PPIAP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.68096167
2cullin deneddylation (GO:0010388)4.67965238
3DNA deamination (GO:0045006)4.66862714
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47422593
5ATP synthesis coupled proton transport (GO:0015986)4.45444894
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.45444894
7regulation of cellular amino acid metabolic process (GO:0006521)4.41275469
8respiratory chain complex IV assembly (GO:0008535)4.37605583
9maturation of SSU-rRNA (GO:0030490)4.22103822
10termination of RNA polymerase III transcription (GO:0006386)4.17006888
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.17006888
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.12699072
13protein deneddylation (GO:0000338)4.08721425
14cytidine deamination (GO:0009972)4.06620295
15cytidine metabolic process (GO:0046087)4.06620295
16cytidine catabolic process (GO:0006216)4.06620295
17DNA damage response, detection of DNA damage (GO:0042769)4.06042217
18water-soluble vitamin biosynthetic process (GO:0042364)4.04327757
19protein complex biogenesis (GO:0070271)4.00779238
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97412115
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.88844651
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83030131
23cytochrome complex assembly (GO:0017004)3.78956701
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78326021
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78326021
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.77757950
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.77757950
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.77757950
29mitochondrial respiratory chain complex assembly (GO:0033108)3.72524148
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.69070018
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66745337
32negative regulation of ligase activity (GO:0051352)3.66745337
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64454403
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.61907217
35aldehyde catabolic process (GO:0046185)3.61107288
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.58526163
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.58526163
38signal transduction involved in cell cycle checkpoint (GO:0072395)3.53398670
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52846058
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52846058
41electron transport chain (GO:0022900)3.51966789
42rRNA modification (GO:0000154)3.51054136
43respiratory electron transport chain (GO:0022904)3.50930324
44negative regulation of heart rate (GO:0010459)3.50902284
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50786895
46mannosylation (GO:0097502)3.42085464
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.41298214
48regulation of cellular respiration (GO:0043457)3.36473318
49regulation of immunoglobulin secretion (GO:0051023)3.33154744
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.32104746
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.32104746
52NADH dehydrogenase complex assembly (GO:0010257)3.32104746
53regulation of isotype switching to IgG isotypes (GO:0048302)3.27462149
54dicarboxylic acid catabolic process (GO:0043649)3.26331835
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.25203824
56chaperone-mediated protein transport (GO:0072321)3.23424817
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20070736
58regulation of podosome assembly (GO:0071801)3.18278270
59branched-chain amino acid catabolic process (GO:0009083)3.14553317
60regulation of cellular amine metabolic process (GO:0033238)3.12501327
61oxidative demethylation (GO:0070989)3.06506320
62regulation of chronic inflammatory response (GO:0002676)3.05472552
63protein-cofactor linkage (GO:0018065)3.04416567
64ribosomal large subunit biogenesis (GO:0042273)3.01113453
65translation (GO:0006412)2.99057280
66negative regulation of mast cell activation (GO:0033004)2.98549579
67antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.96421915
68positive regulation of ligase activity (GO:0051351)2.95427964
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95148162
