PPIAP29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.31419559
2cytidine deamination (GO:0009972)6.67994584
3cytidine metabolic process (GO:0046087)6.67994584
4cytidine catabolic process (GO:0006216)6.67994584
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.80889768
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.54422019
7proteasome assembly (GO:0043248)4.55419968
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91596995
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71511939
10ATP synthesis coupled proton transport (GO:0015986)3.71511939
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.70204723
12regulation of cellular amino acid metabolic process (GO:0006521)3.69994943
13protein neddylation (GO:0045116)3.63467352
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55751490
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.54834853
16water-soluble vitamin biosynthetic process (GO:0042364)3.54170836
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50483163
18protein complex biogenesis (GO:0070271)3.48396060
19respiratory electron transport chain (GO:0022904)3.44770195
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43355464
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43355464
22cullin deneddylation (GO:0010388)3.42416884
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.42292899
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.42292899
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.42292899
26electron transport chain (GO:0022900)3.42018052
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.36725812
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36024070
29negative regulation of ligase activity (GO:0051352)3.29030174
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29030174
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.28457488
32pyrimidine nucleoside catabolic process (GO:0046135)3.28394008
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.26199414
34NADH dehydrogenase complex assembly (GO:0010257)3.26199414
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26199414
36chaperone-mediated protein transport (GO:0072321)3.25100490
37negative regulation of T cell apoptotic process (GO:0070233)3.24332040
38mitochondrial respiratory chain complex assembly (GO:0033108)3.22458320
39platelet dense granule organization (GO:0060155)3.20949060
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.20896605
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.20848837
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20848837
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20333000
44protein deneddylation (GO:0000338)3.16937557
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15665961
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14151502
47deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.13637967
48sequestering of actin monomers (GO:0042989)3.07262688
49ubiquinone biosynthetic process (GO:0006744)3.03366864
50purine deoxyribonucleotide catabolic process (GO:0009155)3.01870218
51positive regulation of interleukin-8 secretion (GO:2000484)3.01710302
52positive regulation of B cell differentiation (GO:0045579)3.00358553
53respiratory chain complex IV assembly (GO:0008535)2.98235191
54Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93862668
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90686073
56iron-sulfur cluster assembly (GO:0016226)2.89769008
57metallo-sulfur cluster assembly (GO:0031163)2.89769008
58regulation of mitochondrial translation (GO:0070129)2.88979655
59base-excision repair, AP site formation (GO:0006285)2.88364681
60DNA demethylation (GO:0080111)2.86144135
61negative regulation of lymphocyte apoptotic process (GO:0070229)2.85031829
62regulation of regulatory T cell differentiation (GO:0045589)2.83224247
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82271671
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82271671
65negative T cell selection (GO:0043383)2.81029182
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77583330
67positive regulation of cell cycle arrest (GO:0071158)2.76805659
68positive regulation of ligase activity (GO:0051351)2.76383816
