ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	7.80362158
2	diol metabolic process (GO:0034311)	7.14506786
3	lipopolysaccharide biosynthetic process (GO:0009103)	6.36954537
4	sphingoid metabolic process (GO:0046519)	6.10639342
5	lipopolysaccharide metabolic process (GO:0008653)	5.48924036
6	ribosomal small subunit assembly (GO:0000028)	5.47452485
7	regulation of meiosis I (GO:0060631)	5.28655967
8	DNA methylation involved in gamete generation (GO:0043046)	5.14895883
9	negative regulation of telomere maintenance (GO:0032205)	4.72428725
10	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.64994239
11	viral transcription (GO:0019083)	4.58555630
12	translational termination (GO:0006415)	4.57554593
13	piRNA metabolic process (GO:0034587)	4.33889331
14	ribosomal small subunit biogenesis (GO:0042274)	4.30507187
15	sulfate transmembrane transport (GO:1902358)	4.13863470
16	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	4.04853270
17	behavioral response to nicotine (GO:0035095)	3.97815792
18	centriole replication (GO:0007099)	3.91590040
19	translational elongation (GO:0006414)	3.87411788
20	paraxial mesoderm development (GO:0048339)	3.73413852
21	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.73132133
22	protein-chromophore linkage (GO:0018298)	3.72846434
23	cotranslational protein targeting to membrane (GO:0006613)	3.70689137
24	protein targeting to ER (GO:0045047)	3.67088304
25	maturation of SSU-rRNA (GO:0030490)	3.64911756
26	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.62491119
27	spinal cord association neuron differentiation (GO:0021527)	3.59487590
28	reciprocal DNA recombination (GO:0035825)	3.59478941
29	reciprocal meiotic recombination (GO:0007131)	3.59478941
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.53602258
31	protein localization to endoplasmic reticulum (GO:0070972)	3.51168933
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50529387
33	heme transport (GO:0015886)	3.50188164
34	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.49613391
35	cellular protein complex disassembly (GO:0043624)	3.45907484
36	sulfate transport (GO:0008272)	3.42795295
37	regulation of mitochondrial translation (GO:0070129)	3.41025128
38	cell proliferation in forebrain (GO:0021846)	3.38946233
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.35607449
40	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.33568648
41	ATP synthesis coupled proton transport (GO:0015986)	3.33568648
42	viral life cycle (GO:0019058)	3.32849114
43	notochord development (GO:0030903)	3.32816979
44	meiotic chromosome segregation (GO:0045132)	3.32189049
45	DNA deamination (GO:0045006)	3.31489717
46	pseudouridine synthesis (GO:0001522)	3.25234487
47	regulation of chronic inflammatory response (GO:0002676)	3.24636639
48	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.22262256
49	spliceosomal complex assembly (GO:0000245)	3.16905192
50	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.12828344
51	ribosomal large subunit biogenesis (GO:0042273)	3.06656975
52	ribonucleoprotein complex disassembly (GO:0032988)	3.05749395
53	translational initiation (GO:0006413)	2.97795452
54	positive regulation of meiosis (GO:0045836)	2.97587539
55	macromolecular complex disassembly (GO:0032984)	2.97519976
56	protein complex disassembly (GO:0043241)	2.96891776
57	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.95467614
58	urate metabolic process (GO:0046415)	2.93700390
59	positive regulation of prostaglandin secretion (GO:0032308)	2.92028678
60	response to mercury ion (GO:0046689)	2.86541889
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.85977888
62	protein complex biogenesis (GO:0070271)	2.82943989
63	positive regulation of developmental pigmentation (GO:0048087)	2.82655822
64	cellular response to exogenous dsRNA (GO:0071360)	2.82249453
65	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.82041578
66	L-phenylalanine catabolic process (GO:0006559)	2.80051335
67	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.80051335
68	respiratory electron transport chain (GO:0022904)	2.79652343
69	rhodopsin mediated signaling pathway (GO:0016056)	2.79173774
70	serotonin receptor signaling pathway (GO:0007210)	2.78422743
71	electron transport chain (GO:0022900)	2.77861079
72	positive regulation of meiotic cell cycle (GO:0051446)	2.76634067
