PPIAL4G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.24088178
2kynurenine metabolic process (GO:0070189)4.90381849
3indole-containing compound catabolic process (GO:0042436)4.84837776
4indolalkylamine catabolic process (GO:0046218)4.84837776
5tryptophan catabolic process (GO:0006569)4.84837776
6indolalkylamine metabolic process (GO:0006586)4.81257919
7tryptophan metabolic process (GO:0006568)4.61599988
8cellular ketone body metabolic process (GO:0046950)4.17743682
9cilium or flagellum-dependent cell motility (GO:0001539)4.07287386
10sperm motility (GO:0030317)4.00497163
11negative regulation of systemic arterial blood pressure (GO:0003085)3.89115831
12primary amino compound metabolic process (GO:1901160)3.88032022
13serotonin metabolic process (GO:0042428)3.83056877
14indole-containing compound metabolic process (GO:0042430)3.79686405
15detection of light stimulus involved in visual perception (GO:0050908)3.79468017
16detection of light stimulus involved in sensory perception (GO:0050962)3.79468017
17gamma-aminobutyric acid transport (GO:0015812)3.77354351
18ketone body metabolic process (GO:1902224)3.76850290
19protein polyglutamylation (GO:0018095)3.76080810
20NAD biosynthetic process (GO:0009435)3.72236018
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.69378244
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66186207
23L-fucose catabolic process (GO:0042355)3.56756703
24fucose catabolic process (GO:0019317)3.56756703
25L-fucose metabolic process (GO:0042354)3.56756703
26regulation of sarcomere organization (GO:0060297)3.47174676
27reflex (GO:0060004)3.43936579
28regulation of translation, ncRNA-mediated (GO:0045974)3.41848896
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41848896
30negative regulation of translation, ncRNA-mediated (GO:0040033)3.41848896
31acrosome reaction (GO:0007340)3.39872044
32response to pheromone (GO:0019236)3.38465481
33multicellular organism reproduction (GO:0032504)3.38151728
34sulfation (GO:0051923)3.37877777
35signal peptide processing (GO:0006465)3.36042888
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33374415
37amine catabolic process (GO:0009310)3.30290440
38cellular biogenic amine catabolic process (GO:0042402)3.30290440
39epithelial cilium movement (GO:0003351)3.30031745
40regulation of hippo signaling (GO:0035330)3.26089975
41regulation of posttranscriptional gene silencing (GO:0060147)3.25374616
42regulation of gene silencing by miRNA (GO:0060964)3.25374616
43regulation of gene silencing by RNA (GO:0060966)3.25374616
44establishment of protein localization to Golgi (GO:0072600)3.24025331
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22245620
46membrane depolarization during action potential (GO:0086010)3.12158307
47cilium movement (GO:0003341)3.11891280
48regulation of female gonad development (GO:2000194)3.10957282
49regulation of action potential (GO:0098900)3.08975472
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02967622
51protein K48-linked deubiquitination (GO:0071108)3.00222197
52response to misfolded protein (GO:0051788)2.94323108
53spinal cord motor neuron differentiation (GO:0021522)2.93630745
54negative regulation of multicellular organism growth (GO:0040015)2.88022309
55photoreceptor cell maintenance (GO:0045494)2.87245931
56calcium ion-dependent exocytosis (GO:0017156)2.86317029
57axonemal dynein complex assembly (GO:0070286)2.86240309
58nonmotile primary cilium assembly (GO:0035058)2.86089998
59neuronal action potential (GO:0019228)2.82224806
60cAMP catabolic process (GO:0006198)2.80536975
61monoubiquitinated protein deubiquitination (GO:0035520)2.80424547
62negative regulation of mast cell activation (GO:0033004)2.79368883
63positive regulation of cAMP-mediated signaling (GO:0043950)2.79008878
64fusion of sperm to egg plasma membrane (GO:0007342)2.78454622
65transmission of nerve impulse (GO:0019226)2.76589766
66regulation of cilium movement (GO:0003352)2.76086126
67axoneme assembly (GO:0035082)2.75812869
68behavioral response to ethanol (GO:0048149)2.75739868
69nicotinamide nucleotide biosynthetic process (GO:0019359)2.72796130
