PPIAP13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.62343667
2DNA deamination (GO:0045006)6.58803151
3cytidine deamination (GO:0009972)6.42674276
4cytidine metabolic process (GO:0046087)6.42674276
5cytidine catabolic process (GO:0006216)6.42674276
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.53099725
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.90296715
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.73060626
9ATP synthesis coupled proton transport (GO:0015986)4.39019319
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.39019319
11negative regulation by host of viral transcription (GO:0043922)4.30386088
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27476495
13sequestering of actin monomers (GO:0042989)4.20348991
14electron transport chain (GO:0022900)4.09745565
15respiratory electron transport chain (GO:0022904)4.06564007
16platelet dense granule organization (GO:0060155)3.70934658
17positive regulation of calcium-mediated signaling (GO:0050850)3.66140212
18protein complex biogenesis (GO:0070271)3.57979349
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57551191
20mannosylation (GO:0097502)3.52301994
21regulation of cellular amino acid metabolic process (GO:0006521)3.51236160
22proteasome assembly (GO:0043248)3.50142514
23regulation of chronic inflammatory response (GO:0002676)3.43624091
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37216928
25mast cell activation (GO:0045576)3.37089812
26chaperone-mediated protein transport (GO:0072321)3.26868237
27GPI anchor biosynthetic process (GO:0006506)3.25794781
28actin nucleation (GO:0045010)3.25735584
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25618033
30GPI anchor metabolic process (GO:0006505)3.22713966
31iron-sulfur cluster assembly (GO:0016226)3.20858159
32metallo-sulfur cluster assembly (GO:0031163)3.20858159
33cellular response to interleukin-15 (GO:0071350)3.19705136
34negative regulation of mast cell activation (GO:0033004)3.18549924
35mitochondrial respiratory chain complex assembly (GO:0033108)3.16489806
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15908839
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15908839
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15908839
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15121638
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14607888
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.14607888
42NADH dehydrogenase complex assembly (GO:0010257)3.14607888
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13313188
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13313188
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12050775
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04275231
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04275231
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04172787
49regulation of calcium-mediated signaling (GO:0050848)3.02750318
50eosinophil chemotaxis (GO:0048245)3.02726869
51negative regulation of ligase activity (GO:0051352)3.02708782
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02708782
53mast cell degranulation (GO:0043303)3.00617296
54mast cell activation involved in immune response (GO:0002279)3.00617296
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.00579015
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00579015
57negative regulation of T cell apoptotic process (GO:0070233)2.98998833
58signal transduction involved in cell cycle checkpoint (GO:0072395)2.95755039
59positive regulation of interleukin-8 secretion (GO:2000484)2.95377791
60cullin deneddylation (GO:0010388)2.94805259
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93080378
62kynurenine metabolic process (GO:0070189)2.92548728
63negative T cell selection (GO:0043383)2.92499059
64pyrimidine nucleoside catabolic process (GO:0046135)2.91966124
65regulation of interleukin-8 secretion (GO:2000482)2.90123412
66ribosomal small subunit assembly (GO:0000028)2.89142376
67hydrogen ion transmembrane transport (GO:1902600)2.86623755
68positive thymic T cell selection (GO:0045059)2.86493056
69regulation of T cell tolerance induction (GO:0002664)2.85031017
