PPIAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.64722919
2response to pheromone (GO:0019236)5.18662620
3DNA deamination (GO:0045006)4.87020010
4positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.79149245
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.57083064
6regulation of isotype switching to IgG isotypes (GO:0048302)4.45970879
7regulation of immunoglobulin secretion (GO:0051023)4.03009542
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.68292799
9protein polyglutamylation (GO:0018095)3.55009078
10protein neddylation (GO:0045116)3.51923284
11protein complex biogenesis (GO:0070271)3.50691208
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47273533
13regulation of mitochondrial translation (GO:0070129)3.41914484
14platelet dense granule organization (GO:0060155)3.39782011
15DNA strand renaturation (GO:0000733)3.38293876
16regulation of chronic inflammatory response (GO:0002676)3.38070707
17mitochondrial respiratory chain complex assembly (GO:0033108)3.38039535
18regulation of cellular amino acid metabolic process (GO:0006521)3.34084817
19DNA double-strand break processing (GO:0000729)3.34004548
20replication fork processing (GO:0031297)3.29944298
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.29538914
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.29538914
23behavioral response to nicotine (GO:0035095)3.26838348
24water-soluble vitamin biosynthetic process (GO:0042364)3.26734702
25cytochrome complex assembly (GO:0017004)3.24553506
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21782282
27sperm motility (GO:0030317)3.18222646
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18064555
29ATP synthesis coupled proton transport (GO:0015986)3.18064555
30ribosomal small subunit assembly (GO:0000028)3.15980069
31resolution of meiotic recombination intermediates (GO:0000712)3.15435636
32negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14975374
33negative regulation of ligase activity (GO:0051352)3.14975374
34maturation of SSU-rRNA (GO:0030490)3.14821230
35chaperone-mediated protein transport (GO:0072321)3.14042458
36regulation of cilium movement (GO:0003352)3.12776548
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12293732
38rRNA modification (GO:0000154)3.11752989
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10571957
40cytidine metabolic process (GO:0046087)3.09416976
41cytidine catabolic process (GO:0006216)3.09416976
42cytidine deamination (GO:0009972)3.09416976
43L-fucose catabolic process (GO:0042355)3.08497244
44fucose catabolic process (GO:0019317)3.08497244
45L-fucose metabolic process (GO:0042354)3.08497244
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00177837
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00177837
48termination of RNA polymerase I transcription (GO:0006363)2.98482479
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98007586
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98007586
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98007586
52GTP biosynthetic process (GO:0006183)2.97270497
53protein deneddylation (GO:0000338)2.94428689
54spliceosomal complex assembly (GO:0000245)2.93962778
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93803341
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93478168
57negative regulation of telomere maintenance (GO:0032205)2.92713449
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.92007578
59sequestering of actin monomers (GO:0042989)2.89503353
60regulation of glycogen (starch) synthase activity (GO:2000465)2.89189725
61nonmotile primary cilium assembly (GO:0035058)2.88904647
62cullin deneddylation (GO:0010388)2.87127041
63respiratory chain complex IV assembly (GO:0008535)2.86377161
64regulation of centriole replication (GO:0046599)2.86306933
65histone exchange (GO:0043486)2.86271292
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84866362
67signal transduction involved in cell cycle checkpoint (GO:0072395)2.84674838
68signal transduction involved in DNA integrity checkpoint (GO:0072401)2.82651399
69signal transduction involved in DNA damage checkpoint (GO:0072422)2.82651399
