PPIAP25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.96365808
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.81676951
3ATP synthesis coupled proton transport (GO:0015986)6.81676951
4sequestering of actin monomers (GO:0042989)5.27176701
5respiratory electron transport chain (GO:0022904)4.60840229
6electron transport chain (GO:0022900)4.53201667
7ribosomal small subunit assembly (GO:0000028)4.52503351
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50739048
9viral transcription (GO:0019083)4.02090836
10tryptophan catabolic process (GO:0006569)4.00426105
11indole-containing compound catabolic process (GO:0042436)4.00426105
12indolalkylamine catabolic process (GO:0046218)4.00426105
13kynurenine metabolic process (GO:0070189)3.98496585
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.97968398
15termination of RNA polymerase III transcription (GO:0006386)3.97968398
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.92356591
17maturation of SSU-rRNA (GO:0030490)3.82487794
18base-excision repair, AP site formation (GO:0006285)3.79391735
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78901963
20protein complex biogenesis (GO:0070271)3.78365077
21ribosomal large subunit biogenesis (GO:0042273)3.77723519
22translational termination (GO:0006415)3.73537505
23hydrogen ion transmembrane transport (GO:1902600)3.69584936
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.64740803
25NADH dehydrogenase complex assembly (GO:0010257)3.64740803
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64740803
27ATP biosynthetic process (GO:0006754)3.64503846
28spinal cord association neuron differentiation (GO:0021527)3.61952568
29translational elongation (GO:0006414)3.61861346
30negative regulation of mast cell activation (GO:0033004)3.59198876
31respiratory chain complex IV assembly (GO:0008535)3.59037107
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.57073804
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56425556
34cotranslational protein targeting to membrane (GO:0006613)3.50626763
35regulation of cellular amino acid metabolic process (GO:0006521)3.48747629
36mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.48708309
37positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.48708309
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.47525856
39platelet dense granule organization (GO:0060155)3.47215703
40mitochondrial respiratory chain complex assembly (GO:0033108)3.46419465
41protein targeting to ER (GO:0045047)3.40344678
42opioid receptor signaling pathway (GO:0038003)3.39631880
43proton transport (GO:0015992)3.38009332
44tryptophan metabolic process (GO:0006568)3.37577191
45chaperone-mediated protein transport (GO:0072321)3.33588790
46tachykinin receptor signaling pathway (GO:0007217)3.33022812
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29327555
48hydrogen transport (GO:0006818)3.28909382
49positive regulation of protein homodimerization activity (GO:0090073)3.28311560
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26897658
51histone H2A acetylation (GO:0043968)3.26671914
52purine deoxyribonucleotide catabolic process (GO:0009155)3.26554386
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26533273
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.26478638
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.26478638
56protein localization to endoplasmic reticulum (GO:0070972)3.25979792
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21154177
58negative regulation of ligase activity (GO:0051352)3.21154177
59inner mitochondrial membrane organization (GO:0007007)3.19341260
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17530257
61positive regulation of uterine smooth muscle contraction (GO:0070474)3.17522603
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16742574
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15663155
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14863397
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14863397
66regulation of cellular respiration (GO:0043457)3.12998735
67behavioral response to nicotine (GO:0035095)3.12884925
68DNA deamination (GO:0045006)3.11165200
69positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.11119847
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11080151
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11080151
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11080151
73indolalkylamine metabolic process (GO:0006586)3.08817233
74epithelial cilium movement (GO:0003351)3.03461277
75cytochrome complex assembly (GO:0017004)3.00932972
76cellular protein complex disassembly (GO:0043624)3.00545353
77protein neddylation (GO:0045116)2.99196547
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97786517
79xenobiotic catabolic process (GO:0042178)2.94530314
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.93395229
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.93395229
82mast cell activation (GO:0045576)2.92964045
83iron-sulfur cluster assembly (GO:0016226)2.91470186
84metallo-sulfur cluster assembly (GO:0031163)2.91470186
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.90736550
86positive regulation of neurotransmitter secretion (GO:0001956)2.87919220
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.87141007
88ribonucleoside triphosphate biosynthetic process (GO:0009201)2.86271603
89translation (GO:0006412)2.84890524
90mast cell activation involved in immune response (GO:0002279)2.84421755
91mast cell degranulation (GO:0043303)2.84421755
92dopamine transport (GO:0015872)2.83446140
93antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82934719
94regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.81167574
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80646718
96response to pheromone (GO:0019236)2.76443719
97amine catabolic process (GO:0009310)2.75931810
98cellular biogenic amine catabolic process (GO:0042402)2.75931810
99viral life cycle (GO:0019058)2.75849567
100deoxyribose phosphate catabolic process (GO:0046386)2.74998081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.55282784
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.11271553
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.98860116
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.89448518
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63015244
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.31225329
7EZH2_22144423_ChIP-Seq_EOC_Human3.19292564
8ZNF274_21170338_ChIP-Seq_K562_Hela3.12142850
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.00142686
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88440579
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.86770785
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84236150
13VDR_22108803_ChIP-Seq_LS180_Human2.83330176
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.81823271
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36759684
16VDR_23849224_ChIP-Seq_CD4+_Human2.32283986
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26099355
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09567854
19ELK1_19687146_ChIP-ChIP_HELA_Human2.06257031
20FOXP3_21729870_ChIP-Seq_TREG_Human1.78141762
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76002870
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.66292794
23YY1_21170310_ChIP-Seq_MESCs_Mouse1.60284100
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59136429
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54058428
26PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.44564659
27ELK1_22589737_ChIP-Seq_MCF10A_Human1.43582336
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.43279564
29IRF1_19129219_ChIP-ChIP_H3396_Human1.42999542
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41651974
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41614858
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.41227748
33AR_21572438_ChIP-Seq_LNCaP_Human1.40005312
34TP53_22573176_ChIP-Seq_HFKS_Human1.36855526
35DCP1A_22483619_ChIP-Seq_HELA_Human1.36068032
36MYC_18940864_ChIP-ChIP_HL60_Human1.34652613
37NCOR_22424771_ChIP-Seq_293T_Human1.32012853
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30366730
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29588924
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27302751
