PPIAP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.83213566
2establishment of protein localization to mitochondrial membrane (GO:0090151)5.09627531
3GTP biosynthetic process (GO:0006183)5.07199847
4regulation of chronic inflammatory response (GO:0002676)4.79368938
5DNA deamination (GO:0045006)4.56985577
6cullin deneddylation (GO:0010388)4.38637630
7respiratory chain complex IV assembly (GO:0008535)4.37889745
8UTP biosynthetic process (GO:0006228)4.33342356
9protein deneddylation (GO:0000338)4.02197714
10pseudouridine synthesis (GO:0001522)4.00934886
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93616318
12UTP metabolic process (GO:0046051)3.92530129
13protein neddylation (GO:0045116)3.92367847
14ubiquinone biosynthetic process (GO:0006744)3.85856800
15detection of light stimulus involved in sensory perception (GO:0050962)3.85249985
16detection of light stimulus involved in visual perception (GO:0050908)3.85249985
17chaperone-mediated protein transport (GO:0072321)3.84539305
18energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79392060
19ATP synthesis coupled proton transport (GO:0015986)3.79392060
20water-soluble vitamin biosynthetic process (GO:0042364)3.76902188
217-methylguanosine mRNA capping (GO:0006370)3.75132642
22cytochrome complex assembly (GO:0017004)3.72830057
23protein complex biogenesis (GO:0070271)3.71249586
24regulation of cellular amino acid metabolic process (GO:0006521)3.65342010
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64916311
267-methylguanosine RNA capping (GO:0009452)3.64804440
27RNA capping (GO:0036260)3.64804440
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63916904
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63916904
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63066206
31preassembly of GPI anchor in ER membrane (GO:0016254)3.58120349
32CTP metabolic process (GO:0046036)3.55303403
33CTP biosynthetic process (GO:0006241)3.55303403
34maturation of 5.8S rRNA (GO:0000460)3.54955438
35mitochondrial respiratory chain complex assembly (GO:0033108)3.54730395
36ubiquinone metabolic process (GO:0006743)3.51740029
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.51396910
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.51396910
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51338728
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51338728
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51338728
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50226819
43fucose catabolic process (GO:0019317)3.46575248
44L-fucose metabolic process (GO:0042354)3.46575248
45L-fucose catabolic process (GO:0042355)3.46575248
46negative regulation of neurological system process (GO:0031645)3.43744525
47transcription elongation from RNA polymerase I promoter (GO:0006362)3.42917702
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35714416
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.35714416
50NADH dehydrogenase complex assembly (GO:0010257)3.35714416
51positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.34984544
52respiratory electron transport chain (GO:0022904)3.33627372
53rRNA modification (GO:0000154)3.31508790
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31407487
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.31407487
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31102742
57electron transport chain (GO:0022900)3.29499263
58nucleoside diphosphate phosphorylation (GO:0006165)3.28038376
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.25118867
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19402812
61cyclic nucleotide catabolic process (GO:0009214)3.17793857
62negative regulation of ligase activity (GO:0051352)3.16227458
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16227458
64rRNA methylation (GO:0031167)3.15280450
65branched-chain amino acid catabolic process (GO:0009083)3.15031577
66regulation of protein kinase A signaling (GO:0010738)3.14569446
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14271262
68behavioral response to nicotine (GO:0035095)3.13894872
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.11444897