70intracellular protein transmembrane import (GO:0044743)2.81227809
71positive regulation of prostaglandin secretion (GO:0032308)2.81114804
72proteasome assembly (GO:0043248)2.79648497
73cellular component biogenesis (GO:0044085)2.79299503
74hepatocyte apoptotic process (GO:0097284)2.78638723
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74476720
76positive regulation of organelle assembly (GO:1902117)2.73073860
77transcription elongation from RNA polymerase I promoter (GO:0006362)2.72142305
78microtubule depolymerization (GO:0007019)2.71403092
79rRNA methylation (GO:0031167)2.70266518
80male meiosis I (GO:0007141)2.67318391
81ribosome biogenesis (GO:0042254)2.64942848
82hydrogen ion transmembrane transport (GO:1902600)2.62965024
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60852447
84electron transport chain (GO:0022900)2.60812088
85mitochondrial respiratory chain complex I assembly (GO:0032981)2.59801162
86NADH dehydrogenase complex assembly (GO:0010257)2.59801162
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59801162
88protein localization to peroxisome (GO:0072662)2.59604374
89protein targeting to peroxisome (GO:0006625)2.59604374
90establishment of protein localization to peroxisome (GO:0072663)2.59604374
91ribonucleoprotein complex disassembly (GO:0032988)2.59418223
92respiratory electron transport chain (GO:0022904)2.58905530
93UTP biosynthetic process (GO:0006228)2.58301356
94hypothalamus development (GO:0021854)2.56960021
95guanosine-containing compound biosynthetic process (GO:1901070)2.55448012
96arginine catabolic process (GO:0006527)2.54087292
97somite rostral/caudal axis specification (GO:0032525)2.53164672
98positive regulation of activated T cell proliferation (GO:0042104)2.52845953
99kinetochore assembly (GO:0051382)2.52272801
100organelle disassembly (GO:1903008)2.51366013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.93708849
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.37552856
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.43494483
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41042810
5EZH2_22144423_ChIP-Seq_EOC_Human3.10502495
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91434099
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87250542
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.84683320
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77808788
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.64642856
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61051434
12ZNF274_21170338_ChIP-Seq_K562_Hela2.52375341
13VDR_23849224_ChIP-Seq_CD4+_Human2.43283857
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40355012
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38383253
16VDR_22108803_ChIP-Seq_LS180_Human2.32815583
17ELK1_19687146_ChIP-ChIP_HELA_Human2.30868881
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.19161202
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06922922
20FOXP3_21729870_ChIP-Seq_TREG_Human1.94241562
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.90004849
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86156314
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82757815
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73496612
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73473999
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.68849953
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.68836605
28MYC_18940864_ChIP-ChIP_HL60_Human1.67261240
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66642051
30FUS_26573619_Chip-Seq_HEK293_Human1.65134518
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60347094
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.58344461
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.57632439
34GABP_19822575_ChIP-Seq_HepG2_Human1.53984242
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52463325
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52345355
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47459141
38TTF2_22483619_ChIP-Seq_HELA_Human1.46878045
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41855314
40ER_23166858_ChIP-Seq_MCF-7_Human1.41002694
