PPIAP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.12848502
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.07418388
3ATP synthesis coupled proton transport (GO:0015986)5.42543278
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.42543278
5cytidine metabolic process (GO:0046087)5.38742715
6cytidine catabolic process (GO:0006216)5.38742715
7cytidine deamination (GO:0009972)5.38742715
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.19782333
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.82652556
10respiratory electron transport chain (GO:0022904)4.81000521
11Arp2/3 complex-mediated actin nucleation (GO:0034314)4.78401054
12electron transport chain (GO:0022900)4.72015363
13pyrimidine ribonucleoside catabolic process (GO:0046133)4.68376942
14sequestering of actin monomers (GO:0042989)4.40982044
15proteasome assembly (GO:0043248)4.26317636
16actin nucleation (GO:0045010)4.25831682
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.99139799
18protein neddylation (GO:0045116)3.98095550
19regulation of cellular amino acid metabolic process (GO:0006521)3.97945712
20platelet dense granule organization (GO:0060155)3.82772352
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77606675
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.76431999
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71880215
24negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.69590373
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68423100
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68423100
27establishment of protein localization to mitochondrial membrane (GO:0090151)3.68174000
28antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.65431780
29intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65265171
30signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65265171
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64332828
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64332828
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64332828
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56351986
35negative regulation of ligase activity (GO:0051352)3.56351986
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49767408
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42912901
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.42912901
39protein complex biogenesis (GO:0070271)3.41777374
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.41744094
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36425507
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33322256
43ribosomal small subunit assembly (GO:0000028)3.31495100
44hydrogen ion transmembrane transport (GO:1902600)3.24674482
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19866193
46deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17083479
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16544663
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13531412
49immunoglobulin mediated immune response (GO:0016064)3.12124290
50negative regulation of T cell apoptotic process (GO:0070233)3.10282984
51proton transport (GO:0015992)3.08740304
52purine deoxyribonucleotide catabolic process (GO:0009155)3.07275827
53hydrogen transport (GO:0006818)3.04050131
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.03942724
55NADH dehydrogenase complex assembly (GO:0010257)3.03942724
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03942724
57regulation of B cell receptor signaling pathway (GO:0050855)3.03866883
58mitochondrial respiratory chain complex assembly (GO:0033108)3.03723012
59cytolysis (GO:0019835)3.03436666
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.02794319
61positive regulation of interleukin-8 secretion (GO:2000484)3.02318987
62positive regulation of calcium-mediated signaling (GO:0050850)3.01854150
63ATP biosynthetic process (GO:0006754)2.99414254
64antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.98123300
65positive regulation of ligase activity (GO:0051351)2.97530823
66chaperone-mediated protein transport (GO:0072321)2.95572899
67respiratory chain complex IV assembly (GO:0008535)2.91138730
68oxidative phosphorylation (GO:0006119)2.86988966
