PPIAP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)4.81444110
2regulation of podosome assembly (GO:0071801)4.70564766
3regulation of interleukin-12 biosynthetic process (GO:0045075)4.51396286
4negative regulation of T-helper cell differentiation (GO:0045623)4.40904920
5negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.40904920
6regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.05016903
7positive regulation of interleukin-1 beta secretion (GO:0050718)3.93736352
8negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.86015646
9T cell differentiation involved in immune response (GO:0002292)3.84359258
10alpha-beta T cell differentiation involved in immune response (GO:0002293)3.84359258
11alpha-beta T cell activation involved in immune response (GO:0002287)3.84359258
12defense response to protozoan (GO:0042832)3.75608408
13regulation of interleukin-1 beta secretion (GO:0050706)3.72809812
14fucose catabolic process (GO:0019317)3.70284760
15L-fucose metabolic process (GO:0042354)3.70284760
16L-fucose catabolic process (GO:0042355)3.70284760
17positive regulation of interleukin-1 secretion (GO:0050716)3.67700691
18negative regulation of interleukin-17 production (GO:0032700)3.58905930
19regulation of B cell apoptotic process (GO:0002902)3.56561943
20regulation of MHC class II biosynthetic process (GO:0045346)3.56301516
21immunoglobulin mediated immune response (GO:0016064)3.53013025
22positive regulation of isotype switching (GO:0045830)3.38731502
23positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.35607142
24regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.35607142
25positive regulation of DNA recombination (GO:0045911)3.33842252
26positive regulation of chemokine biosynthetic process (GO:0045080)3.32548995
27regulation of memory T cell differentiation (GO:0043380)3.26012864
28response to protozoan (GO:0001562)3.24060005
29organelle disassembly (GO:1903008)3.23293592
30regulation of vitamin D biosynthetic process (GO:0060556)3.22480705
31regulation of interleukin-1 secretion (GO:0050704)3.21696035
32alpha-beta T cell differentiation (GO:0046632)3.19558721
33regulation of thymocyte apoptotic process (GO:0070243)3.17862727
34regulation of interleukin-6 biosynthetic process (GO:0045408)3.17322821
35negative regulation of alpha-beta T cell differentiation (GO:0046639)3.16014937
36positive regulation of interleukin-12 production (GO:0032735)3.06922200
37modulation of growth of symbiont involved in interaction with host (GO:0044144)3.03360391
38regulation of growth of symbiont in host (GO:0044126)3.03360391
39negative regulation of growth of symbiont in host (GO:0044130)3.03360391
40negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.03360391
41regulation of regulatory T cell differentiation (GO:0045589)3.02288400
42alpha-beta T cell activation (GO:0046631)2.98988562
43ribonucleoprotein complex disassembly (GO:0032988)2.98773716
44tolerance induction (GO:0002507)2.97899421
45B cell mediated immunity (GO:0019724)2.95841791
46tyrosine phosphorylation of STAT protein (GO:0007260)2.95555432
47interferon-gamma production (GO:0032609)2.95114327
48positive regulation of interleukin-1 beta production (GO:0032731)2.93937628
49purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.92405637
50piRNA metabolic process (GO:0034587)2.90540946
51interferon-gamma-mediated signaling pathway (GO:0060333)2.89133121
52negative regulation of thymocyte apoptotic process (GO:0070244)2.86003560
53adenosine metabolic process (GO:0046085)2.84456935
54positive regulation of organelle assembly (GO:1902117)2.84096106
55negative regulation of B cell apoptotic process (GO:0002903)2.83310585
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81194997
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.81194997
58NADH dehydrogenase complex assembly (GO:0010257)2.81194997
59T cell activation involved in immune response (GO:0002286)2.77969076
60negative regulation of mast cell activation (GO:0033004)2.75541747
61protein neddylation (GO:0045116)2.72761956
62CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71945003
63T-helper cell differentiation (GO:0042093)2.71945003
64cytokine production involved in immune response (GO:0002367)2.69499537
