PPID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.77944814
2DNA replication initiation (GO:0006270)4.72611553
3DNA unwinding involved in DNA replication (GO:0006268)4.69739019
4DNA strand elongation involved in DNA replication (GO:0006271)4.59626141
5purine nucleobase biosynthetic process (GO:0009113)4.51340468
6maturation of SSU-rRNA (GO:0030490)4.45640720
7formation of translation preinitiation complex (GO:0001731)4.37638112
8IMP biosynthetic process (GO:0006188)4.37211300
9DNA strand elongation (GO:0022616)4.36589748
10CENP-A containing nucleosome assembly (GO:0034080)4.27914416
11telomere maintenance via semi-conservative replication (GO:0032201)4.27528601
12ribosome assembly (GO:0042255)4.25468975
13chromatin remodeling at centromere (GO:0031055)4.25252434
14ribosomal small subunit assembly (GO:0000028)4.21129702
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17884671
16ribosome biogenesis (GO:0042254)4.15470622
17establishment of integrated proviral latency (GO:0075713)4.11427356
18DNA replication checkpoint (GO:0000076)4.10945159
19ribosomal large subunit biogenesis (GO:0042273)4.04127034
20ribonucleoprotein complex biogenesis (GO:0022613)4.00927636
21protein localization to kinetochore (GO:0034501)3.98979708
22nuclear pore organization (GO:0006999)3.97362791
23mitotic metaphase plate congression (GO:0007080)3.94536805
24spliceosomal snRNP assembly (GO:0000387)3.89236243
25telomere maintenance via recombination (GO:0000722)3.86805644
26IMP metabolic process (GO:0046040)3.85147947
27DNA replication-independent nucleosome assembly (GO:0006336)3.77429487
28DNA replication-independent nucleosome organization (GO:0034724)3.77429487
29kinetochore organization (GO:0051383)3.77249912
30DNA double-strand break processing (GO:0000729)3.74625504
31mitotic recombination (GO:0006312)3.74173111
32mitotic nuclear envelope disassembly (GO:0007077)3.73560740
33ribosomal small subunit biogenesis (GO:0042274)3.70561793
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70116647
35DNA replication-dependent nucleosome organization (GO:0034723)3.70008019
36DNA replication-dependent nucleosome assembly (GO:0006335)3.70008019
37nuclear pore complex assembly (GO:0051292)3.69055060
38rRNA processing (GO:0006364)3.67860691
39DNA damage response, detection of DNA damage (GO:0042769)3.65072189
40folic acid-containing compound biosynthetic process (GO:0009396)3.63572910
41translational termination (GO:0006415)3.63272151
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63206712
43proteasome assembly (GO:0043248)3.63118798
44pseudouridine synthesis (GO:0001522)3.62509368
45viral transcription (GO:0019083)3.61128840
46protein neddylation (GO:0045116)3.60134553
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59877070
48ATP synthesis coupled proton transport (GO:0015986)3.59877070
49histone exchange (GO:0043486)3.58729118
50chaperone-mediated protein transport (GO:0072321)3.57193437
51metaphase plate congression (GO:0051310)3.57016389
52telomere maintenance via telomere lengthening (GO:0010833)3.56131604
53rRNA metabolic process (GO:0016072)3.54567852
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51844832
55regulation of mitotic spindle checkpoint (GO:1903504)3.51844832
56DNA deamination (GO:0045006)3.49822316
57maturation of 5.8S rRNA (GO:0000460)3.47405245
58translational initiation (GO:0006413)3.47326027
59nuclear envelope disassembly (GO:0051081)3.45839085
60membrane disassembly (GO:0030397)3.45839085
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.42244915
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40325289
63cullin deneddylation (GO:0010388)3.39812847
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39751937
65translational elongation (GO:0006414)3.37347215
66kinetochore assembly (GO:0051382)3.36762214
67spliceosomal complex assembly (GO:0000245)3.36415032
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33656554
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.33165289
70respiratory chain complex IV assembly (GO:0008535)3.31303173
71DNA ligation (GO:0006266)3.30296733
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.29726092
73attachment of spindle microtubules to kinetochore (GO:0008608)3.28917211
74protein localization to chromosome, centromeric region (GO:0071459)3.28913940
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26904769
76transcription-coupled nucleotide-excision repair (GO:0006283)3.26092757
77regulation of cellular amino acid metabolic process (GO:0006521)3.25760072
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.25658913
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25658913
80viral mRNA export from host cell nucleus (GO:0046784)3.24901745
81termination of RNA polymerase III transcription (GO:0006386)3.24066253
82transcription elongation from RNA polymerase III promoter (GO:0006385)3.24066253
