PPIAP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)8.15484592
2cell wall macromolecule metabolic process (GO:0044036)6.76094691
3positive regulation of synaptic transmission, GABAergic (GO:0032230)6.28419629
4negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.60839671
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.50598126
6DNA deamination (GO:0045006)5.28401117
7CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.22891166
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.09661834
9ATP synthesis coupled proton transport (GO:0015986)5.09661834
10neurofilament cytoskeleton organization (GO:0060052)4.76301355
11neurotransmitter catabolic process (GO:0042135)4.44506943
12protein complex biogenesis (GO:0070271)4.18502051
13retinal cone cell development (GO:0046549)4.17417680
14cytidine metabolic process (GO:0046087)4.16786254
15cytidine catabolic process (GO:0006216)4.16786254
16cytidine deamination (GO:0009972)4.16786254
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.13690900
18cullin deneddylation (GO:0010388)4.09912669
19DNA strand renaturation (GO:0000733)4.07907411
20behavioral response to nicotine (GO:0035095)4.07352270
21anterograde axon cargo transport (GO:0008089)4.03064413
22mitochondrial respiratory chain complex assembly (GO:0033108)4.02990934
23synaptic transmission, cholinergic (GO:0007271)4.00749925
24positive regulation of amino acid transport (GO:0051957)3.97952537
25chaperone-mediated protein transport (GO:0072321)3.92397568
26somite development (GO:0061053)3.89685624
27protein localization to kinetochore (GO:0034501)3.83410182
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.81761352
29protein deneddylation (GO:0000338)3.81620434
30retinal ganglion cell axon guidance (GO:0031290)3.78854120
31interferon-gamma production (GO:0032609)3.74911929
32signal peptide processing (GO:0006465)3.72200090
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.67206104
34termination of RNA polymerase III transcription (GO:0006386)3.67206104
35adaptation of signaling pathway (GO:0023058)3.66728118
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65738705
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.65738705
38NADH dehydrogenase complex assembly (GO:0010257)3.65738705
39replication fork processing (GO:0031297)3.62532678
40proteasome assembly (GO:0043248)3.54340953
41intermediate filament organization (GO:0045109)3.53593202
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.47541346
43respiratory electron transport chain (GO:0022904)3.41250354
44activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.40966106
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39021279
46T cell lineage commitment (GO:0002360)3.37655271
47pyrimidine ribonucleoside catabolic process (GO:0046133)3.37188579
48regulation of chronic inflammatory response (GO:0002676)3.34599429
49platelet dense granule organization (GO:0060155)3.33549856
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33034273
51electron transport chain (GO:0022900)3.31795329
52negative regulation of DNA recombination (GO:0045910)3.18007196
53lipopolysaccharide metabolic process (GO:0008653)3.17706961
54alkaloid metabolic process (GO:0009820)3.04529866
55hydrogen ion transmembrane transport (GO:1902600)3.03628246
56regulation of mesoderm development (GO:2000380)3.02061061
57anterograde synaptic vesicle transport (GO:0048490)3.01514308
58lymphoid progenitor cell differentiation (GO:0002320)3.01342820
59GPI anchor biosynthetic process (GO:0006506)2.95271966
60histone H2A monoubiquitination (GO:0035518)2.94512973
61gamma-aminobutyric acid transport (GO:0015812)2.93909860
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91146727
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91146727
64isotype switching (GO:0045190)2.91146727
65negative regulation of alpha-beta T cell differentiation (GO:0046639)2.90353656
66negative regulation of multicellular organism growth (GO:0040015)2.89313657
67protein-cofactor linkage (GO:0018065)2.86980477
68GPI anchor metabolic process (GO:0006505)2.85888348
69pyrimidine nucleobase catabolic process (GO:0006208)2.83264600