65positive regulation of interleukin-1 production (GO:0032732)2.69194289
66regulation of smooth muscle cell apoptotic process (GO:0034391)2.69169811
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69135743
68response to interleukin-15 (GO:0070672)2.69006084
69deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68786037
70antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68167902
71regulation of interleukin-12 production (GO:0032655)2.67481327
72regulation of B cell receptor signaling pathway (GO:0050855)2.67426712
73negative regulation of interleukin-12 production (GO:0032695)2.65635808
74histamine secretion (GO:0001821)2.65612040
75positive regulation of interleukin-10 production (GO:0032733)2.62212615
76negative regulation of alpha-beta T cell activation (GO:0046636)2.62004217
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61964722
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61964722
79DNA deamination (GO:0045006)2.61445984
80regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59762904
81negative regulation of neurological system process (GO:0031645)2.59388913
82negative regulation of metanephros development (GO:0072217)2.59348724
83regulation of isotype switching (GO:0045191)2.58714004
84regulation of germinal center formation (GO:0002634)2.57273365
85cellular response to interleukin-15 (GO:0071350)2.56190116
86regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.54936543
87positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.53837234
88leukocyte aggregation (GO:0070486)2.52147837
89positive regulation of muscle cell apoptotic process (GO:0010661)2.52075070
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51150865
91regulation of interleukin-1 beta production (GO:0032651)2.50890754
92antigen processing and presentation of endogenous antigen (GO:0019883)2.49485852
93protein import into nucleus, translocation (GO:0000060)2.48991711
94production of molecular mediator of immune response (GO:0002440)2.48651864
95regulation of alpha-beta T cell proliferation (GO:0046640)2.48434934
96positive regulation of T cell mediated cytotoxicity (GO:0001916)2.47994841
97regulation of T-helper cell differentiation (GO:0045622)2.47963659
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.47873151
99positive regulation of B cell mediated immunity (GO:0002714)2.47873151
100protein K6-linked ubiquitination (GO:0085020)2.47042051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.42159253
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.45199846
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.64688539
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.41045629
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26501960
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67060085
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65864695
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59002512
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57694718
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.45021674
11VDR_23849224_ChIP-Seq_CD4+_Human2.44658575
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40687698
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.40220763
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31446143
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10913132
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10022404
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04399715
18MYB_26560356_Chip-Seq_TH2_Human2.02831614
19GATA3_26560356_Chip-Seq_TH2_Human1.94508776
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.92366856
21FOXP3_21729870_ChIP-Seq_TREG_Human1.91579789
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.91133128
23ZNF274_21170338_ChIP-Seq_K562_Hela1.89948388
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.88184248
25ELK1_19687146_ChIP-ChIP_HELA_Human1.86444280
26SPI1_23547873_ChIP-Seq_NB4_Human1.83718315
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83713452
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.83397411
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81346404
30VDR_22108803_ChIP-Seq_LS180_Human1.76265013
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75181444
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73415394
