PPIAP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)7.05562080
2establishment of viral latency (GO:0019043)5.75458827
3establishment of integrated proviral latency (GO:0075713)5.65731169
4proteasome assembly (GO:0043248)4.57019859
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.36370820
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.36370820
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.30142031
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18612166
9response to interferon-beta (GO:0035456)4.01647445
10positive regulation of actin filament depolymerization (GO:0030836)3.96849748
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.91661643
12detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.85526940
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.81403834
14cullin deneddylation (GO:0010388)3.79810438
15extracellular fibril organization (GO:0043206)3.79585532
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79552970
17regulation of cellular amino acid metabolic process (GO:0006521)3.78271289
18regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76153620
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75757220
20negative regulation of ligase activity (GO:0051352)3.75757220
21endothelial tube morphogenesis (GO:0061154)3.75481160
22morphogenesis of an endothelium (GO:0003159)3.75481160
23protein deneddylation (GO:0000338)3.73376360
24intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.73007926
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.73007926
26signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69823266
27signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69823266
28signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69823266
29response to gravity (GO:0009629)3.65805838
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.65231426
31regulation of mitochondrial translation (GO:0070129)3.64913183
32signal transduction involved in DNA damage checkpoint (GO:0072422)3.60678246
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60678246
34negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.58347119
35ATP synthesis coupled proton transport (GO:0015986)3.58166966
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58166966
37nuclear envelope reassembly (GO:0031468)3.57841075
38mitotic nuclear envelope reassembly (GO:0007084)3.57841075
39signal transduction involved in cell cycle checkpoint (GO:0072395)3.55189420
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.50981706
41DNA deamination (GO:0045006)3.45055929
42mannosylation (GO:0097502)3.43767893
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.40118320
44GTP biosynthetic process (GO:0006183)3.32506673
45ribosome assembly (GO:0042255)3.30335171
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30007350
47negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.28848714
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28596827
49sequestering of actin monomers (GO:0042989)3.28099023
50protein complex biogenesis (GO:0070271)3.26887179
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.26745445
52GDP-mannose metabolic process (GO:0019673)3.25993357
53regulation of metalloenzyme activity (GO:0048552)3.19095862
54DNA unwinding involved in DNA replication (GO:0006268)3.18520182
55detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.16206551
56telomere maintenance via semi-conservative replication (GO:0032201)3.12932121
57UTP biosynthetic process (GO:0006228)3.12699523
58lipopolysaccharide biosynthetic process (GO:0009103)3.10885639
59muscle cell migration (GO:0014812)3.08231352
60fibril organization (GO:0097435)3.07964777
61positive regulation of ligase activity (GO:0051351)3.07632826
62cellular response to interferon-beta (GO:0035458)3.03899683
63guanosine-containing compound biosynthetic process (GO:1901070)2.96755443
64mitochondrial respiratory chain complex assembly (GO:0033108)2.96416554
65DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.93674218
66termination of RNA polymerase III transcription (GO:0006386)2.92738832
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.92738832
68ribosomal large subunit biogenesis (GO:0042273)2.88045536
69nucleoside transmembrane transport (GO:1901642)2.87046590
70pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.86739922
71negative regulation of B cell apoptotic process (GO:0002903)2.86364362
72pseudouridine synthesis (GO:0001522)2.84056950
73antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83977693
74respiratory electron transport chain (GO:0022904)2.83493236
75transcription-coupled nucleotide-excision repair (GO:0006283)2.83103172
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.82779700
77NADH dehydrogenase complex assembly (GO:0010257)2.82779700
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82779700
79Golgi transport vesicle coating (GO:0048200)2.81340606
