PPIAP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)6.49128016
2DNA deamination (GO:0045006)5.72902667
3female mating behavior (GO:0060180)5.56371894
4response to pheromone (GO:0019236)5.33502833
5negative regulation of T cell receptor signaling pathway (GO:0050860)5.03454614
6proteasome assembly (GO:0043248)4.74694984
7behavioral response to nicotine (GO:0035095)4.70253226
8negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.55081821
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.54730083
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.54730083
11water-soluble vitamin biosynthetic process (GO:0042364)3.91073182
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.88442998
13regulation of T cell receptor signaling pathway (GO:0050856)3.81967154
14meiotic chromosome segregation (GO:0045132)3.78769153
15protein-chromophore linkage (GO:0018298)3.72922829
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.68923931
17regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.68168080
18regulation of mitotic spindle checkpoint (GO:1903504)3.68168080
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.67367185
20NADH dehydrogenase complex assembly (GO:0010257)3.67367185
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67367185
22protein complex biogenesis (GO:0070271)3.61772223
23respiratory chain complex IV assembly (GO:0008535)3.56166362
24negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.53367447
25mitochondrial respiratory chain complex assembly (GO:0033108)3.48480310
26transmission of nerve impulse (GO:0019226)3.46200804
27cytochrome complex assembly (GO:0017004)3.38181619
28protein deneddylation (GO:0000338)3.36411486
29limb bud formation (GO:0060174)3.34866196
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33737071
31isotype switching (GO:0045190)3.33737071
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33737071
33amino acid salvage (GO:0043102)3.30861913
34L-methionine salvage (GO:0071267)3.30861913
35L-methionine biosynthetic process (GO:0071265)3.30861913
36organelle disassembly (GO:1903008)3.30761066
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22290865
38cullin deneddylation (GO:0010388)3.21012909
39maturation of 5.8S rRNA (GO:0000460)3.18460421
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13531468
41pseudouridine synthesis (GO:0001522)3.12842627
42pyrimidine ribonucleoside catabolic process (GO:0046133)3.06763467
43L-fucose catabolic process (GO:0042355)3.06645751
44fucose catabolic process (GO:0019317)3.06645751
45L-fucose metabolic process (GO:0042354)3.06645751
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05826437
47indolalkylamine metabolic process (GO:0006586)3.05775687
48energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99086807
49ATP synthesis coupled proton transport (GO:0015986)2.99086807
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90693959
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90335717
52cytidine deamination (GO:0009972)2.89331716
53cytidine metabolic process (GO:0046087)2.89331716
54cytidine catabolic process (GO:0006216)2.89331716
55DNA damage response, detection of DNA damage (GO:0042769)2.87439194
56otic vesicle formation (GO:0030916)2.86570704
57nucleotide transmembrane transport (GO:1901679)2.83794524
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.83182925
59regulation of mesenchymal cell apoptotic process (GO:2001053)2.80453075
60somatic diversification of immunoglobulins (GO:0016445)2.79885778
61kynurenine metabolic process (GO:0070189)2.78739602
62dopamine transport (GO:0015872)2.77147453
63detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.76733515
64positive regulation of defense response to virus by host (GO:0002230)2.75032931
65negative regulation of heart rate (GO:0010459)2.74789607
66regulation of cellular amino acid metabolic process (GO:0006521)2.74680281
67intracellular protein transmembrane import (GO:0044743)2.73906768
68regulation of rhodopsin mediated signaling pathway (GO:0022400)2.71452194
69detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.71424987
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71186087