69ubiquinone metabolic process (GO:0006743)2.75043469
70negative regulation by host of viral transcription (GO:0043922)2.74153670
71regulation of B cell differentiation (GO:0045577)2.73890386
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73603649
73positive regulation of calcium-mediated signaling (GO:0050850)2.72958951
74cytochrome complex assembly (GO:0017004)2.71466972
75DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68293784
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66666895
77glucosamine-containing compound catabolic process (GO:1901072)2.65811124
78regulation of cellular amine metabolic process (GO:0033238)2.65584570
79T cell migration (GO:0072678)2.62618898
80quinone biosynthetic process (GO:1901663)2.60368769
81antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59661405
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.59514799
83tryptophan catabolic process (GO:0006569)2.59403736
84indole-containing compound catabolic process (GO:0042436)2.59403736
85indolalkylamine catabolic process (GO:0046218)2.59403736
86actin nucleation (GO:0045010)2.58660542
87positive regulation of defense response to virus by host (GO:0002230)2.57502092
88branched-chain amino acid catabolic process (GO:0009083)2.55746516
89cellular response to interleukin-15 (GO:0071350)2.55060827
90positive thymic T cell selection (GO:0045059)2.54411479
91rRNA modification (GO:0000154)2.53880912
92deoxyribonucleotide catabolic process (GO:0009264)2.53184315
93pseudouridine synthesis (GO:0001522)2.53033174
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.52924749
95protein targeting to mitochondrion (GO:0006626)2.52872628
96DNA catabolic process, exonucleolytic (GO:0000738)2.51853376
97DNA dealkylation (GO:0035510)2.51614612
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50963972
99positive T cell selection (GO:0043368)2.49900391
100positive regulation of prostaglandin secretion (GO:0032308)2.49704756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.86988671
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36067054
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95604065
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.89307362
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.59571139
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.51508757
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34690040
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28991355
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08854338
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68565877
11VDR_23849224_ChIP-Seq_CD4+_Human2.61982840
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43810041
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.39693709
14ZNF274_21170338_ChIP-Seq_K562_Hela2.36144898
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23178837
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21300838
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.19875991
18ELK1_19687146_ChIP-ChIP_HELA_Human2.18723272
19FOXP3_21729870_ChIP-Seq_TREG_Human2.16521581
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.10621476
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00656423
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99801034
23VDR_22108803_ChIP-Seq_LS180_Human1.99518833
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91944276
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77919267
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.77526336
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76936225
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75828994
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65777146
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65357952
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.63248451
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60145066
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.56184847
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53582869
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51319848
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.48956098
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43685249
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42233844
