PPIAP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.53084358
2base-excision repair, AP site formation (GO:0006285)5.55834316
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.49065241
4rRNA modification (GO:0000154)5.32624048
5purine deoxyribonucleotide catabolic process (GO:0009155)5.23662272
6sequestering of actin monomers (GO:0042989)4.91847793
7ATP synthesis coupled proton transport (GO:0015986)4.61474267
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.61474267
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.43842491
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.40536360
11cytidine metabolic process (GO:0046087)4.38601191
12cytidine catabolic process (GO:0006216)4.38601191
13cytidine deamination (GO:0009972)4.38601191
14proteasome assembly (GO:0043248)4.12002438
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.98172600
16exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.93283851
17ubiquinone biosynthetic process (GO:0006744)3.91679523
18deoxyribonucleotide catabolic process (GO:0009264)3.89268081
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.79489792
20termination of RNA polymerase III transcription (GO:0006386)3.79489792
21pseudouridine synthesis (GO:0001522)3.79333348
22rRNA methylation (GO:0031167)3.76136410
23xenobiotic catabolic process (GO:0042178)3.73798816
24platelet dense granule organization (GO:0060155)3.69215610
25respiratory electron transport chain (GO:0022904)3.66234242
26deoxyribose phosphate catabolic process (GO:0046386)3.64808325
27cullin deneddylation (GO:0010388)3.63650692
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59799397
29electron transport chain (GO:0022900)3.59088527
30DNA replication-dependent nucleosome assembly (GO:0006335)3.56417824
31DNA replication-dependent nucleosome organization (GO:0034723)3.56417824
32ubiquinone metabolic process (GO:0006743)3.51001741
33pyrimidine ribonucleoside catabolic process (GO:0046133)3.50303935
34protein deneddylation (GO:0000338)3.43264608
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.39332242
36GTP biosynthetic process (GO:0006183)3.36657987
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33821485
38nucleobase biosynthetic process (GO:0046112)3.31270867
39maturation of SSU-rRNA (GO:0030490)3.30413187
40chaperone-mediated protein transport (GO:0072321)3.30198479
41kynurenine metabolic process (GO:0070189)3.26607159
42ribosome assembly (GO:0042255)3.21974292
43maturation of 5.8S rRNA (GO:0000460)3.20921283
44ribosome biogenesis (GO:0042254)3.18857285
45intracellular protein transmembrane import (GO:0044743)3.18808792
46DNA catabolic process, exonucleolytic (GO:0000738)3.17483917
47quinone biosynthetic process (GO:1901663)3.13508972
48NADH metabolic process (GO:0006734)3.13160880
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12641797
50spliceosomal snRNP assembly (GO:0000387)3.12623410
51purine deoxyribonucleotide metabolic process (GO:0009151)3.10675184
52protein targeting to mitochondrion (GO:0006626)3.10496271
53transcription from mitochondrial promoter (GO:0006390)3.10457795
54regulation of cellular amino acid metabolic process (GO:0006521)3.09613977
55DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07568522
56protein neddylation (GO:0045116)3.06385007
57ribosomal small subunit assembly (GO:0000028)3.04345238
58UTP biosynthetic process (GO:0006228)3.00075173
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97751624
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97751624
61establishment of protein localization to mitochondrion (GO:0072655)2.97535712
62negative regulation of calcium ion transport into cytosol (GO:0010523)2.96029433
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93472505
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93472505
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93472505
66deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.93471876
67water-soluble vitamin biosynthetic process (GO:0042364)2.93343269
68ribosomal large subunit biogenesis (GO:0042273)2.92952185
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91357612
70pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.90755168
