PPIAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transmission of nerve impulse (GO:0051969)6.12259716
2behavioral response to nicotine (GO:0035095)5.37317148
3DNA deamination (GO:0045006)4.88641621
4ovulation cycle (GO:0042698)4.29206828
5retinal cone cell development (GO:0046549)4.15405909
6peptidyl-histidine modification (GO:0018202)4.10742482
7negative regulation of neurological system process (GO:0031645)4.07275877
8positive regulation of neurological system process (GO:0031646)4.00702599
9regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.96460963
10head development (GO:0060322)3.96437674
11tyrosine phosphorylation of STAT protein (GO:0007260)3.94447252
12establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.78693543
13mitochondrion transport along microtubule (GO:0047497)3.78693543
14ATP synthesis coupled proton transport (GO:0015986)3.75830309
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75830309
16apoptotic DNA fragmentation (GO:0006309)3.74563349
17negative regulation of protein tyrosine kinase activity (GO:0061099)3.69856148
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58595701
19regulation of T-helper 1 cell differentiation (GO:0045625)3.58125872
20establishment of mitochondrion localization (GO:0051654)3.54884573
21amine catabolic process (GO:0009310)3.51250511
22cellular biogenic amine catabolic process (GO:0042402)3.51250511
23fucose catabolic process (GO:0019317)3.50269574
24L-fucose metabolic process (GO:0042354)3.50269574
25L-fucose catabolic process (GO:0042355)3.50269574
26tryptophan catabolic process (GO:0006569)3.42406511
27indole-containing compound catabolic process (GO:0042436)3.42406511
28indolalkylamine catabolic process (GO:0046218)3.42406511
29regulation of female gonad development (GO:2000194)3.41357605
30ribonucleoprotein complex disassembly (GO:0032988)3.34565018
31response to pheromone (GO:0019236)3.34197909
32nucleotide transmembrane transport (GO:1901679)3.32612305
33signal peptide processing (GO:0006465)3.32210775
34negative regulation of telomere maintenance (GO:0032205)3.26058043
35detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.24198883
36organelle disassembly (GO:1903008)3.22617819
37cellular ketone body metabolic process (GO:0046950)3.21148684
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20839875
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19696323
40regulation of bile acid biosynthetic process (GO:0070857)3.16363270
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15415933
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15415933
43kidney morphogenesis (GO:0060993)3.12753100
44positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.03035192
45negative regulation of T cell differentiation in thymus (GO:0033085)3.00511317
46regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.00265881
47rRNA catabolic process (GO:0016075)3.00115688
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99354272
49heart field specification (GO:0003128)2.97957208
50secondary heart field specification (GO:0003139)2.97957208
51positive regulation of cAMP-mediated signaling (GO:0043950)2.95067765
52negative regulation of DNA-dependent DNA replication (GO:2000104)2.92500142
53positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.92123850
54calcium ion-dependent exocytosis (GO:0017156)2.91764423
55regulation of thymocyte apoptotic process (GO:0070243)2.87941669
56ketone body metabolic process (GO:1902224)2.82407522
57acrosome assembly (GO:0001675)2.81966350
58negative regulation of execution phase of apoptosis (GO:1900118)2.81813856
59detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.78054690
60platelet dense granule organization (GO:0060155)2.77418783
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76563242
62negative regulation of mast cell activation (GO:0033004)2.75980282
63regulation of cilium movement (GO:0003352)2.75528640
64photoreceptor cell maintenance (GO:0045494)2.72760172
65endoderm formation (GO:0001706)2.72254448
66regulation of cytokine production involved in inflammatory response (GO:1900015)2.71604488
67tryptophan metabolic process (GO:0006568)2.71281346