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40869523
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40134443
41IGF1R_20145208_ChIP-Seq_DFB_Human1.39544392
42GATA3_26560356_Chip-Seq_TH2_Human1.38228347
43MYB_26560356_Chip-Seq_TH2_Human1.37669331
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34887785
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34489861
46TP53_22573176_ChIP-Seq_HFKS_Human1.34329101
47DCP1A_22483619_ChIP-Seq_HELA_Human1.28425774
48EWS_26573619_Chip-Seq_HEK293_Human1.28177892
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.27752742
50MYC_18940864_ChIP-ChIP_HL60_Human1.27209190
51AR_20517297_ChIP-Seq_VCAP_Human1.26072505
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25748767
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.25748767
54GABP_19822575_ChIP-Seq_HepG2_Human1.25567473
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22789314
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22781790
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22475237
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20734223
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19688482
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.19346741
61CIITA_25753668_ChIP-Seq_RAJI_Human1.19109853
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17024687
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16274404
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14211842
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14073364
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13863575
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11180544
68IRF1_19129219_ChIP-ChIP_H3396_Human1.10569024
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10157299
70GATA3_27048872_Chip-Seq_THYMUS_Human1.09460538
71TAF2_19829295_ChIP-Seq_ESCs_Human1.07778174
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07631699
73TTF2_22483619_ChIP-Seq_HELA_Human1.07159126
74ERG_20517297_ChIP-Seq_VCAP_Human1.06883898
75NCOR_22424771_ChIP-Seq_293T_Human1.06196150
76ER_23166858_ChIP-Seq_MCF-7_Human1.06190301
77SPI1_23547873_ChIP-Seq_NB4_Human1.04132743
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03777014
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03727601
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03566192
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03022165
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01827584
83NANOG_20526341_ChIP-Seq_ESCs_Human0.96857503
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95900243
85SOX2_19829295_ChIP-Seq_ESCs_Human0.95868760
86NANOG_19829295_ChIP-Seq_ESCs_Human0.95868760
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95432011
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95038608
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94993573
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94884473
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93946758
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93171201
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92931505
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91507484
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90260147
96HTT_18923047_ChIP-ChIP_STHdh_Human0.90018915
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89142327
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.88702096
99MYB_26560356_Chip-Seq_TH1_Human0.88601881
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.87625718

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.30335506
2MP0002138_abnormal_hepatobiliary_system3.74359599
3MP0004147_increased_porphyrin_level3.04574801
4MP0001835_abnormal_antigen_presentation2.96612602
5MP0009785_altered_susceptibility_to2.49258653
6MP0009333_abnormal_splenocyte_physiolog2.25972008
7MP0003786_premature_aging2.18987980
8MP0002148_abnormal_hypersensitivity_rea2.17140440
9MP0002736_abnormal_nociception_after2.15246197
10MP0006036_abnormal_mitochondrial_physio2.09211055
11MP0001968_abnormal_touch/_nociception2.06841790
12MP0002102_abnormal_ear_morphology2.01166363
13MP0001800_abnormal_humoral_immune2.01113484
14MP0005646_abnormal_pituitary_gland1.99625842
