PPIAP30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.91677777
2pyrimidine nucleobase catabolic process (GO:0006208)7.76683602
3regulation of retinoic acid receptor signaling pathway (GO:0048385)7.46887219
4nucleobase catabolic process (GO:0046113)6.26327183
5cobalamin metabolic process (GO:0009235)6.20380625
6resolution of meiotic recombination intermediates (GO:0000712)4.86892590
7regulation of isotype switching to IgG isotypes (GO:0048302)4.70805550
8cytokine biosynthetic process (GO:0042089)4.46532312
9detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.34961890
10replication fork processing (GO:0031297)4.21620592
11maturation of 5.8S rRNA (GO:0000460)4.17316603
12detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.10848906
13import into cell (GO:0098657)3.94174289
14intra-S DNA damage checkpoint (GO:0031573)3.90767615
15water-soluble vitamin biosynthetic process (GO:0042364)3.90000199
16cell wall macromolecule metabolic process (GO:0044036)3.82670123
17cerebral cortex radially oriented cell migration (GO:0021799)3.80019689
18DNA excision (GO:0044349)3.75988590
19nucleotide-excision repair, DNA damage removal (GO:0000718)3.75988590
20DNA double-strand break processing (GO:0000729)3.74007873
21positive regulation of amino acid transport (GO:0051957)3.69395055
22cytokine metabolic process (GO:0042107)3.59655888
23central nervous system projection neuron axonogenesis (GO:0021952)3.59558786
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56525331
25presynaptic membrane assembly (GO:0097105)3.55020026
26glucosamine-containing compound catabolic process (GO:1901072)3.54514817
27positive regulation of DNA recombination (GO:0045911)3.50024223
28negative regulation of astrocyte differentiation (GO:0048712)3.47834305
29behavioral response to nicotine (GO:0035095)3.46682304
30positive regulation of alpha-beta T cell proliferation (GO:0046641)3.42317012
31protein K11-linked deubiquitination (GO:0035871)3.39694428
32viral mRNA export from host cell nucleus (GO:0046784)3.37306998
33olfactory bulb development (GO:0021772)3.27476656
34peroxisome fission (GO:0016559)3.25552602
35synaptic transmission, cholinergic (GO:0007271)3.16775000
36sulfation (GO:0051923)3.14470129
37sensory perception of taste (GO:0050909)3.12689550
38cell migration in hindbrain (GO:0021535)3.11114062
39negative regulation of telomere maintenance (GO:0032205)3.05602681
40base-excision repair, AP site formation (GO:0006285)3.01147501
41negative regulation of JAK-STAT cascade (GO:0046426)3.00471747
42cellular response to interferon-beta (GO:0035458)3.00379725
43regulation of acrosome reaction (GO:0060046)3.00234505
44protein complex biogenesis (GO:0070271)2.99361736
45platelet dense granule organization (GO:0060155)2.98536986
46mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95816054
47positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95816054
48digestion (GO:0007586)2.93928624
49positive regulation of granulocyte differentiation (GO:0030854)2.93689268
50maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91121014
51pseudouridine synthesis (GO:0001522)2.89560954
52negative regulation of activin receptor signaling pathway (GO:0032926)2.89249441
53positive regulation of vesicle fusion (GO:0031340)2.86488266
54transcription elongation from RNA polymerase I promoter (GO:0006362)2.85419203
55mitochondrial respiratory chain complex assembly (GO:0033108)2.83515253
56estrogen biosynthetic process (GO:0006703)2.83433221
57positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.81918827
58presynaptic membrane organization (GO:0097090)2.79691800
59phosphatidylinositol acyl-chain remodeling (GO:0036149)2.78585044
60protein K11-linked ubiquitination (GO:0070979)2.77685772
61positive regulation of mitochondrial fission (GO:0090141)2.74042322
62positive regulation of chemokine secretion (GO:0090197)2.73227426
63regulation of glutamate secretion (GO:0014048)2.71005143
64termination of RNA polymerase I transcription (GO:0006363)2.69708550
65alternative mRNA splicing, via spliceosome (GO:0000380)2.67560162
66RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66643637
67positive regulation of viral genome replication (GO:0045070)2.66399708
68positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.66397545
69regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.66397545
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63910060
71mitochondrial respiratory chain complex I assembly (GO:0032981)2.63910060
72NADH dehydrogenase complex assembly (GO:0010257)2.63910060
73histone H4-K12 acetylation (GO:0043983)2.63622134
74positive regulation of organic acid transport (GO:0032892)2.63312100
75positive regulation of isotype switching (GO:0045830)2.63171504
76regulation of alpha-beta T cell proliferation (GO:0046640)2.59056883
77regulation of posttranscriptional gene silencing (GO:0060147)2.59019846
78regulation of gene silencing by miRNA (GO:0060964)2.59019846
79regulation of gene silencing by RNA (GO:0060966)2.59019846
80somite development (GO:0061053)2.58920153
81regulation of telomere maintenance (GO:0032204)2.57107077
82detection of light stimulus involved in visual perception (GO:0050908)2.56141981
83detection of light stimulus involved in sensory perception (GO:0050962)2.56141981
84fucose catabolic process (GO:0019317)2.53948489
85L-fucose metabolic process (GO:0042354)2.53948489
86L-fucose catabolic process (GO:0042355)2.53948489
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53894859
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53894859
89central nervous system neuron axonogenesis (GO:0021955)2.53554730
90endoderm formation (GO:0001706)2.52257025
91respiratory chain complex IV assembly (GO:0008535)2.51743622
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51701142
93cornea development in camera-type eye (GO:0061303)2.51468423
94positive regulation of interleukin-1 beta secretion (GO:0050718)2.50106360
95regulation of cellular amino acid metabolic process (GO:0006521)2.48772042
96glycosphingolipid biosynthetic process (GO:0006688)2.48292478
97ether lipid metabolic process (GO:0046485)2.48270507
98DNA deamination (GO:0045006)2.48183124
99protein polyglutamylation (GO:0018095)2.47130764
100response to prostaglandin E (GO:0034695)2.46028351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.55587667
2ZNF274_21170338_ChIP-Seq_K562_Hela3.26412176
3IGF1R_20145208_ChIP-Seq_DFB_Human3.04199959
4GBX2_23144817_ChIP-Seq_PC3_Human2.61972900
5EZH2_22144423_ChIP-Seq_EOC_Human2.59389311
6VDR_22108803_ChIP-Seq_LS180_Human2.56887999
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54417688
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53097168
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52904088
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41223987
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39721269
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.33082377
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33023894
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.26305168
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21373698
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.16903320
17ELK1_19687146_ChIP-ChIP_HELA_Human2.07807687
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.03742000
19ER_23166858_ChIP-Seq_MCF-7_Human2.00737745
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97274749
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97025620
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93944348
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.92509772
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92275718
25MYC_18940864_ChIP-ChIP_HL60_Human1.92081692
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89221501
27IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82137033
28CBP_20019798_ChIP-Seq_JUKART_Human1.82137033
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75448924
30VDR_23849224_ChIP-Seq_CD4+_Human1.67118063
31P300_19829295_ChIP-Seq_ESCs_Human1.65113613
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64922950
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61436619
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58393014
35RNF2_27304074_Chip-Seq_NSC_Mouse1.53364069
36NCOR_22424771_ChIP-Seq_293T_Human1.50670000
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48686161
38EWS_26573619_Chip-Seq_HEK293_Human1.47577257
