

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 4.75082004 |
| 2 | proteasome assembly (GO:0043248) | 4.45017715 |
| 3 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.33094857 |
| 4 | cullin deneddylation (GO:0010388) | 4.11590727 |
| 5 | protein deneddylation (GO:0000338) | 3.97695016 |
| 6 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.92758668 |
| 7 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.85138537 |
| 8 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.85138537 |
| 9 | protein complex biogenesis (GO:0070271) | 3.66063341 |
| 10 | protein polyglutamylation (GO:0018095) | 3.65732220 |
| 11 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.58369562 |
| 12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.56341251 |
| 13 | protein neddylation (GO:0045116) | 3.54921887 |
| 14 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.54621004 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.53388223 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.49451613 |
| 17 | cytidine metabolic process (GO:0046087) | 3.48076998 |
| 18 | cytidine catabolic process (GO:0006216) | 3.48076998 |
| 19 | cytidine deamination (GO:0009972) | 3.48076998 |
| 20 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.43556262 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.43556262 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 3.43556262 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.42838378 |
| 24 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.42400306 |
| 25 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.42400306 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.41551762 |
| 27 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39468494 |
| 28 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.37207231 |
| 29 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.35518833 |
| 30 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.35518833 |
| 31 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.35518833 |
| 32 | response to pheromone (GO:0019236) | 3.35071179 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.31340159 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.31316277 |
| 35 | termination of RNA polymerase III transcription (GO:0006386) | 3.31316277 |
| 36 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.31228784 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.31228784 |
| 38 | ATP synthesis coupled proton transport (GO:0015986) | 3.28432924 |
| 39 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.28432924 |
| 40 | regulation of cilium movement (GO:0003352) | 3.28391978 |
| 41 | iron-sulfur cluster assembly (GO:0016226) | 3.27846124 |
| 42 | metallo-sulfur cluster assembly (GO:0031163) | 3.27846124 |
| 43 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.24552286 |
| 44 | rRNA modification (GO:0000154) | 3.22794962 |
| 45 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.22358625 |
| 46 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.21517139 |
| 47 | DNA damage response, detection of DNA damage (GO:0042769) | 3.21242671 |
| 48 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.18510676 |
| 49 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.18510676 |
| 50 | aldehyde catabolic process (GO:0046185) | 3.17510888 |
| 51 | nucleobase catabolic process (GO:0046113) | 3.16207386 |
| 52 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.15343357 |
| 53 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.15343357 |
| 54 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.09697937 |
| 55 | negative regulation of ligase activity (GO:0051352) | 3.08591695 |
| 56 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.08591695 |
| 57 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.08018270 |
| 58 | chromatin remodeling at centromere (GO:0031055) | 3.07888856 |
| 59 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.06406639 |
| 60 | respiratory chain complex IV assembly (GO:0008535) | 3.05816886 |
| 61 | CENP-A containing nucleosome assembly (GO:0034080) | 3.00724632 |
| 62 | replication fork processing (GO:0031297) | 3.00260695 |
| 63 | peptidyl-histidine modification (GO:0018202) | 2.94746216 |
| 64 | male meiosis I (GO:0007141) | 2.94415333 |
| 65 | histone exchange (GO:0043486) | 2.91335188 |