70hydrogen ion transmembrane transport (GO:1902600)2.94906806
71rRNA methylation (GO:0031167)2.94333092
72proteasome assembly (GO:0043248)2.94196607
73regulation of meiosis I (GO:0060631)2.92004252
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91601028
75negative regulation of T-helper cell differentiation (GO:0045623)2.91601028
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90809269
77cellular component biogenesis (GO:0044085)2.88312916
78regulation of triglyceride catabolic process (GO:0010896)2.88071708
79DNA catabolic process, exonucleolytic (GO:0000738)2.87050821
80positive regulation of cell cycle arrest (GO:0071158)2.86159043
81S-adenosylmethionine metabolic process (GO:0046500)2.83010050
82negative regulation of acute inflammatory response (GO:0002674)2.79859136
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.78940417
84ribosomal small subunit biogenesis (GO:0042274)2.78382572
85cotranslational protein targeting to membrane (GO:0006613)2.76247514
86DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75580759
87proton transport (GO:0015992)2.75467890
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75031043
89positive regulation of granulocyte differentiation (GO:0030854)2.75029938
90behavioral response to nicotine (GO:0035095)2.74686737
91hydrogen transport (GO:0006818)2.72018838
92ribonucleoprotein complex biogenesis (GO:0022613)2.71777751
93histone H2A ubiquitination (GO:0033522)2.71280597
94synaptic transmission, cholinergic (GO:0007271)2.70080106
95translational termination (GO:0006415)2.70029983
96ribosome assembly (GO:0042255)2.69989348
97amino acid salvage (GO:0043102)2.67826748
98L-methionine salvage (GO:0071267)2.67826748
99L-methionine biosynthetic process (GO:0071265)2.67826748
100protein targeting to ER (GO:0045047)2.67757917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.70873582
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.44218694
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.82597097
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.72309666
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.44745232
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.97330760
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35567279
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26947294
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07936112
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89565814
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88296365
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68393835
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59771559
14ELK1_19687146_ChIP-ChIP_HELA_Human2.49433855
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.46291657
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45110278
17VDR_23849224_ChIP-Seq_CD4+_Human2.44301894
18FOXP3_21729870_ChIP-Seq_TREG_Human2.40829707
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11019129
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03041479
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95304530
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90843625
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.84492579
24DCP1A_22483619_ChIP-Seq_HELA_Human1.76402715
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65302162
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65124020
27IRF1_19129219_ChIP-ChIP_H3396_Human1.64829451
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62374441
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60542800
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60352670
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60298470
32ELK1_22589737_ChIP-Seq_MCF10A_Human1.58387182
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55799822
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.51097602
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45510988
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42155425
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40407437
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38833611
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.35397182
