PPIAP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.93144713
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.89290999
3DNA deamination (GO:0045006)4.77568545
4ATP synthesis coupled proton transport (GO:0015986)4.30139517
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30139517
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.25031690
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.25031690
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22844423
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.20289871
10chromatin remodeling at centromere (GO:0031055)4.12917817
11CENP-A containing nucleosome assembly (GO:0034080)4.12027313
12pyrimidine nucleotide catabolic process (GO:0006244)4.06303837
13DNA replication checkpoint (GO:0000076)3.95850515
14piRNA metabolic process (GO:0034587)3.95489785
15regulation of meiosis I (GO:0060631)3.91594018
16cullin deneddylation (GO:0010388)3.90906865
17protein deneddylation (GO:0000338)3.90664169
18chaperone-mediated protein transport (GO:0072321)3.89652046
19base-excision repair, AP site formation (GO:0006285)3.87170898
20multicellular organism reproduction (GO:0032504)3.85630057
21regulation of acrosome reaction (GO:0060046)3.78871375
22regulation of DNA methylation (GO:0044030)3.68655303
23meiotic cell cycle (GO:0051321)3.61318980
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60000812
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59045574
26retinal cone cell development (GO:0046549)3.58335684
27replication fork processing (GO:0031297)3.54156216
28respiratory electron transport chain (GO:0022904)3.50349550
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.47023082
30NADH dehydrogenase complex assembly (GO:0010257)3.47023082
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47023082
32electron transport chain (GO:0022900)3.46528640
33protein neddylation (GO:0045116)3.45112378
34maturation of SSU-rRNA (GO:0030490)3.43698345
35behavioral response to nicotine (GO:0035095)3.43311698
36protein complex biogenesis (GO:0070271)3.39367809
37water-soluble vitamin biosynthetic process (GO:0042364)3.37544498
38histone exchange (GO:0043486)3.36193582
39negative regulation of telomere maintenance (GO:0032205)3.35147928
40mitochondrial respiratory chain complex assembly (GO:0033108)3.33024874
41viral transcription (GO:0019083)3.30310801
42pseudouridine synthesis (GO:0001522)3.29963638
43translational termination (GO:0006415)3.29689462
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26575394
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.25820079
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.22046007
47termination of RNA polymerase III transcription (GO:0006386)3.22046007
48epithelial cilium movement (GO:0003351)3.20950015
49ribosomal small subunit biogenesis (GO:0042274)3.20840899
50proteasome assembly (GO:0043248)3.20215798
51ribosomal large subunit biogenesis (GO:0042273)3.18706859
52male meiosis I (GO:0007141)3.14547699
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11652524
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10817958
55cotranslational protein targeting to membrane (GO:0006613)3.04771338
56peptidyl-histidine modification (GO:0018202)3.04498477
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03964900
58protein peptidyl-prolyl isomerization (GO:0000413)3.03563445
59protein targeting to ER (GO:0045047)3.01613326
60translational elongation (GO:0006414)3.01305249
61cytidine metabolic process (GO:0046087)2.94501794
62cytidine catabolic process (GO:0006216)2.94501794
63cytidine deamination (GO:0009972)2.94501794
64deoxyribonucleotide catabolic process (GO:0009264)2.94265330
65DNA replication-independent nucleosome organization (GO:0034724)2.91974235
66DNA replication-independent nucleosome assembly (GO:0006336)2.91974235
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.90319320
68regulation of retinoic acid receptor signaling pathway (GO:0048385)2.90000282
69oocyte development (GO:0048599)2.89291563
70respiratory chain complex IV assembly (GO:0008535)2.88947373
71cellular component biogenesis (GO:0044085)2.86793946