80COPI coating of Golgi vesicle (GO:0048205)2.81340606
81dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.80711652
82regulation of ubiquitin-protein transferase activity (GO:0051438)2.80007917
83positive regulation of cell cycle arrest (GO:0071158)2.79616787
84electron transport chain (GO:0022900)2.79591866
85galactose catabolic process (GO:0019388)2.77656495
86maturation of 5.8S rRNA (GO:0000460)2.77401502
87negative regulation of mitochondrion organization (GO:0010823)2.76950112
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76599675
89negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.76526716
90type B pancreatic cell proliferation (GO:0044342)2.76512208
91amino acid salvage (GO:0043102)2.76444637
92L-methionine salvage (GO:0071267)2.76444637
93L-methionine biosynthetic process (GO:0071265)2.76444637
94UTP metabolic process (GO:0046051)2.75438682
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.73376311
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70421840
97negative regulation of protein ubiquitination (GO:0031397)2.70068102
98viral mRNA export from host cell nucleus (GO:0046784)2.68087115
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68046939
100de novo protein folding (GO:0006458)2.67358830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80050162
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.77759509
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59137192
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47529983
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.38798910
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.27357622
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22052479
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.92570607
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.86097857
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79166678
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76341318
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.72760163
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56325839
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55219506
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.48905494
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46009242
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45261588
18E2F7_22180533_ChIP-Seq_HELA_Human2.37305547
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36235736
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35787100
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29481471
22VDR_23849224_ChIP-Seq_CD4+_Human2.25705385
23DCP1A_22483619_ChIP-Seq_HELA_Human2.19075066
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17736661
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11605799
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09106026
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02043445
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97105238
29GABP_19822575_ChIP-Seq_HepG2_Human1.93878759
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.93339610
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92856663
32XRN2_22483619_ChIP-Seq_HELA_Human1.86608987
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85780598
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.85221220
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.84406874
36FOXP3_21729870_ChIP-Seq_TREG_Human1.81618968
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81246324
38ELK1_19687146_ChIP-ChIP_HELA_Human1.76837781
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70900215
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70641659
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70497830
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68678342
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68396472
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67688419
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67051851
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66262623
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65840490
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63356872
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61953295
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60046772
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.57206075
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56971410
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52651339
54TTF2_22483619_ChIP-Seq_HELA_Human1.52615080
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49683172
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46843732
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43745861
58ZNF263_19887448_ChIP-Seq_K562_Human1.43584321
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40376270
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36533718
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33693218