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.46967892
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.46553713
41FUS_26573619_Chip-Seq_HEK293_Human1.46404758
42SMAD4_21799915_ChIP-Seq_A2780_Human1.44034668
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.41842373
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41042782
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39852391
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39848443
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39522041
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38049007
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35283210
50BCAT_22108803_ChIP-Seq_LS180_Human1.31350720
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29275510
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28781831
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28660268
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.28633839
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28616621
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28616621
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26514543
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26396148
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.21355698
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20795736
61AR_21572438_ChIP-Seq_LNCaP_Human1.18990248
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18480776
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18030036
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17963788
65REST_21632747_ChIP-Seq_MESCs_Mouse1.17023663
66AR_20517297_ChIP-Seq_VCAP_Human1.16721334
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.12531697
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12446366
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.12132755
70FOXP3_21729870_ChIP-Seq_TREG_Human1.11425459
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11376909
72ETV1_20927104_ChIP-Seq_GIST48_Human1.10427236
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09900183
74STAT3_23295773_ChIP-Seq_U87_Human1.09453850
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08958215
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08737483
77AR_25329375_ChIP-Seq_VCAP_Human1.06995125
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06496804
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06183862
80SOX2_19829295_ChIP-Seq_ESCs_Human1.03761405
81NANOG_19829295_ChIP-Seq_ESCs_Human1.03761405
82RBPJ_21746931_ChIP-Seq_IB4_Human1.01440328
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99252752
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98968023
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98638115
86GATA3_26560356_Chip-Seq_TH2_Human0.97894077
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96719335
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.96449298
89TP53_22573176_ChIP-Seq_HFKS_Human0.95891977
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95141937
91JUN_21703547_ChIP-Seq_K562_Human0.95108476
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94399621
93TAF15_26573619_Chip-Seq_HEK293_Human0.93931156
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93854892
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93772678
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93139761
97PHF8_20622853_ChIP-Seq_HELA_Human0.92289075
98E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91655366
99TBL1_22424771_ChIP-Seq_293T_Human0.91646368
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.91549678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.55779662
2MP0004270_analgesia3.41939365
3MP0002277_abnormal_respiratory_mucosa3.40594089
4MP0004145_abnormal_muscle_electrophysio3.36271520
5MP0002138_abnormal_hepatobiliary_system3.20972793
6MP0005671_abnormal_response_to2.85872504
7MP0006072_abnormal_retinal_apoptosis2.72895790
8MP0001986_abnormal_taste_sensitivity2.39751178
9MP0008872_abnormal_physiological_respon2.29371666
10MP0008875_abnormal_xenobiotic_pharmacok2.29123661
11MP0005253_abnormal_eye_physiology2.04728978
12MP0003195_calcinosis2.01246431
13MP0004147_increased_porphyrin_level1.98946925