70termination of RNA polymerase III transcription (GO:0006386)3.11444897
71pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.10400573
72quinone biosynthetic process (GO:1901663)3.09784610
73cAMP catabolic process (GO:0006198)3.04052068
74purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01797526
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01648482
76tRNA processing (GO:0008033)3.00022949
77protein peptidyl-prolyl isomerization (GO:0000413)2.98888464
78regulation of glucokinase activity (GO:0033131)2.98436851
79regulation of hexokinase activity (GO:1903299)2.98436851
80protein targeting to mitochondrion (GO:0006626)2.97930144
81L-methionine salvage (GO:0071267)2.97315814
82L-methionine biosynthetic process (GO:0071265)2.97315814
83amino acid salvage (GO:0043102)2.97315814
84meiotic chromosome segregation (GO:0045132)2.96322028
85intracellular protein transmembrane import (GO:0044743)2.95373865
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.95131104
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94700923
88mitochondrial RNA metabolic process (GO:0000959)2.92681727
89anterograde synaptic vesicle transport (GO:0048490)2.91049607
90signal peptide processing (GO:0006465)2.89434564
91protein localization to mitochondrion (GO:0070585)2.89364444
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88690309
93isotype switching (GO:0045190)2.88690309
94somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88690309
95termination of RNA polymerase I transcription (GO:0006363)2.88135058
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87446890
97DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87208556
98pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.86799026
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85216504
100establishment of protein localization to mitochondrion (GO:0072655)2.84135160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.74570525
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.52821591
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27442809
4VDR_22108803_ChIP-Seq_LS180_Human3.52752931
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52249279
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17562489
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.13711550
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99406737
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99404511
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.83484527
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.70809703
12VDR_23849224_ChIP-Seq_CD4+_Human2.41539097
13FOXP3_21729870_ChIP-Seq_TREG_Human2.32665941
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25162475
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21169501
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.20781553
17ZNF274_21170338_ChIP-Seq_K562_Hela2.10534936
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07974682
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00862130
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.99142102
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92424235
22ELK1_19687146_ChIP-ChIP_HELA_Human1.80598010
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.72070697
24FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69347926
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65845105
26FUS_26573619_Chip-Seq_HEK293_Human1.61407590
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59856818
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59482492
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53143413
30MYC_18940864_ChIP-ChIP_HL60_Human1.46473749
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.43146696
32GABP_19822575_ChIP-Seq_HepG2_Human1.43127182
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.39564932
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38949217
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.37611088
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36272099
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35636371
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33679482
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33077763
