ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA integration (GO:0015074)	5.29433755
2	response to pheromone (GO:0019236)	5.06643404
3	cell wall macromolecule catabolic process (GO:0016998)	4.58865989
4	regulation of female receptivity (GO:0045924)	4.44683314
5	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.31639680
6	histone H3-K4 trimethylation (GO:0080182)	4.29471242
7	protein K6-linked ubiquitination (GO:0085020)	4.27982016
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.20285001
9	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.09844770
10	microtubule severing (GO:0051013)	4.00170264
11	positive regulation of fatty acid oxidation (GO:0046321)	3.98336500
12	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.95360839
13	female mating behavior (GO:0060180)	3.93956689
14	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.89259717
15	meiotic chromosome segregation (GO:0045132)	3.85639524
16	cell wall macromolecule metabolic process (GO:0044036)	3.84160421
17	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.78075214
18	ketone body metabolic process (GO:1902224)	3.74846341
19	positive regulation of male gonad development (GO:2000020)	3.70376229
20	dopamine transport (GO:0015872)	3.68401406
21	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.68143960
22	pseudouridine synthesis (GO:0001522)	3.65852868
23	organelle disassembly (GO:1903008)	3.60555742
24	L-methionine salvage (GO:0071267)	3.57948278
25	L-methionine biosynthetic process (GO:0071265)	3.57948278
26	amino acid salvage (GO:0043102)	3.57948278
27	respiratory chain complex IV assembly (GO:0008535)	3.56289269
28	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.54874042
29	regulation of hexokinase activity (GO:1903299)	3.47840806
30	regulation of glucokinase activity (GO:0033131)	3.47840806
31	cellular ketone body metabolic process (GO:0046950)	3.43402576
32	regulation of cilium movement (GO:0003352)	3.39631573
33	purine deoxyribonucleotide catabolic process (GO:0009155)	3.38423946
34	ribonucleoprotein complex disassembly (GO:0032988)	3.30483225
35	piRNA metabolic process (GO:0034587)	3.28587922
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.26929326
37	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.26929326
38	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.13374274
39	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.13176901
40	regulation of male gonad development (GO:2000018)	3.12289529
41	purine deoxyribonucleotide metabolic process (GO:0009151)	3.07052024
42	coenzyme catabolic process (GO:0009109)	3.04559731
43	secondary metabolite biosynthetic process (GO:0044550)	3.04466460
44	indolalkylamine metabolic process (GO:0006586)	3.03493196
45	cytochrome complex assembly (GO:0017004)	3.02876202
46	indole-containing compound catabolic process (GO:0042436)	3.01318356
47	indolalkylamine catabolic process (GO:0046218)	3.01318356
48	tryptophan catabolic process (GO:0006569)	3.01318356
49	replication fork processing (GO:0031297)	3.00542057
50	rhodopsin mediated signaling pathway (GO:0016056)	2.99152019
51	methionine metabolic process (GO:0006555)	2.95619761
52	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.95525444
53	peptidyl-lysine trimethylation (GO:0018023)	2.92812312
54	melanin biosynthetic process (GO:0042438)	2.90886675
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.89038830
56	autophagic vacuole fusion (GO:0000046)	2.86547978
57	auditory receptor cell stereocilium organization (GO:0060088)	2.84923505
58	peptidyl-histidine modification (GO:0018202)	2.84477156
59	positive regulation of vasculogenesis (GO:2001214)	2.82050989
60	methionine biosynthetic process (GO:0009086)	2.80221652
61	deoxyribonucleotide catabolic process (GO:0009264)	2.79795115
62	male meiosis (GO:0007140)	2.78625882
63	dentate gyrus development (GO:0021542)	2.77139737
64	regulation of T cell receptor signaling pathway (GO:0050856)	2.76774035
65	resolution of meiotic recombination intermediates (GO:0000712)	2.75485934
66	short-chain fatty acid metabolic process (GO:0046459)	2.72209038
67	serine family amino acid catabolic process (GO:0009071)	2.71196563
68	S-adenosylmethionine metabolic process (GO:0046500)	2.70141013
69	negative regulation of dendrite morphogenesis (GO:0050774)	2.70115022
70	negative regulation of dendrite development (GO:2000171)	2.69985154