71negative regulation of mast cell activation (GO:0033004)2.89729006
72ribonucleoprotein complex biogenesis (GO:0022613)2.88496390
73regulation of cellular respiration (GO:0043457)2.87767658
74regulation of interleukin-1 beta secretion (GO:0050706)2.87560476
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87091354
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87091354
77termination of RNA polymerase I transcription (GO:0006363)2.87056717
78protein complex biogenesis (GO:0070271)2.81714674
79signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81101341
80signal transduction involved in DNA damage checkpoint (GO:0072422)2.81101341
81negative regulation of ligase activity (GO:0051352)2.81085519
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81085519
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80862580
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80754629
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80721820
86CENP-A containing nucleosome assembly (GO:0034080)2.79184709
87positive regulation of interleukin-1 beta secretion (GO:0050718)2.78977170
88purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.78294958
89signal transduction involved in cell cycle checkpoint (GO:0072395)2.77997182
902-deoxyribonucleotide metabolic process (GO:0009394)2.77385287
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77142206
92telomere maintenance via semi-conservative replication (GO:0032201)2.76659118
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75856366
94chromatin remodeling at centromere (GO:0031055)2.74573570
95DNA strand elongation involved in DNA replication (GO:0006271)2.73309943
96mitochondrial respiratory chain complex assembly (GO:0033108)2.72731101
97cellular component biogenesis (GO:0044085)2.72557729
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.70748101
99NADH dehydrogenase complex assembly (GO:0010257)2.70748101
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70748101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48008029
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74242286
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.51293567
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.99906216
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.81280130
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.70585456
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52048939
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20976122
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.86427939
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80164269
11YY1_21170310_ChIP-Seq_MESCs_Mouse2.59347982
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55983478
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.55592803
14VDR_23849224_ChIP-Seq_CD4+_Human2.54986053
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52712561
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47470934
17VDR_22108803_ChIP-Seq_LS180_Human2.41962849
18ZNF274_21170338_ChIP-Seq_K562_Hela2.34335593
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27253285
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16085506
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.14940732
22FOXP3_21729870_ChIP-Seq_TREG_Human2.13363386
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11953512
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02016417
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01869939
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01543388
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.01314369
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.97659110
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92748193
30ELK1_19687146_ChIP-ChIP_HELA_Human1.91499982
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91472354
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67761810
33DCP1A_22483619_ChIP-Seq_HELA_Human1.63413130
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63326259
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60241091
36IRF1_19129219_ChIP-ChIP_H3396_Human1.59757466
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55899303
38GABP_19822575_ChIP-Seq_HepG2_Human1.52635462
