ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tryptophan metabolic process (GO:0006568)	5.51355053
2	lysine metabolic process (GO:0006553)	5.06639571
3	lysine catabolic process (GO:0006554)	5.06639571
4	indolalkylamine metabolic process (GO:0006586)	4.81472526
5	cullin deneddylation (GO:0010388)	4.40480330
6	neurotransmitter uptake (GO:0001504)	4.35809238
7	protein deneddylation (GO:0000338)	4.23812906
8	IMP biosynthetic process (GO:0006188)	4.19892092
9	regulation of cilium movement (GO:0003352)	3.95670684
10	DNA damage response, detection of DNA damage (GO:0042769)	3.85995747
11	DNA double-strand break processing (GO:0000729)	3.83170050
12	presynaptic membrane assembly (GO:0097105)	3.81855481
13	aspartate family amino acid catabolic process (GO:0009068)	3.73608766
14	branched-chain amino acid catabolic process (GO:0009083)	3.70661317
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.69747771
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.69469379
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.69469379
18	indole-containing compound metabolic process (GO:0042430)	3.68097757
19	nonmotile primary cilium assembly (GO:0035058)	3.63030746
20	muscle organ morphogenesis (GO:0048644)	3.61292263
21	postsynaptic membrane organization (GO:0001941)	3.60434019
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.59130743
23	NADH dehydrogenase complex assembly (GO:0010257)	3.59130743
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.59130743
25	piRNA metabolic process (GO:0034587)	3.58783425
26	DNA methylation involved in gamete generation (GO:0043046)	3.47916311
27	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.44975778
28	IMP metabolic process (GO:0046040)	3.43861393
29	primary amino compound metabolic process (GO:1901160)	3.43236185
30	regulation of memory T cell differentiation (GO:0043380)	3.40696586
31	response to lipoprotein particle (GO:0055094)	3.40440203
32	positive regulation of mitochondrial fission (GO:0090141)	3.36550571
33	dicarboxylic acid catabolic process (GO:0043649)	3.32846830
34	DNA deamination (GO:0045006)	3.25737341
35	tRNA methylation (GO:0030488)	3.25538615
36	protein complex biogenesis (GO:0070271)	3.23023517
37	regulation of helicase activity (GO:0051095)	3.22788935
38	purine nucleobase biosynthetic process (GO:0009113)	3.21922246
39	intracellular protein transmembrane import (GO:0044743)	3.21327685
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20593912
41	resolution of meiotic recombination intermediates (GO:0000712)	3.20011217
42	protein localization to peroxisome (GO:0072662)	3.19973834
43	protein targeting to peroxisome (GO:0006625)	3.19973834
44	establishment of protein localization to peroxisome (GO:0072663)	3.19973834
45	pseudouridine synthesis (GO:0001522)	3.19668719
46	ubiquinone biosynthetic process (GO:0006744)	3.16514909
47	DNA catabolic process, exonucleolytic (GO:0000738)	3.15284753
48	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.14408173
49	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.14397269
50	protein-cofactor linkage (GO:0018065)	3.11440000
51	replication fork processing (GO:0031297)	3.08705682
52	somite development (GO:0061053)	3.08510300
53	presynaptic membrane organization (GO:0097090)	3.07256749
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06746348
55	regulation of female receptivity (GO:0045924)	3.05080573
56	adenosine metabolic process (GO:0046085)	3.03263606
57	transmission of nerve impulse (GO:0019226)	3.02169556
58	positive regulation of RNA splicing (GO:0033120)	3.01205007
59	epithelial cilium movement (GO:0003351)	3.00674531
60	peptidyl-arginine omega-N-methylation (GO:0035247)	2.96848324
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.94130615
62	maturation of 5.8S rRNA (GO:0000460)	2.91560378
63	glutamine metabolic process (GO:0006541)	2.89258483
64	ubiquinone metabolic process (GO:0006743)	2.89132055
65	tRNA processing (GO:0008033)	2.88199595
66	nucleobase biosynthetic process (GO:0046112)	2.85909937
67	peroxisomal transport (GO:0043574)	2.84302108
68	fusion of sperm to egg plasma membrane (GO:0007342)	2.81797633
69	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.79501502
70	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.78869461
71	intra-S DNA damage checkpoint (GO:0031573)	2.78048939
72	branched-chain amino acid metabolic process (GO:0009081)	2.76811853
