PPIAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.75082004
2proteasome assembly (GO:0043248)4.45017715
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33094857
4cullin deneddylation (GO:0010388)4.11590727
5protein deneddylation (GO:0000338)3.97695016
6pyrimidine nucleobase catabolic process (GO:0006208)3.92758668
7regulation of mitotic spindle checkpoint (GO:1903504)3.85138537
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.85138537
9protein complex biogenesis (GO:0070271)3.66063341
10protein polyglutamylation (GO:0018095)3.65732220
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58369562
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56341251
13protein neddylation (GO:0045116)3.54921887
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54621004
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.53388223
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49451613
17cytidine metabolic process (GO:0046087)3.48076998
18cytidine catabolic process (GO:0006216)3.48076998
19cytidine deamination (GO:0009972)3.48076998
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43556262
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.43556262
22NADH dehydrogenase complex assembly (GO:0010257)3.43556262
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42838378
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42400306
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.42400306
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.41551762
27mitochondrial respiratory chain complex assembly (GO:0033108)3.39468494
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37207231
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.35518833
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.35518833
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.35518833
32response to pheromone (GO:0019236)3.35071179
33regulation of cellular amino acid metabolic process (GO:0006521)3.31340159
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.31316277
35termination of RNA polymerase III transcription (GO:0006386)3.31316277
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31228784
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31228784
38ATP synthesis coupled proton transport (GO:0015986)3.28432924
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28432924
40regulation of cilium movement (GO:0003352)3.28391978
41iron-sulfur cluster assembly (GO:0016226)3.27846124
42metallo-sulfur cluster assembly (GO:0031163)3.27846124
43RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.24552286
44rRNA modification (GO:0000154)3.22794962
45pyrimidine ribonucleoside catabolic process (GO:0046133)3.22358625
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.21517139
47DNA damage response, detection of DNA damage (GO:0042769)3.21242671
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18510676
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18510676
50aldehyde catabolic process (GO:0046185)3.17510888
51nucleobase catabolic process (GO:0046113)3.16207386
52signal transduction involved in DNA damage checkpoint (GO:0072422)3.15343357
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15343357
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09697937
55negative regulation of ligase activity (GO:0051352)3.08591695
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08591695
57DNA catabolic process, exonucleolytic (GO:0000738)3.08018270
58chromatin remodeling at centromere (GO:0031055)3.07888856
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06406639
60respiratory chain complex IV assembly (GO:0008535)3.05816886
61CENP-A containing nucleosome assembly (GO:0034080)3.00724632
62replication fork processing (GO:0031297)3.00260695
63peptidyl-histidine modification (GO:0018202)2.94746216
64male meiosis I (GO:0007141)2.94415333
65histone exchange (GO:0043486)2.91335188
66deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89322207
67synapsis (GO:0007129)2.87430137
68piRNA metabolic process (GO:0034587)2.87283486
69chaperone-mediated protein transport (GO:0072321)2.86545847
70mannosylation (GO:0097502)2.86474995