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24916427
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.23673366
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23643248
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21315915
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20807306
46TTF2_22483619_ChIP-Seq_HELA_Human1.20394087
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18739591
48FOXH1_21741376_ChIP-Seq_EPCs_Human1.17026774
49ERG_20517297_ChIP-Seq_VCAP_Human1.16728602
50XRN2_22483619_ChIP-Seq_HELA_Human1.16504955
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16156716
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15818439
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13809999
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11687257
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10924171
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.10924171
57TAF2_19829295_ChIP-Seq_ESCs_Human1.10913492
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10745272
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10481259
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09205625
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08953115
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08732652
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07677651
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07374242
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06690671
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.05395697
67AR_20517297_ChIP-Seq_VCAP_Human1.05155670
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04324972
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03027823
70NANOG_19829295_ChIP-Seq_ESCs_Human1.02786616
71SOX2_19829295_ChIP-Seq_ESCs_Human1.02786616
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02552530
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02308756
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.02000741
75EWS_26573619_Chip-Seq_HEK293_Human1.00012308
76FUS_26573619_Chip-Seq_HEK293_Human0.99826187
77MYC_19829295_ChIP-Seq_ESCs_Human0.99544214
78NANOG_20526341_ChIP-Seq_ESCs_Human0.99167958
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98864728
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98533783
81GABP_19822575_ChIP-Seq_HepG2_Human0.97765693
82THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96105131
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95855445
84P53_21459846_ChIP-Seq_SAOS-2_Human0.95816458
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95669547
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93819407
87GATA3_26560356_Chip-Seq_TH2_Human0.92786624
88FLI1_27457419_Chip-Seq_LIVER_Mouse0.91632106
89BCL6_27268052_Chip-Seq_Bcells_Human0.90870233
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90074752
91ERA_21632823_ChIP-Seq_H3396_Human0.88639888
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88552465
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87651122
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86762990
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86361161
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86120729
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85980183
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85824333
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84856702
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.84788292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.64828680
2MP0003011_delayed_dark_adaptation3.49152211
3MP0002822_catalepsy3.26884157
4MP0005671_abnormal_response_to2.63476335
5MP0005451_abnormal_body_composition2.61775336
6MP0004147_increased_porphyrin_level2.59083869
7MP0001873_stomach_inflammation2.53485059
8MP0005645_abnormal_hypothalamus_physiol2.42659124
9MP0008872_abnormal_physiological_respon2.34622995
10MP0004142_abnormal_muscle_tone2.28141030
11MP0001835_abnormal_antigen_presentation2.20529926
12MP0002653_abnormal_ependyma_morphology1.96017624
13MP0003880_abnormal_central_pattern1.91571504
14MP0008875_abnormal_xenobiotic_pharmacok1.91221824
15MP0008995_early_reproductive_senescence1.85486451
16MP0006036_abnormal_mitochondrial_physio1.85202937