70pyridine nucleotide biosynthetic process (GO:0019363)2.72796130
71cilium organization (GO:0044782)2.70371986
72protein K11-linked deubiquitination (GO:0035871)2.68285757
73protein K63-linked deubiquitination (GO:0070536)2.65496964
74cilium assembly (GO:0042384)2.63777450
75limb development (GO:0060173)2.63581734
76appendage development (GO:0048736)2.63581734
77cerebellar Purkinje cell differentiation (GO:0021702)2.62974950
78musculoskeletal movement (GO:0050881)2.62432699
79multicellular organismal movement (GO:0050879)2.62432699
80cell proliferation in forebrain (GO:0021846)2.60331060
81flavonoid metabolic process (GO:0009812)2.59314792
82synaptic transmission, glutamatergic (GO:0035249)2.58769370
83positive regulation of fatty acid oxidation (GO:0046321)2.58600966
84aromatic amino acid family catabolic process (GO:0009074)2.57256931
85peristalsis (GO:0030432)2.56176394
86protein localization to cilium (GO:0061512)2.55417257
87regulation of establishment of cell polarity (GO:2000114)2.55299560
88snRNA transcription (GO:0009301)2.55170735
89opioid receptor signaling pathway (GO:0038003)2.54863570
90interkinetic nuclear migration (GO:0022027)2.54164499
91benzene-containing compound metabolic process (GO:0042537)2.53630675
92neural tube formation (GO:0001841)2.53315561
93microtubule severing (GO:0051013)2.53286842
94glutamate receptor signaling pathway (GO:0007215)2.52466078
95cyclic nucleotide catabolic process (GO:0009214)2.51959158
96male meiosis I (GO:0007141)2.51900146
97aromatic amino acid family metabolic process (GO:0009072)2.51267439
98postsynaptic membrane organization (GO:0001941)2.49771826
99startle response (GO:0001964)2.49677123
100DNA methylation involved in gamete generation (GO:0043046)2.48318603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14729499
2VDR_22108803_ChIP-Seq_LS180_Human3.07343986
3GBX2_23144817_ChIP-Seq_PC3_Human2.92069200
4ZNF274_21170338_ChIP-Seq_K562_Hela2.86547870
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46448780
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46222345
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40980137
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39078731
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23081527
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11231535
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02993170
12DROSHA_22980978_ChIP-Seq_HELA_Human1.94377968
13TAF15_26573619_Chip-Seq_HEK293_Human1.82493252
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.80069180
15* ER_23166858_ChIP-Seq_MCF-7_Human1.77724188
16P300_19829295_ChIP-Seq_ESCs_Human1.76276838
17AR_21572438_ChIP-Seq_LNCaP_Human1.75611555
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74834775
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.74834775
20REST_21632747_ChIP-Seq_MESCs_Mouse1.69669832
21IGF1R_20145208_ChIP-Seq_DFB_Human1.69303873
22FUS_26573619_Chip-Seq_HEK293_Human1.68636756
23STAT3_23295773_ChIP-Seq_U87_Human1.67463325
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65885020
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65661876
26BCAT_22108803_ChIP-Seq_LS180_Human1.63492898
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62347334
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60902823
29SMAD4_21799915_ChIP-Seq_A2780_Human1.59576117
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59112291
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58952232
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57627768
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57522808
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53630018
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52533759
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50326878
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49443806
38CBP_20019798_ChIP-Seq_JUKART_Human1.49443806
39TCF4_23295773_ChIP-Seq_U87_Human1.47570499
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.46139752
41AR_25329375_ChIP-Seq_VCAP_Human1.45626836
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.44098240
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42339739