71cytochrome complex assembly (GO:0017004)2.82473201
72regulation of glutamate secretion (GO:0014048)2.79043451
73somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78869625
74somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78869625
75isotype switching (GO:0045190)2.78869625
76protein-cofactor linkage (GO:0018065)2.77829116
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76671826
78meiosis I (GO:0007127)2.75290959
79histone H2A acetylation (GO:0043968)2.74782720
80platelet dense granule organization (GO:0060155)2.74067255
81preassembly of GPI anchor in ER membrane (GO:0016254)2.72478172
82pseudouridine synthesis (GO:0001522)2.71887543
83electron transport chain (GO:0022900)2.69159942
84respiratory electron transport chain (GO:0022904)2.68622356
85DNA double-strand break processing (GO:0000729)2.63945507
86positive regulation of ligase activity (GO:0051351)2.62749159
87cilium morphogenesis (GO:0060271)2.61638002
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.61292227
89negative regulation of telomere maintenance (GO:0032205)2.57977173
90protein prenylation (GO:0018342)2.57770497
91prenylation (GO:0097354)2.57770497
92postreplication repair (GO:0006301)2.56375426
93tRNA processing (GO:0008033)2.56361887
94telomere maintenance via semi-conservative replication (GO:0032201)2.56072938
95adenosine metabolic process (GO:0046085)2.55715574
96nucleobase biosynthetic process (GO:0046112)2.54564928
97presynaptic membrane assembly (GO:0097105)2.54419405
98rRNA methylation (GO:0031167)2.53102150
99GPI anchor metabolic process (GO:0006505)2.52526558
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.50353995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53978457
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.54585668
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.26634289
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.17029404
5ZNF274_21170338_ChIP-Seq_K562_Hela2.99410244
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.90345566
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86305187
8VDR_22108803_ChIP-Seq_LS180_Human2.82321947
9IGF1R_20145208_ChIP-Seq_DFB_Human2.75639449
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52852308
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42558724
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42149783
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34607445
14VDR_23849224_ChIP-Seq_CD4+_Human2.33715670
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.33043877
16E2F7_22180533_ChIP-Seq_HELA_Human2.27075837
17ELK1_19687146_ChIP-ChIP_HELA_Human2.26366654
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.12374892
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11632957
20EWS_26573619_Chip-Seq_HEK293_Human2.09692123
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09335201
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99564459
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97429652
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.94591924
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93455410
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93187975
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.90903565
28P300_19829295_ChIP-Seq_ESCs_Human1.83383977
29FOXP3_21729870_ChIP-Seq_TREG_Human1.83136346
30TAF15_26573619_Chip-Seq_HEK293_Human1.75627327
31FUS_26573619_Chip-Seq_HEK293_Human1.75619737
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74226839
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.71812826
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60663645
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58547381
36MYC_18940864_ChIP-ChIP_HL60_Human1.57078707
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52358283
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51897766
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51052774
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48005918
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45463789
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.44043641
43TP53_22573176_ChIP-Seq_HFKS_Human1.42743851