83rRNA modification (GO:0000154)3.23078103
84mitotic sister chromatid segregation (GO:0000070)3.22095301
85protein targeting to mitochondrion (GO:0006626)3.21971052
86transcription elongation from RNA polymerase I promoter (GO:0006362)3.21208705
87cellular component biogenesis (GO:0044085)3.20708548
88transcription from mitochondrial promoter (GO:0006390)3.20123121
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19850159
90establishment of chromosome localization (GO:0051303)3.19691036
91mitochondrial respiratory chain complex assembly (GO:0033108)3.19135874
92negative regulation of DNA-dependent DNA replication (GO:2000104)3.19120068
93water-soluble vitamin biosynthetic process (GO:0042364)3.18095784
947-methylguanosine mRNA capping (GO:0006370)3.16389608
95DNA catabolic process, exonucleolytic (GO:0000738)3.15891937
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15399573
97G1/S transition of mitotic cell cycle (GO:0000082)3.15374903
98cell cycle G1/S phase transition (GO:0044843)3.15374903
997-methylguanosine RNA capping (GO:0009452)3.15027778
100RNA capping (GO:0036260)3.15027778
101protein deneddylation (GO:0000338)3.14521066
102organelle disassembly (GO:1903008)3.13799027
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13766123
104protein complex biogenesis (GO:0070271)3.12794412
105RNA splicing, via transesterification reactions (GO:0000375)3.12309584
106DNA duplex unwinding (GO:0032508)3.12135954
107termination of RNA polymerase I transcription (GO:0006363)3.11978504
108regulation of centriole replication (GO:0046599)3.11378718
109negative regulation of ligase activity (GO:0051352)3.11013529
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11013529
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.10821712
112mRNA splicing, via spliceosome (GO:0000398)3.10821712
113DNA geometric change (GO:0032392)3.10719747
114mitochondrial RNA metabolic process (GO:0000959)3.08969312
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08446405
116mitochondrial respiratory chain complex I assembly (GO:0032981)3.07708769
117NADH dehydrogenase complex assembly (GO:0010257)3.07708769
118mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07708769
119protein localization to mitochondrion (GO:0070585)3.07373513
120establishment of viral latency (GO:0019043)3.06883836
121regulation of centrosome cycle (GO:0046605)3.05437706
122cotranslational protein targeting to membrane (GO:0006613)3.04031283
123histone mRNA metabolic process (GO:0008334)3.03453459
124positive regulation of ligase activity (GO:0051351)3.01825877
125translation (GO:0006412)3.01824707
126respiratory electron transport chain (GO:0022904)3.01321946
127spindle checkpoint (GO:0031577)3.01074779
128negative regulation of mitotic sister chromatid separation (GO:2000816)3.00633273
129negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00633273
130negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00633273
131negative regulation of sister chromatid segregation (GO:0033046)3.00633273
132cellular protein complex disassembly (GO:0043624)3.00256659
133protein targeting to ER (GO:0045047)2.99619414
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99305408
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99305408
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99305408
137oxidative phosphorylation (GO:0006119)2.99173576
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98369742
139establishment of protein localization to mitochondrion (GO:0072655)2.95492517
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94141884
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94141884
142electron transport chain (GO:0022900)2.93894128
143regulation of mitochondrial translation (GO:0070129)2.90079249
144tRNA aminoacylation for protein translation (GO:0006418)2.89887349
145signal transduction involved in cell cycle checkpoint (GO:0072395)2.89840682
146replication fork processing (GO:0031297)2.89441070
147tRNA aminoacylation (GO:0043039)2.89212923
148amino acid activation (GO:0043038)2.89212923
149signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88855430
150signal transduction involved in DNA damage checkpoint (GO:0072422)2.88855430
151regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.88804474
152regulation of ubiquitin-protein transferase activity (GO:0051438)2.86924288
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85843415
154isotype switching (GO:0045190)2.85843415
155somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85843415
156peptidyl-histidine modification (GO:0018202)2.85322871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72495296
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.83309532
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95562198
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83697656
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.75061089
