

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein maturation by protein folding (GO:0022417) | 7.05562080 |
| 2 | establishment of viral latency (GO:0019043) | 5.75458827 |
| 3 | establishment of integrated proviral latency (GO:0075713) | 5.65731169 |
| 4 | proteasome assembly (GO:0043248) | 4.57019859 |
| 5 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.36370820 |
| 6 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.36370820 |
| 7 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.30142031 |
| 8 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.18612166 |
| 9 | response to interferon-beta (GO:0035456) | 4.01647445 |
| 10 | positive regulation of actin filament depolymerization (GO:0030836) | 3.96849748 |
| 11 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.91661643 |
| 12 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 3.85526940 |
| 13 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.81403834 |
| 14 | cullin deneddylation (GO:0010388) | 3.79810438 |
| 15 | extracellular fibril organization (GO:0043206) | 3.79585532 |
| 16 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.79552970 |
| 17 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.78271289 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.76153620 |
| 19 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.75757220 |
| 20 | negative regulation of ligase activity (GO:0051352) | 3.75757220 |
| 21 | endothelial tube morphogenesis (GO:0061154) | 3.75481160 |
| 22 | morphogenesis of an endothelium (GO:0003159) | 3.75481160 |
| 23 | protein deneddylation (GO:0000338) | 3.73376360 |
| 24 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.73007926 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.73007926 |
| 26 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.69823266 |
| 27 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.69823266 |
| 28 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.69823266 |
| 29 | response to gravity (GO:0009629) | 3.65805838 |
| 30 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.65231426 |
| 31 | regulation of mitochondrial translation (GO:0070129) | 3.64913183 |
| 32 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.60678246 |
| 33 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.60678246 |
| 34 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 3.58347119 |
| 35 | ATP synthesis coupled proton transport (GO:0015986) | 3.58166966 |
| 36 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.58166966 |
| 37 | nuclear envelope reassembly (GO:0031468) | 3.57841075 |
| 38 | mitotic nuclear envelope reassembly (GO:0007084) | 3.57841075 |
| 39 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.55189420 |
| 40 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.50981706 |
| 41 | DNA deamination (GO:0045006) | 3.45055929 |
| 42 | mannosylation (GO:0097502) | 3.43767893 |
| 43 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.40118320 |
| 44 | GTP biosynthetic process (GO:0006183) | 3.32506673 |
| 45 | ribosome assembly (GO:0042255) | 3.30335171 |
| 46 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.30007350 |
| 47 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.28848714 |
| 48 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.28596827 |
| 49 | sequestering of actin monomers (GO:0042989) | 3.28099023 |
| 50 | protein complex biogenesis (GO:0070271) | 3.26887179 |
| 51 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 3.26745445 |
| 52 | GDP-mannose metabolic process (GO:0019673) | 3.25993357 |
| 53 | regulation of metalloenzyme activity (GO:0048552) | 3.19095862 |
| 54 | DNA unwinding involved in DNA replication (GO:0006268) | 3.18520182 |
| 55 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 3.16206551 |
| 56 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.12932121 |
| 57 | UTP biosynthetic process (GO:0006228) | 3.12699523 |
| 58 | lipopolysaccharide biosynthetic process (GO:0009103) | 3.10885639 |
| 59 | muscle cell migration (GO:0014812) | 3.08231352 |
| 60 | fibril organization (GO:0097435) | 3.07964777 |
| 61 | positive regulation of ligase activity (GO:0051351) | 3.07632826 |
| 62 | cellular response to interferon-beta (GO:0035458) | 3.03899683 |
| 63 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.96755443 |
| 64 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.96416554 |