71	tRNA processing (GO:0008033)	2.69913155
72	male meiosis I (GO:0007141)	2.66424391
73	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.65772554
74	cilium or flagellum-dependent cell motility (GO:0001539)	2.65625600
75	tachykinin receptor signaling pathway (GO:0007217)	2.65112031
76	negative regulation of mast cell activation (GO:0033004)	2.63802632
77	glycine metabolic process (GO:0006544)	2.62503269
78	DNA methylation involved in gamete generation (GO:0043046)	2.61824695
79	relaxation of smooth muscle (GO:0044557)	2.61772453
80	ventricular system development (GO:0021591)	2.61426436
81	nucleotide transmembrane transport (GO:1901679)	2.60286405
82	behavioral response to nicotine (GO:0035095)	2.59966451
83	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.57699240
84	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.57699240
85	ncRNA catabolic process (GO:0034661)	2.56567588
86	negative regulation of interleukin-1 beta production (GO:0032691)	2.56223497
87	deoxyribose phosphate catabolic process (GO:0046386)	2.56032856
88	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.55032629
89	cellular biogenic amine catabolic process (GO:0042402)	2.52692526
90	amine catabolic process (GO:0009310)	2.52692526
91	interferon-gamma production (GO:0032609)	2.52487829
92	rRNA catabolic process (GO:0016075)	2.51675824
93	keratinocyte development (GO:0003334)	2.50953247
94	neural tube formation (GO:0001841)	2.50865780
95	proteasome assembly (GO:0043248)	2.50241027
96	tryptophan metabolic process (GO:0006568)	2.50002855
97	deoxyribose phosphate metabolic process (GO:0019692)	2.48272186
98	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.47354717
99	detection of light stimulus involved in sensory perception (GO:0050962)	2.46802641
100	detection of light stimulus involved in visual perception (GO:0050908)	2.46802641

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.64504614
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.52013477
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05513371
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89642713
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.70391799
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.61627377
7	VDR_22108803_ChIP-Seq_LS180_Human	2.53545747
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.40127492
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.33359216
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.33170492
11	FUS_26573619_Chip-Seq_HEK293_Human	2.29750498
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.29573837
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26008352
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25349340
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.20419728
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.17960395
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.11164023
18	P300_19829295_ChIP-Seq_ESCs_Human	2.00608275
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.97688155
20	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95265284
21	EWS_26573619_Chip-Seq_HEK293_Human	1.92344005
22	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.82919364
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.82125029
24	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.81041334
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.80669760
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78784101
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.77248397
28	NANOG_19829295_ChIP-Seq_ESCs_Human	1.74521433
29	SOX2_19829295_ChIP-Seq_ESCs_Human	1.74521433
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69852198
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.68296643
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.68296643
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61667717
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.60277463
35	GATA3_26560356_Chip-Seq_TH2_Human	1.57666033
36	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.55210224
37	STAT3_23295773_ChIP-Seq_U87_Human	1.51956542
38	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.50477225
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.49920611
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49611284
41	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48144154
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.46319210