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70881180
72myoblast migration (GO:0051451)2.69979909
73rRNA modification (GO:0000154)2.69205476
74tRNA processing (GO:0008033)2.68265448
75regulation of immunoglobulin secretion (GO:0051023)2.67489809
76protein import into peroxisome matrix (GO:0016558)2.67010023
77S-adenosylmethionine metabolic process (GO:0046500)2.65567547
78auditory receptor cell stereocilium organization (GO:0060088)2.65148903
79metallo-sulfur cluster assembly (GO:0031163)2.64402813
80iron-sulfur cluster assembly (GO:0016226)2.64402813
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61249471
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.60728030
83signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.60728030
84signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.60728030
85protein neddylation (GO:0045116)2.59107767
86termination of RNA polymerase III transcription (GO:0006386)2.58904609
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.58904609
88ribonucleoprotein complex disassembly (GO:0032988)2.58313811
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57827492
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57663196
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57663196
92synaptic transmission, dopaminergic (GO:0001963)2.56871838
93tryptophan catabolic process (GO:0006569)2.56270166
94indole-containing compound catabolic process (GO:0042436)2.56270166
95indolalkylamine catabolic process (GO:0046218)2.56270166
96cellular ketone body metabolic process (GO:0046950)2.54855160
97positive regulation of calcium-mediated signaling (GO:0050850)2.51830025
98ncRNA catabolic process (GO:0034661)2.51143852
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.51073283
100chaperone-mediated protein transport (GO:0072321)2.50789428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15388174
2VDR_22108803_ChIP-Seq_LS180_Human3.69370494
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.35597513
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16850060
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62016565
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.49872697
7ZNF274_21170338_ChIP-Seq_K562_Hela2.46867028
8ELK1_19687146_ChIP-ChIP_HELA_Human2.44685676
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25925278
10TP53_22573176_ChIP-Seq_HFKS_Human2.17275081
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08789052
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.07211615
13VDR_23849224_ChIP-Seq_CD4+_Human2.04147316
14EZH2_22144423_ChIP-Seq_EOC_Human1.97728520
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97074250
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.96668863
17GBX2_23144817_ChIP-Seq_PC3_Human1.82319140
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81845946
19FUS_26573619_Chip-Seq_HEK293_Human1.80887016
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80577193
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78114187
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.77749224
23MYC_18940864_ChIP-ChIP_HL60_Human1.74000913
24EWS_26573619_Chip-Seq_HEK293_Human1.70810214
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69571447
26P300_19829295_ChIP-Seq_ESCs_Human1.65286371
27AR_21572438_ChIP-Seq_LNCaP_Human1.60890062
28HOXB7_26014856_ChIP-Seq_BT474_Human1.59938226
29IGF1R_20145208_ChIP-Seq_DFB_Human1.59857242
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55174040
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54770425
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53407964
33ER_23166858_ChIP-Seq_MCF-7_Human1.51451793
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46298416
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44639618
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44639618
37FOXP3_21729870_ChIP-Seq_TREG_Human1.41629912
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.39990032
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36605677
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36174746
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.36174746
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35295660