| 65 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.93674218 |
| 66 | termination of RNA polymerase III transcription (GO:0006386) | 2.92738832 |
| 67 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.92738832 |
| 68 | ribosomal large subunit biogenesis (GO:0042273) | 2.88045536 |
| 69 | nucleoside transmembrane transport (GO:1901642) | 2.87046590 |
| 70 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.86739922 |
| 71 | negative regulation of B cell apoptotic process (GO:0002903) | 2.86364362 |
| 72 | pseudouridine synthesis (GO:0001522) | 2.84056950 |
| 73 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.83977693 |
| 74 | respiratory electron transport chain (GO:0022904) | 2.83493236 |
| 75 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.83103172 |
| 76 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.82779700 |
| 77 | NADH dehydrogenase complex assembly (GO:0010257) | 2.82779700 |
| 78 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.82779700 |
| 79 | Golgi transport vesicle coating (GO:0048200) | 2.81340606 |
| 80 | COPI coating of Golgi vesicle (GO:0048205) | 2.81340606 |
| 81 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.80711652 |
| 82 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.80007917 |
| 83 | positive regulation of cell cycle arrest (GO:0071158) | 2.79616787 |
| 84 | electron transport chain (GO:0022900) | 2.79591866 |
| 85 | galactose catabolic process (GO:0019388) | 2.77656495 |
| 86 | maturation of 5.8S rRNA (GO:0000460) | 2.77401502 |
| 87 | negative regulation of mitochondrion organization (GO:0010823) | 2.76950112 |
| 88 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.76599675 |
| 89 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.76526716 |
| 90 | type B pancreatic cell proliferation (GO:0044342) | 2.76512208 |
| 91 | amino acid salvage (GO:0043102) | 2.76444637 |
| 92 | L-methionine salvage (GO:0071267) | 2.76444637 |
| 93 | L-methionine biosynthetic process (GO:0071265) | 2.76444637 |
| 94 | UTP metabolic process (GO:0046051) | 2.75438682 |
| 95 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.73376311 |
| 96 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.70421840 |
| 97 | negative regulation of protein ubiquitination (GO:0031397) | 2.70068102 |
| 98 | viral mRNA export from host cell nucleus (GO:0046784) | 2.68087115 |
| 99 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.68046939 |
| 100 | de novo protein folding (GO:0006458) | 2.67358830 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.80050162 |
| 2 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.77759509 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.59137192 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.47529983 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.38798910 |
| 6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.27357622 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.22052479 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.92570607 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.86097857 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.79166678 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.76341318 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.72760163 |
| 13 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.56325839 |
| 14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.55219506 |
| 15 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.48905494 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.46009242 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.45261588 |
| 18 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.37305547 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.36235736 |
| 20 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.35787100 |
| 21 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.29481471 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.25705385 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.19075066 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17736661 |
| 25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.11605799 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.09106026 |
| 27 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.02043445 |
| 28 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.97105238 |