68lysosome localization (GO:0032418)2.69997828
69cell fate commitment involved in formation of primary germ layer (GO:0060795)2.66371488
70thyroid hormone generation (GO:0006590)2.66317271
71transcription elongation from RNA polymerase I promoter (GO:0006362)2.65789949
72meiotic chromosome segregation (GO:0045132)2.65469002
73ubiquinone biosynthetic process (GO:0006744)2.64431534
74pyrimidine nucleobase catabolic process (GO:0006208)2.64364414
75postsynaptic membrane organization (GO:0001941)2.63744043
76resolution of meiotic recombination intermediates (GO:0000712)2.62175589
77positive regulation of gastrulation (GO:2000543)2.61811205
78indolalkylamine metabolic process (GO:0006586)2.61376288
79cellular response to zinc ion (GO:0071294)2.61227374
80negative regulation of potassium ion transport (GO:0043267)2.60184239
81centriole replication (GO:0007099)2.60108167
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.56538712
83cellular response to interferon-beta (GO:0035458)2.56061323
84inner ear receptor cell differentiation (GO:0060113)2.55894121
85synaptic transmission, cholinergic (GO:0007271)2.54013784
86pancreas development (GO:0031016)2.53475736
87nucleobase catabolic process (GO:0046113)2.51552294
88genetic imprinting (GO:0071514)2.50772047
89microtubule nucleation (GO:0007020)2.50235537
90cellular response to ATP (GO:0071318)2.47222275
91mast cell activation involved in immune response (GO:0002279)2.45564894
92mast cell degranulation (GO:0043303)2.45564894
93thyroid hormone metabolic process (GO:0042403)2.45486401
94tRNA processing (GO:0008033)2.45450564
95regulation of meiosis I (GO:0060631)2.44308220
96sulfate transport (GO:0008272)2.43856413
97positive regulation of sodium ion transmembrane transport (GO:1902307)2.43712799
98cerebellar Purkinje cell differentiation (GO:0021702)2.42622341
99pseudouridine synthesis (GO:0001522)2.41886081
100photoreceptor cell development (GO:0042461)2.41023129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.51297728
2VDR_22108803_ChIP-Seq_LS180_Human4.22469178
3ZNF274_21170338_ChIP-Seq_K562_Hela3.05269953
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.40641925
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.23428544
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10054637
7EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.08277349
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.04733317
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.03462333
10GABP_17652178_ChIP-ChIP_JURKAT_Human1.92480118
11TP53_22573176_ChIP-Seq_HFKS_Human1.85950190
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78380754
13GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.76868348
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74975551
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74262578
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71844489
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67727672
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66500337
19ER_23166858_ChIP-Seq_MCF-7_Human1.65690425
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57577911
21FUS_26573619_Chip-Seq_HEK293_Human1.57556050
22REST_21632747_ChIP-Seq_MESCs_Mouse1.56361121
23P300_19829295_ChIP-Seq_ESCs_Human1.56067809
24NANOG_19829295_ChIP-Seq_ESCs_Human1.54951425
25SOX2_19829295_ChIP-Seq_ESCs_Human1.54951425
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.52866092
27IRF1_19129219_ChIP-ChIP_H3396_Human1.51985255
28ETV2_25802403_ChIP-Seq_MESCs_Mouse1.51498687
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50450511
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48056833
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47289962
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46891072
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46668545
34TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.42497922
35VDR_23849224_ChIP-Seq_CD4+_Human1.41795564
36TAF15_26573619_Chip-Seq_HEK293_Human1.41255309
37HOXB7_26014856_ChIP-Seq_BT474_Human1.41192841
38LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39300977
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.38472013