44GBX2_23144817_ChIP-Seq_PC3_Human1.40397469
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.38822686
46ER_23166858_ChIP-Seq_MCF-7_Human1.36417126
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34723998
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32525186
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32099840
50NANOG_19829295_ChIP-Seq_ESCs_Human1.29699763
51SOX2_19829295_ChIP-Seq_ESCs_Human1.29699763
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27277122
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27098367
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26940001
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24981199
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24195389
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.23156159
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20006920
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19366145
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16606799
61CBP_20019798_ChIP-Seq_JUKART_Human1.16606799
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14997608
63BCAT_22108803_ChIP-Seq_LS180_Human1.14925232
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13873322
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.11307118
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09793786
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06882064
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06701187
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06278113
70DCP1A_22483619_ChIP-Seq_HELA_Human1.04892560
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04855695
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03932784
73GABP_19822575_ChIP-Seq_HepG2_Human1.03017029
74TCF4_22108803_ChIP-Seq_LS180_Human1.02208686
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00509980
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00352175
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.00352175
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00189121
79P53_22387025_ChIP-Seq_ESCs_Mouse0.97672109
80NCOR_22424771_ChIP-Seq_293T_Human0.97393994
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96126888
82MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95864072
83MYC_18555785_ChIP-Seq_MESCs_Mouse0.95604477
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94144193
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93276057
86STAT3_18555785_Chip-Seq_ESCs_Mouse0.92719674
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91079325
88MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90488374
89PHF8_20622853_ChIP-Seq_HELA_Human0.90468049
90IRF1_19129219_ChIP-ChIP_H3396_Human0.90266131
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90077267
92AR_20517297_ChIP-Seq_VCAP_Human0.89568888
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89417957
94P300_18555785_Chip-Seq_ESCs_Mouse0.89269143
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88905787
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.88329994
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88093141
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87292480
99RBPJ_21746931_ChIP-Seq_IB4_Human0.87240362
100ETV1_20927104_ChIP-Seq_GIST48_Human0.86912190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.37384755
2MP0004147_increased_porphyrin_level3.19071528
3MP0000372_irregular_coat_pigmentation3.06306644
4MP0008058_abnormal_DNA_repair3.02328859
5MP0002736_abnormal_nociception_after2.97196894
6MP0008877_abnormal_DNA_methylation2.95881828
7MP0001968_abnormal_touch/_nociception2.65546614
8MP0005671_abnormal_response_to2.55704958
9MP0001529_abnormal_vocalization2.35623711
10MP0006072_abnormal_retinal_apoptosis2.31661229
11MP0005551_abnormal_eye_electrophysiolog2.30293236
12MP0001984_abnormal_olfaction2.29673027
13MP0003806_abnormal_nucleotide_metabolis2.11772858
14MP0010094_abnormal_chromosome_stability2.11640511
15MP0008789_abnormal_olfactory_epithelium2.08335560
16MP0008872_abnormal_physiological_respon2.07184388
17MP0006276_abnormal_autonomic_nervous1.96624913
18MP0005360_urolithiasis1.95114565
