PPIAP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.37589040
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.44710059
3cytidine deamination (GO:0009972)5.15874455
4cytidine metabolic process (GO:0046087)5.15874455
5cytidine catabolic process (GO:0006216)5.15874455
6ATP synthesis coupled proton transport (GO:0015986)5.09590668
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.09590668
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.94609212
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49656974
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.31007725
11respiratory electron transport chain (GO:0022904)4.27315837
12pyrimidine ribonucleoside catabolic process (GO:0046133)4.24024132
13electron transport chain (GO:0022900)4.21417773
14regulation of cellular amino acid metabolic process (GO:0006521)4.20523280
15protein complex biogenesis (GO:0070271)4.11654724
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.09454930
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.09454930
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02098565
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00187045
20sequestering of actin monomers (GO:0042989)3.95385253
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.87253129
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.87253129
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.87153919
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.87153919
25signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.87153919
26chaperone-mediated protein transport (GO:0072321)3.85738944
27mitochondrial respiratory chain complex assembly (GO:0033108)3.82458916
28rRNA modification (GO:0000154)3.80984859
29proteasome assembly (GO:0043248)3.79510500
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74138152
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.74138152
32NADH dehydrogenase complex assembly (GO:0010257)3.74138152
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71499610
34signal transduction involved in cell cycle checkpoint (GO:0072395)3.69788035
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.69622064
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.69622064
37regulation of chronic inflammatory response (GO:0002676)3.67523252
38negative regulation of ligase activity (GO:0051352)3.66327598
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66327598
40protein neddylation (GO:0045116)3.66270492
41respiratory chain complex IV assembly (GO:0008535)3.55888432
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.54855594
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49776363
44regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45881230
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45309491
46regulation of mitochondrial translation (GO:0070129)3.43390510
47iron-sulfur cluster assembly (GO:0016226)3.40002683
48metallo-sulfur cluster assembly (GO:0031163)3.40002683
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.35416780
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.33040984
51deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.32277809
52preassembly of GPI anchor in ER membrane (GO:0016254)3.21120967
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.20990347
54termination of RNA polymerase III transcription (GO:0006386)3.20990347
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19411614
56hydrogen ion transmembrane transport (GO:1902600)3.17989555
57positive regulation of prostaglandin secretion (GO:0032308)3.17873449
58ubiquinone biosynthetic process (GO:0006744)3.14235903
59regulation of cellular amine metabolic process (GO:0033238)3.13403547
60protein targeting to mitochondrion (GO:0006626)3.11905025
61rRNA methylation (GO:0031167)3.09590286
62regulation of isotype switching to IgG isotypes (GO:0048302)3.07841886
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06293357
64cytochrome complex assembly (GO:0017004)3.04579885
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04381288
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04110699
67gonadal mesoderm development (GO:0007506)3.03900580
68actin nucleation (GO:0045010)3.00607017