| 29 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93878759 |
| 30 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.93339610 |
| 31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.92856663 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.86608987 |
| 33 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.85780598 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.85221220 |
| 35 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.84406874 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.81618968 |
| 37 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.81246324 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.76837781 |
| 39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.70900215 |
| 40 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.70641659 |
| 41 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.70497830 |
| 42 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.68678342 |
| 43 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.68396472 |
| 44 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.67688419 |
| 45 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.67051851 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66262623 |
| 47 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.65840490 |
| 48 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.63356872 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61953295 |
| 50 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.60046772 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.57206075 |
| 52 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.56971410 |
| 53 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.52651339 |
| 54 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.52615080 |
| 55 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.49683172 |
| 56 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.46843732 |
| 57 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.43745861 |
| 58 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.43584321 |
| 59 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.40376270 |
| 60 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.36533718 |
| 61 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.33693218 |
| 62 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.32439016 |
| 63 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.28361909 |
| 64 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.25633457 |
| 65 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.24409781 |
| 66 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.21846649 |
| 67 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.21702039 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.21299674 |
| 69 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20779902 |
| 70 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.18167038 |
| 71 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.17511763 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.15303233 |
| 73 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.14923055 |
| 74 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.14882551 |
| 75 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.14410064 |
| 76 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13937597 |
| 77 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.13198630 |
| 78 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.12934063 |
| 79 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.09458632 |
| 80 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08120628 |
| 81 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.07730028 |
| 82 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.05592579 |
| 83 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04261601 |
| 84 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.99768914 |
| 85 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.99746782 |
| 86 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.99020763 |
| 87 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.98981943 |
| 88 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.98787070 |
| 89 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.96643317 |
| 90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.95243980 |
| 91 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.94080935 |