70regulation of activation of Janus kinase activity (GO:0010533)2.83175234
71proton transport (GO:0015992)2.81410535
72DNA demethylation (GO:0080111)2.80228389
73positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.77101449
74hydrogen transport (GO:0006818)2.74552465
75respiratory chain complex IV assembly (GO:0008535)2.74421995
76eosinophil migration (GO:0072677)2.73962312
77regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.71877858
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71589369
79T cell migration (GO:0072678)2.66424042
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65989358
81regulation of isotype switching to IgG isotypes (GO:0048302)2.65266430
82positive T cell selection (GO:0043368)2.60093980
83positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.59852058
84protein deneddylation (GO:0000338)2.59395464
85regulation of cellular amine metabolic process (GO:0033238)2.59386964
86preassembly of GPI anchor in ER membrane (GO:0016254)2.58963457
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55006154
88positive regulation of defense response to virus by host (GO:0002230)2.53629462
89negative thymic T cell selection (GO:0045060)2.52502697
90cytochrome complex assembly (GO:0017004)2.51523194
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50961917
92positive regulation of interleukin-1 beta secretion (GO:0050718)2.50896195
93positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.49933345
94positive regulation of natural killer cell mediated immunity (GO:0002717)2.47944224
95macrophage chemotaxis (GO:0048246)2.47656957
96piRNA metabolic process (GO:0034587)2.47508352
97antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46650475
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.46557768
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46548694
100negative regulation of stress fiber assembly (GO:0051497)2.45214649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.93324720
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.67592076
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45106568
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42716524
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.39623449
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34551288
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26047412
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13320489
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.96658293
10VDR_22108803_ChIP-Seq_LS180_Human2.93500237
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91614801
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78704504
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.64887912
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57739275
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56816164
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39157905
17ZNF274_21170338_ChIP-Seq_K562_Hela2.31850141
18VDR_23849224_ChIP-Seq_CD4+_Human2.30623251
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.16078886
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10990415
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.07373824
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06408894
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99165085
24ELK1_19687146_ChIP-ChIP_HELA_Human1.96634302
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94305016
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.93099467
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87355629
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.83369431
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.80917115
30FOXP3_21729870_ChIP-Seq_TREG_Human1.78222856
31MYB_26560356_Chip-Seq_TH2_Human1.75518078
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65629170
33GATA3_26560356_Chip-Seq_TH2_Human1.62469960
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.61271681
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59942983
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53612386
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48437170
38TP53_22573176_ChIP-Seq_HFKS_Human1.44383539
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42331137
40EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41528916
41RUNX_20019798_ChIP-Seq_JUKART_Human1.39971054
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38826712
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.36686063
44MYC_18940864_ChIP-ChIP_HL60_Human1.35628163
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34842294
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.33830223
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32309671
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29367552
49AR_20517297_ChIP-Seq_VCAP_Human1.26389628
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23594181
51TAF2_19829295_ChIP-Seq_ESCs_Human1.22717604
52GATA3_27048872_Chip-Seq_THYMUS_Human1.22610955
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21065686
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18734284
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18238909
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16193635
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15186686
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14483055
59NANOG_20526341_ChIP-Seq_ESCs_Human1.14108076
60ERG_20517297_ChIP-Seq_VCAP_Human1.13624387
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11982521
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.11675595
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11675595
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07323969
65IRF1_19129219_ChIP-ChIP_H3396_Human1.07298857
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05280737
67BCL6_27268052_Chip-Seq_Bcells_Human1.04788790
68NCOR_22424771_ChIP-Seq_293T_Human1.04595231
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04524788
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04114056
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03877011
72MYC_19829295_ChIP-Seq_ESCs_Human1.03541622
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03222828
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.02920614
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00990903
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00357137
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00116185
78P300_27268052_Chip-Seq_Bcells_Human1.00070969
79SOX2_19829295_ChIP-Seq_ESCs_Human0.97748500
80NANOG_19829295_ChIP-Seq_ESCs_Human0.97748500
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96470350
82ERA_21632823_ChIP-Seq_H3396_Human0.96228723
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96216749
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96105331
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95224590
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93943320
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.93938450
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93615465
89DCP1A_22483619_ChIP-Seq_HELA_Human0.92748780
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92117448
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92103302
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91582618
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.91554251
94E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90824861
95STAT1_20625510_ChIP-Seq_HELA_Human0.90475359
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90423277
97IGF1R_20145208_ChIP-Seq_DFB_Human0.90213167
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89721692
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87968279
100MYB_26560356_Chip-Seq_TH1_Human0.87729429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.23994277
2MP0005377_hearing/vestibular/ear_phenot3.42851856
3MP0003878_abnormal_ear_physiology3.42851856
4MP0001835_abnormal_antigen_presentation2.85877530
5MP0009785_altered_susceptibility_to2.48326452
6MP0009333_abnormal_splenocyte_physiolog2.39928145
7MP0003724_increased_susceptibility_to2.37495182
8MP0004147_increased_porphyrin_level2.34020328
9MP0006072_abnormal_retinal_apoptosis2.23488491
10MP0002148_abnormal_hypersensitivity_rea2.20261266
11MP0002166_altered_tumor_susceptibility2.16104796
12MP0005000_abnormal_immune_tolerance2.12647566
13MP0002102_abnormal_ear_morphology2.09458860
14MP0001800_abnormal_humoral_immune2.03956768