43SOX2_19829295_ChIP-Seq_ESCs_Human1.34414139
44NANOG_19829295_ChIP-Seq_ESCs_Human1.34414139
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32849160
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29941362
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29826073
48TAF15_26573619_Chip-Seq_HEK293_Human1.27523190
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26874221
50GATA3_26560356_Chip-Seq_TH2_Human1.26281145
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24986098
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24925529
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24495275
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.24099575
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23754401
56PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23396778
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22350914
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22152944
59NCOR_22424771_ChIP-Seq_293T_Human1.20153147
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16411743
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14362830
62TCF4_22108803_ChIP-Seq_LS180_Human1.13394270
63STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12202454
64AR_20517297_ChIP-Seq_VCAP_Human1.12054367
65PHF8_20622853_ChIP-Seq_HELA_Human1.11407929
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.11297428
67MYC_19829295_ChIP-Seq_ESCs_Human1.10339849
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09579653
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08965124
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08028458
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.07069432
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06672227
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06473454
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06397029
75CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06060821
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.05848382
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.04333362
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03607950
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02089921
80TCF4_23295773_ChIP-Seq_U87_Human1.01487327
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01209332
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.00726861
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00403443
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99249217
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98949055
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98844274
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98556242
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.97835525
89RBPJ_21746931_ChIP-Seq_IB4_Human0.97303096
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96896663
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95985821
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.95823080
93BCAT_22108803_ChIP-Seq_LS180_Human0.95561439
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95182405
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94883169
96SMAD4_21799915_ChIP-Seq_A2780_Human0.94808977
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94704464
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94673303
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94620103
100ERA_21632823_ChIP-Seq_H3396_Human0.93991424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.40256712
2MP0003136_yellow_coat_color4.36809557
3MP0002102_abnormal_ear_morphology3.88789737
4MP0002132_abnormal_respiratory_system3.43670667
5MP0002163_abnormal_gland_morphology3.39868637
6MP0006072_abnormal_retinal_apoptosis2.85026281
7MP0002277_abnormal_respiratory_mucosa2.60294524
8MP0009780_abnormal_chondrocyte_physiolo2.48978106
9MP0003787_abnormal_imprinting2.30584540
10MP0002138_abnormal_hepatobiliary_system2.28548617
11MP0005084_abnormal_gallbladder_morpholo2.28476348
12MP0008877_abnormal_DNA_methylation2.24961609
13MP0008875_abnormal_xenobiotic_pharmacok2.11680064
14MP0006292_abnormal_olfactory_placode2.10621711
15MP0005379_endocrine/exocrine_gland_phen2.06879724