73	aromatic amino acid family metabolic process (GO:0009072)	2.73889319
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.73022920
75	mismatch repair (GO:0006298)	2.71869436
76	regulation of microtubule-based movement (GO:0060632)	2.71397698
77	male meiosis (GO:0007140)	2.70205381
78	tRNA metabolic process (GO:0006399)	2.70091935
79	positive regulation of male gonad development (GO:2000020)	2.64996445
80	negative regulation of thymocyte apoptotic process (GO:0070244)	2.62327444
81	cellular response to interferon-beta (GO:0035458)	2.62269048
82	serotonin metabolic process (GO:0042428)	2.59707475
83	organic cation transport (GO:0015695)	2.59671804
84	kynurenine metabolic process (GO:0070189)	2.59541503
85	axonemal dynein complex assembly (GO:0070286)	2.59021757
86	termination of RNA polymerase I transcription (GO:0006363)	2.58750261
87	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.58419591
88	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.57463636
89	regulation of regulatory T cell differentiation (GO:0045589)	2.56602103
90	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.56173174
91	nucleotide transmembrane transport (GO:1901679)	2.55253940
92	glycerol ether metabolic process (GO:0006662)	2.54011514
93	tryptophan catabolic process (GO:0006569)	2.52431474
94	indole-containing compound catabolic process (GO:0042436)	2.52431474
95	indolalkylamine catabolic process (GO:0046218)	2.52431474
96	ether lipid metabolic process (GO:0046485)	2.51967974
97	magnesium ion transport (GO:0015693)	2.50005770
98	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.48586239
99	intra-Golgi vesicle-mediated transport (GO:0006891)	2.47440539
100	rRNA catabolic process (GO:0016075)	2.45399167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.86256612
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84497548
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.57843202
4	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.05359961
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93723443
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.90426126
7	VDR_22108803_ChIP-Seq_LS180_Human	2.63005230
8	FUS_26573619_Chip-Seq_HEK293_Human	2.49708916
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47095878
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.46293484
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34884978
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.32572253
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.28580953
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.27049639
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.13744005
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.13000695
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00060707
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94539645
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87684650
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83774951
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.82926788
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76321041
23	EWS_26573619_Chip-Seq_HEK293_Human	1.75887103
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74054583
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.72289362
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.72185396
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.70992292
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.69623264
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69623264
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.67780193
31	P300_19829295_ChIP-Seq_ESCs_Human	1.66858074
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.64020535
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63750651
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63053617
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.60967347
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59848970
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.58382172
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.57085527
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54839208
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.54175731
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.50196544
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49547728
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40320474