40ETV1_20927104_ChIP-Seq_GIST48_Human1.37408943
41IGF1R_20145208_ChIP-Seq_DFB_Human1.37149713
42NCOR_22424771_ChIP-Seq_293T_Human1.35225480
43CBP_20019798_ChIP-Seq_JUKART_Human1.35020264
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35020264
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34411931
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33061201
47BCAT_22108803_ChIP-Seq_LS180_Human1.32756391
48AR_20517297_ChIP-Seq_VCAP_Human1.31957277
49EWS_26573619_Chip-Seq_HEK293_Human1.31121812
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31094154
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29522609
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.28636891
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28281408
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26561724
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23916136
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.23382972
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.22922014
58ELK1_19687146_ChIP-ChIP_HELA_Human1.22293394
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20979804
60EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20475452
61FOXH1_21741376_ChIP-Seq_EPCs_Human1.19759241
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.18971023
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.18460366
64RBPJ_21746931_ChIP-Seq_IB4_Human1.17756304
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17582998
66AR_21572438_ChIP-Seq_LNCaP_Human1.16840862
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16394936
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15897048
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15651543
70PHF8_20622853_ChIP-Seq_HELA_Human1.15449977
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15332904
72TCF4_22108803_ChIP-Seq_LS180_Human1.15251131
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13688321
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13545197
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12707300
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11593812
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11091872
78TCF4_23295773_ChIP-Seq_U87_Human1.10901163
79GATA6_21074721_ChIP-Seq_CACO-2_Human1.09219421
80MYC_19829295_ChIP-Seq_ESCs_Human1.09178966
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.08661264
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08104465
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.08104465
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07869107
85MYC_18940864_ChIP-ChIP_HL60_Human1.06493114
86CDX2_22108803_ChIP-Seq_LS180_Human1.04516309
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04328443
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04326096
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04113449
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.01337308
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01304358
92GBX2_23144817_ChIP-Seq_PC3_Human1.01247335
93P53_21459846_ChIP-Seq_SAOS-2_Human1.01026732
94AR_25329375_ChIP-Seq_VCAP_Human1.00823701
95CTCF_18555785_Chip-Seq_ESCs_Mouse1.00194780
96NFYA_21822215_ChIP-Seq_K562_Human0.99967828
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.99766485
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99612217
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99608452
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99241054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.81223274
2MP0000538_abnormal_urinary_bladder3.17691082
3MP0004043_abnormal_pH_regulation2.72690815
4MP0003122_maternal_imprinting2.41581148
5MP0003787_abnormal_imprinting2.41172302
6MP0005360_urolithiasis11.0307500
7MP0006276_abnormal_autonomic_nervous1.99632292
8MP0002876_abnormal_thyroid_physiology1.92628609
9MP0003195_calcinosis1.92321379
10MP0002163_abnormal_gland_morphology1.88811827
11MP0004742_abnormal_vestibular_system1.86814652
12MP0001984_abnormal_olfaction1.80232992
13MP0003121_genomic_imprinting1.73089289
14MP0001873_stomach_inflammation1.70876203
15MP0008877_abnormal_DNA_methylation1.69370288
