PPIAP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.32026938
2cytidine metabolic process (GO:0046087)6.91655682
3cytidine catabolic process (GO:0006216)6.91655682
4cytidine deamination (GO:0009972)6.91655682
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.83907790
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.93261320
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27638010
8sequestering of actin monomers (GO:0042989)5.18349053
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.07716944
10ATP synthesis coupled proton transport (GO:0015986)4.93432063
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93432063
12protein neddylation (GO:0045116)4.86663860
13respiratory electron transport chain (GO:0022904)4.31958157
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.25788617
15electron transport chain (GO:0022900)4.23504033
16Arp2/3 complex-mediated actin nucleation (GO:0034314)4.14690340
17proteasome assembly (GO:0043248)4.09377186
18ribosomal small subunit assembly (GO:0000028)4.06273393
19purine deoxyribonucleotide catabolic process (GO:0009155)4.02942594
20protein complex biogenesis (GO:0070271)3.97793382
21regulation of cellular amino acid metabolic process (GO:0006521)3.97311099
22negative regulation of mast cell activation (GO:0033004)3.83006482
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81375582
24actin nucleation (GO:0045010)3.79555465
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78104561
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69333225
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69333225
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69333225
29platelet dense granule organization (GO:0060155)3.68802326
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67732415
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67732415
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65946889
33intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65946889
34regulation of chronic inflammatory response (GO:0002676)3.62545877
35positive T cell selection (GO:0043368)3.58414002
36negative regulation of T cell apoptotic process (GO:0070233)3.55867944
37mitochondrial respiratory chain complex assembly (GO:0033108)3.55201534
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.53163629
39signal transduction involved in DNA damage checkpoint (GO:0072422)3.48318131
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.48318131
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46056843
42cytolysis (GO:0019835)3.45233230
43iron-sulfur cluster assembly (GO:0016226)3.44720463
44metallo-sulfur cluster assembly (GO:0031163)3.44720463
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.44002801
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.40894769
47NADH dehydrogenase complex assembly (GO:0010257)3.40894769
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40894769
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40440906
50negative regulation of ligase activity (GO:0051352)3.40440906
51base-excision repair, AP site formation (GO:0006285)3.39855226
52positive thymic T cell selection (GO:0045059)3.36817085
53deoxyribonucleotide catabolic process (GO:0009264)3.35300114
54cytochrome complex assembly (GO:0017004)3.28334588
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28090210
56antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.26434569
57deoxyribose phosphate catabolic process (GO:0046386)3.17241077
58respiratory chain complex IV assembly (GO:0008535)3.16691260
59chaperone-mediated protein transport (GO:0072321)3.16500121
60pyrimidine nucleoside catabolic process (GO:0046135)3.13973272
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02712293
62negative T cell selection (GO:0043383)3.01644031
63negative regulation by host of viral transcription (GO:0043922)3.00611702
64positive regulation of prostaglandin secretion (GO:0032308)2.98085929
65hydrogen ion transmembrane transport (GO:1902600)2.97374066
66positive regulation of cell cycle arrest (GO:0071158)2.95436065
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95028258
68nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92820810