17MP0001905_abnormal_dopamine_level1.83528953
18MP0004742_abnormal_vestibular_system1.81692514
19MP0001529_abnormal_vocalization1.76966143
20MP0006292_abnormal_olfactory_placode1.70588594
21MP0002102_abnormal_ear_morphology1.69765894
22MP0006072_abnormal_retinal_apoptosis1.65731092
23MP0009745_abnormal_behavioral_response1.65379373
24MP0005551_abnormal_eye_electrophysiolog1.57999362
25MP0002638_abnormal_pupillary_reflex1.55516031
26MP0010030_abnormal_orbit_morphology1.54000982
27MP0002736_abnormal_nociception_after1.52778138
28MP0005253_abnormal_eye_physiology1.49104125
29MP0001986_abnormal_taste_sensitivity1.39657079
30MP0009333_abnormal_splenocyte_physiolog1.39389656
31MP0006276_abnormal_autonomic_nervous1.39171327
32MP0003283_abnormal_digestive_organ1.32877208
33MP0000631_abnormal_neuroendocrine_gland1.31789948
34MP0002933_joint_inflammation1.31541318
35MP0010386_abnormal_urinary_bladder1.31064671
36MP0003763_abnormal_thymus_physiology1.28127857
37MP0001970_abnormal_pain_threshold1.26309231
38MP0003938_abnormal_ear_development1.25841691
39MP0003786_premature_aging1.24600017
40MP0002166_altered_tumor_susceptibility1.24528054
41MP0002163_abnormal_gland_morphology1.23946245
42MP0009785_altered_susceptibility_to1.23588501
43MP0003806_abnormal_nucleotide_metabolis1.21124407
44MP0003638_abnormal_response/metabolism_1.17974737
45MP0002272_abnormal_nervous_system1.17699365
46MP0005646_abnormal_pituitary_gland1.17060400
47MP0001968_abnormal_touch/_nociception1.13044927
48MP0000013_abnormal_adipose_tissue1.12418763
49MP0002735_abnormal_chemical_nociception1.12104985
50MP0008877_abnormal_DNA_methylation1.11483719
51MP0000049_abnormal_middle_ear1.01563667
52MP0002277_abnormal_respiratory_mucosa1.00978534
53MP0001800_abnormal_humoral_immune1.00930420
54MP0003122_maternal_imprinting0.98420354
55MP0001919_abnormal_reproductive_system0.96492567
56MP0002006_tumorigenesis0.95049688
57MP0002557_abnormal_social/conspecific_i0.94828888
58MP0000372_irregular_coat_pigmentation0.94776919
59MP0002572_abnormal_emotion/affect_behav0.94293144
60MP0003724_increased_susceptibility_to0.94211620
61MP0003315_abnormal_perineum_morphology0.93791161
62MP0004133_heterotaxia0.93021210
63MP0002938_white_spotting0.92476393
64MP0005084_abnormal_gallbladder_morpholo0.90907925
65MP0002067_abnormal_sensory_capabilities0.89772551
66MP0005257_abnormal_intraocular_pressure0.89363302
67MP0002405_respiratory_system_inflammati0.89124719
68MP0005379_endocrine/exocrine_gland_phen0.88675884
69MP0002249_abnormal_larynx_morphology0.88394035
70MP0006035_abnormal_mitochondrial_morpho0.87162712
71MP0001486_abnormal_startle_reflex0.86992370
72MP0003718_maternal_effect0.86789509
73MP0000647_abnormal_sebaceous_gland0.83413410
74MP0002282_abnormal_trachea_morphology0.82729915
75MP0001119_abnormal_female_reproductive0.82481074
76MP0001663_abnormal_digestive_system0.80406006
77MP0005000_abnormal_immune_tolerance0.80345872
78MP0005636_abnormal_mineral_homeostasis0.79899045
79MP0000026_abnormal_inner_ear0.79106117
80MP0005085_abnormal_gallbladder_physiolo0.78899444
81MP0000538_abnormal_urinary_bladder0.78664534
82MP0002723_abnormal_immune_serum0.77005783
83MP0002063_abnormal_learning/memory/cond0.76943502
84MP0002733_abnormal_thermal_nociception0.76104100
85MP0002210_abnormal_sex_determination0.73608251
86MP0009764_decreased_sensitivity_to0.73587584
87MP0005389_reproductive_system_phenotype0.73403181
88MP0002837_dystrophic_cardiac_calcinosis0.72988706
89MP0005381_digestive/alimentary_phenotyp0.72172187
90MP0003635_abnormal_synaptic_transmissio0.72093663
91MP0000653_abnormal_sex_gland0.72025527
92MP0001765_abnormal_ion_homeostasis0.71977146
93MP0008058_abnormal_DNA_repair0.70171383
94MP0001929_abnormal_gametogenesis0.69217064
95MP0001440_abnormal_grooming_behavior0.68528456
96MP0001764_abnormal_homeostasis0.68302953
97MP0002095_abnormal_skin_pigmentation0.67203165
98MP0001145_abnormal_male_reproductive0.67021500
99MP0009046_muscle_twitch0.66672164
100MP0005195_abnormal_posterior_eye0.66221137

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87172965
2Mitochondrial inheritance (HP:0001427)4.53633356