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.32439016
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28361909
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25633457
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24409781
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21846649
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21702039
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21299674
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20779902
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18167038
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17511763
72CIITA_25753668_ChIP-Seq_RAJI_Human1.15303233
73TFEB_21752829_ChIP-Seq_HELA_Human1.14923055
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14882551
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14410064
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13937597
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13198630
78BCL6_27268052_Chip-Seq_Bcells_Human1.12934063
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09458632
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08120628
81KDM5A_27292631_Chip-Seq_BREAST_Human1.07730028
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05592579
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04261601
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.99768914
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99746782
86MYC_18940864_ChIP-ChIP_HL60_Human0.99020763
87FOXM1_23109430_ChIP-Seq_U2OS_Human0.98981943
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.98787070
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96643317
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95243980
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94080935
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.93686485
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93563816
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92899926
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92363059
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91605446
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87478648
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87239376
99SPI1_23547873_ChIP-Seq_NB4_Human0.86806347
100BCOR_27268052_Chip-Seq_Bcells_Human0.86312071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure3.32211073
2MP0005360_urolithiasis2.86257293
3MP0000750_abnormal_muscle_regeneration2.77720683
4MP0001542_abnormal_bone_strength2.71034064
5MP0000751_myopathy2.60578582
6MP0003786_premature_aging2.59016191
7MP0003693_abnormal_embryo_hatching2.46672228
8MP0005645_abnormal_hypothalamus_physiol2.40919666
9MP0008058_abnormal_DNA_repair2.27245250
10MP0008438_abnormal_cutaneous_collagen2.24644419
11MP0003806_abnormal_nucleotide_metabolis2.22119494
12MP0005165_increased_susceptibility_to2.17972686
13MP0000749_muscle_degeneration2.13071387
14MP0009333_abnormal_splenocyte_physiolog1.99812601
15MP0004957_abnormal_blastocyst_morpholog1.96146631
16MP0002877_abnormal_melanocyte_morpholog1.91187740
17MP0003186_abnormal_redox_activity1.90296707
18MP0000685_abnormal_immune_system1.89827709
19MP0010094_abnormal_chromosome_stability1.81567898
20MP0001243_abnormal_dermal_layer1.80396127
21MP0004147_increased_porphyrin_level1.78916802
22MP0003123_paternal_imprinting1.68859282
23MP0002282_abnormal_trachea_morphology1.67289025
24MP0003718_maternal_effect1.66172252
25MP0010030_abnormal_orbit_morphology1.65241769
26MP0002148_abnormal_hypersensitivity_rea1.64483654
27MP0003315_abnormal_perineum_morphology1.63397204
28MP0003191_abnormal_cellular_cholesterol1.62719095
29MP0003111_abnormal_nucleus_morphology1.58785327
30MP0001853_heart_inflammation1.58049251
31MP0005330_cardiomyopathy1.58021278
32MP0009697_abnormal_copulation1.56939404
33MP0005671_abnormal_response_to1.55455648
34MP0008775_abnormal_heart_ventricle1.54098601
35MP0008007_abnormal_cellular_replicative1.50900582
36MP0006036_abnormal_mitochondrial_physio1.50350906
37MP0005670_abnormal_white_adipose1.49405804
38MP0000343_altered_response_to1.48309204
39MP0003436_decreased_susceptibility_to1.48278512
40MP0004272_abnormal_basement_membrane1.46710460
41MP0003077_abnormal_cell_cycle1.43906470
42MP0001835_abnormal_antigen_presentation1.38960841
43MP0001727_abnormal_embryo_implantation1.37500964
44MP0003763_abnormal_thymus_physiology1.35957279
45MP0008932_abnormal_embryonic_tissue1.35535971
46MP0003075_altered_response_to1.31441431
47MP0008789_abnormal_olfactory_epithelium1.31200417
48MP0000858_altered_metastatic_potential1.26629876
49MP0000465_gastrointestinal_hemorrhage1.25696844
50MP0009785_altered_susceptibility_to1.25299344
51MP0004510_myositis1.24072951
52MP0002019_abnormal_tumor_incidence1.23077851
53MP0002332_abnormal_exercise_endurance1.22633115
54MP0003866_abnormal_defecation1.20914845
55MP0002006_tumorigenesis1.19992854
56MP0003950_abnormal_plasma_membrane1.18661946
57MP0000358_abnormal_cell_content/1.12420070