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.76023884
74	NADH dehydrogenase complex assembly (GO:0010257)	2.76023884
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.76023884
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.74446985
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.74446985
78	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74128730
79	chaperone-mediated protein transport (GO:0072321)	2.72037990
80	adaptation of signaling pathway (GO:0023058)	2.71815981
81	iron coordination entity transport (GO:1901678)	2.70471019
82	thalamus development (GO:0021794)	2.69500873
83	regulation of pigment cell differentiation (GO:0050932)	2.68903841
84	translation (GO:0006412)	2.65443634
85	parturition (GO:0007567)	2.64906026
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.64108300
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63028804
88	regulation of telomere maintenance (GO:0032204)	2.61798159
89	mannosylation (GO:0097502)	2.61714742
90	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61601643
91	auditory receptor cell differentiation (GO:0042491)	2.60888242
92	ribonucleoprotein complex biogenesis (GO:0022613)	2.60050608
93	glycerol metabolic process (GO:0006071)	2.57811368
94	termination of RNA polymerase III transcription (GO:0006386)	2.53519795
95	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.53519795
96	cellular component biogenesis (GO:0044085)	2.53030074
97	removal of superoxide radicals (GO:0019430)	2.52641760
98	cellular response to superoxide (GO:0071451)	2.52641760
99	cellular response to oxygen radical (GO:0071450)	2.52641760
100	centriole assembly (GO:0098534)	2.52456552

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.14828590
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.87821429
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.78537762
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.39441149
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.37978984
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01717906
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.79156460
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63603892
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.41623547
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.40355067
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39097040
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38416395
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95421840
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.95192713
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.91759634
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.87654501
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77214689
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.75823063
19	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.72953448
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71153347
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.67184471
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.66851561
23	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.62370148
24	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.58930712
25	VDR_22108803_ChIP-Seq_LS180_Human	1.58437202
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55900494
27	P300_19829295_ChIP-Seq_ESCs_Human	1.55724819
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.55232947
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52334097
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.48134531
31	STAT1_20625510_ChIP-Seq_HELA_Human	1.47183296
32	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.41341029
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40972594
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.40801377
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.39371586
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38541587
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38541587
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.37314992
39	HOXB7_26014856_ChIP-Seq_BT474_Human	1.35134637
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34289198
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.30657104
42	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28113727
43	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27544573