15MP0001485_abnormal_pinna_reflex1.98871544
16MP0008872_abnormal_physiological_respon1.98770685
17MP0006082_CNS_inflammation1.86025680
18MP0008875_abnormal_xenobiotic_pharmacok1.85368729
19MP0003763_abnormal_thymus_physiology1.83400045
20MP0005084_abnormal_gallbladder_morpholo1.76074421
21MP0001873_stomach_inflammation1.74651617
22MP0002723_abnormal_immune_serum1.73501973
23MP0002163_abnormal_gland_morphology1.70027759
24MP0005551_abnormal_eye_electrophysiolog1.69435090
25MP0002420_abnormal_adaptive_immunity1.65105386
26MP0005645_abnormal_hypothalamus_physiol1.64709679
27MP0002006_tumorigenesis1.63545991
28MP0001819_abnormal_immune_cell1.62360900
29MP0000372_irregular_coat_pigmentation1.61692325
30MP0006036_abnormal_mitochondrial_physio1.58245162
31MP0002837_dystrophic_cardiac_calcinosis1.52799993
32MP0009379_abnormal_foot_pigmentation1.47744885
33MP0001905_abnormal_dopamine_level1.47407593
34MP0002452_abnormal_antigen_presenting1.45872765
35MP0004145_abnormal_muscle_electrophysio1.42879739
36MP0005025_abnormal_response_to1.39562688
37MP0003786_premature_aging1.36560671
38MP0001968_abnormal_touch/_nociception1.35156637
39MP0003195_calcinosis1.34835702
40MP0003866_abnormal_defecation1.33961392
41MP0009764_decreased_sensitivity_to1.30843396
42MP0003252_abnormal_bile_duct1.29146012
43MP0001919_abnormal_reproductive_system1.27197825
44MP0003137_abnormal_impulse_conducting1.26772868
45MP0003646_muscle_fatigue1.22061606
46MP0002736_abnormal_nociception_after1.18674884
47MP0000716_abnormal_immune_system1.18289794
48MP0005387_immune_system_phenotype1.17119038
49MP0001790_abnormal_immune_system1.17119038
50MP0002876_abnormal_thyroid_physiology1.17101307
51MP0003136_yellow_coat_color1.16512721
52MP0005253_abnormal_eye_physiology1.15565794
53MP0000685_abnormal_immune_system1.15507979
54MP0003436_decreased_susceptibility_to1.13369886
55MP0002398_abnormal_bone_marrow1.13132310
56MP0008995_early_reproductive_senescence1.11474222
57MP0005379_endocrine/exocrine_gland_phen1.10948465
58MP0004885_abnormal_endolymph1.10633054
59MP0004142_abnormal_muscle_tone1.09753600
60MP0008877_abnormal_DNA_methylation1.08712856
61MP0003880_abnormal_central_pattern1.08506456
62MP0002933_joint_inflammation1.07961772
63MP0002277_abnormal_respiratory_mucosa1.07329833
64MP0002928_abnormal_bile_duct1.06629882
65MP0009745_abnormal_behavioral_response1.06436013
66MP0001845_abnormal_inflammatory_respons1.05647138
67MP0005389_reproductive_system_phenotype1.03137113
68MP0002138_abnormal_hepatobiliary_system1.02023411
69MP0003806_abnormal_nucleotide_metabolis1.00788984
70MP0002405_respiratory_system_inflammati1.00090555
71MP0000516_abnormal_urinary_system1.00077876
72MP0005367_renal/urinary_system_phenotyp1.00077876
73MP0001486_abnormal_startle_reflex0.98874881
74MP0001765_abnormal_ion_homeostasis0.98593722
75MP0010155_abnormal_intestine_physiology0.98125486
76MP0001501_abnormal_sleep_pattern0.97165353
77MP0002638_abnormal_pupillary_reflex0.96358805
78MP0002419_abnormal_innate_immunity0.95066444
79MP0005075_abnormal_melanosome_morpholog0.93609531
80MP0003011_delayed_dark_adaptation0.92703604
81MP0001970_abnormal_pain_threshold0.92353051
82MP0000689_abnormal_spleen_morphology0.91625879
83MP0002429_abnormal_blood_cell0.90475373
84MP0005167_abnormal_blood-brain_barrier0.89799332
85MP0002272_abnormal_nervous_system0.89179138
86MP0002653_abnormal_ependyma_morphology0.89054051
87MP0005636_abnormal_mineral_homeostasis0.86646756
88MP0005085_abnormal_gallbladder_physiolo0.83925459
89MP0008469_abnormal_protein_level0.83749238
90MP0002095_abnormal_skin_pigmentation0.82152181
91MP0002160_abnormal_reproductive_system0.81654884
92MP0002722_abnormal_immune_system0.81013199
93MP0001879_abnormal_lymphatic_vessel0.78629314
94MP0002009_preneoplasia0.77511067
95MP0001963_abnormal_hearing_physiology0.77097784
96MP0000026_abnormal_inner_ear0.75841820
97MP0001986_abnormal_taste_sensitivity0.74843363
98MP0006035_abnormal_mitochondrial_morpho0.74551868
99MP0001533_abnormal_skeleton_physiology0.73609310
100MP0005360_urolithiasis0.73526606

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.49779660
2Abnormal mitochondria in muscle tissue (HP:0008316)4.42693568