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.41896827
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39093582
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.36198541
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35678875
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.35410229
49EWS_26573619_Chip-Seq_HEK293_Human1.35339049
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33463673
51* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32031930
52* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31500378
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.31278397
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.29653320
55IRF1_19129219_ChIP-ChIP_H3396_Human1.26116478
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25882052
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.24426315
58RUNX2_22187159_ChIP-Seq_PCA_Human1.24221182
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21722188
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18638598
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17567091
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17469072
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17027064
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16676937
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16186896
66TCF4_22108803_ChIP-Seq_LS180_Human1.15655056
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.15544139
68RNF2_27304074_Chip-Seq_NSC_Mouse1.15379453
69SOX2_19829295_ChIP-Seq_ESCs_Human1.14499559
70NANOG_19829295_ChIP-Seq_ESCs_Human1.14499559
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12697652
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11585993
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.11585993
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11518475
75KDM2B_26808549_Chip-Seq_REH_Human1.11237272
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10452008
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09669308
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09407291
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09061401
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.07464409
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.07258606
82OCT1_27270436_Chip-Seq_PROSTATE_Human1.05815025
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.05650656
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05550567
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05538541
86* SMAD3_21741376_ChIP-Seq_ESCs_Human1.05246129
87TP53_22573176_ChIP-Seq_HFKS_Human1.05200251
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04802124
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.03770215
90TP53_16413492_ChIP-PET_HCT116_Human1.03490342
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01842867
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01517203
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01106517
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.98563795
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98027384
96AHR_22903824_ChIP-Seq_MCF-7_Human0.97135456
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.96062561
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96048146
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94530479
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.94352523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.42772409
2MP0003195_calcinosis2.67859643
3MP0005410_abnormal_fertilization2.62658409
4MP0001968_abnormal_touch/_nociception2.50064816
5MP0009745_abnormal_behavioral_response2.47571424
6MP0009046_muscle_twitch2.41534688
7MP0005551_abnormal_eye_electrophysiolog2.40450867
8MP0003646_muscle_fatigue2.35312209
9MP0003878_abnormal_ear_physiology2.30550975
10MP0005377_hearing/vestibular/ear_phenot2.30550975
11MP0001501_abnormal_sleep_pattern2.26069628
12MP0001485_abnormal_pinna_reflex2.18680862
13MP0002736_abnormal_nociception_after2.08060840
14MP0006292_abnormal_olfactory_placode2.06832244
15MP0002735_abnormal_chemical_nociception2.01284342
16MP0008872_abnormal_physiological_respon1.94594211