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.49333055
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47426078
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41853357
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41485867
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40966612
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38673216
45AR_21572438_ChIP-Seq_LNCaP_Human1.35446532
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34833495
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33463076
48EWS_26573619_Chip-Seq_HEK293_Human1.30039219
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28699830
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28206827
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27622983
52TTF2_22483619_ChIP-Seq_HELA_Human1.26878365
53XRN2_22483619_ChIP-Seq_HELA_Human1.24808692
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20742141
55MYC_18940864_ChIP-ChIP_HL60_Human1.18727319
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.18010915
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15969587
58AR_20517297_ChIP-Seq_VCAP_Human1.11879160
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11127298
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.09925137
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.09629970
62IGF1R_20145208_ChIP-Seq_DFB_Human1.07755913
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04974513
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02038618
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00684806
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00491488
67NANOG_20526341_ChIP-Seq_ESCs_Human0.99428256
68NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99351140
69ER_23166858_ChIP-Seq_MCF-7_Human0.97969436
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96675168
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95016952
72SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94338986
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93199480
74BCL6_27268052_Chip-Seq_Bcells_Human0.92426099
75NCOR_22424771_ChIP-Seq_293T_Human0.92317935
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90326079
77ESR1_21235772_ChIP-Seq_MCF-7_Human0.90269528
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89545625
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89051011
80FOXA1_25329375_ChIP-Seq_VCAP_Human0.87826012
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87826012
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85680870
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85303851
84STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84822693
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84624256
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.83870242
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83551868
88ERG_20517297_ChIP-Seq_VCAP_Human0.82997068
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81448315
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81430147
91HTT_18923047_ChIP-ChIP_STHdh_Human0.80874422
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80437853
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80380421
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79857799
95TAF2_19829295_ChIP-Seq_ESCs_Human0.79367822
96E2F1_20622854_ChIP-Seq_HELA_Human0.79043171
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.78423666
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78276985
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78218785
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.77573772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure4.64186661
2MP0008058_abnormal_DNA_repair3.85361128
3MP0008872_abnormal_physiological_respon3.40547081
4MP0002163_abnormal_gland_morphology3.32493270
5MP0006036_abnormal_mitochondrial_physio2.49214564
6MP0004742_abnormal_vestibular_system2.46304283
7MP0004957_abnormal_blastocyst_morpholog2.44777383
8MP0003718_maternal_effect2.43786348
9MP0006035_abnormal_mitochondrial_morpho2.36360870
10MP0005671_abnormal_response_to2.21881248
11MP0005379_endocrine/exocrine_gland_phen2.15776546
12MP0002736_abnormal_nociception_after2.11884046