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86684499
70cytochrome complex assembly (GO:0017004)2.85865916
71positive T cell selection (GO:0043368)2.85464591
72regulation of cellular amine metabolic process (GO:0033238)2.84425901
73regulation of interleukin-8 secretion (GO:2000482)2.84273473
74positive thymic T cell selection (GO:0045059)2.81802735
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.80696536
76response to interferon-beta (GO:0035456)2.79016966
77positive regulation of cell cycle arrest (GO:0071158)2.75270711
78mast cell activation (GO:0045576)2.74223787
79B cell mediated immunity (GO:0019724)2.73449147
80mannosylation (GO:0097502)2.73073578
81DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.72623317
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71233681
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70264364
84GPI anchor biosynthetic process (GO:0006506)2.68875465
85T cell migration (GO:0072678)2.68229139
86pyrimidine nucleoside catabolic process (GO:0046135)2.66772234
87iron-sulfur cluster assembly (GO:0016226)2.66684071
88metallo-sulfur cluster assembly (GO:0031163)2.66684071
89T cell costimulation (GO:0031295)2.66418983
90deoxyribose phosphate catabolic process (GO:0046386)2.66071636
91lymphocyte costimulation (GO:0031294)2.65722446
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.65264098
93termination of RNA polymerase III transcription (GO:0006386)2.65264098
94negative regulation of heart rate (GO:0010459)2.65157123
95positive regulation of B cell differentiation (GO:0045579)2.60567662
96deoxyribonucleotide catabolic process (GO:0009264)2.60372369
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59321068
98GPI anchor metabolic process (GO:0006505)2.58917299
99regulation of hypersensitivity (GO:0002883)2.58177242
100purine deoxyribonucleotide metabolic process (GO:0009151)2.57713699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.13245583
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.76262795
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73859371
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.44391007
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.19630587
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18456598
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84044250
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.76429235
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62184794
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60695450
11VDR_22108803_ChIP-Seq_LS180_Human2.55915888
12VDR_23849224_ChIP-Seq_CD4+_Human2.49120708
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42022672
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41094131
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37158281
16IGF1R_20145208_ChIP-Seq_DFB_Human2.36933434
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.25082641
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.17406980
19ELK1_19687146_ChIP-ChIP_HELA_Human2.13592697
20ZNF274_21170338_ChIP-Seq_K562_Hela2.10924704
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.98799034
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92129808
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91011745
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90621886
25FOXP3_21729870_ChIP-Seq_TREG_Human1.89852438
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79860360
27MYB_26560356_Chip-Seq_TH2_Human1.68010163
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67493705
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.67463841
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63483643
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57680866
32TAF15_26573619_Chip-Seq_HEK293_Human1.56926154
33GATA3_26560356_Chip-Seq_TH2_Human1.55718918
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53397511
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51518561
36TP53_22573176_ChIP-Seq_HFKS_Human1.49514322
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44423444
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42345166
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.42345166