70ATP biosynthetic process (GO:0006754)2.80073515
71oxidative phosphorylation (GO:0006119)2.78117685
72negative regulation of systemic arterial blood pressure (GO:0003085)2.74453389
73proton transport (GO:0015992)2.73616859
74postsynaptic membrane organization (GO:0001941)2.69561972
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69268357
76positive regulation of organic acid transport (GO:0032892)2.67038433
77hydrogen transport (GO:0006818)2.64703829
78indole-containing compound catabolic process (GO:0042436)2.64618923
79indolalkylamine catabolic process (GO:0046218)2.64618923
80tryptophan catabolic process (GO:0006569)2.64618923
81myoblast migration (GO:0051451)2.62136314
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60713997
83cellular biogenic amine catabolic process (GO:0042402)2.60357775
84amine catabolic process (GO:0009310)2.60357775
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58951627
86spliceosomal complex assembly (GO:0000245)2.58565693
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58182319
88negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.57499620
89regulation of mitochondrial translation (GO:0070129)2.57474450
90maturation of SSU-rRNA (GO:0030490)2.57043675
91regulation of isotype switching to IgG isotypes (GO:0048302)2.54599135
92positive regulation of fatty acid beta-oxidation (GO:0032000)2.53577850
93protein heterotetramerization (GO:0051290)2.51633531
94lysine catabolic process (GO:0006554)2.50813650
95lysine metabolic process (GO:0006553)2.50813650
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49491309
97negative regulation of T-helper cell differentiation (GO:0045623)2.49491309
98ubiquinone metabolic process (GO:0006743)2.49081891
99neurotransmitter metabolic process (GO:0042133)2.46369897
100negative regulation of B cell apoptotic process (GO:0002903)2.46003386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.54122264
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.72243546
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.22455005
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05247810
5VDR_22108803_ChIP-Seq_LS180_Human3.56040021
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.38463735
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26416823
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.77623869
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43101793
10IRF1_19129219_ChIP-ChIP_H3396_Human2.42325547
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37700281
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.22693029
13TAF15_26573619_Chip-Seq_HEK293_Human2.19724183
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16791028
15GBX2_23144817_ChIP-Seq_PC3_Human2.08023132
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04143770
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.00252180
18IGF1R_20145208_ChIP-Seq_DFB_Human1.97824646
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97111240
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91281072
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88073513
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.84885740
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81413370
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81101388
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.78746642
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.74849673
27HTT_18923047_ChIP-ChIP_STHdh_Human1.74362296
28ELK1_19687146_ChIP-ChIP_HELA_Human1.72729316
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70130686
30VDR_23849224_ChIP-Seq_CD4+_Human1.64900315
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62969203
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62962000
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62530091
34ELK1_22589737_ChIP-Seq_MCF10A_Human1.61996024
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58756837
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.57236243
37FUS_26573619_Chip-Seq_HEK293_Human1.50420999
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49439828
39ZNF274_21170338_ChIP-Seq_K562_Hela1.49170257
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49025034