| 66 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.89322207 |
| 67 | synapsis (GO:0007129) | 2.87430137 |
| 68 | piRNA metabolic process (GO:0034587) | 2.87283486 |
| 69 | chaperone-mediated protein transport (GO:0072321) | 2.86545847 |
| 70 | mannosylation (GO:0097502) | 2.86474995 |
| 71 | cytochrome complex assembly (GO:0017004) | 2.82473201 |
| 72 | regulation of glutamate secretion (GO:0014048) | 2.79043451 |
| 73 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.78869625 |
| 74 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.78869625 |
| 75 | isotype switching (GO:0045190) | 2.78869625 |
| 76 | protein-cofactor linkage (GO:0018065) | 2.77829116 |
| 77 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76671826 |
| 78 | meiosis I (GO:0007127) | 2.75290959 |
| 79 | histone H2A acetylation (GO:0043968) | 2.74782720 |
| 80 | platelet dense granule organization (GO:0060155) | 2.74067255 |
| 81 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.72478172 |
| 82 | pseudouridine synthesis (GO:0001522) | 2.71887543 |
| 83 | electron transport chain (GO:0022900) | 2.69159942 |
| 84 | respiratory electron transport chain (GO:0022904) | 2.68622356 |
| 85 | DNA double-strand break processing (GO:0000729) | 2.63945507 |
| 86 | positive regulation of ligase activity (GO:0051351) | 2.62749159 |
| 87 | cilium morphogenesis (GO:0060271) | 2.61638002 |
| 88 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.61292227 |
| 89 | negative regulation of telomere maintenance (GO:0032205) | 2.57977173 |
| 90 | protein prenylation (GO:0018342) | 2.57770497 |
| 91 | prenylation (GO:0097354) | 2.57770497 |
| 92 | postreplication repair (GO:0006301) | 2.56375426 |
| 93 | tRNA processing (GO:0008033) | 2.56361887 |
| 94 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.56072938 |
| 95 | adenosine metabolic process (GO:0046085) | 2.55715574 |
| 96 | nucleobase biosynthetic process (GO:0046112) | 2.54564928 |
| 97 | presynaptic membrane assembly (GO:0097105) | 2.54419405 |
| 98 | rRNA methylation (GO:0031167) | 2.53102150 |
| 99 | GPI anchor metabolic process (GO:0006505) | 2.52526558 |
| 100 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.50353995 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.53978457 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.54585668 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.26634289 |
| 4 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.17029404 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.99410244 |
| 6 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.90345566 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.86305187 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.82321947 |
| 9 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.75639449 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.52852308 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.42558724 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.42149783 |
| 13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.34607445 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.33715670 |
| 15 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.33043877 |
| 16 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.27075837 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.26366654 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.12374892 |
| 19 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.11632957 |
| 20 | EWS_26573619_Chip-Seq_HEK293_Human | 2.09692123 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.09335201 |
| 22 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.99564459 |
| 23 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.97429652 |
| 24 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.94591924 |
| 25 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.93455410 |
| 26 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.93187975 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.90903565 |
| 28 | P300_19829295_ChIP-Seq_ESCs_Human | 1.83383977 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.83136346 |
| 30 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.75627327 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.75619737 |
| 32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.74226839 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.71812826 |