16MP0003195_calcinosis1.86326407
17MP0001485_abnormal_pinna_reflex1.75499066
18MP0005671_abnormal_response_to1.68691812
19MP0004885_abnormal_endolymph1.68462688
20MP0005253_abnormal_eye_physiology1.66994975
21MP0003646_muscle_fatigue1.61486531
22MP0001986_abnormal_taste_sensitivity1.61248301
23MP0003283_abnormal_digestive_organ1.59030720
24MP0002282_abnormal_trachea_morphology1.53559981
25MP0004147_increased_porphyrin_level1.53030427
26MP0009333_abnormal_splenocyte_physiolog1.52165172
27MP0001293_anophthalmia1.51458997
28MP0004742_abnormal_vestibular_system1.49811379
29MP0006276_abnormal_autonomic_nervous1.48617959
30MP0005551_abnormal_eye_electrophysiolog1.47866048
31MP0008775_abnormal_heart_ventricle1.45729981
32MP0001984_abnormal_olfaction1.40893412
33MP0001529_abnormal_vocalization1.40590062
34MP0008872_abnormal_physiological_respon1.35654879
35MP0000569_abnormal_digit_pigmentation1.33730172
36MP0004381_abnormal_hair_follicle1.33161475
37MP0002653_abnormal_ependyma_morphology1.31256107
38MP0003938_abnormal_ear_development1.31203423
39MP0005645_abnormal_hypothalamus_physiol1.29730832
40MP0003879_abnormal_hair_cell1.25007907
41MP0005503_abnormal_tendon_morphology1.22742438
42MP0003718_maternal_effect1.19943303
43MP0000685_abnormal_immune_system1.19107582
44MP0001968_abnormal_touch/_nociception1.18641695
45MP0004133_heterotaxia1.15941758
46MP0000049_abnormal_middle_ear1.14910977
47MP0002837_dystrophic_cardiac_calcinosis1.14058166
48MP0002736_abnormal_nociception_after1.09922600
49MP0010386_abnormal_urinary_bladder1.08679805
50MP0003693_abnormal_embryo_hatching1.06296290
51MP0002876_abnormal_thyroid_physiology1.05232112
52MP0000613_abnormal_salivary_gland1.03599783
53MP0001764_abnormal_homeostasis1.01303398
54MP0003123_paternal_imprinting1.00556053
55MP0009046_muscle_twitch1.00419154
56MP0003880_abnormal_central_pattern0.99797018
57MP0009250_abnormal_appendicular_skeleto0.97613825
58MP0002234_abnormal_pharynx_morphology0.95389863
59MP0003786_premature_aging0.94950725
60MP0000647_abnormal_sebaceous_gland0.92595591
61MP0002928_abnormal_bile_duct0.92516135
62MP0000230_abnormal_systemic_arterial0.90481901
63MP0003567_abnormal_fetal_cardiomyocyte0.90383043
64MP0002272_abnormal_nervous_system0.90022080
65MP0002909_abnormal_adrenal_gland0.89422068
66MP0002751_abnormal_autonomic_nervous0.87089328
67MP0000026_abnormal_inner_ear0.85532460
68MP0005410_abnormal_fertilization0.84856986
69MP0003878_abnormal_ear_physiology0.84647023
70MP0005377_hearing/vestibular/ear_phenot0.84647023
71MP0009785_altered_susceptibility_to0.84453454
72MP0005391_vision/eye_phenotype0.83636964
73MP0002210_abnormal_sex_determination0.83345761
74MP0002233_abnormal_nose_morphology0.83343106
75MP0005387_immune_system_phenotype0.82841788
76MP0001790_abnormal_immune_system0.82841788
77MP0003866_abnormal_defecation0.81775687
78MP0001501_abnormal_sleep_pattern0.80468221
79MP0001905_abnormal_dopamine_level0.80169758
80MP0002638_abnormal_pupillary_reflex0.78760456
81MP0005075_abnormal_melanosome_morpholog0.77915616
82MP0000383_abnormal_hair_follicle0.76738619
83MP0003119_abnormal_digestive_system0.76272254
84MP0001963_abnormal_hearing_physiology0.75802375
85MP0000631_abnormal_neuroendocrine_gland0.75064016
86MP0001486_abnormal_startle_reflex0.74943362
87MP0001800_abnormal_humoral_immune0.74755257
88MP0004215_abnormal_myocardial_fiber0.73734739
89MP0005187_abnormal_penis_morphology0.73446880
90MP0009745_abnormal_behavioral_response0.72762340
91MP0002733_abnormal_thermal_nociception0.72755437
92MP0001502_abnormal_circadian_rhythm0.72738506
93MP0008995_early_reproductive_senescence0.70581932
94MP0002752_abnormal_somatic_nervous0.69034261
95MP0006036_abnormal_mitochondrial_physio0.68987956
96MP0000681_abnormal_thyroid_gland0.68496042
97MP0009764_decreased_sensitivity_to0.66539674
98MP0003137_abnormal_impulse_conducting0.65722594
99MP0004142_abnormal_muscle_tone0.65037394
100MP0003763_abnormal_thymus_physiology0.64024579

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.85949298
2Abnormal rod and cone electroretinograms (HP:0008323)4.65032511
3Acute necrotizing encephalopathy (HP:0006965)3.85105267