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.54827705
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.41685139
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31732997
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.28740695
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.15926705
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.15084955
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.13509260
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04756262
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96850978
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96750295
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95681209
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65338281
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56165914
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48585711
20VDR_23849224_ChIP-Seq_CD4+_Human2.47085091
21XRN2_22483619_ChIP-Seq_HELA_Human2.44373250
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28638124
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21248527
24FOXP3_21729870_ChIP-Seq_TREG_Human2.18482751
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15883042
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14928775
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14417617
28DCP1A_22483619_ChIP-Seq_HELA_Human2.12888591
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11258355
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10512491
31* AR_21909140_ChIP-Seq_LNCAP_Human2.09916050
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08554163
33RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07968373
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07290364
35TTF2_22483619_ChIP-Seq_HELA_Human2.03251905
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02998609
37MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02832003
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.99063069
39ELK1_19687146_ChIP-ChIP_HELA_Human1.98421292
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97563567
41* GABP_19822575_ChIP-Seq_HepG2_Human1.93899893
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87148641
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86456285
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78441524
45* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73446115
46ZNF274_21170338_ChIP-Seq_K562_Hela1.72689532
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.71724120
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67783338
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62776995
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60821574
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.58966707
52* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55233302
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53219087
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50597251
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48373653
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46332086
57CIITA_25753668_ChIP-Seq_RAJI_Human1.46091774
58EWS_26573619_Chip-Seq_HEK293_Human1.45664386
59KDM5A_27292631_Chip-Seq_BREAST_Human1.44796505
60* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41192991
61VDR_22108803_ChIP-Seq_LS180_Human1.40035521
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.39994620
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37112032
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33304279
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.32671282
66FUS_26573619_Chip-Seq_HEK293_Human1.31236767
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29791992
68MYC_18940864_ChIP-ChIP_HL60_Human1.21280440
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20846214
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19324893
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18880036
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15598458
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15259893
74IGF1R_20145208_ChIP-Seq_DFB_Human1.12946905
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12025011
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10935978
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10182060
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09051495
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08866483
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08759450
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07878781
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.03353402
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.02524289
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02492635
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01753532
86* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01190065
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.00639671