16MP0001919_abnormal_reproductive_system1.69316573
17MP0001968_abnormal_touch/_nociception1.66337889
18MP0002733_abnormal_thermal_nociception1.65128612
19MP0008875_abnormal_xenobiotic_pharmacok1.62251230
20MP0002837_dystrophic_cardiac_calcinosis1.62049637
21MP0004142_abnormal_muscle_tone1.53664849
22MP0003315_abnormal_perineum_morphology1.53640081
23MP0002102_abnormal_ear_morphology1.53611514
24MP0005551_abnormal_eye_electrophysiolog1.51268745
25MP0005379_endocrine/exocrine_gland_phen1.49668871
26MP0001970_abnormal_pain_threshold1.42258783
27MP0001485_abnormal_pinna_reflex1.39553027
28MP0002909_abnormal_adrenal_gland1.36019301
29MP0003950_abnormal_plasma_membrane1.35454087
30MP0009046_muscle_twitch1.33535992
31MP0008961_abnormal_basal_metabolism1.33226334
32MP0008872_abnormal_physiological_respon1.32861094
33MP0009745_abnormal_behavioral_response1.31638989
34MP0001986_abnormal_taste_sensitivity1.29118968
35MP0005389_reproductive_system_phenotype1.28697823
36MP0006072_abnormal_retinal_apoptosis1.27832853
37MP0002254_reproductive_system_inflammat1.23901036
38MP0005187_abnormal_penis_morphology1.23252517
39MP0004145_abnormal_muscle_electrophysio1.21629358
40MP0002272_abnormal_nervous_system1.17855287
41MP0004133_heterotaxia1.16618149
42MP0001756_abnormal_urination1.16298553
43MP0004885_abnormal_endolymph1.15622634
44MP0005387_immune_system_phenotype1.13717327
45MP0001790_abnormal_immune_system1.13717327
46MP0002138_abnormal_hepatobiliary_system1.10402360
47MP0000613_abnormal_salivary_gland1.08081962
48MP0003252_abnormal_bile_duct1.05449832
49MP0005671_abnormal_response_to1.04845343
50MP0005332_abnormal_amino_acid1.04827074
51MP0002653_abnormal_ependyma_morphology1.04116080
52MP0005085_abnormal_gallbladder_physiolo1.03876029
53MP0001905_abnormal_dopamine_level1.03058837
54MP0010386_abnormal_urinary_bladder1.01979179
55MP0006292_abnormal_olfactory_placode0.91845431
56MP0005310_abnormal_salivary_gland0.90741792
57MP0003866_abnormal_defecation0.90229212
58MP0001440_abnormal_grooming_behavior0.89772792
59MP0005645_abnormal_hypothalamus_physiol0.88934010
60MP0001346_abnormal_lacrimal_gland0.87938844
61MP0002063_abnormal_learning/memory/cond0.86628443
62MP0009764_decreased_sensitivity_to0.86142128
63MP0003635_abnormal_synaptic_transmissio0.86030062
64MP0003879_abnormal_hair_cell0.85470895
65MP0000427_abnormal_hair_cycle0.83825962
66MP0006082_CNS_inflammation0.83291095
67MP0010329_abnormal_lipoprotein_level0.83070618
68MP0002734_abnormal_mechanical_nocicepti0.82711552
69MP0002210_abnormal_sex_determination0.82120071
70MP0009785_altered_susceptibility_to0.80611259
71MP0002735_abnormal_chemical_nociception0.80351211
72MP0002572_abnormal_emotion/affect_behav0.80277892
73MP0001486_abnormal_startle_reflex0.77925100
74MP0002160_abnormal_reproductive_system0.77682590
75MP0001663_abnormal_digestive_system0.74782425
76MP0002067_abnormal_sensory_capabilities0.73684822
77MP0005535_abnormal_body_temperature0.73509904
78MP0001944_abnormal_pancreas_morphology0.72110260
79MP0002557_abnormal_social/conspecific_i0.71357099
80MP0002234_abnormal_pharynx_morphology0.71135068
81MP0002064_seizures0.70825447
82MP0004085_abnormal_heartbeat0.70006569
83MP0003890_abnormal_embryonic-extraembry0.69579354
84MP0005365_abnormal_bile_salt0.68059939
85MP0008775_abnormal_heart_ventricle0.67558047
86MP0000685_abnormal_immune_system0.67005754
87MP0001800_abnormal_humoral_immune0.66483576
88MP0001929_abnormal_gametogenesis0.63036345
89MP0001765_abnormal_ion_homeostasis0.61651221
90MP0000631_abnormal_neuroendocrine_gland0.61557013
91MP0000372_irregular_coat_pigmentation0.61281374
92MP0003283_abnormal_digestive_organ0.61222708
93MP0005167_abnormal_blood-brain_barrier0.60563543
94MP0002736_abnormal_nociception_after0.60513371
95MP0003123_paternal_imprinting0.60498911
96MP0000230_abnormal_systemic_arterial0.60484526
97MP0005253_abnormal_eye_physiology0.60258629
98MP0002933_joint_inflammation0.59896808
99MP0003718_maternal_effect0.59298698
100MP0003724_increased_susceptibility_to0.56281041

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)5.02564270
2Hypomagnesemia (HP:0002917)4.72702432
3Generalized aminoaciduria (HP:0002909)4.46808475
