PPIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.31215920
2protein heterotrimerization (GO:0070208)4.83997764
3chondrocyte proliferation (GO:0035988)4.83209272
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.18949593
5bone trabecula formation (GO:0060346)4.17439804
6protein retention in ER lumen (GO:0006621)4.08133728
7keratan sulfate catabolic process (GO:0042340)4.07380921
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.04133855
9endodermal cell differentiation (GO:0035987)4.03289150
10proteasome assembly (GO:0043248)3.96579872
11protein maturation by protein folding (GO:0022417)3.93302842
12endothelial cell morphogenesis (GO:0001886)3.88933653
13collagen metabolic process (GO:0032963)3.85238553
14basement membrane organization (GO:0071711)3.77176510
15collagen catabolic process (GO:0030574)3.76090903
16desmosome organization (GO:0002934)3.73122970
17peptidyl-proline hydroxylation (GO:0019511)3.72298835
18regulation of cardioblast differentiation (GO:0051890)3.66768890
19negative regulation of chondrocyte differentiation (GO:0032331)3.66222579
20chondrocyte development (GO:0002063)3.60289878
21notochord development (GO:0030903)3.59056795
22regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.57771879
23multicellular organismal macromolecule metabolic process (GO:0044259)3.55549056
24sequestering of extracellular ligand from receptor (GO:0035581)3.55409722
25multicellular organismal catabolic process (GO:0044243)3.54916787
26lymph vessel development (GO:0001945)3.50250831
27multicellular organismal metabolic process (GO:0044236)3.47642718
28extracellular matrix disassembly (GO:0022617)3.38428048
29embryonic skeletal joint morphogenesis (GO:0060272)3.36870456
30skin morphogenesis (GO:0043589)3.35402321
31positive regulation of epithelial to mesenchymal transition (GO:0010718)3.30678388
32protein hydroxylation (GO:0018126)3.29051448
33cell adhesion mediated by integrin (GO:0033627)3.22626775
34vascular endothelial growth factor signaling pathway (GO:0038084)3.19522728
35wound healing, spreading of epidermal cells (GO:0035313)3.15450018
36negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.12668654
37negative regulation of cartilage development (GO:0061037)3.12184408
38type B pancreatic cell proliferation (GO:0044342)3.11776585
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.11415192
40axon extension involved in axon guidance (GO:0048846)3.11415192
41ventricular cardiac muscle cell development (GO:0055015)3.10994412
42positive regulation of endothelial cell apoptotic process (GO:2000353)3.07811424
434-hydroxyproline metabolic process (GO:0019471)3.05342429
44blood vessel maturation (GO:0001955)3.03714778
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02063944
46cell proliferation involved in kidney development (GO:0072111)3.00541347
47membrane raft organization (GO:0031579)3.00253656
48cell migration involved in heart development (GO:0060973)2.99959255
49Golgi transport vesicle coating (GO:0048200)2.98618766
50COPI coating of Golgi vesicle (GO:0048205)2.98618766
51retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96152458
52nucleotide-sugar biosynthetic process (GO:0009226)2.94834788
53hippo signaling (GO:0035329)2.94272245
54fibril organization (GO:0097435)2.93716210
55outer ear morphogenesis (GO:0042473)2.93674660
56cell proliferation involved in metanephros development (GO:0072203)2.90751403
57positive regulation of extracellular matrix organization (GO:1903055)2.90447668
58paraxial mesoderm development (GO:0048339)2.89821822
59mesodermal cell differentiation (GO:0048333)2.89790953
60regulation of integrin-mediated signaling pathway (GO:2001044)2.89265523
61extracellular fibril organization (GO:0043206)2.84872940
62regulation of SMAD protein import into nucleus (GO:0060390)2.84371304
63positive regulation of cartilage development (GO:0061036)2.84349016
64regulation of transforming growth factor beta2 production (GO:0032909)2.83822064
65glomerular basement membrane development (GO:0032836)2.82668577
66mesenchymal-epithelial cell signaling (GO:0060638)2.81719327
67dermatan sulfate biosynthetic process (GO:0030208)2.79077196
68cartilage condensation (GO:0001502)2.78601356
69cell aggregation (GO:0098743)2.78601356
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76123855
71regulation of metalloenzyme activity (GO:0048552)2.75925635
72membrane budding (GO:0006900)2.74644027
73extracellular matrix organization (GO:0030198)2.74522077
74regulation of heart morphogenesis (GO:2000826)2.73722554
75extracellular structure organization (GO:0043062)2.73474864
76endocardial cushion development (GO:0003197)2.73051697
77lymphangiogenesis (GO:0001946)2.73005649
78endothelial tube morphogenesis (GO:0061154)2.71330972
79morphogenesis of an endothelium (GO:0003159)2.71330972
80glomerular filtration (GO:0003094)2.68533384
81COPII vesicle coating (GO:0048208)2.67426397
82metanephric mesenchyme development (GO:0072075)2.66977309
83atrioventricular valve morphogenesis (GO:0003181)2.66889694
84negative regulation of protein localization to cell surface (GO:2000009)2.66282759
85renal filtration (GO:0097205)2.65955560
86mesenchymal cell proliferation (GO:0010463)2.65465335
87mesenchyme morphogenesis (GO:0072132)2.65351901
88positive regulation of actin filament depolymerization (GO:0030836)2.64663173
89ribosomal small subunit assembly (GO:0000028)2.64578775