72ribonucleoprotein complex biogenesis (GO:0022613)2.86065567
73protein localization to endoplasmic reticulum (GO:0070972)2.85121209
74protein polyglutamylation (GO:0018095)2.84816964
75establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84706812
76maturation of 5.8S rRNA (GO:0000460)2.81669321
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81355019
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.81352975
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79919620
80regulation of female gonad development (GO:2000194)2.79107129
81rRNA processing (GO:0006364)2.77851609
82translation (GO:0006412)2.77366237
83folic acid-containing compound biosynthetic process (GO:0009396)2.77271488
84ncRNA 3-end processing (GO:0043628)2.77005053
85DNA methylation involved in gamete generation (GO:0043046)2.76889780
86hydrogen ion transmembrane transport (GO:1902600)2.76583040
87regulation of oxidative phosphorylation (GO:0002082)2.76073434
88negative regulation of execution phase of apoptosis (GO:1900118)2.75434793
89regulation of mitochondrial translation (GO:0070129)2.75320561
90DNA catabolic process, exonucleolytic (GO:0000738)2.74251531
91translational initiation (GO:0006413)2.73953228
92positive regulation of histone H3-K4 methylation (GO:0051571)2.73106619
93deoxyribose phosphate catabolic process (GO:0046386)2.72252276
94rRNA metabolic process (GO:0016072)2.71431811
95meiosis I (GO:0007127)2.71223462
96negative regulation of DNA-dependent DNA replication (GO:2000104)2.70562641
97centriole replication (GO:0007099)2.67918671
98GTP biosynthetic process (GO:0006183)2.67377617
99ribosome biogenesis (GO:0042254)2.66663990
100cilium movement (GO:0003341)2.65769414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41769259
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07531523
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.02439316
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.25967655
5VDR_22108803_ChIP-Seq_LS180_Human3.06069923
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93256915
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82503754
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49445648
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.48628083
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43813411
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35709717
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35100152
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25873192
14ZNF274_21170338_ChIP-Seq_K562_Hela2.22551021
15IGF1R_20145208_ChIP-Seq_DFB_Human2.14292350
16E2F7_22180533_ChIP-Seq_HELA_Human2.11871938
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10261021
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08515198
19VDR_23849224_ChIP-Seq_CD4+_Human2.08009465
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06268285
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.06078276
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.04178546
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91631865
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.83486422
25ELK1_19687146_ChIP-ChIP_HELA_Human1.82284048
26MYC_18940864_ChIP-ChIP_HL60_Human1.76909996
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75902667
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73213135
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71037364
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70210975
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68669108
32TP53_22573176_ChIP-Seq_HFKS_Human1.63152118
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60482417
34FOXP3_21729870_ChIP-Seq_TREG_Human1.59695990
35IRF1_19129219_ChIP-ChIP_H3396_Human1.56577457
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56233620
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56144663
38GBX2_23144817_ChIP-Seq_PC3_Human1.51359307
39GABP_19822575_ChIP-Seq_HepG2_Human1.49756794
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45727844
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44274761
42EWS_26573619_Chip-Seq_HEK293_Human1.43568634
43TTF2_22483619_ChIP-Seq_HELA_Human1.42351264