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39646978
42EWS_26573619_Chip-Seq_HEK293_Human1.39351712
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38237785
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37230059
45TP53_22573176_ChIP-Seq_HFKS_Human1.34546869
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.32367659
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29828076
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29155718
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26947683
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26471132
51SOX2_19829295_ChIP-Seq_ESCs_Human1.25513119
52NANOG_19829295_ChIP-Seq_ESCs_Human1.25513119
53P300_19829295_ChIP-Seq_ESCs_Human1.25477217
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24872090
55XRN2_22483619_ChIP-Seq_HELA_Human1.24505855
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.21924972
57NCOR_22424771_ChIP-Seq_293T_Human1.20477385
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17426244
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16325110
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15292199
61IRF1_19129219_ChIP-ChIP_H3396_Human1.15028625
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12359292
63ERA_21632823_ChIP-Seq_H3396_Human1.12225027
64IGF1R_20145208_ChIP-Seq_DFB_Human1.12026077
65CBP_20019798_ChIP-Seq_JUKART_Human1.11039976
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11039976
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07968960
68AR_20517297_ChIP-Seq_VCAP_Human1.06867737
69MYC_19829295_ChIP-Seq_ESCs_Human1.06015163
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.05567003
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05567003
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05357263
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05309520
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05205638
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04130183
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04079660
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03384746
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02573603
79NANOG_20526341_ChIP-Seq_ESCs_Human1.02341055
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01697627
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01650571
82HOXB7_26014856_ChIP-Seq_BT474_Human0.99753755
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98365210
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98324916
85DCP1A_22483619_ChIP-Seq_HELA_Human0.97022765
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.96905093
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96439228
88P53_21459846_ChIP-Seq_SAOS-2_Human0.96357405
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96338329
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.96112878
91TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95200776
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95019452
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93072510
94RBPJ_21746931_ChIP-Seq_IB4_Human0.92585784
95TAF2_19829295_ChIP-Seq_ESCs_Human0.91950854
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88427412
97KDM5A_27292631_Chip-Seq_BREAST_Human0.86507459
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85899890
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84146712
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83940095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.44585196
2MP0008789_abnormal_olfactory_epithelium2.89372301
3MP0003878_abnormal_ear_physiology2.74946763
4MP0005377_hearing/vestibular/ear_phenot2.74946763
5MP0006292_abnormal_olfactory_placode2.67981688
6MP0003718_maternal_effect2.47000953
7MP0005410_abnormal_fertilization2.46034776
8MP0008872_abnormal_physiological_respon2.38976146
9MP0006072_abnormal_retinal_apoptosis2.31890563
10MP0005084_abnormal_gallbladder_morpholo2.28497425
11MP0008877_abnormal_DNA_methylation2.25429289
12MP0000566_synostosis2.21582004
13MP0005394_taste/olfaction_phenotype2.21170265
14MP0005499_abnormal_olfactory_system2.21170265
15MP0002736_abnormal_nociception_after2.07149231