90positive regulation of stem cell differentiation (GO:2000738)2.64527372
91exocrine pancreas development (GO:0031017)2.63592835
92substrate-dependent cell migration (GO:0006929)2.62592043
93regulation of cartilage development (GO:0061035)2.61600755
94organ formation (GO:0048645)2.60688005
95cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.59694108
96regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58401252
97substrate adhesion-dependent cell spreading (GO:0034446)2.58278097
98epithelial to mesenchymal transition (GO:0001837)2.56703980
99mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.56516880
100gap junction assembly (GO:0016264)2.56435825
101regulation of chondrocyte differentiation (GO:0032330)2.55593528
102epithelial cell-cell adhesion (GO:0090136)2.54797310
103replacement ossification (GO:0036075)2.54606008
104endochondral ossification (GO:0001958)2.54606008
105galactose metabolic process (GO:0006012)2.54077196
106negative regulation of nitric-oxide synthase activity (GO:0051001)2.53159512
107polarized epithelial cell differentiation (GO:0030859)2.52451254
108kidney mesenchyme development (GO:0072074)2.52064496
109dermatan sulfate metabolic process (GO:0030205)2.51856278
110endocardial cushion morphogenesis (GO:0003203)2.51738414
111muscle cell migration (GO:0014812)2.50879668
112wound healing, spreading of cells (GO:0044319)2.49801807
113hemidesmosome assembly (GO:0031581)2.49505537
114regulation of endothelial cell differentiation (GO:0045601)2.49485302
115embryonic cranial skeleton morphogenesis (GO:0048701)2.48471136
116craniofacial suture morphogenesis (GO:0097094)2.47483007
117UDP-N-acetylglucosamine metabolic process (GO:0006047)2.45380024
118middle ear morphogenesis (GO:0042474)2.44978658
119G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.44843125
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44589183
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44439855
122cellular response to vitamin D (GO:0071305)2.44262554
123regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.42513452
124heart trabecula formation (GO:0060347)2.41308495
125protein localization to cell surface (GO:0034394)2.41184656
126regulation of cellular amino acid metabolic process (GO:0006521)2.41036489
127cellular response to vitamin (GO:0071295)2.40330310
128tricarboxylic acid cycle (GO:0006099)2.37829691
129negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.30678371
130organ induction (GO:0001759)2.29946939
131negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.28909945
132positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.28890906
133extracellular negative regulation of signal transduction (GO:1900116)2.26427846
134extracellular regulation of signal transduction (GO:1900115)2.26427846
135negative regulation of keratinocyte proliferation (GO:0010839)2.26139884
136actin filament depolymerization (GO:0030042)2.24685684
137fibrinolysis (GO:0042730)2.18585871
138trabecula formation (GO:0060343)2.17686076
139response to redox state (GO:0051775)2.17334257
140negative regulation of stem cell proliferation (GO:2000647)2.17096071
141nucleobase-containing small molecule interconversion (GO:0015949)2.16571036
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.16536302
143galactose catabolic process (GO:0019388)2.13921029
144barbed-end actin filament capping (GO:0051016)2.11811002
145NADH metabolic process (GO:0006734)2.11642070
146mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.09038664
147sarcomere organization (GO:0045214)2.08381231
148negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.08107543
149dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.07413953
150positive regulation of focal adhesion assembly (GO:0051894)2.06437283
151positive regulation of cell junction assembly (GO:1901890)2.06437283
152positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.05261841
153endocrine hormone secretion (GO:0060986)2.04599558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.99108063
2* TRIM28_21343339_ChIP-Seq_HEK293_Human5.85954024
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.57508391
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.20097224
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.73508826
6CLOCK_20551151_ChIP-Seq_293T_Human3.03496266
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.92082896
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.86397299
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.76137406
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.68674447
11E2F7_22180533_ChIP-Seq_HELA_Human2.54274931
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.51921636
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.51649910
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46020358
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.39298692
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31079180
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30485046
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.24961344
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.22590131
20AR_21909140_ChIP-Seq_LNCAP_Human2.16929334
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.16271627
22ZNF263_19887448_ChIP-Seq_K562_Human2.15965391
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.13439923
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11878834
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08587678