58MP0006054_spinal_hemorrhage1.12244884
59MP0008875_abnormal_xenobiotic_pharmacok1.11177616
60MP0002060_abnormal_skin_morphology1.08809887
61MP0000490_abnormal_crypts_of1.08110820
62MP0006072_abnormal_retinal_apoptosis1.07308295
63MP0004185_abnormal_adipocyte_glucose1.03065419
64MP0002837_dystrophic_cardiac_calcinosis1.02886993
65MP0006035_abnormal_mitochondrial_morpho1.01988464
66MP0010368_abnormal_lymphatic_system1.01464161
67MP0002452_abnormal_antigen_presenting1.00303386
68MP0005000_abnormal_immune_tolerance0.97323763
69MP0010155_abnormal_intestine_physiology0.95394908
70MP0003279_aneurysm0.94626663
71MP0002723_abnormal_immune_serum0.94418392
72MP0001845_abnormal_inflammatory_respons0.92784666
73MP0002166_altered_tumor_susceptibility0.89952497
74MP0005058_abnormal_lysosome_morphology0.89935469
75MP0000689_abnormal_spleen_morphology0.89747620
76MP0005025_abnormal_response_to0.88599802
77MP0005166_decreased_susceptibility_to0.87704309
78MP0005464_abnormal_platelet_physiology0.86615161
79MP0000613_abnormal_salivary_gland0.86604346
80MP0008260_abnormal_autophagy0.86462806
81MP0009764_decreased_sensitivity_to0.86435377
82MP0002722_abnormal_immune_system0.86149035
83MP0001790_abnormal_immune_system0.86072993
84MP0005387_immune_system_phenotype0.86072993
85MP0008469_abnormal_protein_level0.85420667
86MP0000747_muscle_weakness0.84391483
87MP0005367_renal/urinary_system_phenotyp0.83787657
88MP0000516_abnormal_urinary_system0.83787657
89MP0001905_abnormal_dopamine_level0.83787169
90MP0001819_abnormal_immune_cell0.82614496
91MP0009840_abnormal_foam_cell0.82454553
92MP0002420_abnormal_adaptive_immunity0.82293392
93MP0005584_abnormal_enzyme/coenzyme_acti0.79379599
94MP0002138_abnormal_hepatobiliary_system0.75302561
95MP0001800_abnormal_humoral_immune0.73401293
96MP0002106_abnormal_muscle_physiology0.73103854
97MP0001533_abnormal_skeleton_physiology0.73072303
98MP0002429_abnormal_blood_cell0.71774939
99MP0002177_abnormal_outer_ear0.70760938
100MP0000013_abnormal_adipose_tissue0.70266702

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.21542084
2Mitochondrial inheritance (HP:0001427)4.06664339
3Acute necrotizing encephalopathy (HP:0006965)4.00942498
4Abnormal mitochondria in muscle tissue (HP:0008316)3.99712998
5Hepatic necrosis (HP:0002605)3.86324453
6Reduced subcutaneous adipose tissue (HP:0003758)3.79524960
7Glucose intolerance (HP:0000833)3.77361229
8Increased CSF lactate (HP:0002490)3.69656531
9Type I transferrin isoform profile (HP:0003642)3.64477740
10Delayed CNS myelination (HP:0002188)3.51473886
11Adrenal hypoplasia (HP:0000835)3.49279910
12Premature rupture of membranes (HP:0001788)3.47317852
13Reduced antithrombin III activity (HP:0001976)3.46519075
14Acute encephalopathy (HP:0006846)3.39341545
15Entropion (HP:0000621)3.29271102
16Abnormal protein glycosylation (HP:0012346)3.15770551
17Abnormal glycosylation (HP:0012345)3.15770551
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15770551
19Abnormal protein N-linked glycosylation (HP:0012347)3.15770551
20Rough bone trabeculation (HP:0100670)3.14227817
21Progressive macrocephaly (HP:0004481)3.11064537
22Elevated erythrocyte sedimentation rate (HP:0003565)3.08616822
23Increased serum lactate (HP:0002151)3.04185606
24Increased hepatocellular lipid droplets (HP:0006565)3.03899429
25Increased serum pyruvate (HP:0003542)2.94859029
26Cerebral edema (HP:0002181)2.90542960
27Upper limb muscle weakness (HP:0003484)2.74791039
28Lactic acidosis (HP:0003128)2.73335255
29Exercise intolerance (HP:0003546)2.72597722
30Lipid accumulation in hepatocytes (HP:0006561)2.72417441
31Renal Fanconi syndrome (HP:0001994)2.70881416
32Abnormality of glycolysis (HP:0004366)2.65840733
33Increased intramyocellular lipid droplets (HP:0012240)2.58245046
34Sparse eyelashes (HP:0000653)2.51672137
35Amyloidosis (HP:0011034)2.48747339
36Secondary amenorrhea (HP:0000869)2.47389423
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44589107
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41936374
39Abnormality of alanine metabolism (HP:0010916)2.41936374
40Hyperalaninemia (HP:0003348)2.41936374
41Respiratory failure (HP:0002878)2.39838106
42IgG deficiency (HP:0004315)2.36981516
43Abnormal gallbladder physiology (HP:0012438)2.36140493
44Cholecystitis (HP:0001082)2.36140493
45Congenital, generalized hypertrichosis (HP:0004540)2.36105971
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36073100
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36073100
48Severe muscular hypotonia (HP:0006829)2.34616763
49Hepatosplenomegaly (HP:0001433)2.31395750
50Abnormal trabecular bone morphology (HP:0100671)2.31283468
51Progressive microcephaly (HP:0000253)2.29477156
52Emotional lability (HP:0000712)2.28700094
53Degeneration of anterior horn cells (HP:0002398)2.26247254
54Abnormality of the anterior horn cell (HP:0006802)2.26247254
55Abnormal glucose tolerance (HP:0001952)2.25505973