3Abnormal mitochondria in muscle tissue (HP:0008316)4.32706102
4Aplastic anemia (HP:0001915)4.28835272
5Colon cancer (HP:0003003)4.10087708
6Progressive macrocephaly (HP:0004481)4.09290944
7Increased CSF lactate (HP:0002490)3.96071994
8Hepatocellular necrosis (HP:0001404)3.81881653
9Abnormality of B cell number (HP:0010975)3.75389187
10Acute encephalopathy (HP:0006846)3.74166486
11Congenital stationary night blindness (HP:0007642)3.65365014
12Hepatic necrosis (HP:0002605)3.50162120
13Stomach cancer (HP:0012126)3.49217197
14Increased hepatocellular lipid droplets (HP:0006565)3.37878770
15Renal Fanconi syndrome (HP:0001994)3.10398343
16Septo-optic dysplasia (HP:0100842)3.01841671
17Abnormality of midbrain morphology (HP:0002418)2.95820710
18Molar tooth sign on MRI (HP:0002419)2.95820710
193-Methylglutaconic aciduria (HP:0003535)2.92188212
20Optic disc pallor (HP:0000543)2.92050614
21Lipid accumulation in hepatocytes (HP:0006561)2.83509083
22IgG deficiency (HP:0004315)2.83417563
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.79418847
24Cerebral edema (HP:0002181)2.76769769
25Retinal dysplasia (HP:0007973)2.68814038
26True hermaphroditism (HP:0010459)2.65350492
27Increased intramyocellular lipid droplets (HP:0012240)2.63904816
28Increased serum lactate (HP:0002151)2.63503076
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63232277
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63232277
31Sensory axonal neuropathy (HP:0003390)2.60716155
32Abolished electroretinogram (ERG) (HP:0000550)2.51092389
33Pancreatic fibrosis (HP:0100732)2.49330464
34Rough bone trabeculation (HP:0100670)2.46561320
35Exertional dyspnea (HP:0002875)2.44246378
36Pancreatic cysts (HP:0001737)2.42285692
37Autoimmune thrombocytopenia (HP:0001973)2.41499799
38Respiratory failure (HP:0002878)2.33661577
39Leukodystrophy (HP:0002415)2.33626462
40Constricted visual fields (HP:0001133)2.32773010
41Lactic acidosis (HP:0003128)2.30783390
42Increased IgM level (HP:0003496)2.30230363
43Abnormality of the prostate (HP:0008775)2.29360791
44Congenital, generalized hypertrichosis (HP:0004540)2.28731479
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27482524
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24100007
47Medial flaring of the eyebrow (HP:0010747)2.23879854
48Reticulocytopenia (HP:0001896)2.23671095
49Oral leukoplakia (HP:0002745)2.22500803
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21220645
51Generalized aminoaciduria (HP:0002909)2.19359771
52Type II lissencephaly (HP:0007260)2.16751072
53Pancytopenia (HP:0001876)2.15530621
54Attenuation of retinal blood vessels (HP:0007843)2.14673065
55Limb dystonia (HP:0002451)2.14467046
56Hypoplasia of the pons (HP:0012110)2.14432166
57Submucous cleft hard palate (HP:0000176)2.13758410
58B lymphocytopenia (HP:0010976)2.13223283
59Elevated erythrocyte sedimentation rate (HP:0003565)2.11905685
60Methylmalonic acidemia (HP:0002912)2.11375968
61Abnormal rod and cone electroretinograms (HP:0008323)2.07229572
62Testicular atrophy (HP:0000029)2.06790648
63Cerebellar dysplasia (HP:0007033)2.06496780
64Type 2 muscle fiber atrophy (HP:0003554)2.05886632
65Dyschromatopsia (HP:0007641)2.05557338
66Abnormality of the pons (HP:0007361)2.04566944
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02703313
68Pendular nystagmus (HP:0012043)2.00442688
69Abnormal delayed hypersensitivity skin test (HP:0002963)1.99757833
70Optic nerve hypoplasia (HP:0000609)1.99151822
71Stenosis of the external auditory canal (HP:0000402)1.98613000
72Macrocytic anemia (HP:0001972)1.98144384
73Abnormality of T cell number (HP:0011839)1.96210698
74Lethargy (HP:0001254)1.96207529
75Increased muscle lipid content (HP:0009058)1.96188823
76Autoimmune hemolytic anemia (HP:0001890)1.94868527
77Absent septum pellucidum (HP:0001331)1.91196032
78Rib fusion (HP:0000902)1.91185575
79Abnormality of eosinophils (HP:0001879)1.88371119
80Exercise intolerance (HP:0003546)1.87680519
81Microretrognathia (HP:0000308)1.86507776
82Sclerocornea (HP:0000647)1.84678578
83Abnormality of renal resorption (HP:0011038)1.84437848
84Abnormality of the labia minora (HP:0012880)1.83377931
85Abnormal trabecular bone morphology (HP:0100671)1.83025745