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92454295
70negative regulation of viral genome replication (GO:0045071)2.91875778
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.90409294
72regulation of cellular amine metabolic process (GO:0033238)2.86108470
73DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85640466
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85248632
75regulation of activation of Janus kinase activity (GO:0010533)2.84795385
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.83369504
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83006552
78positive regulation of ligase activity (GO:0051351)2.79168967
79ubiquinone biosynthetic process (GO:0006744)2.74406011
80proton transport (GO:0015992)2.74150129
81positive regulation of interleukin-8 secretion (GO:2000484)2.73656710
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71394640
83negative regulation of lymphocyte apoptotic process (GO:0070229)2.69817546
84purine deoxyribonucleotide metabolic process (GO:0009151)2.69550682
85hydrogen transport (GO:0006818)2.66987320
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66612949
87positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.66030598
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.65214685
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.63409493
90termination of RNA polymerase III transcription (GO:0006386)2.63409493
91protein peptidyl-prolyl isomerization (GO:0000413)2.63108296
92positive regulation of natural killer cell mediated immunity (GO:0002717)2.62193834
93T cell migration (GO:0072678)2.62110610
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61305432
95response to interferon-beta (GO:0035456)2.60729147
96pseudouridine synthesis (GO:0001522)2.59261191
97ATP biosynthetic process (GO:0006754)2.59217428
98positive regulation of calcium-mediated signaling (GO:0050850)2.58322733
99positive regulation of defense response to virus by host (GO:0002230)2.57918012
100purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56164250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11566098
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94161951
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.92522389
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.55602787
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.47546774
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42138468
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90567229
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.89604576
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86451918
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76140261
11VDR_22108803_ChIP-Seq_LS180_Human2.73486027
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52560641
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.50944358
14VDR_23849224_ChIP-Seq_CD4+_Human2.47554435
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47178927
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.14684124
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.06088128
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00905361
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.98621100
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96743409
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94805637
22ZNF274_21170338_ChIP-Seq_K562_Hela1.93154422
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89322305
24FOXP3_21729870_ChIP-Seq_TREG_Human1.87946228
25ELK1_19687146_ChIP-ChIP_HELA_Human1.85065701
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.70864951
27EZH2_22144423_ChIP-Seq_EOC_Human1.69120425
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63823662
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61962828
30MYB_26560356_Chip-Seq_TH2_Human1.58739977
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53083695
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49384595
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48305563
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.48098646
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46790471
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46500921
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42143615