19MP0005075_abnormal_melanosome_morpholog1.90067884
20MP0005253_abnormal_eye_physiology1.87413986
21MP0003718_maternal_effect1.78881545
22MP0003880_abnormal_central_pattern1.72221735
23MP0008057_abnormal_DNA_replication1.65798182
24MP0003693_abnormal_embryo_hatching1.64624173
25MP0006292_abnormal_olfactory_placode1.54437125
26MP0001986_abnormal_taste_sensitivity1.51280631
27MP0001485_abnormal_pinna_reflex1.50128991
28MP0006035_abnormal_mitochondrial_morpho1.47595403
29MP0002272_abnormal_nervous_system1.45655911
30MP0006036_abnormal_mitochondrial_physio1.43114969
31MP0005499_abnormal_olfactory_system1.41396797
32MP0005394_taste/olfaction_phenotype1.41396797
33MP0004142_abnormal_muscle_tone1.37944708
34MP0005084_abnormal_gallbladder_morpholo1.37801334
35MP0003786_premature_aging1.35301853
36MP0001486_abnormal_startle_reflex1.35233320
37MP0001188_hyperpigmentation1.34285320
38MP0002938_white_spotting1.31068972
39MP0002751_abnormal_autonomic_nervous1.28779561
40MP0003787_abnormal_imprinting1.24046804
41MP0002095_abnormal_skin_pigmentation1.23860412
42MP0003011_delayed_dark_adaptation1.21616056
43MP0002638_abnormal_pupillary_reflex1.21543319
44MP0004742_abnormal_vestibular_system1.17294282
45MP0003136_yellow_coat_color1.16786214
46MP0009046_muscle_twitch1.15350563
47MP0004957_abnormal_blastocyst_morpholog1.14472836
48MP0003195_calcinosis1.13291891
49MP0009745_abnormal_behavioral_response1.12717306
50MP0009697_abnormal_copulation1.11580222
51MP0002210_abnormal_sex_determination1.11446684
52MP0001929_abnormal_gametogenesis1.10967026
53MP0005377_hearing/vestibular/ear_phenot1.10523930
54MP0003878_abnormal_ear_physiology1.10523930
55MP0005645_abnormal_hypothalamus_physiol1.09848739
56MP0003121_genomic_imprinting1.08114335
57MP0001119_abnormal_female_reproductive1.07924005
58MP0003567_abnormal_fetal_cardiomyocyte1.03532913
59MP0000427_abnormal_hair_cycle1.02435468
60MP0001835_abnormal_antigen_presentation0.99586290
61MP0002557_abnormal_social/conspecific_i0.98396981
62MP0001970_abnormal_pain_threshold0.98081593
63MP0005171_absent_coat_pigmentation0.95693828
64MP0003646_muscle_fatigue0.95450860
65MP0001919_abnormal_reproductive_system0.94774788
66MP0002163_abnormal_gland_morphology0.94749010
67MP0000653_abnormal_sex_gland0.93924852
68MP0003137_abnormal_impulse_conducting0.93816278
69MP0008875_abnormal_xenobiotic_pharmacok0.92592384
70MP0002735_abnormal_chemical_nociception0.92144910
71MP0005410_abnormal_fertilization0.91961466
72MP0003698_abnormal_male_reproductive0.90983315
73MP0008995_early_reproductive_senescence0.90969334
74MP0005389_reproductive_system_phenotype0.90761456
75MP0001145_abnormal_male_reproductive0.90363217
76MP0005379_endocrine/exocrine_gland_phen0.89584829
77MP0003111_abnormal_nucleus_morphology0.89213346
78MP0000015_abnormal_ear_pigmentation0.88357928
79MP0002837_dystrophic_cardiac_calcinosis0.86249070
80MP0003186_abnormal_redox_activity0.86013811
81MP0004924_abnormal_behavior0.84603675
82MP0005386_behavior/neurological_phenoty0.84603675
83MP0001501_abnormal_sleep_pattern0.84235954
84MP0001905_abnormal_dopamine_level0.83354389
85MP0001764_abnormal_homeostasis0.82851613
86MP0009785_altered_susceptibility_to0.82096708
87MP0002234_abnormal_pharynx_morphology0.79616836
88MP0004043_abnormal_pH_regulation0.79251847
89MP0002067_abnormal_sensory_capabilities0.78708848
90MP0002734_abnormal_mechanical_nocicepti0.78397152
91MP0005636_abnormal_mineral_homeostasis0.78059112
92MP0002184_abnormal_innervation0.77282393
93MP0002733_abnormal_thermal_nociception0.75848246
94MP0002572_abnormal_emotion/affect_behav0.75603780
95MP0001324_abnormal_eye_pigmentation0.75596181
96MP0000538_abnormal_urinary_bladder0.74858304
97MP0003763_abnormal_thymus_physiology0.73789281
98MP0000647_abnormal_sebaceous_gland0.73652340
99MP0002752_abnormal_somatic_nervous0.73486185
100MP0005195_abnormal_posterior_eye0.70914944

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.81649549
2Increased CSF lactate (HP:0002490)3.57807495
3Hepatocellular necrosis (HP:0001404)3.53094830
4Acute encephalopathy (HP:0006846)3.52821055
5Abnormal mitochondria in muscle tissue (HP:0008316)3.49843146