15MP0005000_abnormal_immune_tolerance1.93052088
16MP0003763_abnormal_thymus_physiology1.92089537
17MP0008058_abnormal_DNA_repair1.87378939
18MP0003724_increased_susceptibility_to1.82149770
19MP0003195_calcinosis1.82049217
20MP0005360_urolithiasis1.81190144
21MP0002420_abnormal_adaptive_immunity1.75834164
22MP0008872_abnormal_physiological_respon1.73580121
23MP0005645_abnormal_hypothalamus_physiol1.71743109
24MP0001819_abnormal_immune_cell1.70437842
25MP0005084_abnormal_gallbladder_morpholo1.67886733
26MP0002723_abnormal_immune_serum1.64712440
27MP0009697_abnormal_copulation1.63352397
28MP0005025_abnormal_response_to1.61708954
29MP0006082_CNS_inflammation1.58713118
30MP0001853_heart_inflammation1.57471613
31MP0008875_abnormal_xenobiotic_pharmacok1.56247741
32MP0006035_abnormal_mitochondrial_morpho1.49672058
33MP0003252_abnormal_bile_duct1.48813759
34MP0010386_abnormal_urinary_bladder1.48032327
35MP0001790_abnormal_immune_system1.47131402
36MP0005387_immune_system_phenotype1.47131402
37MP0000685_abnormal_immune_system1.46227987
38MP0002452_abnormal_antigen_presenting1.45956515
39MP0003866_abnormal_defecation1.44081557
40MP0002876_abnormal_thyroid_physiology1.44028620
41MP0002277_abnormal_respiratory_mucosa1.43456809
42MP0003693_abnormal_embryo_hatching1.40684740
43MP0001764_abnormal_homeostasis1.39807321
44MP0003183_abnormal_peptide_metabolism1.37586850
45MP0000716_abnormal_immune_system1.36809269
46MP0002398_abnormal_bone_marrow1.35481265
47MP0003186_abnormal_redox_activity1.34461114
48MP0006276_abnormal_autonomic_nervous1.31023647
49MP0003806_abnormal_nucleotide_metabolis1.29440532
50MP0000689_abnormal_spleen_morphology1.28098230
51MP0006292_abnormal_olfactory_placode1.26702453
52MP0002132_abnormal_respiratory_system1.24362804
53MP0005085_abnormal_gallbladder_physiolo1.23517982
54MP0002722_abnormal_immune_system1.20046958
55MP0005075_abnormal_melanosome_morpholog1.19216387
56MP0002405_respiratory_system_inflammati1.18320745
57MP0002837_dystrophic_cardiac_calcinosis1.16794900
58MP0005551_abnormal_eye_electrophysiolog1.15379837
59MP0005410_abnormal_fertilization1.15051239
60MP0000372_irregular_coat_pigmentation1.14121059
61MP0006072_abnormal_retinal_apoptosis1.14017806
62MP0001845_abnormal_inflammatory_respons1.13879843
63MP0000703_abnormal_thymus_morphology1.11081960
64MP0010155_abnormal_intestine_physiology1.10974428
65MP0004145_abnormal_muscle_electrophysio1.09793397
66MP0002419_abnormal_innate_immunity1.08948208
67MP0003718_maternal_effect1.07270010
68MP0002429_abnormal_blood_cell1.05980916
69MP0001919_abnormal_reproductive_system1.05471476
70MP0003880_abnormal_central_pattern1.05467449
71MP0002166_altered_tumor_susceptibility1.05338597
72MP0005636_abnormal_mineral_homeostasis1.04956654
73MP0008469_abnormal_protein_level1.02634604
74MP0010094_abnormal_chromosome_stability1.02544914
75MP0000465_gastrointestinal_hemorrhage1.00676774
76MP0005464_abnormal_platelet_physiology0.96524137
77MP0003011_delayed_dark_adaptation0.93715574
78MP0002095_abnormal_skin_pigmentation0.90387730
79MP0001501_abnormal_sleep_pattern0.90171172
80MP0002653_abnormal_ependyma_morphology0.88216662
81MP0001873_stomach_inflammation0.87907246
82MP0005365_abnormal_bile_salt0.87127011
83MP0008007_abnormal_cellular_replicative0.86739502
84MP0008789_abnormal_olfactory_epithelium0.86448563
85MP0002006_tumorigenesis0.86282586
86MP0009764_decreased_sensitivity_to0.85652116
87MP0003436_decreased_susceptibility_to0.84975417
88MP0002139_abnormal_hepatobiliary_system0.83654181
89MP0001905_abnormal_dopamine_level0.83220799
90MP0001986_abnormal_taste_sensitivity0.82690382
91MP0004142_abnormal_muscle_tone0.81204115
92MP0002019_abnormal_tumor_incidence0.79442021
93MP0002163_abnormal_gland_morphology0.78516364
94MP0002735_abnormal_chemical_nociception0.77775461
95MP0002693_abnormal_pancreas_physiology0.77631310
96MP0005319_abnormal_enzyme/_coenzyme0.76078184
97MP0004885_abnormal_endolymph0.73981904
98MP0009643_abnormal_urine_homeostasis0.73630316
99MP0005389_reproductive_system_phenotype0.73365832
100MP0005253_abnormal_eye_physiology0.71542719

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.44188724
2Acute necrotizing encephalopathy (HP:0006965)4.15090606