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06584906
27BRD4_25478319_ChIP-Seq_HGPS_Human2.06189404
28* CJUN_26792858_Chip-Seq_BT549_Human2.00650073
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97288694
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87193110
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87193110
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84236304
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80769972
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.74244797
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.73586134
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.73327450
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67713141
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62550462
39NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62439371
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61336527
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57117360
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.55299995
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.54126919
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52935940
45CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50950708
46EOMES_21245162_ChIP-Seq_HESCs_Human1.50356283
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.47734816
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45995925
49* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44224908
50ELK1_19687146_ChIP-ChIP_HELA_Human1.41514028
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41359375
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41244066
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.39749829
54* SOX2_20726797_ChIP-Seq_SW620_Human1.38205888
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35318518
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.35067507
57MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34564454
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34413017
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34197583
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33888318
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33828937
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33792741
63* GATA3_24758297_ChIP-Seq_MCF-7_Human1.33764186
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32354990
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30961720
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28935826
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27372181
68* ATF3_27146783_Chip-Seq_COLON_Human1.27284779
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26166176
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26071805
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23160911
72* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22204476
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21954145
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21717768
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20593748
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20352995
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19160772
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19160772
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19084518
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18675231
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17090937
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.16524062
83GATA4_25053715_ChIP-Seq_YYC3_Human1.16141230
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15837895
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.14231532
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13160557
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.13057332
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11973879
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11804800
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11694141
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10483343
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10014606
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09378095
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09173169
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.08567796
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.07584643
97ELF5_23300383_ChIP-Seq_T47D_Human1.06398067
98* GATA6_25053715_ChIP-Seq_YYC3_Human1.06223946
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05643798
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05302541
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04990084
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.04333588
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04262207
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04249006
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04249006
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04249006
107LXR_22158963_ChIP-Seq_LIVER_Mouse1.04160005
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.03933179
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.03933179
110GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01749374
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01057572
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00979074
113DCP1A_22483619_ChIP-Seq_HELA_Human1.00208918
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98815149
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98646644