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72657208
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72245447
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71464226
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66340242
37RUNX_20019798_ChIP-Seq_JUKART_Human1.65228592
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61477803
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59193735
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54818674
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53747930
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53107540
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51048783
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47512794
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43363561
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.40732297
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40626493
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40068074
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37614777
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36871734
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.36355544
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33665114
53MYB_26560356_Chip-Seq_TH1_Human1.33204793
54MYC_18940864_ChIP-ChIP_HL60_Human1.32257473
55IRF1_19129219_ChIP-ChIP_H3396_Human1.31804292
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30843176
57GATA3_27048872_Chip-Seq_THYMUS_Human1.29337610
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.25020982
59TP53_22573176_ChIP-Seq_HFKS_Human1.19670153
60ER_23166858_ChIP-Seq_MCF-7_Human1.17210499
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15517636
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13843732
63GABP_19822575_ChIP-Seq_HepG2_Human1.12945978
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11986086
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11830975
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.11071259
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09450903
68NCOR_22424771_ChIP-Seq_293T_Human1.09038287
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08573242
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07261222
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06786658
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05650097
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05065298
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04553638
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.04529915
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04121271
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02392055
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02154957
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.00599449
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00599449
81VDR_24787735_ChIP-Seq_THP-1_Human0.99482848
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99067828
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.98582111
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.97697003
85AR_20517297_ChIP-Seq_VCAP_Human0.97524683
86PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97028583
87GATA3_26560356_Chip-Seq_TH1_Human0.96850532
88SOX2_19829295_ChIP-Seq_ESCs_Human0.95689210
89NANOG_19829295_ChIP-Seq_ESCs_Human0.95689210
90P300_19829295_ChIP-Seq_ESCs_Human0.94281027
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93856310
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92681308
93SALL4_22934838_ChIP-ChIP_CD34+_Human0.91718797
94KDM5A_27292631_Chip-Seq_BREAST_Human0.91108929
95CIITA_25753668_ChIP-Seq_RAJI_Human0.91042322
96RUNX1_22412390_ChIP-Seq_EML_Mouse0.91038165
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90109737
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89293026
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89142137
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88227166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.66296672
2MP0001873_stomach_inflammation3.41439860
3MP0005671_abnormal_response_to3.24021158
4MP0002138_abnormal_hepatobiliary_system3.21204946
5MP0003787_abnormal_imprinting2.95073644
6MP0003724_increased_susceptibility_to2.92973943