69kynurenine metabolic process (GO:0070189)2.99535161
70GTP biosynthetic process (GO:0006183)2.98889333
71proton transport (GO:0015992)2.98101982
72positive regulation of cell cycle arrest (GO:0071158)2.97890118
73establishment of protein localization to mitochondrion (GO:0072655)2.97534068
74DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.97258901
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93057487
76hydrogen transport (GO:0006818)2.90408717
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89401470
78protein localization to mitochondrion (GO:0070585)2.87903496
79cullin deneddylation (GO:0010388)2.86989352
80ATP biosynthetic process (GO:0006754)2.86405302
812-deoxyribonucleotide biosynthetic process (GO:0009265)2.85701426
82deoxyribose phosphate biosynthetic process (GO:0046385)2.85701426
83ubiquinone metabolic process (GO:0006743)2.85441078
84positive regulation of ligase activity (GO:0051351)2.84984223
85L-methionine salvage (GO:0071267)2.82982269
86L-methionine biosynthetic process (GO:0071265)2.82982269
87amino acid salvage (GO:0043102)2.82982269
88platelet dense granule organization (GO:0060155)2.82017601
89T cell migration (GO:0072678)2.79614669
90mannosylation (GO:0097502)2.78873805
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77835179
92piRNA metabolic process (GO:0034587)2.73210144
93water-soluble vitamin biosynthetic process (GO:0042364)2.71348522
94antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.70293977
95protein deneddylation (GO:0000338)2.69959939
96GPI anchor biosynthetic process (GO:0006506)2.68231186
97GPI anchor metabolic process (GO:0006505)2.66518565
98regulation of T cell chemotaxis (GO:0010819)2.65572353
99positive regulation of T cell chemotaxis (GO:0010820)2.65572353
100regulation of T cell receptor signaling pathway (GO:0050856)2.64495229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.63826635
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60790064
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.86622309
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.74726893
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.69677118
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.55287419
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36141594
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13597818
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92776029
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89450443
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82204387
12VDR_23849224_ChIP-Seq_CD4+_Human2.81274484
13VDR_22108803_ChIP-Seq_LS180_Human2.60951958
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54317677
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.54202265
16ELK1_19687146_ChIP-ChIP_HELA_Human2.49612246
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45944404
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30585837
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18959597
20FOXP3_21729870_ChIP-Seq_TREG_Human2.18639984
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17204044
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.10129640
23ZNF274_21170338_ChIP-Seq_K562_Hela2.03561357
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95840206
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89411257
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.87816996
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.81672481
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76808648
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.72630097
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.70681491
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65624827
32PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.63034895
33IGF1R_20145208_ChIP-Seq_DFB_Human1.61773540
34MYC_18940864_ChIP-ChIP_HL60_Human1.60178610
35GATA3_26560356_Chip-Seq_TH2_Human1.53307128
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.50138133
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48323206
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47686447
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45751794
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42870538