38MYC_18940864_ChIP-ChIP_HL60_Human1.42109664
39TP53_22573176_ChIP-Seq_HFKS_Human1.33650525
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32499750
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31587994
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30847736
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30408414
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29866990
45IGF1R_20145208_ChIP-Seq_DFB_Human1.27937009
46GATA3_26560356_Chip-Seq_TH2_Human1.27755913
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27153455
48AR_20517297_ChIP-Seq_VCAP_Human1.26967832
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26886154
50HTT_18923047_ChIP-ChIP_STHdh_Human1.26233937
51EWS_26573619_Chip-Seq_HEK293_Human1.25063907
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.22976536
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22976536
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22219039
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.22017037
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21673152
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.21205033
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.20283584
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19805066
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19501220
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.19085056
62NCOR_22424771_ChIP-Seq_293T_Human1.18665165
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16131649
64GATA3_27048872_Chip-Seq_THYMUS_Human1.13030018
65NANOG_20526341_ChIP-Seq_ESCs_Human1.12956266
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11146750
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10438203
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10294258
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10202489
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08926522
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08452834
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.07853723
73SOX2_19829295_ChIP-Seq_ESCs_Human1.07799740
74NANOG_19829295_ChIP-Seq_ESCs_Human1.07799740
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.07403002
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07335022
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05904515
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05462091
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04181541
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03515118
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02663647
82ERG_20517297_ChIP-Seq_VCAP_Human1.00961448
83GABP_19822575_ChIP-Seq_HepG2_Human1.00911914
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00637636
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00338258
86RUNX_20019798_ChIP-Seq_JUKART_Human0.99996626
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99974037
88TAF2_19829295_ChIP-Seq_ESCs_Human0.99559598
89ER_23166858_ChIP-Seq_MCF-7_Human0.98593084
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97389701
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97165555
92DCP1A_22483619_ChIP-Seq_HELA_Human0.96507386
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95529003
94P300_19829295_ChIP-Seq_ESCs_Human0.94747601
95MYC_19829295_ChIP-Seq_ESCs_Human0.93379021
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92963298
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92524765
98ERA_21632823_ChIP-Seq_H3396_Human0.91647180
99CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91545203
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90382038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.21580376
2MP0009785_altered_susceptibility_to2.83585387
3MP0001835_abnormal_antigen_presentation2.60531823
4MP0006072_abnormal_retinal_apoptosis2.40740393
5MP0002166_altered_tumor_susceptibility2.32174944
6MP0002102_abnormal_ear_morphology2.30455779
7MP0008872_abnormal_physiological_respon2.28463759
8MP0000685_abnormal_immune_system2.22309562
9MP0005387_immune_system_phenotype2.12952253
10MP0001790_abnormal_immune_system2.12952253
11MP0003646_muscle_fatigue2.10397291
12MP0005377_hearing/vestibular/ear_phenot2.03424077