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27477152
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27399179
46	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.26750342
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.26507698
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25969220
49	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25806797
50	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.25076734
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24646376
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24646376
53	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24367567
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.23431899
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22949930
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.22319106
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.20667901
58	NCOR_22424771_ChIP-Seq_293T_Human	1.20137133
59	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19300694
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.17596179
61	FOXP3_21729870_ChIP-Seq_TREG_Human	1.16715825
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.16668404
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14487310
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.13308978
65	AR_20517297_ChIP-Seq_VCAP_Human	1.10202111
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08516551
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.08238471
68	OCT4_20526341_ChIP-Seq_ESCs_Human	1.06832157
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06480976
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06480976
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.05981873
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.05925523
73	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.05510686
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.04456100
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04186098
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.03691260
77	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.03419476
78	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02985960
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.02339910
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02291111
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02215059
82	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00466827
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.98504360
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97769275
85	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97250527
86	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97100602
87	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96160049
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95763488
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95438622
90	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.93266191
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92816833
92	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92741684
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.92655415
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92184422
95	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91350146
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91279160
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90298163
98	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88403360
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88244335
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87492067

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	6.41664635
2	MP0002653_abnormal_ependyma_morphology	6.25385028
3	MP0003136_yellow_coat_color	6.14898922
4	MP0005171_absent_coat_pigmentation	4.44424226
5	MP0003890_abnormal_embryonic-extraembry	3.39977628
6	MP0003787_abnormal_imprinting	3.06739387
7	MP0003646_muscle_fatigue	2.91397592
8	MP0004147_increased_porphyrin_level	2.70689364
9	MP0009379_abnormal_foot_pigmentation	2.33854103
10	MP0006292_abnormal_olfactory_placode	2.14551501
11	MP0003045_fibrosis	2.03958357
12	MP0003011_delayed_dark_adaptation	1.92700068
13	MP0005670_abnormal_white_adipose	1.86552800
14	MP0008877_abnormal_DNA_methylation	1.83988245
15	MP0003879_abnormal_hair_cell	1.83046288
16	MP0008875_abnormal_xenobiotic_pharmacok	1.78619104
17	MP0005085_abnormal_gallbladder_physiolo	1.78244870