3Abnormality of B cell number (HP:0010975)4.04036547
4Severe combined immunodeficiency (HP:0004430)4.03498708
5Mitochondrial inheritance (HP:0001427)3.97155457
6Abnormal mitochondria in muscle tissue (HP:0008316)3.90606965
7Hypoproteinemia (HP:0003075)3.86972276
8Hepatocellular necrosis (HP:0001404)3.76354169
9Acute encephalopathy (HP:0006846)3.76278662
10Abnormality of T cell number (HP:0011839)3.75540474
11Increased CSF lactate (HP:0002490)3.60975112
12Hepatic necrosis (HP:0002605)3.55265837
13Eosinophilia (HP:0001880)3.42855604
14Cerebral edema (HP:0002181)3.42740222
15Progressive macrocephaly (HP:0004481)3.38852102
16Panhypogammaglobulinemia (HP:0003139)3.38033210
17Autoimmune hemolytic anemia (HP:0001890)3.36143830
18T lymphocytopenia (HP:0005403)3.27370752
19Abnormality of eosinophils (HP:0001879)3.23840485
20Autoimmune thrombocytopenia (HP:0001973)3.15588569
21Combined immunodeficiency (HP:0005387)3.14337477
22IgG deficiency (HP:0004315)3.00873565
23Thyroiditis (HP:0100646)2.99371993
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.87587298
25B lymphocytopenia (HP:0010976)2.85200286
26Granulocytopenia (HP:0001913)2.84429976
27Oral leukoplakia (HP:0002745)2.83460406
28Increased IgM level (HP:0003496)2.79128655
293-Methylglutaconic aciduria (HP:0003535)2.75887941
30Congenital stationary night blindness (HP:0007642)2.73598318
31Increased hepatocellular lipid droplets (HP:0006565)2.71783422
32Abnormality of T cells (HP:0002843)2.71177718
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.65459396
34Pancytopenia (HP:0001876)2.61185764
35Increased serum lactate (HP:0002151)2.59165327
36Lactic acidosis (HP:0003128)2.57346847
37Optic disc pallor (HP:0000543)2.55596912
38Stomach cancer (HP:0012126)2.54668270
39Abnormality of the prostate (HP:0008775)2.54387932
40Increased intramyocellular lipid droplets (HP:0012240)2.54120439
41Elevated erythrocyte sedimentation rate (HP:0003565)2.53788384
42Generalized aminoaciduria (HP:0002909)2.53440595
43Hypoplasia of the thymus (HP:0000778)2.49592928
44Lipid accumulation in hepatocytes (HP:0006561)2.48464493
45Abolished electroretinogram (ERG) (HP:0000550)2.40288599
46Lethargy (HP:0001254)2.39339874
47Methylmalonic acidemia (HP:0002912)2.39314255
48Hyperglycinuria (HP:0003108)2.37748032
49Constricted visual fields (HP:0001133)2.36938962
50Type I transferrin isoform profile (HP:0003642)2.36847251
51Reduced antithrombin III activity (HP:0001976)2.36634440
52Respiratory failure (HP:0002878)2.34160461
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32941515
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32941515
55Pancreatic cysts (HP:0001737)2.29303059
56Attenuation of retinal blood vessels (HP:0007843)2.28487613
57Methylmalonic aciduria (HP:0012120)2.24680345
58Renal Fanconi syndrome (HP:0001994)2.23055513
59Abnormality of glycine metabolism (HP:0010895)2.21130146
60Abnormality of serine family amino acid metabolism (HP:0010894)2.21130146
61True hermaphroditism (HP:0010459)2.20896012
62Agammaglobulinemia (HP:0004432)2.20713638
63Congenital, generalized hypertrichosis (HP:0004540)2.19208801
64Decreased central vision (HP:0007663)2.12239799
65Leukocytosis (HP:0001974)2.12066945
66Stomatitis (HP:0010280)2.09761508
67Chronic diarrhea (HP:0002028)2.09746737
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09186455
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02598424
70Increased muscle lipid content (HP:0009058)2.02364459
71Abnormality of T cell physiology (HP:0011840)2.01297330
72CNS demyelination (HP:0007305)1.98815970
73Dry hair (HP:0011359)1.98211591
74Hyperglycinemia (HP:0002154)1.95850990
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95633202
76Dicarboxylic aciduria (HP:0003215)1.95633202
77Encephalitis (HP:0002383)1.93850323
78Abnormal protein glycosylation (HP:0012346)1.93083575
79Abnormal glycosylation (HP:0012345)1.93083575
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93083575
81Abnormal protein N-linked glycosylation (HP:0012347)1.93083575
82Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92939813
83Abnormal rod and cone electroretinograms (HP:0008323)1.90343000
84Exercise intolerance (HP:0003546)1.89318036
85Colon cancer (HP:0003003)1.86435583