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40792222
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.33216070
46FUS_26573619_Chip-Seq_HEK293_Human1.32000556
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30692735
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30149060
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27741653
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26316369
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25564887
52P300_19829295_ChIP-Seq_ESCs_Human1.24296442
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22618738
54AR_20517297_ChIP-Seq_VCAP_Human1.21714685
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20944336
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.20001595
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17688662
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17001299
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16125277
60DCP1A_22483619_ChIP-Seq_HELA_Human1.15858008
61SOX2_19829295_ChIP-Seq_ESCs_Human1.15842302
62NANOG_19829295_ChIP-Seq_ESCs_Human1.15842302
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14215185
64FOXH1_21741376_ChIP-Seq_EPCs_Human1.14128735
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13165551
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.13089850
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11405937
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10761991
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09272655
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09252444
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07561767
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07049087
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.06420099
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06420099
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06160981
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06142318
77NCOR_22424771_ChIP-Seq_293T_Human1.06030588
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01491766
79BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99711609
80HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99641625
81CBP_20019798_ChIP-Seq_JUKART_Human0.97171765
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97171765
83HTT_18923047_ChIP-ChIP_STHdh_Human0.96645096
84NANOG_20526341_ChIP-Seq_ESCs_Human0.96506481
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.95706598
86BCAT_22108803_ChIP-Seq_LS180_Human0.93349726
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92830355
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92431325
89REST_21632747_ChIP-Seq_MESCs_Mouse0.91763123
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.89887757
91ERA_21632823_ChIP-Seq_H3396_Human0.88478589
92NFE2_27457419_Chip-Seq_LIVER_Mouse0.87910799
93GATA3_21878914_ChIP-Seq_MCF-7_Human0.87793124
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87529400
95TCF4_22108803_ChIP-Seq_LS180_Human0.86891722
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86520403
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86482469
98HOXB7_26014856_ChIP-Seq_BT474_Human0.86448605
99TAF2_19829295_ChIP-Seq_ESCs_Human0.85858189
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85500117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.89868356
2MP0006292_abnormal_olfactory_placode3.85574458
3MP0003718_maternal_effect3.35460564
4MP0008877_abnormal_DNA_methylation3.11516698
5MP0003890_abnormal_embryonic-extraembry3.08059424
6MP0002102_abnormal_ear_morphology2.95742032
7MP0003693_abnormal_embryo_hatching2.92700392
8MP0008058_abnormal_DNA_repair2.64669713
9MP0000372_irregular_coat_pigmentation2.43068863
10MP0006276_abnormal_autonomic_nervous2.22446829
11MP0008789_abnormal_olfactory_epithelium2.20928959
12MP0006054_spinal_hemorrhage2.09738308
13MP0001986_abnormal_taste_sensitivity2.01380393
14MP0005394_taste/olfaction_phenotype1.92804506
15MP0005499_abnormal_olfactory_system1.92804506
16MP0001293_anophthalmia1.85162288
17MP0006072_abnormal_retinal_apoptosis1.84870054
18MP0004142_abnormal_muscle_tone1.74695800
19MP0002138_abnormal_hepatobiliary_system1.73095496