13MP0003878_abnormal_ear_physiology2.03424077
14MP0002006_tumorigenesis1.92605838
15MP0002148_abnormal_hypersensitivity_rea1.89319534
16MP0005000_abnormal_immune_tolerance1.85710703
17MP0001800_abnormal_humoral_immune1.83585201
18MP0009379_abnormal_foot_pigmentation1.82701431
19MP0002138_abnormal_hepatobiliary_system1.77591330
20MP0003763_abnormal_thymus_physiology1.76943791
21MP0004147_increased_porphyrin_level1.75403667
22MP0006036_abnormal_mitochondrial_physio1.74923856
23MP0008875_abnormal_xenobiotic_pharmacok1.74733043
24MP0005025_abnormal_response_to1.69973524
25MP0009333_abnormal_splenocyte_physiolog1.69168141
26MP0002420_abnormal_adaptive_immunity1.64577300
27MP0005645_abnormal_hypothalamus_physiol1.64358091
28MP0000372_irregular_coat_pigmentation1.61227904
29MP0001819_abnormal_immune_cell1.60694340
30MP0002653_abnormal_ependyma_morphology1.59486224
31MP0002723_abnormal_immune_serum1.59055932
32MP0006292_abnormal_olfactory_placode1.58940464
33MP0005084_abnormal_gallbladder_morpholo1.58207775
34MP0002933_joint_inflammation1.55211727
35MP0005551_abnormal_eye_electrophysiolog1.51007747
36MP0006082_CNS_inflammation1.46945853
37MP0001905_abnormal_dopamine_level1.46768499
38MP0003195_calcinosis1.45199260
39MP0002837_dystrophic_cardiac_calcinosis1.42625017
40MP0003866_abnormal_defecation1.41324569
41MP0006035_abnormal_mitochondrial_morpho1.40968816
42MP0008877_abnormal_DNA_methylation1.40550881
43MP0002736_abnormal_nociception_after1.40518053
44MP0001873_stomach_inflammation1.40380071
45MP0003786_premature_aging1.39544401
46MP0001485_abnormal_pinna_reflex1.38951020
47MP0002163_abnormal_gland_morphology1.35783707
48MP0004142_abnormal_muscle_tone1.35022287
49MP0002452_abnormal_antigen_presenting1.32584962
50MP0001968_abnormal_touch/_nociception1.32436264
51MP0000716_abnormal_immune_system1.24958537
52MP0005253_abnormal_eye_physiology1.19260376
53MP0009697_abnormal_copulation1.19122666
54MP0002277_abnormal_respiratory_mucosa1.17566113
55MP0008058_abnormal_DNA_repair1.16689364
56MP0009764_decreased_sensitivity_to1.13110570
57MP0002398_abnormal_bone_marrow1.10525163
58MP0010155_abnormal_intestine_physiology1.09252307
59MP0002405_respiratory_system_inflammati1.06785979
60MP0000689_abnormal_spleen_morphology1.04860917
61MP0005646_abnormal_pituitary_gland1.04656024
62MP0002722_abnormal_immune_system1.04105341
63MP0002876_abnormal_thyroid_physiology1.03144780
64MP0003137_abnormal_impulse_conducting1.02995768
65MP0005410_abnormal_fertilization1.02976401
66MP0001986_abnormal_taste_sensitivity1.02395335
67MP0004885_abnormal_endolymph0.98704679
68MP0004742_abnormal_vestibular_system0.97224529
69MP0004145_abnormal_muscle_electrophysio0.97199330
70MP0001529_abnormal_vocalization0.96791256
71MP0001348_abnormal_lacrimal_gland0.95772692
72MP0000703_abnormal_thymus_morphology0.95632338
73MP0001919_abnormal_reproductive_system0.95331799
74MP0006276_abnormal_autonomic_nervous0.95240190
75MP0002429_abnormal_blood_cell0.94551212
76MP0001845_abnormal_inflammatory_respons0.92519143
77MP0002095_abnormal_skin_pigmentation0.91594079
78MP0001501_abnormal_sleep_pattern0.91275170
79MP0005636_abnormal_mineral_homeostasis0.90942371
80MP0003186_abnormal_redox_activity0.89080115
81MP0003252_abnormal_bile_duct0.87313281
82MP0005379_endocrine/exocrine_gland_phen0.86971615
83MP0004957_abnormal_blastocyst_morpholog0.86289270
84MP0003693_abnormal_embryo_hatching0.85034390
85MP0005389_reproductive_system_phenotype0.84066695
86MP0002419_abnormal_innate_immunity0.82971707
87MP0001119_abnormal_female_reproductive0.82938936
88MP0010094_abnormal_chromosome_stability0.80605066
89MP0002272_abnormal_nervous_system0.80210449
90MP0002733_abnormal_thermal_nociception0.79557805
91MP0003880_abnormal_central_pattern0.78554852
92MP0004043_abnormal_pH_regulation0.78101722
93MP0003718_maternal_effect0.76842282
94MP0003448_altered_tumor_morphology0.76511685
95MP0003724_increased_susceptibility_to0.75873386
96MP0008469_abnormal_protein_level0.75397856
97MP0010386_abnormal_urinary_bladder0.75006028
98MP0003567_abnormal_fetal_cardiomyocyte0.74971118
99MP0005075_abnormal_melanosome_morpholog0.73964342
100MP0002693_abnormal_pancreas_physiology0.71853319

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.75811197