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38829337
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38829337
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35989967
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35074736
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35053681
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35039944
50	EZH2_22144423_ChIP-Seq_EOC_Human	1.34910551
51	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34675747
52	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32885008
53	CIITA_25753668_ChIP-Seq_RAJI_Human	1.30601429
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27872993
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.23454888
56	TTF2_22483619_ChIP-Seq_HELA_Human	1.23020227
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21423826
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19811949
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19152558
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19152558
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18280359
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17857589
63	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17214828
64	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.15265059
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.15170492
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13796049
67	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11200742
68	NCOR_22424771_ChIP-Seq_293T_Human	1.08813792
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08052540
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.07249603
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07226795
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06927359
73	STAT3_23295773_ChIP-Seq_U87_Human	1.06447458
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06397624
75	AR_20517297_ChIP-Seq_VCAP_Human	1.05866873
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.05743654
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05457984
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04876171
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04876171
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04863456
81	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04691042
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04071650
83	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04014860
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.03803106
85	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.03379296
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03072657
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03042448
88	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02784607
89	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02002446
90	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01506889
91	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.01353738
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01142185
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00312516
94	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.99050530
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.98690189
96	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98266929
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97945346
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97418273
99	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.96517746
100	TCF4_23295773_ChIP-Seq_U87_Human	0.95212199

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.36979876
2	MP0003136_yellow_coat_color	3.89877118
3	MP0004147_increased_porphyrin_level	3.82452910
4	MP0000372_irregular_coat_pigmentation	3.33533973
5	MP0009780_abnormal_chondrocyte_physiolo	3.21427226
6	MP0001529_abnormal_vocalization	2.91379860
7	MP0000383_abnormal_hair_follicle	2.88936919
8	MP0002163_abnormal_gland_morphology	2.88696600
9	MP0006276_abnormal_autonomic_nervous	2.47600476
10	MP0003878_abnormal_ear_physiology	2.43595319
11	MP0005377_hearing/vestibular/ear_phenot	2.43595319
12	MP0006054_spinal_hemorrhage	2.25735883
13	MP0000569_abnormal_digit_pigmentation	2.22145571
14	MP0005171_absent_coat_pigmentation	2.19006248
15	MP0002102_abnormal_ear_morphology	2.13022368
16	MP0006292_abnormal_olfactory_placode	2.06911913
17	MP0003693_abnormal_embryo_hatching	2.05075154