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48171276
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.47899418
43EZH2_22144423_ChIP-Seq_EOC_Human1.45963841
44EWS_26573619_Chip-Seq_HEK293_Human1.45708617
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44657823
46BCAT_22108803_ChIP-Seq_LS180_Human1.44499124
47P300_19829295_ChIP-Seq_ESCs_Human1.40241117
48FOXP3_21729870_ChIP-Seq_TREG_Human1.38872659
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37960142
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32732183
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31637046
52MYC_18940864_ChIP-ChIP_HL60_Human1.27982607
53ER_23166858_ChIP-Seq_MCF-7_Human1.19516860
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17849059
55TCF4_22108803_ChIP-Seq_LS180_Human1.17551920
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17163612
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16591251
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13530196
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13471708
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.08727709
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.08518337
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07066838
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06715957
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05990381
65AR_21572438_ChIP-Seq_LNCaP_Human1.05888366
66TP53_22573176_ChIP-Seq_HFKS_Human1.05738471
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.03928113
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03214628
69DCP1A_22483619_ChIP-Seq_HELA_Human1.03018989
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.01957747
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01636063
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01448537
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00227137
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00177672
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99844366
76NANOG_19829295_ChIP-Seq_ESCs_Human0.99512889
77SOX2_19829295_ChIP-Seq_ESCs_Human0.99512889
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98468487
79THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98391683
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98291391
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96821901
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96472268
83AR_20517297_ChIP-Seq_VCAP_Human0.96130296
84STAT3_18555785_Chip-Seq_ESCs_Mouse0.95362982
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95229730
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.95229730
87TAL1_26923725_Chip-Seq_HPCs_Mouse0.94461824
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94005524
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92426473
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92426473
91SMAD4_21799915_ChIP-Seq_A2780_Human0.92162212
92TTF2_22483619_ChIP-Seq_HELA_Human0.92134848
93ERG_20517297_ChIP-Seq_VCAP_Human0.91426910
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89883053
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88417667
96P53_21459846_ChIP-Seq_SAOS-2_Human0.88145809
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86295815
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86272779
99P300_18555785_Chip-Seq_ESCs_Mouse0.85395551
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83382660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex7.15590662
2MP0002234_abnormal_pharynx_morphology4.02921361
3MP0010386_abnormal_urinary_bladder3.41014473
4MP0002735_abnormal_chemical_nociception3.24581241
5MP0001853_heart_inflammation2.61345089
6MP0006082_CNS_inflammation2.44389069
7MP0009053_abnormal_anal_canal2.41360660
8MP0003136_yellow_coat_color2.34933496
9MP0002102_abnormal_ear_morphology2.32217946
10MP0004147_increased_porphyrin_level2.31277559
11MP0005671_abnormal_response_to2.27716859
12MP0003283_abnormal_digestive_organ2.21525206
13MP0005551_abnormal_eye_electrophysiolog2.13466197
14MP0003011_delayed_dark_adaptation2.04617023
15MP0001873_stomach_inflammation1.95658957
16MP0000579_abnormal_nail_morphology1.94599938