| 92 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.93686485 |
| 93 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.93563816 |
| 94 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.92899926 |
| 95 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.92363059 |
| 96 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.91605446 |
| 97 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.87478648 |
| 98 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.87239376 |
| 99 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.86806347 |
| 100 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.86312071 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005257_abnormal_intraocular_pressure | 3.32211073 |
| 2 | MP0005360_urolithiasis | 2.86257293 |
| 3 | MP0000750_abnormal_muscle_regeneration | 2.77720683 |
| 4 | MP0001542_abnormal_bone_strength | 2.71034064 |
| 5 | MP0000751_myopathy | 2.60578582 |
| 6 | MP0003786_premature_aging | 2.59016191 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.46672228 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.40919666 |
| 9 | MP0008058_abnormal_DNA_repair | 2.27245250 |
| 10 | MP0008438_abnormal_cutaneous_collagen | 2.24644419 |
| 11 | MP0003806_abnormal_nucleotide_metabolis | 2.22119494 |
| 12 | MP0005165_increased_susceptibility_to | 2.17972686 |
| 13 | MP0000749_muscle_degeneration | 2.13071387 |
| 14 | MP0009333_abnormal_splenocyte_physiolog | 1.99812601 |
| 15 | MP0004957_abnormal_blastocyst_morpholog | 1.96146631 |
| 16 | MP0002877_abnormal_melanocyte_morpholog | 1.91187740 |
| 17 | MP0003186_abnormal_redox_activity | 1.90296707 |
| 18 | MP0000685_abnormal_immune_system | 1.89827709 |
| 19 | MP0010094_abnormal_chromosome_stability | 1.81567898 |
| 20 | MP0001243_abnormal_dermal_layer | 1.80396127 |
| 21 | MP0004147_increased_porphyrin_level | 1.78916802 |
| 22 | MP0003123_paternal_imprinting | 1.68859282 |
| 23 | MP0002282_abnormal_trachea_morphology | 1.67289025 |
| 24 | MP0003718_maternal_effect | 1.66172252 |
| 25 | MP0010030_abnormal_orbit_morphology | 1.65241769 |
| 26 | MP0002148_abnormal_hypersensitivity_rea | 1.64483654 |
| 27 | MP0003315_abnormal_perineum_morphology | 1.63397204 |
| 28 | MP0003191_abnormal_cellular_cholesterol | 1.62719095 |
| 29 | MP0003111_abnormal_nucleus_morphology | 1.58785327 |
| 30 | MP0001853_heart_inflammation | 1.58049251 |
| 31 | MP0005330_cardiomyopathy | 1.58021278 |
| 32 | MP0009697_abnormal_copulation | 1.56939404 |
| 33 | MP0005671_abnormal_response_to | 1.55455648 |
| 34 | MP0008775_abnormal_heart_ventricle | 1.54098601 |
| 35 | MP0008007_abnormal_cellular_replicative | 1.50900582 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.50350906 |
| 37 | MP0005670_abnormal_white_adipose | 1.49405804 |
| 38 | MP0000343_altered_response_to | 1.48309204 |
| 39 | MP0003436_decreased_susceptibility_to | 1.48278512 |
| 40 | MP0004272_abnormal_basement_membrane | 1.46710460 |
| 41 | MP0003077_abnormal_cell_cycle | 1.43906470 |
| 42 | MP0001835_abnormal_antigen_presentation | 1.38960841 |
| 43 | MP0001727_abnormal_embryo_implantation | 1.37500964 |
| 44 | MP0003763_abnormal_thymus_physiology | 1.35957279 |
| 45 | MP0008932_abnormal_embryonic_tissue | 1.35535971 |
| 46 | MP0003075_altered_response_to | 1.31441431 |
| 47 | MP0008789_abnormal_olfactory_epithelium | 1.31200417 |
| 48 | MP0000858_altered_metastatic_potential | 1.26629876 |
| 49 | MP0000465_gastrointestinal_hemorrhage | 1.25696844 |
| 50 | MP0009785_altered_susceptibility_to | 1.25299344 |
| 51 | MP0004510_myositis | 1.24072951 |
| 52 | MP0002019_abnormal_tumor_incidence | 1.23077851 |
| 53 | MP0002332_abnormal_exercise_endurance | 1.22633115 |
| 54 | MP0003866_abnormal_defecation | 1.20914845 |
| 55 | MP0002006_tumorigenesis | 1.19992854 |
| 56 | MP0003950_abnormal_plasma_membrane | 1.18661946 |
| 57 | MP0000358_abnormal_cell_content/ | 1.12420070 |
| 58 | MP0006054_spinal_hemorrhage | 1.12244884 |
| 59 | MP0008875_abnormal_xenobiotic_pharmacok | 1.11177616 |
| 60 | MP0002060_abnormal_skin_morphology | 1.08809887 |
| 61 | MP0000490_abnormal_crypts_of | 1.08110820 |
| 62 | MP0006072_abnormal_retinal_apoptosis | 1.07308295 |
| 63 | MP0004185_abnormal_adipocyte_glucose | 1.03065419 |
| 64 | MP0002837_dystrophic_cardiac_calcinosis | 1.02886993 |
| 65 | MP0006035_abnormal_mitochondrial_morpho | 1.01988464 |