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45692888
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44379028
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.41761005
46	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40006297
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38975923
48	TCF4_23295773_ChIP-Seq_U87_Human	1.37305946
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.36533343
50	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.36429505
51	AR_25329375_ChIP-Seq_VCAP_Human	1.35934282
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.34839386
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34373616
54	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.34263363
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.33965436
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.32839821
57	AR_20517297_ChIP-Seq_VCAP_Human	1.30330124
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.30222215
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.29390129
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28691094
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.27823889
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27414889
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27414889
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27243459
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25345121
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24257980
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23424409
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23121670
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23012826
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22851055
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21847408
72	HOXB7_26014856_ChIP-Seq_BT474_Human	1.21821691
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21296931
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20406780
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17027137
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17026769
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11560777
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11560777
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.11104730
80	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.10698587
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10441926
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10042221
83	NCOR_22424771_ChIP-Seq_293T_Human	1.09579252
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07929157
85	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07720240
86	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.06662886
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05738016
88	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.05066916
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04895392
90	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.04406225
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03618115
92	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01762573
93	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01290093
94	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.01168458
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00927960
96	EGR1_19032775_ChIP-ChIP_M12_Human	1.00118889
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99473292
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98986873
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98976526
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97480563

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.62036052
2	MP0000372_irregular_coat_pigmentation	5.16030921
3	MP0003787_abnormal_imprinting	4.26082096
4	MP0003646_muscle_fatigue	3.93542581
5	MP0005075_abnormal_melanosome_morpholog	2.56988083
6	MP0005551_abnormal_eye_electrophysiolog	2.47732953
7	MP0000015_abnormal_ear_pigmentation	2.40933622
8	MP0001968_abnormal_touch/_nociception	2.31236016
9	MP0005171_absent_coat_pigmentation	2.22752022
10	MP0003880_abnormal_central_pattern	2.14628792
11	MP0006072_abnormal_retinal_apoptosis	2.02989052
12	MP0002638_abnormal_pupillary_reflex	2.00640167
13	MP0008877_abnormal_DNA_methylation	1.99092592
14	MP0002736_abnormal_nociception_after	1.99045926
15	MP0000569_abnormal_digit_pigmentation	1.97676203
16	MP0002095_abnormal_skin_pigmentation	1.92483408