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98544495
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.96076219
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.95864363
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94440016
120CDX2_20551321_ChIP-Seq_CACO-2_Human0.94306049
121TP53_22127205_ChIP-Seq_IMR90_Human0.93714635
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93274895
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92730630
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92527083
125CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92089394
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91228204
127ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90971179
128XRN2_22483619_ChIP-Seq_HELA_Human0.90942512
129* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90206105
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89540110
131TP53_18474530_ChIP-ChIP_U2OS_Human0.89382762
132SA1_22415368_ChIP-Seq_MEFs_Mouse0.88353528
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87095275
134RACK7_27058665_Chip-Seq_MCF-7_Human0.86625039
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86026194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.16310429
2MP0005503_abnormal_tendon_morphology4.79856078
3MP0005275_abnormal_skin_tensile4.04486742
4MP0004272_abnormal_basement_membrane3.41043940
5MP0003950_abnormal_plasma_membrane3.28763967
6MP0003705_abnormal_hypodermis_morpholog3.16485856
7MP0003279_aneurysm3.04571494
8MP0006054_spinal_hemorrhage2.96485105
9MP0001958_emphysema2.66695075
10MP0010368_abnormal_lymphatic_system2.63918593
11MP0010030_abnormal_orbit_morphology2.24729460
12MP0001879_abnormal_lymphatic_vessel2.21208811
13MP0005508_abnormal_skeleton_morphology2.10069257
14MP0009250_abnormal_appendicular_skeleto2.07308726
15MP0009384_cardiac_valve_regurgitation2.03420041
16MP0009780_abnormal_chondrocyte_physiolo2.00102612
17MP0000751_myopathy1.97584092
18MP0002282_abnormal_trachea_morphology1.92887950
19MP0003566_abnormal_cell_adhesion1.84237160
20MP0005023_abnormal_wound_healing1.76687448
21MP0001542_abnormal_bone_strength1.73860325
22MP0005408_hypopigmentation1.68397511
23MP0005623_abnormal_meninges_morphology1.68240999
24MP0004134_abnormal_chest_morphology1.66464512
25MP0003191_abnormal_cellular_cholesterol1.65091434
26MP0010352_gastrointestinal_tract_polyps1.59908973
27MP0000163_abnormal_cartilage_morphology1.59537161
28MP0004233_abnormal_muscle_weight1.55160964
29MP0003385_abnormal_body_wall1.53920545
30MP0002060_abnormal_skin_morphology1.53847927
31MP0005330_cardiomyopathy1.50761280
32MP0010234_abnormal_vibrissa_follicle1.49871458
33MP0003941_abnormal_skin_development1.47675377
34MP0003186_abnormal_redox_activity1.46811517
35MP0002896_abnormal_bone_mineralization1.45080816
36MP0000767_abnormal_smooth_muscle1.44806790
37MP0002108_abnormal_muscle_morphology1.42527532
38MP0003806_abnormal_nucleotide_metabolis1.40976060
39MP0005360_urolithiasis1.40940578
40MP0002115_abnormal_skeleton_extremities1.40780419
41MP0003942_abnormal_urinary_system1.39975306
42MP0002933_joint_inflammation1.39792449
43MP0003123_paternal_imprinting1.39116540
44MP0009053_abnormal_anal_canal1.35709696
45MP0002295_abnormal_pulmonary_circulatio1.35083401
46MP0002113_abnormal_skeleton_development1.29903462
47MP0000372_irregular_coat_pigmentation1.29810667
48MP0000733_abnormal_muscle_development1.27862682
49MP0005390_skeleton_phenotype1.25909116
50MP0009840_abnormal_foam_cell1.23642277
51MP0002932_abnormal_joint_morphology1.23011906
52MP0005257_abnormal_intraocular_pressure1.22933786
53MP0000762_abnormal_tongue_morphology1.22184748
54MP0000049_abnormal_middle_ear1.21377460
55MP0005197_abnormal_uvea_morphology1.21180013
56MP0002796_impaired_skin_barrier1.19331343
57MP0000462_abnormal_digestive_system1.18042579
58MP0000537_abnormal_urethra_morphology1.13953661
59MP0005165_increased_susceptibility_to1.13834959
60MP0000534_abnormal_ureter_morphology1.13678139
61MP0003091_abnormal_cell_migration1.12568743
62MP0000516_abnormal_urinary_system1.10238174
63MP0005367_renal/urinary_system_phenotyp1.10238174
64MP0003115_abnormal_respiratory_system1.09555641
65MP0004084_abnormal_cardiac_muscle1.09213334
66MP0001243_abnormal_dermal_layer1.07401009
67MP0002249_abnormal_larynx_morphology1.06874301
68MP0002109_abnormal_limb_morphology1.06479005
69MP0003935_abnormal_craniofacial_develop1.04233023
70MP0001666_abnormal_nutrient_absorption1.04205792
71MP0003755_abnormal_palate_morphology1.02180028
72MP0003122_maternal_imprinting1.01830660
73MP0002089_abnormal_postnatal_growth/wei1.00247124
74MP0000432_abnormal_head_morphology0.99502975
75MP0005501_abnormal_skin_physiology0.97585049
76MP0000750_abnormal_muscle_regeneration0.95143984
77MP0002128_abnormal_blood_circulation0.94922318
78MP0001299_abnormal_eye_distance/0.93224297
79MP0003828_pulmonary_edema0.92996634
80MP0002925_abnormal_cardiovascular_devel0.92201219
81MP0001614_abnormal_blood_vessel0.91882213
82MP0008007_abnormal_cellular_replicative0.91502420
83MP0000467_abnormal_esophagus_morphology0.91105192
84MP0004808_abnormal_hematopoietic_stem0.90694186
85MP0000343_altered_response_to0.90368018
86MP0004036_abnormal_muscle_relaxation0.90099657
87MP0002254_reproductive_system_inflammat0.89845229
88MP0003937_abnormal_limbs/digits/tail_de0.89699887
89MP0009697_abnormal_copulation0.89690985
90MP0000428_abnormal_craniofacial_morphol0.89539303