4Abnormality of the renal cortex (HP:0011035)4.06779580
5Abnormality of magnesium homeostasis (HP:0004921)3.99069426
6Nephronophthisis (HP:0000090)3.71584453
7Fetal akinesia sequence (HP:0001989)3.61055907
8Type II lissencephaly (HP:0007260)3.44460068
9Tongue fasciculations (HP:0001308)3.33302738
10Abnormality of the labia minora (HP:0012880)3.30882968
11Pachygyria (HP:0001302)3.28508087
12Pancreatic cysts (HP:0001737)3.25399154
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.24359987
14Severe muscular hypotonia (HP:0006829)3.23681312
15Cerebellar dysplasia (HP:0007033)3.18770567
16Hepatic necrosis (HP:0002605)3.14653269
17Abnormality of the renal medulla (HP:0100957)3.11359461
18Proximal tubulopathy (HP:0000114)3.07444921
19Congenital stationary night blindness (HP:0007642)3.04469544
20Aplasia/hypoplasia of the uterus (HP:0008684)2.94502161
21Abnormality of midbrain morphology (HP:0002418)2.92853633
22Molar tooth sign on MRI (HP:0002419)2.92853633
23Hypoglycemic coma (HP:0001325)2.88538991
24Arthropathy (HP:0003040)2.87761896
25Pancreatic fibrosis (HP:0100732)2.82643338
26Abnormal rod and cone electroretinograms (HP:0008323)2.77853587
27Muscle fibrillation (HP:0010546)2.76555852
28True hermaphroditism (HP:0010459)2.67083757
29Type 2 muscle fiber atrophy (HP:0003554)2.58865983
30Recurrent cutaneous fungal infections (HP:0011370)2.58590037
31Chronic mucocutaneous candidiasis (HP:0002728)2.58590037
32IgG deficiency (HP:0004315)2.50721164
33Cheilitis (HP:0100825)2.49562049
34Progressive inability to walk (HP:0002505)2.47637278
353-Methylglutaconic aciduria (HP:0003535)2.46897778
36Acute necrotizing encephalopathy (HP:0006965)2.44302570
37Hypoplasia of the uterus (HP:0000013)2.43475956
38Reduced antithrombin III activity (HP:0001976)2.41876489
39Chronic hepatic failure (HP:0100626)2.41068285
40Poor suck (HP:0002033)2.37582695
41Abnormality of the ileum (HP:0001549)2.34696718
42Hypoplasia of the pons (HP:0012110)2.34350162
43Abnormality of the pons (HP:0007361)2.29715947
44Medial flaring of the eyebrow (HP:0010747)2.28605228
45Acute encephalopathy (HP:0006846)2.27907894
46Parakeratosis (HP:0001036)2.27487172
47Increased CSF lactate (HP:0002490)2.25415187
48Occipital encephalocele (HP:0002085)2.24269107
49Lissencephaly (HP:0001339)2.21185570
50Polyuria (HP:0000103)2.20238102
51Mutism (HP:0002300)2.16421568
52Progressive macrocephaly (HP:0004481)2.12059621
53Hepatocellular necrosis (HP:0001404)2.11907897
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11580079
55Abnormality of alanine metabolism (HP:0010916)2.11580079
56Hyperalaninemia (HP:0003348)2.11580079
57Renal tubular acidosis (HP:0001947)2.11139401
58Stomatitis (HP:0010280)2.06821444
59Meckel diverticulum (HP:0002245)2.06590570
60Aplastic anemia (HP:0001915)2.04333845
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03433310
62Muscle fiber atrophy (HP:0100295)2.02657194
63Volvulus (HP:0002580)2.01965725
64Fibular aplasia (HP:0002990)2.01679176
65Increased IgM level (HP:0003496)2.00658351
66Abnormality of lateral ventricle (HP:0030047)1.98125933
67Abnormal pancreas size (HP:0012094)1.98094948
68Abnormal mitochondria in muscle tissue (HP:0008316)1.94553759
69Polyphagia (HP:0002591)1.93556179
70Abolished electroretinogram (ERG) (HP:0000550)1.89473413
71Short hallux (HP:0010109)1.88738029
72Elevated erythrocyte sedimentation rate (HP:0003565)1.85573939
73Polydipsia (HP:0001959)1.85447811
74Abnormal drinking behavior (HP:0030082)1.85447811
75Mitochondrial inheritance (HP:0001427)1.85039797
76Increased serum pyruvate (HP:0003542)1.84637623
77Delayed puberty (HP:0000823)1.83488474
78Tetany (HP:0001281)1.83114976
79Tubular atrophy (HP:0000092)1.82778731
80Optic disc pallor (HP:0000543)1.82614372
81Abnormality of fatty-acid metabolism (HP:0004359)1.78838467
82Congenital hepatic fibrosis (HP:0002612)1.78758848
83Alkalosis (HP:0001948)1.76717766
84Bile duct proliferation (HP:0001408)1.76395780
85Abnormal biliary tract physiology (HP:0012439)1.76395780
86Anosmia (HP:0000458)1.75970560
87Epileptic encephalopathy (HP:0200134)1.75351578
88Abnormal urine output (HP:0012590)1.74618402