3Mitochondrial inheritance (HP:0001427)4.33535094
43-Methylglutaconic aciduria (HP:0003535)4.26105464
5Hepatocellular necrosis (HP:0001404)3.94577974
6IgG deficiency (HP:0004315)3.84094658
7Abnormality of T cell number (HP:0011839)3.81069094
8Progressive macrocephaly (HP:0004481)3.71939757
9Increased CSF lactate (HP:0002490)3.70721098
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.68280728
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.68280728
12T lymphocytopenia (HP:0005403)3.62920139
13Acute encephalopathy (HP:0006846)3.59245990
14Hepatic necrosis (HP:0002605)3.49835091
15Aplastic anemia (HP:0001915)3.43162411
16Severe combined immunodeficiency (HP:0004430)3.39227852
17Increased IgM level (HP:0003496)3.26554544
18Congenital, generalized hypertrichosis (HP:0004540)3.26114652
19Congenital stationary night blindness (HP:0007642)3.18339173
20Hypoproteinemia (HP:0003075)3.00406914
21Pancreatic cysts (HP:0001737)2.99285053
22Abnormality of T cells (HP:0002843)2.93453376
23Cerebral edema (HP:0002181)2.92964986
24Abolished electroretinogram (ERG) (HP:0000550)2.86742706
25Pancreatic fibrosis (HP:0100732)2.78554419
26Increased intramyocellular lipid droplets (HP:0012240)2.78522808
27Abnormality of eosinophils (HP:0001879)2.77657038
28True hermaphroditism (HP:0010459)2.76020212
29Stomatitis (HP:0010280)2.73292902
30Increased serum lactate (HP:0002151)2.63573409
31Optic disc pallor (HP:0000543)2.62659402
32Stomach cancer (HP:0012126)2.59549333
33Abnormal rod and cone electroretinograms (HP:0008323)2.57133532
34Autoimmune hemolytic anemia (HP:0001890)2.55775760
35Combined immunodeficiency (HP:0005387)2.54149915
36Thyroiditis (HP:0100646)2.49882843
37Lactic acidosis (HP:0003128)2.48629927
38Elevated erythrocyte sedimentation rate (HP:0003565)2.41722086
39Attenuation of retinal blood vessels (HP:0007843)2.41155698
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.36284964
41Increased muscle lipid content (HP:0009058)2.34515328
42Short tibia (HP:0005736)2.32325606
43Eosinophilia (HP:0001880)2.30518976
44Abnormality of B cell number (HP:0010975)2.28080801
45Respiratory failure (HP:0002878)2.27010504
46Abnormality of the prostate (HP:0008775)2.25686575
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22904085
48Renal cortical cysts (HP:0000803)2.22778746
49Autoimmune thrombocytopenia (HP:0001973)2.22347181
50Lethargy (HP:0001254)2.18560023
51Exercise intolerance (HP:0003546)2.15342279
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.14670565
53Lipid accumulation in hepatocytes (HP:0006561)2.09966877
54Abnormality of binocular vision (HP:0011514)2.09959104
55Diplopia (HP:0000651)2.09959104
56Increased hepatocellular lipid droplets (HP:0006565)2.09877501
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.06998161
58Abnormality of T cell physiology (HP:0011840)2.06229924
59Molar tooth sign on MRI (HP:0002419)2.05984507
60Abnormality of midbrain morphology (HP:0002418)2.05984507
61Abnormality of the renal cortex (HP:0011035)2.05506528
62Leukodystrophy (HP:0002415)2.04979942
63Oral leukoplakia (HP:0002745)2.04453939
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02741844
65Sclerocornea (HP:0000647)2.01685394
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00475293
67Supernumerary spleens (HP:0009799)1.99662201
68Medial flaring of the eyebrow (HP:0010747)1.93165702
69Pancytopenia (HP:0001876)1.90822824
70Generalized aminoaciduria (HP:0002909)1.90122844
71Abnormal biliary tract physiology (HP:0012439)1.89714453
72Bile duct proliferation (HP:0001408)1.89714453
73Confusion (HP:0001289)1.89380959
74Chronic diarrhea (HP:0002028)1.86921184
75Decreased central vision (HP:0007663)1.86228761
76Type I transferrin isoform profile (HP:0003642)1.85808175
77CNS demyelination (HP:0007305)1.85002731
78Renal Fanconi syndrome (HP:0001994)1.84002274
79Microretrognathia (HP:0000308)1.81920180
80Methylmalonic aciduria (HP:0012120)1.80445014
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79105808
82Cerebral palsy (HP:0100021)1.78835846
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76818615
84Dicarboxylic aciduria (HP:0003215)1.76818615
85Congenital primary aphakia (HP:0007707)1.75046583