20MP0002272_abnormal_nervous_system1.71218740
21MP0005551_abnormal_eye_electrophysiolog1.62963897
22MP0010094_abnormal_chromosome_stability1.62712144
23MP0002160_abnormal_reproductive_system1.62564384
24MP0005084_abnormal_gallbladder_morpholo1.56759782
25MP0005646_abnormal_pituitary_gland1.56022488
26MP0005645_abnormal_hypothalamus_physiol1.55323933
27MP0004145_abnormal_muscle_electrophysio1.54159243
28MP0003121_genomic_imprinting1.47904762
29MP0002210_abnormal_sex_determination1.43202037
30MP0002876_abnormal_thyroid_physiology1.42937351
31MP0003283_abnormal_digestive_organ1.42312634
32MP0008875_abnormal_xenobiotic_pharmacok1.39471544
33MP0005389_reproductive_system_phenotype1.39075001
34MP0001929_abnormal_gametogenesis1.38987285
35MP0004957_abnormal_blastocyst_morpholog1.34520220
36MP0003950_abnormal_plasma_membrane1.34007468
37MP0004147_increased_porphyrin_level1.32131358
38MP0008932_abnormal_embryonic_tissue1.32113839
39MP0001984_abnormal_olfaction1.29987413
40MP0001529_abnormal_vocalization1.29059116
41MP0003786_premature_aging1.27155615
42MP0003186_abnormal_redox_activity1.25571578
43MP0000631_abnormal_neuroendocrine_gland1.23547114
44MP0005410_abnormal_fertilization1.23180157
45MP0006036_abnormal_mitochondrial_physio1.22983525
46MP0003077_abnormal_cell_cycle1.22520131
47MP0003806_abnormal_nucleotide_metabolis1.22367443
48MP0002163_abnormal_gland_morphology1.21611973
49MP0005174_abnormal_tail_pigmentation1.19137683
50MP0008872_abnormal_physiological_respon1.18086068
51MP0003787_abnormal_imprinting1.16233315
52MP0005075_abnormal_melanosome_morpholog1.13707092
53MP0000427_abnormal_hair_cycle1.12405661
54MP0002638_abnormal_pupillary_reflex1.08601732
55MP0002277_abnormal_respiratory_mucosa1.08022738
56MP0009745_abnormal_behavioral_response1.07177138
57MP0000653_abnormal_sex_gland1.07136125
58MP0001485_abnormal_pinna_reflex1.05820010
59MP0000049_abnormal_middle_ear1.05432735
60MP0002095_abnormal_skin_pigmentation1.03498775
61MP0005360_urolithiasis1.03117227
62MP0002938_white_spotting1.02900892
63MP0002733_abnormal_thermal_nociception1.02415574
64MP0001968_abnormal_touch/_nociception1.00561979
65MP0005085_abnormal_gallbladder_physiolo1.00277868
66MP0003699_abnormal_female_reproductive0.98215183
67MP0001905_abnormal_dopamine_level0.97091423
68MP0001119_abnormal_female_reproductive0.95763770
69MP0004133_heterotaxia0.94998580
70MP0006035_abnormal_mitochondrial_morpho0.94468503
71MP0002734_abnormal_mechanical_nocicepti0.94356693
72MP0003119_abnormal_digestive_system0.92977708
73MP0003936_abnormal_reproductive_system0.92674867
74MP0000015_abnormal_ear_pigmentation0.92055568
75MP0003880_abnormal_central_pattern0.91670123
76MP0001145_abnormal_male_reproductive0.89776874
77MP0002735_abnormal_chemical_nociception0.88184961
78MP0003698_abnormal_male_reproductive0.87151349
79MP0005423_abnormal_somatic_nervous0.86788665
80MP0003252_abnormal_bile_duct0.85526699
81MP0002161_abnormal_fertility/fecundity0.85211957
82MP0004270_analgesia0.84289592
83MP0003879_abnormal_hair_cell0.83714841
84MP0000778_abnormal_nervous_system0.82329889
85MP0005395_other_phenotype0.80962836
86MP0002557_abnormal_social/conspecific_i0.80853449
87MP0005195_abnormal_posterior_eye0.79220776
88MP0003635_abnormal_synaptic_transmissio0.79218353
89MP0002139_abnormal_hepatobiliary_system0.77700334
90MP0002837_dystrophic_cardiac_calcinosis0.77352320
91MP0003938_abnormal_ear_development0.77133584
92MP0002736_abnormal_nociception_after0.76446401
93MP0002090_abnormal_vision0.76192274
94MP0002572_abnormal_emotion/affect_behav0.75414154
95MP0002751_abnormal_autonomic_nervous0.74881945
96MP0001970_abnormal_pain_threshold0.74181412
97MP0003011_delayed_dark_adaptation0.73906409
98MP0002063_abnormal_learning/memory/cond0.73501274
99MP0009046_muscle_twitch0.73359540
100MP0010386_abnormal_urinary_bladder0.73235037

Predicted human phenotypes

RankGene SetZ-score
1Supernumerary spleens (HP:0009799)4.75050163
2Acute necrotizing encephalopathy (HP:0006965)4.58968725
3Abnormal mitochondria in muscle tissue (HP:0008316)3.91332780
4Acute encephalopathy (HP:0006846)3.88113029
5Progressive macrocephaly (HP:0004481)3.66563378
6Reticulocytopenia (HP:0001896)3.47082034