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35397182
41CIITA_25753668_ChIP-Seq_RAJI_Human1.35064320
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.33094390
43GABP_19822575_ChIP-Seq_HepG2_Human1.30685455
44ZNF274_21170338_ChIP-Seq_K562_Hela1.30566095
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30252042
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.29989243
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27918190
48TTF2_22483619_ChIP-Seq_HELA_Human1.27605421
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27118644
50MYC_18940864_ChIP-ChIP_HL60_Human1.26377019
51XRN2_22483619_ChIP-Seq_HELA_Human1.25920015
52GATA3_26560356_Chip-Seq_TH2_Human1.23586120
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21064556
54TP53_22573176_ChIP-Seq_HFKS_Human1.20178811
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16665054
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.15766059
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12168266
58SOX2_19829295_ChIP-Seq_ESCs_Human1.11366150
59NANOG_19829295_ChIP-Seq_ESCs_Human1.11366150
60TAF2_19829295_ChIP-Seq_ESCs_Human1.08356264
61CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07848040
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05465138
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04673207
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00332376
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99186426
66NCOR_22424771_ChIP-Seq_293T_Human0.98735886
67AR_20517297_ChIP-Seq_VCAP_Human0.98710519
68ELF1_20517297_ChIP-Seq_JURKAT_Human0.97050304
69EZH2_22144423_ChIP-Seq_EOC_Human0.95869973
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95860390
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94802166
72VDR_22108803_ChIP-Seq_LS180_Human0.94204220
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91325902
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90401428
75ERG_20517297_ChIP-Seq_VCAP_Human0.89934350
76PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89041837
77AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88538430
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87704516
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87084560
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86540541
81EWS_26573619_Chip-Seq_HEK293_Human0.84971400
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84747526
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84036315
84THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83740850
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82387188
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.81830899
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81201551
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79588182
89MYB_26560356_Chip-Seq_TH2_Human0.79336129
90KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78239456
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78224507
92PHF8_20622853_ChIP-Seq_HELA_Human0.77397237
93RBPJ_21746931_ChIP-Seq_IB4_Human0.76890871
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76144532
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75635346
96CBP_20019798_ChIP-Seq_JUKART_Human0.75601913
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75601913
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75567105
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.75280065
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75023372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.60715770
2MP0006292_abnormal_olfactory_placode3.85871813
3MP0009379_abnormal_foot_pigmentation3.81200727
4MP0004147_increased_porphyrin_level3.59759180
5MP0008875_abnormal_xenobiotic_pharmacok3.54007573
6MP0005360_urolithiasis3.32887064
7MP0000372_irregular_coat_pigmentation3.12027549
8MP0002163_abnormal_gland_morphology2.82114566
9MP0003718_maternal_effect2.65319627
10MP0001835_abnormal_antigen_presentation2.62736669
11MP0005671_abnormal_response_to2.51305204
12MP0001348_abnormal_lacrimal_gland2.49600597
13MP0001873_stomach_inflammation2.38954865
14MP0008872_abnormal_physiological_respon2.36065243
15MP0006082_CNS_inflammation2.00965087