86Parakeratosis (HP:0001036)1.79147705
87Anencephaly (HP:0002323)1.78615523
88Methylmalonic aciduria (HP:0012120)1.77830158
89Decreased central vision (HP:0007663)1.76332925
90Congenital ichthyosiform erythroderma (HP:0007431)1.76299726
91Abnormality of cells of the erythroid lineage (HP:0012130)1.75521456
92Severe visual impairment (HP:0001141)1.70356425
93Metabolic alkalosis (HP:0200114)1.69892885
94Flat capital femoral epiphysis (HP:0003370)1.69703355
95Myokymia (HP:0002411)1.69244399
96Increased corneal curvature (HP:0100692)1.68373432
97Keratoconus (HP:0000563)1.68373432
98Choroideremia (HP:0001139)1.66925689
99Severe combined immunodeficiency (HP:0004430)1.66190277
100Increased serum pyruvate (HP:0003542)1.65525961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.77619006
2CDK193.70949464
3VRK23.19751701
4MAP4K22.86542820
5CAMKK22.73107297
6NUAK12.71507746
7PINK12.56228489
8TAOK32.29568385
9MAP3K122.25315983
10PASK2.20295343
11BCKDK2.18587925
12STK162.16394734
13TESK21.81459936
14BUB11.78747565
15KDR1.78462256
16CDC71.73520254
17TLK11.69431323
18KIT1.65141477
19ERBB31.64774077
20CDK81.57999277
21NME11.46142942
22CSF1R1.45638462
23VRK11.45054375
24CAMKK11.41232207
25LIMK11.40045886
26DYRK21.40028725
27WNK31.19167830
28TXK1.18880717
29FLT31.17395825
30MAP2K71.15897405
31MAP3K41.15868152
32PRKD31.15030912
33MYLK1.14096975
34MST41.09937733
35GRK11.09030787
36TESK11.06642700
37CCNB11.01185063
38DAPK30.99961745
39BMPR20.97510307
40EPHA40.94417117
41PLK40.92313754
42ZAK0.91888969
43MAPK130.88427435
44NTRK20.87100019
45TEC0.84802657
46ILK0.84400075
47PIK3CG0.81343936
48SRPK10.80345731
49BRSK10.76460279
50SCYL20.74689666
51SIK20.72958225
52TAOK20.67180533
53NME20.66567195
54TAF10.66509328
55SIK30.66327162
56ABL20.65444972
57PIM20.64269784
58DAPK10.64107885
59CSNK1G30.62682887
60INSRR0.61432570
61GRK50.60955157
62ITK0.60214791
63LATS10.57890031
64TRIM280.56477886
65GRK70.55995327
66CLK10.55772531
67SYK0.55286632
68CSNK1G10.54774263
69LRRK20.54208329
70NEK10.53796224
71EPHB20.53581266
72CSNK1G20.52279674
73BRSK20.51851736
74TSSK60.50483072
75PKN10.50391539
76STK38L0.50345572
77OXSR10.49496061
78PLK20.49078588
79PRKCG0.48001537
80OBSCN0.47907757
81PBK0.47775475
82PLK30.46982745
83PHKG10.45973701
84PHKG20.45973701
85PRKCI0.44715337
86MARK10.44420909
87PRKACA0.44002650
88TIE10.43106450
89LCK0.42332162
90RPS6KA50.42059106
91PRKG10.40548585
92LYN0.38333289
93GRK60.37889076
94CDK11A0.36249954
95PRKCE0.35486480
96WNK40.35196154
97MAP3K110.35162106
98IGF1R0.35115713
99CSNK2A10.34981689
100AURKB0.34852204

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.07863108
2Proteasome_Homo sapiens_hsa030504.03926641
3Ribosome_Homo sapiens_hsa030103.63334329
4Asthma_Homo sapiens_hsa053103.44800857
5Parkinsons disease_Homo sapiens_hsa050123.42994055
6RNA polymerase_Homo sapiens_hsa030202.67542326
7Allograft rejection_Homo sapiens_hsa053302.41924547
8Graft-versus-host disease_Homo sapiens_hsa053322.40400457
9Autoimmune thyroid disease_Homo sapiens_hsa053202.35491962
10Alzheimers disease_Homo sapiens_hsa050102.23294474
11Huntingtons disease_Homo sapiens_hsa050162.12544091
12Type I diabetes mellitus_Homo sapiens_hsa049402.09993422
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06818290
14Protein export_Homo sapiens_hsa030602.02252318
15Homologous recombination_Homo sapiens_hsa034401.97948184
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96967725
17Antigen processing and presentation_Homo sapiens_hsa046121.91787162
18Primary immunodeficiency_Homo sapiens_hsa053401.84135097
19One carbon pool by folate_Homo sapiens_hsa006701.83275706
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79668757
21Cardiac muscle contraction_Homo sapiens_hsa042601.70574888
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67397963
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63535432
24Mismatch repair_Homo sapiens_hsa034301.60976402
25Base excision repair_Homo sapiens_hsa034101.56211401
26Nitrogen metabolism_Homo sapiens_hsa009101.50307835
27Rheumatoid arthritis_Homo sapiens_hsa053231.50283495
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49709209
29Caffeine metabolism_Homo sapiens_hsa002321.37489479