13MP0005083_abnormal_biliary_tract2.09690354
14MP0005645_abnormal_hypothalamus_physiol1.99562230
15MP0006054_spinal_hemorrhage1.95796702
16MP0003866_abnormal_defecation1.94591330
17MP0001529_abnormal_vocalization1.93842737
18MP0008875_abnormal_xenobiotic_pharmacok1.90466569
19MP0001346_abnormal_lacrimal_gland1.88190169
20MP0001485_abnormal_pinna_reflex1.86149248
21MP0002102_abnormal_ear_morphology1.84455793
22MP0004885_abnormal_endolymph1.80264904
23MP0003806_abnormal_nucleotide_metabolis1.79965500
24MP0002160_abnormal_reproductive_system1.76989731
25MP0003011_delayed_dark_adaptation1.75119711
26MP0003186_abnormal_redox_activity1.73820101
27MP0003252_abnormal_bile_duct1.70229163
28MP0005084_abnormal_gallbladder_morpholo1.61740019
29MP0001968_abnormal_touch/_nociception1.61504766
30MP0003878_abnormal_ear_physiology1.57833118
31MP0005377_hearing/vestibular/ear_phenot1.57833118
32MP0010368_abnormal_lymphatic_system1.56247739
33MP0009333_abnormal_splenocyte_physiolog1.53182479
34MP0009697_abnormal_copulation1.51488290
35MP0005167_abnormal_blood-brain_barrier1.45874102
36MP0006292_abnormal_olfactory_placode1.44779007
37MP0006276_abnormal_autonomic_nervous1.43505594
38MP0001905_abnormal_dopamine_level1.43049306
39MP0009785_altered_susceptibility_to1.38748833
40MP0005085_abnormal_gallbladder_physiolo1.36745941
41MP0002234_abnormal_pharynx_morphology1.36581585
42MP0002166_altered_tumor_susceptibility1.29838404
43MP0003786_premature_aging1.28466604
44MP0010094_abnormal_chromosome_stability1.25131189
45MP0003567_abnormal_fetal_cardiomyocyte1.25061131
46MP0010386_abnormal_urinary_bladder1.24759451
47MP0005365_abnormal_bile_salt1.21914248
48MP0002928_abnormal_bile_duct1.21475295
49MP0003137_abnormal_impulse_conducting1.19849310
50MP0008932_abnormal_embryonic_tissue1.18072569
51MP0006072_abnormal_retinal_apoptosis1.17869022
52MP0005623_abnormal_meninges_morphology1.15199199
53MP0005636_abnormal_mineral_homeostasis1.14398888
54MP0004142_abnormal_muscle_tone1.14242077
55MP0005389_reproductive_system_phenotype1.13370977
56MP0001919_abnormal_reproductive_system1.12294193
57MP0002006_tumorigenesis1.11005547
58MP0008789_abnormal_olfactory_epithelium1.10094511
59MP0001853_heart_inflammation1.08622944
60MP0001800_abnormal_humoral_immune1.08400294
61MP0001440_abnormal_grooming_behavior1.05520606
62MP0002396_abnormal_hematopoietic_system1.05473436
63MP0005253_abnormal_eye_physiology1.01606708
64MP0002138_abnormal_hepatobiliary_system0.99747623
65MP0001986_abnormal_taste_sensitivity0.99390349
66MP0003787_abnormal_imprinting0.99193396
67MP0002876_abnormal_thyroid_physiology0.96384030
68MP0001873_stomach_inflammation0.91782574
69MP0008995_early_reproductive_senescence0.91076813
70MP0009745_abnormal_behavioral_response0.89461084
71MP0005551_abnormal_eye_electrophysiolog0.85231530
72MP0005670_abnormal_white_adipose0.82875071
73MP0009046_muscle_twitch0.82051869
74MP0001663_abnormal_digestive_system0.81779557
75MP0000490_abnormal_crypts_of0.81754103
76MP0005410_abnormal_fertilization0.81622361
77MP0003693_abnormal_embryo_hatching0.80080106
78MP0001835_abnormal_antigen_presentation0.79069782
79MP0001984_abnormal_olfaction0.77595927
80MP0003077_abnormal_cell_cycle0.74612221
81MP0001881_abnormal_mammary_gland0.74348453
82MP0005360_urolithiasis0.72434134
83MP0003880_abnormal_central_pattern0.72170427
84MP0003111_abnormal_nucleus_morphology0.72149051
85MP0008961_abnormal_basal_metabolism0.70802780
86MP0004782_abnormal_surfactant_physiolog0.70562066
87MP0002210_abnormal_sex_determination0.69469797
88MP0000358_abnormal_cell_content/0.69390377
89MP0002019_abnormal_tumor_incidence0.68706956
90MP0009764_decreased_sensitivity_to0.67174505
91MP0001764_abnormal_homeostasis0.66900382
92MP0002272_abnormal_nervous_system0.66335932
93MP0001845_abnormal_inflammatory_respons0.66306592
94MP0005386_behavior/neurological_phenoty0.66071622
95MP0004924_abnormal_behavior0.66071622
96MP0004215_abnormal_myocardial_fiber0.65501226
97MP0001544_abnormal_cardiovascular_syste0.65091088
98MP0005385_cardiovascular_system_phenoty0.65091088
99MP0002693_abnormal_pancreas_physiology0.65040258
100MP0001929_abnormal_gametogenesis0.64585669