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38625511
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34728365
43TP53_22573176_ChIP-Seq_HFKS_Human1.34562983
44DCP1A_22483619_ChIP-Seq_HELA_Human1.32176454
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30032893
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28501928
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28439366
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27123552
49AR_20517297_ChIP-Seq_VCAP_Human1.26979550
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26272462
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.25774429
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24017699
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23432175
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22967344
55MYB_26560356_Chip-Seq_TH2_Human1.22608029
56GABP_19822575_ChIP-Seq_HepG2_Human1.22459138
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.20673697
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19766647
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16495622
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16446029
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16316986
62EWS_26573619_Chip-Seq_HEK293_Human1.15470434
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14486665
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.14460604
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14460604
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14365207
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13878682
68ER_23166858_ChIP-Seq_MCF-7_Human1.12940353
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11679697
70HTT_18923047_ChIP-ChIP_STHdh_Human1.10966902
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09957413
72TTF2_22483619_ChIP-Seq_HELA_Human1.08605309
73TAF2_19829295_ChIP-Seq_ESCs_Human1.06916049
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05812106
75IRF1_19129219_ChIP-ChIP_H3396_Human1.05539314
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05307188
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.03407564
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02853683
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02219865
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99180877
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98954815
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98260187
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97407847
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94909348
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93027517
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92789383
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91548799
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.90988328
89NCOR_22424771_ChIP-Seq_293T_Human0.90681428
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89597307
91GATA3_26560356_Chip-Seq_TH1_Human0.89238461
92GATA3_27048872_Chip-Seq_THYMUS_Human0.87751397
93NANOG_19829295_ChIP-Seq_ESCs_Human0.86937497
94SOX2_19829295_ChIP-Seq_ESCs_Human0.86937497
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.86580127
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86464771
97NANOG_20526341_ChIP-Seq_ESCs_Human0.85633257
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84903355
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.84870675
100P300_19829295_ChIP-Seq_ESCs_Human0.84779061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.09148933
2MP0004147_increased_porphyrin_level3.24682618
3MP0009333_abnormal_splenocyte_physiolog3.03530999
4MP0002138_abnormal_hepatobiliary_system2.99395355
5MP0000372_irregular_coat_pigmentation2.39647120
6MP0006072_abnormal_retinal_apoptosis2.36324738
7MP0003806_abnormal_nucleotide_metabolis2.29954035
8MP0003786_premature_aging2.28397350
9MP0008875_abnormal_xenobiotic_pharmacok2.26811075
10MP0008872_abnormal_physiological_respon2.22669111
11MP0002166_altered_tumor_susceptibility2.18702332
12MP0009785_altered_susceptibility_to2.11048936
13MP0008995_early_reproductive_senescence1.99697946
14MP0002837_dystrophic_cardiac_calcinosis1.97249760