4Concave nail (HP:0001598)3.80052663
5Mitochondrial inheritance (HP:0001427)3.70111010
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.68250187
7Increased CSF lactate (HP:0002490)3.64889818
8True hermaphroditism (HP:0010459)3.57915377
9Abnormality of midbrain morphology (HP:0002418)3.56361374
10Molar tooth sign on MRI (HP:0002419)3.56361374
11Acute encephalopathy (HP:0006846)3.51630212
12Increased hepatocellular lipid droplets (HP:0006565)3.50346474
13Stomatitis (HP:0010280)3.41712330
14Progressive macrocephaly (HP:0004481)3.31737190
15Abnormal mitochondria in muscle tissue (HP:0008316)3.30712120
16Pancreatic cysts (HP:0001737)3.21636447
17Anhidrosis (HP:0000970)3.14918720
18Type II lissencephaly (HP:0007260)3.14899028
19Lipid accumulation in hepatocytes (HP:0006561)3.07185778
20Cerebellar dysplasia (HP:0007033)2.99624834
21Chronic hepatic failure (HP:0100626)2.98391790
22Tubular atrophy (HP:0000092)2.90184699
23Decreased central vision (HP:0007663)2.89146781
24Mesangial abnormality (HP:0001966)2.80763437
253-Methylglutaconic aciduria (HP:0003535)2.77263572
26Abnormality of macular pigmentation (HP:0008002)2.74119130
27Neonatal respiratory distress (HP:0002643)2.73236183
28Hepatocellular necrosis (HP:0001404)2.66997344
29Pancreatic fibrosis (HP:0100732)2.65329183
30Respiratory difficulties (HP:0002880)2.59264889
31Volvulus (HP:0002580)2.58348372
32Hypoproteinemia (HP:0003075)2.52242841
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46610047
34Optic disc pallor (HP:0000543)2.45006677
35Severe visual impairment (HP:0001141)2.41477185
36Increased serum lactate (HP:0002151)2.38684872
37Long clavicles (HP:0000890)2.36999703
38IgG deficiency (HP:0004315)2.35943203
39Increased intramyocellular lipid droplets (HP:0012240)2.33735892
40Nephronophthisis (HP:0000090)2.32992874
41Attenuation of retinal blood vessels (HP:0007843)2.32642283
42Abnormality of the fovea (HP:0000493)2.30036103
43Type 2 muscle fiber atrophy (HP:0003554)2.27017588
4411 pairs of ribs (HP:0000878)2.25694004
45Hypoplasia of the fovea (HP:0007750)2.24390079
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.24390079
47Hepatic necrosis (HP:0002605)2.24002473
48Bony spicule pigmentary retinopathy (HP:0007737)2.20983282
49Cerebral edema (HP:0002181)2.18779267
50Metaphyseal dysplasia (HP:0100255)2.16879033
51Renal Fanconi syndrome (HP:0001994)2.14898708
52Conical tooth (HP:0000698)2.13133437
53Abnormality of the renal cortex (HP:0011035)2.12770753
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09592789
55Exertional dyspnea (HP:0002875)2.09489254
56Abnormality of alanine metabolism (HP:0010916)2.08474704
57Hyperalaninemia (HP:0003348)2.08474704
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08474704
59Renal cortical cysts (HP:0000803)2.07822510
60Pigmentary retinal degeneration (HP:0001146)2.06114491
61Retinal dysplasia (HP:0007973)2.01956667
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01340866
63Aplasia/hypoplasia of the uterus (HP:0008684)1.99669523
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98798271
65Muscle fiber atrophy (HP:0100295)1.97416636
66Lactic acidosis (HP:0003128)1.96364492
67Male pseudohermaphroditism (HP:0000037)1.95792799
68Sclerocornea (HP:0000647)1.95390945
69Optic nerve hypoplasia (HP:0000609)1.94867691
70Bile duct proliferation (HP:0001408)1.94206321
71Abnormal biliary tract physiology (HP:0012439)1.94206321
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92851783
73Keratoconjunctivitis sicca (HP:0001097)1.90618741
74Palpitations (HP:0001962)1.89134984
75Pendular nystagmus (HP:0012043)1.89116107
76Thyroiditis (HP:0100646)1.88761506
77Abnormality of T cells (HP:0002843)1.87277863
78Keratoconjunctivitis (HP:0001096)1.86664082
79Poor speech (HP:0002465)1.86449959
80Abnormality of T cell physiology (HP:0011840)1.85116295
81Carpal bone hypoplasia (HP:0001498)1.84428197
82Abnormal drinking behavior (HP:0030082)1.83982559
83Polydipsia (HP:0001959)1.83982559
84Severe combined immunodeficiency (HP:0004430)1.80951730
85Anencephaly (HP:0002323)1.80493621
86Elevated erythrocyte sedimentation rate (HP:0003565)1.80291070
87Pustule (HP:0200039)1.79896216