| 66 | MP0010368_abnormal_lymphatic_system | 1.01464161 |
| 67 | MP0002452_abnormal_antigen_presenting | 1.00303386 |
| 68 | MP0005000_abnormal_immune_tolerance | 0.97323763 |
| 69 | MP0010155_abnormal_intestine_physiology | 0.95394908 |
| 70 | MP0003279_aneurysm | 0.94626663 |
| 71 | MP0002723_abnormal_immune_serum | 0.94418392 |
| 72 | MP0001845_abnormal_inflammatory_respons | 0.92784666 |
| 73 | MP0002166_altered_tumor_susceptibility | 0.89952497 |
| 74 | MP0005058_abnormal_lysosome_morphology | 0.89935469 |
| 75 | MP0000689_abnormal_spleen_morphology | 0.89747620 |
| 76 | MP0005025_abnormal_response_to | 0.88599802 |
| 77 | MP0005166_decreased_susceptibility_to | 0.87704309 |
| 78 | MP0005464_abnormal_platelet_physiology | 0.86615161 |
| 79 | MP0000613_abnormal_salivary_gland | 0.86604346 |
| 80 | MP0008260_abnormal_autophagy | 0.86462806 |
| 81 | MP0009764_decreased_sensitivity_to | 0.86435377 |
| 82 | MP0002722_abnormal_immune_system | 0.86149035 |
| 83 | MP0001790_abnormal_immune_system | 0.86072993 |
| 84 | MP0005387_immune_system_phenotype | 0.86072993 |
| 85 | MP0008469_abnormal_protein_level | 0.85420667 |
| 86 | MP0000747_muscle_weakness | 0.84391483 |
| 87 | MP0005367_renal/urinary_system_phenotyp | 0.83787657 |
| 88 | MP0000516_abnormal_urinary_system | 0.83787657 |
| 89 | MP0001905_abnormal_dopamine_level | 0.83787169 |
| 90 | MP0001819_abnormal_immune_cell | 0.82614496 |
| 91 | MP0009840_abnormal_foam_cell | 0.82454553 |
| 92 | MP0002420_abnormal_adaptive_immunity | 0.82293392 |
| 93 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.79379599 |
| 94 | MP0002138_abnormal_hepatobiliary_system | 0.75302561 |
| 95 | MP0001800_abnormal_humoral_immune | 0.73401293 |
| 96 | MP0002106_abnormal_muscle_physiology | 0.73103854 |
| 97 | MP0001533_abnormal_skeleton_physiology | 0.73072303 |
| 98 | MP0002429_abnormal_blood_cell | 0.71774939 |
| 99 | MP0002177_abnormal_outer_ear | 0.70760938 |
| 100 | MP0000013_abnormal_adipose_tissue | 0.70266702 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hepatocellular necrosis (HP:0001404) | 4.21542084 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.06664339 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.00942498 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.99712998 |
| 5 | Hepatic necrosis (HP:0002605) | 3.86324453 |
| 6 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.79524960 |
| 7 | Glucose intolerance (HP:0000833) | 3.77361229 |
| 8 | Increased CSF lactate (HP:0002490) | 3.69656531 |
| 9 | Type I transferrin isoform profile (HP:0003642) | 3.64477740 |
| 10 | Delayed CNS myelination (HP:0002188) | 3.51473886 |
| 11 | Adrenal hypoplasia (HP:0000835) | 3.49279910 |
| 12 | Premature rupture of membranes (HP:0001788) | 3.47317852 |
| 13 | Reduced antithrombin III activity (HP:0001976) | 3.46519075 |
| 14 | Acute encephalopathy (HP:0006846) | 3.39341545 |
| 15 | Entropion (HP:0000621) | 3.29271102 |
| 16 | Abnormal protein glycosylation (HP:0012346) | 3.15770551 |
| 17 | Abnormal glycosylation (HP:0012345) | 3.15770551 |
| 18 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.15770551 |
| 19 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.15770551 |
| 20 | Rough bone trabeculation (HP:0100670) | 3.14227817 |
| 21 | Progressive macrocephaly (HP:0004481) | 3.11064537 |
| 22 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.08616822 |
| 23 | Increased serum lactate (HP:0002151) | 3.04185606 |
| 24 | Increased hepatocellular lipid droplets (HP:0006565) | 3.03899429 |
| 25 | Increased serum pyruvate (HP:0003542) | 2.94859029 |
| 26 | Cerebral edema (HP:0002181) | 2.90542960 |
| 27 | Upper limb muscle weakness (HP:0003484) | 2.74791039 |
| 28 | Lactic acidosis (HP:0003128) | 2.73335255 |
| 29 | Exercise intolerance (HP:0003546) | 2.72597722 |
| 30 | Lipid accumulation in hepatocytes (HP:0006561) | 2.72417441 |
| 31 | Renal Fanconi syndrome (HP:0001994) | 2.70881416 |
| 32 | Abnormality of glycolysis (HP:0004366) | 2.65840733 |
| 33 | Increased intramyocellular lipid droplets (HP:0012240) | 2.58245046 |
| 34 | Sparse eyelashes (HP:0000653) | 2.51672137 |
| 35 | Amyloidosis (HP:0011034) | 2.48747339 |
| 36 | Secondary amenorrhea (HP:0000869) | 2.47389423 |
| 37 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.44589107 |
| 38 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.41936374 |