16MP0008875_abnormal_xenobiotic_pharmacok2.04322078
17MP0001348_abnormal_lacrimal_gland1.96127967
18MP0004142_abnormal_muscle_tone1.94816204
19MP0001968_abnormal_touch/_nociception1.86721879
20MP0003646_muscle_fatigue1.81122201
21MP0008058_abnormal_DNA_repair1.80064991
22MP0004147_increased_porphyrin_level1.74621671
23MP0005645_abnormal_hypothalamus_physiol1.74397859
24MP0003693_abnormal_embryo_hatching1.74330408
25MP0001873_stomach_inflammation1.73719857
26MP0002163_abnormal_gland_morphology1.70911003
27MP0002102_abnormal_ear_morphology1.66521718
28MP0002138_abnormal_hepatobiliary_system1.66370492
29MP0003880_abnormal_central_pattern1.65583199
30MP0003011_delayed_dark_adaptation1.61093637
31MP0003786_premature_aging1.58088502
32MP0001984_abnormal_olfaction1.57020104
33MP0001485_abnormal_pinna_reflex1.53262976
34MP0006054_spinal_hemorrhage1.46870123
35MP0004742_abnormal_vestibular_system1.43417591
36MP0001293_anophthalmia1.43287530
37MP0005551_abnormal_eye_electrophysiolog1.42960400
38MP0005253_abnormal_eye_physiology1.39985020
39MP0006276_abnormal_autonomic_nervous1.38273104
40MP0001919_abnormal_reproductive_system1.33622019
41MP0000015_abnormal_ear_pigmentation1.31696451
42MP0002653_abnormal_ependyma_morphology1.31408168
43MP0002272_abnormal_nervous_system1.30759937
44MP0010094_abnormal_chromosome_stability1.30172323
45MP0004782_abnormal_surfactant_physiolog1.29674073
46MP0002210_abnormal_sex_determination1.28034745
47MP0001835_abnormal_antigen_presentation1.24108686
48MP0003698_abnormal_male_reproductive1.24005410
49MP0001929_abnormal_gametogenesis1.18994290
50MP0002234_abnormal_pharynx_morphology1.18866274
51MP0003122_maternal_imprinting1.13530430
52MP0002822_catalepsy1.09975306
53MP0009745_abnormal_behavioral_response1.07959335
54MP0001188_hyperpigmentation1.07480098
55MP0005379_endocrine/exocrine_gland_phen1.05958968
56MP0005646_abnormal_pituitary_gland1.05099165
57MP0001145_abnormal_male_reproductive1.04494327
58MP0001986_abnormal_taste_sensitivity1.04221805
59MP0000569_abnormal_digit_pigmentation1.03876802
60MP0004885_abnormal_endolymph1.03776775
61MP0003121_genomic_imprinting1.02751089
62MP0009053_abnormal_anal_canal1.02579408
63MP0002184_abnormal_innervation1.01498908
64MP0002095_abnormal_skin_pigmentation1.01299955
65MP0000653_abnormal_sex_gland1.00892242
66MP0004043_abnormal_pH_regulation1.00878432
67MP0000631_abnormal_neuroendocrine_gland0.99769722
68MP0001501_abnormal_sleep_pattern0.99649190
69MP0005395_other_phenotype0.99614875
70MP0005389_reproductive_system_phenotype0.99129742
71MP0005310_abnormal_salivary_gland0.98312356
72MP0006035_abnormal_mitochondrial_morpho0.97590536
73MP0008932_abnormal_embryonic_tissue0.96740724
74MP0000049_abnormal_middle_ear0.94270451
75MP0005075_abnormal_melanosome_morpholog0.93065236
76MP0005408_hypopigmentation0.92899482
77MP0004957_abnormal_blastocyst_morpholog0.92737311
78MP0000427_abnormal_hair_cycle0.92712152
79MP0003787_abnormal_imprinting0.92640684
80MP0001853_heart_inflammation0.91156513
81MP0002557_abnormal_social/conspecific_i0.90853389
82MP0003567_abnormal_fetal_cardiomyocyte0.88845283
83MP0002938_white_spotting0.88268474
84MP0005167_abnormal_blood-brain_barrier0.84635635
85MP0005083_abnormal_biliary_tract0.84239512
86MP0001119_abnormal_female_reproductive0.83783927
87MP0001905_abnormal_dopamine_level0.83140584
88MP0005670_abnormal_white_adipose0.82838987
89MP0001486_abnormal_startle_reflex0.81554636
90MP0003866_abnormal_defecation0.80985029
91MP0005387_immune_system_phenotype0.78154355
92MP0001790_abnormal_immune_system0.78154355
93MP0008007_abnormal_cellular_replicative0.77045281
94MP0002572_abnormal_emotion/affect_behav0.76865087
95MP0002067_abnormal_sensory_capabilities0.76038464
96MP0009785_altered_susceptibility_to0.75000371
97MP0005195_abnormal_posterior_eye0.74325499
98MP0005636_abnormal_mineral_homeostasis0.72077197
99MP0001765_abnormal_ion_homeostasis0.71223065
100MP0002752_abnormal_somatic_nervous0.71093063

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.46492064
2Lipid accumulation in hepatocytes (HP:0006561)4.05887732
3Renal Fanconi syndrome (HP:0001994)3.91102854
4Mitochondrial inheritance (HP:0001427)3.90790353