17	MP0004381_abnormal_hair_follicle	1.83825035
18	MP0009780_abnormal_chondrocyte_physiolo	1.83646581
19	MP0002090_abnormal_vision	1.81740759
20	MP0002163_abnormal_gland_morphology	1.81005800
21	MP0005174_abnormal_tail_pigmentation	1.78096868
22	MP0005253_abnormal_eye_physiology	1.76903417
23	MP0006276_abnormal_autonomic_nervous	1.74275507
24	MP0003121_genomic_imprinting	1.70812212
25	MP0001984_abnormal_olfaction	1.70160581
26	MP0005645_abnormal_hypothalamus_physiol	1.62096692
27	MP0003045_fibrosis	1.60390464
28	MP0006292_abnormal_olfactory_placode	1.58659699
29	MP0003806_abnormal_nucleotide_metabolis	1.56888985
30	MP0000371_diluted_coat_color	1.54028680
31	MP0001324_abnormal_eye_pigmentation	1.52739124
32	MP0000427_abnormal_hair_cycle	1.45592190
33	MP0006036_abnormal_mitochondrial_physio	1.44205987
34	MP0005408_hypopigmentation	1.38956344
35	MP0002234_abnormal_pharynx_morphology	1.38949010
36	MP0002909_abnormal_adrenal_gland	1.36788022
37	MP0002102_abnormal_ear_morphology	1.35209308
38	MP0000631_abnormal_neuroendocrine_gland	1.35043827
39	MP0003878_abnormal_ear_physiology	1.29479061
40	MP0005377_hearing/vestibular/ear_phenot	1.29479061
41	MP0005671_abnormal_response_to	1.25012105
42	MP0005670_abnormal_white_adipose	1.23366952
43	MP0004133_heterotaxia	1.23093083
44	MP0004043_abnormal_pH_regulation	1.22272568
45	MP0009333_abnormal_splenocyte_physiolog	1.21863790
46	MP0002938_white_spotting	1.20853720
47	MP0002653_abnormal_ependyma_morphology	1.18879546
48	MP0008872_abnormal_physiological_respon	1.15325148
49	MP0002168_other_aberrant_phenotype	1.14419281
50	MP0003195_calcinosis	1.14096785
51	MP0003567_abnormal_fetal_cardiomyocyte	1.12979568
52	MP0005646_abnormal_pituitary_gland	1.09934978
53	MP0005379_endocrine/exocrine_gland_phen	1.08916793
54	MP0001529_abnormal_vocalization	1.07871838
55	MP0010094_abnormal_chromosome_stability	1.06472481
56	MP0001851_eye_inflammation	1.02713709
57	MP0003122_maternal_imprinting	1.02178835
58	MP0009745_abnormal_behavioral_response	0.99238790
59	MP0003186_abnormal_redox_activity	0.97056832
60	MP0001905_abnormal_dopamine_level	0.96123364
61	MP0001485_abnormal_pinna_reflex	0.95932803
62	MP0005410_abnormal_fertilization	0.95903603
63	MP0004924_abnormal_behavior	0.94367761
64	MP0005386_behavior/neurological_phenoty	0.94367761
65	MP0004142_abnormal_muscle_tone	0.93971463
66	MP0008875_abnormal_xenobiotic_pharmacok	0.92570274
67	MP0008995_early_reproductive_senescence	0.91192565
68	MP0001919_abnormal_reproductive_system	0.90991459
69	MP0002210_abnormal_sex_determination	0.89717142
70	MP0001986_abnormal_taste_sensitivity	0.89485632
71	MP0000383_abnormal_hair_follicle	0.88892202
72	MP0003698_abnormal_male_reproductive	0.84656959
73	MP0001293_anophthalmia	0.83454894
74	MP0002132_abnormal_respiratory_system	0.83428382
75	MP0005195_abnormal_posterior_eye	0.81349888
76	MP0001929_abnormal_gametogenesis	0.80401724
77	MP0009046_muscle_twitch	0.79507895
78	MP0001764_abnormal_homeostasis	0.78834206
79	MP0005275_abnormal_skin_tensile	0.78329319
80	MP0009785_altered_susceptibility_to	0.77419617
81	MP0006035_abnormal_mitochondrial_morpho	0.76775336
82	MP0010329_abnormal_lipoprotein_level	0.75958186
83	MP0008961_abnormal_basal_metabolism	0.75553639
84	MP0009764_decreased_sensitivity_to	0.74849613
85	MP0005389_reproductive_system_phenotype	0.73027940
86	MP0004885_abnormal_endolymph	0.72516659
87	MP0002229_neurodegeneration	0.71920525
88	MP0005451_abnormal_body_composition	0.71236755
89	MP0005395_other_phenotype	0.67941258
90	MP0005332_abnormal_amino_acid	0.67528171
91	MP0000653_abnormal_sex_gland	0.67332884
92	MP0008775_abnormal_heart_ventricle	0.66531233
93	MP0005391_vision/eye_phenotype	0.66373188
94	MP0008789_abnormal_olfactory_epithelium	0.64360994
95	MP0001145_abnormal_male_reproductive	0.64062152
96	MP0002075_abnormal_coat/hair_pigmentati	0.62434895
97	MP0001800_abnormal_humoral_immune	0.62303567
98	MP0001486_abnormal_startle_reflex	0.61169093
99	MP0000026_abnormal_inner_ear	0.59915231
100	MP0003938_abnormal_ear_development	0.59321362

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.13268265
2	True hermaphroditism (HP:0010459)	4.18312023
3	Severe visual impairment (HP:0001141)	4.02207205
4	Hypoproteinemia (HP:0003075)	3.96467275
5	Hyperglycinemia (HP:0002154)	3.96436102
6	Abnormality of macular pigmentation (HP:0008002)	3.31349582
7	Renal Fanconi syndrome (HP:0001994)	3.28997454