7Mitochondrial inheritance (HP:0001427)3.45884949
8Increased CSF lactate (HP:0002490)3.31551851
9Aplastic anemia (HP:0001915)3.30649508
10Abnormality of the labia minora (HP:0012880)3.18006181
11Abdominal situs inversus (HP:0003363)3.01988566
12Abnormality of abdominal situs (HP:0011620)3.01988566
13Molar tooth sign on MRI (HP:0002419)3.01772506
14Abnormality of midbrain morphology (HP:0002418)3.01772506
15Cerebral edema (HP:0002181)2.71919181
16Abnormal respiratory epithelium morphology (HP:0012253)2.64980784
17Abnormal respiratory motile cilium morphology (HP:0005938)2.64980784
18Absent thumb (HP:0009777)2.64490554
19Increased hepatocellular lipid droplets (HP:0006565)2.62464549
20Pancreatic fibrosis (HP:0100732)2.62160475
21Stenosis of the external auditory canal (HP:0000402)2.61267902
22Renal Fanconi syndrome (HP:0001994)2.59261380
23Pancreatic cysts (HP:0001737)2.57527343
24Abnormal ciliary motility (HP:0012262)2.51492084
25Lipid accumulation in hepatocytes (HP:0006561)2.50900459
26Increased serum lactate (HP:0002151)2.50142161
27Chromsome breakage (HP:0040012)2.48496033
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46607461
29Medial flaring of the eyebrow (HP:0010747)2.43611583
30Abnormality of cells of the erythroid lineage (HP:0012130)2.41273439
31Hepatic necrosis (HP:0002605)2.38557328
32Premature ovarian failure (HP:0008209)2.36855548
33Optic disc pallor (HP:0000543)2.36740961
34Myokymia (HP:0002411)2.36341939
35Hepatocellular necrosis (HP:0001404)2.36281614
36Short tibia (HP:0005736)2.32388085
37Oligodactyly (hands) (HP:0001180)2.29661822
38Abnormal respiratory motile cilium physiology (HP:0012261)2.29595989
39Gonadotropin excess (HP:0000837)2.28748866
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28402541
413-Methylglutaconic aciduria (HP:0003535)2.28234784
42Adrenal hypoplasia (HP:0000835)2.25792749
43Hypophosphatemic rickets (HP:0004912)2.19031753
44Macrocytic anemia (HP:0001972)2.17981431
45Septo-optic dysplasia (HP:0100842)2.17977950
46Meckel diverticulum (HP:0002245)2.17672328
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.14539978
48Asplenia (HP:0001746)2.14311160
49Exertional dyspnea (HP:0002875)2.10150879
50Abnormality of the ileum (HP:0001549)2.09198996
51Median cleft lip (HP:0000161)2.08614378
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.08486683
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.07954979
54Absent/shortened dynein arms (HP:0200106)2.07954979
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05697240
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.03936986
57Lactic acidosis (HP:0003128)2.02135899
58Sclerocornea (HP:0000647)2.01523365
59Posterior subcapsular cataract (HP:0007787)1.97508302
60Absent septum pellucidum (HP:0001331)1.96328972
61Congenital malformation of the right heart (HP:0011723)1.96292624
62Double outlet right ventricle (HP:0001719)1.96292624
63Aplasia/Hypoplasia of the fovea (HP:0008060)1.95383824
64Hypoplasia of the fovea (HP:0007750)1.95383824
65Limb hypertonia (HP:0002509)1.95311773
66Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95069013
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94271153
68Abnormality of chromosome stability (HP:0003220)1.92945549
69Pancytopenia (HP:0001876)1.92695239
70Glycosuria (HP:0003076)1.91829023
71Abnormality of urine glucose concentration (HP:0011016)1.91829023
72Methylmalonic acidemia (HP:0002912)1.90307517
73Lethargy (HP:0001254)1.89726653
74Nephronophthisis (HP:0000090)1.89651331
75Exercise intolerance (HP:0003546)1.89026240
76Abnormality of the anterior horn cell (HP:0006802)1.88964431
77Degeneration of anterior horn cells (HP:0002398)1.88964431
78Abnormality of dental color (HP:0011073)1.88778025
79Sensory axonal neuropathy (HP:0003390)1.87219705
80X-linked dominant inheritance (HP:0001423)1.86857984
81Gait imbalance (HP:0002141)1.86578791
82Colon cancer (HP:0003003)1.85351718
83Increased intramyocellular lipid droplets (HP:0012240)1.84874724
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.84748823
85Infertility (HP:0000789)1.84477769
86Horseshoe kidney (HP:0000085)1.84447895