91MP0003795_abnormal_bone_structure0.89316631
92MP0002972_abnormal_cardiac_muscle0.88376627
93MP0002938_white_spotting0.87968164
94MP0002116_abnormal_craniofacial_bone0.87439340
95MP0009379_abnormal_foot_pigmentation0.87080676
96MP0004197_abnormal_fetal_growth/weight/0.86833425
97MP0010386_abnormal_urinary_bladder0.86797560
98MP0002111_abnormal_tail_morphology0.86057273
99MP0001915_intracranial_hemorrhage0.85777883
100MP0001175_abnormal_lung_morphology0.83246451
101MP0005084_abnormal_gallbladder_morpholo0.83207735
102MP0006138_congestive_heart_failure0.82973753
103MP0003283_abnormal_digestive_organ0.81848131
104MP0003567_abnormal_fetal_cardiomyocyte0.80126415
105MP0002269_muscular_atrophy0.79968970
106MP0000759_abnormal_skeletal_muscle0.79462276
107MP0010771_integument_phenotype0.79216388
108MP0002233_abnormal_nose_morphology0.78400383
109MP0001533_abnormal_skeleton_physiology0.77997214
110MP0000538_abnormal_urinary_bladder0.77398599
111MP0002998_abnormal_bone_remodeling0.77285326
112MP0003868_abnormal_feces_composition0.77190802
113MP0005595_abnormal_vascular_smooth0.76606948
114MP0005193_abnormal_anterior_eye0.75959988
115MP0005164_abnormal_response_to0.75949433
116MP0002877_abnormal_melanocyte_morpholog0.74851597
117MP0005220_abnormal_exocrine_pancreas0.72695170
118MP0004087_abnormal_muscle_fiber0.72475258
119MP0005171_absent_coat_pigmentation0.70734104
120MP0002114_abnormal_axial_skeleton0.69866527
121MP0001270_distended_abdomen0.69631473
122MP0001661_extended_life_span0.69474417
123MP0003984_embryonic_growth_retardation0.68866959
124MP0002086_abnormal_extraembryonic_tissu0.68545356
125MP0005365_abnormal_bile_salt0.68419080
126MP0002139_abnormal_hepatobiliary_system0.68237231
127MP0010630_abnormal_cardiac_muscle0.67710173
128MP0005620_abnormal_muscle_contractility0.67604723
129MP0005085_abnormal_gallbladder_physiolo0.67576244
130MP0002088_abnormal_embryonic_growth/wei0.67471879
131MP0005076_abnormal_cell_differentiation0.67044022
132MP0002133_abnormal_respiratory_system0.66439698
133MP0005388_respiratory_system_phenotype0.66439698
134MP0000749_muscle_degeneration0.63873717
135MP0000266_abnormal_heart_morphology0.63524398
136MP0008775_abnormal_heart_ventricle0.63515604
137MP0002168_other_aberrant_phenotype0.63386190
138MP0003121_genomic_imprinting0.62930325
139MP0003195_calcinosis0.62909540
140MP0000627_abnormal_mammary_gland0.62021521
141MP0000747_muscle_weakness0.60764954
142MP0000013_abnormal_adipose_tissue0.60455208
143MP0001881_abnormal_mammary_gland0.60341428
144MP0000579_abnormal_nail_morphology0.59015508
145MP0004264_abnormal_extraembryonic_tissu0.57961791
146MP0005332_abnormal_amino_acid0.57577997

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.82148736
2Premature rupture of membranes (HP:0001788)5.55520935
3Neonatal short-limb short stature (HP:0008921)4.14729699
4Epiphyseal dysplasia (HP:0002656)3.98868475
5Aortic dissection (HP:0002647)3.83632100
6Ankle contracture (HP:0006466)3.80751856
7Cervical subluxation (HP:0003308)3.80072056
8Atrophic scars (HP:0001075)3.69147285
9Soft skin (HP:0000977)3.63278234
10Right ventricular cardiomyopathy (HP:0011663)3.46035483
11Aortic aneurysm (HP:0004942)3.40658958
12Abnormality of dentin (HP:0010299)3.40368048
13Cupped ribs (HP:0000887)3.31867198
14Shallow orbits (HP:0000586)3.27466078
15Broad metatarsal (HP:0001783)3.26423609
16Vitreoretinal degeneration (HP:0000655)3.22446370
17Irregular epiphyses (HP:0010582)3.17079104
18Hypoplastic ischia (HP:0003175)3.15844824
19Wormian bones (HP:0002645)3.09659716
20Follicular hyperkeratosis (HP:0007502)3.03924716
21Cardiovascular calcification (HP:0011915)2.96248913
22Biconcave vertebral bodies (HP:0004586)2.95703450
23Blue sclerae (HP:0000592)2.95547303
24Spinal rigidity (HP:0003306)2.94683282
25Vertebral compression fractures (HP:0002953)2.82864907
26Metaphyseal cupping (HP:0003021)2.79462583
27Bladder diverticulum (HP:0000015)2.79182802
28Cerebral aneurysm (HP:0004944)2.78925992
29Abnormality of the ischium (HP:0003174)2.78518177
30Type 1 muscle fiber predominance (HP:0003803)2.75670061
31Abnormality of the acetabulum (HP:0003170)2.73231609
32Dilatation of the ascending aorta (HP:0005111)2.68023866
33Mild short stature (HP:0003502)2.66767329
34Osteoarthritis (HP:0002758)2.65874472
35Coxa vara (HP:0002812)2.64174645
36Mesomelia (HP:0003027)2.63947393
37Fragile skin (HP:0001030)2.63049147
38Platyspondyly (HP:0000926)2.60939418
39Vascular calcification (HP:0004934)2.59717490
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.56348810
41Abnormality of the umbilical cord (HP:0010881)2.53001047
42Peritonitis (HP:0002586)2.51060181
43Abnormal tarsal ossification (HP:0008369)2.50109197
44Vascular tortuosity (HP:0004948)2.47718221
45Mitral stenosis (HP:0001718)2.47348650
46Reduced subcutaneous adipose tissue (HP:0003758)2.47179664
47Microglossia (HP:0000171)2.46652123
48Distal lower limb muscle weakness (HP:0009053)2.46150994
49Flat acetabular roof (HP:0003180)2.44805490
50Mitral valve prolapse (HP:0001634)2.43394017
51Small epiphyses (HP:0010585)2.42495778
52Beaking of vertebral bodies (HP:0004568)2.40883833
53Genu recurvatum (HP:0002816)2.38736583
54Flat capital femoral epiphysis (HP:0003370)2.38002352
55Abnormal foot bone ossification (HP:0010675)2.35235305
56Abnormalities of placenta or umbilical cord (HP:0001194)2.24209925
57Popliteal pterygium (HP:0009756)2.23328651
58Delayed epiphyseal ossification (HP:0002663)2.21319222