86Renal cortical cysts (HP:0000803)1.82473299
87Abnormality of methionine metabolism (HP:0010901)1.80898013
88Pancreatic fibrosis (HP:0100732)1.79730588
89Meningitis (HP:0001287)1.78767584
90Abnormality of urine glucose concentration (HP:0011016)1.77134628
91Glycosuria (HP:0003076)1.77134628
92Abnormality of serum amino acid levels (HP:0003112)1.76924252
93Neutropenia (HP:0001875)1.74922337
94Erythroderma (HP:0001019)1.74798586
95Abnormality of the vitamin B12 metabolism (HP:0004341)1.71940847
96Pendular nystagmus (HP:0012043)1.67432693
97Retrobulbar optic neuritis (HP:0100654)1.67175412
98Optic neuritis (HP:0100653)1.67175412
99Leukodystrophy (HP:0002415)1.66582297
100Chronic sinusitis (HP:0011109)1.65591956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.51089868
2TXK3.40644318
3KDR3.27807801
4BUB13.21526384
5BCKDK3.19799069
6TESK22.51666427
7MAP3K122.46909067
8STK162.43925708
9MAP4K22.43736714
10EIF2AK32.30396470
11TIE12.29187056
12PINK12.05079791
13MST41.94405141
14GRK11.91373092
15MAP4K11.78299637
16NUAK11.78112332
17PIK3CG1.73938460
18FES1.72740383
19MAP3K91.67846944
20SRPK11.60984711
21ITK1.50227703
22SCYL21.49530231
23TAF11.49007856
24NEK11.48022961
25TAOK31.41475340
26VRK11.37453597
27ADRBK21.36720702
28PASK1.34784254
29OXSR11.32966274
30TEC1.32502931
31EIF2AK11.24672945
32PBK1.21953215
33CDK191.20844724
34MAP2K71.16321245
35NME11.15046046
36ZAK1.10110360
37LIMK11.03870314
38WNK31.03738740
39DAPK11.01656051
40BCR1.00396978
41CSNK1G30.99280933
42IRAK40.98987729
43MAP3K110.96328383
44TNK20.94810641
45SYK0.93876079
46TESK10.93194405
47STK390.91143248
48IKBKE0.87227279
49GRK70.86693209
50PRKCQ0.85093215
51MAPKAPK30.83247757
52TLK10.81627242
53MYLK0.80492175
54MAP2K60.79717412
55GRK60.78359962
56CSNK1G10.76632251
57LYN0.76000000
58CSNK1G20.74970785
59CSNK1A1L0.73679359
60CDK80.73572829
61MATK0.73096593
62LCK0.71746132
63BMPR1B0.69734507
64BTK0.65679820
65DYRK20.65521998
66CSK0.65438783
67PIM20.65186575
68MUSK0.64077658
69TSSK60.61193892
70ACVR1B0.59220380
71RPS6KA40.59059545
72CCNB10.57347087
73RPS6KA50.56757364
74INSRR0.56462356
75ERBB30.55587590
76WNK40.53910778
77AURKA0.53517519
78CSF1R0.53115778
79TRIM280.52117055
80GRK50.50232035
81KIT0.50038686
82IKBKB0.49596349
83PLK40.47489102
84PLK20.46694550
85CSNK2A10.44229075
86MINK10.43690196
87MARK10.42677073
88ADRBK10.41753749
89IGF1R0.39791340
90PIK3CA0.39066630
91MAPK130.38932380
92PLK10.38445350
93CAMKK20.37415306
94MAP3K50.35952224
95TBK10.35371160
96CSNK2A20.34321131
97PLK30.33968874
98HCK0.33181083
99ATR0.32621353
100AURKB0.31313352

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82710814
2Primary immunodeficiency_Homo sapiens_hsa053403.39806877
3Oxidative phosphorylation_Homo sapiens_hsa001903.19660619
4Parkinsons disease_Homo sapiens_hsa050122.71512912
5Graft-versus-host disease_Homo sapiens_hsa053322.57319445
6Allograft rejection_Homo sapiens_hsa053302.33417160
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28783162
8Protein export_Homo sapiens_hsa030602.17888167
9Type I diabetes mellitus_Homo sapiens_hsa049402.00782212
10Antigen processing and presentation_Homo sapiens_hsa046121.98195303
11RNA polymerase_Homo sapiens_hsa030201.90046432
12Asthma_Homo sapiens_hsa053101.80567384
13Propanoate metabolism_Homo sapiens_hsa006401.77491338
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72733242
15Ribosome_Homo sapiens_hsa030101.70788561
16Alzheimers disease_Homo sapiens_hsa050101.67240876
17Huntingtons disease_Homo sapiens_hsa050161.63431908
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.62459531
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58979348
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58254379
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56548312
22One carbon pool by folate_Homo sapiens_hsa006701.51776583
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51364035
24Hematopoietic cell lineage_Homo sapiens_hsa046401.49458566
25Homologous recombination_Homo sapiens_hsa034401.41957222
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39982457
27Rheumatoid arthritis_Homo sapiens_hsa053231.34695083
28Base excision repair_Homo sapiens_hsa034101.34413861
29Phototransduction_Homo sapiens_hsa047441.31955720