| 34 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.60663645 |
| 35 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.58547381 |
| 36 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.57078707 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.52358283 |
| 38 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.51897766 |
| 39 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.51052774 |
| 40 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.48005918 |
| 41 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.45463789 |
| 42 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.44043641 |
| 43 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.42743851 |
| 44 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.40397469 |
| 45 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.38822686 |
| 46 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.36417126 |
| 47 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.34723998 |
| 48 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.32525186 |
| 49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.32099840 |
| 50 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.29699763 |
| 51 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.29699763 |
| 52 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.27277122 |
| 53 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.27098367 |
| 54 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.26940001 |
| 55 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.24981199 |
| 56 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24195389 |
| 57 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.23156159 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.20006920 |
| 59 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.19366145 |
| 60 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.16606799 |
| 61 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.16606799 |
| 62 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.14997608 |
| 63 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.14925232 |
| 64 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.13873322 |
| 65 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.11307118 |
| 66 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.09793786 |
| 67 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.06882064 |
| 68 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06701187 |
| 69 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.06278113 |
| 70 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.04892560 |
| 71 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.04855695 |
| 72 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.03932784 |
| 73 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.03017029 |
| 74 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.02208686 |
| 75 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.00509980 |
| 76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00352175 |
| 77 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00352175 |
| 78 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.00189121 |
| 79 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97672109 |
| 80 | NCOR_22424771_ChIP-Seq_293T_Human | 0.97393994 |
| 81 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.96126888 |
| 82 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 0.95864072 |
| 83 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.95604477 |
| 84 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.94144193 |
| 85 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.93276057 |
| 86 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.92719674 |
| 87 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.91079325 |
| 88 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.90488374 |
| 89 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.90468049 |
| 90 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.90266131 |
| 91 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.90077267 |
| 92 | AR_20517297_ChIP-Seq_VCAP_Human | 0.89568888 |
| 93 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.89417957 |
| 94 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.89269143 |