56Trismus (HP:0000211)2.23484638
57Opisthotonus (HP:0002179)2.19848508
58CNS demyelination (HP:0007305)2.18418017
59Abnormality of the distal phalanges of the toes (HP:0010182)2.16005012
60Increased muscle lipid content (HP:0009058)2.15709987
61Tongue fasciculations (HP:0001308)2.13967280
62Vertebral compression fractures (HP:0002953)2.13110971
63Insulin resistance (HP:0000855)2.11606153
64Hypergonadotropic hypogonadism (HP:0000815)2.07747442
65Decreased subcutaneous fat (HP:0001002)2.06746528
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05893943
67Progressive muscle weakness (HP:0003323)2.03939456
68Exertional dyspnea (HP:0002875)2.01440375
69Prostate neoplasm (HP:0100787)2.00670226
70Flat capital femoral epiphysis (HP:0003370)2.00264523
71Testicular atrophy (HP:0000029)2.00189244
72Hand muscle atrophy (HP:0009130)1.99792421
73Palpitations (HP:0001962)1.99006733
74Pancytopenia (HP:0001876)1.94710229
75Microretrognathia (HP:0000308)1.93549334
76IgM deficiency (HP:0002850)1.93374662
77Optic disc pallor (HP:0000543)1.92231429
78Pendular nystagmus (HP:0012043)1.89539449
79Methylmalonic aciduria (HP:0012120)1.88393121
80Carpal bone hypoplasia (HP:0001498)1.87820047
81Osteolytic defects of the phalanges of the hand (HP:0009771)1.86630834
82Osteolytic defects of the hand bones (HP:0009699)1.86630834
83Microglossia (HP:0000171)1.85370806
84Premature ovarian failure (HP:0008209)1.85246548
85Cerebral hypomyelination (HP:0006808)1.83504000
86Growth hormone excess (HP:0000845)1.83124644
87Erythema (HP:0010783)1.82885011
88Short nail (HP:0001799)1.82158137
89Onycholysis (HP:0001806)1.81991455
90Conjugated hyperbilirubinemia (HP:0002908)1.80773386
91Increased IgM level (HP:0003496)1.80155242
92Aplasia/hypoplasia of the uterus (HP:0008684)1.79712247
93Abnormality of the umbilical cord (HP:0010881)1.79501480
94Prolonged neonatal jaundice (HP:0006579)1.77406674
95Hypoplasia of the uterus (HP:0000013)1.76158716
96Aplastic anemia (HP:0001915)1.75343015
97Distal lower limb muscle weakness (HP:0009053)1.73850150
98Abnormal pupillary function (HP:0007686)1.73626589
99Generalized aminoaciduria (HP:0002909)1.73413764
100Fatigue (HP:0012378)1.72947253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.30521131
2TESK15.03148676
3TESK24.90678824
4NME24.86200436
5LIMK13.90140314
6BUB13.16095296
7MST1R2.57830869
8EPHA22.39147580
9BCKDK2.31546736
10ARAF2.23263914
11LMTK22.07069044
12PIM22.03193636
13KDR2.02024736
14VRK11.93985964
15MST41.92890139
16MAP2K71.83332762
17SRPK11.80652716
18DAPK11.72304796
19TAF11.49253017
20CDK81.30385256
21CSNK1G31.27254272
22PAK41.26051682
23SCYL21.24140881
24TLK11.23241693
25ERN11.23101611
26NEK11.17870544
27CSNK1A1L1.17111108
28PBK1.15030702
29AURKA1.13837821
30CCNB11.07930390
31MAPKAPK31.02877942
32STK101.02458278
33ABL21.02074270
34PHKG21.00589548
35PHKG11.00589548
36WNK40.97088319
37TAOK20.94428969
38CSNK1G10.88977668
39STK160.88871281
40ZAK0.88821450
41NUAK10.86367014
42ERBB40.84451815
43CDK190.83168428
44MAP4K20.80286301
45DAPK30.77895457
46TBK10.76776510
47MOS0.75799923
48RPS6KA50.74780643
49CSNK1G20.74501662
50IRAK30.74314108
51STK390.66515121
52MYLK0.65813502
53MET0.64644189
54BRAF0.63923746
55CDK70.63500206
56TIE10.63071184
57AURKB0.62831177
58PAK10.61241968
59PLK40.59928689
60EIF2AK30.57615046
61PTK2B0.57409927
62BCR0.54918436
63ILK0.54462170
64HIPK20.52060093
65MUSK0.51974545
66PLK10.51832246
67PRKCI0.51492600
68PTK20.49920106
69MAP3K120.49615579
70OXSR10.48428695
71NME10.48325204
72SIK30.44899472
73EIF2AK20.44605674
74BMPR20.44250322
75BRSK10.43902797
76EIF2AK10.38311046
77SMG10.38281742
78CSNK2A20.37885448
79CHEK20.37794313
80MAPKAPK50.37746049
81MAP3K110.37626494
82ERBB30.37298975
83GRK50.35991700
84PDK20.35847160
85IKBKB0.35086340
86GRK70.32023266
87CSNK2A10.29835381
88CDC70.29027366
89ATR0.29017046
90CDK140.28886322
91IKBKE0.27270933
92LRRK20.26948965
93CDK11A0.26098227
94MAP3K80.25430263
95CDK180.23593590
96MAPKAPK20.22852863
97CDK150.22570611
98RAF10.22395392
99TSSK60.20008860
100CDK90.19194880

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.90672092
2DNA replication_Homo sapiens_hsa030303.49081695
3Oxidative phosphorylation_Homo sapiens_hsa001902.98526795
4Base excision repair_Homo sapiens_hsa034102.60470876
5Mismatch repair_Homo sapiens_hsa034302.54635150
6Parkinsons disease_Homo sapiens_hsa050122.53375275
7RNA polymerase_Homo sapiens_hsa030202.45794525
8Fatty acid elongation_Homo sapiens_hsa000622.43403687
9Pyrimidine metabolism_Homo sapiens_hsa002402.33557352
10Ribosome_Homo sapiens_hsa030102.28214830
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25313557
12Nucleotide excision repair_Homo sapiens_hsa034202.19818253
13Sulfur relay system_Homo sapiens_hsa041222.01691598
14Huntingtons disease_Homo sapiens_hsa050161.91171527
15Alzheimers disease_Homo sapiens_hsa050101.81606802
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70280604