86Chronic sinusitis (HP:0011109)1.74745797
87Anencephaly (HP:0002323)1.73748312
88Alkalosis (HP:0001948)1.73249678
89Granulocytopenia (HP:0001913)1.73196821
90Nephronophthisis (HP:0000090)1.72442683
91Gait imbalance (HP:0002141)1.72298267
92Abnormal respiratory epithelium morphology (HP:0012253)1.72044823
93Abnormal respiratory motile cilium morphology (HP:0005938)1.72044823
94Progressive microcephaly (HP:0000253)1.71863096
95Abnormal number of erythroid precursors (HP:0012131)1.70397265
96Methylmalonic acidemia (HP:0002912)1.70274371
97Hemiparesis (HP:0001269)1.68029876
98Postaxial foot polydactyly (HP:0001830)1.66415003
99Delayed CNS myelination (HP:0002188)1.65692874
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.65458254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.58380817
2MAP3K123.92906894
3KDR3.67617744
4TESK23.41638971
5ADRBK22.78613437
6VRK22.72618655
7ZAK2.44313957
8TLK12.15390970
9BUB12.15082771
10MAPK152.11279436
11CDK192.06366823
12GRK12.01354875
13VRK11.97992672
14LIMK11.93122222
15STK161.86276445
16TAOK31.85021013
17BMPR21.80938956
18MAP4K21.75163538
19TSSK61.70775835
20MYLK1.68422900
21CAMKK21.66564521
22PINK11.62581818
23MAP4K11.58164276
24TESK11.54426701
25NUAK11.53930599
26MAPKAPK31.51425840
27ITK1.50449247
28MST41.41518827
29BCKDK1.36327599
30GRK71.35370999
31OXSR11.34835430
32SCYL21.33777121
33CDK81.25791417
34WNK41.21886941
35NME11.21703415
36GRK61.21516136
37PIK3CG1.20917203
38PLK41.20242726
39DAPK11.16980528
40TAOK21.16833008
41TIE11.13100635
42STK391.00253599
43WEE10.95191813
44CSF1R0.94623413
45FES0.94333914
46PIK3CA0.89497336
47RPS6KA50.87263233
48TEC0.83190659
49ILK0.82250269
50INSRR0.79726660
51NEK10.79639019
52EPHB20.78675719
53MAP2K20.78517381
54MATK0.77517530
55BRSK20.76975080
56PRKCQ0.75036056
57PNCK0.74834608
58SYK0.73682174
59IKBKB0.69245883
60FRK0.68923455
61ERBB30.67995330
62LCK0.67512894
63MUSK0.66054792
64ADRBK10.64206354
65BMPR1B0.62723743
66ZAP700.61581658
67PASK0.61243243
68LYN0.59365444
69IRAK40.54302569
70BTK0.54268623
71PIM10.54261835
72PHKG10.54027216
73PHKG20.54027216
74MAP2K60.53172264
75MAPK130.52916155
76IGF1R0.52152996
77CAMKK10.50458624
78OBSCN0.49740206
79DAPK30.49456257
80ABL20.47779979
81CDK30.46533205
82RIPK40.45716434
83DYRK20.43499424
84GRK50.42876345
85KIT0.40936461
86LRRK20.38994347
87TRIM280.38945421
88MAP3K50.37219049
89ABL10.36213835
90TRPM70.35635685
91IKBKE0.34778824
92PLK30.34330428
93ROCK10.33729886
94TBK10.30664800
95MAPKAPK50.30477917
96MAP3K110.29394630
97PRKCA0.27323941
98CSNK2A10.26707137
99PRKCE0.25946945
100BRSK10.25594981

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.52777880
2Oxidative phosphorylation_Homo sapiens_hsa001903.79761167
3Primary immunodeficiency_Homo sapiens_hsa053403.41479193
4Parkinsons disease_Homo sapiens_hsa050123.19612901
5Allograft rejection_Homo sapiens_hsa053303.03990449
6Autoimmune thyroid disease_Homo sapiens_hsa053202.95837106
7Graft-versus-host disease_Homo sapiens_hsa053322.93023343
8Asthma_Homo sapiens_hsa053102.73944185
9Ribosome_Homo sapiens_hsa030102.40948544
10Antigen processing and presentation_Homo sapiens_hsa046122.33792428
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.31048642
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27876545
13Type I diabetes mellitus_Homo sapiens_hsa049402.26378853
14Protein export_Homo sapiens_hsa030602.23328097
15Alzheimers disease_Homo sapiens_hsa050102.11398478
16Rheumatoid arthritis_Homo sapiens_hsa053231.97514470
17RNA polymerase_Homo sapiens_hsa030201.95172592
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93645183
19Huntingtons disease_Homo sapiens_hsa050161.86001497
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77747179
21Cardiac muscle contraction_Homo sapiens_hsa042601.69233880
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55884815
23Hematopoietic cell lineage_Homo sapiens_hsa046401.55381977
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49884364
25Homologous recombination_Homo sapiens_hsa034401.44833122
26Nitrogen metabolism_Homo sapiens_hsa009101.22031384
27T cell receptor signaling pathway_Homo sapiens_hsa046601.21476956
28Phototransduction_Homo sapiens_hsa047441.20666735