18	MP0005646_abnormal_pituitary_gland	2.00447191
19	MP0002837_dystrophic_cardiac_calcinosis	1.92505575
20	MP0006072_abnormal_retinal_apoptosis	1.86683937
21	MP0010678_abnormal_skin_adnexa	1.83655984
22	MP0005379_endocrine/exocrine_gland_phen	1.83558747
23	MP0006036_abnormal_mitochondrial_physio	1.79036984
24	MP0005253_abnormal_eye_physiology	1.72646877
25	MP0006035_abnormal_mitochondrial_morpho	1.70672263
26	MP0001968_abnormal_touch/_nociception	1.67693643
27	MP0001984_abnormal_olfaction	1.63151316
28	MP0008789_abnormal_olfactory_epithelium	1.59064641
29	MP0005551_abnormal_eye_electrophysiolog	1.55276644
30	MP0002090_abnormal_vision	1.50070443
31	MP0009697_abnormal_copulation	1.49701871
32	MP0008872_abnormal_physiological_respon	1.46897949
33	MP0002736_abnormal_nociception_after	1.46802940
34	MP0004885_abnormal_endolymph	1.44816994
35	MP0000049_abnormal_middle_ear	1.42124987
36	MP0002938_white_spotting	1.38053103
37	MP0000647_abnormal_sebaceous_gland	1.37261462
38	MP0010094_abnormal_chromosome_stability	1.35983119
39	MP0003786_premature_aging	1.23835023
40	MP0002282_abnormal_trachea_morphology	1.16061581
41	MP0003221_abnormal_cardiomyocyte_apopto	1.13969931
42	MP0004215_abnormal_myocardial_fiber	1.13775713
43	MP0004484_altered_response_of	1.13525702
44	MP0008877_abnormal_DNA_methylation	1.10253762
45	MP0008875_abnormal_xenobiotic_pharmacok	1.10216251
46	MP0003806_abnormal_nucleotide_metabolis	1.10176983
47	MP0000358_abnormal_cell_content/	1.09841762
48	MP0001293_anophthalmia	1.04827888
49	MP0003937_abnormal_limbs/digits/tail_de	1.04399577
50	MP0000631_abnormal_neuroendocrine_gland	1.03562174
51	MP0002127_abnormal_cardiovascular_syste	1.02147225
52	MP0000467_abnormal_esophagus_morphology	1.02039325
53	MP0002210_abnormal_sex_determination	1.00107344
54	MP0003567_abnormal_fetal_cardiomyocyte	0.99276683
55	MP0002653_abnormal_ependyma_morphology	0.97937302
56	MP0002751_abnormal_autonomic_nervous	0.97124504
57	MP0001661_extended_life_span	0.96166858
58	MP0008058_abnormal_DNA_repair	0.91338290
59	MP0005332_abnormal_amino_acid	0.90164749
60	MP0001764_abnormal_homeostasis	0.90002221
61	MP0000013_abnormal_adipose_tissue	0.89403247
62	MP0003698_abnormal_male_reproductive	0.89183678
63	MP0001929_abnormal_gametogenesis	0.88369546
64	MP0003718_maternal_effect	0.87286104
65	MP0003938_abnormal_ear_development	0.86285646
66	MP0001188_hyperpigmentation	0.84680673
67	MP0005499_abnormal_olfactory_system	0.83498941
68	MP0005394_taste/olfaction_phenotype	0.83498941
69	MP0005391_vision/eye_phenotype	0.82522879
70	MP0009745_abnormal_behavioral_response	0.81539579
71	MP0002572_abnormal_emotion/affect_behav	0.81143589
72	MP0005410_abnormal_fertilization	0.81127083
73	MP0005636_abnormal_mineral_homeostasis	0.79575539
74	MP0002272_abnormal_nervous_system	0.79203100
75	MP0005084_abnormal_gallbladder_morpholo	0.78560947
76	MP0001485_abnormal_pinna_reflex	0.77931379
77	MP0000653_abnormal_sex_gland	0.77589782
78	MP0008932_abnormal_embryonic_tissue	0.76693915
79	MP0005647_abnormal_sex_gland	0.74915574
80	MP0003186_abnormal_redox_activity	0.72959174
81	MP0005584_abnormal_enzyme/coenzyme_acti	0.72823572
82	MP0000230_abnormal_systemic_arterial	0.72330144
83	MP0001145_abnormal_male_reproductive	0.71843582
84	MP0003633_abnormal_nervous_system	0.70121520
85	MP0000427_abnormal_hair_cycle	0.69439183
86	MP0003119_abnormal_digestive_system	0.69138067
87	MP0000579_abnormal_nail_morphology	0.68910727
88	MP0009053_abnormal_anal_canal	0.68003873
89	MP0005083_abnormal_biliary_tract	0.65550680
90	MP0002229_neurodegeneration	0.65055336
91	MP0005367_renal/urinary_system_phenotyp	0.64521688
92	MP0000516_abnormal_urinary_system	0.64521688
93	MP0005195_abnormal_posterior_eye	0.63370649
94	MP0002067_abnormal_sensory_capabilities	0.62969422
95	MP0005167_abnormal_blood-brain_barrier	0.62160158
96	MP0004957_abnormal_blastocyst_morpholog	0.62135910
97	MP0002249_abnormal_larynx_morphology	0.61773702
98	MP0001963_abnormal_hearing_physiology	0.61706809
99	MP0004085_abnormal_heartbeat	0.61506576
100	MP0000026_abnormal_inner_ear	0.60604777

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.95553363
2	Pancreatic cysts (HP:0001737)	3.65741351
3	CNS hypomyelination (HP:0003429)	3.41346844
4	Abnormality of midbrain morphology (HP:0002418)	3.31510346
5	Molar tooth sign on MRI (HP:0002419)	3.31510346