6Mitochondrial inheritance (HP:0001427)3.49596461
7Pendular nystagmus (HP:0012043)3.42031030
8Progressive macrocephaly (HP:0004481)3.19888194
9Hepatic necrosis (HP:0002605)3.18519946
10Tubulointerstitial nephritis (HP:0001970)3.10091347
11Molar tooth sign on MRI (HP:0002419)3.06054514
12Abnormality of midbrain morphology (HP:0002418)3.06054514
13Generalized aminoaciduria (HP:0002909)2.91444500
14Hypoproteinemia (HP:0003075)2.84867938
15Increased serum lactate (HP:0002151)2.78468877
16IgG deficiency (HP:0004315)2.72660572
17Pancreatic cysts (HP:0001737)2.69387704
18Duplicated collecting system (HP:0000081)2.67230455
19Optic disc pallor (HP:0000543)2.66705305
20Abnormality of the renal collecting system (HP:0004742)2.65906057
21Medial flaring of the eyebrow (HP:0010747)2.65881232
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65555942
23Cerebral edema (HP:0002181)2.63252996
24Meckel diverticulum (HP:0002245)2.62775078
25Increased serum pyruvate (HP:0003542)2.60305294
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.55440561
27Abnormality of the ileum (HP:0001549)2.55331443
28Severe combined immunodeficiency (HP:0004430)2.49457206
29Congenital stationary night blindness (HP:0007642)2.47856978
30Thyroiditis (HP:0100646)2.45728953
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41897472
32Nephronophthisis (HP:0000090)2.40943781
33Absent thumb (HP:0009777)2.39043052
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38643127
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38643127
36Reticulocytopenia (HP:0001896)2.34462375
37Abnormality of the labia minora (HP:0012880)2.34007449
38Renal Fanconi syndrome (HP:0001994)2.32860617
39Chromsome breakage (HP:0040012)2.30923461
40Increased IgM level (HP:0003496)2.30448897
41Aplastic anemia (HP:0001915)2.29676317
42Pancytopenia (HP:0001876)2.29179879
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28991169
44Abnormality of alanine metabolism (HP:0010916)2.28991169
45Hyperalaninemia (HP:0003348)2.28991169
46Lactic acidosis (HP:0003128)2.27508465
473-Methylglutaconic aciduria (HP:0003535)2.27224754
48Nephrogenic diabetes insipidus (HP:0009806)2.25488976
49Abnormality of the preputium (HP:0100587)2.22197220
50Pancreatic fibrosis (HP:0100732)2.21833299
51Abnormality of glycolysis (HP:0004366)2.21697603
52Hyperglycinemia (HP:0002154)2.18784436
53Respiratory failure (HP:0002878)2.17075947
54Hypothermia (HP:0002045)2.16765229
55Abnormality of DNA repair (HP:0003254)2.15639477
56B lymphocytopenia (HP:0010976)2.15479152
57Abolished electroretinogram (ERG) (HP:0000550)2.15368218
58Abnormality of B cell number (HP:0010975)2.11952319
59Abnormality of chromosome stability (HP:0003220)2.11652995
60Gait imbalance (HP:0002141)2.09271024
61Increased hepatocellular lipid droplets (HP:0006565)2.08529880
62Abnormal rod and cone electroretinograms (HP:0008323)2.08088647
63Broad-based gait (HP:0002136)2.07867074
64Type I transferrin isoform profile (HP:0003642)2.07328306
65True hermaphroditism (HP:0010459)2.06204498
66Colon cancer (HP:0003003)2.05355925
67Clubbing of toes (HP:0100760)2.05208804
68Congenital primary aphakia (HP:0007707)2.04988985
69Attenuation of retinal blood vessels (HP:0007843)2.03054652
70Lipid accumulation in hepatocytes (HP:0006561)2.01282817
71Leukodystrophy (HP:0002415)1.99134884
72Abnormality of the renal medulla (HP:0100957)1.97629339
73Abnormality of eosinophils (HP:0001879)1.96935657
74Combined immunodeficiency (HP:0005387)1.96381449
75Stomatitis (HP:0010280)1.95879426
76Horizontal nystagmus (HP:0000666)1.95540075
77Ependymoma (HP:0002888)1.93276153
78Lissencephaly (HP:0001339)1.93142621
79Lethargy (HP:0001254)1.92294729
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91056542
81Abnormal protein glycosylation (HP:0012346)1.90982330
82Abnormal glycosylation (HP:0012345)1.90982330
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90982330
84Abnormal protein N-linked glycosylation (HP:0012347)1.90982330
85Chronic hepatic failure (HP:0100626)1.90603422
86Focal motor seizures (HP:0011153)1.89228974
87Abnormality of serum amino acid levels (HP:0003112)1.87886625
88Duodenal stenosis (HP:0100867)1.85403733