89Agitation (HP:0000713)1.74238572
90Delayed CNS myelination (HP:0002188)1.74070146
91Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73837014
92Hypoplasia of the brainstem (HP:0002365)1.73837014
93Spastic paraparesis (HP:0002313)1.72879255
94Abnormality of the proximal phalanges of the hand (HP:0009834)1.71423020
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.69719859
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69564099
97Short 1st metacarpal (HP:0010034)1.69564099
98Decreased central vision (HP:0007663)1.69312935
99Attenuation of retinal blood vessels (HP:0007843)1.69108964
100Sclerocornea (HP:0000647)1.68668015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.93718439
2BMPR1B3.78617739
3SIK23.64688522
4WNK43.58296751
5WNK33.52615987
6FLT33.10137186
7NUAK12.92420531
8CDK82.70349795
9NEK22.59075267
10TXK2.43225583
11NEK12.41839127
12TAOK32.23586681
13PNCK2.22485269
14PKN22.22396747
15LIMK12.20997671
16EIF2AK32.05106800
17TGFBR11.86524570
18ADRBK21.82282124
19GRK11.77680196
20BUB11.76778515
21ZAK1.61798287
22EIF2AK11.55945274
23PLK21.43641001
24MAP2K61.37446126
25PHKG11.34752293
26PHKG21.34752293
27TLK11.32120115
28MAP2K71.30365425
29MST41.29001125
30MINK11.25152433
31TNIK1.20987818
32TAF11.19856517
33TSSK61.14056210
34NTRK21.09487646
35STK391.05700140
36MAP4K21.04201065
37PRKD31.03967548
38MKNK21.03744304
39DMPK1.03100313
40PTK60.98593147
41AKT30.93193961
42STK38L0.92926999
43KIT0.92614311
44PLK40.91819876
45OXSR10.87357358
46PRKCI0.84065511
47TYK20.82477352
48PRKCG0.79914911
49TRIM280.77833925
50CASK0.76030711
51TIE10.74975010
52STK240.73334810
53DYRK20.70063907
54PAK30.68841765
55ACVR1B0.63969747
56CDK90.59966673
57NTRK10.59407510
58PRKCE0.55576466
59BCR0.55474456
60PINK10.54277868
61ERBB30.52375668
62ITK0.50806264
63PLK30.50192300
64TESK10.49287332
65PRKCQ0.49217651
66DYRK30.45066013
67STK110.44736065
68INSRR0.44122422
69ABL20.44004372
70SYK0.42859052
71MAP3K40.42597380
72IRAK10.41701910
73ADRBK10.41011656
74TEC0.39571766
75PTK20.39181881
76EIF2AK20.38378547
77STK30.37958692
78MAPK130.36672271
79NME10.36486238
80PRKG10.36436246
81LYN0.35621169
82PKN10.35560495
83SIK30.35034892
84SGK2230.33135007
85SGK4940.33135007
86IKBKB0.32264144
87PRKCA0.31609143
88CSNK1A10.30378657
89SGK20.27668689
90MARK10.27177972
91PAK10.26032156
92PRKCZ0.25698205
93CSNK1E0.25050888
94PRKACA0.23700135
95ATM0.22733270
96PRKCH0.22626259
97IKBKE0.22354979
98PLK10.22123766
99CAMKK20.22118957
100MAP4K10.21869395

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.77891000
2Butanoate metabolism_Homo sapiens_hsa006502.55264369
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.50845788
4Proteasome_Homo sapiens_hsa030502.45452441
5Oxidative phosphorylation_Homo sapiens_hsa001902.40280661
6Caffeine metabolism_Homo sapiens_hsa002322.39791039
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31396747
8Protein export_Homo sapiens_hsa030602.22793531
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15530661
10Taste transduction_Homo sapiens_hsa047422.15072745
11Basal transcription factors_Homo sapiens_hsa030222.06970850
12Olfactory transduction_Homo sapiens_hsa047401.96348896
13RNA degradation_Homo sapiens_hsa030181.90467832
14Parkinsons disease_Homo sapiens_hsa050121.86678750
15RNA polymerase_Homo sapiens_hsa030201.83756844
16Nitrogen metabolism_Homo sapiens_hsa009101.81984795
17Phototransduction_Homo sapiens_hsa047441.79209529
18Linoleic acid metabolism_Homo sapiens_hsa005911.68329765
19Tryptophan metabolism_Homo sapiens_hsa003801.68001421
20Sulfur metabolism_Homo sapiens_hsa009201.57468158
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55134094
22Primary immunodeficiency_Homo sapiens_hsa053401.54884515
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53847150
24Peroxisome_Homo sapiens_hsa041461.47162580
25Cardiac muscle contraction_Homo sapiens_hsa042601.46980659
26Morphine addiction_Homo sapiens_hsa050321.40848198
27Nicotine addiction_Homo sapiens_hsa050331.36273432
28Insulin secretion_Homo sapiens_hsa049111.34701430
29Vitamin B6 metabolism_Homo sapiens_hsa007501.34354578
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33950014