| 95 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.88905787 |
| 96 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.88329994 |
| 97 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.88093141 |
| 98 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.87292480 |
| 99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.87240362 |
| 100 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.86912190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.37384755 |
| 2 | MP0004147_increased_porphyrin_level | 3.19071528 |
| 3 | MP0000372_irregular_coat_pigmentation | 3.06306644 |
| 4 | MP0008058_abnormal_DNA_repair | 3.02328859 |
| 5 | MP0002736_abnormal_nociception_after | 2.97196894 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.95881828 |
| 7 | MP0001968_abnormal_touch/_nociception | 2.65546614 |
| 8 | MP0005671_abnormal_response_to | 2.55704958 |
| 9 | MP0001529_abnormal_vocalization | 2.35623711 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.31661229 |
| 11 | MP0005551_abnormal_eye_electrophysiolog | 2.30293236 |
| 12 | MP0001984_abnormal_olfaction | 2.29673027 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.11772858 |
| 14 | MP0010094_abnormal_chromosome_stability | 2.11640511 |
| 15 | MP0008789_abnormal_olfactory_epithelium | 2.08335560 |
| 16 | MP0008872_abnormal_physiological_respon | 2.07184388 |
| 17 | MP0006276_abnormal_autonomic_nervous | 1.96624913 |
| 18 | MP0005360_urolithiasis | 1.95114565 |
| 19 | MP0005075_abnormal_melanosome_morpholog | 1.90067884 |
| 20 | MP0005253_abnormal_eye_physiology | 1.87413986 |
| 21 | MP0003718_maternal_effect | 1.78881545 |
| 22 | MP0003880_abnormal_central_pattern | 1.72221735 |
| 23 | MP0008057_abnormal_DNA_replication | 1.65798182 |
| 24 | MP0003693_abnormal_embryo_hatching | 1.64624173 |
| 25 | MP0006292_abnormal_olfactory_placode | 1.54437125 |
| 26 | MP0001986_abnormal_taste_sensitivity | 1.51280631 |
| 27 | MP0001485_abnormal_pinna_reflex | 1.50128991 |
| 28 | MP0006035_abnormal_mitochondrial_morpho | 1.47595403 |
| 29 | MP0002272_abnormal_nervous_system | 1.45655911 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.43114969 |
| 31 | MP0005499_abnormal_olfactory_system | 1.41396797 |
| 32 | MP0005394_taste/olfaction_phenotype | 1.41396797 |
| 33 | MP0004142_abnormal_muscle_tone | 1.37944708 |
| 34 | MP0005084_abnormal_gallbladder_morpholo | 1.37801334 |
| 35 | MP0003786_premature_aging | 1.35301853 |
| 36 | MP0001486_abnormal_startle_reflex | 1.35233320 |
| 37 | MP0001188_hyperpigmentation | 1.34285320 |
| 38 | MP0002938_white_spotting | 1.31068972 |
| 39 | MP0002751_abnormal_autonomic_nervous | 1.28779561 |
| 40 | MP0003787_abnormal_imprinting | 1.24046804 |
| 41 | MP0002095_abnormal_skin_pigmentation | 1.23860412 |
| 42 | MP0003011_delayed_dark_adaptation | 1.21616056 |
| 43 | MP0002638_abnormal_pupillary_reflex | 1.21543319 |
| 44 | MP0004742_abnormal_vestibular_system | 1.17294282 |
| 45 | MP0003136_yellow_coat_color | 1.16786214 |
| 46 | MP0009046_muscle_twitch | 1.15350563 |
| 47 | MP0004957_abnormal_blastocyst_morpholog | 1.14472836 |
| 48 | MP0003195_calcinosis | 1.13291891 |
| 49 | MP0009745_abnormal_behavioral_response | 1.12717306 |
| 50 | MP0009697_abnormal_copulation | 1.11580222 |
| 51 | MP0002210_abnormal_sex_determination | 1.11446684 |
| 52 | MP0001929_abnormal_gametogenesis | 1.10967026 |
| 53 | MP0005377_hearing/vestibular/ear_phenot | 1.10523930 |
| 54 | MP0003878_abnormal_ear_physiology | 1.10523930 |
| 55 | MP0005645_abnormal_hypothalamus_physiol | 1.09848739 |
| 56 | MP0003121_genomic_imprinting | 1.08114335 |
| 57 | MP0001119_abnormal_female_reproductive | 1.07924005 |
| 58 | MP0003567_abnormal_fetal_cardiomyocyte | 1.03532913 |
| 59 | MP0000427_abnormal_hair_cycle | 1.02435468 |
| 60 | MP0001835_abnormal_antigen_presentation | 0.99586290 |
| 61 | MP0002557_abnormal_social/conspecific_i | 0.98396981 |
| 62 | MP0001970_abnormal_pain_threshold | 0.98081593 |
| 63 | MP0005171_absent_coat_pigmentation | 0.95693828 |
| 64 | MP0003646_muscle_fatigue | 0.95450860 |
| 65 | MP0001919_abnormal_reproductive_system | 0.94774788 |
| 66 | MP0002163_abnormal_gland_morphology | 0.94749010 |
| 67 | MP0000653_abnormal_sex_gland | 0.93924852 |
| 68 | MP0003137_abnormal_impulse_conducting | 0.93816278 |
| 69 | MP0008875_abnormal_xenobiotic_pharmacok | 0.92592384 |