40IRF1_19129219_ChIP-ChIP_H3396_Human1.33000419
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32718634
42TP53_22573176_ChIP-Seq_HFKS_Human1.32696882
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29185081
44EWS_26573619_Chip-Seq_HEK293_Human1.29125991
45P300_19829295_ChIP-Seq_ESCs_Human1.28215326
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27679144
47ER_23166858_ChIP-Seq_MCF-7_Human1.24655760
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.21837247
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19913368
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18689816
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.17634219
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17246399
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15073203
54HOXB7_26014856_ChIP-Seq_BT474_Human1.15034804
55NANOG_19829295_ChIP-Seq_ESCs_Human1.14931944
56SOX2_19829295_ChIP-Seq_ESCs_Human1.14931944
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14856158
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14798470
59NCOR_22424771_ChIP-Seq_293T_Human1.12765782
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.12751450
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12751450
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11662260
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11505862
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.08277231
65TTF2_22483619_ChIP-Seq_HELA_Human1.08229473
66AR_20517297_ChIP-Seq_VCAP_Human1.06969932
67DCP1A_22483619_ChIP-Seq_HELA_Human1.05027128
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04260830
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04256843
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04229541
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04228253
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03403590
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02669914
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02406238
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.00838845
76POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99996244
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.99454527
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97436677
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96551699
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94862057
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92132329
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.92036076
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91748245
84PHF8_20622853_ChIP-Seq_HELA_Human0.89813647
85GATA3_26560356_Chip-Seq_TH2_Human0.89505797
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89232992
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88429267
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.87064869
89STAT3_18555785_Chip-Seq_ESCs_Mouse0.86682085
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86299527
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.84576618
92NFYB_21822215_ChIP-Seq_K562_Human0.84567063
93GBX2_23144817_ChIP-Seq_PC3_Human0.84204284
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83804337
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82601143
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.82304627
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81943792
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81427227
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80398400
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80166758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.32926088
2MP0003950_abnormal_plasma_membrane3.87886702
3MP0000685_abnormal_immune_system2.72749404
4MP0003786_premature_aging2.71572308
5MP0001501_abnormal_sleep_pattern2.59523243
6MP0002102_abnormal_ear_morphology2.53845450
7MP0005645_abnormal_hypothalamus_physiol2.50192637
8MP0008877_abnormal_DNA_methylation2.44084529
9MP0006036_abnormal_mitochondrial_physio2.36021777
10MP0001873_stomach_inflammation2.27821575
11MP0006035_abnormal_mitochondrial_morpho2.21751988
12MP0009785_altered_susceptibility_to2.13289930
13MP0003806_abnormal_nucleotide_metabolis2.11647252