40AR_20517297_ChIP-Seq_VCAP_Human1.39734135
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38822720
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37009978
43MYC_18940864_ChIP-ChIP_HL60_Human1.36595883
44HTT_18923047_ChIP-ChIP_STHdh_Human1.34780907
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33126873
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33014181
47EWS_26573619_Chip-Seq_HEK293_Human1.31625770
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31413643
49ERG_20517297_ChIP-Seq_VCAP_Human1.31246110
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30104859
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28061947
52SOX2_19829295_ChIP-Seq_ESCs_Human1.27646145
53NANOG_19829295_ChIP-Seq_ESCs_Human1.27646145
54P300_19829295_ChIP-Seq_ESCs_Human1.26585803
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25112760
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24384817
57ER_23166858_ChIP-Seq_MCF-7_Human1.24280617
58GATA3_27048872_Chip-Seq_THYMUS_Human1.23097772
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22469225
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22040792
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.20473049
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19932004
63FUS_26573619_Chip-Seq_HEK293_Human1.19132217
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18178002
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17921050
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14837155
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13659986
68CBP_20019798_ChIP-Seq_JUKART_Human1.13659986
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13330141
70EZH2_22144423_ChIP-Seq_EOC_Human1.12358646
71SPI1_23547873_ChIP-Seq_NB4_Human1.12185266
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10835660
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10797035
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10532437
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.09698600
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.08476767
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07506954
78NCOR_22424771_ChIP-Seq_293T_Human1.07108253
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05055213
80BCAT_22108803_ChIP-Seq_LS180_Human1.04795010
81CIITA_25753668_ChIP-Seq_RAJI_Human1.04410697
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.04208942
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.03361567
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.03246755
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02979477
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02223944
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01816954
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00443781
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.99120986
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99061590
91TAF2_19829295_ChIP-Seq_ESCs_Human0.98241930
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97927364
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96942191
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96597598
95MYC_19829295_ChIP-Seq_ESCs_Human0.96487609
96NANOG_20526341_ChIP-Seq_ESCs_Human0.95977536
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95207131
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95150477
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93916360
100MYB_26560356_Chip-Seq_TH1_Human0.93731229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.85647792
2MP0001835_abnormal_antigen_presentation3.83943808
3MP0009785_altered_susceptibility_to3.01117163
4MP0004147_increased_porphyrin_level2.58475740
5MP0002166_altered_tumor_susceptibility2.28975275
6MP0003806_abnormal_nucleotide_metabolis2.21043052
7MP0002102_abnormal_ear_morphology2.14663828
8MP0001800_abnormal_humoral_immune2.11393208
9MP0006072_abnormal_retinal_apoptosis2.10372849
10MP0002837_dystrophic_cardiac_calcinosis2.07896404
11MP0006292_abnormal_olfactory_placode2.04324357
12MP0000372_irregular_coat_pigmentation2.03090601
13MP0002148_abnormal_hypersensitivity_rea1.96809503
14MP0005645_abnormal_hypothalamus_physiol1.94553075