14MP0003880_abnormal_central_pattern1.91862499
15MP0002735_abnormal_chemical_nociception1.91034971
16MP0005551_abnormal_eye_electrophysiolog1.90219434
17MP0001188_hyperpigmentation1.72620529
18MP0005083_abnormal_biliary_tract1.66492912
19MP0002095_abnormal_skin_pigmentation1.66207115
20MP0005410_abnormal_fertilization1.64616811
21MP0003646_muscle_fatigue1.64356609
22MP0009840_abnormal_foam_cell1.62661611
23MP0000569_abnormal_digit_pigmentation1.62433106
24MP0002734_abnormal_mechanical_nocicepti1.56577624
25MP0000647_abnormal_sebaceous_gland1.53122666
26MP0000778_abnormal_nervous_system1.52388438
27MP0002876_abnormal_thyroid_physiology1.46964288
28MP0004043_abnormal_pH_regulation1.46551611
29MP0004885_abnormal_endolymph1.44739030
30MP0003718_maternal_effect1.37025998
31MP0005670_abnormal_white_adipose1.34495799
32MP0003959_abnormal_lean_body1.34304105
33MP0005167_abnormal_blood-brain_barrier1.33954490
34MP0005085_abnormal_gallbladder_physiolo1.33784400
35MP0002160_abnormal_reproductive_system1.33582380
36MP0001348_abnormal_lacrimal_gland1.31105493
37MP0003633_abnormal_nervous_system1.29921067
38MP0006276_abnormal_autonomic_nervous1.29479755
39MP0001191_abnormal_skin_condition1.29026393
40MP0008789_abnormal_olfactory_epithelium1.28680908
41MP0003186_abnormal_redox_activity1.28145508
42MP0001873_stomach_inflammation1.27797348
43MP0003635_abnormal_synaptic_transmissio1.27540989
44MP0002184_abnormal_innervation1.26094959
45MP0001919_abnormal_reproductive_system1.24340755
46MP0005645_abnormal_hypothalamus_physiol1.21777277
47MP0002557_abnormal_social/conspecific_i1.19396051
48MP0008995_early_reproductive_senescence1.18488726
49MP0005386_behavior/neurological_phenoty1.15974924
50MP0004924_abnormal_behavior1.15974924
51MP0005499_abnormal_olfactory_system1.14348849
52MP0005394_taste/olfaction_phenotype1.14348849
53MP0001984_abnormal_olfaction1.13929641
54MP0006054_spinal_hemorrhage1.11920014
55MP0000631_abnormal_neuroendocrine_gland1.11917121
56MP0002067_abnormal_sensory_capabilities1.11253284
57MP0003075_altered_response_to1.09915414
58MP0009333_abnormal_splenocyte_physiolog1.06440696
59MP0000427_abnormal_hair_cycle1.05258404
60MP0005389_reproductive_system_phenotype1.04359641
61MP0001764_abnormal_homeostasis1.02946524
62MP0002938_white_spotting1.02352846
63MP0000604_amyloidosis1.00851239
64MP0008877_abnormal_DNA_methylation0.96268900
65MP0003763_abnormal_thymus_physiology0.95718301
66MP0002089_abnormal_postnatal_growth/wei0.95704265
67MP0001968_abnormal_touch/_nociception0.94135146
68MP0003121_genomic_imprinting0.91187076
69MP0001243_abnormal_dermal_layer0.91028275
70MP0000049_abnormal_middle_ear0.89046253
71MP0005501_abnormal_skin_physiology0.88569307
72MP0002752_abnormal_somatic_nervous0.87730912
73MP0002272_abnormal_nervous_system0.87496634
74MP0003631_nervous_system_phenotype0.86763478
75MP0005367_renal/urinary_system_phenotyp0.85296597
76MP0000516_abnormal_urinary_system0.85296597
77MP0002837_dystrophic_cardiac_calcinosis0.84784133
78MP0004142_abnormal_muscle_tone0.84435627
79MP0004742_abnormal_vestibular_system0.83051156
80MP0002234_abnormal_pharynx_morphology0.81200072
81MP0006292_abnormal_olfactory_placode0.79611043
82MP0002693_abnormal_pancreas_physiology0.79239946
83MP0002751_abnormal_autonomic_nervous0.78851750
84MP0002229_neurodegeneration0.78044974
85MP0002063_abnormal_learning/memory/cond0.78038448
86MP0005075_abnormal_melanosome_morpholog0.76640049
87MP0009745_abnormal_behavioral_response0.76470843
88MP0005195_abnormal_posterior_eye0.76096661
89MP0001440_abnormal_grooming_behavior0.75093610
90MP0004811_abnormal_neuron_physiology0.74526763
91MP0001324_abnormal_eye_pigmentation0.74268042
92MP0002177_abnormal_outer_ear0.73911653
93MP0000613_abnormal_salivary_gland0.69840538
94MP0005387_immune_system_phenotype0.69164528
95MP0001790_abnormal_immune_system0.69164528
96MP0001929_abnormal_gametogenesis0.67655710
97MP0002882_abnormal_neuron_morphology0.67133478
98MP0003119_abnormal_digestive_system0.66713550
99MP0001963_abnormal_hearing_physiology0.66168564
100MP0003879_abnormal_hair_cell0.65060801

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of DNA repair (HP:0003254)4.25484651
2Colon cancer (HP:0003003)4.10929994