16MP0004145_abnormal_muscle_electrophysio1.98301845
17MP0005408_hypopigmentation1.97408656
18MP0005085_abnormal_gallbladder_physiolo1.96085250
19MP0009333_abnormal_splenocyte_physiolog1.95739192
20MP0006072_abnormal_retinal_apoptosis1.94963810
21MP0003195_calcinosis1.86162762
22MP0002102_abnormal_ear_morphology1.82416274
23MP0006036_abnormal_mitochondrial_physio1.80325867
24MP0002090_abnormal_vision1.76879853
25MP0002148_abnormal_hypersensitivity_rea1.73425265
26MP0009785_altered_susceptibility_to1.71410651
27MP0003880_abnormal_central_pattern1.64337818
28MP0009697_abnormal_copulation1.62850800
29MP0005174_abnormal_tail_pigmentation1.59931273
30MP0003786_premature_aging1.52428630
31MP0002234_abnormal_pharynx_morphology1.51556612
32MP0003186_abnormal_redox_activity1.49722050
33MP0002876_abnormal_thyroid_physiology1.48487231
34MP0005379_endocrine/exocrine_gland_phen1.47707909
35MP0005332_abnormal_amino_acid1.44828239
36MP0002653_abnormal_ependyma_morphology1.40491001
37MP0002166_altered_tumor_susceptibility1.40000889
38MP0003011_delayed_dark_adaptation1.38815465
39MP0005000_abnormal_immune_tolerance1.33672605
40MP0002095_abnormal_skin_pigmentation1.32743349
41MP0002006_tumorigenesis1.32507941
42MP0005075_abnormal_melanosome_morpholog1.27074930
43MP0002138_abnormal_hepatobiliary_system1.22493590
44MP0001800_abnormal_humoral_immune1.17370192
45MP0005365_abnormal_bile_salt1.08982404
46MP0003866_abnormal_defecation1.08030172
47MP0005636_abnormal_mineral_homeostasis1.07961355
48MP0001986_abnormal_taste_sensitivity1.07296120
49MP0005187_abnormal_penis_morphology1.07153460
50MP0008007_abnormal_cellular_replicative1.06331490
51MP0003136_yellow_coat_color1.05784744
52MP0000685_abnormal_immune_system1.03462224
53MP0005395_other_phenotype1.02650042
54MP0001919_abnormal_reproductive_system1.01434106
55MP0002938_white_spotting1.01306602
56MP0002277_abnormal_respiratory_mucosa0.99931936
57MP0003724_increased_susceptibility_to0.98299171
58MP0003252_abnormal_bile_duct0.93771727
59MP0005389_reproductive_system_phenotype0.93201896
60MP0002736_abnormal_nociception_after0.91989099
61MP0001293_anophthalmia0.90642374
62MP0009764_decreased_sensitivity_to0.89298141
63MP0005551_abnormal_eye_electrophysiolog0.85961896
64MP0003646_muscle_fatigue0.84153453
65MP0002160_abnormal_reproductive_system0.83518979
66MP0001845_abnormal_inflammatory_respons0.82670095
67MP0003868_abnormal_feces_composition0.82629513
68MP0001790_abnormal_immune_system0.81326983
69MP0005387_immune_system_phenotype0.81326983
70MP0008995_early_reproductive_senescence0.80568207
71MP0002723_abnormal_immune_serum0.79747434
72MP0004019_abnormal_vitamin_homeostasis0.77418598
73MP0005084_abnormal_gallbladder_morpholo0.77250486
74MP0003693_abnormal_embryo_hatching0.75566562
75MP0001764_abnormal_homeostasis0.73913063
76MP0009046_muscle_twitch0.72523380
77MP0002693_abnormal_pancreas_physiology0.71328792
78MP0008469_abnormal_protein_level0.70116376
79MP0001819_abnormal_immune_cell0.69894519
80MP0002420_abnormal_adaptive_immunity0.69636123
81MP0003878_abnormal_ear_physiology0.68424365
82MP0005377_hearing/vestibular/ear_phenot0.68424365
83MP0005025_abnormal_response_to0.68249700
84MP0001968_abnormal_touch/_nociception0.68008986
85MP0001501_abnormal_sleep_pattern0.67028898
86MP0008058_abnormal_DNA_repair0.65649404
87MP0001905_abnormal_dopamine_level0.65638735
88MP0005253_abnormal_eye_physiology0.65492913
89MP0009643_abnormal_urine_homeostasis0.65288557
90MP0010368_abnormal_lymphatic_system0.63742624
91MP0000647_abnormal_sebaceous_gland0.63643761
92MP0003315_abnormal_perineum_morphology0.61448649
93MP0002452_abnormal_antigen_presenting0.61094189
94MP0000015_abnormal_ear_pigmentation0.59949336
95MP0001663_abnormal_digestive_system0.59683175
96MP0009745_abnormal_behavioral_response0.59126324
97MP0002132_abnormal_respiratory_system0.58971630
98MP0006035_abnormal_mitochondrial_morpho0.58486058
99MP0002398_abnormal_bone_marrow0.58094873
100MP0005584_abnormal_enzyme/coenzyme_acti0.57911461

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.54786442
2Mitochondrial inheritance (HP:0001427)4.49785733
3Acute necrotizing encephalopathy (HP:0006965)4.27549573
4Increased CSF lactate (HP:0002490)4.24112980