| 39 | Abnormality of alanine metabolism (HP:0010916) | 2.41936374 |
| 40 | Hyperalaninemia (HP:0003348) | 2.41936374 |
| 41 | Respiratory failure (HP:0002878) | 2.39838106 |
| 42 | IgG deficiency (HP:0004315) | 2.36981516 |
| 43 | Abnormal gallbladder physiology (HP:0012438) | 2.36140493 |
| 44 | Cholecystitis (HP:0001082) | 2.36140493 |
| 45 | Congenital, generalized hypertrichosis (HP:0004540) | 2.36105971 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.36073100 |
| 47 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.36073100 |
| 48 | Severe muscular hypotonia (HP:0006829) | 2.34616763 |
| 49 | Hepatosplenomegaly (HP:0001433) | 2.31395750 |
| 50 | Abnormal trabecular bone morphology (HP:0100671) | 2.31283468 |
| 51 | Progressive microcephaly (HP:0000253) | 2.29477156 |
| 52 | Emotional lability (HP:0000712) | 2.28700094 |
| 53 | Degeneration of anterior horn cells (HP:0002398) | 2.26247254 |
| 54 | Abnormality of the anterior horn cell (HP:0006802) | 2.26247254 |
| 55 | Abnormal glucose tolerance (HP:0001952) | 2.25505973 |
| 56 | Trismus (HP:0000211) | 2.23484638 |
| 57 | Opisthotonus (HP:0002179) | 2.19848508 |
| 58 | CNS demyelination (HP:0007305) | 2.18418017 |
| 59 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.16005012 |
| 60 | Increased muscle lipid content (HP:0009058) | 2.15709987 |
| 61 | Tongue fasciculations (HP:0001308) | 2.13967280 |
| 62 | Vertebral compression fractures (HP:0002953) | 2.13110971 |
| 63 | Insulin resistance (HP:0000855) | 2.11606153 |
| 64 | Hypergonadotropic hypogonadism (HP:0000815) | 2.07747442 |
| 65 | Decreased subcutaneous fat (HP:0001002) | 2.06746528 |
| 66 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.05893943 |
| 67 | Progressive muscle weakness (HP:0003323) | 2.03939456 |
| 68 | Exertional dyspnea (HP:0002875) | 2.01440375 |
| 69 | Prostate neoplasm (HP:0100787) | 2.00670226 |
| 70 | Flat capital femoral epiphysis (HP:0003370) | 2.00264523 |
| 71 | Testicular atrophy (HP:0000029) | 2.00189244 |
| 72 | Hand muscle atrophy (HP:0009130) | 1.99792421 |
| 73 | Palpitations (HP:0001962) | 1.99006733 |
| 74 | Pancytopenia (HP:0001876) | 1.94710229 |
| 75 | Microretrognathia (HP:0000308) | 1.93549334 |
| 76 | IgM deficiency (HP:0002850) | 1.93374662 |
| 77 | Optic disc pallor (HP:0000543) | 1.92231429 |
| 78 | Pendular nystagmus (HP:0012043) | 1.89539449 |
| 79 | Methylmalonic aciduria (HP:0012120) | 1.88393121 |
| 80 | Carpal bone hypoplasia (HP:0001498) | 1.87820047 |
| 81 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.86630834 |
| 82 | Osteolytic defects of the hand bones (HP:0009699) | 1.86630834 |
| 83 | Microglossia (HP:0000171) | 1.85370806 |
| 84 | Premature ovarian failure (HP:0008209) | 1.85246548 |
| 85 | Cerebral hypomyelination (HP:0006808) | 1.83504000 |
| 86 | Growth hormone excess (HP:0000845) | 1.83124644 |
| 87 | Erythema (HP:0010783) | 1.82885011 |
| 88 | Short nail (HP:0001799) | 1.82158137 |
| 89 | Onycholysis (HP:0001806) | 1.81991455 |
| 90 | Conjugated hyperbilirubinemia (HP:0002908) | 1.80773386 |
| 91 | Increased IgM level (HP:0003496) | 1.80155242 |
| 92 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.79712247 |
| 93 | Abnormality of the umbilical cord (HP:0010881) | 1.79501480 |
| 94 | Prolonged neonatal jaundice (HP:0006579) | 1.77406674 |
| 95 | Hypoplasia of the uterus (HP:0000013) | 1.76158716 |
| 96 | Aplastic anemia (HP:0001915) | 1.75343015 |
| 97 | Distal lower limb muscle weakness (HP:0009053) | 1.73850150 |
| 98 | Abnormal pupillary function (HP:0007686) | 1.73626589 |
| 99 | Generalized aminoaciduria (HP:0002909) | 1.73413764 |
| 100 | Fatigue (HP:0012378) | 1.72947253 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.30521131 |
| 2 | TESK1 | 5.03148676 |
| 3 | TESK2 | 4.90678824 |
| 4 | NME2 | 4.86200436 |
| 5 | LIMK1 | 3.90140314 |
| 6 | BUB1 | 3.16095296 |
| 7 | MST1R | 2.57830869 |
| 8 | EPHA2 | 2.39147580 |
| 9 | BCKDK | 2.31546736 |
| 10 | ARAF | 2.23263914 |
| 11 | LMTK2 | 2.07069044 |
| 12 | PIM2 | 2.03193636 |
| 13 | KDR | 2.02024736 |
| 14 | VRK1 | 1.93985964 |
| 15 | MST4 | 1.92890139 |
| 16 | MAP2K7 | 1.83332762 |
| 17 | SRPK1 | 1.80652716 |
| 18 | DAPK1 | 1.72304796 |
| 19 | TAF1 | 1.49253017 |
| 20 | CDK8 | 1.30385256 |
| 21 | CSNK1G3 | 1.27254272 |
| 22 | PAK4 | 1.26051682 |
| 23 | SCYL2 | 1.24140881 |
| 24 | TLK1 | 1.23241693 |
| 25 | ERN1 | 1.23101611 |