7MP0002148_abnormal_hypersensitivity_rea2.89337366
8MP0009785_altered_susceptibility_to2.87082292
9MP0000685_abnormal_immune_system2.72966887
10MP0008877_abnormal_DNA_methylation2.71056278
11MP0005387_immune_system_phenotype2.69978470
12MP0001790_abnormal_immune_system2.69978470
13MP0001800_abnormal_humoral_immune2.62774024
14MP0005000_abnormal_immune_tolerance2.57882389
15MP0003436_decreased_susceptibility_to2.39220295
16MP0003195_calcinosis2.38796569
17MP0009333_abnormal_splenocyte_physiolog2.31459558
18MP0002723_abnormal_immune_serum2.07637499
19MP0002420_abnormal_adaptive_immunity1.97368079
20MP0002452_abnormal_antigen_presenting1.97197908
21MP0004782_abnormal_surfactant_physiolog1.96990624
22MP0001819_abnormal_immune_cell1.96530894
23MP0003806_abnormal_nucleotide_metabolis1.93109561
24MP0002419_abnormal_innate_immunity1.92687449
25MP0005025_abnormal_response_to1.85148948
26MP0002405_respiratory_system_inflammati1.83026957
27MP0005075_abnormal_melanosome_morpholog1.81303686
28MP0009764_decreased_sensitivity_to1.77180263
29MP0002166_altered_tumor_susceptibility1.77130181
30MP0006082_CNS_inflammation1.76536161
31MP0000372_irregular_coat_pigmentation1.72599136
32MP0008875_abnormal_xenobiotic_pharmacok1.64862323
33MP0010155_abnormal_intestine_physiology1.56775955
34MP0008872_abnormal_physiological_respon1.54006852
35MP0000716_abnormal_immune_system1.52571885
36MP0001986_abnormal_taste_sensitivity1.45818922
37MP0001348_abnormal_lacrimal_gland1.44694252
38MP0002398_abnormal_bone_marrow1.40744155
39MP0002006_tumorigenesis1.40735963
40MP0003646_muscle_fatigue1.40482180
41MP0005310_abnormal_salivary_gland1.39709069
42MP0000689_abnormal_spleen_morphology1.36716177
43MP0003186_abnormal_redox_activity1.34608823
44MP0003763_abnormal_thymus_physiology1.31945644
45MP0005084_abnormal_gallbladder_morpholo1.27124740
46MP0001845_abnormal_inflammatory_respons1.26742950
47MP0002429_abnormal_blood_cell1.20840950
48MP0000613_abnormal_salivary_gland1.18556725
49MP0002254_reproductive_system_inflammat1.16397231
50MP0001919_abnormal_reproductive_system1.13934087
51MP0002277_abnormal_respiratory_mucosa1.13744160
52MP0002163_abnormal_gland_morphology1.13383158
53MP0001533_abnormal_skeleton_physiology1.12576245
54MP0000703_abnormal_thymus_morphology1.12198438
55MP0001663_abnormal_digestive_system1.11393722
56MP0004484_altered_response_of1.11181576
57MP0002722_abnormal_immune_system1.10443361
58MP0000427_abnormal_hair_cycle1.09832743
59MP0002009_preneoplasia1.07267156
60MP0008469_abnormal_protein_level1.06185440
61MP0001968_abnormal_touch/_nociception1.02226805
62MP0004381_abnormal_hair_follicle1.02121732
63MP0005377_hearing/vestibular/ear_phenot1.01668190
64MP0003878_abnormal_ear_physiology1.01668190
65MP0005645_abnormal_hypothalamus_physiol1.00140637
66MP0002837_dystrophic_cardiac_calcinosis0.96216752
67MP0002693_abnormal_pancreas_physiology0.96092773
68MP0000371_diluted_coat_color0.96042854
69MP0000569_abnormal_digit_pigmentation0.95573082
70MP0005167_abnormal_blood-brain_barrier0.92556552
71MP0002102_abnormal_ear_morphology0.90034151
72MP0003252_abnormal_bile_duct0.87448079
73MP0005464_abnormal_platelet_physiology0.86836571
74MP0002877_abnormal_melanocyte_morpholog0.86588067
75MP0003045_fibrosis0.85403899
76MP0005389_reproductive_system_phenotype0.84537943
77MP0001853_heart_inflammation0.82253985
78MP0002876_abnormal_thyroid_physiology0.80549439
79MP0005551_abnormal_eye_electrophysiolog0.80463314
80MP0005166_decreased_susceptibility_to0.80363869
81MP0005379_endocrine/exocrine_gland_phen0.79842392
82MP0003950_abnormal_plasma_membrane0.78499812
83MP0010094_abnormal_chromosome_stability0.76672585
84MP0000015_abnormal_ear_pigmentation0.75086165
85MP0004147_increased_porphyrin_level0.73862493
86MP0009765_abnormal_xenobiotic_induced0.73494666
87MP0001765_abnormal_ion_homeostasis0.73019960
88MP0002638_abnormal_pupillary_reflex0.71812644
89MP0003075_altered_response_to0.71313189
90MP0004808_abnormal_hematopoietic_stem0.70299108
91MP0002396_abnormal_hematopoietic_system0.69248876
92MP0005174_abnormal_tail_pigmentation0.67892737
93MP0003786_premature_aging0.67485250
94MP0004142_abnormal_muscle_tone0.67185462
95MP0000343_altered_response_to0.66729643
96MP0006036_abnormal_mitochondrial_physio0.66448801