30Sulfur metabolism_Homo sapiens_hsa009201.27573330
31Basal transcription factors_Homo sapiens_hsa030221.26690489
32Pyrimidine metabolism_Homo sapiens_hsa002401.26081573
33DNA replication_Homo sapiens_hsa030301.24862815
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21644232
35Spliceosome_Homo sapiens_hsa030401.20901711
36Nitrogen metabolism_Homo sapiens_hsa009101.16254412
37Mismatch repair_Homo sapiens_hsa034301.14447598
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12099934
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10757176
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07246099
41Peroxisome_Homo sapiens_hsa041461.06264161
42Non-homologous end-joining_Homo sapiens_hsa034501.05107200
43Viral myocarditis_Homo sapiens_hsa054161.03140731
44Tryptophan metabolism_Homo sapiens_hsa003800.99743537
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99483520
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98037609
47Pyruvate metabolism_Homo sapiens_hsa006200.97893735
48RNA degradation_Homo sapiens_hsa030180.97377856
49Linoleic acid metabolism_Homo sapiens_hsa005910.95683279
50Chemical carcinogenesis_Homo sapiens_hsa052040.95383167
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94924637
52Fanconi anemia pathway_Homo sapiens_hsa034600.88373585
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.88246322
54RNA transport_Homo sapiens_hsa030130.85895741
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85606404
56Nucleotide excision repair_Homo sapiens_hsa034200.84458566
57Caffeine metabolism_Homo sapiens_hsa002320.83458393
58Purine metabolism_Homo sapiens_hsa002300.83220950
59Butanoate metabolism_Homo sapiens_hsa006500.82493363
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80938527
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78652817
62Fatty acid elongation_Homo sapiens_hsa000620.77610788
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75590852
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74773979
65Retinol metabolism_Homo sapiens_hsa008300.72930261
66T cell receptor signaling pathway_Homo sapiens_hsa046600.71968665
67Cardiac muscle contraction_Homo sapiens_hsa042600.71579561
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70587733
69Regulation of autophagy_Homo sapiens_hsa041400.69892567
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.69194848
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68670145
72Folate biosynthesis_Homo sapiens_hsa007900.66926372
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66590952
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65915758
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.65111008
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64050126
77Collecting duct acid secretion_Homo sapiens_hsa049660.62634579
78Arachidonic acid metabolism_Homo sapiens_hsa005900.60794491
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60689815
80Metabolic pathways_Homo sapiens_hsa011000.60460521
81Glutathione metabolism_Homo sapiens_hsa004800.59624370
82beta-Alanine metabolism_Homo sapiens_hsa004100.56920070
83Staphylococcus aureus infection_Homo sapiens_hsa051500.56621843
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.55310655
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.51664385
86Systemic lupus erythematosus_Homo sapiens_hsa053220.51302489
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50085279
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49620432
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.43326953
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43166416
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42753919
92Measles_Homo sapiens_hsa051620.40177640
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39515358
94Herpes simplex infection_Homo sapiens_hsa051680.39130841
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37746505
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36485895
97Shigellosis_Homo sapiens_hsa051310.34096242
98Steroid biosynthesis_Homo sapiens_hsa001000.33995863
99Epstein-Barr virus infection_Homo sapiens_hsa051690.33782218
100Sulfur relay system_Homo sapiens_hsa041220.33203769

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