14MP0005671_abnormal_response_to2.08426368
15MP0003195_calcinosis2.03021005
16MP0004145_abnormal_muscle_electrophysio1.98869523
17MP0005551_abnormal_eye_electrophysiolog1.91399342
18MP0001835_abnormal_antigen_presentation1.87589983
19MP0003186_abnormal_redox_activity1.83626886
20MP0004142_abnormal_muscle_tone1.80803252
21MP0002396_abnormal_hematopoietic_system1.74968891
22MP0009333_abnormal_splenocyte_physiolog1.70514354
23MP0005360_urolithiasis1.69677456
24MP0010094_abnormal_chromosome_stability1.66026092
25MP0003718_maternal_effect1.62864957
26MP0000427_abnormal_hair_cycle1.61529141
27MP0002876_abnormal_thyroid_physiology1.61134937
28MP0002837_dystrophic_cardiac_calcinosis1.60526032
29MP0002138_abnormal_hepatobiliary_system1.60202681
30MP0001968_abnormal_touch/_nociception1.59707872
31MP0002693_abnormal_pancreas_physiology1.55834817
32MP0006082_CNS_inflammation1.54625668
33MP0010386_abnormal_urinary_bladder1.52512171
34MP0003011_delayed_dark_adaptation1.45259883
35MP0009046_muscle_twitch1.43736528
36MP0002148_abnormal_hypersensitivity_rea1.41107290
37MP0003646_muscle_fatigue1.36467243
38MP0006072_abnormal_retinal_apoptosis1.33865606
39MP0009745_abnormal_behavioral_response1.32980156
40MP0001800_abnormal_humoral_immune1.32297469
41MP0004885_abnormal_endolymph1.31794040
42MP0002272_abnormal_nervous_system1.30319956
43MP0005253_abnormal_eye_physiology1.29811336
44MP0008875_abnormal_xenobiotic_pharmacok1.29591140
45MP0005084_abnormal_gallbladder_morpholo1.28210514
46MP0008872_abnormal_physiological_respon1.24043350
47MP0005410_abnormal_fertilization1.23724125
48MP0006276_abnormal_autonomic_nervous1.22291744
49MP0001440_abnormal_grooming_behavior1.21583282
50MP0001661_extended_life_span1.20533917
51MP0004742_abnormal_vestibular_system1.19448815
52MP0002909_abnormal_adrenal_gland1.18485031
53MP0005670_abnormal_white_adipose1.18132647
54MP0004381_abnormal_hair_follicle1.14740267
55MP0004147_increased_porphyrin_level1.14731438
56MP0005387_immune_system_phenotype1.09855312
57MP0001790_abnormal_immune_system1.09855312
58MP0001348_abnormal_lacrimal_gland1.09587856
59MP0009764_decreased_sensitivity_to1.08555056
60MP0004043_abnormal_pH_regulation1.06926796
61MP0002254_reproductive_system_inflammat1.06577140
62MP0001905_abnormal_dopamine_level1.06565767
63MP0002736_abnormal_nociception_after1.05537189
64MP0009840_abnormal_foam_cell1.03247464
65MP0001944_abnormal_pancreas_morphology0.98958032
66MP0002723_abnormal_immune_serum0.97869878
67MP0005000_abnormal_immune_tolerance0.94144404
68MP0005310_abnormal_salivary_gland0.93587971
69MP0002210_abnormal_sex_determination0.93358475
70MP0006292_abnormal_olfactory_placode0.91357263
71MP0005408_hypopigmentation0.90787165
72MP0000358_abnormal_cell_content/0.89989996
73MP0005025_abnormal_response_to0.89746217
74MP0002234_abnormal_pharynx_morphology0.89640605
75MP0008469_abnormal_protein_level0.86228311
76MP0003252_abnormal_bile_duct0.84912120
77MP0004957_abnormal_blastocyst_morpholog0.83771304
78MP0003436_decreased_susceptibility_to0.83619619
79MP0002064_seizures0.83549782
80MP0005448_abnormal_energy_balance0.82282892
81MP0005085_abnormal_gallbladder_physiolo0.81401444
82MP0002638_abnormal_pupillary_reflex0.80731214
83MP0001845_abnormal_inflammatory_respons0.79973122
84MP0002938_white_spotting0.79829494
85MP0005379_endocrine/exocrine_gland_phen0.79011678
86MP0001929_abnormal_gametogenesis0.78804842
87MP0005389_reproductive_system_phenotype0.78730896
88MP0002269_muscular_atrophy0.77367964
89MP0005332_abnormal_amino_acid0.76746436
90MP0001819_abnormal_immune_cell0.76503877
91MP0002452_abnormal_antigen_presenting0.76468453
92MP0002733_abnormal_thermal_nociception0.75698816
93MP0002420_abnormal_adaptive_immunity0.75570098
94MP0003866_abnormal_defecation0.74915474
95MP0004215_abnormal_myocardial_fiber0.73476328
96MP0001970_abnormal_pain_threshold0.72464042
97MP0008995_early_reproductive_senescence0.71319914
98MP0000689_abnormal_spleen_morphology0.71243191
99MP0001666_abnormal_nutrient_absorption0.70846304
100MP0005636_abnormal_mineral_homeostasis0.70550448

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.03562071