97MP0004019_abnormal_vitamin_homeostasis0.66448199
98MP0002019_abnormal_tumor_incidence0.65239582
99MP0005319_abnormal_enzyme/_coenzyme0.63369083
100MP0003866_abnormal_defecation0.63223381

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.83640092
2Elevated erythrocyte sedimentation rate (HP:0003565)4.63710706
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.88394252
4Congenital stationary night blindness (HP:0007642)3.62594438
5Retrobulbar optic neuritis (HP:0100654)3.41259242
6Optic neuritis (HP:0100653)3.41259242
7Abnormal rod and cone electroretinograms (HP:0008323)3.36975331
8Type II lissencephaly (HP:0007260)3.23500426
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.11111676
10Acute necrotizing encephalopathy (HP:0006965)3.02865586
11Myositis (HP:0100614)3.02157973
12Orchitis (HP:0100796)2.98065031
13Increased CSF lactate (HP:0002490)2.92077732
14Autoimmune hemolytic anemia (HP:0001890)2.86321084
15Mitochondrial inheritance (HP:0001427)2.81014027
16IgG deficiency (HP:0004315)2.79478250
17Progressive macrocephaly (HP:0004481)2.77533141
18Pancreatic cysts (HP:0001737)2.70876333
19Acute encephalopathy (HP:0006846)2.69721921
203-Methylglutaconic aciduria (HP:0003535)2.69717647
21Keratoconjunctivitis (HP:0001096)2.64050284
22Lipid accumulation in hepatocytes (HP:0006561)2.62430026
23Increased hepatocellular lipid droplets (HP:0006565)2.61080436
24Abnormality of the prostate (HP:0008775)2.60663564
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.58463453
26Hypothermia (HP:0002045)2.58014265
27Increased serum pyruvate (HP:0003542)2.57881567
28Decreased central vision (HP:0007663)2.55774263
29Pulmonary infiltrates (HP:0002113)2.54324373
30Constricted visual fields (HP:0001133)2.48126307
31Abnormality of the pons (HP:0007361)2.46831613
32Hypoplasia of the pons (HP:0012110)2.44919565
33Increased IgM level (HP:0003496)2.42744110
34Meningitis (HP:0001287)2.42274547
35Recurrent fungal infections (HP:0002841)2.41703636
36Abnormality of T cell physiology (HP:0011840)2.41683666
37Exertional dyspnea (HP:0002875)2.41116494
38Abnormal mitochondria in muscle tissue (HP:0008316)2.41058457
39Asplenia (HP:0001746)2.39593710
40Hemoptysis (HP:0002105)2.35470817
41Panhypogammaglobulinemia (HP:0003139)2.35284395
42Chronic mucocutaneous candidiasis (HP:0002728)2.34500472
43Recurrent cutaneous fungal infections (HP:0011370)2.34500472
44Encephalitis (HP:0002383)2.30768339
45Abnormality of B cell number (HP:0010975)2.29456752
46Vasculitis (HP:0002633)2.28983867
47Hypoproteinemia (HP:0003075)2.28460415
48Keratoconjunctivitis sicca (HP:0001097)2.27547466
49Pancreatic fibrosis (HP:0100732)2.25457127
50Increased serum lactate (HP:0002151)2.22971759
51Abnormality of T cells (HP:0002843)2.18836749
52Attenuation of retinal blood vessels (HP:0007843)2.17983396
53Keratitis (HP:0000491)2.16195820
54Lissencephaly (HP:0001339)2.10797908
55Hypomagnesemia (HP:0002917)2.10042648
56Hypoalbuminemia (HP:0003073)2.07005550
57Abnormal albumin level (HP:0012116)2.07005550
58Recurrent abscess formation (HP:0002722)2.04685974
59Hepatocellular necrosis (HP:0001404)2.03127567
60Abnormality of renal resorption (HP:0011038)2.02835015
61Stomach cancer (HP:0012126)2.02747138
62Polydipsia (HP:0001959)2.02167580
63Abnormal drinking behavior (HP:0030082)2.02167580
64Respiratory difficulties (HP:0002880)2.01754067
65Renal Fanconi syndrome (HP:0001994)1.98622341
66Recurrent bacterial skin infections (HP:0005406)1.98233728
67Parakeratosis (HP:0001036)1.97454171
68Mediastinal lymphadenopathy (HP:0100721)1.97064632
69Abnormality of glycolysis (HP:0004366)1.96342768
70Anorexia (HP:0002039)1.95785311
71Porencephaly (HP:0002132)1.95269687
72Microretrognathia (HP:0000308)1.93615484
73Alveolar cell carcinoma (HP:0006519)1.91146023
74Optic disc pallor (HP:0000543)1.90235303
75Polyuria (HP:0000103)1.88775580
76Type 2 muscle fiber atrophy (HP:0003554)1.87854377
77Abnormality of renal excretion (HP:0011036)1.87565367
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86700972
79Ketoacidosis (HP:0001993)1.86322235
80Autoimmune thrombocytopenia (HP:0001973)1.85656515
81Gastrointestinal infarctions (HP:0005244)1.85315701
82Abnormality of T cell number (HP:0011839)1.85219167