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)6.57380774
2Stomach cancer (HP:0012126)6.38654481
3Autoimmune thrombocytopenia (HP:0001973)5.52000878
4Abnormality of B cell number (HP:0010975)5.26604341
5Autoimmune hemolytic anemia (HP:0001890)5.02413505
6Colon cancer (HP:0003003)4.92635201
7Congenital stationary night blindness (HP:0007642)4.36179351
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.19325183
9Acute necrotizing encephalopathy (HP:0006965)3.86676656
10Abnormality of the renal cortex (HP:0011035)3.86645946
11Renal cortical cysts (HP:0000803)3.68604717
12Eosinophilia (HP:0001880)3.66843814
13Acute encephalopathy (HP:0006846)3.53810704
14Pancytopenia (HP:0001876)3.50175114
15IgG deficiency (HP:0004315)3.29856458
16Abnormal mitochondria in muscle tissue (HP:0008316)3.29678731
173-Methylglutaconic aciduria (HP:0003535)3.25766847
18Mitochondrial inheritance (HP:0001427)3.23556158
19Progressive macrocephaly (HP:0004481)3.18612404
20Hyperglycinemia (HP:0002154)3.09616105
21Increased CSF lactate (HP:0002490)3.06320002
22Testicular atrophy (HP:0000029)2.88753454
23Optic disc pallor (HP:0000543)2.86815856
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.84915945
25Granulocytopenia (HP:0001913)2.75094342
26Hepatic necrosis (HP:0002605)2.70978558
27Hepatocellular necrosis (HP:0001404)2.67850336
28Abnormality of T cell number (HP:0011839)2.66208184
29Oral leukoplakia (HP:0002745)2.64786595
30Abnormality of eosinophils (HP:0001879)2.63571775
31Methylmalonic aciduria (HP:0012120)2.58460051
32Cellular immunodeficiency (HP:0005374)2.53232510
33Abnormality of the renal medulla (HP:0100957)2.50589723
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43148063
35Abnormality of serum amino acid levels (HP:0003112)2.41681097
36Respiratory failure (HP:0002878)2.39069016
37Methylmalonic acidemia (HP:0002912)2.38663964
38Hyperglycinuria (HP:0003108)2.37431814
39Abnormality of T cell physiology (HP:0011840)2.36023849
40Impaired proprioception (HP:0010831)2.35905652
41Pancreatic cysts (HP:0001737)2.34797357
42Elevated erythrocyte sedimentation rate (HP:0003565)2.30534308
43Hypergammaglobulinemia (HP:0010702)2.29368552
44Reticulocytopenia (HP:0001896)2.28338812
45Cerebral edema (HP:0002181)2.27800748
46Lactic acidosis (HP:0003128)2.25276116
47Metabolic alkalosis (HP:0200114)2.24382832
48Tinnitus (HP:0000360)2.24303507
49Constricted visual fields (HP:0001133)2.22730146
50Leukodystrophy (HP:0002415)2.20816560
51Abnormal biliary tract physiology (HP:0012439)2.19685969
52Bile duct proliferation (HP:0001408)2.19685969
53Hypoplasia of the pons (HP:0012110)2.17154855
54Hypoproteinemia (HP:0003075)2.16581993
55Abnormality of the ileum (HP:0001549)2.16318869
56Abnormality of serine family amino acid metabolism (HP:0010894)2.13349219
57Abnormality of glycine metabolism (HP:0010895)2.13349219
58Meckel diverticulum (HP:0002245)2.07772687
59Pigmentary retinal degeneration (HP:0001146)2.05916034
60Increased serum lactate (HP:0002151)2.05423753
61Erythroderma (HP:0001019)2.01847476
62Pancreatic fibrosis (HP:0100732)2.00734198
63Abnormality of the preputium (HP:0100587)2.00267355
64Aplastic anemia (HP:0001915)1.99874869
65Tubulointerstitial fibrosis (HP:0005576)1.97968433
66Hypochromic anemia (HP:0001931)1.97911254
67Volvulus (HP:0002580)1.97071077
68Hypoplastic pelvis (HP:0008839)1.97069259
69Hypokalemic alkalosis (HP:0001949)1.96780872
70Abnormality of the pons (HP:0007361)1.95141139
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91721753
72Macrocytic anemia (HP:0001972)1.91637409
73Spontaneous abortion (HP:0005268)1.89669749
74Cleft eyelid (HP:0000625)1.89025739
75Alkalosis (HP:0001948)1.88876454
76Nephronophthisis (HP:0000090)1.88246724
77Congenital, generalized hypertrichosis (HP:0004540)1.86330186
78Acute hepatic failure (HP:0006554)1.81987498
79Abnormality of T cells (HP:0002843)1.80047415
80Thrombocytosis (HP:0001894)1.79467530
81Attenuation of retinal blood vessels (HP:0007843)1.78305146
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78188536
83Abnormality of alanine metabolism (HP:0010916)1.78188536
84Hyperalaninemia (HP:0003348)1.78188536
85IgM deficiency (HP:0002850)1.77718811
