	kynurenine metabolic process (GO:0070189)	4.90381849
3	indole-containing compound catabolic process (GO:0042436)	4.84837776
4	indolalkylamine catabolic process (GO:0046218)	4.84837776
5	tryptophan catabolic process (GO:0006569)	4.84837776
6	indolalkylamine metabolic process (GO:0006586)	4.81257919
7	tryptophan metabolic process (GO:0006568)	4.61599988
8	cellular ketone body metabolic process (GO:0046950)	4.17743682
9	cilium or flagellum-dependent cell motility (GO:0001539)	4.07287386
10	sperm motility (GO:0030317)	4.00497163
11	negative regulation of systemic arterial blood pressure (GO:0003085)	3.89115831
12	primary amino compound metabolic process (GO:1901160)	3.88032022
13	serotonin metabolic process (GO:0042428)	3.83056877
14	indole-containing compound metabolic process (GO:0042430)	3.79686405
15	detection of light stimulus involved in visual perception (GO:0050908)	3.79468017
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.79468017
17	gamma-aminobutyric acid transport (GO:0015812)	3.77354351
18	ketone body metabolic process (GO:1902224)	3.76850290
19	protein polyglutamylation (GO:0018095)	3.76080810
20	NAD biosynthetic process (GO:0009435)	3.72236018
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.69378244
22	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.66186207
23	L-fucose catabolic process (GO:0042355)	3.56756703
24	fucose catabolic process (GO:0019317)	3.56756703
25	L-fucose metabolic process (GO:0042354)	3.56756703
26	regulation of sarcomere organization (GO:0060297)	3.47174676
27	reflex (GO:0060004)	3.43936579
28	regulation of translation, ncRNA-mediated (GO:0045974)	3.41848896
29	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.41848896
30	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.41848896
31	acrosome reaction (GO:0007340)	3.39872044
32	response to pheromone (GO:0019236)	3.38465481
33	multicellular organism reproduction (GO:0032504)	3.38151728
34	sulfation (GO:0051923)	3.37877777
35	signal peptide processing (GO:0006465)	3.36042888
36	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.33374415
37	amine catabolic process (GO:0009310)	3.30290440
38	cellular biogenic amine catabolic process (GO:0042402)	3.30290440
39	epithelial cilium movement (GO:0003351)	3.30031745
40	regulation of hippo signaling (GO:0035330)	3.26089975
41	regulation of posttranscriptional gene silencing (GO:0060147)	3.25374616
42	regulation of gene silencing by miRNA (GO:0060964)	3.25374616
43	regulation of gene silencing by RNA (GO:0060966)	3.25374616
44	establishment of protein localization to Golgi (GO:0072600)	3.24025331
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.22245620
46	membrane depolarization during action potential (GO:0086010)	3.12158307
47	cilium movement (GO:0003341)	3.11891280
48	regulation of female gonad development (GO:2000194)	3.10957282
49	regulation of action potential (GO:0098900)	3.08975472
50	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.02967622
51	protein K48-linked deubiquitination (GO:0071108)	3.00222197
52	response to misfolded protein (GO:0051788)	2.94323108
53	spinal cord motor neuron differentiation (GO:0021522)	2.93630745
54	negative regulation of multicellular organism growth (GO:0040015)	2.88022309
55	photoreceptor cell maintenance (GO:0045494)	2.87245931
56	calcium ion-dependent exocytosis (GO:0017156)	2.86317029
57	axonemal dynein complex assembly (GO:0070286)	2.86240309
58	nonmotile primary cilium assembly (GO:0035058)	2.86089998
59	neuronal action potential (GO:0019228)	2.82224806
60	cAMP catabolic process (GO:0006198)	2.80536975
61	monoubiquitinated protein deubiquitination (GO:0035520)	2.80424547
62	negative regulation of mast cell activation (GO:0033004)	2.79368883
63	positive regulation of cAMP-mediated signaling (GO:0043950)	2.79008878
64	fusion of sperm to egg plasma membrane (GO:0007342)	2.78454622
65	transmission of nerve impulse (GO:0019226)	2.76589766
66	regulation of cilium movement (GO:0003352)	2.76086126
67	axoneme assembly (GO:0035082)	2.75812869
68	behavioral response to ethanol (GO:0048149)	2.75739868
69	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.72796130
70	pyridine nucleotide biosynthetic process (GO:0019363)	2.72796130
71	cilium organization (GO:0044782)	2.70371986
72	protein K11-linked deubiquitination (GO:0035871)	2.68285757