88Methylmalonic aciduria (HP:0012120)1.78438503
89Cystic liver disease (HP:0006706)1.77961104
90Limb dystonia (HP:0002451)1.76534508
91Hypoplastic iliac wings (HP:0002866)1.75453172
92Dysphonia (HP:0001618)1.75031059
93CNS demyelination (HP:0007305)1.74591682
94Congenital, generalized hypertrichosis (HP:0004540)1.73666460
95Increased muscle lipid content (HP:0009058)1.73277908
96Hypothermia (HP:0002045)1.73148698
97Postaxial foot polydactyly (HP:0001830)1.72450417
98Abnormal albumin level (HP:0012116)1.72381155
99Hypoalbuminemia (HP:0003073)1.72381155
100Abnormality of the renal medulla (HP:0100957)1.71534293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.60407414
2ADRBK23.39347292
3TXK2.74095036
4BUB12.72219567
5VRK22.37422806
6MST42.30775480
7NEK12.28943400
8TAF12.16651618
9MKNK22.15670525
10EIF2AK32.12406614
11GRK12.08712137
12WNK42.02686829
13TSSK62.02649276
14MKNK11.86973145
15ZAK1.86054830
16NUAK11.83862345
17WNK31.83467991
18MAP4K21.71019264
19STK391.60741709
20MAPKAPK31.59877646
21CLK11.56477312
22EIF2AK11.55780942
23PDK21.54169585
24KDR1.53708608
25PLK21.51115060
26BCR1.48001084
27BCKDK1.47284146
28MUSK1.44020250
29OXSR11.40050508
30SRPK11.36832232
31CSNK1G11.35303229
32STK38L1.34002294
33TESK21.32048284
34DAPK21.26216754
35PLK41.24241992
36KIT1.24234376
37CSNK1G31.22733526
38DYRK21.16775263
39PINK11.11901738
40ALK1.10139411
41ADRBK11.10123415
42CSNK1G21.08019389
43STK161.07354153
44VRK11.00245434
45PLK30.96143643
46TEC0.93587733
47FES0.90990424
48TLK10.89192026
49GRK70.85027560
50INSRR0.84900009
51CSNK1A1L0.83400019
52NLK0.82490860
53MAPKAPK50.81296666
54LIMK10.80855521
55MINK10.79392395
56ITK0.77941120
57MAPK130.75388758
58GRK50.75347648
59RPS6KA50.74003879
60PAK30.72549837
61MAP3K120.69155895
62RPS6KA40.69134541
63PRKCQ0.69019077
64MAP4K10.68603175
65LCK0.67946706
66SYK0.67357397
67TNIK0.60768133
68MAP2K60.60260773
69PRKCE0.58823545
70BMPR1B0.57966784
71AURKB0.57584012
72CAMK2A0.54014146
73CDK140.53508517
74TAOK30.50503409
75TRIM280.49763934
76MAP2K70.49704890
77NME10.48697645
78CSNK2A10.47893410
79PRKCI0.46783412
80ERBB20.46565764
81EIF2AK20.45991154
82SCYL20.45555721
83CSNK1A10.44613231
84IGF1R0.43256595
85ROCK10.42383524
86PRKCA0.42043047
87PLK10.41619309
88CDK11A0.41186695
89CDK180.39049938
90ABL10.38620084
91OBSCN0.38485635
92MYLK0.38181759
93STK240.37741202
94TESK10.37537170
95DAPK10.37111882
96PRKG20.36936759
97CDK150.36699233
98PRKACA0.36339088
99PIK3CG0.35316105
100LYN0.34935612

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.13881961
2Caffeine metabolism_Homo sapiens_hsa002323.07872509
3Oxidative phosphorylation_Homo sapiens_hsa001902.78099770
4Protein export_Homo sapiens_hsa030602.72318614
5Primary immunodeficiency_Homo sapiens_hsa053402.54377818
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48390328
7Parkinsons disease_Homo sapiens_hsa050122.44382849
8RNA polymerase_Homo sapiens_hsa030202.40289049
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28821843
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15684230
11Homologous recombination_Homo sapiens_hsa034401.82542865
12Phototransduction_Homo sapiens_hsa047441.81905697
13Linoleic acid metabolism_Homo sapiens_hsa005911.76764687
14Basal transcription factors_Homo sapiens_hsa030221.73330023
15Ribosome_Homo sapiens_hsa030101.70448058
16Tryptophan metabolism_Homo sapiens_hsa003801.70444208
17One carbon pool by folate_Homo sapiens_hsa006701.68699928
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67870987
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66295054
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63557764
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63158797
22Huntingtons disease_Homo sapiens_hsa050161.61945258
23Nitrogen metabolism_Homo sapiens_hsa009101.53263722
24Mismatch repair_Homo sapiens_hsa034301.51374574
25RNA degradation_Homo sapiens_hsa030181.50799536
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50562034
27Olfactory transduction_Homo sapiens_hsa047401.47353989
28Alzheimers disease_Homo sapiens_hsa050101.40776575
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36185798
30Butanoate metabolism_Homo sapiens_hsa006501.28464948