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.77000390
87Carpal bone hypoplasia (HP:0001498)1.74203570
88Menstrual irregularities (HP:0000858)1.73211674
89Dry hair (HP:0011359)1.72695568
90Lethargy (HP:0001254)1.71839127
91Optic nerve coloboma (HP:0000588)1.68113541
92Parakeratosis (HP:0001036)1.65709132
93Rough bone trabeculation (HP:0100670)1.65102513
94Reduced subcutaneous adipose tissue (HP:0003758)1.64283883
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62350697
96Dicarboxylic aciduria (HP:0003215)1.62350697
97Pendular nystagmus (HP:0012043)1.61829003
98Megaloblastic anemia (HP:0001889)1.60961068
99Type II lissencephaly (HP:0007260)1.58855713
100Clubbing of toes (HP:0100760)1.58306467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.69230929
2PINK14.01021346
3PASK2.97994310
4VRK22.96321483
5TLK12.88322336
6BUB12.75238241
7MST42.66291730
8WNK32.51457098
9TSSK62.45192136
10GRK12.38657799
11TXK2.38260516
12KDR2.37456293
13ZAK2.29646381
14SIK22.14534624
15VRK11.98315135
16SRPK11.81911240
17FRK1.75084185
18MAP3K131.74778721
19BMPR1B1.73831639
20NME11.67895929
21EIF2AK11.67070075
22CAMKK21.56501784
23WNK41.46517739
24CAMKK11.37301326
25NUAK11.31036515
26NEK11.28887829
27ADRBK21.17817730
28DYRK21.17217603
29NME21.13305923
30CSNK1G31.09521482
31CSNK1A1L1.09298617
32BCKDK1.02630446
33WEE11.00671730
34BCR0.96581488
35PLK20.95519955
36TEC0.95240133
37TAOK10.89700786
38TAF10.85913435
39TAOK20.83397974
40PLK30.82877744
41IRAK40.82606391
42CSNK1G20.82442460
43ERBB30.82098889
44NEK20.78519935
45PLK40.78321948
46CSNK1G10.77949248
47AKT30.77921915
48TESK20.75853239
49JAK30.75325473
50CASK0.75006639
51RPS6KA50.73780320
52TRIM280.73654638
53PRKD30.70897108
54TGFBR10.65373914
55NEK60.65328430
56KIT0.63713802
57PHKG10.63345022
58PHKG20.63345022
59LIMK10.62297206
60ABL20.62216615
61TYK20.61110247
62INSRR0.60825571
63PDK20.60485057
64MAPKAPK30.59866401
65EIF2AK30.56577685
66MAP4K20.53775322
67STK390.52859446
68MAP3K120.51596837
69AURKB0.48464144
70IGF1R0.48453649
71STK40.48213591
72IKBKE0.47595052
73CDK80.46866879
74DAPK10.45902046
75LMTK20.44349997
76CSNK2A10.44063690
77PLK10.42994626
78CDC70.41761931
79DAPK20.41489588
80MAP3K140.40937701
81TAOK30.39175030
82GRK50.38818720
83EIF2AK20.34250401
84PIK3CA0.34111639
85PNCK0.33953038
86ITK0.33791038
87AURKA0.33220067
88CSNK2A20.32473971
89PIM20.32328652
90MAPK130.31454186
91CHEK20.31282924
92PRKCD0.30336490
93CDK90.30315447
94CDK180.30029461
95MAP3K110.29829888
96AKT20.28740584
97PRKCQ0.27697713
98DAPK30.27647397
99ATR0.27430634
100TESK10.27040620

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.18282530
2Oxidative phosphorylation_Homo sapiens_hsa001903.32421644
3DNA replication_Homo sapiens_hsa030303.04567888
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.01943287
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90167873
6Parkinsons disease_Homo sapiens_hsa050122.70906859
7RNA polymerase_Homo sapiens_hsa030202.63970799
8Base excision repair_Homo sapiens_hsa034102.52926657
9Ribosome_Homo sapiens_hsa030102.45152574
10Mismatch repair_Homo sapiens_hsa034302.20669101
11Propanoate metabolism_Homo sapiens_hsa006402.05266108
12Fanconi anemia pathway_Homo sapiens_hsa034602.04240923
13Homologous recombination_Homo sapiens_hsa034402.03031369
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96312233
15Huntingtons disease_Homo sapiens_hsa050161.95122405
16Pyruvate metabolism_Homo sapiens_hsa006201.89317844
17Alzheimers disease_Homo sapiens_hsa050101.79099910
18Nucleotide excision repair_Homo sapiens_hsa034201.78138876
19Pyrimidine metabolism_Homo sapiens_hsa002401.72901736
20Spliceosome_Homo sapiens_hsa030401.72113263
21One carbon pool by folate_Homo sapiens_hsa006701.69433390
22RNA degradation_Homo sapiens_hsa030181.66897208
23Protein export_Homo sapiens_hsa030601.66679958
24Primary immunodeficiency_Homo sapiens_hsa053401.50767272
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46271066
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44068255
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42525643
28Steroid biosynthesis_Homo sapiens_hsa001001.38295126
29Glutathione metabolism_Homo sapiens_hsa004801.36844708
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35773469