6	Pancreatic fibrosis (HP:0100732)	3.21815238
7	Abnormality of lateral ventricle (HP:0030047)	3.15779554
8	Opisthotonus (HP:0002179)	3.09963513
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.07200023
10	3-Methylglutaconic aciduria (HP:0003535)	2.99971228
11	Microvesicular hepatic steatosis (HP:0001414)	2.98155220
12	Attenuation of retinal blood vessels (HP:0007843)	2.92609393
13	Carpal bone hypoplasia (HP:0001498)	2.87342428
14	Absent/shortened dynein arms (HP:0200106)	2.78046628
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78046628
16	Abnormal respiratory motile cilium morphology (HP:0005938)	2.73050998
17	Abnormal respiratory epithelium morphology (HP:0012253)	2.73050998
18	Congenital primary aphakia (HP:0007707)	2.68169477
19	Median cleft lip (HP:0000161)	2.64388086
20	Gait imbalance (HP:0002141)	2.63025786
21	Increased serum pyruvate (HP:0003542)	2.62777256
22	Abnormality of glycolysis (HP:0004366)	2.60933764
23	Mesangial abnormality (HP:0001966)	2.56847405
24	Sex reversal (HP:0012245)	2.56574831
25	Abnormal sex determination (HP:0012244)	2.56574831
26	Spastic diplegia (HP:0001264)	2.56233340
27	Acute necrotizing encephalopathy (HP:0006965)	2.54416589
28	Long nose (HP:0003189)	2.49810193
29	Methylmalonic acidemia (HP:0002912)	2.49037461
30	Dicarboxylic aciduria (HP:0003215)	2.46894789
31	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.46894789
32	Medial flaring of the eyebrow (HP:0010747)	2.46472698
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42479018
34	Abnormality of alanine metabolism (HP:0010916)	2.42479018
35	Hyperalaninemia (HP:0003348)	2.42479018
36	Eosinophilia (HP:0001880)	2.40754777
37	Abnormal ciliary motility (HP:0012262)	2.37086366
38	Nephrogenic diabetes insipidus (HP:0009806)	2.34854176
39	Male pseudohermaphroditism (HP:0000037)	2.33761604
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33562390
41	Delayed CNS myelination (HP:0002188)	2.31409185
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.31215966
43	Abnormality of cochlea (HP:0000375)	2.31146243
44	Aplasia/hypoplasia of the uterus (HP:0008684)	2.31060618
45	Progressive inability to walk (HP:0002505)	2.24702970
46	Mitochondrial inheritance (HP:0001427)	2.22371685
47	Neonatal respiratory distress (HP:0002643)	2.21310048
48	Short tibia (HP:0005736)	2.17894570
49	Progressive macrocephaly (HP:0004481)	2.14575010
50	Acute encephalopathy (HP:0006846)	2.09991355
51	Hematochezia (HP:0002573)	2.09811904
52	Erythroderma (HP:0001019)	2.08480883
53	Sensorimotor neuropathy (HP:0007141)	2.08345106
54	Severe global developmental delay (HP:0011344)	2.07635586
55	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07566928
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07455909
57	Type II lissencephaly (HP:0007260)	2.06856887
58	Hypoproteinemia (HP:0003075)	2.06701828
59	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06113196
60	Bony spicule pigmentary retinopathy (HP:0007737)	2.05978619
61	Cystic liver disease (HP:0006706)	2.04911338
62	Increased CSF lactate (HP:0002490)	2.03914766
63	Methylmalonic aciduria (HP:0012120)	2.03087433
64	Pendular nystagmus (HP:0012043)	2.00933140
65	Gonadal dysgenesis (HP:0000133)	1.98764666
66	Abnormal biliary tract physiology (HP:0012439)	1.98119826
67	Bile duct proliferation (HP:0001408)	1.98119826
68	Abnormality of eosinophils (HP:0001879)	1.97486978
69	Postaxial foot polydactyly (HP:0001830)	1.95970850
70	Occipital encephalocele (HP:0002085)	1.95810479
71	Preaxial hand polydactyly (HP:0001177)	1.94435030
72	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.93230501
73	Abnormality of the columella (HP:0009929)	1.93055536
74	Fused cervical vertebrae (HP:0002949)	1.91810818
75	Agnosia (HP:0010524)	1.91434909
76	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.89993258
77	Granulocytopenia (HP:0001913)	1.89640839
78	Cerebral edema (HP:0002181)	1.89135695
79	Abnormality of the periventricular white matter (HP:0002518)	1.87526718
80	Short 1st metacarpal (HP:0010034)	1.86111515
81	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.86111515
82	Colon cancer (HP:0003003)	1.85991017
83	Aplasia/hypoplasia of the humerus (HP:0006507)	1.85655569
84	Poor speech (HP:0002465)	1.84757014
85	Status epilepticus (HP:0002133)	1.84073723
86	Congenital stationary night blindness (HP:0007642)	1.80168766
87	Inability to walk (HP:0002540)	1.80032556