18	MP0001485_abnormal_pinna_reflex	1.77346018
19	MP0002938_white_spotting	1.73921678
20	MP0002102_abnormal_ear_morphology	1.72210622
21	MP0005646_abnormal_pituitary_gland	1.70386428
22	MP0002138_abnormal_hepatobiliary_system	1.64448953
23	MP0008872_abnormal_physiological_respon	1.62466396
24	MP0004142_abnormal_muscle_tone	1.59450975
25	MP0001984_abnormal_olfaction	1.57997529
26	MP0004742_abnormal_vestibular_system	1.57885498
27	MP0008789_abnormal_olfactory_epithelium	1.57775084
28	MP0001986_abnormal_taste_sensitivity	1.49421729
29	MP0001501_abnormal_sleep_pattern	1.47619311
30	MP0002160_abnormal_reproductive_system	1.42808908
31	MP0001348_abnormal_lacrimal_gland	1.42761836
32	MP0000778_abnormal_nervous_system	1.35461971
33	MP0006072_abnormal_retinal_apoptosis	1.34779380
34	MP0004381_abnormal_hair_follicle	1.27791445
35	MP0005075_abnormal_melanosome_morpholog	1.23038973
36	MP0003123_paternal_imprinting	1.23003448
37	MP0002095_abnormal_skin_pigmentation	1.22614155
38	MP0002163_abnormal_gland_morphology	1.22605267
39	MP0005551_abnormal_eye_electrophysiolog	1.22461801
40	MP0002272_abnormal_nervous_system	1.19271129
41	MP0001486_abnormal_startle_reflex	1.16753079
42	MP0002277_abnormal_respiratory_mucosa	1.14976800
43	MP0001968_abnormal_touch/_nociception	1.13246623
44	MP0005365_abnormal_bile_salt	1.12791217
45	MP0005389_reproductive_system_phenotype	1.10019250
46	MP0000631_abnormal_neuroendocrine_gland	1.09070267
47	MP0003121_genomic_imprinting	1.07695089
48	MP0005499_abnormal_olfactory_system	1.06578430
49	MP0005394_taste/olfaction_phenotype	1.06578430
50	MP0005167_abnormal_blood-brain_barrier	1.01505793
51	MP0000026_abnormal_inner_ear	0.97712001
52	MP0002736_abnormal_nociception_after	0.96646464
53	MP0005645_abnormal_hypothalamus_physiol	0.95462841
54	MP0000049_abnormal_middle_ear	0.91524488
55	MP0003878_abnormal_ear_physiology	0.90395713
56	MP0005377_hearing/vestibular/ear_phenot	0.90395713
57	MP0003880_abnormal_central_pattern	0.89486502
58	MP0002557_abnormal_social/conspecific_i	0.89271889
59	MP0002735_abnormal_chemical_nociception	0.87992215
60	MP0003937_abnormal_limbs/digits/tail_de	0.87789352
61	MP0005253_abnormal_eye_physiology	0.87251237
62	MP0000427_abnormal_hair_cycle	0.87019807
63	MP0003938_abnormal_ear_development	0.86970037
64	MP0001502_abnormal_circadian_rhythm	0.85962742
65	MP0002572_abnormal_emotion/affect_behav	0.85922379
66	MP0009745_abnormal_behavioral_response	0.83789679
67	MP0009764_decreased_sensitivity_to	0.83083232
68	MP0002184_abnormal_innervation	0.82543389
69	MP0002751_abnormal_autonomic_nervous	0.80257601
70	MP0000749_muscle_degeneration	0.79628995
71	MP0003122_maternal_imprinting	0.79615830
72	MP0002752_abnormal_somatic_nervous	0.76278216
73	MP0005379_endocrine/exocrine_gland_phen	0.75194078
74	MP0001963_abnormal_hearing_physiology	0.74946237
75	MP0003195_calcinosis	0.72497472
76	MP0001293_anophthalmia	0.69449101
77	MP0001324_abnormal_eye_pigmentation	0.68341605
78	MP0001286_abnormal_eye_development	0.68064585
79	MP0002876_abnormal_thyroid_physiology	0.67755093
80	MP0003942_abnormal_urinary_system	0.67725693
81	MP0004130_abnormal_muscle_cell	0.67370167
82	MP0002075_abnormal_coat/hair_pigmentati	0.66744518
83	MP0002210_abnormal_sex_determination	0.66620440
84	MP0005195_abnormal_posterior_eye	0.64775006
85	MP0009046_muscle_twitch	0.62714911
86	MP0001905_abnormal_dopamine_level	0.62480209
87	MP0006276_abnormal_autonomic_nervous	0.61425985
88	MP0001440_abnormal_grooming_behavior	0.60566346
89	MP0003137_abnormal_impulse_conducting	0.60291593
90	MP0005084_abnormal_gallbladder_morpholo	0.59985539
91	MP0000230_abnormal_systemic_arterial	0.59968506
92	MP0002064_seizures	0.59410666
93	MP0003635_abnormal_synaptic_transmissio	0.59214305
94	MP0001529_abnormal_vocalization	0.59039523
95	MP0004885_abnormal_endolymph	0.57710861
96	MP0004484_altered_response_of	0.57203611
97	MP0001764_abnormal_homeostasis	0.56258530
98	MP0001186_pigmentation_phenotype	0.55529148
99	MP0000955_abnormal_spinal_cord	0.55448899
100	MP0002168_other_aberrant_phenotype	0.55405123

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.61925323
2	Colon cancer (HP:0003003)	5.44097123
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.99570461
4	Septo-optic dysplasia (HP:0100842)	4.57839194
5	Amelogenesis imperfecta (HP:0000705)	4.56165995