17MP0002272_abnormal_nervous_system1.93408793
18MP0008877_abnormal_DNA_methylation1.88980145
19MP0003136_yellow_coat_color1.77761359
20MP0001486_abnormal_startle_reflex1.76167017
21MP0002064_seizures1.75076964
22MP0004142_abnormal_muscle_tone1.72460608
23MP0002733_abnormal_thermal_nociception1.68435315
24MP0005646_abnormal_pituitary_gland1.67064289
25MP0002138_abnormal_hepatobiliary_system1.66765658
26MP0005670_abnormal_white_adipose1.65688903
27MP0002572_abnormal_emotion/affect_behav1.65601243
28MP0005083_abnormal_biliary_tract1.64271363
29MP0001970_abnormal_pain_threshold1.64036721
30MP0006276_abnormal_autonomic_nervous1.61871893
31MP0004742_abnormal_vestibular_system1.55480021
32MP0000631_abnormal_neuroendocrine_gland1.55477818
33MP0001905_abnormal_dopamine_level1.54889394
34MP0000372_irregular_coat_pigmentation1.52145423
35MP0003635_abnormal_synaptic_transmissio1.51530559
36MP0002557_abnormal_social/conspecific_i1.49885386
37MP0002822_catalepsy1.49397741
38MP0002653_abnormal_ependyma_morphology1.47262202
39MP0001440_abnormal_grooming_behavior1.44997950
40MP0002067_abnormal_sensory_capabilities1.44318500
41MP0003698_abnormal_male_reproductive1.43589678
42MP0004885_abnormal_endolymph1.42866653
43MP0002928_abnormal_bile_duct1.41219736
44MP0004043_abnormal_pH_regulation1.39968709
45MP0005171_absent_coat_pigmentation1.39910575
46MP0002102_abnormal_ear_morphology1.36423694
47MP0005174_abnormal_tail_pigmentation1.36216715
48MP0005423_abnormal_somatic_nervous1.35964363
49MP0005253_abnormal_eye_physiology1.35388076
50MP0004145_abnormal_muscle_electrophysio1.34732763
51MP0001986_abnormal_taste_sensitivity1.34003868
52MP0005645_abnormal_hypothalamus_physiol1.33525935
53MP0004133_heterotaxia1.33419901
54MP0003787_abnormal_imprinting1.30673659
55MP0002734_abnormal_mechanical_nocicepti1.27194886
56MP0002837_dystrophic_cardiac_calcinosis1.25787404
57MP0002063_abnormal_learning/memory/cond1.20288503
58MP0003252_abnormal_bile_duct1.19336971
59MP0002876_abnormal_thyroid_physiology1.17509609
60MP0000026_abnormal_inner_ear1.16490926
61MP0002160_abnormal_reproductive_system1.15475517
62MP0004130_abnormal_muscle_cell1.15377265
63MP0001963_abnormal_hearing_physiology1.14042306
64MP0004924_abnormal_behavior1.13969914
65MP0005386_behavior/neurological_phenoty1.13969914
66MP0003879_abnormal_hair_cell1.13855292
67MP0004147_increased_porphyrin_level1.13606085
68MP0001348_abnormal_lacrimal_gland1.11540949
69MP0003880_abnormal_central_pattern1.11338486
70MP0001929_abnormal_gametogenesis1.09656296
71MP0001984_abnormal_olfaction1.08666421
72MP0000427_abnormal_hair_cycle1.07931887
73MP0002938_white_spotting1.07622850
74MP0005084_abnormal_gallbladder_morpholo1.04400279
75MP0003718_maternal_effect1.03140877
76MP0002638_abnormal_pupillary_reflex1.00948200
77MP0005389_reproductive_system_phenotype0.99299620
78MP0006072_abnormal_retinal_apoptosis0.98007870
79MP0003011_delayed_dark_adaptation0.97844519
80MP0002229_neurodegeneration0.95826540
81MP0000230_abnormal_systemic_arterial0.95434688
82MP0002163_abnormal_gland_morphology0.95432206
83MP0005195_abnormal_posterior_eye0.94852163
84MP0003119_abnormal_digestive_system0.93315098
85MP0002752_abnormal_somatic_nervous0.92734197
86MP0005379_endocrine/exocrine_gland_phen0.90543398
87MP0000049_abnormal_middle_ear0.88779566
88MP0000955_abnormal_spinal_cord0.88717266
89MP0002210_abnormal_sex_determination0.87058836
90MP0010386_abnormal_urinary_bladder0.86975026
91MP0002882_abnormal_neuron_morphology0.81890132
92MP0000653_abnormal_sex_gland0.80304314
93MP0002234_abnormal_pharynx_morphology0.78448935
94MP0005310_abnormal_salivary_gland0.78335275
95MP0004085_abnormal_heartbeat0.78246915
96MP0002184_abnormal_innervation0.77924374
97MP0009053_abnormal_anal_canal0.77757557
98MP0003137_abnormal_impulse_conducting0.77220910
99MP0008961_abnormal_basal_metabolism0.77056397
100MP0003633_abnormal_nervous_system0.76560601

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)6.07213640
2Progressive cerebellar ataxia (HP:0002073)5.09976996
3Pancreatic cysts (HP:0001737)4.47596478
4Pancreatic fibrosis (HP:0100732)4.22466062
5True hermaphroditism (HP:0010459)3.94121334