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26459851
32Peroxisome_Homo sapiens_hsa041461.18820934
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18583407
34Pyrimidine metabolism_Homo sapiens_hsa002401.12294634
35Cardiac muscle contraction_Homo sapiens_hsa042601.11655413
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07408173
37Asthma_Homo sapiens_hsa053101.03526522
38Chemical carcinogenesis_Homo sapiens_hsa052041.03514621
39Purine metabolism_Homo sapiens_hsa002301.03473716
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02873134
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.02422581
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01911234
43Allograft rejection_Homo sapiens_hsa053301.01840907
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.00255512
45Spliceosome_Homo sapiens_hsa030400.98902366
46RNA transport_Homo sapiens_hsa030130.96708623
47Regulation of autophagy_Homo sapiens_hsa041400.95321354
48Ether lipid metabolism_Homo sapiens_hsa005650.94175295
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93380756
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93299418
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90766456
52Autoimmune thyroid disease_Homo sapiens_hsa053200.88136795
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85881374
54Sulfur metabolism_Homo sapiens_hsa009200.84737694
55Hematopoietic cell lineage_Homo sapiens_hsa046400.82487433
56Rheumatoid arthritis_Homo sapiens_hsa053230.82255076
57Nicotine addiction_Homo sapiens_hsa050330.81659080
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.80398267
59Steroid biosynthesis_Homo sapiens_hsa001000.78969772
60Retinol metabolism_Homo sapiens_hsa008300.78894788
61Arginine and proline metabolism_Homo sapiens_hsa003300.78293307
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75085630
63Salivary secretion_Homo sapiens_hsa049700.74748690
64Propanoate metabolism_Homo sapiens_hsa006400.73674521
65Antigen processing and presentation_Homo sapiens_hsa046120.72434920
66Taste transduction_Homo sapiens_hsa047420.69886365
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69848939
68Nucleotide excision repair_Homo sapiens_hsa034200.68036050
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.66566715
70beta-Alanine metabolism_Homo sapiens_hsa004100.65416914
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.65304438
72Arachidonic acid metabolism_Homo sapiens_hsa005900.65244582
73Fat digestion and absorption_Homo sapiens_hsa049750.63935914
74Metabolic pathways_Homo sapiens_hsa011000.63019683
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62985682
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.60699860
77Fanconi anemia pathway_Homo sapiens_hsa034600.59280071
78DNA replication_Homo sapiens_hsa030300.59016074
79Morphine addiction_Homo sapiens_hsa050320.54712221
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53304350
81T cell receptor signaling pathway_Homo sapiens_hsa046600.51481341
82Base excision repair_Homo sapiens_hsa034100.48842031
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.45675563
84Graft-versus-host disease_Homo sapiens_hsa053320.45453355
85Type I diabetes mellitus_Homo sapiens_hsa049400.44907320
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43392537
87Vitamin B6 metabolism_Homo sapiens_hsa007500.42549827
88Calcium signaling pathway_Homo sapiens_hsa040200.41733980
89Non-homologous end-joining_Homo sapiens_hsa034500.41711980
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39711327
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38170726
92Fatty acid degradation_Homo sapiens_hsa000710.37302113
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35627836
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34086666
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31990549
96Tyrosine metabolism_Homo sapiens_hsa003500.31672784
97Circadian entrainment_Homo sapiens_hsa047130.30834847
98Collecting duct acid secretion_Homo sapiens_hsa049660.30393878
99Glycerolipid metabolism_Homo sapiens_hsa005610.30221188
100mRNA surveillance pathway_Homo sapiens_hsa030150.30018972

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