87True hermaphroditism (HP:0010459)1.83873727
88Impulsivity (HP:0100710)1.82277730
89Respiratory failure (HP:0002878)1.80216819
90Pendular nystagmus (HP:0012043)1.78802304
91Oligodactyly (HP:0012165)1.78799849
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78752426
93Rhinitis (HP:0012384)1.77811476
94Progressive inability to walk (HP:0002505)1.74309405
95Leukodystrophy (HP:0002415)1.74278970
96Parakeratosis (HP:0001036)1.74032063
97Increased serum pyruvate (HP:0003542)1.73300743
98Congenital stationary night blindness (HP:0007642)1.72825471
99Abnormality of the preputium (HP:0100587)1.72743556
100Hyperalaninemia (HP:0003348)1.72539591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.31399570
2WNK42.87331588
3PLK42.64506478
4STK392.61092433
5TRIM282.54383336
6MAP3K92.44672122
7ZAK2.33311127
8MAP3K122.30758747
9TSSK62.28352911
10TLK12.17362138
11GRK12.02991883
12BCKDK2.00122984
13VRK21.93269913
14TAOK31.92720276
15SRPK11.92343187
16STK161.90916341
17NUAK11.85130219
18PDK21.75386324
19ADRBK21.59332729
20WNK31.59153809
21BUB11.57386642
22LIMK11.52838748
23DYRK21.47128466
24INSRR1.46295708
25CDK191.43871531
26MAP4K21.43786403
27EIF2AK31.42309491
28CDC71.41175722
29ARAF1.38547344
30OXSR11.37631912
31PLK21.35405083
32NEK11.28482149
33STK241.27672711
34PLK31.26545535
35BMPR1B1.24457609
36AURKA1.23323651
37PLK11.21599954
38MAP2K61.17386634
39VRK11.13584238
40TNIK1.10855582
41TTK1.07330688
42MATK1.01772744
43LRRK20.96118358
44BRSK20.95881294
45CAMKK20.90622125
46STK38L0.88462654
47MAP3K40.88197804
48CSNK1G10.87783651
49MAPK130.87339904
50NTRK20.85429766
51MAP3K130.85202517
52MAP2K70.83040429
53PRKD30.82006511
54AURKB0.80822068
55CSNK1G30.80583789
56PIK3CA0.79926075
57BRAF0.78874364
58ATR0.77409098
59ABL20.76112379
60MKNK20.74648451
61PRKCI0.74594301
62PINK10.73991846
63CSNK1G20.73560461
64WEE10.72121134
65BRSK10.71487372
66KDR0.71460127
67PASK0.71452406
68WNK10.68747251
69PRKCG0.66277743
70CSNK1E0.65747087
71NTRK10.61795570
72CSNK1A1L0.58420071
73MOS0.57997194
74STK30.57312300
75NEK20.56455366
76CSNK2A20.55946026
77EIF2AK20.54573897
78BCR0.53018661
79TESK20.52685959
80TXK0.52089885
81FRK0.51465237
82NME10.50303699
83PAK30.49963505
84EIF2AK10.49298152
85PNCK0.49117390
86MINK10.48743199
87TIE10.47993968
88ADRBK10.46944283
89CSNK2A10.46804824
90PHKG10.46550078
91PHKG20.46550078
92PRKCE0.45964587
93DAPK10.45853685
94KSR10.43111776
95DYRK30.42983073
96PRKCQ0.42633602
97DAPK20.40705562
98PRKACA0.40350264
99PAK10.40155234
100CAMK2A0.39815489

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.44571108
2Oxidative phosphorylation_Homo sapiens_hsa001903.34541878
3Proteasome_Homo sapiens_hsa030503.00951917
4Parkinsons disease_Homo sapiens_hsa050122.99725207
5Basal transcription factors_Homo sapiens_hsa030222.45131026
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40461690
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40396526
8Steroid biosynthesis_Homo sapiens_hsa001002.32377096
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23622092
10RNA polymerase_Homo sapiens_hsa030202.23042224
11Protein export_Homo sapiens_hsa030602.15216738
12Huntingtons disease_Homo sapiens_hsa050162.15035939
13Mismatch repair_Homo sapiens_hsa034302.10778522
14RNA degradation_Homo sapiens_hsa030181.98395891
15Homologous recombination_Homo sapiens_hsa034401.98219659
16DNA replication_Homo sapiens_hsa030301.91569970
17Cardiac muscle contraction_Homo sapiens_hsa042601.90003623
18Alzheimers disease_Homo sapiens_hsa050101.87974923
19One carbon pool by folate_Homo sapiens_hsa006701.79916722
20Propanoate metabolism_Homo sapiens_hsa006401.79426915
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75629640
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71137466
23Vitamin B6 metabolism_Homo sapiens_hsa007501.70474954
24Nucleotide excision repair_Homo sapiens_hsa034201.68181576
25Base excision repair_Homo sapiens_hsa034101.65974137
26Folate biosynthesis_Homo sapiens_hsa007901.54658277
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50906589
28RNA transport_Homo sapiens_hsa030131.47453379
29Sulfur metabolism_Homo sapiens_hsa009201.42178925
30Fanconi anemia pathway_Homo sapiens_hsa034601.41898567