31Systemic lupus erythematosus_Homo sapiens_hsa053221.30792406
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30644100
33Caffeine metabolism_Homo sapiens_hsa002321.27350525
34Nitrogen metabolism_Homo sapiens_hsa009101.25698768
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.21601354
36Cardiac muscle contraction_Homo sapiens_hsa042601.19278211
37Folate biosynthesis_Homo sapiens_hsa007901.18921056
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18457466
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.16272358
40Basal transcription factors_Homo sapiens_hsa030221.14382735
41Tryptophan metabolism_Homo sapiens_hsa003801.11976018
42Fat digestion and absorption_Homo sapiens_hsa049751.11695660
43Non-homologous end-joining_Homo sapiens_hsa034501.11460463
44RNA transport_Homo sapiens_hsa030131.11313822
45Fatty acid elongation_Homo sapiens_hsa000621.07264807
46Linoleic acid metabolism_Homo sapiens_hsa005911.01149933
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00586242
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95905366
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92767166
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90861100
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90390689
52Chemical carcinogenesis_Homo sapiens_hsa052040.86158736
53Autoimmune thyroid disease_Homo sapiens_hsa053200.84916362
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84654359
55Alcoholism_Homo sapiens_hsa050340.83832672
56Purine metabolism_Homo sapiens_hsa002300.83648380
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83377087
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81173961
59Allograft rejection_Homo sapiens_hsa053300.80238630
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78919757
61Retinol metabolism_Homo sapiens_hsa008300.72289604
62Graft-versus-host disease_Homo sapiens_hsa053320.68617644
63Antigen processing and presentation_Homo sapiens_hsa046120.66824926
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.64604233
65Metabolic pathways_Homo sapiens_hsa011000.62915532
66Hematopoietic cell lineage_Homo sapiens_hsa046400.61320473
67Arachidonic acid metabolism_Homo sapiens_hsa005900.60585901
68Carbon metabolism_Homo sapiens_hsa012000.59931966
69Type I diabetes mellitus_Homo sapiens_hsa049400.59712878
70Fatty acid degradation_Homo sapiens_hsa000710.57477100
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56827256
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56302084
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55811910
74Peroxisome_Homo sapiens_hsa041460.55711674
75p53 signaling pathway_Homo sapiens_hsa041150.55506987
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55344232
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55293213
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53046477
79Arginine and proline metabolism_Homo sapiens_hsa003300.51924074
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.51344856
81Cell cycle_Homo sapiens_hsa041100.51110955
82Phototransduction_Homo sapiens_hsa047440.50895204
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.47606539
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46893102
85beta-Alanine metabolism_Homo sapiens_hsa004100.45803152
86Fatty acid metabolism_Homo sapiens_hsa012120.45275036
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42137431
88Biosynthesis of amino acids_Homo sapiens_hsa012300.41991031
89Measles_Homo sapiens_hsa051620.38351286
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37068710
91Rheumatoid arthritis_Homo sapiens_hsa053230.33973048
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33703800
93Tyrosine metabolism_Homo sapiens_hsa003500.31896546
94Butanoate metabolism_Homo sapiens_hsa006500.31281082
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30238820
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28830319
97Glycerolipid metabolism_Homo sapiens_hsa005610.26139710
98Pancreatic secretion_Homo sapiens_hsa049720.24299005
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24098770
100Epstein-Barr virus infection_Homo sapiens_hsa051690.20815498

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