89Small intestinal stenosis (HP:0012848)1.85403733
90Abnormality of pyrimidine metabolism (HP:0004353)1.85063874
91X-linked dominant inheritance (HP:0001423)1.81116761
92Renal cortical cysts (HP:0000803)1.78627858
93Type 2 muscle fiber atrophy (HP:0003554)1.77875180
94CNS demyelination (HP:0007305)1.77265674
95Hypomagnesemia (HP:0002917)1.76710057
96Ectopic kidney (HP:0000086)1.75144158
97Progressive inability to walk (HP:0002505)1.74215833
98Abnormality of the renal cortex (HP:0011035)1.73922169
99Tubular atrophy (HP:0000092)1.73700757
100Sloping forehead (HP:0000340)1.71750589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.16589335
2WNK32.72899014
3MAP3K122.72576195
4FRK2.58553190
5ZAK2.42226560
6TESK22.39420095
7MARK12.24648452
8MAP4K22.18314280
9VRK22.17245193
10MST42.15957403
11EIF2AK32.10463714
12KDR1.92659088
13BUB11.90263379
14PLK21.84672924
15BCR1.79059112
16DYRK21.77836136
17ADRBK21.72842617
18PLK31.72549129
19BMPR1B1.71798360
20BCKDK1.70138205
21PDK21.64431808
22PLK41.61227430
23VRK11.60590152
24TAOK31.59474236
25NUAK11.55206683
26TSSK61.50023023
27ERBB31.49552579
28GRK11.47132552
29TXK1.46231004
30WNK41.44521556
31CASK1.39952865
32MKNK21.39680374
33MAPK131.38176593
34SRPK11.31644157
35TLK11.28436798
36CSNK1G31.20399653
37CSNK1G21.15359909
38NEK11.13371507
39CSNK1G11.10879120
40WEE11.09297661
41NME11.05955925
42STK391.05905678
43DAPK11.04297359
44MAP2K71.04180789
45LIMK11.01011357
46MKNK10.97861550
47CDK80.93921587
48CSNK1A1L0.93537942
49EIF2AK10.92297603
50PLK10.91965092
51TEC0.91757163
52MAP3K40.89174396
53MINK10.87413803
54ACVR1B0.83783109
55CDC70.83374382
56ITK0.82500592
57EIF2AK20.81972946
58OXSR10.80421442
59ATR0.78421770
60SIK30.71587821
61GRK50.70030813
62YES10.66984046
63INSRR0.62836496
64EPHA40.60618319
65PBK0.59786070
66IKBKB0.59418911
67PRKCG0.58996856
68DAPK20.58379490
69TAF10.56914131
70PAK30.56672878
71MAP4K10.56064978
72ADRBK10.55772443
73GRK60.53490270
74PRKCQ0.53282984
75TTK0.53236581
76PIK3CA0.49462335
77PRKCE0.47351836
78PIK3CG0.47050029
79CAMKK20.46819784
80OBSCN0.46790678
81ATM0.44462868
82PINK10.44121521
83MARK30.43930192
84STK160.43680922
85CAMK2A0.43600639
86TGFBR10.41858228
87TNIK0.40239039
88CCNB10.39715940
89CSNK1A10.38284614
90AURKB0.38260510
91MATK0.38254561
92CSNK2A10.37663185
93SYK0.37615161
94CSNK1D0.35604082
95CHEK20.35590726
96PRKCA0.35033473
97IGF1R0.34972691
98CSNK2A20.32940390
99PRKACA0.32681629
100MYLK0.32093774

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36277241
2Non-homologous end-joining_Homo sapiens_hsa034503.17888395
3Protein export_Homo sapiens_hsa030603.08020984
4Oxidative phosphorylation_Homo sapiens_hsa001902.92326412
5RNA polymerase_Homo sapiens_hsa030202.89362280
6Parkinsons disease_Homo sapiens_hsa050122.48758643
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41206459
8Mismatch repair_Homo sapiens_hsa034302.29494805
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29357994
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26834393
11Steroid biosynthesis_Homo sapiens_hsa001002.22961911
12Homologous recombination_Homo sapiens_hsa034402.13344091
13DNA replication_Homo sapiens_hsa030302.10516712
14Fanconi anemia pathway_Homo sapiens_hsa034602.00106778
15Primary immunodeficiency_Homo sapiens_hsa053401.99813757
16Fatty acid elongation_Homo sapiens_hsa000621.89781562
17Propanoate metabolism_Homo sapiens_hsa006401.83324000
18RNA degradation_Homo sapiens_hsa030181.77864680
19One carbon pool by folate_Homo sapiens_hsa006701.64819153
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63564156
21Huntingtons disease_Homo sapiens_hsa050161.56903922
22Pyrimidine metabolism_Homo sapiens_hsa002401.55979755
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52391404
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51737289
25Alzheimers disease_Homo sapiens_hsa050101.49124293
26Phototransduction_Homo sapiens_hsa047441.48133303
27Basal transcription factors_Homo sapiens_hsa030221.46159950
28Nucleotide excision repair_Homo sapiens_hsa034201.40433532
29Base excision repair_Homo sapiens_hsa034101.37221788
30Butanoate metabolism_Homo sapiens_hsa006501.35660730