83Chest pain (HP:0100749)1.85165445
84Obstructive lung disease (HP:0006536)1.85111322
85Chronic obstructive pulmonary disease (HP:0006510)1.85111322
86Prostate neoplasm (HP:0100787)1.81511939
87Hepatic necrosis (HP:0002605)1.81453260
88Gangrene (HP:0100758)1.81298526
89Increased intramyocellular lipid droplets (HP:0012240)1.80292420
90Abnormality of alanine metabolism (HP:0010916)1.79523291
91Hyperalaninemia (HP:0003348)1.79523291
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79523291
93Abnormality of midbrain morphology (HP:0002418)1.78506790
94Molar tooth sign on MRI (HP:0002419)1.78506790
95Urticaria (HP:0001025)1.77574236
96Abnormality of the pleura (HP:0002103)1.77353228
97Tubular atrophy (HP:0000092)1.74201059
98Hyperphosphatemia (HP:0002905)1.70948997
99Pachygyria (HP:0001302)1.70782465
100Neoplasm of the tracheobronchial system (HP:0100552)1.70619305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.11076856
2MST44.05866272
3CDK193.60577664
4EIF2AK32.95020111
5WNK42.62756866
6MAP3K102.54063329
7EIF2AK12.50778740
8FRK2.42623784
9GRK12.28915105
10MAP3K122.24109435
11MAP4K12.07327635
12TEC2.06331790
13IRAK42.04964912
14ADRBK22.00212000
15STK391.95962638
16OXSR11.83166949
17BMPR21.73479504
18SIK31.71744131
19IKBKB1.70219807
20TRIM281.67299710
21VRK21.64103533
22ITK1.55620614
23CDK81.52442770
24STK101.47121103
25FLT31.33688686
26TSSK61.31879348
27JAK31.22710337
28NME11.19530897
29BTK1.19417496
30TAOK31.18568327
31TLK11.17915313
32PINK11.16576826
33TIE11.08929750
34PDK21.01958598
35ZAK1.01849088
36NUAK11.00184773
37CAMKK20.99139243
38KIT0.98241946
39NEK10.97783905
40BUB10.95476381
41EIF2AK20.92933407
42ADRBK10.92554723
43SYK0.92513329
44LYN0.89514796
45WNK30.88178000
46GRK60.88124693
47BRD40.87264846
48PLK20.85568365
49PRKCI0.84693958
50MAP2K60.84546974
51PBK0.83492329
52IRAK10.77922423
53MAP3K50.75437014
54MAP3K140.74679176
55INSRR0.74137062
56MAP2K70.73204502
57RIPK40.73087733
58BMPR1B0.71860149
59LCK0.67593739
60CSK0.66404612
61IKBKE0.65478819
62WNK10.64543659
63BCKDK0.64489623
64ALK0.63203921
65PLK30.61420558
66HCK0.60734066
67LRRK20.59339841
68CSF1R0.58759818
69PRKCQ0.58720184
70ILK0.58171804
71PTK2B0.57528775
72TAF10.56795877
73BCR0.54078859
74DAPK20.53939963
75TNK20.48554182
76MAP3K110.47709613
77JAK20.45899106
78DAPK10.44588184
79IGF1R0.44429426
80ZAP700.41951555
81VRK10.41349401
82MAP2K30.40254345
83ABL10.40253335
84CCNB10.38077392
85PAK30.37898080
86SIK20.35233533
87CDK60.35032917
88TESK20.34697130
89CHUK0.34418885
90CDC70.32699620
91PIK3CG0.31502183
92GRK70.31353958
93PDK10.30340770
94ABL20.29658883
95TYK20.29081740
96MKNK20.28785712
97MYLK0.28714246
98DYRK20.28374393
99MAP4K20.28183831
100IRAK20.27881418

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.10280405
2Proteasome_Homo sapiens_hsa030504.00733930
3Asthma_Homo sapiens_hsa053103.46679864
4Autoimmune thyroid disease_Homo sapiens_hsa053203.20142383
5Type I diabetes mellitus_Homo sapiens_hsa049403.15491060
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.07353299
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.03468380
8Graft-versus-host disease_Homo sapiens_hsa053322.98865950
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62551139
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.09694975
11Hematopoietic cell lineage_Homo sapiens_hsa046402.09655201
12Primary immunodeficiency_Homo sapiens_hsa053402.03316048
13Leishmaniasis_Homo sapiens_hsa051402.02074439
14Rheumatoid arthritis_Homo sapiens_hsa053231.98500228
15Protein export_Homo sapiens_hsa030601.93515281
16One carbon pool by folate_Homo sapiens_hsa006701.70565704
17Antigen processing and presentation_Homo sapiens_hsa046121.60080619
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58887137
19T cell receptor signaling pathway_Homo sapiens_hsa046601.58657990
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51628278
21Regulation of autophagy_Homo sapiens_hsa041401.51502038
22Staphylococcus aureus infection_Homo sapiens_hsa051501.50666977
23Oxidative phosphorylation_Homo sapiens_hsa001901.48963586
24Measles_Homo sapiens_hsa051621.35750671
25Basal transcription factors_Homo sapiens_hsa030221.32053553
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29579968
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26575848