5Acute necrotizing encephalopathy (HP:0006965)3.61876169
6Increased CSF lactate (HP:0002490)3.50192970
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.27237432
8Pancreatic fibrosis (HP:0100732)3.25279483
9Hepatocellular necrosis (HP:0001404)3.23775973
10Abnormality of the labia minora (HP:0012880)3.22412944
11Chronic hepatic failure (HP:0100626)3.17403920
12Acute encephalopathy (HP:0006846)3.12686883
13Abnormal mitochondria in muscle tissue (HP:0008316)3.05857528
14Pendular nystagmus (HP:0012043)3.02004749
15Type II lissencephaly (HP:0007260)2.99707171
16Pancreatic cysts (HP:0001737)2.91176026
17Molar tooth sign on MRI (HP:0002419)2.88224410
18Abnormality of midbrain morphology (HP:0002418)2.88224410
19Nephronophthisis (HP:0000090)2.83171864
20Increased intramyocellular lipid droplets (HP:0012240)2.82459474
21Progressive macrocephaly (HP:0004481)2.81048013
22True hermaphroditism (HP:0010459)2.79614194
23Congenital stationary night blindness (HP:0007642)2.77302078
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75088305
25Hepatic necrosis (HP:0002605)2.67812261
26Hyperglycinemia (HP:0002154)2.62341832
27Abnormal rod and cone electroretinograms (HP:0008323)2.62178693
28Exertional dyspnea (HP:0002875)2.57914313
29Type 2 muscle fiber atrophy (HP:0003554)2.57404669
30Increased serum lactate (HP:0002151)2.53644409
31Abnormality of the aortic arch (HP:0012303)2.50262482
32Methylmalonic aciduria (HP:0012120)2.49244920
33Medial flaring of the eyebrow (HP:0010747)2.46456318
34Rib fusion (HP:0000902)2.43171774
35Abnormality of renal resorption (HP:0011038)2.38653806
36Abnormal biliary tract physiology (HP:0012439)2.36639549
37Bile duct proliferation (HP:0001408)2.36639549
38Bony spicule pigmentary retinopathy (HP:0007737)2.35888364
39Methylmalonic acidemia (HP:0002912)2.34429111
40Severe visual impairment (HP:0001141)2.33882089
41IgG deficiency (HP:0004315)2.33809412
42Respiratory difficulties (HP:0002880)2.33192779
43Gait imbalance (HP:0002141)2.29076991
44Genetic anticipation (HP:0003743)2.25512778
45Abolished electroretinogram (ERG) (HP:0000550)2.25204001
46Muscle fiber atrophy (HP:0100295)2.25012369
47Increased muscle lipid content (HP:0009058)2.24795732
48Cerebral edema (HP:0002181)2.22752366
49Abnormal lung lobation (HP:0002101)2.21636740
50Tubulointerstitial nephritis (HP:0001970)2.21335828
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19598497
52Congenital primary aphakia (HP:0007707)2.17968295
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.17430225
54Abnormality of the renal medulla (HP:0100957)2.16857085
55Optic disc pallor (HP:0000543)2.14837874
56Abnormality of the ileum (HP:0001549)2.13985955
57Lissencephaly (HP:0001339)2.10450028
58Cerebellar dysplasia (HP:0007033)2.09682088
59Colon cancer (HP:0003003)2.08991881
60Tubular atrophy (HP:0000092)2.08758327
61Ectopic kidney (HP:0000086)2.08222560
62Meckel diverticulum (HP:0002245)2.03192487
63Lactic acidosis (HP:0003128)1.99682013
64Postaxial foot polydactyly (HP:0001830)1.99279194
65Oligodactyly (HP:0012165)1.99044733
66Aplasia/Hypoplasia of the uvula (HP:0010293)1.97481645
67Nephrogenic diabetes insipidus (HP:0009806)1.96875894
68Retinal dysplasia (HP:0007973)1.92799149
69Hyperphosphaturia (HP:0003109)1.92584521
70Pancytopenia (HP:0001876)1.92479470
713-Methylglutaconic aciduria (HP:0003535)1.88924598
72Aplasia/hypoplasia of the uterus (HP:0008684)1.88221670
73Albinism (HP:0001022)1.86526430
74Abnormal respiratory epithelium morphology (HP:0012253)1.86117476
75Abnormal respiratory motile cilium morphology (HP:0005938)1.86117476
76Hypoalbuminemia (HP:0003073)1.83751417
77Abnormal albumin level (HP:0012116)1.83751417
78Microvesicular hepatic steatosis (HP:0001414)1.82055264
79Agitation (HP:0000713)1.81417248
80Progressive cerebellar ataxia (HP:0002073)1.81186366
81Emotional lability (HP:0000712)1.77672255
82Hypoplasia of the uterus (HP:0000013)1.77091280
83Asplenia (HP:0001746)1.76207185
84Carpal bone hypoplasia (HP:0001498)1.75628091
85Cystic liver disease (HP:0006706)1.75396901
86Supernumerary spleens (HP:0009799)1.74508710
87Thyroid-stimulating hormone excess (HP:0002925)1.74136497