2Acute necrotizing encephalopathy (HP:0006965)4.66258638
3Hepatocellular necrosis (HP:0001404)4.53980669
4Abnormal mitochondria in muscle tissue (HP:0008316)4.37609127
5Abnormality of B cell number (HP:0010975)4.21003351
6Hepatic necrosis (HP:0002605)4.12719825
7Increased CSF lactate (HP:0002490)4.08491406
8Acute encephalopathy (HP:0006846)3.98993209
93-Methylglutaconic aciduria (HP:0003535)3.98015439
10Hypoproteinemia (HP:0003075)3.95291485
11Severe combined immunodeficiency (HP:0004430)3.93674345
12IgG deficiency (HP:0004315)3.83159819
13Increased hepatocellular lipid droplets (HP:0006565)3.77498486
14Progressive macrocephaly (HP:0004481)3.76687897
15Aplastic anemia (HP:0001915)3.62226682
16Congenital stationary night blindness (HP:0007642)3.60131010
17Elevated erythrocyte sedimentation rate (HP:0003565)3.58229201
18Lipid accumulation in hepatocytes (HP:0006561)3.45614096
19Increased IgM level (HP:0003496)3.41290488
20Increased intramyocellular lipid droplets (HP:0012240)3.38488347
21Autoimmune hemolytic anemia (HP:0001890)3.35272859
22B lymphocytopenia (HP:0010976)3.31460557
23Abnormality of T cell number (HP:0011839)3.27296213
24Cerebral edema (HP:0002181)3.22818335
25Renal Fanconi syndrome (HP:0001994)3.16001215
26Combined immunodeficiency (HP:0005387)3.08945355
27Eosinophilia (HP:0001880)2.99318321
28Autoimmune thrombocytopenia (HP:0001973)2.98339501
29Thyroiditis (HP:0100646)2.96353475
30T lymphocytopenia (HP:0005403)2.95403063
31Abnormality of eosinophils (HP:0001879)2.88985800
32Increased muscle lipid content (HP:0009058)2.86069769
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85286280
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84549135
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84549135
36Increased serum lactate (HP:0002151)2.81477218
37Lactic acidosis (HP:0003128)2.67419263
38Panhypogammaglobulinemia (HP:0003139)2.63124119
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59782697
40Respiratory failure (HP:0002878)2.57143452
41Optic disc pallor (HP:0000543)2.56232489
42Colon cancer (HP:0003003)2.51240685
43Abnormality of T cells (HP:0002843)2.50383953
44Pancytopenia (HP:0001876)2.48189699
45Pancreatic cysts (HP:0001737)2.46460872
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.33828353
47Reticulocytopenia (HP:0001896)2.32004579
48Exertional dyspnea (HP:0002875)2.31875824
49Exercise intolerance (HP:0003546)2.30241043
50Granulocytopenia (HP:0001913)2.28693215
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28562787
52Stomach cancer (HP:0012126)2.27202064
53Pancreatic fibrosis (HP:0100732)2.26317342
54True hermaphroditism (HP:0010459)2.22892212
55Lethargy (HP:0001254)2.19668234
56Hypoplasia of the thymus (HP:0000778)2.18337351
57Abnormality of midbrain morphology (HP:0002418)2.13403203
58Molar tooth sign on MRI (HP:0002419)2.13403203
59Generalized aminoaciduria (HP:0002909)2.10682070
60Type I transferrin isoform profile (HP:0003642)2.10027000
61Renal cortical cysts (HP:0000803)2.08028566
62Erythroderma (HP:0001019)2.07953947
63Hyperglycinemia (HP:0002154)2.07683481
64Leukodystrophy (HP:0002415)2.06159869
65Dicarboxylic aciduria (HP:0003215)2.05090679
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05090679
67Abnormality of the renal cortex (HP:0011035)2.01516088
68Abnormal delayed hypersensitivity skin test (HP:0002963)1.99412507
69Abnormality of the ileum (HP:0001549)1.97783316
70Leukocytosis (HP:0001974)1.96982275
71Methylmalonic acidemia (HP:0002912)1.93918158
72Attenuation of retinal blood vessels (HP:0007843)1.93357694
73Abnormal albumin level (HP:0012116)1.91888864
74Hypoalbuminemia (HP:0003073)1.91888864
75Respiratory difficulties (HP:0002880)1.90541627
76Stomatitis (HP:0010280)1.90346133
77Hyperphosphaturia (HP:0003109)1.89899459
78CNS demyelination (HP:0007305)1.89300389
79Methylmalonic aciduria (HP:0012120)1.88324670
80Meckel diverticulum (HP:0002245)1.88311564
81Parakeratosis (HP:0001036)1.88284485
82Cellular immunodeficiency (HP:0005374)1.88130539
83Abnormality of renal resorption (HP:0011038)1.88016205
84Agammaglobulinemia (HP:0004432)1.87816998
85Abolished electroretinogram (ERG) (HP:0000550)1.87146090