| 70 | MP0002735_abnormal_chemical_nociception | 0.92144910 |
| 71 | MP0005410_abnormal_fertilization | 0.91961466 |
| 72 | MP0003698_abnormal_male_reproductive | 0.90983315 |
| 73 | MP0008995_early_reproductive_senescence | 0.90969334 |
| 74 | MP0005389_reproductive_system_phenotype | 0.90761456 |
| 75 | MP0001145_abnormal_male_reproductive | 0.90363217 |
| 76 | MP0005379_endocrine/exocrine_gland_phen | 0.89584829 |
| 77 | MP0003111_abnormal_nucleus_morphology | 0.89213346 |
| 78 | MP0000015_abnormal_ear_pigmentation | 0.88357928 |
| 79 | MP0002837_dystrophic_cardiac_calcinosis | 0.86249070 |
| 80 | MP0003186_abnormal_redox_activity | 0.86013811 |
| 81 | MP0004924_abnormal_behavior | 0.84603675 |
| 82 | MP0005386_behavior/neurological_phenoty | 0.84603675 |
| 83 | MP0001501_abnormal_sleep_pattern | 0.84235954 |
| 84 | MP0001905_abnormal_dopamine_level | 0.83354389 |
| 85 | MP0001764_abnormal_homeostasis | 0.82851613 |
| 86 | MP0009785_altered_susceptibility_to | 0.82096708 |
| 87 | MP0002234_abnormal_pharynx_morphology | 0.79616836 |
| 88 | MP0004043_abnormal_pH_regulation | 0.79251847 |
| 89 | MP0002067_abnormal_sensory_capabilities | 0.78708848 |
| 90 | MP0002734_abnormal_mechanical_nocicepti | 0.78397152 |
| 91 | MP0005636_abnormal_mineral_homeostasis | 0.78059112 |
| 92 | MP0002184_abnormal_innervation | 0.77282393 |
| 93 | MP0002733_abnormal_thermal_nociception | 0.75848246 |
| 94 | MP0002572_abnormal_emotion/affect_behav | 0.75603780 |
| 95 | MP0001324_abnormal_eye_pigmentation | 0.75596181 |
| 96 | MP0000538_abnormal_urinary_bladder | 0.74858304 |
| 97 | MP0003763_abnormal_thymus_physiology | 0.73789281 |
| 98 | MP0000647_abnormal_sebaceous_gland | 0.73652340 |
| 99 | MP0002752_abnormal_somatic_nervous | 0.73486185 |
| 100 | MP0005195_abnormal_posterior_eye | 0.70914944 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.81649549 |
| 2 | Increased CSF lactate (HP:0002490) | 3.57807495 |
| 3 | Hepatocellular necrosis (HP:0001404) | 3.53094830 |
| 4 | Acute encephalopathy (HP:0006846) | 3.52821055 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.49843146 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.49596461 |
| 7 | Pendular nystagmus (HP:0012043) | 3.42031030 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.19888194 |
| 9 | Hepatic necrosis (HP:0002605) | 3.18519946 |
| 10 | Tubulointerstitial nephritis (HP:0001970) | 3.10091347 |
| 11 | Molar tooth sign on MRI (HP:0002419) | 3.06054514 |
| 12 | Abnormality of midbrain morphology (HP:0002418) | 3.06054514 |
| 13 | Generalized aminoaciduria (HP:0002909) | 2.91444500 |
| 14 | Hypoproteinemia (HP:0003075) | 2.84867938 |
| 15 | Increased serum lactate (HP:0002151) | 2.78468877 |
| 16 | IgG deficiency (HP:0004315) | 2.72660572 |
| 17 | Pancreatic cysts (HP:0001737) | 2.69387704 |
| 18 | Duplicated collecting system (HP:0000081) | 2.67230455 |
| 19 | Optic disc pallor (HP:0000543) | 2.66705305 |
| 20 | Abnormality of the renal collecting system (HP:0004742) | 2.65906057 |
| 21 | Medial flaring of the eyebrow (HP:0010747) | 2.65881232 |
| 22 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.65555942 |
| 23 | Cerebral edema (HP:0002181) | 2.63252996 |
| 24 | Meckel diverticulum (HP:0002245) | 2.62775078 |
| 25 | Increased serum pyruvate (HP:0003542) | 2.60305294 |
| 26 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.55440561 |
| 27 | Abnormality of the ileum (HP:0001549) | 2.55331443 |
| 28 | Severe combined immunodeficiency (HP:0004430) | 2.49457206 |
| 29 | Congenital stationary night blindness (HP:0007642) | 2.47856978 |
| 30 | Thyroiditis (HP:0100646) | 2.45728953 |
| 31 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.41897472 |
| 32 | Nephronophthisis (HP:0000090) | 2.40943781 |
| 33 | Absent thumb (HP:0009777) | 2.39043052 |
| 34 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.38643127 |
| 35 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.38643127 |
| 36 | Reticulocytopenia (HP:0001896) | 2.34462375 |
| 37 | Abnormality of the labia minora (HP:0012880) | 2.34007449 |
| 38 | Renal Fanconi syndrome (HP:0001994) | 2.32860617 |
| 39 | Chromsome breakage (HP:0040012) | 2.30923461 |
| 40 | Increased IgM level (HP:0003496) | 2.30448897 |
| 41 | Aplastic anemia (HP:0001915) | 2.29676317 |
| 42 | Pancytopenia (HP:0001876) | 2.29179879 |