| 26 | NEK1 | 1.17870544 |
| 27 | CSNK1A1L | 1.17111108 |
| 28 | PBK | 1.15030702 |
| 29 | AURKA | 1.13837821 |
| 30 | CCNB1 | 1.07930390 |
| 31 | MAPKAPK3 | 1.02877942 |
| 32 | STK10 | 1.02458278 |
| 33 | ABL2 | 1.02074270 |
| 34 | PHKG2 | 1.00589548 |
| 35 | PHKG1 | 1.00589548 |
| 36 | WNK4 | 0.97088319 |
| 37 | TAOK2 | 0.94428969 |
| 38 | CSNK1G1 | 0.88977668 |
| 39 | STK16 | 0.88871281 |
| 40 | ZAK | 0.88821450 |
| 41 | NUAK1 | 0.86367014 |
| 42 | ERBB4 | 0.84451815 |
| 43 | CDK19 | 0.83168428 |
| 44 | MAP4K2 | 0.80286301 |
| 45 | DAPK3 | 0.77895457 |
| 46 | TBK1 | 0.76776510 |
| 47 | MOS | 0.75799923 |
| 48 | RPS6KA5 | 0.74780643 |
| 49 | CSNK1G2 | 0.74501662 |
| 50 | IRAK3 | 0.74314108 |
| 51 | STK39 | 0.66515121 |
| 52 | MYLK | 0.65813502 |
| 53 | MET | 0.64644189 |
| 54 | BRAF | 0.63923746 |
| 55 | CDK7 | 0.63500206 |
| 56 | TIE1 | 0.63071184 |
| 57 | AURKB | 0.62831177 |
| 58 | PAK1 | 0.61241968 |
| 59 | PLK4 | 0.59928689 |
| 60 | EIF2AK3 | 0.57615046 |
| 61 | PTK2B | 0.57409927 |
| 62 | BCR | 0.54918436 |
| 63 | ILK | 0.54462170 |
| 64 | HIPK2 | 0.52060093 |
| 65 | MUSK | 0.51974545 |
| 66 | PLK1 | 0.51832246 |
| 67 | PRKCI | 0.51492600 |
| 68 | PTK2 | 0.49920106 |
| 69 | MAP3K12 | 0.49615579 |
| 70 | OXSR1 | 0.48428695 |
| 71 | NME1 | 0.48325204 |
| 72 | SIK3 | 0.44899472 |
| 73 | EIF2AK2 | 0.44605674 |
| 74 | BMPR2 | 0.44250322 |
| 75 | BRSK1 | 0.43902797 |
| 76 | EIF2AK1 | 0.38311046 |
| 77 | SMG1 | 0.38281742 |
| 78 | CSNK2A2 | 0.37885448 |
| 79 | CHEK2 | 0.37794313 |
| 80 | MAPKAPK5 | 0.37746049 |
| 81 | MAP3K11 | 0.37626494 |
| 82 | ERBB3 | 0.37298975 |
| 83 | GRK5 | 0.35991700 |
| 84 | PDK2 | 0.35847160 |
| 85 | IKBKB | 0.35086340 |
| 86 | GRK7 | 0.32023266 |
| 87 | CSNK2A1 | 0.29835381 |
| 88 | CDC7 | 0.29027366 |
| 89 | ATR | 0.29017046 |
| 90 | CDK14 | 0.28886322 |
| 91 | IKBKE | 0.27270933 |
| 92 | LRRK2 | 0.26948965 |
| 93 | CDK11A | 0.26098227 |
| 94 | MAP3K8 | 0.25430263 |
| 95 | CDK18 | 0.23593590 |
| 96 | MAPKAPK2 | 0.22852863 |
| 97 | CDK15 | 0.22570611 |
| 98 | RAF1 | 0.22395392 |
| 99 | TSSK6 | 0.20008860 |
| 100 | CDK9 | 0.19194880 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.90672092 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.49081695 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.98526795 |
| 4 | Base excision repair_Homo sapiens_hsa03410 | 2.60470876 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.54635150 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.53375275 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.45794525 |
| 8 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.43403687 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.33557352 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.28214830 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.25313557 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.19818253 |
| 13 | Sulfur relay system_Homo sapiens_hsa04122 | 2.01691598 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.91171527 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.81606802 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.70280604 |
| 17 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.68077729 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.66688305 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.60554442 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.53626775 |
| 21 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.53215383 |
| 22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.53041214 |
| 23 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.51277497 |
| 24 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.50661504 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.49870216 |
| 26 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.46040847 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.42249887 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.38973963 |
| 29 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.38714446 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32057910 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.29002495 |
| 32 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.25969804 |
| 33 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.24564617 |
| 34 | Purine metabolism_Homo sapiens_hsa00230 | 1.24275705 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.23918557 |