2Abnormality of macular pigmentation (HP:0008002)5.18095609
3Aplasia/Hypoplasia of the fovea (HP:0008060)4.85876892
4Hypoplasia of the fovea (HP:0007750)4.85876892
5Acute necrotizing encephalopathy (HP:0006965)4.77928776
6Central scotoma (HP:0000603)4.59884908
7Abnormal rod and cone electroretinograms (HP:0008323)4.31562707
8Acute encephalopathy (HP:0006846)4.15782706
9Progressive macrocephaly (HP:0004481)4.05824477
10Abnormal mitochondria in muscle tissue (HP:0008316)4.05329223
113-Methylglutaconic aciduria (HP:0003535)3.81632490
12Increased CSF lactate (HP:0002490)3.78166038
13Mitochondrial inheritance (HP:0001427)3.77181556
14Abnormality of the fovea (HP:0000493)3.74863113
15Hepatic necrosis (HP:0002605)3.63428371
16Hepatocellular necrosis (HP:0001404)3.59889879
17Severe visual impairment (HP:0001141)3.59792847
18Albinism (HP:0001022)3.50516496
19Optic neuritis (HP:0100653)3.49305049
20Retrobulbar optic neuritis (HP:0100654)3.49305049
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.36063141
22Large for gestational age (HP:0001520)3.28916495
23Abnormality of the anterior horn cell (HP:0006802)3.28531087
24Degeneration of anterior horn cells (HP:0002398)3.28531087
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.19255833
26Aplasia/Hypoplasia of the macula (HP:0008059)3.06223857
27Increased serum lactate (HP:0002151)3.03526270
28Cerebral edema (HP:0002181)2.99920262
29Aplasia/Hypoplasia affecting the retina (HP:0008061)2.88365182
30Abnormality of the pons (HP:0007361)2.79174486
31Limb dystonia (HP:0002451)2.77656527
32Optic disc pallor (HP:0000543)2.75748186
33Lipid accumulation in hepatocytes (HP:0006561)2.74905672
34Chronic hepatic failure (HP:0100626)2.73725847
35Hypothermia (HP:0002045)2.71011155
36Scotoma (HP:0000575)2.70919245
37Orchitis (HP:0100796)2.69459728
38Increased hepatocellular lipid droplets (HP:0006565)2.68198097
39Abnormality of the pancreatic islet cells (HP:0006476)2.61965807
40Abnormality of endocrine pancreas physiology (HP:0012093)2.61965807
41Cortical visual impairment (HP:0100704)2.60833849
42Dyschromatopsia (HP:0007641)2.58225208
43Keratoconjunctivitis (HP:0001096)2.54818973
44Duplicated collecting system (HP:0000081)2.52512433
45Generalized aminoaciduria (HP:0002909)2.51768759
46Abnormality of the renal cortex (HP:0011035)2.51512691
47Hypoglycemic coma (HP:0001325)2.47229090
48Abnormality of the renal collecting system (HP:0004742)2.42694559
49Oral leukoplakia (HP:0002745)2.42090401
50Respiratory failure (HP:0002878)2.38890349
51Stomatitis (HP:0010280)2.38366627
52Keratoconjunctivitis sicca (HP:0001097)2.35152887
53Autoimmune hemolytic anemia (HP:0001890)2.33551119
54Colon cancer (HP:0003003)2.28289335
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27544338
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27544338
57Lactic acidosis (HP:0003128)2.26867275
58Exercise intolerance (HP:0003546)2.25164172
59Carpal bone hypoplasia (HP:0001498)2.14686413
60Ketoacidosis (HP:0001993)2.13155419
61Renal Fanconi syndrome (HP:0001994)2.10081905
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09498863
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08337292
64Aplastic anemia (HP:0001915)2.06175975
65Constricted visual fields (HP:0001133)2.04077282
66Anorexia (HP:0002039)2.03079299
67Gangrene (HP:0100758)2.01744487
68Lethargy (HP:0001254)2.01135338
69Tubular atrophy (HP:0000092)2.00057238
70Myositis (HP:0100614)1.98179944
71Elevated erythrocyte sedimentation rate (HP:0003565)1.97668564
72Leukodystrophy (HP:0002415)1.95325571
73Abnormality of urine glucose concentration (HP:0011016)1.93293932
74Glycosuria (HP:0003076)1.93293932
75Hemoptysis (HP:0002105)1.93089778
76Pancreatic cysts (HP:0001737)1.91770318
77Joint swelling (HP:0001386)1.91194783
78Gastrointestinal infarctions (HP:0005244)1.90481813
79Hypomagnesemia (HP:0002917)1.88989210
80Hyperinsulinemic hypoglycemia (HP:0000825)1.88433944
81Tubulointerstitial fibrosis (HP:0005576)1.88285085
82Nephronophthisis (HP:0000090)1.86994508
83Generalized hypopigmentation (HP:0007513)1.81471639
84Abnormality of midbrain morphology (HP:0002418)1.80588067
85Molar tooth sign on MRI (HP:0002419)1.80588067