88Brushfield spots (HP:0001088)1.72225202
89Abnormality of the pons (HP:0007361)1.71499194
90Horseshoe kidney (HP:0000085)1.71337785
91Exercise intolerance (HP:0003546)1.71325394
92Absent thumb (HP:0009777)1.71031332
93Intestinal atresia (HP:0011100)1.70073883
94Failure to thrive in infancy (HP:0001531)1.69022310
95Narrow forehead (HP:0000341)1.68826551
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.68078629
97Lethargy (HP:0001254)1.68014164
98Severe combined immunodeficiency (HP:0004430)1.65713671
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.65348689
100Absent/shortened dynein arms (HP:0200106)1.65348689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK13.57355100
2PLK43.53759121
3EIF2AK33.31423755
4VRK23.15401110
5EIF2AK12.94457245
6MAP4K22.88784043
7TXK2.59780406
8SRPK12.39828738
9ADRBK22.37328112
10TSSK62.19648197
11WNK42.18580654
12PBK2.12283427
13TRIM281.89229947
14BCKDK1.85911274
15DYRK21.78878715
16BUB11.77470514
17NUAK11.71418485
18VRK11.68602384
19NME11.68006048
20MST41.60210682
21EPHB21.59087525
22BCR1.57073678
23PLK31.51446381
24WNK31.48921130
25TAOK31.48088280
26PAK31.46900315
27MKNK21.46030351
28GRK11.45328320
29CSNK1G31.44659668
30PLK21.34696348
31PRKD31.30785729
32CSNK1G21.23308200
33TAF11.22957700
34WEE11.22905455
35SIK31.19566914
36LIMK11.13930322
37CSNK1A1L1.09022489
38STK391.08860844
39PINK11.07200706
40MINK11.05859167
41AKT31.02868188
42NEK11.02121882
43CSNK1G11.00476691
44ERBB30.98445433
45MAP2K70.96532919
46TLK10.94840518
47KDR0.92561604
48MAPK130.92445056
49MAP3K40.91624424
50CDK80.90584703
51MKNK10.87847191
52PRKCG0.87728477
53INSRR0.85970275
54MAP3K90.85334562
55TESK20.83974338
56OXSR10.79419405
57NEK20.77294553
58WNK10.75829177
59PAK60.72006883
60PLK10.67975225
61FRK0.66996088
62EIF2AK20.66712343
63AURKB0.63514276
64PDK20.57796219
65KSR10.54478058
66ZAK0.51661316
67CSNK2A20.50915820
68PRKCQ0.50841088
69RAF10.50721383
70CSNK1A10.50216635
71ATR0.50017913
72BRSK20.49962842
73IKBKB0.49892833
74STK40.48853876
75CAMKK20.47787909
76CSNK2A10.47270900
77DAPK10.45220761
78MARK10.44937596
79BRAF0.42947097
80PHKG20.41244820
81PHKG10.41244820
82CHEK20.40921679
83TIE10.39420887
84CSNK1E0.37728228
85CAMK2A0.35570804
86STK160.34641809
87AURKA0.33657225
88CDK140.33188637
89IKBKE0.29515297
90TYRO30.27845293
91PRKACA0.27497449
92STK380.27451286
93PRKCB0.25259857
94TTK0.24756143
95PRKCD0.22729250
96MAPKAPK30.21378595
97ATM0.20821926
98DYRK30.19965903
99IRAK40.19770981
100MAP3K80.17333961

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82315028
2Oxidative phosphorylation_Homo sapiens_hsa001903.39268409
3Protein export_Homo sapiens_hsa030603.26953083
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88796241
5RNA polymerase_Homo sapiens_hsa030202.88787263
6Parkinsons disease_Homo sapiens_hsa050122.86743839
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46236679
8Ribosome_Homo sapiens_hsa030102.37696703
9Homologous recombination_Homo sapiens_hsa034402.26910407
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19166348
11RNA transport_Homo sapiens_hsa030132.18274651
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10642831
13Fanconi anemia pathway_Homo sapiens_hsa034602.01987645
14Alzheimers disease_Homo sapiens_hsa050101.98997627
15Huntingtons disease_Homo sapiens_hsa050161.94371627
16Basal transcription factors_Homo sapiens_hsa030221.94068453
17Nucleotide excision repair_Homo sapiens_hsa034201.90613013
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81646967
19Mismatch repair_Homo sapiens_hsa034301.74331599
20One carbon pool by folate_Homo sapiens_hsa006701.74158833
21Propanoate metabolism_Homo sapiens_hsa006401.67093409
22Steroid biosynthesis_Homo sapiens_hsa001001.59954067
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57905385
24RNA degradation_Homo sapiens_hsa030181.54983984
25DNA replication_Homo sapiens_hsa030301.54140990
26Cardiac muscle contraction_Homo sapiens_hsa042601.53421995
27Autoimmune thyroid disease_Homo sapiens_hsa053201.50375458
28Spliceosome_Homo sapiens_hsa030401.43044910
29Sulfur metabolism_Homo sapiens_hsa009201.38116340
30Pyrimidine metabolism_Homo sapiens_hsa002401.36565783