88	Decreased central vision (HP:0007663)	1.79265063
89	Furrowed tongue (HP:0000221)	1.79237459
90	B lymphocytopenia (HP:0010976)	1.79203296
91	Lactic acidosis (HP:0003128)	1.79061815
92	Congenital hepatic fibrosis (HP:0002612)	1.78126767
93	Abnormality of the nasal septum (HP:0000419)	1.77979096
94	Paralysis (HP:0003470)	1.77807267
95	Postaxial hand polydactyly (HP:0001162)	1.77119060
96	Optic disc pallor (HP:0000543)	1.77059528
97	Thyroid-stimulating hormone excess (HP:0002925)	1.76945470
98	Genital tract atresia (HP:0001827)	1.76675480
99	Horseshoe kidney (HP:0000085)	1.76527914
100	Increased serum lactate (HP:0002151)	1.74888298

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.86055550
2	MST4	3.77371822
3	EIF2AK1	3.41885754
4	SRPK1	3.00159898
5	NUAK1	2.99686692
6	WNK3	2.99427409
7	DYRK3	2.72274423
8	TLK1	2.56862698
9	EIF2AK3	2.46315776
10	ZAK	2.45548681
11	MAP4K2	2.42187801
12	TSSK6	2.41999836
13	PLK2	2.36186136
14	NEK1	2.18241843
15	FRK	2.13820233
16	MAP2K7	2.07368210
17	MKNK1	2.03312685
18	RPS6KA4	2.02393364
19	BUB1	1.99879427
20	MAP3K4	1.98883373
21	BCKDK	1.96160436
22	VRK2	1.80660663
23	TAF1	1.73936569
24	ADRBK2	1.68569858
25	PDK2	1.62438389
26	KIT	1.60821455
27	STK16	1.54680777
28	MKNK2	1.48584129
29	PLK4	1.44666916
30	TRIM28	1.40138213
31	CDK19	1.35263312
32	NEK9	1.30793843
33	EPHA3	1.24083868
34	GRK1	1.13115973
35	MATK	1.10533258
36	ATR	1.08381457
37	BMPR1B	1.05770973
38	VRK1	0.99681979
39	DAPK2	0.99557414
40	WNK4	0.98785164
41	PBK	0.98337907
42	MAP2K4	0.94639788
43	PASK	0.89705121
44	BRD4	0.89317245
45	PLK3	0.88794556
46	AKT3	0.84291993
47	BLK	0.78237721
48	MAPK13	0.75713908
49	RPS6KA5	0.75252001
50	WEE1	0.69568947
51	TNIK	0.67238963
52	PRKCE	0.65961235
53	CSNK1G1	0.64417438
54	TXK	0.62774923
55	CSNK1G3	0.60655063
56	ERBB3	0.59787272
57	NME1	0.58976362
58	BCR	0.57636782
59	TEC	0.57475444
60	MAP3K12	0.57242540
61	EIF2AK2	0.56902755
62	TAOK3	0.55155354
63	ITK	0.54709849
64	MINK1	0.53728884
65	PINK1	0.52911035
66	STK39	0.50419876
67	SGK2	0.49908521
68	PRKD3	0.49870538
69	MAP2K6	0.48043497
70	AURKB	0.40620545
71	CSNK1A1	0.38846210
72	CSNK1G2	0.37828915
73	BMPR2	0.37671419
74	OXSR1	0.36664207
75	TIE1	0.35142238
76	CSNK1A1L	0.34899109
77	DYRK1A	0.34671655
78	CAMK4	0.31540075
79	MAP3K5	0.31060289
80	PLK1	0.30409220
81	ATM	0.30337240
82	DYRK2	0.29154766
83	TNK2	0.28970904
84	MAP3K6	0.28328816
85	AKT2	0.27336241
86	IGF1R	0.26652537
87	FGFR1	0.24694139
88	BRSK1	0.23804265
89	CSNK2A1	0.22600306
90	TAOK2	0.22237431
91	CDK8	0.21902474
92	DAPK1	0.21634609
93	MAPKAPK5	0.17084122
94	INSRR	0.16990604
95	TYK2	0.16646278
96	IKBKB	0.15861704
97	SGK223	0.15558565
98	SGK494	0.15558565
99	CAMK2A	0.15491505
100	AURKA	0.13910674

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.51044923
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.26167792
3	Proteasome_Homo sapiens_hsa03050	2.79203563
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.68348591
5	Tryptophan metabolism_Homo sapiens_hsa00380	2.66459188
6	RNA polymerase_Homo sapiens_hsa03020	2.55035168
7	Propanoate metabolism_Homo sapiens_hsa00640	2.49951340
8	Butanoate metabolism_Homo sapiens_hsa00650	2.41246008
9	Protein export_Homo sapiens_hsa03060	2.28076443
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.20997731
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.19403793
12	Basal transcription factors_Homo sapiens_hsa03022	2.16250451
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11833809
14	beta-Alanine metabolism_Homo sapiens_hsa00410	1.81089796
15	Fatty acid degradation_Homo sapiens_hsa00071	1.77271401
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.76736674
17	Homologous recombination_Homo sapiens_hsa03440	1.73880284
18	RNA degradation_Homo sapiens_hsa03018	1.70833384
19	Circadian rhythm_Homo sapiens_hsa04710	1.64371734
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60739617
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60494281
22	Mismatch repair_Homo sapiens_hsa03430	1.60179641
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.58625746
24	One carbon pool by folate_Homo sapiens_hsa00670	1.55757136
25	Spliceosome_Homo sapiens_hsa03040	1.53120608
26	Sulfur relay system_Homo sapiens_hsa04122	1.46887573
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43619813
28	Fatty acid elongation_Homo sapiens_hsa00062	1.40987705
29	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.39501784