15MP0005000_abnormal_immune_tolerance1.93334099
16MP0006082_CNS_inflammation1.75529431
17MP0008872_abnormal_physiological_respon1.74043915
18MP0002006_tumorigenesis1.73164880
19MP0009333_abnormal_splenocyte_physiolog1.73051094
20MP0002723_abnormal_immune_serum1.72412967
21MP0005075_abnormal_melanosome_morpholog1.71049645
22MP0005025_abnormal_response_to1.70815314
23MP0002420_abnormal_adaptive_immunity1.70032590
24MP0001819_abnormal_immune_cell1.66822717
25MP0005084_abnormal_gallbladder_morpholo1.65489718
26MP0002452_abnormal_antigen_presenting1.63361095
27MP0005387_immune_system_phenotype1.62556815
28MP0001790_abnormal_immune_system1.62556815
29MP0003763_abnormal_thymus_physiology1.60584448
30MP0001905_abnormal_dopamine_level1.57615021
31MP0009379_abnormal_foot_pigmentation1.56210966
32MP0009764_decreased_sensitivity_to1.54703168
33MP0003646_muscle_fatigue1.54267460
34MP0006036_abnormal_mitochondrial_physio1.53031861
35MP0000685_abnormal_immune_system1.42898147
36MP0003866_abnormal_defecation1.42607795
37MP0008877_abnormal_DNA_methylation1.42500446
38MP0003880_abnormal_central_pattern1.41706274
39MP0003786_premature_aging1.41539446
40MP0001529_abnormal_vocalization1.40713667
41MP0005551_abnormal_eye_electrophysiolog1.38387530
42MP0003724_increased_susceptibility_to1.38230813
43MP0005646_abnormal_pituitary_gland1.36501978
44MP0003195_calcinosis1.32603614
45MP0008995_early_reproductive_senescence1.31745723
46MP0004145_abnormal_muscle_electrophysio1.31599075
47MP0008875_abnormal_xenobiotic_pharmacok1.30938970
48MP0005253_abnormal_eye_physiology1.30604645
49MP0000516_abnormal_urinary_system1.30345868
50MP0005367_renal/urinary_system_phenotyp1.30345868
51MP0008789_abnormal_olfactory_epithelium1.29069333
52MP0000716_abnormal_immune_system1.28783683
53MP0006276_abnormal_autonomic_nervous1.27096699
54MP0002638_abnormal_pupillary_reflex1.22788428
55MP0002736_abnormal_nociception_after1.21918709
56MP0003137_abnormal_impulse_conducting1.20681156
57MP0002398_abnormal_bone_marrow1.18689655
58MP0010155_abnormal_intestine_physiology1.14816120
59MP0004142_abnormal_muscle_tone1.14356906
60MP0001919_abnormal_reproductive_system1.12952841
61MP0001845_abnormal_inflammatory_respons1.11503714
62MP0001873_stomach_inflammation1.09925338
63MP0001968_abnormal_touch/_nociception1.07304734
64MP0009697_abnormal_copulation1.07290687
65MP0005389_reproductive_system_phenotype1.07242596
66MP0005410_abnormal_fertilization1.06761187
67MP0001764_abnormal_homeostasis1.04218854
68MP0002419_abnormal_innate_immunity1.04091600
69MP0003252_abnormal_bile_duct1.00679205
70MP0000689_abnormal_spleen_morphology1.00561696
71MP0005636_abnormal_mineral_homeostasis0.99902940
72MP0003787_abnormal_imprinting0.98851452
73MP0002138_abnormal_hepatobiliary_system0.98492898
74MP0003011_delayed_dark_adaptation0.97176704
75MP0008469_abnormal_protein_level0.96645340
76MP0001485_abnormal_pinna_reflex0.93034130
77MP0002429_abnormal_blood_cell0.92736384
78MP0003878_abnormal_ear_physiology0.91947621
79MP0005377_hearing/vestibular/ear_phenot0.91947621
80MP0002876_abnormal_thyroid_physiology0.90602588
81MP0002160_abnormal_reproductive_system0.87786963
82MP0009763_increased_sensitivity_to0.86806430
83MP0001501_abnormal_sleep_pattern0.86609784
84MP0002722_abnormal_immune_system0.85984405
85MP0002405_respiratory_system_inflammati0.85020817
86MP0001486_abnormal_startle_reflex0.84989561
87MP0005085_abnormal_gallbladder_physiolo0.84909573
88MP0010386_abnormal_urinary_bladder0.84679334
89MP0006035_abnormal_mitochondrial_morpho0.82933028
90MP0001986_abnormal_taste_sensitivity0.81332470
91MP0002234_abnormal_pharynx_morphology0.79518148
92MP0006054_spinal_hemorrhage0.78957688
93MP0009046_muscle_twitch0.77884954
94MP0005166_decreased_susceptibility_to0.77481148
95MP0005670_abnormal_white_adipose0.77133095
96MP0002933_joint_inflammation0.75927046
97MP0003186_abnormal_redox_activity0.74713990
98MP0002272_abnormal_nervous_system0.74497489
99MP0002095_abnormal_skin_pigmentation0.72299054
100MP0001765_abnormal_ion_homeostasis0.70101700

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.93851185
2Acute necrotizing encephalopathy (HP:0006965)4.84691191
3Mitochondrial inheritance (HP:0001427)4.76603450