6Gaze-evoked nystagmus (HP:0000640)3.79855875
7Abnormality of midbrain morphology (HP:0002418)3.66469281
8Molar tooth sign on MRI (HP:0002419)3.66469281
9Nephronophthisis (HP:0000090)3.64752631
10Attenuation of retinal blood vessels (HP:0007843)3.64666027
11Hyperventilation (HP:0002883)3.60446575
12Chronic hepatic failure (HP:0100626)3.59343256
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.48013350
14Absent/shortened dynein arms (HP:0200106)3.48013350
15Severe visual impairment (HP:0001141)3.42238054
16Abolished electroretinogram (ERG) (HP:0000550)3.38364323
17Pendular nystagmus (HP:0012043)3.33408333
18Congenital stationary night blindness (HP:0007642)3.22710196
19Decreased central vision (HP:0007663)3.19293807
20Bony spicule pigmentary retinopathy (HP:0007737)3.13412298
21Abnormality of the renal medulla (HP:0100957)3.08563847
22Cystic liver disease (HP:0006706)3.00489553
23Abnormal rod and cone electroretinograms (HP:0008323)2.92136211
24Abnormality of the renal cortex (HP:0011035)2.92098243
25Congenital sensorineural hearing impairment (HP:0008527)2.90068080
26Sclerocornea (HP:0000647)2.87195030
27Keratoconus (HP:0000563)2.85334783
28Increased corneal curvature (HP:0100692)2.85334783
29Protruding tongue (HP:0010808)2.83446235
30Type II lissencephaly (HP:0007260)2.81730719
31Abnormal ciliary motility (HP:0012262)2.80207725
32Abnormal drinking behavior (HP:0030082)2.68488172
33Polydipsia (HP:0001959)2.68488172
34Medial flaring of the eyebrow (HP:0010747)2.67540060
35Clumsiness (HP:0002312)2.65231046
36Abnormal respiratory epithelium morphology (HP:0012253)2.58797996
37Abnormal respiratory motile cilium morphology (HP:0005938)2.58797996
38Tubular atrophy (HP:0000092)2.58458439
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53586861
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52264109
41Abnormality of binocular vision (HP:0011514)2.48116085
42Diplopia (HP:0000651)2.48116085
43Abnormality of alanine metabolism (HP:0010916)2.40805716
44Hyperalaninemia (HP:0003348)2.40805716
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40805716
46Febrile seizures (HP:0002373)2.38088525
47Inability to walk (HP:0002540)2.37341749
48Retinal dysplasia (HP:0007973)2.36110561
49Decreased circulating renin level (HP:0003351)2.34337564
50Abnormal respiratory motile cilium physiology (HP:0012261)2.33997281
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.32177155
52Anencephaly (HP:0002323)2.26126668
53Congenital hepatic fibrosis (HP:0002612)2.25614742
54Cerebellar dysplasia (HP:0007033)2.25274400
55Impaired smooth pursuit (HP:0007772)2.23521614
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.16830432
57Furrowed tongue (HP:0000221)2.16663939
58Focal seizures (HP:0007359)2.15205884
59Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12989617
60Dialeptic seizures (HP:0011146)2.11111105
61Gait imbalance (HP:0002141)2.10920131
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09952524
63Congenital, generalized hypertrichosis (HP:0004540)2.08581324
64Polyuria (HP:0000103)2.07023790
65Hypoplastic ischia (HP:0003175)2.05746168
66Male pseudohermaphroditism (HP:0000037)2.05584190
67Hypoplasia of the pons (HP:0012110)2.04336307
68Absence seizures (HP:0002121)2.00978755
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.00689041
70Congenital primary aphakia (HP:0007707)1.99949961
71Large for gestational age (HP:0001520)1.98540465
72Abnormality of macular pigmentation (HP:0008002)1.97742242
73Hemiparesis (HP:0001269)1.97565354
74Broad-based gait (HP:0002136)1.96947146
75Concave nail (HP:0001598)1.96535906
76Chorioretinal atrophy (HP:0000533)1.96360053
77Agitation (HP:0000713)1.92720011
78Genital tract atresia (HP:0001827)1.92163297
79Dysmetric saccades (HP:0000641)1.88448289
80Postaxial foot polydactyly (HP:0001830)1.87767778
81Abnormality of the pons (HP:0007361)1.86905224
82Postural instability (HP:0002172)1.86897467
83Vaginal atresia (HP:0000148)1.85539321
84Retinitis pigmentosa (HP:0000510)1.84983708
85Lissencephaly (HP:0001339)1.84589914
86Hemiplegia (HP:0002301)1.82732129
87Focal motor seizures (HP:0011153)1.82705028
88Small hand (HP:0200055)1.81655682