86Inability to walk (HP:0002540)1.79942551
87Ketosis (HP:0001946)1.79075232
88Renal cortical cysts (HP:0000803)1.77847169
89Late onset (HP:0003584)1.76697909
90Hyperglycinuria (HP:0003108)1.75555272
91CNS demyelination (HP:0007305)1.75428469
92Prominent metopic ridge (HP:0005487)1.74824248
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73543819
94Abnormality of magnesium homeostasis (HP:0004921)1.73196981
95Polyuria (HP:0000103)1.72927339
96Pancytopenia (HP:0001876)1.71408666
97IgG deficiency (HP:0004315)1.70697793
98Muscular hypotonia of the trunk (HP:0008936)1.68385898
99Metabolic alkalosis (HP:0200114)1.68378128
100Progressive inability to walk (HP:0002505)1.67638604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.50168658
2TXK3.46509545
3FRK3.45521041
4VRK23.27636309
5MAP2K63.08576759
6EIF2AK12.86471364
7TSSK62.84904778
8MAP4K22.66668436
9MST42.56092975
10TRIM282.46404652
11MAPKAPK32.20325271
12ADRBK22.19204304
13MAP3K122.15270400
14NME12.04494269
15GRK11.95924269
16WNK41.85821671
17BUB11.82115557
18MAP3K91.80393757
19STK161.69561977
20TLK11.66946667
21STK391.58312571
22DAPK11.40029830
23SRPK11.34232608
24CSNK1G31.25409801
25NEK11.22990696
26CLK11.19837479
27CSNK1A1L1.19808865
28OXSR11.19726356
29VRK11.18536348
30CSNK1G11.13992233
31ZAK1.12759919
32NTRK31.12721161
33ITK1.10298041
34NUAK11.09788225
35CSNK1G21.08754054
36TAOK31.05730479
37EIF2AK20.95219214
38MAP4K10.95037122
39PLK30.94633275
40TAF10.86801506
41BMPR1B0.84373839
42CAMKK20.81734579
43IRAK10.81082895
44ARAF0.79652182
45PHKG20.78794541
46PHKG10.78794541
47PRKCG0.77984373
48TEC0.77849830
49TIE10.77598281
50MYLK0.76942323
51MAPKAPK50.73274059
52SIK30.72959082
53STK38L0.72195041
54PBK0.71058190
55CASK0.70317830
56WNK30.67915013
57PINK10.66738297
58INSRR0.65945768
59CCNB10.65301200
60TYK20.65183712
61PAK30.61886902
62CAMK2A0.58011113
63PASK0.57647304
64NME20.54417479
65PRKCI0.53054240
66ATR0.52639105
67PIK3CA0.49339140
68ABL20.49011567
69PRKG10.47933644
70CAMK2D0.47698832
71MAPK130.47407024
72PRKCQ0.44618022
73IRAK40.43752426
74TGFBR10.43616004
75DAPK20.42379647
76CSNK1A10.41634297
77MKNK20.40702537
78DAPK30.39004422
79GRK50.37798056
80FGFR10.37789211
81IKBKB0.36969422
82DYRK20.36810724
83CAMK40.35423150
84IGF1R0.34272771
85JAK30.32758308
86GRK70.31227141
87WEE10.31103990
88CDK80.30925392
89BCKDK0.30721218
90PRKACA0.30641545
91MARK30.28590348
92LCK0.27756975
93PLK40.27749949
94MAP3K140.27098458
95CSNK1E0.25906143
96PNCK0.25395926
97PRKCB0.25142284
98BCR0.24735071
99LYN0.24469809
100FES0.24314597

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.63777213
2Protein export_Homo sapiens_hsa030603.39698860
3Oxidative phosphorylation_Homo sapiens_hsa001903.34973112
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.04969526
5Parkinsons disease_Homo sapiens_hsa050122.44475785
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37929202
7Basal transcription factors_Homo sapiens_hsa030222.36522350
8RNA polymerase_Homo sapiens_hsa030202.19304041
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07676916
10Ribosome_Homo sapiens_hsa030102.01582855
11Alzheimers disease_Homo sapiens_hsa050101.97833365
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82446769
13Collecting duct acid secretion_Homo sapiens_hsa049661.79522551
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78270037
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78174106
16Huntingtons disease_Homo sapiens_hsa050161.77245721
17Non-homologous end-joining_Homo sapiens_hsa034501.73078129
18Vitamin B6 metabolism_Homo sapiens_hsa007501.70769937
19Propanoate metabolism_Homo sapiens_hsa006401.61736609
20Nucleotide excision repair_Homo sapiens_hsa034201.59982632
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58850543
22One carbon pool by folate_Homo sapiens_hsa006701.58359315
23RNA degradation_Homo sapiens_hsa030181.52650268
24Type I diabetes mellitus_Homo sapiens_hsa049401.47189849
25Mismatch repair_Homo sapiens_hsa034301.43722655
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43435140
27Cardiac muscle contraction_Homo sapiens_hsa042601.41450712
28Linoleic acid metabolism_Homo sapiens_hsa005911.33844144
29Butanoate metabolism_Homo sapiens_hsa006501.31806008