| 36 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.21487060 |
| 37 | Galactose metabolism_Homo sapiens_hsa00052 | 1.20382936 |
| 38 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.18729842 |
| 39 | Carbon metabolism_Homo sapiens_hsa01200 | 1.17769301 |
| 40 | Viral myocarditis_Homo sapiens_hsa05416 | 1.16368470 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.15696301 |
| 42 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.15068398 |
| 43 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.11801182 |
| 44 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.10655461 |
| 45 | Allograft rejection_Homo sapiens_hsa05330 | 1.07439453 |
| 46 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.02211303 |
| 47 | Asthma_Homo sapiens_hsa05310 | 1.01286436 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.00938537 |
| 49 | RNA degradation_Homo sapiens_hsa03018 | 0.98738434 |
| 50 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.95489413 |
| 51 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.93083526 |
| 52 | Basal transcription factors_Homo sapiens_hsa03022 | 0.92678274 |
| 53 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.88088649 |
| 54 | Protein export_Homo sapiens_hsa03060 | 0.87733533 |
| 55 | Shigellosis_Homo sapiens_hsa05131 | 0.86204305 |
| 56 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.86028490 |
| 57 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.85281107 |
| 58 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.82831422 |
| 59 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.79047381 |
| 60 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.77864706 |
| 61 | Alcoholism_Homo sapiens_hsa05034 | 0.76515331 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.76130566 |
| 63 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.75361207 |
| 64 | Salivary secretion_Homo sapiens_hsa04970 | 0.75247566 |
| 65 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.75216808 |
| 66 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.73779608 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69838653 |
| 68 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.67350588 |
| 69 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.66484138 |
| 70 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65200228 |
| 71 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.65090769 |
| 72 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.64612486 |
| 73 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.63287334 |
| 74 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.62991425 |
| 75 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.62879494 |
| 76 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.59619304 |
| 77 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58682652 |
| 78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.57544262 |
| 79 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.56000379 |
| 80 | Cell cycle_Homo sapiens_hsa04110 | 0.55534354 |
| 81 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.51583351 |
| 82 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.50057443 |
| 83 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.49608108 |
| 84 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.47325089 |
| 85 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.45414650 |
| 86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43698402 |
| 87 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.43227307 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.42472371 |
| 89 | Peroxisome_Homo sapiens_hsa04146 | 0.41421994 |
| 90 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.39695420 |
| 91 | Apoptosis_Homo sapiens_hsa04210 | 0.37755376 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36039880 |
| 93 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34469276 |
| 94 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33947872 |
| 95 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.31431767 |
| 96 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.31075725 |
| 97 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.28659794 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.28633862 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.28623364 |
| 100 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.25696371 |