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.21435960
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.21435960
7Hepatocellular necrosis (HP:0001404)4.16382666
8Aplastic anemia (HP:0001915)4.16079854
9Abnormal mitochondria in muscle tissue (HP:0008316)4.12666025
10Renal Fanconi syndrome (HP:0001994)4.01552248
11Lipid accumulation in hepatocytes (HP:0006561)3.99742858
12Increased intramyocellular lipid droplets (HP:0012240)3.96558755
13Acute encephalopathy (HP:0006846)3.88179995
14Hepatic necrosis (HP:0002605)3.73876537
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.64496054
16Progressive macrocephaly (HP:0004481)3.61216414
17Exertional dyspnea (HP:0002875)3.47383528
18Increased serum lactate (HP:0002151)3.38108250
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27968348
203-Methylglutaconic aciduria (HP:0003535)3.20479331
21Increased muscle lipid content (HP:0009058)3.15913126
22Cerebral edema (HP:0002181)3.10610711
23Lactic acidosis (HP:0003128)3.03112047
24Hypoproteinemia (HP:0003075)2.94067296
25Multiple enchondromatosis (HP:0005701)2.87392329
26Decreased electroretinogram (ERG) amplitude (HP:0000654)2.80288040
27Generalized aminoaciduria (HP:0002909)2.77740174
28Glycosuria (HP:0003076)2.64204086
29Abnormality of urine glucose concentration (HP:0011016)2.64204086
30Progressive microcephaly (HP:0000253)2.63257654
31Respiratory difficulties (HP:0002880)2.58835555
32Optic neuritis (HP:0100653)2.49690875
33Retrobulbar optic neuritis (HP:0100654)2.49690875
34Type I transferrin isoform profile (HP:0003642)2.42629107
35Hyperphosphaturia (HP:0003109)2.40853004
36Abnormality of the pons (HP:0007361)2.40206209
37Abnormality of renal resorption (HP:0011038)2.37706910
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.36343775
39Exercise intolerance (HP:0003546)2.33145680
40Leukodystrophy (HP:0002415)2.32124264
41Lethargy (HP:0001254)2.29392906
42Congenital ichthyosiform erythroderma (HP:0007431)2.24249518
43True hermaphroditism (HP:0010459)2.23461840
44Optic disc pallor (HP:0000543)2.23015014
45Abnormality of the prostate (HP:0008775)2.21188998
46Respiratory failure (HP:0002878)2.17099588
47Stenosis of the external auditory canal (HP:0000402)2.16306260
48Large for gestational age (HP:0001520)2.16274983
49Clubbing of toes (HP:0100760)2.15844851
50Flat capital femoral epiphysis (HP:0003370)2.07813987
51Colon cancer (HP:0003003)2.07429331
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.03955506
53Pancreatic fibrosis (HP:0100732)2.03393849
54Pancreatic cysts (HP:0001737)2.02422248
55Myositis (HP:0100614)1.98067298
56Hypoplasia of the pons (HP:0012110)1.97004706
57Orchitis (HP:0100796)1.97004284
58Abnormal delayed hypersensitivity skin test (HP:0002963)1.96207613
59IgG deficiency (HP:0004315)1.96109513
60Type II lissencephaly (HP:0007260)1.94928523
61Oral leukoplakia (HP:0002745)1.94508894
62Meckel diverticulum (HP:0002245)1.93954707
63Abnormality of the preputium (HP:0100587)1.93448904
64Gangrene (HP:0100758)1.91677437
65CNS demyelination (HP:0007305)1.89505729
66Degeneration of anterior horn cells (HP:0002398)1.88656897
67Abnormality of the anterior horn cell (HP:0006802)1.88656897
68Methylmalonic acidemia (HP:0002912)1.87875618
69Cleft eyelid (HP:0000625)1.86708295
70Abnormality of the ileum (HP:0001549)1.85932942
71Metabolic acidosis (HP:0001942)1.85759259
72Molar tooth sign on MRI (HP:0002419)1.83579916
73Abnormality of midbrain morphology (HP:0002418)1.83579916
74X-linked dominant inheritance (HP:0001423)1.83212690
75Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80210055
76Opisthotonus (HP:0002179)1.79949295
77Athetosis (HP:0002305)1.78307363
78Chromsome breakage (HP:0040012)1.78210098
79Hyperglycinemia (HP:0002154)1.77385961
80Panhypogammaglobulinemia (HP:0003139)1.76773332
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76715808
82Abnormality of alanine metabolism (HP:0010916)1.76715808
83Hyperalaninemia (HP:0003348)1.76715808
84Congenital, generalized hypertrichosis (HP:0004540)1.76204268
85Pancytopenia (HP:0001876)1.75442275
86Pendular nystagmus (HP:0012043)1.74694443
87Abnormality of serum amino acid levels (HP:0003112)1.74273771