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.35513489
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.33966384
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.31824412
33	Purine metabolism_Homo sapiens_hsa00230	1.31649364
34	Peroxisome_Homo sapiens_hsa04146	1.24574189
35	Parkinsons disease_Homo sapiens_hsa05012	1.23492544
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.20879179
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19227798
38	Huntingtons disease_Homo sapiens_hsa05016	1.17747912
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14874381
40	Lysine degradation_Homo sapiens_hsa00310	1.14230518
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.11927323
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.11543070
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11154176
44	DNA replication_Homo sapiens_hsa03030	1.08021328
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01879686
46	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.01428117
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00970792
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.00807743
49	Regulation of autophagy_Homo sapiens_hsa04140	0.97724166
50	RNA transport_Homo sapiens_hsa03013	0.97002379
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93703727
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89415250
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87760479
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87270826
55	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.87023603
56	Phototransduction_Homo sapiens_hsa04744	0.78430164
57	Carbon metabolism_Homo sapiens_hsa01200	0.75822346
58	Metabolic pathways_Homo sapiens_hsa01100	0.75066859
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71998158
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71082676
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71064148
62	Olfactory transduction_Homo sapiens_hsa04740	0.70562538
63	Alzheimers disease_Homo sapiens_hsa05010	0.69526276
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.68269369
65	Histidine metabolism_Homo sapiens_hsa00340	0.68186846
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67725636
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67594172
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66114540
69	Arginine biosynthesis_Homo sapiens_hsa00220	0.65598359
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64570283
71	Nicotine addiction_Homo sapiens_hsa05033	0.63611954
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63322832
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.62363324
74	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.62184913
75	Caffeine metabolism_Homo sapiens_hsa00232	0.61077391
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.59603126
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.59172453
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58222461
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.58006802
80	Retinol metabolism_Homo sapiens_hsa00830	0.57033110
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.55660637
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55258597
83	Folate biosynthesis_Homo sapiens_hsa00790	0.54539952
84	Glutathione metabolism_Homo sapiens_hsa00480	0.50422522
85	GABAergic synapse_Homo sapiens_hsa04727	0.50014310
86	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.49573537
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.46952439
88	Taste transduction_Homo sapiens_hsa04742	0.46801109
89	Base excision repair_Homo sapiens_hsa03410	0.46200282
90	ABC transporters_Homo sapiens_hsa02010	0.42218594
91	Morphine addiction_Homo sapiens_hsa05032	0.42186636
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41473988
93	Oocyte meiosis_Homo sapiens_hsa04114	0.37743142
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.37358624
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.36404280
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32517476
97	Ribosome_Homo sapiens_hsa03010	0.30876911
98	Salivary secretion_Homo sapiens_hsa04970	0.30055849
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28374744
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25706994

PPIAP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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