28RNA degradation_Homo sapiens_hsa030181.25414029
29Viral myocarditis_Homo sapiens_hsa054161.22712870
30Parkinsons disease_Homo sapiens_hsa050121.21632506
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18365470
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18282884
33Phototransduction_Homo sapiens_hsa047441.18270943
34Tuberculosis_Homo sapiens_hsa051521.17269777
35Homologous recombination_Homo sapiens_hsa034401.16606630
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14123711
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.12674006
38Legionellosis_Homo sapiens_hsa051341.10041517
39Malaria_Homo sapiens_hsa051441.09137584
40RNA polymerase_Homo sapiens_hsa030201.06570762
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05563967
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02656958
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.92731702
44Herpes simplex infection_Homo sapiens_hsa051680.92657214
45Influenza A_Homo sapiens_hsa051640.92033558
46Ribosome_Homo sapiens_hsa030100.91642226
47Osteoclast differentiation_Homo sapiens_hsa043800.90183599
48RNA transport_Homo sapiens_hsa030130.89103833
49African trypanosomiasis_Homo sapiens_hsa051430.88568254
50Linoleic acid metabolism_Homo sapiens_hsa005910.88253448
51Nitrogen metabolism_Homo sapiens_hsa009100.86323985
52B cell receptor signaling pathway_Homo sapiens_hsa046620.85150378
53Nucleotide excision repair_Homo sapiens_hsa034200.84611672
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84336553
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77182375
56Phagosome_Homo sapiens_hsa041450.76235701
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75349395
58Peroxisome_Homo sapiens_hsa041460.73549595
59Ether lipid metabolism_Homo sapiens_hsa005650.70308484
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70042664
61Pyrimidine metabolism_Homo sapiens_hsa002400.69784283
62Epstein-Barr virus infection_Homo sapiens_hsa051690.68935055
63Systemic lupus erythematosus_Homo sapiens_hsa053220.65101242
64Toxoplasmosis_Homo sapiens_hsa051450.63630372
65Butanoate metabolism_Homo sapiens_hsa006500.63374204
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61879283
67TNF signaling pathway_Homo sapiens_hsa046680.58245450
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58079254
69Arachidonic acid metabolism_Homo sapiens_hsa005900.57596552
70Propanoate metabolism_Homo sapiens_hsa006400.57306792
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56928290
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56269322
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55458024
74Collecting duct acid secretion_Homo sapiens_hsa049660.53858868
75Huntingtons disease_Homo sapiens_hsa050160.53376535
76Fanconi anemia pathway_Homo sapiens_hsa034600.52162534
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49384523
78Purine metabolism_Homo sapiens_hsa002300.48292023
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45840386
80Salmonella infection_Homo sapiens_hsa051320.44911853
81Sulfur metabolism_Homo sapiens_hsa009200.44727804
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43619283
83Dorso-ventral axis formation_Homo sapiens_hsa043200.42192417
84Alzheimers disease_Homo sapiens_hsa050100.42051830
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39106318
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37244147
87Mismatch repair_Homo sapiens_hsa034300.37110013
88Spliceosome_Homo sapiens_hsa030400.33661507
89p53 signaling pathway_Homo sapiens_hsa041150.33136686
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31683994
91Non-homologous end-joining_Homo sapiens_hsa034500.30905156
92Chemokine signaling pathway_Homo sapiens_hsa040620.30255725
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28673544
94Caffeine metabolism_Homo sapiens_hsa002320.25711552
95Viral carcinogenesis_Homo sapiens_hsa052030.23731592
96Steroid biosynthesis_Homo sapiens_hsa001000.22392534
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.19277297
98Olfactory transduction_Homo sapiens_hsa047400.19196516
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18314094
100Folate biosynthesis_Homo sapiens_hsa007900.16638690

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