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26030818
31Fanconi anemia pathway_Homo sapiens_hsa034601.24082996
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20668609
33Viral myocarditis_Homo sapiens_hsa054161.19184568
34DNA replication_Homo sapiens_hsa030301.16387032
35RNA degradation_Homo sapiens_hsa030181.11747591
36Collecting duct acid secretion_Homo sapiens_hsa049661.11446184
37Pyrimidine metabolism_Homo sapiens_hsa002401.05021362
38Tryptophan metabolism_Homo sapiens_hsa003801.04130899
39Olfactory transduction_Homo sapiens_hsa047401.01425088
40Steroid biosynthesis_Homo sapiens_hsa001000.99460913
41Hedgehog signaling pathway_Homo sapiens_hsa043400.94235886
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87124229
43Butanoate metabolism_Homo sapiens_hsa006500.84522575
44Staphylococcus aureus infection_Homo sapiens_hsa051500.82552491
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82395812
46Phototransduction_Homo sapiens_hsa047440.82321970
47Systemic lupus erythematosus_Homo sapiens_hsa053220.80642387
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78986523
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78112707
50Nicotine addiction_Homo sapiens_hsa050330.77832665
51Glutathione metabolism_Homo sapiens_hsa004800.77103992
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76001433
53Purine metabolism_Homo sapiens_hsa002300.75941943
54Hematopoietic cell lineage_Homo sapiens_hsa046400.74695239
55Peroxisome_Homo sapiens_hsa041460.72880529
56Spliceosome_Homo sapiens_hsa030400.72188799
57Basal cell carcinoma_Homo sapiens_hsa052170.72048894
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71397774
59Linoleic acid metabolism_Homo sapiens_hsa005910.71281764
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67506099
61Chemical carcinogenesis_Homo sapiens_hsa052040.66105830
62Retinol metabolism_Homo sapiens_hsa008300.62579185
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61176624
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60172777
65Metabolic pathways_Homo sapiens_hsa011000.57768775
66Pyruvate metabolism_Homo sapiens_hsa006200.57732698
67Sulfur relay system_Homo sapiens_hsa041220.56453065
68Nucleotide excision repair_Homo sapiens_hsa034200.56230751
69Synaptic vesicle cycle_Homo sapiens_hsa047210.52739786
70RNA transport_Homo sapiens_hsa030130.52298660
71Salivary secretion_Homo sapiens_hsa049700.51811541
72Regulation of autophagy_Homo sapiens_hsa041400.51343930
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.51064877
74Leishmaniasis_Homo sapiens_hsa051400.50726553
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.48260881
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47744389
77Arachidonic acid metabolism_Homo sapiens_hsa005900.46817217
78Taste transduction_Homo sapiens_hsa047420.42410321
79Morphine addiction_Homo sapiens_hsa050320.42169482
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39872529
81Selenocompound metabolism_Homo sapiens_hsa004500.39491577
82Non-homologous end-joining_Homo sapiens_hsa034500.39269299
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.37366648
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.35660453
85Propanoate metabolism_Homo sapiens_hsa006400.35588498
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35410349
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34040537
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33499528
89Epstein-Barr virus infection_Homo sapiens_hsa051690.29098307
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27967473
91Circadian rhythm_Homo sapiens_hsa047100.27012747
92Fatty acid elongation_Homo sapiens_hsa000620.26434738
93GABAergic synapse_Homo sapiens_hsa047270.26431430
94Vibrio cholerae infection_Homo sapiens_hsa051100.23674229
95Phagosome_Homo sapiens_hsa041450.23625730
96Fatty acid degradation_Homo sapiens_hsa000710.23600294
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22745753
98Basal transcription factors_Homo sapiens_hsa030220.21152076
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21056447
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20130240

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