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68077729
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66688305
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60554442
20Homologous recombination_Homo sapiens_hsa034401.53626775
21Biosynthesis of amino acids_Homo sapiens_hsa012301.53215383
22Folate biosynthesis_Homo sapiens_hsa007901.53041214
23Systemic lupus erythematosus_Homo sapiens_hsa053221.51277497
24Pentose phosphate pathway_Homo sapiens_hsa000301.50661504
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49870216
26Glutathione metabolism_Homo sapiens_hsa004801.46040847
27Spliceosome_Homo sapiens_hsa030401.42249887
28Sulfur metabolism_Homo sapiens_hsa009201.38973963
29N-Glycan biosynthesis_Homo sapiens_hsa005101.38714446
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32057910
31RNA transport_Homo sapiens_hsa030131.29002495
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25969804
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24564617
34Purine metabolism_Homo sapiens_hsa002301.24275705
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23918557
36Primary immunodeficiency_Homo sapiens_hsa053401.21487060
37Galactose metabolism_Homo sapiens_hsa000521.20382936
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18729842
39Carbon metabolism_Homo sapiens_hsa012001.17769301
40Viral myocarditis_Homo sapiens_hsa054161.16368470
41Pyruvate metabolism_Homo sapiens_hsa006201.15696301
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.15068398
43Fructose and mannose metabolism_Homo sapiens_hsa000511.11801182
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10655461
45Allograft rejection_Homo sapiens_hsa053301.07439453
46Autoimmune thyroid disease_Homo sapiens_hsa053201.02211303
47Asthma_Homo sapiens_hsa053101.01286436
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.00938537
49RNA degradation_Homo sapiens_hsa030180.98738434
50Antigen processing and presentation_Homo sapiens_hsa046120.95489413
51Vibrio cholerae infection_Homo sapiens_hsa051100.93083526
52Basal transcription factors_Homo sapiens_hsa030220.92678274
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88088649
54Protein export_Homo sapiens_hsa030600.87733533
55Shigellosis_Homo sapiens_hsa051310.86204305
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86028490
57Non-homologous end-joining_Homo sapiens_hsa034500.85281107
58Graft-versus-host disease_Homo sapiens_hsa053320.82831422
59Epstein-Barr virus infection_Homo sapiens_hsa051690.79047381
60Fanconi anemia pathway_Homo sapiens_hsa034600.77864706
61Alcoholism_Homo sapiens_hsa050340.76515331
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76130566
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.75361207
64Salivary secretion_Homo sapiens_hsa049700.75247566
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75216808
66One carbon pool by folate_Homo sapiens_hsa006700.73779608
67Metabolic pathways_Homo sapiens_hsa011000.69838653
68Cardiac muscle contraction_Homo sapiens_hsa042600.67350588
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66484138
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65200228
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65090769
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.64612486
73Type I diabetes mellitus_Homo sapiens_hsa049400.63287334
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.62991425
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62879494
76Phenylalanine metabolism_Homo sapiens_hsa003600.59619304
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58682652
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57544262
79Herpes simplex infection_Homo sapiens_hsa051680.56000379
80Cell cycle_Homo sapiens_hsa041100.55534354
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51583351
82p53 signaling pathway_Homo sapiens_hsa041150.50057443
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49608108
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.47325089
85Rheumatoid arthritis_Homo sapiens_hsa053230.45414650
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43698402
87Propanoate metabolism_Homo sapiens_hsa006400.43227307
88Hematopoietic cell lineage_Homo sapiens_hsa046400.42472371
89Peroxisome_Homo sapiens_hsa041460.41421994
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39695420
91Apoptosis_Homo sapiens_hsa042100.37755376
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36039880
93Viral carcinogenesis_Homo sapiens_hsa052030.34469276
94Steroid biosynthesis_Homo sapiens_hsa001000.33947872
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.31431767
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31075725
97Oocyte meiosis_Homo sapiens_hsa041140.28659794
98Arachidonic acid metabolism_Homo sapiens_hsa005900.28633862
99Tyrosine metabolism_Homo sapiens_hsa003500.28623364
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25696371

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