31Allograft rejection_Homo sapiens_hsa053301.36246424
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28209140
33Nitrogen metabolism_Homo sapiens_hsa009101.24524812
34Linoleic acid metabolism_Homo sapiens_hsa005911.23367249
35Phototransduction_Homo sapiens_hsa047441.19898337
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19155764
37Asthma_Homo sapiens_hsa053101.14690710
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14306675
39Base excision repair_Homo sapiens_hsa034101.13519941
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08222965
41Peroxisome_Homo sapiens_hsa041461.05794009
42Butanoate metabolism_Homo sapiens_hsa006501.01321829
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98039247
44Nicotine addiction_Homo sapiens_hsa050330.98007897
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.96264207
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95123051
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94318206
48Purine metabolism_Homo sapiens_hsa002300.93565147
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92663598
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89583782
51Antigen processing and presentation_Homo sapiens_hsa046120.83790668
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82628450
53Fatty acid biosynthesis_Homo sapiens_hsa000610.80882235
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78403321
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77486709
56Tryptophan metabolism_Homo sapiens_hsa003800.77065908
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75579028
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72386213
59Primary immunodeficiency_Homo sapiens_hsa053400.71893785
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70623781
61Metabolic pathways_Homo sapiens_hsa011000.67223917
62Type I diabetes mellitus_Homo sapiens_hsa049400.65046019
63Caffeine metabolism_Homo sapiens_hsa002320.60188540
64GABAergic synapse_Homo sapiens_hsa047270.58887255
65Non-homologous end-joining_Homo sapiens_hsa034500.57628708
66T cell receptor signaling pathway_Homo sapiens_hsa046600.57019435
67Oocyte meiosis_Homo sapiens_hsa041140.56537832
68mRNA surveillance pathway_Homo sapiens_hsa030150.56155926
69Fat digestion and absorption_Homo sapiens_hsa049750.54229998
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54189336
71Olfactory transduction_Homo sapiens_hsa047400.53243985
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52384018
73Graft-versus-host disease_Homo sapiens_hsa053320.52113596
74Retinol metabolism_Homo sapiens_hsa008300.50690641
75Ether lipid metabolism_Homo sapiens_hsa005650.50551576
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50540433
77Hematopoietic cell lineage_Homo sapiens_hsa046400.49083036
78Arachidonic acid metabolism_Homo sapiens_hsa005900.47978873
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47970662
80Taste transduction_Homo sapiens_hsa047420.44193816
81Morphine addiction_Homo sapiens_hsa050320.41564365
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.37623814
83Epstein-Barr virus infection_Homo sapiens_hsa051690.36565644
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35541942
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.34029345
86Fatty acid degradation_Homo sapiens_hsa000710.33761575
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.28404501
88Mineral absorption_Homo sapiens_hsa049780.28302739
89Pyruvate metabolism_Homo sapiens_hsa006200.28152745
90Measles_Homo sapiens_hsa051620.27636253
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.25624401
92Cell cycle_Homo sapiens_hsa041100.25563504
93Rheumatoid arthritis_Homo sapiens_hsa053230.25051119
94Chemical carcinogenesis_Homo sapiens_hsa052040.24679861
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24400611
96Vitamin B6 metabolism_Homo sapiens_hsa007500.22435545
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22370696
98Glycerolipid metabolism_Homo sapiens_hsa005610.21851508
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20708810
100Regulation of autophagy_Homo sapiens_hsa041400.19793611

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