3Congenital stationary night blindness (HP:0007642)4.03563676
4Type II lissencephaly (HP:0007260)3.99194560
5Lissencephaly (HP:0001339)3.89407790
6Type 2 muscle fiber atrophy (HP:0003554)3.72050002
7Chronic hepatic failure (HP:0100626)3.49963580
8Decreased central vision (HP:0007663)3.29425026
9Molar tooth sign on MRI (HP:0002419)3.13325951
10Abnormality of midbrain morphology (HP:0002418)3.13325951
11Muscle fiber atrophy (HP:0100295)3.11976334
12Spinal muscular atrophy (HP:0007269)3.10773535
13Pancreatic cysts (HP:0001737)2.94415941
14Nephronophthisis (HP:0000090)2.88245886
15Methylmalonic acidemia (HP:0002912)2.84561156
16Retinal dysplasia (HP:0007973)2.80549211
17Attenuation of retinal blood vessels (HP:0007843)2.76842643
18Abnormality of the renal medulla (HP:0100957)2.75757397
19Increased CSF lactate (HP:0002490)2.75404173
20Global brain atrophy (HP:0002283)2.74166744
21Acute necrotizing encephalopathy (HP:0006965)2.69622986
22True hermaphroditism (HP:0010459)2.63455940
23Pachygyria (HP:0001302)2.63411539
24Congenital sensorineural hearing impairment (HP:0008527)2.60201335
25Hypoproteinemia (HP:0003075)2.57825473
26Abnormality of the vitamin B12 metabolism (HP:0004341)2.55503809
27Stomach cancer (HP:0012126)2.53739823
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.53330343
29Mitochondrial inheritance (HP:0001427)2.48396225
30Abnormality of the renal cortex (HP:0011035)2.45321290
31Pancreatic fibrosis (HP:0100732)2.44221661
32Cerebral edema (HP:0002181)2.41027825
33Hepatocellular necrosis (HP:0001404)2.40620360
34Nonprogressive disorder (HP:0003680)2.36954154
35Abnormality of the ileum (HP:0001549)2.33971217
36Abnormality of vitamin B metabolism (HP:0004340)2.32830044
37Congenital, generalized hypertrichosis (HP:0004540)2.30288069
38Prominent metopic ridge (HP:0005487)2.28991836
39Abnormality of the neuromuscular junction (HP:0003398)2.26439662
40Fatigable weakness (HP:0003473)2.26439662
41Meckel diverticulum (HP:0002245)2.26380277
42Progressive macrocephaly (HP:0004481)2.26161411
43Methylmalonic aciduria (HP:0012120)2.24619352
44Abnormal mitochondria in muscle tissue (HP:0008316)2.22597155
45Abnormality of alanine metabolism (HP:0010916)2.21812022
46Hyperalaninemia (HP:0003348)2.21812022
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21812022
48Gaze-evoked nystagmus (HP:0000640)2.21501853
49Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20460329
50Hypoplasia of the brainstem (HP:0002365)2.20460329
51Increased serum lactate (HP:0002151)2.17244333
52Medial flaring of the eyebrow (HP:0010747)2.16938819
53Thickened helices (HP:0000391)2.15280480
54Degeneration of anterior horn cells (HP:0002398)2.14951859
55Abnormality of the anterior horn cell (HP:0006802)2.14951859
56Carpal bone hypoplasia (HP:0001498)2.14363154
57Anhidrosis (HP:0000970)2.10124247
58Decreased muscle mass (HP:0003199)2.09981914
59Aplasia/hypoplasia of the uterus (HP:0008684)2.08967375
60Cerebellar dysplasia (HP:0007033)2.07279319
61Abnormality of the preputium (HP:0100587)2.05272152
62Atrophy/Degeneration involving motor neurons (HP:0007373)2.01460096
63Entropion (HP:0000621)2.00931568
64Increased hepatocellular lipid droplets (HP:0006565)2.00913213
65Abnormality of the metopic suture (HP:0005556)1.99254368
66Nephrogenic diabetes insipidus (HP:0009806)1.99195130
67Submucous cleft hard palate (HP:0000176)1.98456068
68Hypoplasia of the uterus (HP:0000013)1.97553382
69Hypoplasia of the pons (HP:0012110)1.97516811
70Congenital hepatic fibrosis (HP:0002612)1.97274273
71Tubular atrophy (HP:0000092)1.96021524
72Hepatic necrosis (HP:0002605)1.94723420
73Aplastic anemia (HP:0001915)1.94349709
74Truncal obesity (HP:0001956)1.94010683
75Severe muscular hypotonia (HP:0006829)1.90748233
76Anterior segment dysgenesis (HP:0007700)1.89804291
77Abnormality of the pons (HP:0007361)1.87299876
78Acute encephalopathy (HP:0006846)1.87013228
79Abnormality of chromosome stability (HP:0003220)1.86441847
80Abnormal pupillary function (HP:0007686)1.84467405
81Small hand (HP:0200055)1.84140035
82Abnormality of the middle phalanges of the toes (HP:0010183)1.80296232
83Azoospermia (HP:0000027)1.79231600
84Tubulointerstitial nephritis (HP:0001970)1.75870068