15MP0001873_stomach_inflammation1.93627766
16MP0002102_abnormal_ear_morphology1.89207680
17MP0002006_tumorigenesis1.81876961
18MP0005645_abnormal_hypothalamus_physiol1.81616872
19MP0008877_abnormal_DNA_methylation1.81390917
20MP0005084_abnormal_gallbladder_morpholo1.78755828
21MP0002148_abnormal_hypersensitivity_rea1.71700343
22MP0006082_CNS_inflammation1.69302119
23MP0003763_abnormal_thymus_physiology1.67092044
24MP0002736_abnormal_nociception_after1.60556686
25MP0001919_abnormal_reproductive_system1.59342213
26MP0006036_abnormal_mitochondrial_physio1.59070472
27MP0001968_abnormal_touch/_nociception1.56651128
28MP0001800_abnormal_humoral_immune1.54911078
29MP0005000_abnormal_immune_tolerance1.48695766
30MP0003866_abnormal_defecation1.47817890
31MP0008058_abnormal_DNA_repair1.47684235
32MP0003195_calcinosis1.45637191
33MP0004145_abnormal_muscle_electrophysio1.45050608
34MP0001986_abnormal_taste_sensitivity1.42967028
35MP0002876_abnormal_thyroid_physiology1.42119377
36MP0005389_reproductive_system_phenotype1.41392046
37MP0001542_abnormal_bone_strength1.37587068
38MP0005083_abnormal_biliary_tract1.35111230
39MP0004142_abnormal_muscle_tone1.33193024
40MP0002723_abnormal_immune_serum1.30774174
41MP0005646_abnormal_pituitary_gland1.28434870
42MP0010386_abnormal_urinary_bladder1.26962526
43MP0005636_abnormal_mineral_homeostasis1.26797337
44MP0006035_abnormal_mitochondrial_morpho1.26603826
45MP0005360_urolithiasis1.26233953
46MP0006276_abnormal_autonomic_nervous1.25351446
47MP0009697_abnormal_copulation1.24732699
48MP0002420_abnormal_adaptive_immunity1.24424826
49MP0002822_catalepsy1.23798540
50MP0001905_abnormal_dopamine_level1.22448078
51MP0003567_abnormal_fetal_cardiomyocyte1.21768245
52MP0001835_abnormal_antigen_presentation1.21433107
53MP0005085_abnormal_gallbladder_physiolo1.21398167
54MP0001819_abnormal_immune_cell1.20699227
55MP0001790_abnormal_immune_system1.20021317
56MP0005387_immune_system_phenotype1.20021317
57MP0001501_abnormal_sleep_pattern1.19395423
58MP0005410_abnormal_fertilization1.17469980
59MP0000685_abnormal_immune_system1.16061006
60MP0001764_abnormal_homeostasis1.15221435
61MP0005551_abnormal_eye_electrophysiolog1.14844418
62MP0005025_abnormal_response_to1.14495822
63MP0002933_joint_inflammation1.14423843
64MP0004885_abnormal_endolymph1.13841502
65MP0002452_abnormal_antigen_presenting1.13443083
66MP0002234_abnormal_pharynx_morphology1.13373814
67MP0003186_abnormal_redox_activity1.08788171
68MP0005253_abnormal_eye_physiology1.08041580
69MP0003787_abnormal_imprinting1.03560980
70MP0001845_abnormal_inflammatory_respons1.03266613
71MP0003137_abnormal_impulse_conducting1.02418523
72MP0002163_abnormal_gland_morphology1.01019516
73MP0003718_maternal_effect0.98661032
74MP0000689_abnormal_spleen_morphology0.98439932
75MP0002160_abnormal_reproductive_system0.97873828
76MP0009745_abnormal_behavioral_response0.95781209
77MP0005310_abnormal_salivary_gland0.95175510
78MP0004742_abnormal_vestibular_system0.94001765
79MP0001243_abnormal_dermal_layer0.91979342
80MP0008469_abnormal_protein_level0.91196289
81MP0004957_abnormal_blastocyst_morpholog0.91004638
82MP0000716_abnormal_immune_system0.89093964
83MP0003646_muscle_fatigue0.88767786
84MP0009764_decreased_sensitivity_to0.86621986
85MP0002272_abnormal_nervous_system0.86420556
86MP0002693_abnormal_pancreas_physiology0.85161670
87MP0005365_abnormal_bile_salt0.83842380
88MP0002277_abnormal_respiratory_mucosa0.80386520
89MP0002722_abnormal_immune_system0.80182817
90MP0005332_abnormal_amino_acid0.78789400
91MP0008873_increased_physiological_sensi0.78304777
92MP0002405_respiratory_system_inflammati0.76967972
93MP0009643_abnormal_urine_homeostasis0.76481138
94MP0002398_abnormal_bone_marrow0.74178206
95MP0001119_abnormal_female_reproductive0.73865924
96MP0003252_abnormal_bile_duct0.73802860
97MP0001929_abnormal_gametogenesis0.71312180
98MP0002429_abnormal_blood_cell0.70893829
99MP0001765_abnormal_ion_homeostasis0.70601660
100MP0005379_endocrine/exocrine_gland_phen0.69954292

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.82397686
2Mitochondrial inheritance (HP:0001427)4.52749374
3Abnormal mitochondria in muscle tissue (HP:0008316)4.36712255