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00374103
89TFEB_21752829_ChIP-Seq_HELA_Human1.00043181
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99534609
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98809434
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96507617
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94251087
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93319958
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93014867
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92433717
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.90376863
98TP53_22573176_ChIP-Seq_HFKS_Human0.86924980
99MYC_22102868_ChIP-Seq_BL_Human0.86750499
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85634870
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85132103
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84682899
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83078338
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82807441
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81675038
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81490017
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80689474
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79599433
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79543601
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.78474968
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78296588
112IRF1_19129219_ChIP-ChIP_H3396_Human0.77969765
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.77731861
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77285140
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76627097
116TAF15_26573619_Chip-Seq_HEK293_Human0.76378601
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76356738
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.76067119
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.76023300
120P300_19829295_ChIP-Seq_ESCs_Human0.75314780
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75057355
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.73635178
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73468263
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.73398769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.58351033
2MP0010094_abnormal_chromosome_stability5.10142118
3MP0004957_abnormal_blastocyst_morpholog4.99644033
4MP0003111_abnormal_nucleus_morphology4.53936035
5MP0008057_abnormal_DNA_replication4.36810379
6MP0003077_abnormal_cell_cycle4.11151217
7MP0008058_abnormal_DNA_repair4.02196118
8MP0003123_paternal_imprinting3.28096393
9MP0008007_abnormal_cellular_replicative3.07487116
10MP0008932_abnormal_embryonic_tissue3.05989434
11MP0008877_abnormal_DNA_methylation3.04494014
12MP0001730_embryonic_growth_arrest2.45737885
13MP0002396_abnormal_hematopoietic_system2.30653280
14MP0000350_abnormal_cell_proliferation2.26197665
15MP0003786_premature_aging2.17074695
16MP0003121_genomic_imprinting2.12157760
17MP0003806_abnormal_nucleotide_metabolis2.04639566
18MP0006072_abnormal_retinal_apoptosis1.89786323
19MP0003195_calcinosis1.77911513
20MP0001697_abnormal_embryo_size1.75103278
21MP0001672_abnormal_embryogenesis/_devel1.72321511
22MP0005380_embryogenesis_phenotype1.72321511
23MP0010352_gastrointestinal_tract_polyps1.67452695
24MP0003718_maternal_effect1.63106744
25MP0002080_prenatal_lethality1.62283472
26MP0006292_abnormal_olfactory_placode1.60858919
27MP0003890_abnormal_embryonic-extraembry1.57090868
28MP0003984_embryonic_growth_retardation1.53614214
29MP0002085_abnormal_embryonic_tissue1.52264499
30MP0003567_abnormal_fetal_cardiomyocyte1.49169839
31MP0002088_abnormal_embryonic_growth/wei1.49018935
32MP0002084_abnormal_developmental_patter1.47498258
33MP0001529_abnormal_vocalization1.41121821
34MP0004197_abnormal_fetal_growth/weight/1.39170541
35MP0002837_dystrophic_cardiac_calcinosis1.38440100
36MP0000313_abnormal_cell_death1.38162427
37MP0010307_abnormal_tumor_latency1.36953655
38MP0001293_anophthalmia1.36581361
39MP0000372_irregular_coat_pigmentation1.32245424
40MP0002210_abnormal_sex_determination1.30027496
41MP0002160_abnormal_reproductive_system1.29566975
42MP0005084_abnormal_gallbladder_morpholo1.25214412
43MP0002086_abnormal_extraembryonic_tissu1.24671314
44MP0004215_abnormal_myocardial_fiber1.23704806
45MP0000490_abnormal_crypts_of1.23036863
46MP0009697_abnormal_copulation1.22386792
47MP0002638_abnormal_pupillary_reflex1.22083976
48MP0005253_abnormal_eye_physiology1.20910639
49MP0002736_abnormal_nociception_after1.18828683
50MP0004145_abnormal_muscle_electrophysio1.16910183
51MP0004133_heterotaxia1.15261724
52MP0004808_abnormal_hematopoietic_stem1.14968266
53MP0001145_abnormal_male_reproductive1.14830378
54MP0002019_abnormal_tumor_incidence1.13923677
55MP0005085_abnormal_gallbladder_physiolo1.13774522
56MP0002938_white_spotting1.12360702