853-Methylglutaconic aciduria (HP:0003535)1.74675225
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.74387178
87Hip dysplasia (HP:0001385)1.74015165
88Lipid accumulation in hepatocytes (HP:0006561)1.73958832
89Poikiloderma (HP:0001029)1.73220007
90Lactic acidosis (HP:0003128)1.72441382
91Aplasia/Hypoplasia involving the musculature (HP:0001460)1.72356119
92Gait imbalance (HP:0002141)1.72331267
93Renal Fanconi syndrome (HP:0001994)1.70592220
94Deep palmar crease (HP:0006191)1.68815569
95Steatorrhea (HP:0002570)1.68307168
96Optic nerve coloboma (HP:0000588)1.66944405
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.65273507
98Fibular aplasia (HP:0002990)1.64789434
99Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64120953
100Woolly hair (HP:0002224)1.63981640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.76692165
2TESK25.43664581
3IRAK24.31677733
4IRAK13.59995096
5VRK12.93481957
6MARK12.72503202
7TXK2.50162439
8MAP4K22.29846785
9AKT32.28531657
10RIPK12.25433897
11DYRK22.12742222
12MAPK132.05400527
13EPHB21.98420209
14TIE11.95490860
15VRK21.80101304
16ACVR1B1.78848158
17MAP2K71.59878998
18TAF11.54061326
19DYRK1B1.53665275
20RPS6KB21.46211431
21ZAK1.44245173
22IKBKE1.38625105
23WNK31.12779212
24MAP3K121.11520627
25YES11.10119350
26BCR1.09537046
27PBK1.06499977
28TSSK61.03842109
29ERBB31.00405175
30BMPR1B0.98538984
31TLK10.98463016
32TYK20.96104992
33MAP3K40.94748382
34ADRBK20.92981195
35GRK10.83513403
36FRK0.82385816
37OXSR10.75493384
38PLK30.72742626
39CASK0.67360296
40BUB10.65337439
41PASK0.64958415
42EIF2AK10.64550914
43SGK20.63406345
44TRIM280.61459983
45BRAF0.61011771
46PIK3CG0.59249966
47CAMKK20.58895973
48MAP3K130.56830381
49STK390.56816525
50PAK30.55736371
51EIF2AK30.53649660
52IGF1R0.53207895
53STK240.50854277
54MKNK20.50187149
55EPHA40.48908714
56ITK0.45778001
57NUAK10.44665406
58MKNK10.44539007
59SGK4940.44502427
60SGK2230.44502427
61CDK180.44124859
62STK38L0.41941625
63CDK150.41626290
64PINK10.41393771
65CDK140.41182405
66WNK40.40039845
67GRK70.38882163
68MAP3K90.38625632
69NME10.36898465
70PRKCG0.36490274
71STK30.35592865
72MAP3K60.35519171
73PRKCE0.35208280
74TBK10.33542545
75CDK11A0.33306749
76STK40.32979885
77DYRK1A0.32352948
78SRPK10.32169574
79CSNK1A10.30712568
80IKBKB0.30565409
81DAPK10.29534252
82CDK50.29224130
83INSRR0.29120717
84NEK10.28807082
85ARAF0.28388269
86GSK3A0.28352230
87LIMK10.27663945
88PLK10.27492497
89NTRK20.26646328
90PRKCH0.25842028
91TEC0.25838782
92ATR0.23893691
93CDK80.23835504
94SGK10.23614308
95ADRBK10.22702011
96NTRK10.22621916
97SGK30.21639057
98TGFBR10.21144201
99PLK20.20895485
100AURKA0.20620518

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.39074282
2Proteasome_Homo sapiens_hsa030503.17191478
3Fanconi anemia pathway_Homo sapiens_hsa034602.67730364
4RNA polymerase_Homo sapiens_hsa030202.38694097
5RNA degradation_Homo sapiens_hsa030182.35173759
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.21403010
7Systemic lupus erythematosus_Homo sapiens_hsa053222.19756500
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.14593248
9Oxidative phosphorylation_Homo sapiens_hsa001902.13177177
10Allograft rejection_Homo sapiens_hsa053302.12453266
11Linoleic acid metabolism_Homo sapiens_hsa005912.11513624
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.02708005
13Autoimmune thyroid disease_Homo sapiens_hsa053201.99707132
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.96684683
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92871033
16Taste transduction_Homo sapiens_hsa047421.87058030
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87048652
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82297112
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79044980
20Propanoate metabolism_Homo sapiens_hsa006401.77463034
21Phototransduction_Homo sapiens_hsa047441.76166760
22Protein export_Homo sapiens_hsa030601.72944370
23Nucleotide excision repair_Homo sapiens_hsa034201.69775852
24Primary immunodeficiency_Homo sapiens_hsa053401.64563497
25Parkinsons disease_Homo sapiens_hsa050121.56757000
26Asthma_Homo sapiens_hsa053101.51519325
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.46598896
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43549577