17MP0001502_abnormal_circadian_rhythm1.87553314
18MP0002272_abnormal_nervous_system1.86423771
19MP0008058_abnormal_DNA_repair1.85278604
20MP0002736_abnormal_nociception_after1.80044477
21MP0005075_abnormal_melanosome_morpholog1.78786649
22MP0004381_abnormal_hair_follicle1.78527901
23MP0003119_abnormal_digestive_system1.78261614
24MP0001984_abnormal_olfaction1.76795244
25MP0000383_abnormal_hair_follicle1.74624299
26MP0003786_premature_aging1.73990689
27MP0001348_abnormal_lacrimal_gland1.72259657
28MP0008789_abnormal_olfactory_epithelium1.71026491
29MP0004510_myositis1.69254099
30MP0000538_abnormal_urinary_bladder1.60515283
31MP0001293_anophthalmia1.60128646
32MP0008875_abnormal_xenobiotic_pharmacok1.57479633
33MP0004142_abnormal_muscle_tone1.57199420
34MP0001970_abnormal_pain_threshold1.51071676
35MP0000013_abnormal_adipose_tissue1.50842284
36MP0005423_abnormal_somatic_nervous1.43392758
37MP0002163_abnormal_gland_morphology1.38934465
38MP0005253_abnormal_eye_physiology1.36872469
39MP0009745_abnormal_behavioral_response1.35985144
40MP0003718_maternal_effect1.35495119
41MP0009765_abnormal_xenobiotic_induced1.29117834
42MP0005197_abnormal_uvea_morphology1.28951966
43MP0001968_abnormal_touch/_nociception1.25881706
44MP0003880_abnormal_central_pattern1.25614040
45MP0008872_abnormal_physiological_respon1.19808683
46MP0000372_irregular_coat_pigmentation1.19392506
47MP0005394_taste/olfaction_phenotype1.18909514
48MP0005499_abnormal_olfactory_system1.18909514
49MP0002095_abnormal_skin_pigmentation1.08692646
50MP0002138_abnormal_hepatobiliary_system1.08343101
51MP0003567_abnormal_fetal_cardiomyocyte1.07378287
52MP0005310_abnormal_salivary_gland1.06831626
53MP0002090_abnormal_vision1.06250092
54MP0002733_abnormal_thermal_nociception1.04977508
55MP0010094_abnormal_chromosome_stability1.04383813
56MP0002751_abnormal_autonomic_nervous1.04224823
57MP0001986_abnormal_taste_sensitivity1.03480829
58MP0001835_abnormal_antigen_presentation1.01596152
59MP0006036_abnormal_mitochondrial_physio1.00591878
60MP0003942_abnormal_urinary_system1.00264525
61MP0006072_abnormal_retinal_apoptosis0.99848244
62MP0000647_abnormal_sebaceous_gland0.99561922
63MP0006292_abnormal_olfactory_placode0.96717246
64MP0003385_abnormal_body_wall0.95563319
65MP0008873_increased_physiological_sensi0.94900821
66MP0003635_abnormal_synaptic_transmissio0.93053542
67MP0002233_abnormal_nose_morphology0.92706344
68MP0005084_abnormal_gallbladder_morpholo0.89497604
69MP0001756_abnormal_urination0.89462948
70MP0002277_abnormal_respiratory_mucosa0.88557778
71MP0001661_extended_life_span0.86795317
72MP0000685_abnormal_immune_system0.84327510
73MP0005195_abnormal_posterior_eye0.83218250
74MP0005645_abnormal_hypothalamus_physiol0.80800950
75MP0002752_abnormal_somatic_nervous0.79659723
76MP0001324_abnormal_eye_pigmentation0.79431749
77MP0001800_abnormal_humoral_immune0.76631830
78MP0006035_abnormal_mitochondrial_morpho0.75108326
79MP0002064_seizures0.73543560
80MP0010678_abnormal_skin_adnexa0.73255498
81MP0001905_abnormal_dopamine_level0.71428672
82MP0000537_abnormal_urethra_morphology0.69418499
83MP0005391_vision/eye_phenotype0.68047110
84MP0008775_abnormal_heart_ventricle0.67158666
85MP0004859_abnormal_synaptic_plasticity0.66881524
86MP0002734_abnormal_mechanical_nocicepti0.65804876
87MP0004019_abnormal_vitamin_homeostasis0.65415758
88MP0002693_abnormal_pancreas_physiology0.64555473
89MP0008995_early_reproductive_senescence0.62548647
90MP0003787_abnormal_imprinting0.62407814
91MP0002177_abnormal_outer_ear0.60879201
92MP0003195_calcinosis0.60208653
93MP0009250_abnormal_appendicular_skeleto0.60031771
94MP0001764_abnormal_homeostasis0.60016655
95MP0000534_abnormal_ureter_morphology0.59987046
96MP0004134_abnormal_chest_morphology0.59927216
97MP0005000_abnormal_immune_tolerance0.59892111
98MP0005379_endocrine/exocrine_gland_phen0.59892023
99MP0000230_abnormal_systemic_arterial0.59128749
100MP0005174_abnormal_tail_pigmentation0.59089623

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)4.97010818
2Gait imbalance (HP:0002141)4.33661260
3Congenital primary aphakia (HP:0007707)4.10658166
4Medial flaring of the eyebrow (HP:0010747)4.04852442
5Nephrogenic diabetes insipidus (HP:0009806)3.88993241