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.26978608
9	Concave nail (HP:0001598)	3.02269699
10	Increased hepatocellular lipid droplets (HP:0006565)	2.97947999
11	Pancreatic fibrosis (HP:0100732)	2.96715181
12	Lipid accumulation in hepatocytes (HP:0006561)	2.93077910
13	Decreased central vision (HP:0007663)	2.91105240
14	Hip dysplasia (HP:0001385)	2.89005398
15	Respiratory difficulties (HP:0002880)	2.84195614
16	Tubular atrophy (HP:0000092)	2.83419113
17	Pancreatic cysts (HP:0001737)	2.79559905
18	Ocular albinism (HP:0001107)	2.73956289
19	Abnormality of the fovea (HP:0000493)	2.70689059
20	Neonatal respiratory distress (HP:0002643)	2.70018190
21	Autoimmune hemolytic anemia (HP:0001890)	2.64849688
22	Albinism (HP:0001022)	2.64840851
23	Iris hypopigmentation (HP:0007730)	2.62876381
24	Abnormality of midbrain morphology (HP:0002418)	2.56363083
25	Molar tooth sign on MRI (HP:0002419)	2.56363083
26	Methylmalonic acidemia (HP:0002912)	2.46325873
27	Male pseudohermaphroditism (HP:0000037)	2.44464733
28	Hyperglycinuria (HP:0003108)	2.41781765
29	Acute encephalopathy (HP:0006846)	2.41717860
30	Abnormality of B cell number (HP:0010975)	2.40537237
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38211178
32	Cerebellar dysplasia (HP:0007033)	2.36300959
33	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.35778590
34	Abnormality of renal resorption (HP:0011038)	2.31990367
35	3-Methylglutaconic aciduria (HP:0003535)	2.29173503
36	B lymphocytopenia (HP:0010976)	2.28355940
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25900727
38	Type II lissencephaly (HP:0007260)	2.23836120
39	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23451082
40	Increased CSF lactate (HP:0002490)	2.22269864
41	Methylmalonic aciduria (HP:0012120)	2.21217233
42	Abnormality of the parathyroid morphology (HP:0011766)	2.20289635
43	Abnormality of glycine metabolism (HP:0010895)	2.19822651
44	Abnormality of serine family amino acid metabolism (HP:0010894)	2.19822651
45	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.18712633
46	Hypoplasia of the fovea (HP:0007750)	2.18712633
47	Chronic hepatic failure (HP:0100626)	2.16751077
48	Horizontal nystagmus (HP:0000666)	2.14918981
49	Disproportionate short-trunk short stature (HP:0003521)	2.13736656
50	Generalized hypopigmentation (HP:0007513)	2.13110226
51	Hyperalaninemia (HP:0003348)	2.12229378
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12229378
53	Abnormality of alanine metabolism (HP:0010916)	2.12229378
54	Abnormal sex determination (HP:0012244)	2.09126907
55	Sex reversal (HP:0012245)	2.09126907
56	11 pairs of ribs (HP:0000878)	2.06475217
57	Abnormality of male internal genitalia (HP:0000022)	2.05412533
58	Acute necrotizing encephalopathy (HP:0006965)	2.05404239
59	Short chin (HP:0000331)	2.03860002
60	Delayed gross motor development (HP:0002194)	2.03574915
61	Thyroiditis (HP:0100646)	2.03485008
62	Hypoalbuminemia (HP:0003073)	2.01505498
63	Abnormal albumin level (HP:0012116)	2.01505498
64	Attenuation of retinal blood vessels (HP:0007843)	1.99794847
65	Increased intramyocellular lipid droplets (HP:0012240)	1.99658055
66	Mitochondrial inheritance (HP:0001427)	1.99604266
67	Cerebral hypomyelination (HP:0006808)	1.99567958
68	Abnormality of serum amino acid levels (HP:0003112)	1.98837243
69	IgG deficiency (HP:0004315)	1.98146881
70	Aplasia/Hypoplasia of the macula (HP:0008059)	1.95984317
71	Abnormality of endocrine pancreas physiology (HP:0012093)	1.95805037
72	Abnormality of the pancreatic islet cells (HP:0006476)	1.95805037
73	Pancreatic islet-cell hyperplasia (HP:0004510)	1.95432698
74	Acute hepatic failure (HP:0006554)	1.95044344
75	Abnormality of methionine metabolism (HP:0010901)	1.95032414
76	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94891707
77	Small hand (HP:0200055)	1.93851950
78	Hypoplastic iliac wings (HP:0002866)	1.92874455
79	Abnormality of the labia minora (HP:0012880)	1.92413934
80	Asplenia (HP:0001746)	1.92087801
81	Medial flaring of the eyebrow (HP:0010747)	1.90399925
82	Follicular hyperkeratosis (HP:0007502)	1.90372197
83	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.89137849
84	Mesangial abnormality (HP:0001966)	1.87174723
85	Polydipsia (HP:0001959)	1.86272428
86	Abnormal drinking behavior (HP:0030082)	1.86272428
87	Nephronophthisis (HP:0000090)	1.85795341
88	Abnormality of the fingertips (HP:0001211)	1.84327797