88Limb dystonia (HP:0002451)1.72305085
89Forearm undergrowth (HP:0009821)1.71684996
90Abnormality of cells of the erythroid lineage (HP:0012130)1.71250428
91Spastic paraparesis (HP:0002313)1.71085443
92Hypoplasia of the ulna (HP:0003022)1.68259171
93Progressive inability to walk (HP:0002505)1.68166958
94Abnormal urine phosphate concentration (HP:0012599)1.67537219
95Keratoconjunctivitis sicca (HP:0001097)1.63541972
96Hypothermia (HP:0002045)1.61374652
97Sparse eyelashes (HP:0000653)1.61054705
98Cerebellar dysplasia (HP:0007033)1.59554093
99Keratoconjunctivitis (HP:0001096)1.58418958
100Hypoalbuminemia (HP:0003073)1.58307334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.94619335
2VRK23.92937234
3MST43.81958282
4PBK3.43230129
5CDK193.26366547
6BUB13.18333812
7BMPR23.09971540
8EIF2AK12.97059022
9EIF2AK32.43707362
10TAOK32.41923890
11BCKDK2.37984188
12MUSK2.34397586
13MAP2K62.23553845
14TLK12.21359645
15OXSR12.19176951
16MAP3K122.14581805
17CDK81.84487506
18TSSK61.81208096
19VRK11.78892848
20TAF11.58016714
21MYLK1.55065400
22ZAK1.42473554
23PRKD31.41736716
24GRK11.36947518
25TXK1.34038257
26NEK11.32012800
27MAP4K21.25313077
28STK391.21748962
29DYRK21.19098065
30ADRBK21.17018976
31PLK31.13903699
32EPHA31.13484000
33WNK11.11727094
34KDR1.10295540
35NME11.08598652
36WNK41.08580213
37INSRR1.03982832
38NME21.01155032
39STK160.94191327
40EIF2AK20.88849640
41IKBKB0.76944255
42TNIK0.74135498
43DAPK10.73140276
44SRPK10.72547947
45PLK40.70731376
46PLK10.64533345
47ERBB30.64310442
48TIE10.63824115
49MAP3K140.63220723
50BMPR1B0.62059246
51PAK40.61565139
52WNK30.61391947
53CSNK1G20.60217283
54AURKB0.59749611
55CSNK1G30.59420440
56ABL20.57020296
57MARK30.55398440
58DAPK30.55155683
59PLK20.54893582
60CSNK2A20.54889291
61PAK10.53532811
62JAK30.52920774
63FLT30.52008025
64ATR0.51250857
65WEE10.50845696
66MAP3K40.50129340
67CSNK2A10.49363029
68CAMK2D0.48059659
69GRK50.47451583
70ADRBK10.45698372
71PRKCG0.45498069
72MAPKAPK50.42355406
73HIPK20.42004503
74CDK140.40544674
75PRKCQ0.40543640
76CSNK1G10.40004567
77KIT0.39707153
78LCK0.38974591
79AURKA0.38645554
80CDK11A0.38568357
81PRKCA0.38061001
82FES0.37589605
83CAMK2A0.36640185
84STK40.35854890
85ALK0.35391874
86CDC70.34837774
87ITK0.34678226
88PIK3CG0.34076958
89CSNK1A1L0.32741755
90MAPKAPK30.32076216
91STK110.31175607
92CAMKK20.30375443
93SIK30.30240088
94CDK150.29603938
95CDK180.28833589
96CSNK1A10.28294457
97CSF1R0.28248187
98OBSCN0.27587904
99LRRK20.27414114
100SMG10.27078541

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29681256
2Asthma_Homo sapiens_hsa053104.11444693
3Graft-versus-host disease_Homo sapiens_hsa053323.28540598
4Allograft rejection_Homo sapiens_hsa053303.28270961
5Autoimmune thyroid disease_Homo sapiens_hsa053203.08132512
6Ribosome_Homo sapiens_hsa030102.88656818
7RNA polymerase_Homo sapiens_hsa030202.75482764
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.73310004
9Oxidative phosphorylation_Homo sapiens_hsa001902.72289926
10One carbon pool by folate_Homo sapiens_hsa006702.46162315
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34328431
12Protein export_Homo sapiens_hsa030602.19971724
13Parkinsons disease_Homo sapiens_hsa050122.19225191
14Type I diabetes mellitus_Homo sapiens_hsa049402.17089846
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05440090
16Antigen processing and presentation_Homo sapiens_hsa046122.02528940
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71123187
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69495172
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50240151
20Propanoate metabolism_Homo sapiens_hsa006401.47056973
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38146463
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.36706049
23Huntingtons disease_Homo sapiens_hsa050161.32784294
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32586096
25Rheumatoid arthritis_Homo sapiens_hsa053231.32421719
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31431346
27Alzheimers disease_Homo sapiens_hsa050101.25928188
28Pyrimidine metabolism_Homo sapiens_hsa002401.19481886
29Homologous recombination_Homo sapiens_hsa034401.19141396