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17185227
30Viral myocarditis_Homo sapiens_hsa054161.14724947
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11524926
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11410527
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10378514
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07642612
35One carbon pool by folate_Homo sapiens_hsa006701.02228653
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93014535
37Pyrimidine metabolism_Homo sapiens_hsa002400.92176069
38Butanoate metabolism_Homo sapiens_hsa006500.90819915
39Collecting duct acid secretion_Homo sapiens_hsa049660.87183992
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.86707361
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86510285
42Peroxisome_Homo sapiens_hsa041460.84894419
43Caffeine metabolism_Homo sapiens_hsa002320.84338955
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82269795
45RNA degradation_Homo sapiens_hsa030180.80567284
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80119996
47Sulfur metabolism_Homo sapiens_hsa009200.79893308
48DNA replication_Homo sapiens_hsa030300.79760481
49Systemic lupus erythematosus_Homo sapiens_hsa053220.79617686
50Mismatch repair_Homo sapiens_hsa034300.75563876
51Linoleic acid metabolism_Homo sapiens_hsa005910.72836069
52Leishmaniasis_Homo sapiens_hsa051400.72612304
53Chemical carcinogenesis_Homo sapiens_hsa052040.70474925
54Tryptophan metabolism_Homo sapiens_hsa003800.70413246
55Purine metabolism_Homo sapiens_hsa002300.67922465
56Measles_Homo sapiens_hsa051620.67571650
57Nucleotide excision repair_Homo sapiens_hsa034200.64161697
58Spliceosome_Homo sapiens_hsa030400.63005170
59Fanconi anemia pathway_Homo sapiens_hsa034600.62718924
60Fatty acid elongation_Homo sapiens_hsa000620.60752698
61Salmonella infection_Homo sapiens_hsa051320.57006757
62Propanoate metabolism_Homo sapiens_hsa006400.56164680
63Staphylococcus aureus infection_Homo sapiens_hsa051500.55296383
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55281489
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.53244400
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.51147503
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50141512
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50080429
69Basal transcription factors_Homo sapiens_hsa030220.49336426
70Retinol metabolism_Homo sapiens_hsa008300.49226704
71Metabolic pathways_Homo sapiens_hsa011000.48653948
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47843914
73Olfactory transduction_Homo sapiens_hsa047400.44158243
74Herpes simplex infection_Homo sapiens_hsa051680.44029621
75Arachidonic acid metabolism_Homo sapiens_hsa005900.43988605
76Glutathione metabolism_Homo sapiens_hsa004800.41266570
77Regulation of autophagy_Homo sapiens_hsa041400.40614956
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.39231443
79Nicotine addiction_Homo sapiens_hsa050330.38428972
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36547272
81Shigellosis_Homo sapiens_hsa051310.35309719
82Salivary secretion_Homo sapiens_hsa049700.33235242
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32352998
84Fat digestion and absorption_Homo sapiens_hsa049750.31289714
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30432491
86Epstein-Barr virus infection_Homo sapiens_hsa051690.30003527
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29997582
88Morphine addiction_Homo sapiens_hsa050320.29463458
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28898110
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27278713
91Fatty acid metabolism_Homo sapiens_hsa012120.26821937
92Legionellosis_Homo sapiens_hsa051340.26744262
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26445331
94Base excision repair_Homo sapiens_hsa034100.25783801
95Taste transduction_Homo sapiens_hsa047420.25732744
96Pyruvate metabolism_Homo sapiens_hsa006200.25505122
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.24093647
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23282859
99RNA transport_Homo sapiens_hsa030130.22939395
100African trypanosomiasis_Homo sapiens_hsa051430.22855900

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