89Absent speech (HP:0001344)1.79698543
90Hypothermia (HP:0002045)1.79092441
91Nephrogenic diabetes insipidus (HP:0009806)1.78639796
92Optic nerve hypoplasia (HP:0000609)1.78557721
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77836208
94Abnormal urine output (HP:0012590)1.75261601
95Macular degeneration (HP:0000608)1.74896106
96Urinary bladder sphincter dysfunction (HP:0002839)1.73893342
97Oligodactyly (hands) (HP:0001180)1.73647043
98Progressive inability to walk (HP:0002505)1.72854061
99Abnormality of the ischium (HP:0003174)1.72736394
100Patellar aplasia (HP:0006443)1.72420980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.55512536
2ADRBK23.58035305
3BMPR1B2.91415146
4INSRR2.91315674
5ACVR1B2.87449782
6GRK12.59941379
7CASK2.32768205
8ZAK2.02654838
9SIK21.77675872
10WNK31.75022792
11TAOK31.74860254
12WNK41.70982131
13MAP3K41.69844550
14OXSR11.68370461
15TLK11.67512294
16PINK11.63164438
17ADRBK11.48641801
18MAP4K21.47641251
19DAPK21.47186625
20NUAK11.46771937
21MAPK131.46450554
22PLK41.35444569
23PTK2B1.32458866
24NTRK31.28679120
25PRKCG1.24384440
26STK38L1.20003724
27TXK1.17915458
28MKNK21.15619353
29STK391.11933186
30MAP2K71.11479294
31TNIK1.10241031
32PNCK1.10081576
33STK381.07318598
34PRKCE1.07033155
35TNK21.01193654
36CDK190.99941453
37PAK30.88524037
38MAPK150.86782076
39CAMK1G0.86421518
40PRKCH0.83137106
41PLK20.82593518
42MARK10.80901119
43NTRK20.76295496
44AKT30.75175566
45TEC0.74809321
46PKN10.72867838
47TGFBR10.71084699
48CAMK1D0.70933040
49PIK3CG0.70337299
50DYRK20.68724852
51CAMKK20.68297208
52CAMK10.64094674
53PRKCQ0.61450619
54CAMK2A0.59980158
55TIE10.59342254
56PIK3CA0.59184229
57SGK20.57740528
58EPHA30.56344967
59PRKAA20.54492535
60STK110.53570246
61VRK10.52886526
62IKBKB0.52777570
63WNK10.51890947
64RPS6KA60.51527843
65PRKAA10.51184613
66MAP3K90.50961551
67STK160.50610539
68DDR20.50012978
69MAP3K70.49994738
70PRKCZ0.49265872
71ITK0.49051337
72CHUK0.48689090
73GRK70.48089053
74PRKACA0.48019814
75SGK2230.48007148
76SGK4940.48007148
77MAP2K60.47600261
78PRKCI0.46641386
79MAP2K40.45020653
80CAMK40.44788118
81STK30.43906671
82ERBB20.43852206
83SGK10.42442593
84IRAK10.42371383
85PRKCA0.41226623
86RPS6KA50.40454698
87MARK30.39389853
88GRK50.38743561
89PRKG10.38355809
90BLK0.37157448
91CSNK1A10.36990089
92TYRO30.36221207
93CSNK1G20.35205798
94FER0.34889372
95TAF10.34351927
96CSNK1D0.33228625
97OBSCN0.29206344
98PRKCB0.28841173
99NEK20.28549664
100PRKD20.28420023

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11153128
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.66952643
3Butanoate metabolism_Homo sapiens_hsa006502.61349440
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42691516
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.40624818
6Phototransduction_Homo sapiens_hsa047442.35720063
7Linoleic acid metabolism_Homo sapiens_hsa005912.22798317
8Selenocompound metabolism_Homo sapiens_hsa004502.21946172
9Morphine addiction_Homo sapiens_hsa050322.16907008
10Tryptophan metabolism_Homo sapiens_hsa003802.16091821
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11672459
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07718058
13Taste transduction_Homo sapiens_hsa047422.04054689
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.03784369
15Nitrogen metabolism_Homo sapiens_hsa009101.86327149
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.83019433
17Olfactory transduction_Homo sapiens_hsa047401.77055044
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76430454
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76010771
20Glutamatergic synapse_Homo sapiens_hsa047241.74814040
21ABC transporters_Homo sapiens_hsa020101.73586741
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71995390
23Fatty acid biosynthesis_Homo sapiens_hsa000611.69242622
24GABAergic synapse_Homo sapiens_hsa047271.67969071
25Circadian entrainment_Homo sapiens_hsa047131.52503126
26Homologous recombination_Homo sapiens_hsa034401.51489207
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.48222604
28Serotonergic synapse_Homo sapiens_hsa047261.44935721
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40113811