4Acute encephalopathy (HP:0006846)4.20427510
5Increased CSF lactate (HP:0002490)4.10026358
6Progressive macrocephaly (HP:0004481)3.97054859
7IgG deficiency (HP:0004315)3.96874524
8Hepatocellular necrosis (HP:0001404)3.68125040
9Aplastic anemia (HP:0001915)3.66835063
10Abnormality of B cell number (HP:0010975)3.45493565
11Hepatic necrosis (HP:0002605)3.43372042
12Cerebral edema (HP:0002181)3.31019216
133-Methylglutaconic aciduria (HP:0003535)3.30999206
14Lipid accumulation in hepatocytes (HP:0006561)3.25163744
15Increased hepatocellular lipid droplets (HP:0006565)3.22534954
16Elevated erythrocyte sedimentation rate (HP:0003565)3.05792784
17Congenital, generalized hypertrichosis (HP:0004540)3.02954410
18Hypoproteinemia (HP:0003075)3.01544437
19Pancreatic cysts (HP:0001737)2.95269495
20Congenital stationary night blindness (HP:0007642)2.89526839
21Lactic acidosis (HP:0003128)2.82804372
22Increased serum lactate (HP:0002151)2.81008061
23Abnormality of T cell number (HP:0011839)2.77414628
24Molar tooth sign on MRI (HP:0002419)2.77250398
25Abnormality of midbrain morphology (HP:0002418)2.77250398
26Aplasia/hypoplasia of the uterus (HP:0008684)2.76302455
27Respiratory failure (HP:0002878)2.73630949
28Abnormality of the prostate (HP:0008775)2.69899098
29Increased intramyocellular lipid droplets (HP:0012240)2.67483865
30Renal Fanconi syndrome (HP:0001994)2.65153437
31Severe combined immunodeficiency (HP:0004430)2.63595888
32Optic disc pallor (HP:0000543)2.62588598
33B lymphocytopenia (HP:0010976)2.56470795
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54463020
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53973534
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53973534
37Stomach cancer (HP:0012126)2.50537210
38Increased IgM level (HP:0003496)2.50533858
39Lethargy (HP:0001254)2.47423992
40Autoimmune hemolytic anemia (HP:0001890)2.45215034
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43933959
42Pancreatic fibrosis (HP:0100732)2.34850999
43Hypoplasia of the uterus (HP:0000013)2.32861649
44T lymphocytopenia (HP:0005403)2.31527859
45Attenuation of retinal blood vessels (HP:0007843)2.31323661
46Limb dystonia (HP:0002451)2.31281970
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30659202
48Increased muscle lipid content (HP:0009058)2.30387928
49Chronic diarrhea (HP:0002028)2.29589533
50True hermaphroditism (HP:0010459)2.29366438
51Pendular nystagmus (HP:0012043)2.28875838
52Abnormality of T cells (HP:0002843)2.28449417
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26883245
54Pancytopenia (HP:0001876)2.25859973
55Exercise intolerance (HP:0003546)2.23775153
56Degeneration of anterior horn cells (HP:0002398)2.22835309
57Abnormality of the anterior horn cell (HP:0006802)2.22835309
58Abnormality of eosinophils (HP:0001879)2.18140058
59Prostate neoplasm (HP:0100787)2.13115693
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.12943266
61Dicarboxylic aciduria (HP:0003215)2.12943266
62Oral leukoplakia (HP:0002745)2.12492901
63Eosinophilia (HP:0001880)2.09074550
64Abnormal rod and cone electroretinograms (HP:0008323)2.08596610
65Increased corneal curvature (HP:0100692)2.07578885
66Keratoconus (HP:0000563)2.07578885
67Methylmalonic acidemia (HP:0002912)2.07487707
68Abnormality of T cell physiology (HP:0011840)2.05665338
69Large for gestational age (HP:0001520)2.05589460
70Methylmalonic aciduria (HP:0012120)2.05057722
71Thyroiditis (HP:0100646)2.03185987
72Decreased central vision (HP:0007663)2.00850399
73Leukodystrophy (HP:0002415)1.99715354
74Cerebral palsy (HP:0100021)1.97975684
75Combined immunodeficiency (HP:0005387)1.97303048
76Erythroderma (HP:0001019)1.96848290
77Type II lissencephaly (HP:0007260)1.96246694
78Colon cancer (HP:0003003)1.95626107
79Emotional lability (HP:0000712)1.94215877
80Abnormality of the renal cortex (HP:0011035)1.92834792
81Abnormality of male internal genitalia (HP:0000022)1.91534135
82Autoimmune thrombocytopenia (HP:0001973)1.88821645
83Testicular atrophy (HP:0000029)1.88248167
84Constricted visual fields (HP:0001133)1.85950135
85Glycosuria (HP:0003076)1.85151315
86Abnormality of urine glucose concentration (HP:0011016)1.85151315
87Atrophy/Degeneration involving motor neurons (HP:0007373)1.84470041