86Abnormal rod and cone electroretinograms (HP:0008323)1.84981916
87Constricted visual fields (HP:0001133)1.84016587
88Abnormality of urine glucose concentration (HP:0011016)1.81976103
89Glycosuria (HP:0003076)1.81976103
90Chronic diarrhea (HP:0002028)1.81954402
91Decreased central vision (HP:0007663)1.79234578
92Absent thumb (HP:0009777)1.78763790
93Abnormality of T cell physiology (HP:0011840)1.77092334
94Recurrent bronchitis (HP:0002837)1.76356162
95Abnormality of the prostate (HP:0008775)1.75166519
96Emotional lability (HP:0000712)1.74541863
97Stenosis of the external auditory canal (HP:0000402)1.73589794
98Type 2 muscle fiber atrophy (HP:0003554)1.73215314
99Nephronophthisis (HP:0000090)1.72419912
100Aplasia/hypoplasia of the uterus (HP:0008684)1.69796528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.42827536
2TESK25.08896903
3VRK24.23848212
4TXK3.73001581
5BCKDK3.10141455
6ZAK2.78602362
7MAP3K122.55921021
8GRK12.34068408
9TIE12.17663428
10LIMK12.08157710
11MAP4K22.02318429
12BUB11.97614842
13VRK11.97309127
14TAOK31.89656333
15MUSK1.85252214
16MST41.85236564
17TESK11.78026802
18PINK11.72963679
19ADRBK21.62466307
20SRPK11.57954389
21DAPK11.50893628
22MAP4K11.47896182
23STK161.46598551
24ITK1.36239896
25NME11.34574545
26TRIM281.20340298
27WNK31.18014941
28TEC1.16515387
29MYLK1.12347549
30CDK191.11396912
31EIF2AK31.11023513
32MAP3K111.09871464
33MAPKAPK31.08546423
34NUAK11.08249878
35TLK11.07918863
36NEK11.06190121
37GRK61.02386244
38WNK40.94179295
39TAF10.91843862
40DYRK20.90509255
41FRK0.88107292
42BMPR1B0.84048960
43INSRR0.82654159
44OXSR10.79087540
45SYK0.77209528
46CAMKK20.76351257
47FES0.75372779
48PASK0.74393985
49PRKCQ0.73873011
50CSNK1G30.70682031
51BTK0.69638664
52PIM20.69523875
53MAP2K70.69308552
54LCK0.64580648
55CDC70.62848468
56IKBKB0.60078574
57MAPK130.59376794
58LYN0.57592895
59BCR0.56184924
60CSNK1G10.55788136
61GRK70.55466562
62SCYL20.53839262
63PLK30.52402206
64CSNK1A1L0.49863894
65PLK20.49027110
66MAPKAPK50.47856550
67RPS6KA50.47707507
68CSF1R0.46910427
69KIT0.46832015
70CSNK1G20.46536431
71ADRBK10.44763390
72GRK50.44402000
73IGF1R0.42790869
74TNK20.42340867
75DAPK30.41275634
76PIM10.40806741
77MAP3K40.40687472
78PIK3CA0.39649582
79ERBB30.39510738
80PIK3CG0.39371540
81CSNK2A10.38306600
82EIF2AK20.37376128
83OBSCN0.35717440
84STK390.33912636
85NME20.33252626
86CSK0.32523471
87PLK40.31696866
88ROCK10.31192501
89CSNK2A20.30927739
90AURKA0.30160205
91ATR0.29783061
92PHKG10.29647532
93PHKG20.29647532
94JAK30.29454254
95PLK10.29063702
96PRKCA0.28600716
97PRKACA0.27785400
98MAP2K60.26817577
99CAMK2A0.26699181
100LRRK20.26607827

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.16286666
2Primary immunodeficiency_Homo sapiens_hsa053404.05664389
3Oxidative phosphorylation_Homo sapiens_hsa001904.02547267
4Parkinsons disease_Homo sapiens_hsa050123.42870941
5Ribosome_Homo sapiens_hsa030103.15752415
6Protein export_Homo sapiens_hsa030602.62136705
7RNA polymerase_Homo sapiens_hsa030202.36566416
8Alzheimers disease_Homo sapiens_hsa050102.25648990
9Huntingtons disease_Homo sapiens_hsa050162.22872154
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99306684
11Graft-versus-host disease_Homo sapiens_hsa053321.91067867
12Antigen processing and presentation_Homo sapiens_hsa046121.81421492
13Autoimmune thyroid disease_Homo sapiens_hsa053201.80734364
14Allograft rejection_Homo sapiens_hsa053301.74300728
15Cardiac muscle contraction_Homo sapiens_hsa042601.72142934
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70137047
17Phototransduction_Homo sapiens_hsa047441.63945222
18Hematopoietic cell lineage_Homo sapiens_hsa046401.59479752
19Propanoate metabolism_Homo sapiens_hsa006401.55868395
20Caffeine metabolism_Homo sapiens_hsa002321.51829842
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51053108
22Type I diabetes mellitus_Homo sapiens_hsa049401.36914954
23Homologous recombination_Homo sapiens_hsa034401.36425832
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35439880
25DNA replication_Homo sapiens_hsa030301.34971337
26Pyrimidine metabolism_Homo sapiens_hsa002401.30996925
27Mismatch repair_Homo sapiens_hsa034301.27668066
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26461817
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.26039080