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30528445
32Huntingtons disease_Homo sapiens_hsa050161.30441666
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30060705
34Regulation of autophagy_Homo sapiens_hsa041401.28995784
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18461716
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15971854
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15113200
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14910276
39beta-Alanine metabolism_Homo sapiens_hsa004101.11886636
40Propanoate metabolism_Homo sapiens_hsa006401.11428713
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10599811
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.10363303
43Steroid biosynthesis_Homo sapiens_hsa001001.08332511
44Folate biosynthesis_Homo sapiens_hsa007901.05793452
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05615958
46Selenocompound metabolism_Homo sapiens_hsa004501.04712951
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04406588
48Ovarian steroidogenesis_Homo sapiens_hsa049131.04269975
49GABAergic synapse_Homo sapiens_hsa047271.03100181
50Alzheimers disease_Homo sapiens_hsa050100.97676398
51Mineral absorption_Homo sapiens_hsa049780.97594148
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.97305062
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96694684
54Ether lipid metabolism_Homo sapiens_hsa005650.92934868
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91207622
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88698151
57Type I diabetes mellitus_Homo sapiens_hsa049400.87655457
58Fatty acid metabolism_Homo sapiens_hsa012120.87277221
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82965425
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82689050
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81162004
62ABC transporters_Homo sapiens_hsa020100.79283103
63Salivary secretion_Homo sapiens_hsa049700.77573292
64Serotonergic synapse_Homo sapiens_hsa047260.77393444
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.75597249
66Synaptic vesicle cycle_Homo sapiens_hsa047210.74970650
67Collecting duct acid secretion_Homo sapiens_hsa049660.74453164
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74217843
69Dopaminergic synapse_Homo sapiens_hsa047280.72908418
70Circadian entrainment_Homo sapiens_hsa047130.72842927
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69525801
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63547373
73Bile secretion_Homo sapiens_hsa049760.62771451
74Pancreatic secretion_Homo sapiens_hsa049720.61093995
75Retinol metabolism_Homo sapiens_hsa008300.60284281
76Homologous recombination_Homo sapiens_hsa034400.60233798
77Fanconi anemia pathway_Homo sapiens_hsa034600.60068634
78Starch and sucrose metabolism_Homo sapiens_hsa005000.57540604
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56583795
80Fatty acid elongation_Homo sapiens_hsa000620.56574072
81Fatty acid degradation_Homo sapiens_hsa000710.53805573
82Metabolic pathways_Homo sapiens_hsa011000.53461090
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52487050
84Glutamatergic synapse_Homo sapiens_hsa047240.52030946
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50420033
86Chemical carcinogenesis_Homo sapiens_hsa052040.48517159
87Hematopoietic cell lineage_Homo sapiens_hsa046400.48453862
88Hedgehog signaling pathway_Homo sapiens_hsa043400.48097824
89Pyrimidine metabolism_Homo sapiens_hsa002400.47917391
90Fat digestion and absorption_Homo sapiens_hsa049750.46193828
91Arachidonic acid metabolism_Homo sapiens_hsa005900.45922862
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45655400
93Allograft rejection_Homo sapiens_hsa053300.45033541
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44362449
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.42511546
96Purine metabolism_Homo sapiens_hsa002300.42414384
97Sphingolipid metabolism_Homo sapiens_hsa006000.40664991
98TGF-beta signaling pathway_Homo sapiens_hsa043500.40272194
99Cocaine addiction_Homo sapiens_hsa050300.38802840
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38580107

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