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84385864
89Hyperphosphaturia (HP:0003109)1.83571296
90Joint swelling (HP:0001386)1.80831468
91Abolished electroretinogram (ERG) (HP:0000550)1.80303918
92CNS demyelination (HP:0007305)1.79618706
93Male pseudohermaphroditism (HP:0000037)1.76840968
94Abnormality of the renal collecting system (HP:0004742)1.76572204
95Hypothermia (HP:0002045)1.76400694
96IgM deficiency (HP:0002850)1.75443605
97Renal cortical cysts (HP:0000803)1.72820205
98Abnormality of the pons (HP:0007361)1.72696206
99Granulocytopenia (HP:0001913)1.71954488
100Medial flaring of the eyebrow (HP:0010747)1.71514419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.29759891
2TLK13.17624097
3KDR3.13910275
4ZAK2.97417917
5NUAK12.91635952
6TESK22.71064608
7ADRBK22.56615316
8VRK12.52838668
9TXK2.25904253
10SRPK12.21799191
11TAOK32.21017244
12BUB12.14108192
13MST42.09385860
14BCKDK2.03763303
15MAP3K121.88411496
16GRK11.79722497
17BCR1.66596705
18EIF2AK11.63466485
19INSRR1.59643451
20EIF2AK31.58870636
21TIE11.58423808
22TNK21.57208360
23MAP4K21.56524937
24PINK11.54394238
25WNK41.53338313
26ITK1.41421636
27CSNK1G31.36459497
28NME11.29143964
29LIMK11.23110306
30TRIM281.18022384
31STK391.17077130
32TAF11.14454332
33PASK1.12786645
34OXSR11.11029547
35FRK1.10285181
36GRK61.08185722
37CSNK1G11.07987893
38TEC1.07340957
39CSNK1A1L1.05820120
40DAPK11.04992805
41MAPKAPK31.01903776
42TESK10.98738393
43MAP2K70.95906832
44PBK0.95576748
45MYLK0.93852431
46CSNK1G20.90382245
47RPS6KA40.89020588
48FES0.84588571
49PRKCQ0.84461959
50PLK30.81759328
51TSSK60.80952162
52CDK80.79224417
53NEK10.78677341
54PDK20.78593045
55STK160.78019351
56WNK30.73812472
57IKBKB0.73345771
58PLK20.72519542
59MAP3K40.72375435
60CAMKK20.72317926
61DYRK20.71602205
62SYK0.71243557
63MAP4K10.70668412
64PLK40.70260729
65PHKG20.69268951
66PHKG10.69268951
67GRK70.69015702
68NME20.67014405
69MAPK130.66255517
70RPS6KA50.64680057
71ERBB30.63335786
72EIF2AK20.58877685
73BMPR1B0.58434419
74DAPK20.56379694
75PIK3CA0.54142537
76AURKA0.51481477
77PIM20.51099146
78CDK190.49544239
79LYN0.48871502
80CSNK2A10.48224379
81LCK0.47375064
82PIM10.42602933
83SCYL20.40947663
84PRKACA0.40105900
85DAPK30.40018075
86PLK10.39455618
87CSNK1A10.39404811
88CCNB10.38902066
89AURKB0.38607718
90CSNK2A20.38369767
91MATK0.38223946
92PRKCG0.37432266
93MINK10.37304148
94CAMK2A0.34876410
95PRKCE0.33384559
96ADRBK10.33283056
97PRKCA0.33152424
98IGF1R0.32421756
99MAPKAPK50.31467538
100GRK50.30212191

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.14808307
2Oxidative phosphorylation_Homo sapiens_hsa001904.09690271
3Parkinsons disease_Homo sapiens_hsa050123.35023367
4Protein export_Homo sapiens_hsa030603.17309588
5Primary immunodeficiency_Homo sapiens_hsa053402.81790043
6RNA polymerase_Homo sapiens_hsa030202.50098856
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47936615
8Ribosome_Homo sapiens_hsa030102.42798477
9Alzheimers disease_Homo sapiens_hsa050102.33488727
10Huntingtons disease_Homo sapiens_hsa050162.17046400
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04741855
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85120600
13Autoimmune thyroid disease_Homo sapiens_hsa053201.81402241
14Allograft rejection_Homo sapiens_hsa053301.81219248
15Homologous recombination_Homo sapiens_hsa034401.72070217
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70660436
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.64972856
18Mismatch repair_Homo sapiens_hsa034301.51714087
19Asthma_Homo sapiens_hsa053101.48497562
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48262878
21RNA degradation_Homo sapiens_hsa030181.34213798
22Spliceosome_Homo sapiens_hsa030401.33602069
23Pyrimidine metabolism_Homo sapiens_hsa002401.32790167
24Graft-versus-host disease_Homo sapiens_hsa053321.30930557
25Antigen processing and presentation_Homo sapiens_hsa046121.29451998
26Cardiac muscle contraction_Homo sapiens_hsa042601.28641338
27Phototransduction_Homo sapiens_hsa047441.28526133
28Caffeine metabolism_Homo sapiens_hsa002321.27894586
29Propanoate metabolism_Homo sapiens_hsa006401.22597040
30Type I diabetes mellitus_Homo sapiens_hsa049401.21002244