30Nitrogen metabolism_Homo sapiens_hsa009101.31366305
31Ether lipid metabolism_Homo sapiens_hsa005651.31052832
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29523900
33Fatty acid biosynthesis_Homo sapiens_hsa000611.26341862
34Homologous recombination_Homo sapiens_hsa034401.25491166
35Pyrimidine metabolism_Homo sapiens_hsa002401.23471506
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.23060695
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.20168985
38Asthma_Homo sapiens_hsa053101.18132969
39Folate biosynthesis_Homo sapiens_hsa007901.16428849
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16215419
41Tryptophan metabolism_Homo sapiens_hsa003801.13476515
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03146584
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00832181
44Purine metabolism_Homo sapiens_hsa002301.00005634
45Fanconi anemia pathway_Homo sapiens_hsa034600.99109634
46RNA transport_Homo sapiens_hsa030130.98778547
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96121727
48Fatty acid metabolism_Homo sapiens_hsa012120.94685732
49Phototransduction_Homo sapiens_hsa047440.94481789
50Fatty acid elongation_Homo sapiens_hsa000620.92005374
51Morphine addiction_Homo sapiens_hsa050320.90903371
52Primary immunodeficiency_Homo sapiens_hsa053400.90451525
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89469988
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.87326104
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87245510
56Spliceosome_Homo sapiens_hsa030400.86750097
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86130552
58Sulfur metabolism_Homo sapiens_hsa009200.82265780
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81608772
60Selenocompound metabolism_Homo sapiens_hsa004500.81388023
61Hematopoietic cell lineage_Homo sapiens_hsa046400.77095432
62beta-Alanine metabolism_Homo sapiens_hsa004100.76396110
63Metabolic pathways_Homo sapiens_hsa011000.74284678
64Allograft rejection_Homo sapiens_hsa053300.73842440
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69945703
66Pyruvate metabolism_Homo sapiens_hsa006200.69766272
67Autoimmune thyroid disease_Homo sapiens_hsa053200.69511116
68Fatty acid degradation_Homo sapiens_hsa000710.67749064
69Peroxisome_Homo sapiens_hsa041460.66855794
70Caffeine metabolism_Homo sapiens_hsa002320.66458240
71Measles_Homo sapiens_hsa051620.65945776
72Insulin secretion_Homo sapiens_hsa049110.62792880
73Rheumatoid arthritis_Homo sapiens_hsa053230.62646015
74Fat digestion and absorption_Homo sapiens_hsa049750.58646275
75GABAergic synapse_Homo sapiens_hsa047270.57263496
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57191609
77Serotonergic synapse_Homo sapiens_hsa047260.55308083
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53159513
79Vibrio cholerae infection_Homo sapiens_hsa051100.51688680
80Base excision repair_Homo sapiens_hsa034100.50750747
81Glutathione metabolism_Homo sapiens_hsa004800.49071377
82Regulation of autophagy_Homo sapiens_hsa041400.48936183
83Arachidonic acid metabolism_Homo sapiens_hsa005900.45035311
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44943765
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.36608466
86DNA replication_Homo sapiens_hsa030300.36453298
87Graft-versus-host disease_Homo sapiens_hsa053320.35016456
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34635914
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33244910
90Olfactory transduction_Homo sapiens_hsa047400.31636165
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30659380
92Mineral absorption_Homo sapiens_hsa049780.30416527
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.30014874
94Taste transduction_Homo sapiens_hsa047420.29466857
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27502867
96Arginine and proline metabolism_Homo sapiens_hsa003300.27467765
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26127117
98N-Glycan biosynthesis_Homo sapiens_hsa005100.25642194
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.24356156
100Epstein-Barr virus infection_Homo sapiens_hsa051690.24330497

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