30Ether lipid metabolism_Homo sapiens_hsa005651.39750228
31Insulin secretion_Homo sapiens_hsa049111.32235071
32Calcium signaling pathway_Homo sapiens_hsa040201.25376111
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25126907
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24448628
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16173839
36Chemical carcinogenesis_Homo sapiens_hsa052041.16141369
37Retinol metabolism_Homo sapiens_hsa008301.14540617
38Glycerolipid metabolism_Homo sapiens_hsa005611.07200366
39Caffeine metabolism_Homo sapiens_hsa002321.06781828
40Salivary secretion_Homo sapiens_hsa049701.06219210
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.05974071
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04918932
43Cholinergic synapse_Homo sapiens_hsa047251.00902674
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94548277
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.93856364
46beta-Alanine metabolism_Homo sapiens_hsa004100.93264852
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91479388
48Gastric acid secretion_Homo sapiens_hsa049710.90961741
49Fanconi anemia pathway_Homo sapiens_hsa034600.90073035
50Dorso-ventral axis formation_Homo sapiens_hsa043200.87950633
51RNA polymerase_Homo sapiens_hsa030200.86693009
52Basal transcription factors_Homo sapiens_hsa030220.86626457
53Ovarian steroidogenesis_Homo sapiens_hsa049130.86220781
54Cocaine addiction_Homo sapiens_hsa050300.86053510
55cAMP signaling pathway_Homo sapiens_hsa040240.84542381
56Arachidonic acid metabolism_Homo sapiens_hsa005900.84274736
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83348306
58Oxidative phosphorylation_Homo sapiens_hsa001900.82170327
59Hedgehog signaling pathway_Homo sapiens_hsa043400.82167954
60Type II diabetes mellitus_Homo sapiens_hsa049300.76971225
61Cardiac muscle contraction_Homo sapiens_hsa042600.75766772
62Histidine metabolism_Homo sapiens_hsa003400.75382855
63Oxytocin signaling pathway_Homo sapiens_hsa049210.75157474
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74443651
65Dopaminergic synapse_Homo sapiens_hsa047280.73375330
66Long-term depression_Homo sapiens_hsa047300.72229530
67Propanoate metabolism_Homo sapiens_hsa006400.64251793
68Fatty acid degradation_Homo sapiens_hsa000710.64024662
69Peroxisome_Homo sapiens_hsa041460.62455385
70Renin secretion_Homo sapiens_hsa049240.61875376
71Systemic lupus erythematosus_Homo sapiens_hsa053220.60895436
72Huntingtons disease_Homo sapiens_hsa050160.59583731
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.59239665
74Basal cell carcinoma_Homo sapiens_hsa052170.57035916
75Alcoholism_Homo sapiens_hsa050340.54769581
76Vitamin digestion and absorption_Homo sapiens_hsa049770.53159101
77Regulation of autophagy_Homo sapiens_hsa041400.52457286
78Lysine degradation_Homo sapiens_hsa003100.52358099
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51028809
80Sulfur relay system_Homo sapiens_hsa041220.49983268
81Fat digestion and absorption_Homo sapiens_hsa049750.49969022
82Mineral absorption_Homo sapiens_hsa049780.48858062
83Melanoma_Homo sapiens_hsa052180.46098827
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46000925
85Parkinsons disease_Homo sapiens_hsa050120.43582527
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41106227
87MAPK signaling pathway_Homo sapiens_hsa040100.39682755
88Ras signaling pathway_Homo sapiens_hsa040140.39297338
89Alzheimers disease_Homo sapiens_hsa050100.38801561
90Amphetamine addiction_Homo sapiens_hsa050310.37947917
91Purine metabolism_Homo sapiens_hsa002300.37436771
92Synaptic vesicle cycle_Homo sapiens_hsa047210.36687842
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35524890
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.34540918
95Primary immunodeficiency_Homo sapiens_hsa053400.33903713
96Metabolic pathways_Homo sapiens_hsa011000.32574641
97Bile secretion_Homo sapiens_hsa049760.32299933
98Fatty acid metabolism_Homo sapiens_hsa012120.31897062
99Circadian rhythm_Homo sapiens_hsa047100.30853253
100PPAR signaling pathway_Homo sapiens_hsa033200.30252429

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