59Wide anterior fontanel (HP:0000260)2.19923780
60Increased connective tissue (HP:0009025)2.19516220
61Metaphyseal dysplasia (HP:0100255)2.19094831
62Abnormal vertebral ossification (HP:0100569)2.19064469
63Ulnar bowing (HP:0003031)2.18227349
64Abnormal umbilical cord blood vessels (HP:0011403)2.17887698
65Single umbilical artery (HP:0001195)2.17887698
66Abnormality of the fetal cardiovascular system (HP:0010948)2.17887698
67Hip contracture (HP:0003273)2.17843145
68Thoracolumbar scoliosis (HP:0002944)2.17466584
69Arterial tortuosity (HP:0005116)2.16143500
70Nonimmune hydrops fetalis (HP:0001790)2.14701136
71Radial bowing (HP:0002986)2.11148521
72Broad long bones (HP:0005622)2.10882443
73Abnormality of carpal bone ossification (HP:0006257)2.09917264
74Increased serum pyruvate (HP:0003542)2.09201797
75Alopecia of scalp (HP:0002293)2.08513576
76Abnormality of the calcaneus (HP:0008364)2.07073255
77Decreased skull ossification (HP:0004331)2.06297478
78Abnormality of glycolysis (HP:0004366)2.06260540
79Pterygium (HP:0001059)2.04105688
80Trismus (HP:0000211)2.02460664
81Breech presentation (HP:0001623)2.02306881
82Genu varum (HP:0002970)2.01925441
83Wrist flexion contracture (HP:0001239)2.01889725
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.01668728
85Short 4th metacarpal (HP:0010044)2.01668728
86Abnormal ossification of hand bones (HP:0005921)2.01429935
87Delayed gross motor development (HP:0002194)2.00703607
88Osteolytic defects of the hand bones (HP:0009699)1.99591056
89Osteolytic defects of the phalanges of the hand (HP:0009771)1.99591056
90Joint laxity (HP:0001388)1.99496082
91Flattened epiphyses (HP:0003071)1.98588683
92Abnormality of placental membranes (HP:0011409)1.97999344
93Amniotic constriction ring (HP:0009775)1.97999344
94Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97749845
95Abnormality of the 2nd finger (HP:0004100)1.97739031
96Mildly elevated creatine phosphokinase (HP:0008180)1.95539525
97Exercise-induced muscle cramps (HP:0003710)1.93819357
98Ectopia lentis (HP:0001083)1.93428933
99Abnormality of the distal phalanges of the toes (HP:0010182)1.93410902
100Exostoses (HP:0100777)1.92076776
101Limited hip movement (HP:0008800)1.92007951
102Elbow flexion contracture (HP:0002987)1.91952328
103Spondylolisthesis (HP:0003302)1.90991865
104Hyperextensible skin (HP:0000974)1.89517320
105Spinal cord compression (HP:0002176)1.88374023
106Hypoplastic left heart (HP:0004383)1.88363601
107Overgrowth (HP:0001548)1.88164188
108Spinal cord lesions (HP:0100561)1.87539265
109Syringomyelia (HP:0003396)1.87539265
110Hypoalphalipoproteinemia (HP:0003233)1.87386575
111Nemaline bodies (HP:0003798)1.87129025
112Broad phalanx (HP:0006009)1.85893160
113Asymmetry of the thorax (HP:0001555)1.85836058
114Generalized amyotrophy (HP:0003700)1.85451841
115Abnormal delivery (HP:0001787)1.84862679
116Sparse eyelashes (HP:0000653)1.84695625
117Reduced antithrombin III activity (HP:0001976)1.84671985
118Redundant skin (HP:0001582)1.84301247
119Abnormality of skull ossification (HP:0002703)1.83968676
120Glossoptosis (HP:0000162)1.83892547
121Joint stiffness (HP:0001387)1.83719119
122Hyporeflexia of lower limbs (HP:0002600)1.82484946
123Type I transferrin isoform profile (HP:0003642)1.80171455
124Slender build (HP:0001533)1.80072382
125Abnormal hand bone ossification (HP:0010660)1.79898397
126Asymmetric septal hypertrophy (HP:0001670)1.79631025
127Absent frontal sinuses (HP:0002688)1.78583736
128Delayed cranial suture closure (HP:0000270)1.77469019
129Bowed forearm bones (HP:0003956)1.77132013
130Bowing of the arm (HP:0006488)1.77132013
131Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77008249
132Infantile muscular hypotonia (HP:0008947)1.75455245
133Knee flexion contracture (HP:0006380)1.75431680
134Ventricular tachycardia (HP:0004756)1.75242646
135Neck muscle weakness (HP:0000467)1.74524499
136Lipoatrophy (HP:0100578)1.74189387
137Pulmonary artery stenosis (HP:0004415)1.73713633
138Abnormality of the calf musculature (HP:0001430)1.72673225
139Thin bony cortex (HP:0002753)1.72525619
140Short nail (HP:0001799)1.72443929
141Short hallux (HP:0010109)1.72346517
142Abnormality of proline metabolism (HP:0010907)1.70666279
143Hydroxyprolinuria (HP:0003080)1.70666279
144Aplasia of the musculature (HP:0100854)1.70562210
145Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70152337
146Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69287936
147Hypokinesia (HP:0002375)1.67910940
148Hypoplasia of the iris (HP:0007676)1.66847621
149Hypoplastic heart (HP:0001961)1.63695850
150Bifid uvula (HP:0000193)1.61117139
151Ovoid vertebral bodies (HP:0003300)1.60731504
152Coronal craniosynostosis (HP:0004440)1.60310290
153Intrahepatic cholestasis (HP:0001406)1.59955122
154Congenital ichthyosiform erythroderma (HP:0007431)1.59052165
155Round ear (HP:0100830)1.58000033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.23265055
2MAP3K123.17715106
3MST1R3.06978759
4TIE12.89992523
5KDR2.69601992
6PBK2.69184547
7MAP3K32.64792826
8LATS12.46945279
9TGFBR12.44848986
10LMTK22.36016457
11TGFBR22.26158088
12EPHB22.21382531
13TRIB32.14468116
14VRK22.11407488
15STK38L2.10615865
16MYLK2.08598309
17TTN2.06896986
18MUSK2.06344903
19PDGFRA2.00621343
20PKN21.97879022
21PIM21.95736163
22NME21.93078276
23TESK11.90800896
24PAK41.89370564
25LATS21.84775636
26RPS6KA41.80735266
27ERBB31.78088197
28ERN11.74859007
29TRPM71.69199478
30PAK21.62787134