6Acute necrotizing encephalopathy (HP:0006965)3.65490630
7Absent phalangeal crease (HP:0006109)3.47772354
8Abnormal mitochondria in muscle tissue (HP:0008316)3.46123093
9Congenital, generalized hypertrichosis (HP:0004540)3.39450982
10Vaginal atresia (HP:0000148)3.26032154
11Acute encephalopathy (HP:0006846)3.25579866
12Mitochondrial inheritance (HP:0001427)3.15429001
13Genital tract atresia (HP:0001827)3.10472825
14Abnormal finger flexion creases (HP:0006143)3.04759595
15Increased CSF lactate (HP:0002490)2.98449471
16Increased hepatocellular lipid droplets (HP:0006565)2.97633020
17IgG deficiency (HP:0004315)2.94664590
18Broad foot (HP:0001769)2.87541742
19Progressive macrocephaly (HP:0004481)2.84523537
20Abnormality of midbrain morphology (HP:0002418)2.80785204
21Molar tooth sign on MRI (HP:0002419)2.80785204
22Abnormal rod and cone electroretinograms (HP:0008323)2.78799218
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.78479756
24Segmental peripheral demyelination/remyelination (HP:0003481)2.72316653
25Abnormal number of incisors (HP:0011064)2.67304067
263-Methylglutaconic aciduria (HP:0003535)2.67037181
27Concave nail (HP:0001598)2.64663949
28Abnormality of the renal collecting system (HP:0004742)2.63131692
29Parakeratosis (HP:0001036)2.61205272
30Congenital stationary night blindness (HP:0007642)2.58993312
31Lipid accumulation in hepatocytes (HP:0006561)2.57379977
32Brittle hair (HP:0002299)2.55209772
33Follicular hyperkeratosis (HP:0007502)2.54573941
34Pendular nystagmus (HP:0012043)2.54279094
35Atonic seizures (HP:0010819)2.51586725
36Methylmalonic aciduria (HP:0012120)2.50630089
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.49279055
38Poor coordination (HP:0002370)2.49152361
39Large for gestational age (HP:0001520)2.47570619
40Hyperglycinemia (HP:0002154)2.46353223
41Pancreatic cysts (HP:0001737)2.44864976
42Duplicated collecting system (HP:0000081)2.44645919
43Neuroendocrine neoplasm (HP:0100634)2.44439787
44Pili torti (HP:0003777)2.43906305
45Increased intramyocellular lipid droplets (HP:0012240)2.41726901
46CNS hypomyelination (HP:0003429)2.40496443
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37312518
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37312518
49Status epilepticus (HP:0002133)2.36834978
50Bilateral microphthalmos (HP:0007633)2.31841787
51Conjunctival telangiectasia (HP:0000524)2.30877977
52Cerebral edema (HP:0002181)2.29915540
53Optic disc pallor (HP:0000543)2.26202119
54Abnormality of renal resorption (HP:0011038)2.24007487
55Diplopia (HP:0000651)2.22199495
56Abnormality of binocular vision (HP:0011514)2.22199495
57Renal Fanconi syndrome (HP:0001994)2.19460287
58Abnormal hair laboratory examination (HP:0003328)2.16859637
59Lethargy (HP:0001254)2.13465639
60Short 5th finger (HP:0009237)2.13271943
61Hepatocellular necrosis (HP:0001404)2.10035657
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.09948942
63Hypoplasia of the fovea (HP:0007750)2.09948942
64Increased serum lactate (HP:0002151)2.07122609
65Aplasia/Hypoplasia of the lens (HP:0008063)2.04247523
66Cerebral hypomyelination (HP:0006808)1.99320678
67Pheochromocytoma (HP:0002666)1.99305236
68Humeroradial synostosis (HP:0003041)1.99295715
69Synostosis involving the elbow (HP:0003938)1.99295715
70Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.97466717
71Maternal diabetes (HP:0009800)1.93256396
72Left ventricular hypertrophy (HP:0001712)1.91449234
73Hepatic necrosis (HP:0002605)1.90965978
74Methylmalonic acidemia (HP:0002912)1.90661398
75Increased muscle lipid content (HP:0009058)1.89231664
76Septo-optic dysplasia (HP:0100842)1.89040507
77Lactic acidosis (HP:0003128)1.88204128
78Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86724625
79Exercise intolerance (HP:0003546)1.85825457
80Blindness (HP:0000618)1.85428826
81Nephrotic syndrome (HP:0000100)1.84832846
82Type I transferrin isoform profile (HP:0003642)1.83793105
83Sparse eyelashes (HP:0000653)1.80483139
84Leukodystrophy (HP:0002415)1.79169185
85Congenital ichthyosiform erythroderma (HP:0007431)1.79039287
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78724070