6	Pancreatic cysts (HP:0001737)	4.08999851
7	Aplastic anemia (HP:0001915)	3.96872377
8	Reticulocytopenia (HP:0001896)	3.88831043
9	Nephronophthisis (HP:0000090)	3.88553225
10	Parakeratosis (HP:0001036)	3.75277346
11	Neoplasm of the adrenal cortex (HP:0100641)	3.23248110
12	Abnormality of the renal cortex (HP:0011035)	3.21908893
13	Abnormality of the renal medulla (HP:0100957)	3.21617222
14	Abnormality of the labia minora (HP:0012880)	3.16950047
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.00623102
16	Tubular atrophy (HP:0000092)	3.00210247
17	Microvesicular hepatic steatosis (HP:0001414)	2.92777499
18	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.90717983
19	Increased hepatocellular lipid droplets (HP:0006565)	2.87487599
20	Optic nerve hypoplasia (HP:0000609)	2.85414863
21	Abnormal drinking behavior (HP:0030082)	2.84014426
22	Polydipsia (HP:0001959)	2.84014426
23	Lipid accumulation in hepatocytes (HP:0006561)	2.83456679
24	Stomach cancer (HP:0012126)	2.78111175
25	Pendular nystagmus (HP:0012043)	2.76842422
26	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.69818744
27	Rectal prolapse (HP:0002035)	2.67366664
28	Congenital ichthyosiform erythroderma (HP:0007431)	2.62375206
29	Pancreatic fibrosis (HP:0100732)	2.55334565
30	Abnormal number of erythroid precursors (HP:0012131)	2.47908205
31	Acanthocytosis (HP:0001927)	2.47061559
32	Molar tooth sign on MRI (HP:0002419)	2.38496299
33	Abnormality of midbrain morphology (HP:0002418)	2.38496299
34	Type II lissencephaly (HP:0007260)	2.38253765
35	Mitochondrial inheritance (HP:0001427)	2.38069394
36	Enlarged kidneys (HP:0000105)	2.30623940
37	Dialeptic seizures (HP:0011146)	2.29504979
38	Acute necrotizing encephalopathy (HP:0006965)	2.26322745
39	Bile duct proliferation (HP:0001408)	2.25572572
40	Abnormal biliary tract physiology (HP:0012439)	2.25572572
41	Acute encephalopathy (HP:0006846)	2.23837203
42	Opisthotonus (HP:0002179)	2.23171330
43	Focal seizures (HP:0007359)	2.22216050
44	Adrenal hypoplasia (HP:0000835)	2.18830922
45	Keratoconus (HP:0000563)	2.18727240
46	Increased corneal curvature (HP:0100692)	2.18727240
47	Erythroderma (HP:0001019)	2.17858585
48	Maternal diabetes (HP:0009800)	2.16142944
49	Absent septum pellucidum (HP:0001331)	2.15922290
50	Absent thumb (HP:0009777)	2.14295008
51	3-Methylglutaconic aciduria (HP:0003535)	2.14197942
52	Rib fusion (HP:0000902)	2.09514327
53	Synostosis of carpal bones (HP:0005048)	2.09320209
54	Synostosis involving the elbow (HP:0003938)	2.07763049
55	Humeroradial synostosis (HP:0003041)	2.07763049
56	Abnormality of urine glucose concentration (HP:0011016)	2.04879581
57	Glycosuria (HP:0003076)	2.04879581
58	True hermaphroditism (HP:0010459)	2.04811169
59	Polyphagia (HP:0002591)	2.04094751
60	Duplicated collecting system (HP:0000081)	2.03263030
61	Macrocytic anemia (HP:0001972)	1.99975425
62	Inability to walk (HP:0002540)	1.99855258
63	Abnormality of the renal collecting system (HP:0004742)	1.99181856
64	Growth hormone deficiency (HP:0000824)	1.98926382
65	Abnormality of DNA repair (HP:0003254)	1.98726604
66	Polyuria (HP:0000103)	1.97075231
67	Ulnar claw (HP:0001178)	1.95406274
68	IgM deficiency (HP:0002850)	1.94865866
69	Anencephaly (HP:0002323)	1.94350381
70	Increased CSF lactate (HP:0002490)	1.93115625
71	Anophthalmia (HP:0000528)	1.92809773
72	Vertebral fusion (HP:0002948)	1.91976987
73	Congenital stationary night blindness (HP:0007642)	1.90642247
74	Renal Fanconi syndrome (HP:0001994)	1.90526335
75	Medial flaring of the eyebrow (HP:0010747)	1.90411172
76	Renal cortical cysts (HP:0000803)	1.90301274
77	Stenosis of the external auditory canal (HP:0000402)	1.89431137
78	Congenital, generalized hypertrichosis (HP:0004540)	1.89273917
79	Cystic liver disease (HP:0006706)	1.88751824
80	Cerebellar dysplasia (HP:0007033)	1.87482296
81	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.85341395
82	Retinitis pigmentosa (HP:0000510)	1.82031455
83	Abnormality of the diencephalon (HP:0010662)	1.81531227
84	Neoplasm of the adrenal gland (HP:0100631)	1.81172260
85	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80779609
86	Hepatic necrosis (HP:0002605)	1.79554993
87	Chorioretinal atrophy (HP:0000533)	1.79384225
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.78662904
89	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.77955503
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76171041
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.73968192
92	Sclerocornea (HP:0000647)	1.71946163
93	Pancytopenia (HP:0001876)	1.71390417
94	Abnormality of the septum pellucidum (HP:0007375)	1.69797562
95	Hypoalbuminemia (HP:0003073)	1.69695991
96	Abnormal albumin level (HP:0012116)	1.69695991
97	Patellar aplasia (HP:0006443)	1.69440628
98	Chromsome breakage (HP:0040012)	1.68961498
99	Supernumerary bones of the axial skeleton (HP:0009144)	1.68912467
100	Hepatocellular necrosis (HP:0001404)	1.68602552

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.78710388
2	STK38L	5.71004750
3	ZAK	4.94226290
4	STK16	4.12131558
5	LATS2	4.00193418
6	BMPR1B	2.88868240
7	TLK1	2.48256654
8	PBK	2.36557128
9	WNK4	2.04394333
10	PRKD3	2.00060177
11	NLK	1.95124925
12	MAP2K2	1.91756702
13	TAOK3	1.81779869
14	VRK2	1.80337152
15	PINK1	1.77359682
16	CDK19	1.74954068
17	STK38	1.71023915
18	CSNK1A1L	1.64991486
19	STK3	1.58964647
20	STK39	1.53562797
21	ADRBK2	1.44690875
22	DYRK2	1.39856596
23	FRK	1.33934011
24	MELK	1.23020635
25	CSNK1G2	1.17551053
26	ACVR1B	1.15644949
27	MAP2K7	1.12489579
28	CSNK1G3	1.08519612
29	NUAK1	1.02989151
30	EIF2AK3	1.01439441
31	LIMK1	0.98967421
32	PIK3CG	0.95691242
33	GRK1	0.90315827
34	MAP4K2	0.88176931
35	BCKDK	0.87754575
36	NEK2	0.87285899
37	SRPK1	0.86809564
38	CSNK1G1	0.85767600
39	EIF2AK2	0.84918652
40	PLK4	0.80003815
41	MAP3K4	0.78808936
42	TNIK	0.75373756
43	TGFBR1	0.70855297
44	TTK	0.67307454
45	PRKCG	0.66196320
46	MOS	0.65252087
47	WNK1	0.62824695
48	GRK7	0.59913194
49	PIM1	0.59560960
50	EPHA4	0.58250135
51	VRK1	0.57664075
52	WNK3	0.57510061
53	PRKAA2	0.57048526
54	PAK3	0.56283973
55	ADRBK1	0.55156985
56	NME2	0.54043212
57	MET	0.50107632
58	MAP4K1	0.48286961
59	OXSR1	0.47766959
60	PLK1	0.47661286
61	TAF1	0.45225370
62	MAP3K11	0.41831496
63	KSR2	0.40718056
64	STK4	0.40616084
65	DAPK3	0.38727464
66	CSNK1A1	0.37360481
67	MAP3K9	0.37281689
68	GRK5	0.36881329
69	PRKCQ	0.36872334
70	CDC7	0.36084721
71	PLK3	0.35284033
72	LRRK2	0.35021409
73	DAPK2	0.31603164
74	CHEK2	0.30145801
75	PRKACA	0.24887809
76	CSNK1D	0.24561046
77	PRKCI	0.24539139
78	PLK2	0.24069221
79	CSNK2A2	0.23831404
80	NME1	0.23493499
81	MAPKAPK3	0.23166731
82	PDPK1	0.22734630
83	INSRR	0.21114930
84	CSNK1E	0.20427988
85	IRAK3	0.19426584
86	STK11	0.18769260
87	DYRK3	0.18423038
88	PHKG1	0.18308978
89	PHKG2	0.18308978
90	CSNK2A1	0.18225246
91	ITK	0.17255318
92	ARAF	0.17224933
93	PRKD1	0.15881121
94	TIE1	0.15401820
95	MARK1	0.15069472
96	CSF1R	0.14421849
97	PRKCE	0.14109560
98	PIK3CA	0.12574068
99	CAMK1	0.12109967
100	CAMK2A	0.11543612

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.60395652
2	Ribosome_Homo sapiens_hsa03010	4.15527362
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.21019908
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.99811331
5	Phototransduction_Homo sapiens_hsa04744	2.85679251
6	Sulfur relay system_Homo sapiens_hsa04122	2.54142697
7	Parkinsons disease_Homo sapiens_hsa05012	2.54094766
8	Homologous recombination_Homo sapiens_hsa03440	2.27047588
9	Folate biosynthesis_Homo sapiens_hsa00790	2.16133485
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.05009622
11	Proteasome_Homo sapiens_hsa03050	1.94977974
12	RNA polymerase_Homo sapiens_hsa03020	1.92791124
13	Nicotine addiction_Homo sapiens_hsa05033	1.91751269
14	Huntingtons disease_Homo sapiens_hsa05016	1.87364346
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77667536
16	One carbon pool by folate_Homo sapiens_hsa00670	1.77396220
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64163941
18	Alzheimers disease_Homo sapiens_hsa05010	1.63523542
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55284096
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.52955739
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.50324902
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48539519
23	Sphingolipid metabolism_Homo sapiens_hsa00600	1.45956737
24	Basal transcription factors_Homo sapiens_hsa03022	1.41680668
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.36972359
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.31282776
27	Asthma_Homo sapiens_hsa05310	1.30738651
28	Taste transduction_Homo sapiens_hsa04742	1.29344147
29	Mismatch repair_Homo sapiens_hsa03430	1.28150883
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.26806070
31	Butanoate metabolism_Homo sapiens_hsa00650	1.22491833
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21459330
33	Morphine addiction_Homo sapiens_hsa05032	1.21096067
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.19759537
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17334426
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14720367
37	Protein export_Homo sapiens_hsa03060	1.11388334
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07280509
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05874547
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05792824
41	Base excision repair_Homo sapiens_hsa03410	1.05445020
42	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.00990826
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99238445
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98995384
45	Propanoate metabolism_Homo sapiens_hsa00640	0.96618422
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95546222
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94410915
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91939140
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.89197122
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88659138
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.87761211
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.86268795
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84032242
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.79463399
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79177239
56	GABAergic synapse_Homo sapiens_hsa04727	0.78032218
57	Peroxisome_Homo sapiens_hsa04146	0.77799527
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77397335
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76856466
60	Fatty acid degradation_Homo sapiens_hsa00071	0.74959450
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68671039
62	RNA degradation_Homo sapiens_hsa03018	0.68432198
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.67952568
64	Metabolic pathways_Homo sapiens_hsa01100	0.67855658
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67279474
66	Spliceosome_Homo sapiens_hsa03040	0.67240792
67	Purine metabolism_Homo sapiens_hsa00230	0.64856442
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.62998331
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61808196
70	Serotonergic synapse_Homo sapiens_hsa04726	0.60694036
71	Pyruvate metabolism_Homo sapiens_hsa00620	0.60335589
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60327032
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59134819
74	Retinol metabolism_Homo sapiens_hsa00830	0.58406024
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57888560
76	RNA transport_Homo sapiens_hsa03013	0.57767066
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57248573
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56726213
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55452693
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53986455
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.53817961
82	Allograft rejection_Homo sapiens_hsa05330	0.53387278
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49332128
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.48726903
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47801688
86	DNA replication_Homo sapiens_hsa03030	0.47687746
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45027837
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.44913923
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44166099
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.42922779
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42694058
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.41554117
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40744183
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39117457
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.39049421
96	Olfactory transduction_Homo sapiens_hsa04740	0.36889176
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35752960
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33555560
99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.32981924
100	Circadian entrainment_Homo sapiens_hsa04713	0.30934275

PPIAP32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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