73	protein K63-linked deubiquitination (GO:0070536)	2.65496964
74	cilium assembly (GO:0042384)	2.63777450
75	limb development (GO:0060173)	2.63581734
76	appendage development (GO:0048736)	2.63581734
77	cerebellar Purkinje cell differentiation (GO:0021702)	2.62974950
78	musculoskeletal movement (GO:0050881)	2.62432699
79	multicellular organismal movement (GO:0050879)	2.62432699
80	cell proliferation in forebrain (GO:0021846)	2.60331060
81	flavonoid metabolic process (GO:0009812)	2.59314792
82	synaptic transmission, glutamatergic (GO:0035249)	2.58769370
83	positive regulation of fatty acid oxidation (GO:0046321)	2.58600966
84	aromatic amino acid family catabolic process (GO:0009074)	2.57256931
85	peristalsis (GO:0030432)	2.56176394
86	protein localization to cilium (GO:0061512)	2.55417257
87	regulation of establishment of cell polarity (GO:2000114)	2.55299560
88	snRNA transcription (GO:0009301)	2.55170735
89	opioid receptor signaling pathway (GO:0038003)	2.54863570
90	interkinetic nuclear migration (GO:0022027)	2.54164499
91	benzene-containing compound metabolic process (GO:0042537)	2.53630675
92	neural tube formation (GO:0001841)	2.53315561
93	microtubule severing (GO:0051013)	2.53286842
94	glutamate receptor signaling pathway (GO:0007215)	2.52466078
95	cyclic nucleotide catabolic process (GO:0009214)	2.51959158
96	male meiosis I (GO:0007141)	2.51900146
97	aromatic amino acid family metabolic process (GO:0009072)	2.51267439
98	postsynaptic membrane organization (GO:0001941)	2.49771826
99	startle response (GO:0001964)	2.49677123
100	DNA methylation involved in gamete generation (GO:0043046)	2.48318603

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.14729499
2	VDR_22108803_ChIP-Seq_LS180_Human	3.07343986
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.92069200
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86547870
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46448780
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46222345
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40980137
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.39078731
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23081527
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.11231535
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02993170
12	DROSHA_22980978_ChIP-Seq_HELA_Human	1.94377968
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.82493252
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80069180
15	* ER_23166858_ChIP-Seq_MCF-7_Human	1.77724188
16	P300_19829295_ChIP-Seq_ESCs_Human	1.76276838
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.75611555
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74834775
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.74834775
20	REST_21632747_ChIP-Seq_MESCs_Mouse	1.69669832
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69303873
22	FUS_26573619_Chip-Seq_HEK293_Human	1.68636756
23	STAT3_23295773_ChIP-Seq_U87_Human	1.67463325
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65885020
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.65661876
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.63492898
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62347334
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60902823
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59576117
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.59112291
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58952232
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57627768
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.57522808
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53630018
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52533759
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.50326878
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49443806
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.49443806
39	TCF4_23295773_ChIP-Seq_U87_Human	1.47570499
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46139752
41	AR_25329375_ChIP-Seq_VCAP_Human	1.45626836
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44098240
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42339739
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41896827
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39093582