| 43 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.28991169 |
| 44 | Abnormality of alanine metabolism (HP:0010916) | 2.28991169 |
| 45 | Hyperalaninemia (HP:0003348) | 2.28991169 |
| 46 | Lactic acidosis (HP:0003128) | 2.27508465 |
| 47 | 3-Methylglutaconic aciduria (HP:0003535) | 2.27224754 |
| 48 | Nephrogenic diabetes insipidus (HP:0009806) | 2.25488976 |
| 49 | Abnormality of the preputium (HP:0100587) | 2.22197220 |
| 50 | Pancreatic fibrosis (HP:0100732) | 2.21833299 |
| 51 | Abnormality of glycolysis (HP:0004366) | 2.21697603 |
| 52 | Hyperglycinemia (HP:0002154) | 2.18784436 |
| 53 | Respiratory failure (HP:0002878) | 2.17075947 |
| 54 | Hypothermia (HP:0002045) | 2.16765229 |
| 55 | Abnormality of DNA repair (HP:0003254) | 2.15639477 |
| 56 | B lymphocytopenia (HP:0010976) | 2.15479152 |
| 57 | Abolished electroretinogram (ERG) (HP:0000550) | 2.15368218 |
| 58 | Abnormality of B cell number (HP:0010975) | 2.11952319 |
| 59 | Abnormality of chromosome stability (HP:0003220) | 2.11652995 |
| 60 | Gait imbalance (HP:0002141) | 2.09271024 |
| 61 | Increased hepatocellular lipid droplets (HP:0006565) | 2.08529880 |
| 62 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.08088647 |
| 63 | Broad-based gait (HP:0002136) | 2.07867074 |
| 64 | Type I transferrin isoform profile (HP:0003642) | 2.07328306 |
| 65 | True hermaphroditism (HP:0010459) | 2.06204498 |
| 66 | Colon cancer (HP:0003003) | 2.05355925 |
| 67 | Clubbing of toes (HP:0100760) | 2.05208804 |
| 68 | Congenital primary aphakia (HP:0007707) | 2.04988985 |
| 69 | Attenuation of retinal blood vessels (HP:0007843) | 2.03054652 |
| 70 | Lipid accumulation in hepatocytes (HP:0006561) | 2.01282817 |
| 71 | Leukodystrophy (HP:0002415) | 1.99134884 |
| 72 | Abnormality of the renal medulla (HP:0100957) | 1.97629339 |
| 73 | Abnormality of eosinophils (HP:0001879) | 1.96935657 |
| 74 | Combined immunodeficiency (HP:0005387) | 1.96381449 |
| 75 | Stomatitis (HP:0010280) | 1.95879426 |
| 76 | Horizontal nystagmus (HP:0000666) | 1.95540075 |
| 77 | Ependymoma (HP:0002888) | 1.93276153 |
| 78 | Lissencephaly (HP:0001339) | 1.93142621 |
| 79 | Lethargy (HP:0001254) | 1.92294729 |
| 80 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.91056542 |
| 81 | Abnormal protein glycosylation (HP:0012346) | 1.90982330 |
| 82 | Abnormal glycosylation (HP:0012345) | 1.90982330 |
| 83 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.90982330 |
| 84 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.90982330 |
| 85 | Chronic hepatic failure (HP:0100626) | 1.90603422 |
| 86 | Focal motor seizures (HP:0011153) | 1.89228974 |
| 87 | Abnormality of serum amino acid levels (HP:0003112) | 1.87886625 |
| 88 | Duodenal stenosis (HP:0100867) | 1.85403733 |
| 89 | Small intestinal stenosis (HP:0012848) | 1.85403733 |
| 90 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.85063874 |
| 91 | X-linked dominant inheritance (HP:0001423) | 1.81116761 |
| 92 | Renal cortical cysts (HP:0000803) | 1.78627858 |
| 93 | Type 2 muscle fiber atrophy (HP:0003554) | 1.77875180 |
| 94 | CNS demyelination (HP:0007305) | 1.77265674 |
| 95 | Hypomagnesemia (HP:0002917) | 1.76710057 |
| 96 | Ectopic kidney (HP:0000086) | 1.75144158 |
| 97 | Progressive inability to walk (HP:0002505) | 1.74215833 |
| 98 | Abnormality of the renal cortex (HP:0011035) | 1.73922169 |
| 99 | Tubular atrophy (HP:0000092) | 1.73700757 |
| 100 | Sloping forehead (HP:0000340) | 1.71750589 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 3.16589335 |
| 2 | WNK3 | 2.72899014 |
| 3 | MAP3K12 | 2.72576195 |
| 4 | FRK | 2.58553190 |
| 5 | ZAK | 2.42226560 |
| 6 | TESK2 | 2.39420095 |
| 7 | MARK1 | 2.24648452 |
| 8 | MAP4K2 | 2.18314280 |
| 9 | VRK2 | 2.17245193 |
| 10 | MST4 | 2.15957403 |
| 11 | EIF2AK3 | 2.10463714 |
| 12 | KDR | 1.92659088 |
| 13 | BUB1 | 1.90263379 |
| 14 | PLK2 | 1.84672924 |
| 15 | BCR | 1.79059112 |
| 16 | DYRK2 | 1.77836136 |
| 17 | ADRBK2 | 1.72842617 |
| 18 | PLK3 | 1.72549129 |
| 19 | BMPR1B | 1.71798360 |
| 20 | BCKDK | 1.70138205 |
| 21 | PDK2 | 1.64431808 |
| 22 | PLK4 | 1.61227430 |
| 23 | VRK1 | 1.60590152 |
| 24 | TAOK3 | 1.59474236 |
| 25 | NUAK1 | 1.55206683 |
| 26 | TSSK6 | 1.50023023 |
| 27 | ERBB3 | 1.49552579 |
| 28 | GRK1 | 1.47132552 |
| 29 | TXK | 1.46231004 |