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78367591
88Severe combined immunodeficiency (HP:0004430)1.77667303
89Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77124043
90Dental crowding (HP:0000678)1.75693311
91Pancreatic fibrosis (HP:0100732)1.75375342
92Coronal craniosynostosis (HP:0004440)1.74999061
93Exertional dyspnea (HP:0002875)1.73918248
94Chronic hepatic failure (HP:0100626)1.73208542
95Specific learning disability (HP:0001328)1.73201610
96True hermaphroditism (HP:0010459)1.70849614
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.68642377
98Hyperglycinuria (HP:0003108)1.67784549
99Reduced antithrombin III activity (HP:0001976)1.67007959
100Nephronophthisis (HP:0000090)1.66901421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.17756872
2GRK73.76917964
3BMPR1B3.57538780
4ACVR1B3.29022947
5MOS2.93849373
6TIE12.64592840
7EIF2AK12.54723187
8PDK22.53259703
9TGFBR22.51564784
10MST42.31458324
11NME12.25477522
12VRK22.14812165
13PBK1.93809610
14GRK51.78404032
15VRK11.74739809
16MKNK21.73431049
17STK101.68791432
18EIF2AK21.64141349
19MARK11.55439736
20NUAK11.44418738
21MAP4K21.43863217
22GRK11.33754351
23BCKDK1.29661981
24SIK21.25008779
25NEK11.19960223
26MAPK131.19291990
27BCR1.18256029
28ADRBK21.17297743
29ADRBK11.16823000
30BUB11.15594205
31MKNK11.14733686
32DAPK11.04502162
33ITK1.03567137
34TGFBR11.02294518
35SRPK11.00715540
36DYRK20.94277434
37NTRK20.89522043
38AURKA0.84033589
39TLK10.83008949
40ARAF0.82037125
41MAP3K90.80408132
42WNK30.79771457
43NEK20.78565142
44CCNB10.77233605
45KDR0.74435182
46PRKCG0.72768644
47MAP3K40.72169697
48STK38L0.70973234
49PRKCE0.67631248
50PLK40.67544434
51ERBB40.67356094
52PIK3CA0.65680491
53ILK0.63017072
54IGF1R0.60211648
55PLK30.59668232
56EPHA40.59243316
57CSF1R0.57337350
58ERBB20.56027452
59PRKACB0.55901444
60CAMK2A0.55876900
61PIM20.55512462
62INSRR0.54617618
63TAF10.48849887
64DYRK1A0.45870098
65DYRK30.45515606
66TNIK0.44545437
67STK240.43465565
68IKBKB0.43251791
69PHKG20.42437123
70PHKG10.42437123
71CDK50.40968372
72FGFR10.40855070
73FRK0.39624508
74PRKCI0.39105472
75TAOK30.38561406
76CDK30.38026594
77MAPKAPK50.37669882
78PRKACA0.36559658
79RPS6KA40.36399977
80MAPK120.35847692
81RPS6KA50.35653144
82PIK3CG0.35115406
83INSR0.34897483
84TSSK60.34723026
85CSNK1G30.34400049
86PDK10.33678465
87ATM0.33218717
88PRKCH0.32746162
89EIF2AK30.32087729
90CDC70.31837209
91PRKCQ0.30932822
92WEE10.29417922
93TEC0.29378410
94CSNK2A20.29315147
95LYN0.27833633
96PAK30.27764685
97ZAK0.27190620
98PRKACG0.26883571
99CSNK2A10.26612088
100PRKDC0.26337041

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.67116324
2Proteasome_Homo sapiens_hsa030503.46124604
3RNA polymerase_Homo sapiens_hsa030203.16176910
4Parkinsons disease_Homo sapiens_hsa050123.06377392
5One carbon pool by folate_Homo sapiens_hsa006702.46418759
6Asthma_Homo sapiens_hsa053102.39466588
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.26312440
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25440295
9Huntingtons disease_Homo sapiens_hsa050162.17748382
10Nicotine addiction_Homo sapiens_hsa050332.15097126
11Ribosome_Homo sapiens_hsa030102.08553708
12Alzheimers disease_Homo sapiens_hsa050102.07198591
13Phototransduction_Homo sapiens_hsa047442.05288981
14Protein export_Homo sapiens_hsa030602.04708219
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95043527
16Pyruvate metabolism_Homo sapiens_hsa006201.94012234
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93648757
18Autoimmune thyroid disease_Homo sapiens_hsa053201.91280713
19Mismatch repair_Homo sapiens_hsa034301.90890425
20beta-Alanine metabolism_Homo sapiens_hsa004101.87031170
21Allograft rejection_Homo sapiens_hsa053301.80508447
22Selenocompound metabolism_Homo sapiens_hsa004501.74498079
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67433349
24Pyrimidine metabolism_Homo sapiens_hsa002401.59061190
25DNA replication_Homo sapiens_hsa030301.56568568
26Nucleotide excision repair_Homo sapiens_hsa034201.52436080
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49348096
28Tryptophan metabolism_Homo sapiens_hsa003801.48007501
29Homologous recombination_Homo sapiens_hsa034401.41635002