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39044866
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37745497
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34907948
32Nicotine addiction_Homo sapiens_hsa050331.32834745
33Homologous recombination_Homo sapiens_hsa034401.32598767
34Alcoholism_Homo sapiens_hsa050341.31427550
35RNA transport_Homo sapiens_hsa030131.30091695
36Ether lipid metabolism_Homo sapiens_hsa005651.25196047
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19500182
38Steroid biosynthesis_Homo sapiens_hsa001001.17750761
39Pyruvate metabolism_Homo sapiens_hsa006201.15562114
40Regulation of autophagy_Homo sapiens_hsa041401.11404344
41Huntingtons disease_Homo sapiens_hsa050161.10180016
42Nitrogen metabolism_Homo sapiens_hsa009101.09811766
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06983880
44Protein digestion and absorption_Homo sapiens_hsa049741.06781683
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03122330
46Tryptophan metabolism_Homo sapiens_hsa003801.01817693
47Pyrimidine metabolism_Homo sapiens_hsa002401.01547091
48Olfactory transduction_Homo sapiens_hsa047400.99631791
49Fatty acid elongation_Homo sapiens_hsa000620.98766422
50Peroxisome_Homo sapiens_hsa041460.98095722
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.95318948
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92059941
53Retinol metabolism_Homo sapiens_hsa008300.91658564
54Sulfur metabolism_Homo sapiens_hsa009200.91612563
55Alzheimers disease_Homo sapiens_hsa050100.90056252
56Ovarian steroidogenesis_Homo sapiens_hsa049130.88880712
57Graft-versus-host disease_Homo sapiens_hsa053320.83782941
58Type I diabetes mellitus_Homo sapiens_hsa049400.83091309
59Butanoate metabolism_Homo sapiens_hsa006500.77474512
60beta-Alanine metabolism_Homo sapiens_hsa004100.77409762
61Spliceosome_Homo sapiens_hsa030400.74746558
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73287311
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.72812595
64Dorso-ventral axis formation_Homo sapiens_hsa043200.72279110
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69986207
66Non-homologous end-joining_Homo sapiens_hsa034500.69498905
67ABC transporters_Homo sapiens_hsa020100.64475790
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64350053
69Caffeine metabolism_Homo sapiens_hsa002320.62571464
70Hematopoietic cell lineage_Homo sapiens_hsa046400.61676782
71Purine metabolism_Homo sapiens_hsa002300.59937539
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58749678
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58071801
74Dopaminergic synapse_Homo sapiens_hsa047280.54787628
75Viral carcinogenesis_Homo sapiens_hsa052030.54278098
76Fat digestion and absorption_Homo sapiens_hsa049750.53074021
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52779592
78mRNA surveillance pathway_Homo sapiens_hsa030150.52590256
79Cardiac muscle contraction_Homo sapiens_hsa042600.51598730
80Pancreatic secretion_Homo sapiens_hsa049720.50845673
81Glycerolipid metabolism_Homo sapiens_hsa005610.49927768
82Histidine metabolism_Homo sapiens_hsa003400.49111674
83Metabolic pathways_Homo sapiens_hsa011000.48280192
84Arachidonic acid metabolism_Homo sapiens_hsa005900.47822889
85T cell receptor signaling pathway_Homo sapiens_hsa046600.44415015
86Glutamatergic synapse_Homo sapiens_hsa047240.43909161
87Rheumatoid arthritis_Homo sapiens_hsa053230.42768351
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42248684
89Fatty acid metabolism_Homo sapiens_hsa012120.41128671
90Ribosome_Homo sapiens_hsa030100.39812620
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.39374102
92Measles_Homo sapiens_hsa051620.38011453
93Morphine addiction_Homo sapiens_hsa050320.37430540
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37170048
95Epstein-Barr virus infection_Homo sapiens_hsa051690.35448293
96Lysine degradation_Homo sapiens_hsa003100.33004896
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32966226
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.32537877
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32063855
100Tight junction_Homo sapiens_hsa045300.31623018

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