| 30 | WNK4 | 1.44521556 |
| 31 | CASK | 1.39952865 |
| 32 | MKNK2 | 1.39680374 |
| 33 | MAPK13 | 1.38176593 |
| 34 | SRPK1 | 1.31644157 |
| 35 | TLK1 | 1.28436798 |
| 36 | CSNK1G3 | 1.20399653 |
| 37 | CSNK1G2 | 1.15359909 |
| 38 | NEK1 | 1.13371507 |
| 39 | CSNK1G1 | 1.10879120 |
| 40 | WEE1 | 1.09297661 |
| 41 | NME1 | 1.05955925 |
| 42 | STK39 | 1.05905678 |
| 43 | DAPK1 | 1.04297359 |
| 44 | MAP2K7 | 1.04180789 |
| 45 | LIMK1 | 1.01011357 |
| 46 | MKNK1 | 0.97861550 |
| 47 | CDK8 | 0.93921587 |
| 48 | CSNK1A1L | 0.93537942 |
| 49 | EIF2AK1 | 0.92297603 |
| 50 | PLK1 | 0.91965092 |
| 51 | TEC | 0.91757163 |
| 52 | MAP3K4 | 0.89174396 |
| 53 | MINK1 | 0.87413803 |
| 54 | ACVR1B | 0.83783109 |
| 55 | CDC7 | 0.83374382 |
| 56 | ITK | 0.82500592 |
| 57 | EIF2AK2 | 0.81972946 |
| 58 | OXSR1 | 0.80421442 |
| 59 | ATR | 0.78421770 |
| 60 | SIK3 | 0.71587821 |
| 61 | GRK5 | 0.70030813 |
| 62 | YES1 | 0.66984046 |
| 63 | INSRR | 0.62836496 |
| 64 | EPHA4 | 0.60618319 |
| 65 | PBK | 0.59786070 |
| 66 | IKBKB | 0.59418911 |
| 67 | PRKCG | 0.58996856 |
| 68 | DAPK2 | 0.58379490 |
| 69 | TAF1 | 0.56914131 |
| 70 | PAK3 | 0.56672878 |
| 71 | MAP4K1 | 0.56064978 |
| 72 | ADRBK1 | 0.55772443 |
| 73 | GRK6 | 0.53490270 |
| 74 | PRKCQ | 0.53282984 |
| 75 | TTK | 0.53236581 |
| 76 | PIK3CA | 0.49462335 |
| 77 | PRKCE | 0.47351836 |
| 78 | PIK3CG | 0.47050029 |
| 79 | CAMKK2 | 0.46819784 |
| 80 | OBSCN | 0.46790678 |
| 81 | ATM | 0.44462868 |
| 82 | PINK1 | 0.44121521 |
| 83 | MARK3 | 0.43930192 |
| 84 | STK16 | 0.43680922 |
| 85 | CAMK2A | 0.43600639 |
| 86 | TGFBR1 | 0.41858228 |
| 87 | TNIK | 0.40239039 |
| 88 | CCNB1 | 0.39715940 |
| 89 | CSNK1A1 | 0.38284614 |
| 90 | AURKB | 0.38260510 |
| 91 | MATK | 0.38254561 |
| 92 | CSNK2A1 | 0.37663185 |
| 93 | SYK | 0.37615161 |
| 94 | CSNK1D | 0.35604082 |
| 95 | CHEK2 | 0.35590726 |
| 96 | PRKCA | 0.35033473 |
| 97 | IGF1R | 0.34972691 |
| 98 | CSNK2A2 | 0.32940390 |
| 99 | PRKACA | 0.32681629 |
| 100 | MYLK | 0.32093774 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.36277241 |
| 2 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.17888395 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.08020984 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.92326412 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.89362280 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.48758643 |
| 7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.41206459 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.29494805 |
| 9 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.29357994 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.26834393 |
| 11 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.22961911 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.13344091 |
| 13 | DNA replication_Homo sapiens_hsa03030 | 2.10516712 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.00106778 |
| 15 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.99813757 |
| 16 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.89781562 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.83324000 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.77864680 |
| 19 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.64819153 |
| 20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.63564156 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.56903922 |
| 22 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.55979755 |
| 23 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.52391404 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.51737289 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.49124293 |
| 26 | Phototransduction_Homo sapiens_hsa04744 | 1.48133303 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.46159950 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.40433532 |
| 29 | Base excision repair_Homo sapiens_hsa03410 | 1.37221788 |
| 30 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.35660730 |
| 31 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.28834544 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.19409949 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 1.15014747 |
| 34 | RNA transport_Homo sapiens_hsa03013 | 1.10911602 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.10038941 |
| 36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.08272362 |