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28834544
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19409949
33Purine metabolism_Homo sapiens_hsa002301.15014747
34RNA transport_Homo sapiens_hsa030131.10911602
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10038941
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08272362
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05001264
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02967573
39Ribosome_Homo sapiens_hsa030101.00838314
40Cardiac muscle contraction_Homo sapiens_hsa042600.99129917
41Spliceosome_Homo sapiens_hsa030400.97995478
42Nicotine addiction_Homo sapiens_hsa050330.97798663
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92540187
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91448435
45Peroxisome_Homo sapiens_hsa041460.91180991
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.89667600
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88793004
48Nitrogen metabolism_Homo sapiens_hsa009100.86842141
49Allograft rejection_Homo sapiens_hsa053300.84863245
50Autoimmune thyroid disease_Homo sapiens_hsa053200.82101031
51Linoleic acid metabolism_Homo sapiens_hsa005910.81791692
52Asthma_Homo sapiens_hsa053100.81691863
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80958371
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.80622555
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78845828
56Caffeine metabolism_Homo sapiens_hsa002320.73807854
57Ether lipid metabolism_Homo sapiens_hsa005650.72352427
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70172266
59Fatty acid metabolism_Homo sapiens_hsa012120.69677722
60Metabolic pathways_Homo sapiens_hsa011000.68784035
61Collecting duct acid secretion_Homo sapiens_hsa049660.68441705
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68329927
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68004181
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67330615
65Fat digestion and absorption_Homo sapiens_hsa049750.66207594
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65670604
67Pyruvate metabolism_Homo sapiens_hsa006200.65126318
68Chemical carcinogenesis_Homo sapiens_hsa052040.64011653
69Vitamin B6 metabolism_Homo sapiens_hsa007500.62729617
70Tryptophan metabolism_Homo sapiens_hsa003800.62395436
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.62345578
72Selenocompound metabolism_Homo sapiens_hsa004500.60926194
73Retinol metabolism_Homo sapiens_hsa008300.60553848
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.60523506
75Cell cycle_Homo sapiens_hsa041100.58882557
76Oocyte meiosis_Homo sapiens_hsa041140.58463560
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57970925
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56270924
79Taste transduction_Homo sapiens_hsa047420.56163508
80Glutathione metabolism_Homo sapiens_hsa004800.55684303
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55599909
82Folate biosynthesis_Homo sapiens_hsa007900.54648415
83Type I diabetes mellitus_Homo sapiens_hsa049400.52997577
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51790499
85Olfactory transduction_Homo sapiens_hsa047400.50824564
86Graft-versus-host disease_Homo sapiens_hsa053320.50146176
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48582370
88Fatty acid degradation_Homo sapiens_hsa000710.45722854
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.44725545
90beta-Alanine metabolism_Homo sapiens_hsa004100.42476902
91Antigen processing and presentation_Homo sapiens_hsa046120.42155608
92Hematopoietic cell lineage_Homo sapiens_hsa046400.41730832
93T cell receptor signaling pathway_Homo sapiens_hsa046600.41586110
94p53 signaling pathway_Homo sapiens_hsa041150.40680331
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35773538
96Morphine addiction_Homo sapiens_hsa050320.33404905
97Sulfur metabolism_Homo sapiens_hsa009200.30419428
98GABAergic synapse_Homo sapiens_hsa047270.28123802
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26604253
100Rheumatoid arthritis_Homo sapiens_hsa053230.26342478

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