31EPHA21.61822571
32LRRK21.60121169
33MAP2K31.57104063
34STK31.56103520
35STK161.48197720
36FER1.38844370
37ILK1.36904931
38LIMK11.34983743
39ERBB41.29212484
40ZAK1.28786956
41NEK91.27745018
42STK241.27613708
43RIPK11.26674353
44PRKG21.25954243
45EPHA31.21701832
46TRIM281.20845526
47PIK3CA1.20123128
48NUAK11.15547348
49FRK1.13847756
50PTK2B1.13811523
51PTK21.10893541
52MET1.07873625
53PTK61.04573353
54EIF2AK11.01194410
55MKNK11.01141986
56BUB11.00942180
57FGFR11.00724822
58RPS6KB21.00234893
59TAOK20.99141284
60EIF2AK30.96669106
61MAPKAPK50.94391971
62NTRK10.93684495
63ARAF0.93290535
64STK100.91963171
65IRAK30.90315296
66FLT30.86161725
67SIK10.85020856
68BRSK20.83089589
69STK390.80831799
70ROCK10.80329141
71BMX0.78719145
72PDGFRB0.77914308
73NEK60.77569364
74ACVR1B0.77557337
75CDK80.71698611
76CDK60.71493221
77CDK70.71316617
78NME10.71188017
79PDK20.70358216
80MAP3K80.69943319
81WEE10.68224496
82BCKDK0.64963058
83CAMK2G0.64827608
84MOS0.63299505
85AURKB0.62685756
86SIK30.59067574
87MAPKAPK30.57910563
88BRSK10.55935663
89PASK0.55797284
90PRKCI0.55634681
91BCR0.55243450
92CAMK2D0.54649768
93SCYL20.53986375
94PLK30.53581274
95PLK20.52776628
96MELK0.51799255
97OBSCN0.51638922
98MTOR0.51420099
99MAP2K10.51144626
100DMPK0.49810270
101PRKCE0.49588556
102DAPK10.49371196
103TTK0.48737018
104EIF2AK20.46565308
105MAP3K110.46473336
106CDK90.46197101
107PAK10.45792107
108ADRBK10.45579786
109STK380.44449585
110AKT20.44298358
111MAP3K100.42731193
112PIK3CG0.42396991
113PLK40.42174650
114BMPR1B0.41799952
115MST40.40303163
116PHKG10.39895184
117PHKG20.39895184
118PAK30.39138828
119PIM10.38810711
120NEK10.36989998
121DAPK30.36695313
122MAP3K20.36527184
123INSRR0.36160209
124INSR0.35554642
125IGF1R0.35233936
126ABL20.34465418
127PRKD10.34452120
128JAK30.33633584
129CHUK0.33632283
130DYRK1B0.32047396
131PLK10.31807696
132MKNK20.31000950
133FGFR30.30270374
134GSK3A0.29286844
135ROCK20.28292975
136EEF2K0.26678295

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.40383866
2Protein digestion and absorption_Homo sapiens_hsa049743.45208594
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.09831895
4Sulfur metabolism_Homo sapiens_hsa009202.86981009
5Focal adhesion_Homo sapiens_hsa045102.81173091
6TGF-beta signaling pathway_Homo sapiens_hsa043502.28630713
7Ribosome_Homo sapiens_hsa030102.18522024
8Adherens junction_Homo sapiens_hsa045202.07742376
9Small cell lung cancer_Homo sapiens_hsa052222.04029931
10Proteoglycans in cancer_Homo sapiens_hsa052051.94978747
11Fatty acid elongation_Homo sapiens_hsa000621.91778960
12Hippo signaling pathway_Homo sapiens_hsa043901.87375589
13Malaria_Homo sapiens_hsa051441.77757060
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77355894
15Pyruvate metabolism_Homo sapiens_hsa006201.74048803
16Basal cell carcinoma_Homo sapiens_hsa052171.73913764
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73151521
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.68893649
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65726478
20Oxidative phosphorylation_Homo sapiens_hsa001901.64123839
21p53 signaling pathway_Homo sapiens_hsa041151.63175543
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59496949
23Cell cycle_Homo sapiens_hsa041101.56742551
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56697729
25Bladder cancer_Homo sapiens_hsa052191.56510311
26Sulfur relay system_Homo sapiens_hsa041221.55613408
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48601751
28MicroRNAs in cancer_Homo sapiens_hsa052061.47509049
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47189689
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.46090609
31Protein export_Homo sapiens_hsa030601.40959405
32Dilated cardiomyopathy_Homo sapiens_hsa054141.38042734
33DNA replication_Homo sapiens_hsa030301.37708829
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37510815
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.37461035
36Amoebiasis_Homo sapiens_hsa051461.35600949
37Parkinsons disease_Homo sapiens_hsa050121.33932915
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32026923
39Chemical carcinogenesis_Homo sapiens_hsa052041.31631630
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29079568
41Carbon metabolism_Homo sapiens_hsa012001.28876747
42Hedgehog signaling pathway_Homo sapiens_hsa043401.28532401
43Complement and coagulation cascades_Homo sapiens_hsa046101.27800087
44Vibrio cholerae infection_Homo sapiens_hsa051101.26338927
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26302245
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.26229388
47Propanoate metabolism_Homo sapiens_hsa006401.25616735
48Viral myocarditis_Homo sapiens_hsa054161.24411356
49Proteasome_Homo sapiens_hsa030501.24336317
50Pentose phosphate pathway_Homo sapiens_hsa000301.20705630
51Biosynthesis of amino acids_Homo sapiens_hsa012301.19421615
52RNA transport_Homo sapiens_hsa030131.19014245
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13892969
54Pathways in cancer_Homo sapiens_hsa052001.13175128
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11811492
56HTLV-I infection_Homo sapiens_hsa051661.10533649
57Fructose and mannose metabolism_Homo sapiens_hsa000511.10004585
58Tight junction_Homo sapiens_hsa045301.08642239
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07980076
60Alzheimers disease_Homo sapiens_hsa050101.07825670
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.07577389