4Hepatocellular necrosis (HP:0001404)4.47375109
5Abnormal mitochondria in muscle tissue (HP:0008316)4.36302918
6Progressive macrocephaly (HP:0004481)4.09608969
7Increased CSF lactate (HP:0002490)4.08470709
8Acute encephalopathy (HP:0006846)4.07602108
9Hypoproteinemia (HP:0003075)3.99095463
10Hepatic necrosis (HP:0002605)3.98167775
11Increased hepatocellular lipid droplets (HP:0006565)3.60554395
123-Methylglutaconic aciduria (HP:0003535)3.60411900
13IgG deficiency (HP:0004315)3.56625586
14Severe combined immunodeficiency (HP:0004430)3.42408838
15Elevated erythrocyte sedimentation rate (HP:0003565)3.38372323
16Cerebral edema (HP:0002181)3.33652164
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.28506639
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.28506639
19Abnormality of B cell number (HP:0010975)3.25009759
20Lipid accumulation in hepatocytes (HP:0006561)3.21673373
21Increased intramyocellular lipid droplets (HP:0012240)3.07502951
22Renal Fanconi syndrome (HP:0001994)3.05837897
23Abnormality of T cell number (HP:0011839)3.04793396
24T lymphocytopenia (HP:0005403)3.01276504
25Increased IgM level (HP:0003496)2.93320600
26Congenital, generalized hypertrichosis (HP:0004540)2.90179255
27B lymphocytopenia (HP:0010976)2.86440938
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83450764
29Exertional dyspnea (HP:0002875)2.76198312
30Thyroiditis (HP:0100646)2.75361213
31Abnormality of the prostate (HP:0008775)2.66268028
32Abolished electroretinogram (ERG) (HP:0000550)2.64981300
33Amyotrophic lateral sclerosis (HP:0007354)2.63286739
34Optic disc pallor (HP:0000543)2.62813221
35Combined immunodeficiency (HP:0005387)2.61290101
36Type I transferrin isoform profile (HP:0003642)2.60935780
37Lactic acidosis (HP:0003128)2.60092111
38Increased serum lactate (HP:0002151)2.53036007
39Autoimmune hemolytic anemia (HP:0001890)2.51695805
40Pancreatic cysts (HP:0001737)2.50598404
41Increased muscle lipid content (HP:0009058)2.50004562
42Methylmalonic acidemia (HP:0002912)2.47565473
43Congenital stationary night blindness (HP:0007642)2.46375675
44Respiratory failure (HP:0002878)2.46328498
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43584692
46Abnormality of eosinophils (HP:0001879)2.43082672
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41398949
48Attenuation of retinal blood vessels (HP:0007843)2.34729348
49Eosinophilia (HP:0001880)2.32379957
50True hermaphroditism (HP:0010459)2.30763583
51Decreased central vision (HP:0007663)2.29741074
52Pancytopenia (HP:0001876)2.29172073
53Abnormality of T cells (HP:0002843)2.24462518
54Leukodystrophy (HP:0002415)2.22907235
55Generalized aminoaciduria (HP:0002909)2.21999751
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21525115
57Chronic diarrhea (HP:0002028)2.20540750
58Type 2 muscle fiber atrophy (HP:0003554)2.18295726
59Lethargy (HP:0001254)2.17764060
60Abnormal rod and cone electroretinograms (HP:0008323)2.14729265
61Hypothermia (HP:0002045)2.12640474
62Abnormality of midbrain morphology (HP:0002418)2.12480929
63Molar tooth sign on MRI (HP:0002419)2.12480929
64Methylmalonic aciduria (HP:0012120)2.05067136
65Exercise intolerance (HP:0003546)2.04815634
66CNS demyelination (HP:0007305)2.03609092
67Panhypogammaglobulinemia (HP:0003139)2.02093217
68Pancreatic fibrosis (HP:0100732)1.99104605
69Constricted visual fields (HP:0001133)1.98195763
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95320974
71Abnormal protein N-linked glycosylation (HP:0012347)1.95320974
72Abnormal protein glycosylation (HP:0012346)1.95320974
73Abnormal glycosylation (HP:0012345)1.95320974
74Cerebral palsy (HP:0100021)1.91652461
75Glycosuria (HP:0003076)1.90096305
76Abnormality of urine glucose concentration (HP:0011016)1.90096305
77Dicarboxylic aciduria (HP:0003215)1.89018934
78Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89018934
79Encephalitis (HP:0002383)1.88679153
80Abnormality of renal resorption (HP:0011038)1.86637494
81Agammaglobulinemia (HP:0004432)1.86478624
82Abnormality of placental membranes (HP:0011409)1.82874920
83Amniotic constriction ring (HP:0009775)1.82874920
84Reduced antithrombin III activity (HP:0001976)1.79851903