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25875218
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24580673
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20914269
33RNA degradation_Homo sapiens_hsa030181.18347804
34Asthma_Homo sapiens_hsa053101.12425295
35Nitrogen metabolism_Homo sapiens_hsa009101.11263082
36One carbon pool by folate_Homo sapiens_hsa006701.08402473
37Peroxisome_Homo sapiens_hsa041461.07905023
38Basal transcription factors_Homo sapiens_hsa030221.05211158
39Nucleotide excision repair_Homo sapiens_hsa034201.05127783
40Base excision repair_Homo sapiens_hsa034101.04866381
41Purine metabolism_Homo sapiens_hsa002301.03830991
42Butanoate metabolism_Homo sapiens_hsa006501.03803287
43Rheumatoid arthritis_Homo sapiens_hsa053231.00904138
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00831107
45Fanconi anemia pathway_Homo sapiens_hsa034601.00387908
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95115853
47Spliceosome_Homo sapiens_hsa030400.88288997
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86974147
49T cell receptor signaling pathway_Homo sapiens_hsa046600.86627995
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80653138
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79993135
52Sulfur metabolism_Homo sapiens_hsa009200.78633433
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78283109
54Linoleic acid metabolism_Homo sapiens_hsa005910.73946384
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71450369
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68748897
57Tryptophan metabolism_Homo sapiens_hsa003800.68602718
58RNA transport_Homo sapiens_hsa030130.68354985
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66774768
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63689110
61Metabolic pathways_Homo sapiens_hsa011000.63202615
62Chemical carcinogenesis_Homo sapiens_hsa052040.62565633
63Glutathione metabolism_Homo sapiens_hsa004800.60591464
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60555848
65Retinol metabolism_Homo sapiens_hsa008300.59655450
66Fatty acid elongation_Homo sapiens_hsa000620.56942443
67Pyruvate metabolism_Homo sapiens_hsa006200.54657264
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53783983
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.53552032
70Steroid biosynthesis_Homo sapiens_hsa001000.52935087
71Malaria_Homo sapiens_hsa051440.52725364
72Measles_Homo sapiens_hsa051620.52288010
73Collecting duct acid secretion_Homo sapiens_hsa049660.51164915
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50584902
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.49380528
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48542126
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47925066
78Olfactory transduction_Homo sapiens_hsa047400.47749022
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.47073252
80Shigellosis_Homo sapiens_hsa051310.45883879
81Systemic lupus erythematosus_Homo sapiens_hsa053220.44884380
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44082634
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.43280159
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42885927
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41853276
86Fatty acid degradation_Homo sapiens_hsa000710.39101087
87Salmonella infection_Homo sapiens_hsa051320.39062350
88Fatty acid metabolism_Homo sapiens_hsa012120.38560834
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38489737
90Viral myocarditis_Homo sapiens_hsa054160.37607721
91Non-homologous end-joining_Homo sapiens_hsa034500.36385276
92Arachidonic acid metabolism_Homo sapiens_hsa005900.34629049
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33382153
94beta-Alanine metabolism_Homo sapiens_hsa004100.32797091
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.31648110
96Regulation of autophagy_Homo sapiens_hsa041400.30683048
97Epstein-Barr virus infection_Homo sapiens_hsa051690.29151186
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28355595
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27496496
100Taste transduction_Homo sapiens_hsa047420.27025224

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