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36198541
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35678875
48	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.35410229
49	EWS_26573619_Chip-Seq_HEK293_Human	1.35339049
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33463673
51	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32031930
52	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31500378
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31278397
54	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29653320
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26116478
56	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25882052
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24426315
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24221182
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.21722188
60	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.18638598
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17567091
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17469072
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17027064
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16676937
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.16186896
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.15655056
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15544139
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15379453
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14499559
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14499559
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12697652
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11585993
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11585993
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11518475
75	KDM2B_26808549_Chip-Seq_REH_Human	1.11237272
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10452008
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09669308
78	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09407291
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09061401
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07464409
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.07258606
82	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05815025
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05650656
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05550567
85	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05538541
86	* SMAD3_21741376_ChIP-Seq_ESCs_Human	1.05246129
87	TP53_22573176_ChIP-Seq_HFKS_Human	1.05200251
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04802124
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03770215
90	TP53_16413492_ChIP-PET_HCT116_Human	1.03490342
91	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.01842867
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01517203
93	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.01106517
94	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.98563795
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98027384
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97135456
97	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96062561
98	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96048146
99	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.94530479
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94352523

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.42772409
2	MP0003195_calcinosis	2.67859643
3	MP0005410_abnormal_fertilization	2.62658409
4	MP0001968_abnormal_touch/_nociception	2.50064816
5	MP0009745_abnormal_behavioral_response	2.47571424
6	MP0009046_muscle_twitch	2.41534688
7	MP0005551_abnormal_eye_electrophysiolog	2.40450867
8	MP0003646_muscle_fatigue	2.35312209
9	MP0003878_abnormal_ear_physiology	2.30550975
10	MP0005377_hearing/vestibular/ear_phenot	2.30550975
11	MP0001501_abnormal_sleep_pattern	2.26069628
12	MP0001485_abnormal_pinna_reflex	2.18680862
13	MP0002736_abnormal_nociception_after	2.08060840
14	MP0006292_abnormal_olfactory_placode	2.06832244
15	MP0002735_abnormal_chemical_nociception	2.01284342
16	MP0008872_abnormal_physiological_respon	1.94594211
17	MP0002272_abnormal_nervous_system	1.93408793
18	MP0008877_abnormal_DNA_methylation	1.88980145
19	MP0003136_yellow_coat_color	1.77761359
20	MP0001486_abnormal_startle_reflex	1.76167017
21	MP0002064_seizures	1.75076964
22	MP0004142_abnormal_muscle_tone	1.72460608
23	MP0002733_abnormal_thermal_nociception	1.68435315
24	MP0005646_abnormal_pituitary_gland	1.67064289
25	MP0002138_abnormal_hepatobiliary_system	1.66765658
26	MP0005670_abnormal_white_adipose	1.65688903
27	MP0002572_abnormal_emotion/affect_behav	1.65601243
28	MP0005083_abnormal_biliary_tract	1.64271363
29	MP0001970_abnormal_pain_threshold	1.64036721
30	MP0006276_abnormal_autonomic_nervous	1.61871893
31	MP0004742_abnormal_vestibular_system	1.55480021
32	MP0000631_abnormal_neuroendocrine_gland	1.55477818
33	MP0001905_abnormal_dopamine_level	1.54889394
34	MP0000372_irregular_coat_pigmentation	1.52145423
35	MP0003635_abnormal_synaptic_transmissio	1.51530559
36	MP0002557_abnormal_social/conspecific_i	1.49885386
37	MP0002822_catalepsy	1.49397741
38	MP0002653_abnormal_ependyma_morphology	1.47262202
39	MP0001440_abnormal_grooming_behavior	1.44997950
40	MP0002067_abnormal_sensory_capabilities	1.44318500
41	MP0003698_abnormal_male_reproductive	1.43589678
42	MP0004885_abnormal_endolymph	1.42866653
43	MP0002928_abnormal_bile_duct	1.41219736
44	MP0004043_abnormal_pH_regulation	1.39968709
45	MP0005171_absent_coat_pigmentation	1.39910575
46	MP0002102_abnormal_ear_morphology	1.36423694
47	MP0005174_abnormal_tail_pigmentation	1.36216715
48	MP0005423_abnormal_somatic_nervous	1.35964363
49	MP0005253_abnormal_eye_physiology	1.35388076
50	MP0004145_abnormal_muscle_electrophysio	1.34732763
51	MP0001986_abnormal_taste_sensitivity	1.34003868
52	MP0005645_abnormal_hypothalamus_physiol	1.33525935
53	MP0004133_heterotaxia	1.33419901
54	MP0003787_abnormal_imprinting	1.30673659
55	MP0002734_abnormal_mechanical_nocicepti	1.27194886
56	MP0002837_dystrophic_cardiac_calcinosis	1.25787404
57	MP0002063_abnormal_learning/memory/cond	1.20288503
58	MP0003252_abnormal_bile_duct	1.19336971
59	MP0002876_abnormal_thyroid_physiology	1.17509609
60	MP0000026_abnormal_inner_ear	1.16490926
61	MP0002160_abnormal_reproductive_system	1.15475517
62	MP0004130_abnormal_muscle_cell	1.15377265
63	MP0001963_abnormal_hearing_physiology	1.14042306
64	MP0004924_abnormal_behavior	1.13969914
65	MP0005386_behavior/neurological_phenoty	1.13969914
66	MP0003879_abnormal_hair_cell	1.13855292
67	MP0004147_increased_porphyrin_level	1.13606085
68	MP0001348_abnormal_lacrimal_gland	1.11540949
69	MP0003880_abnormal_central_pattern	1.11338486
70	MP0001929_abnormal_gametogenesis	1.09656296
71	MP0001984_abnormal_olfaction	1.08666421
72	MP0000427_abnormal_hair_cycle	1.07931887
73	MP0002938_white_spotting	1.07622850
74	MP0005084_abnormal_gallbladder_morpholo	1.04400279
75	MP0003718_maternal_effect	1.03140877
76	MP0002638_abnormal_pupillary_reflex	1.00948200
77	MP0005389_reproductive_system_phenotype	0.99299620
78	MP0006072_abnormal_retinal_apoptosis	0.98007870
79	MP0003011_delayed_dark_adaptation	0.97844519
80	MP0002229_neurodegeneration	0.95826540
81	MP0000230_abnormal_systemic_arterial	0.95434688
82	MP0002163_abnormal_gland_morphology	0.95432206
83	MP0005195_abnormal_posterior_eye	0.94852163
84	MP0003119_abnormal_digestive_system	0.93315098
85	MP0002752_abnormal_somatic_nervous	0.92734197
86	MP0005379_endocrine/exocrine_gland_phen	0.90543398
87	MP0000049_abnormal_middle_ear	0.88779566
88	MP0000955_abnormal_spinal_cord	0.88717266
89	MP0002210_abnormal_sex_determination	0.87058836
90	MP0010386_abnormal_urinary_bladder	0.86975026
91	MP0002882_abnormal_neuron_morphology	0.81890132
92	MP0000653_abnormal_sex_gland	0.80304314
93	MP0002234_abnormal_pharynx_morphology	0.78448935
94	MP0005310_abnormal_salivary_gland	0.78335275
95	MP0004085_abnormal_heartbeat	0.78246915
96	MP0002184_abnormal_innervation	0.77924374
97	MP0009053_abnormal_anal_canal	0.77757557
98	MP0003137_abnormal_impulse_conducting	0.77220910
99	MP0008961_abnormal_basal_metabolism	0.77056397
100	MP0003633_abnormal_nervous_system	0.76560601

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	6.07213640
2	Progressive cerebellar ataxia (HP:0002073)	5.09976996
3	Pancreatic cysts (HP:0001737)	4.47596478
4	Pancreatic fibrosis (HP:0100732)	4.22466062
5	True hermaphroditism (HP:0010459)	3.94121334
6	Gaze-evoked nystagmus (HP:0000640)	3.79855875
7	Abnormality of midbrain morphology (HP:0002418)	3.66469281
8	Molar tooth sign on MRI (HP:0002419)	3.66469281
9	Nephronophthisis (HP:0000090)	3.64752631
10	Attenuation of retinal blood vessels (HP:0007843)	3.64666027
11	Hyperventilation (HP:0002883)	3.60446575
12	Chronic hepatic failure (HP:0100626)	3.59343256
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.48013350
14	Absent/shortened dynein arms (HP:0200106)	3.48013350
15	Severe visual impairment (HP:0001141)	3.42238054
16	Abolished electroretinogram (ERG) (HP:0000550)	3.38364323
17	Pendular nystagmus (HP:0012043)	3.33408333
18	Congenital stationary night blindness (HP:0007642)	3.22710196
19	Decreased central vision (HP:0007663)	3.19293807
20	Bony spicule pigmentary retinopathy (HP:0007737)	3.13412298
21	Abnormality of the renal medulla (HP:0100957)	3.08563847
22	Cystic liver disease (HP:0006706)	3.00489553
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.92136211
24	Abnormality of the renal cortex (HP:0011035)	2.92098243
25	Congenital sensorineural hearing impairment (HP:0008527)	2.90068080
26	Sclerocornea (HP:0000647)	2.87195030
27	Keratoconus (HP:0000563)	2.85334783
28	Increased corneal curvature (HP:0100692)	2.85334783
29	Protruding tongue (HP:0010808)	2.83446235
30	Type II lissencephaly (HP:0007260)	2.81730719
31	Abnormal ciliary motility (HP:0012262)	2.80207725
32	Abnormal drinking behavior (HP:0030082)	2.68488172
33	Polydipsia (HP:0001959)	2.68488172
34	Medial flaring of the eyebrow (HP:0010747)	2.67540060
35	Clumsiness (HP:0002312)	2.65231046
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.58797996
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.58797996
38	Tubular atrophy (HP:0000092)	2.58458439
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53586861
40	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.52264109
41	Abnormality of binocular vision (HP:0011514)	2.48116085
42	Diplopia (HP:0000651)	2.48116085
43	Abnormality of alanine metabolism (HP:0010916)	2.40805716
44	Hyperalaninemia (HP:0003348)	2.40805716
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40805716
46	Febrile seizures (HP:0002373)	2.38088525
47	Inability to walk (HP:0002540)	2.37341749
48	Retinal dysplasia (HP:0007973)	2.36110561
49	Decreased circulating renin level (HP:0003351)	2.34337564
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.33997281
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.32177155
52	Anencephaly (HP:0002323)	2.26126668
53	Congenital hepatic fibrosis (HP:0002612)	2.25614742
54	Cerebellar dysplasia (HP:0007033)	2.25274400
55	Impaired smooth pursuit (HP:0007772)	2.23521614
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16830432
57	Furrowed tongue (HP:0000221)	2.16663939
58	Focal seizures (HP:0007359)	2.15205884
59	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.12989617
60	Dialeptic seizures (HP:0011146)	2.11111105
61	Gait imbalance (HP:0002141)	2.10920131
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.09952524
63	Congenital, generalized hypertrichosis (HP:0004540)	2.08581324
64	Polyuria (HP:0000103)	2.07023790
65	Hypoplastic ischia (HP:0003175)	2.05746168
66	Male pseudohermaphroditism (HP:0000037)	2.05584190
67	Hypoplasia of the pons (HP:0012110)	2.04336307
68	Absence seizures (HP:0002121)	2.00978755
69	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.00689041
70	Congenital primary aphakia (HP:0007707)	1.99949961
71	Large for gestational age (HP:0001520)	1.98540465
72	Abnormality of macular pigmentation (HP:0008002)	1.97742242
73	Hemiparesis (HP:0001269)	1.97565354
74	Broad-based gait (HP:0002136)	1.96947146
75	Concave nail (HP:0001598)	1.96535906
76	Chorioretinal atrophy (HP:0000533)	1.96360053
77	Agitation (HP:0000713)	1.92720011
78	Genital tract atresia (HP:0001827)	1.92163297
79	Dysmetric saccades (HP:0000641)	1.88448289
80	Postaxial foot polydactyly (HP:0001830)	1.87767778
81	Abnormality of the pons (HP:0007361)	1.86905224
82	Postural instability (HP:0002172)	1.86897467
83	Vaginal atresia (HP:0000148)	1.85539321
84	Retinitis pigmentosa (HP:0000510)	1.84983708
85	Lissencephaly (HP:0001339)	1.84589914
86	Hemiplegia (HP:0002301)	1.82732129
87	Focal motor seizures (HP:0011153)	1.82705028
88	Small hand (HP:0200055)	1.81655682
89	Absent speech (HP:0001344)	1.79698543
90	Hypothermia (HP:0002045)	1.79092441
91	Nephrogenic diabetes insipidus (HP:0009806)	1.78639796
92	Optic nerve hypoplasia (HP:0000609)	1.78557721
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.77836208
94	Abnormal urine output (HP:0012590)	1.75261601
95	Macular degeneration (HP:0000608)	1.74896106
96	Urinary bladder sphincter dysfunction (HP:0002839)	1.73893342
97	Oligodactyly (hands) (HP:0001180)	1.73647043
98	Progressive inability to walk (HP:0002505)	1.72854061
99	Abnormality of the ischium (HP:0003174)	1.72736394
100	Patellar aplasia (HP:0006443)	1.72420980

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.55512536
2	ADRBK2	3.58035305
3	BMPR1B	2.91415146
4	INSRR	2.91315674
5	ACVR1B	2.87449782
6	GRK1	2.59941379
7	CASK	2.32768205
8	ZAK	2.02654838
9	SIK2	1.77675872
10	WNK3	1.75022792
11	TAOK3	1.74860254
12	WNK4	1.70982131
13	MAP3K4	1.69844550
14	OXSR1	1.68370461
15	TLK1	1.67512294
16	PINK1	1.63164438
17	ADRBK1	1.48641801
18	MAP4K2	1.47641251
19	DAPK2	1.47186625
20	NUAK1	1.46771937
21	MAPK13	1.46450554
22	PLK4	1.35444569
23	PTK2B	1.32458866
24	NTRK3	1.28679120
25	PRKCG	1.24384440
26	STK38L	1.20003724
27	TXK	1.17915458
28	MKNK2	1.15619353
29	STK39	1.11933186
30	MAP2K7	1.11479294
31	TNIK	1.10241031
32	PNCK	1.10081576
33	STK38	1.07318598
34	PRKCE	1.07033155
35	TNK2	1.01193654
36	CDK19	0.99941453
37	PAK3	0.88524037
38	MAPK15	0.86782076
39	CAMK1G	0.86421518
40	PRKCH	0.83137106
41	PLK2	0.82593518
42	MARK1	0.80901119
43	NTRK2	0.76295496
44	AKT3	0.75175566
45	TEC	0.74809321
46	PKN1	0.72867838
47	TGFBR1	0.71084699
48	CAMK1D	0.70933040
49	PIK3CG	0.70337299
50	DYRK2	0.68724852
51	CAMKK2	0.68297208
52	CAMK1	0.64094674
53	PRKCQ	0.61450619
54	CAMK2A	0.59980158
55	TIE1	0.59342254
56	PIK3CA	0.59184229
57	SGK2	0.57740528
58	EPHA3	0.56344967
59	PRKAA2	0.54492535
60	STK11	0.53570246
61	VRK1	0.52886526
62	IKBKB	0.52777570
63	WNK1	0.51890947
64	RPS6KA6	0.51527843
65	PRKAA1	0.51184613
66	MAP3K9	0.50961551
67	STK16	0.50610539
68	DDR2	0.50012978
69	MAP3K7	0.49994738
70	PRKCZ	0.49265872
71	ITK	0.49051337
72	CHUK	0.48689090
73	GRK7	0.48089053
74	PRKACA	0.48019814
75	SGK223	0.48007148
76	SGK494	0.48007148
77	MAP2K6	0.47600261
78	PRKCI	0.46641386
79	MAP2K4	0.45020653
80	CAMK4	0.44788118
81	STK3	0.43906671
82	ERBB2	0.43852206
83	SGK1	0.42442593
84	IRAK1	0.42371383
85	PRKCA	0.41226623
86	RPS6KA5	0.40454698
87	MARK3	0.39389853
88	GRK5	0.38743561
89	PRKG1	0.38355809
90	BLK	0.37157448
91	CSNK1A1	0.36990089
92	TYRO3	0.36221207
93	CSNK1G2	0.35205798
94	FER	0.34889372
95	TAF1	0.34351927
96	CSNK1D	0.33228625
97	OBSCN	0.29206344
98	PRKCB	0.28841173
99	NEK2	0.28549664
100	PRKD2	0.28420023

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.11153128
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.66952643
3	Butanoate metabolism_Homo sapiens_hsa00650	2.61349440
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.42691516
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.40624818
6	Phototransduction_Homo sapiens_hsa04744	2.35720063
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22798317
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.21946172
9	Morphine addiction_Homo sapiens_hsa05032	2.16907008
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.16091821
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.11672459
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.07718058
13	Taste transduction_Homo sapiens_hsa04742	2.04054689
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.03784369
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.86327149
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.83019433
17	Olfactory transduction_Homo sapiens_hsa04740	1.77055044
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.76430454
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.76010771
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.74814040
21	ABC transporters_Homo sapiens_hsa02010	1.73586741
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.71995390
23	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.69242622
24	GABAergic synapse_Homo sapiens_hsa04727	1.67969071
25	Circadian entrainment_Homo sapiens_hsa04713	1.52503126
26	Homologous recombination_Homo sapiens_hsa03440	1.51489207
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48222604
28	Serotonergic synapse_Homo sapiens_hsa04726	1.44935721
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40113811