85Oral leukoplakia (HP:0002745)1.79617496
86IgM deficiency (HP:0002850)1.79082092
87Granulocytopenia (HP:0001913)1.79046541
88Meningitis (HP:0001287)1.78445613
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.76896477
90Medial flaring of the eyebrow (HP:0010747)1.76312288
91Autoimmune thrombocytopenia (HP:0001973)1.76101299
92Muscle fiber atrophy (HP:0100295)1.75958948
93Abnormal albumin level (HP:0012116)1.73661530
94Hypoalbuminemia (HP:0003073)1.73661530
95Emotional lability (HP:0000712)1.72849682
96Chronic sinusitis (HP:0011109)1.72821075
97Hyperglycinemia (HP:0002154)1.72562431
98Acute hepatic failure (HP:0006554)1.71698252
99Parakeratosis (HP:0001036)1.71439748
100Hypoplasia of the thymus (HP:0000778)1.71172561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.48930538
2MAP3K123.45247660
3TESK23.29725384
4TXK3.00105122
5VRK22.54507561
6BCKDK2.50211217
7CDK192.44822458
8MAP4K22.43805663
9SCYL22.22650825
10ZAK2.22177401
11BMPR22.13284689
12TLK12.09512578
13TAOK31.97981237
14LIMK11.90076844
15TESK11.84921072
16MYLK1.82680377
17ADRBK21.79836678
18MAP4K11.79509132
19VRK11.60874510
20ERBB31.53169012
21GRK11.51806876
22TEC1.48616288
23ITK1.46899281
24STK161.34958617
25BUB11.33419326
26MST41.32766738
27CSNK1G31.31512260
28BCR1.28054080
29FRK1.24678838
30SYK1.24532241
31NUAK11.23775283
32TRIM281.23241748
33MUSK1.22658765
34PINK11.21912264
35MAPK131.16292216
36SRPK11.15420729
37WNK31.13448932
38DAPK11.12770521
39OXSR11.12740174
40GRK61.09045845
41CSF1R1.06827976
42MAP2K71.04507977
43CSNK1A1L1.02246441
44INSRR0.99711494
45EIF2AK30.99592262
46LYN0.98321577
47BTK0.96996718
48CSNK1G10.96736841
49PIK3CG0.96628482
50CSNK1G20.96548835
51GRK70.92894264
52KIT0.85143023
53RPS6KA40.84458221
54TIE10.80572682
55LCK0.76352469
56MAP3K40.75628567
57RPS6KA50.75624776
58ILK0.74009409
59TNK20.73250886
60PIM20.69157895
61FES0.67037404
62NME10.64876699
63PLK40.64634752
64OBSCN0.64449741
65PASK0.62269820
66IKBKB0.61219293
67DYRK20.59433596
68DAPK30.59186657
69NEK10.58317412
70PRKCQ0.57661166
71ZAP700.57623370
72MATK0.56956706
73FLT30.56124203
74PLK20.55930357
75ROCK10.52154081
76MAP3K50.52116596
77BMPR1B0.50275408
78IGF1R0.49325425
79CCNB10.48388271
80WNK40.47431212
81PRKCE0.46703711
82ADRBK10.45623385
83IKBKE0.44792934
84PTK2B0.44762209
85CSNK2A10.44104224
86MAP3K110.43121659
87PAK40.42150587
88STK38L0.42112110
89CDK80.42082038
90RIPK40.40838531
91BLK0.39009243
92PRKACA0.38808051
93ABL10.38502231
94PKN10.37444439
95PRKCA0.36718991
96AURKB0.36218080
97EGFR0.34933837
98CSNK2A20.34183772
99CAMK2A0.34120929
100PIM10.33651547

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.63155442
2Oxidative phosphorylation_Homo sapiens_hsa001904.00467284
3Asthma_Homo sapiens_hsa053103.51263324
4Parkinsons disease_Homo sapiens_hsa050123.37233345
5Allograft rejection_Homo sapiens_hsa053303.19180063
6Graft-versus-host disease_Homo sapiens_hsa053323.16396654
7Autoimmune thyroid disease_Homo sapiens_hsa053203.13236076
8Primary immunodeficiency_Homo sapiens_hsa053403.05209771
9Type I diabetes mellitus_Homo sapiens_hsa049402.70774908
10Protein export_Homo sapiens_hsa030602.67749005
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.43903200
12Antigen processing and presentation_Homo sapiens_hsa046122.37450193
13Ribosome_Homo sapiens_hsa030102.33774333
14Alzheimers disease_Homo sapiens_hsa050102.25497923
15Huntingtons disease_Homo sapiens_hsa050162.05187396
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93856459
17RNA polymerase_Homo sapiens_hsa030201.87954233
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65980563
19Rheumatoid arthritis_Homo sapiens_hsa053231.63653248
20Cardiac muscle contraction_Homo sapiens_hsa042601.63006570
21Hematopoietic cell lineage_Homo sapiens_hsa046401.62521575
22Viral myocarditis_Homo sapiens_hsa054161.55084243
23Homologous recombination_Homo sapiens_hsa034401.46587548
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44237291
25Phototransduction_Homo sapiens_hsa047441.32693775
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29499038
27Staphylococcus aureus infection_Homo sapiens_hsa051501.16879969
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12522656