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40302121
31Glycerolipid metabolism_Homo sapiens_hsa005611.39693224
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37282614
33Histidine metabolism_Homo sapiens_hsa003401.34204903
34Cardiac muscle contraction_Homo sapiens_hsa042601.32213339
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27988577
36RNA degradation_Homo sapiens_hsa030181.27295450
37Antigen processing and presentation_Homo sapiens_hsa046121.22039686
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19211072
39Fanconi anemia pathway_Homo sapiens_hsa034601.11144790
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06440528
41Fatty acid biosynthesis_Homo sapiens_hsa000611.04771482
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01178473
43Chemical carcinogenesis_Homo sapiens_hsa052041.00753219
44Linoleic acid metabolism_Homo sapiens_hsa005910.97812314
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97806662
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94457952
47Peroxisome_Homo sapiens_hsa041460.94037011
48Glutamatergic synapse_Homo sapiens_hsa047240.93984980
49Graft-versus-host disease_Homo sapiens_hsa053320.93109977
50Purine metabolism_Homo sapiens_hsa002300.92844089
51GABAergic synapse_Homo sapiens_hsa047270.90451134
52Nitrogen metabolism_Homo sapiens_hsa009100.89188625
53Butanoate metabolism_Homo sapiens_hsa006500.85770531
54Rheumatoid arthritis_Homo sapiens_hsa053230.83903684
55Propanoate metabolism_Homo sapiens_hsa006400.79410430
56Arginine and proline metabolism_Homo sapiens_hsa003300.78122554
57Basal transcription factors_Homo sapiens_hsa030220.77520507
58Collecting duct acid secretion_Homo sapiens_hsa049660.76270298
59Type I diabetes mellitus_Homo sapiens_hsa049400.73511164
60Primary immunodeficiency_Homo sapiens_hsa053400.73157039
61Spliceosome_Homo sapiens_hsa030400.72602786
62Olfactory transduction_Homo sapiens_hsa047400.72036786
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70376781
64Morphine addiction_Homo sapiens_hsa050320.69958695
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.69375083
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67817531
67Sulfur metabolism_Homo sapiens_hsa009200.65160300
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65151707
69Taste transduction_Homo sapiens_hsa047420.63597636
70Fatty acid degradation_Homo sapiens_hsa000710.63275618
71Hedgehog signaling pathway_Homo sapiens_hsa043400.62105783
72Metabolic pathways_Homo sapiens_hsa011000.58504861
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58371153
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57134752
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49155587
76ABC transporters_Homo sapiens_hsa020100.48362624
77RNA transport_Homo sapiens_hsa030130.47244754
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.47147999
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47115867
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47096450
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46971570
82Renin-angiotensin system_Homo sapiens_hsa046140.44027311
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43579451
84Basal cell carcinoma_Homo sapiens_hsa052170.42040554
85Ether lipid metabolism_Homo sapiens_hsa005650.41880077
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37115492
87Ovarian steroidogenesis_Homo sapiens_hsa049130.36812705
88Mineral absorption_Homo sapiens_hsa049780.36708261
89Arachidonic acid metabolism_Homo sapiens_hsa005900.36401471
90Folate biosynthesis_Homo sapiens_hsa007900.36049861
91Staphylococcus aureus infection_Homo sapiens_hsa051500.35656578
92Base excision repair_Homo sapiens_hsa034100.34740465
93Circadian rhythm_Homo sapiens_hsa047100.34002379
94Serotonergic synapse_Homo sapiens_hsa047260.33623394
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33242055
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32915364
97Glutathione metabolism_Homo sapiens_hsa004800.31443006
98Caffeine metabolism_Homo sapiens_hsa002320.30084542
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28637663
100Retinol metabolism_Homo sapiens_hsa008300.28220779

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