89	Abnormality of the renal cortex (HP:0011035)	1.84094778
90	Severe combined immunodeficiency (HP:0004430)	1.83962104
91	Hypothermia (HP:0002045)	1.83728671
92	Lethargy (HP:0001254)	1.79754754
93	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.77309441
94	Dicarboxylic aciduria (HP:0003215)	1.77309441
95	Increased serum lactate (HP:0002151)	1.76941067
96	Abolished electroretinogram (ERG) (HP:0000550)	1.76288105
97	Metaphyseal dysplasia (HP:0100255)	1.74666326
98	Lissencephaly (HP:0001339)	1.74545041
99	Progressive macrocephaly (HP:0004481)	1.73607737
100	Absent eyebrow (HP:0002223)	1.73321213

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	6.45158141
2	WNK3	4.77420426
3	MAP3K10	4.31084979
4	TRIM28	3.31048929
5	FRK	2.92768215
6	PINK1	2.67472198
7	BCKDK	2.52701659
8	TAOK3	2.28195268
9	TXK	2.09596567
10	CDC7	1.94148294
11	CDK19	1.88022490
12	KDR	1.79684335
13	ZAK	1.76594016
14	BMPR1B	1.74429020
15	GRK1	1.66116323
16	ADRBK2	1.45992910
17	MAPK13	1.37495368
18	BUB1	1.34027567
19	AKT3	1.32116422
20	NEK6	1.31370233
21	BCR	1.31071305
22	CLK1	1.27899037
23	ERBB3	1.20450937
24	ERBB2	1.19864392
25	PIM2	1.17669967
26	MKNK2	1.11421875
27	PBK	1.11213352
28	KIT	1.08044523
29	MAP3K4	1.07860921
30	WEE1	1.05346759
31	LRRK2	1.02494500
32	ABL2	0.99154983
33	CAMKK2	0.95692550
34	MKNK1	0.92585860
35	PAK3	0.89337659
36	PRKCH	0.88200131
37	OXSR1	0.85456156
38	CSNK1G1	0.84150786
39	MST4	0.83591179
40	DYRK2	0.83289777
41	NUAK1	0.82737427
42	PLK1	0.80036118
43	CSNK1G3	0.79581498
44	MAP2K7	0.77213327
45	PKN1	0.75517180
46	STK39	0.73142062
47	GRK6	0.72662037
48	JAK3	0.71104597
49	CSNK1G2	0.70141124
50	FLT3	0.69791574
51	ADRBK1	0.66022792
52	NTRK2	0.61954803
53	EIF2AK3	0.61351852
54	MARK1	0.60703156
55	PRKCE	0.60365539
56	PLK2	0.57931475
57	EGFR	0.57749797
58	MAP4K2	0.56495375
59	MAPK7	0.55041116
60	CSNK1A1	0.53603015
61	CCNB1	0.52910497
62	VRK1	0.52479723
63	MAPKAPK3	0.50638562
64	MINK1	0.49879783
65	IGF1R	0.49248733
66	ATR	0.48727861
67	STK10	0.48339453
68	PRKCQ	0.46936805
69	ACVR1B	0.45444143
70	DYRK3	0.45182066
71	PRKACA	0.44496497
72	TGFBR1	0.42823980
73	INSRR	0.42650865
74	NEK2	0.40684613
75	CAMK2A	0.40354607
76	AKT2	0.38830405
77	CSNK2A1	0.38662671
78	ATM	0.38482911
79	IKBKB	0.38351360
80	PRKCA	0.37898309
81	ITK	0.37557043
82	CSNK2A2	0.37516735
83	CAMK1	0.35828117
84	STK3	0.35518078
85	VRK2	0.34372468
86	PRKAA2	0.34172881
87	ABL1	0.33974287
88	PTK2B	0.33602091
89	MATK	0.33352547
90	PIK3CA	0.32847691
91	AKT1	0.32681942
92	TYK2	0.30773687
93	PRKACG	0.30333082
94	EIF2AK1	0.29802820
95	PLK3	0.29701746
96	PRKCI	0.29441757
97	DYRK1B	0.28611463
98	OBSCN	0.28232113
99	PRKCG	0.27950036
100	BRD4	0.26226879

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.84867257
2	Butanoate metabolism_Homo sapiens_hsa00650	2.88534167
3	Proteasome_Homo sapiens_hsa03050	2.67387663
4	Propanoate metabolism_Homo sapiens_hsa00640	2.55267429
5	Phototransduction_Homo sapiens_hsa04744	2.49794862
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.28216883
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18020639
8	Homologous recombination_Homo sapiens_hsa03440	2.11413036
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.08699719
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.05742084
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.03744925
12	Protein export_Homo sapiens_hsa03060	1.91820921
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.91638199
14	Parkinsons disease_Homo sapiens_hsa05012	1.88714691
15	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.82702404
16	Basal transcription factors_Homo sapiens_hsa03022	1.82618917
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.81737625
18	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.80439037
19	One carbon pool by folate_Homo sapiens_hsa00670	1.77905877
20	Peroxisome_Homo sapiens_hsa04146	1.70941736
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66737708
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.65313505
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.62642285
24	Mismatch repair_Homo sapiens_hsa03430	1.59578986
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48909739
26	ABC transporters_Homo sapiens_hsa02010	1.47474414
27	Regulation of autophagy_Homo sapiens_hsa04140	1.38030582
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.37616461
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.29370200