29DNA replication_Homo sapiens_hsa030301.00825106
30Mismatch repair_Homo sapiens_hsa034300.99448806
31RNA degradation_Homo sapiens_hsa030180.97778065
32Systemic lupus erythematosus_Homo sapiens_hsa053220.96906156
33Pyrimidine metabolism_Homo sapiens_hsa002400.95498658
34Propanoate metabolism_Homo sapiens_hsa006400.92980751
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92794555
36Spliceosome_Homo sapiens_hsa030400.90592382
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86784478
38Fanconi anemia pathway_Homo sapiens_hsa034600.81314940
39Nitrogen metabolism_Homo sapiens_hsa009100.77802535
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77267897
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74910858
42Linoleic acid metabolism_Homo sapiens_hsa005910.74615873
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74482870
44Leishmaniasis_Homo sapiens_hsa051400.73111330
45Caffeine metabolism_Homo sapiens_hsa002320.72560134
46Peroxisome_Homo sapiens_hsa041460.70832727
47Collecting duct acid secretion_Homo sapiens_hsa049660.70637320
48Purine metabolism_Homo sapiens_hsa002300.69710626
49Nucleotide excision repair_Homo sapiens_hsa034200.69566217
50Base excision repair_Homo sapiens_hsa034100.68651416
51Olfactory transduction_Homo sapiens_hsa047400.68301846
52Chemical carcinogenesis_Homo sapiens_hsa052040.65695724
53Butanoate metabolism_Homo sapiens_hsa006500.63587546
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62760204
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62163549
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.60503670
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60457302
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60400577
59One carbon pool by folate_Homo sapiens_hsa006700.56856996
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54124258
61Tryptophan metabolism_Homo sapiens_hsa003800.53852531
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53644287
63T cell receptor signaling pathway_Homo sapiens_hsa046600.53115969
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52096272
65Salmonella infection_Homo sapiens_hsa051320.52051659
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50059066
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49084260
68Herpes simplex infection_Homo sapiens_hsa051680.48814745
69Regulation of autophagy_Homo sapiens_hsa041400.48256715
70Basal transcription factors_Homo sapiens_hsa030220.47718122
71Retinol metabolism_Homo sapiens_hsa008300.47631677
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.47569384
73Shigellosis_Homo sapiens_hsa051310.47352519
74Metabolic pathways_Homo sapiens_hsa011000.46642877
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.45872232
76Taste transduction_Homo sapiens_hsa047420.44420175
77Non-homologous end-joining_Homo sapiens_hsa034500.43994473
78RNA transport_Homo sapiens_hsa030130.43919981
79Epstein-Barr virus infection_Homo sapiens_hsa051690.41716888
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38672414
81Arachidonic acid metabolism_Homo sapiens_hsa005900.37958262
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36916436
83Malaria_Homo sapiens_hsa051440.36797300
84Nicotine addiction_Homo sapiens_hsa050330.36345475
85Phagosome_Homo sapiens_hsa041450.33659185
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.33402120
87Fatty acid elongation_Homo sapiens_hsa000620.33040591
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32558957
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31482834
90Glutathione metabolism_Homo sapiens_hsa004800.31447043
91Measles_Homo sapiens_hsa051620.31169276
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.31135519
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28248578
94Tuberculosis_Homo sapiens_hsa051520.27098820
95Pyruvate metabolism_Homo sapiens_hsa006200.25213661
96Sulfur metabolism_Homo sapiens_hsa009200.24669580
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.23352089
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22438372
99Legionellosis_Homo sapiens_hsa051340.22394236
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21715840

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »