ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.07737460
2	ribosomal small subunit biogenesis (GO:0042274)	6.69092565
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.49304540
4	ATP synthesis coupled proton transport (GO:0015986)	6.49304540
5	viral transcription (GO:0019083)	6.14402662
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.13508027
7	translational termination (GO:0006415)	5.88575174
8	maturation of SSU-rRNA (GO:0030490)	5.48451406
9	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.46022236
10	ribosomal large subunit biogenesis (GO:0042273)	5.41743916
11	translational elongation (GO:0006414)	5.35110094
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.32696128
13	chaperone-mediated protein transport (GO:0072321)	5.30918421
14	cotranslational protein targeting to membrane (GO:0006613)	5.22189312
15	protein targeting to ER (GO:0045047)	5.19842483
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.08461799
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.08461799
18	NADH dehydrogenase complex assembly (GO:0010257)	5.08461799
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.99724537
20	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.98068017
21	protein localization to endoplasmic reticulum (GO:0070972)	4.87853467
22	protein complex biogenesis (GO:0070271)	4.84008052
23	pyrimidine nucleotide catabolic process (GO:0006244)	4.63929795
24	cellular protein complex disassembly (GO:0043624)	4.61341817
25	mitochondrial respiratory chain complex assembly (GO:0033108)	4.60653342
26	respiratory electron transport chain (GO:0022904)	4.54841137
27	GTP biosynthetic process (GO:0006183)	4.53205739
28	electron transport chain (GO:0022900)	4.51240266
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.47121562
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.45282011
31	viral life cycle (GO:0019058)	4.43014900
32	UTP biosynthetic process (GO:0006228)	4.20692939
33	translational initiation (GO:0006413)	4.19572631
34	regulation of mitochondrial translation (GO:0070129)	4.15712629
35	ribonucleoprotein complex biogenesis (GO:0022613)	4.09421637
36	cellular component biogenesis (GO:0044085)	4.07720930
37	base-excision repair, AP site formation (GO:0006285)	4.06761499
38	translation (GO:0006412)	4.06675255
39	cullin deneddylation (GO:0010388)	4.05951406
40	termination of RNA polymerase III transcription (GO:0006386)	4.05011909
41	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.05011909
42	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.98837801
43	protein complex disassembly (GO:0043241)	3.92631685
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.89687332
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.88229365
46	UTP metabolic process (GO:0046051)	3.81537374
47	respiratory chain complex IV assembly (GO:0008535)	3.80614552
48	ncRNA 3-end processing (GO:0043628)	3.74356127
49	deoxyribonucleotide catabolic process (GO:0009264)	3.70326806
50	ATP biosynthetic process (GO:0006754)	3.67710510
51	macromolecular complex disassembly (GO:0032984)	3.67683628
52	ubiquinone biosynthetic process (GO:0006744)	3.63186019
53	maturation of 5.8S rRNA (GO:0000460)	3.61366647
54	protein neddylation (GO:0045116)	3.54160027
55	protein deneddylation (GO:0000338)	3.54021084
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.52744659
57	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.52744659
58	rRNA processing (GO:0006364)	3.51741485
59	deoxyribose phosphate catabolic process (GO:0046386)	3.50470636
60	protein targeting to membrane (GO:0006612)	3.49223633
61	guanosine-containing compound biosynthetic process (GO:1901070)	3.48322607
62	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.47205548
63	rRNA metabolic process (GO:0016072)	3.45880194
64	pseudouridine synthesis (GO:0001522)	3.44501822
65	spliceosomal snRNP assembly (GO:0000387)	3.43215739
66	behavioral response to nicotine (GO:0035095)	3.40403145
67	cytochrome complex assembly (GO:0017004)	3.36258006
68	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.36034384
69	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.34851609
70	hydrogen ion transmembrane transport (GO:1902600)	3.34669284
71	ubiquinone metabolic process (GO:0006743)	3.34283380
72	proteasome assembly (GO:0043248)	3.33965602
73	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.30846213
74	protein targeting to mitochondrion (GO:0006626)	3.28218986
75	DNA replication checkpoint (GO:0000076)	3.27712513
76	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	3.23437687
77	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.20261500
78	CTP biosynthetic process (GO:0006241)	3.19998352
79	CTP metabolic process (GO:0046036)	3.19998352
80	nucleoside triphosphate biosynthetic process (GO:0009142)	3.13927090
81	proton transport (GO:0015992)	3.08575509
82	establishment of protein localization to mitochondrion (GO:0072655)	3.05340520
83	protein localization to mitochondrion (GO:0070585)	3.04325106
84	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.03917296
85	mRNA catabolic process (GO:0006402)	3.03658471
86	hydrogen transport (GO:0006818)	3.02648025
87	DNA deamination (GO:0045006)	3.01393645
88	peptidyl-histidine modification (GO:0018202)	3.00181056
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98584125
90	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.96576037
91	chromatin remodeling at centromere (GO:0031055)	2.96299266
92	water-soluble vitamin biosynthetic process (GO:0042364)	2.95740059
93	regulation of cellular respiration (GO:0043457)	2.95350326
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.94622863
95	quinone biosynthetic process (GO:1901663)	2.92915233
96	purine nucleobase biosynthetic process (GO:0009113)	2.91553911
97	RNA catabolic process (GO:0006401)	2.90377127
98	negative regulation of ligase activity (GO:0051352)	2.88980909
99	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.88980909
100	regulation of cellular amino acid metabolic process (GO:0006521)	2.86648970

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.72643344
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.43505410
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.33701238
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.90501468
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.79398124
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.57900581
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.44343082
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.40147081
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.15178963
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.99920232
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.92874817
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.77228916
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.76496510
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69446687
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.68940972
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.64795747
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.60083554
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.55719493
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.52474746
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.29469641
21	XRN2_22483619_ChIP-Seq_HELA_Human	2.23894573
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.23614002
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23596585
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.13944325
25	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07017586
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.05404343
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.03541602
28	TTF2_22483619_ChIP-Seq_HELA_Human	2.01630222
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.99801779
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99458755
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.99113020
32	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.90034791
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.88945076
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.81128496
35	E2F7_22180533_ChIP-Seq_HELA_Human	1.79182073
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.76126515
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.75258899
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.74723879
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70874032
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.66836129
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.54689356
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.52284554
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49915641
44	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.46377535
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.43564476
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35144856
47	CIITA_25753668_ChIP-Seq_RAJI_Human	1.32737256
48	EZH2_22144423_ChIP-Seq_EOC_Human	1.29875150
49	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.28967937
50	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.26795300
51	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.25478802
52	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.25455763
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25035337
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22450170
55	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21184698
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20944966
57	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19471949
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.15189809
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13660340
60	VDR_22108803_ChIP-Seq_LS180_Human	1.12626449
61	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.10757905
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.10703616
63	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.08398868
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06937388
65	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.06823181
66	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05641700
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04720657
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04661903
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.04472523
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04176629
71	EWS_26573619_Chip-Seq_HEK293_Human	1.02445884
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.00790757
73	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00286693
74	FUS_26573619_Chip-Seq_HEK293_Human	0.99526733
75	NCOR_22424771_ChIP-Seq_293T_Human	0.98126315
76	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.97444939
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96713717
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.94638726
79	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.93841571
80	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.93438635
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92486940
82	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89718437
83	KDM5A_27292631_Chip-Seq_BREAST_Human	0.89147017
84	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.87560693
85	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.87428925
86	ERA_21632823_ChIP-Seq_H3396_Human	0.87213983
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.86950406
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86671705
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.84369704
90	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83984053
91	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83296236
92	AR_20517297_ChIP-Seq_VCAP_Human	0.81748036
93	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.81098170
94	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.80721631
95	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.80498587
96	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.79878751
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.79751211
98	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.78119273
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.75741930
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.75668831

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.64493103
2	MP0002138_abnormal_hepatobiliary_system	3.78619447
3	MP0006292_abnormal_olfactory_placode	3.35807883
4	MP0008875_abnormal_xenobiotic_pharmacok	2.75823112
5	MP0003186_abnormal_redox_activity	2.70460232
6	MP0005084_abnormal_gallbladder_morpholo	2.63259919
7	MP0002638_abnormal_pupillary_reflex	2.59256535
8	MP0003806_abnormal_nucleotide_metabolis	2.31615078
9	MP0000372_irregular_coat_pigmentation	2.14738514
10	MP0006072_abnormal_retinal_apoptosis	2.13173851
11	MP0002102_abnormal_ear_morphology	2.12692479
12	MP0008058_abnormal_DNA_repair	2.01770304
13	MP0003786_premature_aging	1.99687996
14	MP0003646_muscle_fatigue	1.91332826
15	MP0006036_abnormal_mitochondrial_physio	1.88134339
16	MP0010094_abnormal_chromosome_stability	1.87169090
17	MP0003693_abnormal_embryo_hatching	1.78776635
18	MP0004957_abnormal_blastocyst_morpholog	1.76552844
19	MP0004145_abnormal_muscle_electrophysio	1.76210967
20	MP0005075_abnormal_melanosome_morpholog	1.73676562
21	MP0001968_abnormal_touch/_nociception	1.71028998
22	MP0002837_dystrophic_cardiac_calcinosis	1.65266005
23	MP0001905_abnormal_dopamine_level	1.65169825
24	MP0003718_maternal_effect	1.64134734
25	MP0005389_reproductive_system_phenotype	1.61439503
26	MP0006054_spinal_hemorrhage	1.57582595
27	MP0005645_abnormal_hypothalamus_physiol	1.57485724
28	MP0001873_stomach_inflammation	1.57180488
29	MP0005360_urolithiasis	1.53057820
30	MP0008789_abnormal_olfactory_epithelium	1.47033430
31	MP0001919_abnormal_reproductive_system	1.46528001
32	MP0002160_abnormal_reproductive_system	1.42856827
33	MP0008872_abnormal_physiological_respon	1.42033033
34	MP0002938_white_spotting	1.36887760
35	MP0005499_abnormal_olfactory_system	1.36883667
36	MP0005394_taste/olfaction_phenotype	1.36883667
37	MP0005551_abnormal_eye_electrophysiolog	1.34975084
38	MP0003880_abnormal_central_pattern	1.34824281
39	MP0002095_abnormal_skin_pigmentation	1.32159797
40	MP0004142_abnormal_muscle_tone	1.29268202
41	MP0008877_abnormal_DNA_methylation	1.28175246
42	MP0002735_abnormal_chemical_nociception	1.24123641
43	MP0008932_abnormal_embryonic_tissue	1.21779974
44	MP0003111_abnormal_nucleus_morphology	1.21772087
45	MP0009764_decreased_sensitivity_to	1.21291916
46	MP0005085_abnormal_gallbladder_physiolo	1.20477990
47	MP0001293_anophthalmia	1.18297763
48	MP0002736_abnormal_nociception_after	1.18166287
49	MP0005377_hearing/vestibular/ear_phenot	1.17318181
50	MP0003878_abnormal_ear_physiology	1.17318181
51	MP0002277_abnormal_respiratory_mucosa	1.16972356
52	MP0008995_early_reproductive_senescence	1.12948396
53	MP0001348_abnormal_lacrimal_gland	1.11550151
54	MP0005408_hypopigmentation	1.10659274
55	MP0003567_abnormal_fetal_cardiomyocyte	1.10172875
56	MP0003315_abnormal_perineum_morphology	1.09229756
57	MP0008007_abnormal_cellular_replicative	1.08896217
58	MP0009745_abnormal_behavioral_response	1.08446538
59	MP0002733_abnormal_thermal_nociception	1.07792789
60	MP0005083_abnormal_biliary_tract	1.07433210
61	MP0002163_abnormal_gland_morphology	1.05965246
62	MP0005332_abnormal_amino_acid	1.05960194
63	MP0000049_abnormal_middle_ear	1.04789157
64	MP0005671_abnormal_response_to	1.03666905
65	MP0005253_abnormal_eye_physiology	1.03127953
66	MP0001764_abnormal_homeostasis	1.03007683
67	MP0001970_abnormal_pain_threshold	1.02087911
68	MP0006276_abnormal_autonomic_nervous	1.01904452
69	MP0001529_abnormal_vocalization	1.00952958
70	MP0009046_muscle_twitch	0.98625230
71	MP0008775_abnormal_heart_ventricle	0.96355507
72	MP0005195_abnormal_posterior_eye	0.93951723
73	MP0003077_abnormal_cell_cycle	0.91966870
74	MP0003011_delayed_dark_adaptation	0.89716801
75	MP0003123_paternal_imprinting	0.88758810
76	MP0002132_abnormal_respiratory_system	0.88741705
77	MP0005670_abnormal_white_adipose	0.88702676
78	MP0001986_abnormal_taste_sensitivity	0.88690502
79	MP0005187_abnormal_penis_morphology	0.87376755
80	MP0000647_abnormal_sebaceous_gland	0.84319479
81	MP0002272_abnormal_nervous_system	0.83781439
82	MP0004043_abnormal_pH_regulation	0.83205445
83	MP0001485_abnormal_pinna_reflex	0.81599007
84	MP0009333_abnormal_splenocyte_physiolog	0.80977712
85	MP0003121_genomic_imprinting	0.79930698
86	MP0005410_abnormal_fertilization	0.79563324
87	MP0002653_abnormal_ependyma_morphology	0.78508819
88	MP0005646_abnormal_pituitary_gland	0.77720639
89	MP0001984_abnormal_olfaction	0.73507234
90	MP0005319_abnormal_enzyme/_coenzyme	0.73490505
91	MP0002822_catalepsy	0.73040930
92	MP0005391_vision/eye_phenotype	0.71569187
93	MP0005636_abnormal_mineral_homeostasis	0.70625687
94	MP0001663_abnormal_digestive_system	0.69425060
95	MP0000613_abnormal_salivary_gland	0.69028609
96	MP0002210_abnormal_sex_determination	0.66470422
97	MP0000653_abnormal_sex_gland	0.66454884
98	MP0001502_abnormal_circadian_rhythm	0.64162586
99	MP0002734_abnormal_mechanical_nocicepti	0.63064351
100	MP0003252_abnormal_bile_duct	0.62453902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.19012728
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.60656531
3	Acute encephalopathy (HP:0006846)	5.23857348
4	Mitochondrial inheritance (HP:0001427)	5.13334610
5	Progressive macrocephaly (HP:0004481)	5.05485357
6	Increased CSF lactate (HP:0002490)	4.66328679
7	Increased hepatocellular lipid droplets (HP:0006565)	4.60197012
8	Lipid accumulation in hepatocytes (HP:0006561)	4.23543311
9	Cerebral edema (HP:0002181)	4.10529513
10	Hepatocellular necrosis (HP:0001404)	4.07149918
11	Reticulocytopenia (HP:0001896)	3.76091559
12	Renal Fanconi syndrome (HP:0001994)	3.75527760
13	Hepatic necrosis (HP:0002605)	3.70787194
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.66274592
15	Increased intramyocellular lipid droplets (HP:0012240)	3.60812618
16	Macrocytic anemia (HP:0001972)	3.49964264
17	Exertional dyspnea (HP:0002875)	3.40211361
18	Increased serum lactate (HP:0002151)	3.38404551
19	3-Methylglutaconic aciduria (HP:0003535)	3.32314590
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.32253967
21	Lactic acidosis (HP:0003128)	3.29491168
22	Abnormal number of erythroid precursors (HP:0012131)	3.18568972
23	Pendular nystagmus (HP:0012043)	3.09707433
24	Leukodystrophy (HP:0002415)	3.07513534
25	Abnormality of alanine metabolism (HP:0010916)	3.07269343
26	Hyperalaninemia (HP:0003348)	3.07269343
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.07269343
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.05677880
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.05677880
30	Increased muscle lipid content (HP:0009058)	3.02063278
31	Abnormality of the anterior horn cell (HP:0006802)	2.91981991
32	Degeneration of anterior horn cells (HP:0002398)	2.91981991
33	Exercise intolerance (HP:0003546)	2.90777296
34	Respiratory failure (HP:0002878)	2.90234786
35	Respiratory difficulties (HP:0002880)	2.86391225
36	Pancreatic fibrosis (HP:0100732)	2.75959945
37	Optic disc pallor (HP:0000543)	2.75164218
38	Parakeratosis (HP:0001036)	2.70231595
39	Abolished electroretinogram (ERG) (HP:0000550)	2.67024987
40	Microretrognathia (HP:0000308)	2.65185395
41	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.63019861
42	Abnormality of midbrain morphology (HP:0002418)	2.57577739
43	Molar tooth sign on MRI (HP:0002419)	2.57577739
44	Lethargy (HP:0001254)	2.46621301
45	Congenital, generalized hypertrichosis (HP:0004540)	2.42682768
46	Increased serum pyruvate (HP:0003542)	2.39862027
47	Pallor (HP:0000980)	2.37227633
48	Glycosuria (HP:0003076)	2.29753366
49	Abnormality of urine glucose concentration (HP:0011016)	2.29753366
50	Abnormality of renal resorption (HP:0011038)	2.29379253
51	Chorioretinal atrophy (HP:0000533)	2.28429795
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.27014897
53	Testicular atrophy (HP:0000029)	2.25158292
54	True hermaphroditism (HP:0010459)	2.22967081
55	Pancreatic cysts (HP:0001737)	2.19734656
56	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.17890351
57	Congenital stationary night blindness (HP:0007642)	2.14107822
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.10321775
59	Opisthotonus (HP:0002179)	2.08892115
60	Aplastic anemia (HP:0001915)	2.08349976
61	Sclerocornea (HP:0000647)	2.08208441
62	Septo-optic dysplasia (HP:0100842)	2.07477260
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.04726681
64	Abnormal respiratory motile cilium morphology (HP:0005938)	2.04726681
65	X-linked dominant inheritance (HP:0001423)	2.00356745
66	Hyperphosphaturia (HP:0003109)	1.97940633
67	Colon cancer (HP:0003003)	1.95472885
68	Progressive muscle weakness (HP:0003323)	1.94036003
69	Blindness (HP:0000618)	1.90094698
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87396557
71	CNS demyelination (HP:0007305)	1.85446579
72	B lymphocytopenia (HP:0010976)	1.84075937
73	Hyperglycinemia (HP:0002154)	1.81764263
74	Myokymia (HP:0002411)	1.81419781
75	Abnormality of the prostate (HP:0008775)	1.81024412
76	Stenosis of the external auditory canal (HP:0000402)	1.79597787
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78179540
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.78179540
79	Abnormal protein glycosylation (HP:0012346)	1.78179540
80	Abnormal glycosylation (HP:0012345)	1.78179540
81	Supernumerary spleens (HP:0009799)	1.77493963
82	Medial flaring of the eyebrow (HP:0010747)	1.77340378
83	Cleft eyelid (HP:0000625)	1.74995436
84	Generalized aminoaciduria (HP:0002909)	1.73629375
85	Abnormality of glycolysis (HP:0004366)	1.72689919
86	Gout (HP:0001997)	1.72529111
87	Sparse eyelashes (HP:0000653)	1.70250997
88	Congenital ichthyosiform erythroderma (HP:0007431)	1.70197956
89	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.68939848
90	Nephronophthisis (HP:0000090)	1.68149100
91	Absent thumb (HP:0009777)	1.68141401
92	Erythroderma (HP:0001019)	1.67330025
93	Depressed nasal ridge (HP:0000457)	1.67048256
94	Absent/shortened dynein arms (HP:0200106)	1.64836452
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.64836452
96	Bile duct proliferation (HP:0001408)	1.64012113
97	Abnormal biliary tract physiology (HP:0012439)	1.64012113
98	Type I transferrin isoform profile (HP:0003642)	1.63741540
99	Abnormality of serum amino acid levels (HP:0003112)	1.63738260
100	Anencephaly (HP:0002323)	1.62669370

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.06623010
2	CDK19	3.98242900
3	TLK1	3.73217593
4	BUB1	3.65010505
5	NME2	3.45050151
6	BCKDK	3.44898238
7	NME1	2.86911625
8	WNK4	2.71848645
9	TIE1	2.48909338
10	OXSR1	2.26332234
11	GRK1	2.10148518
12	NUAK1	2.07574929
13	PBK	1.99724504
14	PDK2	1.99440395
15	STK39	1.99324978
16	STK16	1.95696369
17	CDC7	1.92634329
18	SRPK1	1.63431586
19	ADRBK2	1.58677723
20	DYRK2	1.58540924
21	VRK2	1.53086477
22	PLK4	1.47937301
23	NEK1	1.39902634
24	VRK1	1.36451458
25	CAMKK2	1.23470553
26	MAP4K2	1.16665258
27	LIMK1	1.11951210
28	PLK1	1.06756868
29	LRRK2	1.05272604
30	PLK2	1.04866232
31	PLK3	1.03316926
32	CSNK1G3	0.97236847
33	WNK1	0.95827483
34	AURKB	0.91485657
35	PINK1	0.89932516
36	CSNK1G1	0.88002711
37	ATR	0.81742174
38	RPS6KA5	0.80455539
39	ABL2	0.79944489
40	KIT	0.79161743
41	PRKCG	0.78301881
42	MAP3K12	0.78202670
43	INSRR	0.77341928
44	CSNK1G2	0.75356501
45	MKNK1	0.74930727
46	CSNK2A2	0.74157055
47	AURKA	0.72256173
48	EIF2AK3	0.69269041
49	CDK14	0.63804526
50	CSNK2A1	0.63076552
51	CSNK1A1L	0.62813450
52	PAK3	0.59141787
53	MAPKAPK5	0.58122068
54	STK4	0.56805339
55	PIK3CA	0.54551037
56	CDK11A	0.54255387
57	MINK1	0.51782788
58	CHEK2	0.51612069
59	TSSK6	0.51557501
60	ERBB2	0.50950680
61	IKBKB	0.50344178
62	BRSK1	0.49952015
63	BMPR2	0.49814842
64	WEE1	0.48057772
65	CCNB1	0.46628477
66	DAPK3	0.46550419
67	CDK15	0.45759623
68	CAMK1	0.45691698
69	CAMK1D	0.44242583
70	MAP2K2	0.44078606
71	PHKG2	0.43848914
72	PHKG1	0.43848914
73	DAPK1	0.43197511
74	ADRBK1	0.42899136
75	CDK18	0.42059450
76	MAP2K7	0.41959024
77	CSNK1E	0.41473258
78	ERBB3	0.41422055
79	TAOK3	0.40751874
80	PRKACA	0.40632267
81	CHEK1	0.40149502
82	RPS6KB2	0.39915952
83	PRKCI	0.39527657
84	TEC	0.38851294
85	TXK	0.38479183
86	CDK7	0.37511406
87	BMPR1B	0.37417788
88	PAK1	0.36823634
89	EPHA4	0.35525659
90	CAMK2D	0.35496186
91	KDR	0.34298726
92	WNK3	0.33268561
93	TTK	0.33050844
94	CSNK1A1	0.32966008
95	FLT3	0.32055895
96	BRSK2	0.31893719
97	MST4	0.31872174
98	MKNK2	0.31581885
99	PRKCA	0.30380720
100	ITK	0.28985941

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.86309431
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87161189
3	Parkinsons disease_Homo sapiens_hsa05012	3.29865188
4	Asthma_Homo sapiens_hsa05310	3.26412149
5	Proteasome_Homo sapiens_hsa03050	3.14995200
6	RNA polymerase_Homo sapiens_hsa03020	2.70396857
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.54771840
8	DNA replication_Homo sapiens_hsa03030	2.31703138
9	Huntingtons disease_Homo sapiens_hsa05016	2.27875442
10	Alzheimers disease_Homo sapiens_hsa05010	2.10974632
11	Allograft rejection_Homo sapiens_hsa05330	2.10677594
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.08575648
13	Homologous recombination_Homo sapiens_hsa03440	2.01778928
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.93792736
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.90801302
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86554558
17	Base excision repair_Homo sapiens_hsa03410	1.83198489
18	Protein export_Homo sapiens_hsa03060	1.79476919
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.77328255
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.75643057
21	Pyrimidine metabolism_Homo sapiens_hsa00240	1.75471682
22	One carbon pool by folate_Homo sapiens_hsa00670	1.73023891
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.70963958
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66465140
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.60992712
26	Mismatch repair_Homo sapiens_hsa03430	1.57422471
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55468570
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.46805075
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38020187
30	Sulfur relay system_Homo sapiens_hsa04122	1.33769457
31	Spliceosome_Homo sapiens_hsa03040	1.33749670
32	Purine metabolism_Homo sapiens_hsa00230	1.28439782
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28298959
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28163122
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.27425092
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26237112
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.20266121
38	RNA degradation_Homo sapiens_hsa03018	1.19898619
39	RNA transport_Homo sapiens_hsa03013	1.19713301
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18243786
41	Propanoate metabolism_Homo sapiens_hsa00640	1.11691746
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11327882
43	Peroxisome_Homo sapiens_hsa04146	0.96723598
44	Folate biosynthesis_Homo sapiens_hsa00790	0.96706710
45	Fatty acid elongation_Homo sapiens_hsa00062	0.89905671
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.88152232
47	Viral myocarditis_Homo sapiens_hsa05416	0.87946030
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81441779
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80392815
50	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.78470571
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77397655
52	Phototransduction_Homo sapiens_hsa04744	0.76951140
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.76362290
54	Butanoate metabolism_Homo sapiens_hsa00650	0.74588617
55	Metabolic pathways_Homo sapiens_hsa01100	0.74069615
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72148269
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72015424
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.70373007
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.69848698
60	Basal transcription factors_Homo sapiens_hsa03022	0.65429512
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.65062682
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.64759345
63	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.64350303
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62959357
65	Alcoholism_Homo sapiens_hsa05034	0.61365084
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.59932835
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59221128
68	Carbon metabolism_Homo sapiens_hsa01200	0.58382256
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.56124713
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55635159
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.55290254
72	Non-homologous end-joining_Homo sapiens_hsa03450	0.51549672
73	Fatty acid degradation_Homo sapiens_hsa00071	0.49590991
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.48876258
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.48768608
76	Glutathione metabolism_Homo sapiens_hsa00480	0.44969599
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43207390
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.42567617
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38607693
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38525886
81	Leishmaniasis_Homo sapiens_hsa05140	0.38148590
82	Nicotine addiction_Homo sapiens_hsa05033	0.36903506
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.34572831
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33587236
85	Renin-angiotensin system_Homo sapiens_hsa04614	0.31726719
86	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.31282609
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.29668026
88	Regulation of autophagy_Homo sapiens_hsa04140	0.29328857
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28029546
90	Olfactory transduction_Homo sapiens_hsa04740	0.27350307
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27313417
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26206373
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25384191
94	Cell cycle_Homo sapiens_hsa04110	0.25357792
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.23952308
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23407914
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23193594
98	Sulfur metabolism_Homo sapiens_hsa00920	0.21411256
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.20088674
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20031234

PPIAP33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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