62Huntingtons disease_Homo sapiens_hsa050161.07524219
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.06863958
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06770919
65Shigellosis_Homo sapiens_hsa051311.06663807
66Fatty acid degradation_Homo sapiens_hsa000711.05506167
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.04599462
68Tyrosine metabolism_Homo sapiens_hsa003501.03428099
69Thyroid cancer_Homo sapiens_hsa052161.03381105
70Phenylalanine metabolism_Homo sapiens_hsa003601.01485792
71Glutathione metabolism_Homo sapiens_hsa004801.00515661
72Base excision repair_Homo sapiens_hsa034100.98782150
73Retinol metabolism_Homo sapiens_hsa008300.98531366
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98208904
75HIF-1 signaling pathway_Homo sapiens_hsa040660.97928000
76Mismatch repair_Homo sapiens_hsa034300.97913776
77Melanoma_Homo sapiens_hsa052180.97744253
78Chronic myeloid leukemia_Homo sapiens_hsa052200.96951774
79Arginine biosynthesis_Homo sapiens_hsa002200.95882571
80Prostate cancer_Homo sapiens_hsa052150.95718687
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94801375
82Nucleotide excision repair_Homo sapiens_hsa034200.94317517
83N-Glycan biosynthesis_Homo sapiens_hsa005100.94261997
84Renin-angiotensin system_Homo sapiens_hsa046140.92821085
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92133368
86One carbon pool by folate_Homo sapiens_hsa006700.89819492
87Mineral absorption_Homo sapiens_hsa049780.89698648
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89588593
89Sphingolipid metabolism_Homo sapiens_hsa006000.89354542
90Toxoplasmosis_Homo sapiens_hsa051450.88733937
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86636841
92Platelet activation_Homo sapiens_hsa046110.85736095
93TNF signaling pathway_Homo sapiens_hsa046680.83308098
94Cardiac muscle contraction_Homo sapiens_hsa042600.82291868
95Spliceosome_Homo sapiens_hsa030400.81951710
96Legionellosis_Homo sapiens_hsa051340.80413820
97Rap1 signaling pathway_Homo sapiens_hsa040150.80259020
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79792963
99Notch signaling pathway_Homo sapiens_hsa043300.79683274
100Fat digestion and absorption_Homo sapiens_hsa049750.76360332
101Histidine metabolism_Homo sapiens_hsa003400.75879578
102Wnt signaling pathway_Homo sapiens_hsa043100.75723321
103Viral carcinogenesis_Homo sapiens_hsa052030.75599117
104Caffeine metabolism_Homo sapiens_hsa002320.75206200
105beta-Alanine metabolism_Homo sapiens_hsa004100.73748212
106Metabolic pathways_Homo sapiens_hsa011000.72080072
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71989447
108PPAR signaling pathway_Homo sapiens_hsa033200.71195469
109Peroxisome_Homo sapiens_hsa041460.70385895
110Lysosome_Homo sapiens_hsa041420.68843438
111Apoptosis_Homo sapiens_hsa042100.68614741
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67866988
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67364186
114Vitamin B6 metabolism_Homo sapiens_hsa007500.67165456
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66807824
116Arachidonic acid metabolism_Homo sapiens_hsa005900.66489017
117Tryptophan metabolism_Homo sapiens_hsa003800.62359898
118Hepatitis B_Homo sapiens_hsa051610.61880755
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61840171
120Pancreatic cancer_Homo sapiens_hsa052120.61211844
121Steroid biosynthesis_Homo sapiens_hsa001000.60552640
122RNA degradation_Homo sapiens_hsa030180.60197853
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59536658
124Pyrimidine metabolism_Homo sapiens_hsa002400.59407083
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58529112
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57254017
127Galactose metabolism_Homo sapiens_hsa000520.56787093
128Colorectal cancer_Homo sapiens_hsa052100.56219739
129Vitamin digestion and absorption_Homo sapiens_hsa049770.54251493
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.53575165
131Epstein-Barr virus infection_Homo sapiens_hsa051690.51353636
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50420227
133Fatty acid metabolism_Homo sapiens_hsa012120.50281282
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48185825
135RNA polymerase_Homo sapiens_hsa030200.46946433
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46623599
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44501193
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43126810
139Homologous recombination_Homo sapiens_hsa034400.39708512
140Folate biosynthesis_Homo sapiens_hsa007900.37970352
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37873682
142Endometrial cancer_Homo sapiens_hsa052130.37666822
143Starch and sucrose metabolism_Homo sapiens_hsa005000.36870771
144Leishmaniasis_Homo sapiens_hsa051400.36470973
145Herpes simplex infection_Homo sapiens_hsa051680.35877873
146Phagosome_Homo sapiens_hsa041450.35764601
147Other glycan degradation_Homo sapiens_hsa005110.34099977
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.33544395
149Thyroid hormone synthesis_Homo sapiens_hsa049180.31755455
150FoxO signaling pathway_Homo sapiens_hsa040680.30562904
151Arginine and proline metabolism_Homo sapiens_hsa003300.30276604
152Salmonella infection_Homo sapiens_hsa051320.29369997
153Melanogenesis_Homo sapiens_hsa049160.29089575
154Hematopoietic cell lineage_Homo sapiens_hsa046400.25496036
155Selenocompound metabolism_Homo sapiens_hsa004500.24473960

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