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39473994
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.38645806
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32377430
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28312151
35Pyrimidine metabolism_Homo sapiens_hsa002401.26290226
36Linoleic acid metabolism_Homo sapiens_hsa005911.26236897
37Butanoate metabolism_Homo sapiens_hsa006501.22394576
38Fatty acid elongation_Homo sapiens_hsa000621.21939863
39Non-homologous end-joining_Homo sapiens_hsa034501.20193276
40Phototransduction_Homo sapiens_hsa047441.19623043
41Caffeine metabolism_Homo sapiens_hsa002321.08824911
42Fat digestion and absorption_Homo sapiens_hsa049751.07964260
43Nicotine addiction_Homo sapiens_hsa050331.06994840
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03857084
45Pyruvate metabolism_Homo sapiens_hsa006201.03626075
46Collecting duct acid secretion_Homo sapiens_hsa049661.02468346
47Spliceosome_Homo sapiens_hsa030401.02343170
48Peroxisome_Homo sapiens_hsa041461.01727953
49Tryptophan metabolism_Homo sapiens_hsa003801.00323355
50Purine metabolism_Homo sapiens_hsa002300.98274840
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97063173
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94803937
53Cell cycle_Homo sapiens_hsa041100.92613441
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.87557976
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.81465554
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81429422
57Nitrogen metabolism_Homo sapiens_hsa009100.80692823
58Metabolic pathways_Homo sapiens_hsa011000.80276158
59Oocyte meiosis_Homo sapiens_hsa041140.79880104
60Ether lipid metabolism_Homo sapiens_hsa005650.79733717
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76843439
62Olfactory transduction_Homo sapiens_hsa047400.76108285
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75613071
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73264804
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72345674
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70985710
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70902109
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68006802
69Primary immunodeficiency_Homo sapiens_hsa053400.67143271
70Chemical carcinogenesis_Homo sapiens_hsa052040.67085628
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.63700043
72Arachidonic acid metabolism_Homo sapiens_hsa005900.60405301
73Glutathione metabolism_Homo sapiens_hsa004800.60279369
74Ovarian steroidogenesis_Homo sapiens_hsa049130.55210295
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54839870
76Retinol metabolism_Homo sapiens_hsa008300.54795114
77Fatty acid biosynthesis_Homo sapiens_hsa000610.54041666
78GABAergic synapse_Homo sapiens_hsa047270.52438471
79Fatty acid metabolism_Homo sapiens_hsa012120.51244900
80beta-Alanine metabolism_Homo sapiens_hsa004100.49346847
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48927373
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48810699
83p53 signaling pathway_Homo sapiens_hsa041150.46807149
84Morphine addiction_Homo sapiens_hsa050320.45527824
85Fatty acid degradation_Homo sapiens_hsa000710.43872605
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43660088
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37933643
88Regulation of autophagy_Homo sapiens_hsa041400.36237079
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34608791
90Insulin secretion_Homo sapiens_hsa049110.32712471
91Serotonergic synapse_Homo sapiens_hsa047260.32689168
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.30780685
93Arginine and proline metabolism_Homo sapiens_hsa003300.27212115
94Synaptic vesicle cycle_Homo sapiens_hsa047210.26224250
95Taste transduction_Homo sapiens_hsa047420.23651450
96Sulfur relay system_Homo sapiens_hsa041220.22746362
97mRNA surveillance pathway_Homo sapiens_hsa030150.21777524
98Vitamin digestion and absorption_Homo sapiens_hsa049770.19294114
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18130654
100Starch and sucrose metabolism_Homo sapiens_hsa005000.17533749

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