31DNA replication_Homo sapiens_hsa030301.19252898
32Basal transcription factors_Homo sapiens_hsa030221.16955255
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16823007
34Sulfur metabolism_Homo sapiens_hsa009201.12195707
35Linoleic acid metabolism_Homo sapiens_hsa005911.12043649
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09457446
37Rheumatoid arthritis_Homo sapiens_hsa053231.09352031
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06907492
39Hematopoietic cell lineage_Homo sapiens_hsa046401.06345047
40Nitrogen metabolism_Homo sapiens_hsa009101.05742081
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03032320
42Nucleotide excision repair_Homo sapiens_hsa034201.02244981
43Base excision repair_Homo sapiens_hsa034100.96826139
44Purine metabolism_Homo sapiens_hsa002300.96702169
45RNA transport_Homo sapiens_hsa030130.94156235
46Fatty acid elongation_Homo sapiens_hsa000620.94093137
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.92905405
48Chemical carcinogenesis_Homo sapiens_hsa052040.90012344
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89530198
50One carbon pool by folate_Homo sapiens_hsa006700.88732637
51Pyruvate metabolism_Homo sapiens_hsa006200.87181006
52Glutathione metabolism_Homo sapiens_hsa004800.87069705
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86985034
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86670518
55Peroxisome_Homo sapiens_hsa041460.86381775
56T cell receptor signaling pathway_Homo sapiens_hsa046600.85781060
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85494700
58Folate biosynthesis_Homo sapiens_hsa007900.85372820
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85274369
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84092489
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82680265
62Tryptophan metabolism_Homo sapiens_hsa003800.82074449
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79266990
64Fanconi anemia pathway_Homo sapiens_hsa034600.78994802
65Sulfur relay system_Homo sapiens_hsa041220.76505941
66Collecting duct acid secretion_Homo sapiens_hsa049660.72556342
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70470532
68Metabolic pathways_Homo sapiens_hsa011000.69581880
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69387862
70Butanoate metabolism_Homo sapiens_hsa006500.67084174
71Arachidonic acid metabolism_Homo sapiens_hsa005900.66814914
72Systemic lupus erythematosus_Homo sapiens_hsa053220.66227740
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.65821411
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63819088
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61610126
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.60328345
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60212692
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57868763
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53320584
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.50807491
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49805716
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49540468
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.48156875
84Regulation of autophagy_Homo sapiens_hsa041400.47917282
85Fat digestion and absorption_Homo sapiens_hsa049750.46606638
86Ether lipid metabolism_Homo sapiens_hsa005650.46336979
87Fatty acid degradation_Homo sapiens_hsa000710.43611675
88Steroid biosynthesis_Homo sapiens_hsa001000.41882167
89Retinol metabolism_Homo sapiens_hsa008300.41277613
90Viral myocarditis_Homo sapiens_hsa054160.41011305
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40670201
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39775014
93Fatty acid metabolism_Homo sapiens_hsa012120.37497726
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37436417
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37393770
96Epstein-Barr virus infection_Homo sapiens_hsa051690.33407753
97Measles_Homo sapiens_hsa051620.30587308
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.29126379
99Non-homologous end-joining_Homo sapiens_hsa034500.28786152
100Shigellosis_Homo sapiens_hsa051310.26879713

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