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14947321
31Butanoate metabolism_Homo sapiens_hsa006501.14578981
32Viral myocarditis_Homo sapiens_hsa054161.13577776
33Nitrogen metabolism_Homo sapiens_hsa009101.11815025
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07387080
35Mismatch repair_Homo sapiens_hsa034301.06645724
36Steroid biosynthesis_Homo sapiens_hsa001001.05506395
37Staphylococcus aureus infection_Homo sapiens_hsa051500.99350064
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99152107
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98462426
40RNA degradation_Homo sapiens_hsa030180.92084482
41Fatty acid elongation_Homo sapiens_hsa000620.91345054
42Arginine biosynthesis_Homo sapiens_hsa002200.90321704
43Hematopoietic cell lineage_Homo sapiens_hsa046400.89060467
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87104384
45Tryptophan metabolism_Homo sapiens_hsa003800.85173361
46Leishmaniasis_Homo sapiens_hsa051400.84718584
47Peroxisome_Homo sapiens_hsa041460.84374908
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84186106
49Cardiac muscle contraction_Homo sapiens_hsa042600.81065269
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.80412856
51Pyruvate metabolism_Homo sapiens_hsa006200.80308749
52Retinol metabolism_Homo sapiens_hsa008300.79109509
53Fanconi anemia pathway_Homo sapiens_hsa034600.78786567
54Chemical carcinogenesis_Homo sapiens_hsa052040.77997514
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77408240
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.76848760
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74793360
58RNA transport_Homo sapiens_hsa030130.73590063
59Carbon metabolism_Homo sapiens_hsa012000.72097632
60Fatty acid degradation_Homo sapiens_hsa000710.68534640
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68152806
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67256923
63Caffeine metabolism_Homo sapiens_hsa002320.67150955
64Base excision repair_Homo sapiens_hsa034100.66520676
65Fatty acid metabolism_Homo sapiens_hsa012120.66052685
66DNA replication_Homo sapiens_hsa030300.65471383
67Basal transcription factors_Homo sapiens_hsa030220.65351113
68Primary immunodeficiency_Homo sapiens_hsa053400.64252575
69Metabolic pathways_Homo sapiens_hsa011000.63701588
70Glutathione metabolism_Homo sapiens_hsa004800.62954073
71Collecting duct acid secretion_Homo sapiens_hsa049660.62014590
72Purine metabolism_Homo sapiens_hsa002300.59731390
73Nucleotide excision repair_Homo sapiens_hsa034200.59688026
74Spliceosome_Homo sapiens_hsa030400.56204971
75Systemic lupus erythematosus_Homo sapiens_hsa053220.55602045
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54961425
77Vitamin B6 metabolism_Homo sapiens_hsa007500.51989177
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.51213722
79Epstein-Barr virus infection_Homo sapiens_hsa051690.51044722
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50292924
81Linoleic acid metabolism_Homo sapiens_hsa005910.49508930
82Starch and sucrose metabolism_Homo sapiens_hsa005000.49003961
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46747451
84beta-Alanine metabolism_Homo sapiens_hsa004100.46441412
85Folate biosynthesis_Homo sapiens_hsa007900.43744135
86N-Glycan biosynthesis_Homo sapiens_hsa005100.43675230
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39339938
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38472247
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.37825732
90Biosynthesis of amino acids_Homo sapiens_hsa012300.37668864
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37468265
92Pentose phosphate pathway_Homo sapiens_hsa000300.34131747
93Mineral absorption_Homo sapiens_hsa049780.33549663
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33371903
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33226770
96Phototransduction_Homo sapiens_hsa047440.32977436
97Arginine and proline metabolism_Homo sapiens_hsa003300.32011867
98Tyrosine metabolism_Homo sapiens_hsa003500.31505215
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31365479
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31303430

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