| 37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.05001264 |
| 38 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.02967573 |
| 39 | Ribosome_Homo sapiens_hsa03010 | 1.00838314 |
| 40 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.99129917 |
| 41 | Spliceosome_Homo sapiens_hsa03040 | 0.97995478 |
| 42 | Nicotine addiction_Homo sapiens_hsa05033 | 0.97798663 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.92540187 |
| 44 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.91448435 |
| 45 | Peroxisome_Homo sapiens_hsa04146 | 0.91180991 |
| 46 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.89667600 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.88793004 |
| 48 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.86842141 |
| 49 | Allograft rejection_Homo sapiens_hsa05330 | 0.84863245 |
| 50 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.82101031 |
| 51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.81791692 |
| 52 | Asthma_Homo sapiens_hsa05310 | 0.81691863 |
| 53 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.80958371 |
| 54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.80622555 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.78845828 |
| 56 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.73807854 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.72352427 |
| 58 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.70172266 |
| 59 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.69677722 |
| 60 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68784035 |
| 61 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.68441705 |
| 62 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.68329927 |
| 63 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.68004181 |
| 64 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.67330615 |
| 65 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.66207594 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.65670604 |
| 67 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.65126318 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.64011653 |
| 69 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.62729617 |
| 70 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.62395436 |
| 71 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.62345578 |
| 72 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60926194 |
| 73 | Retinol metabolism_Homo sapiens_hsa00830 | 0.60553848 |
| 74 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.60523506 |
| 75 | Cell cycle_Homo sapiens_hsa04110 | 0.58882557 |
| 76 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58463560 |
| 77 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.57970925 |
| 78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.56270924 |
| 79 | Taste transduction_Homo sapiens_hsa04742 | 0.56163508 |
| 80 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.55684303 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.55599909 |
| 82 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.54648415 |
| 83 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.52997577 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.51790499 |
| 85 | Olfactory transduction_Homo sapiens_hsa04740 | 0.50824564 |
| 86 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.50146176 |
| 87 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.48582370 |
| 88 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.45722854 |
| 89 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44725545 |
| 90 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.42476902 |
| 91 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.42155608 |
| 92 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.41730832 |
| 93 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.41586110 |
| 94 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.40680331 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.35773538 |
| 96 | Morphine addiction_Homo sapiens_hsa05032 | 0.33404905 |
| 97 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.30419428 |
| 98 | GABAergic synapse_Homo sapiens_hsa04727 | 0.28123802 |
| 99 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.26604253 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.26342478 |