30	RNA degradation_Homo sapiens_hsa03018	1.23637198
31	Huntingtons disease_Homo sapiens_hsa05016	1.17982205
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.16913558
33	Purine metabolism_Homo sapiens_hsa00230	1.16618521
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16131172
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.10326899
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.06726038
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.03523276
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03441670
39	Olfactory transduction_Homo sapiens_hsa04740	1.02866708
40	Nicotine addiction_Homo sapiens_hsa05033	1.02865985
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.01941008
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00182040
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95780972
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.93909970
45	Nucleotide excision repair_Homo sapiens_hsa03420	0.93324881
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91673104
47	Tyrosine metabolism_Homo sapiens_hsa00350	0.91366891
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87245733
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86157673
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85873172
51	Asthma_Homo sapiens_hsa05310	0.84856084
52	Allograft rejection_Homo sapiens_hsa05330	0.84300970
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.83433229
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82047337
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81294614
56	RNA polymerase_Homo sapiens_hsa03020	0.79566191
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78649514
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76869995
59	Metabolic pathways_Homo sapiens_hsa01100	0.71201121
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70943162
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70534610
62	Fatty acid degradation_Homo sapiens_hsa00071	0.70381829
63	Alzheimers disease_Homo sapiens_hsa05010	0.69506302
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.68909358
65	Retinol metabolism_Homo sapiens_hsa00830	0.67837438
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67811252
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.67537468
68	Fatty acid elongation_Homo sapiens_hsa00062	0.66930973
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.66363473
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64639894
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63632840
72	Taste transduction_Homo sapiens_hsa04742	0.62312294
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61773493
74	Base excision repair_Homo sapiens_hsa03410	0.60954375
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56998696
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55255261
77	DNA replication_Homo sapiens_hsa03030	0.54894119
78	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52939449
79	Lysine degradation_Homo sapiens_hsa00310	0.52807609
80	Caffeine metabolism_Homo sapiens_hsa00232	0.52807001
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51966589
82	Morphine addiction_Homo sapiens_hsa05032	0.50036388
83	Spliceosome_Homo sapiens_hsa03040	0.49935132
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.47492401
85	Carbon metabolism_Homo sapiens_hsa01200	0.44809925
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43170435
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42590853
88	RNA transport_Homo sapiens_hsa03013	0.42544008
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41813792
90	GABAergic synapse_Homo sapiens_hsa04727	0.39807936
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38372892
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.37074901
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.36312641
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36169256
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.34068807
96	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33182004
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.32767181
98	Circadian rhythm_Homo sapiens_hsa04710	0.32289364
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31595153
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31273783

PPIAP20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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