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.39750228
31	Insulin secretion_Homo sapiens_hsa04911	1.32235071
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.25376111
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25126907
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.24448628
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16173839
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16141369
37	Retinol metabolism_Homo sapiens_hsa00830	1.14540617
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07200366
39	Caffeine metabolism_Homo sapiens_hsa00232	1.06781828
40	Salivary secretion_Homo sapiens_hsa04970	1.06219210
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05974071
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04918932
43	Cholinergic synapse_Homo sapiens_hsa04725	1.00902674
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94548277
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.93856364
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93264852
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91479388
48	Gastric acid secretion_Homo sapiens_hsa04971	0.90961741
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90073035
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.87950633
51	RNA polymerase_Homo sapiens_hsa03020	0.86693009
52	Basal transcription factors_Homo sapiens_hsa03022	0.86626457
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86220781
54	Cocaine addiction_Homo sapiens_hsa05030	0.86053510
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.84542381
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84274736
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83348306
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.82170327
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82167954
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.76971225
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75766772
62	Histidine metabolism_Homo sapiens_hsa00340	0.75382855
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75157474
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74443651
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.73375330
66	Long-term depression_Homo sapiens_hsa04730	0.72229530
67	Propanoate metabolism_Homo sapiens_hsa00640	0.64251793
68	Fatty acid degradation_Homo sapiens_hsa00071	0.64024662
69	Peroxisome_Homo sapiens_hsa04146	0.62455385
70	Renin secretion_Homo sapiens_hsa04924	0.61875376
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60895436
72	Huntingtons disease_Homo sapiens_hsa05016	0.59583731
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59239665
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.57035916
75	Alcoholism_Homo sapiens_hsa05034	0.54769581
76	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53159101
77	Regulation of autophagy_Homo sapiens_hsa04140	0.52457286
78	Lysine degradation_Homo sapiens_hsa00310	0.52358099
79	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51028809
80	Sulfur relay system_Homo sapiens_hsa04122	0.49983268
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.49969022
82	Mineral absorption_Homo sapiens_hsa04978	0.48858062
83	Melanoma_Homo sapiens_hsa05218	0.46098827
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46000925
85	Parkinsons disease_Homo sapiens_hsa05012	0.43582527
86	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.41106227
87	MAPK signaling pathway_Homo sapiens_hsa04010	0.39682755
88	Ras signaling pathway_Homo sapiens_hsa04014	0.39297338
89	Alzheimers disease_Homo sapiens_hsa05010	0.38801561
90	Amphetamine addiction_Homo sapiens_hsa05031	0.37947917
91	Purine metabolism_Homo sapiens_hsa00230	0.37436771
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.36687842
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.35524890
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34540918
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.33903713
96	Metabolic pathways_Homo sapiens_hsa01100	0.32574641
97	Bile secretion_Homo sapiens_hsa04976	0.32299933
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.31897062
99	Circadian rhythm_Homo sapiens_hsa04710	0.30853253
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.30252429

PPIAL4G

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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