57MP0000537_abnormal_urethra_morphology1.09093705
58MP0003315_abnormal_perineum_morphology1.08605956
59MP0009379_abnormal_foot_pigmentation1.07306488
60MP0004147_increased_porphyrin_level1.05349267
61MP0006035_abnormal_mitochondrial_morpho1.05277732
62MP0001764_abnormal_homeostasis1.04093911
63MP0006276_abnormal_autonomic_nervous1.03924521
64MP0003646_muscle_fatigue1.03557730
65MP0006054_spinal_hemorrhage1.03418326
66MP0006036_abnormal_mitochondrial_physio1.02959442
67MP0008875_abnormal_xenobiotic_pharmacok1.02359241
68MP0005332_abnormal_amino_acid1.02220235
69MP0010030_abnormal_orbit_morphology1.00611653
70MP0000653_abnormal_sex_gland0.99107692
71MP0001929_abnormal_gametogenesis0.98991235
72MP0003122_maternal_imprinting0.98258186
73MP0000358_abnormal_cell_content/0.97969825
74MP0000647_abnormal_sebaceous_gland0.94352356
75MP0003787_abnormal_imprinting0.93902340
76MP0003119_abnormal_digestive_system0.93180507
77MP0003011_delayed_dark_adaptation0.92816179
78MP0008872_abnormal_physiological_respon0.91329745
79MP0002653_abnormal_ependyma_morphology0.90887500
80MP0005389_reproductive_system_phenotype0.90788730
81MP0002102_abnormal_ear_morphology0.89557862
82MP0001188_hyperpigmentation0.87698992
83MP0003221_abnormal_cardiomyocyte_apopto0.87483394
84MP0005551_abnormal_eye_electrophysiolog0.86175912
85MP0002090_abnormal_vision0.83633372
86MP0002234_abnormal_pharynx_morphology0.82687084
87MP0000749_muscle_degeneration0.82506688
88MP0001984_abnormal_olfaction0.82402269
89MP0009672_abnormal_birth_weight0.82254378
90MP0005266_abnormal_metabolism0.81341073
91MP0000703_abnormal_thymus_morphology0.81323475
92MP0003186_abnormal_redox_activity0.81318488
93MP0003937_abnormal_limbs/digits/tail_de0.80110991
94MP0002111_abnormal_tail_morphology0.79950180
95MP0005397_hematopoietic_system_phenotyp0.79451500
96MP0001545_abnormal_hematopoietic_system0.79451500
97MP0002751_abnormal_autonomic_nervous0.78254062
98MP0002095_abnormal_skin_pigmentation0.77986299
99MP0009333_abnormal_splenocyte_physiolog0.77194896
100MP0005384_cellular_phenotype0.76680711
101MP0008789_abnormal_olfactory_epithelium0.76286806
102MP0005636_abnormal_mineral_homeostasis0.76132496
103MP0009053_abnormal_anal_canal0.75987620
104MP0005365_abnormal_bile_salt0.75276616
105MP0002233_abnormal_nose_morphology0.70904271
106MP0008995_early_reproductive_senescence0.70859718
107MP0009703_decreased_birth_body0.70005403
108MP0005395_other_phenotype0.68978410
109MP0002139_abnormal_hepatobiliary_system0.67969324
110MP0003861_abnormal_nervous_system0.67910132
111MP0003136_yellow_coat_color0.66946504
112MP0001286_abnormal_eye_development0.66145904
113MP0003941_abnormal_skin_development0.66100859
114MP0001485_abnormal_pinna_reflex0.64183237
115MP0002277_abnormal_respiratory_mucosa0.64095780
116MP0008775_abnormal_heart_ventricle0.63997271
117MP0001119_abnormal_female_reproductive0.63383051
118MP0005391_vision/eye_phenotype0.60727459
119MP0005499_abnormal_olfactory_system0.60567558
120MP0005394_taste/olfaction_phenotype0.60567558
121MP0005075_abnormal_melanosome_morpholog0.60510177
122MP0003698_abnormal_male_reproductive0.58921659
123MP0001986_abnormal_taste_sensitivity0.58364003
124MP0001727_abnormal_embryo_implantation0.58162673
125MP0002722_abnormal_immune_system0.57739130
126MP0004233_abnormal_muscle_weight0.56527929
127MP0005621_abnormal_cell_physiology0.55853764
128MP0002398_abnormal_bone_marrow0.54589402
129MP0000689_abnormal_spleen_morphology0.54092529
130MP0002132_abnormal_respiratory_system0.53145282
131MP0003938_abnormal_ear_development0.49959491
132MP0001919_abnormal_reproductive_system0.49760399
133MP0002161_abnormal_fertility/fecundity0.49623721
134MP0003763_abnormal_thymus_physiology0.49565920
135MP0002114_abnormal_axial_skeleton0.49141760

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.32996923
2Abnormality of cells of the erythroid lineage (HP:0012130)4.16330436
3Acute encephalopathy (HP:0006846)4.09131669
4Reticulocytopenia (HP:0001896)3.98298520
5Abnormal number of erythroid precursors (HP:0012131)3.94373688
6Chromsome breakage (HP:0040012)3.88362135
7Breast hypoplasia (HP:0003187)3.65433324
8Colon cancer (HP:0003003)3.63661132
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61336928
10Oral leukoplakia (HP:0002745)3.53035174
11Abnormality of the labia minora (HP:0012880)3.50314129
12Medulloblastoma (HP:0002885)3.43557747
13Lipid accumulation in hepatocytes (HP:0006561)3.24275985
14Abnormality of chromosome stability (HP:0003220)3.23974544
15Abnormality of the preputium (HP:0100587)3.21670007
16Aplastic anemia (HP:0001915)3.21421289
17Cerebral edema (HP:0002181)3.18965805
18Cerebral hypomyelination (HP:0006808)3.17504863
19Selective tooth agenesis (HP:0001592)3.14933426
20Meckel diverticulum (HP:0002245)3.13946363
21Agnosia (HP:0010524)3.10235887
22Hepatic necrosis (HP:0002605)3.00490691
23Patellar aplasia (HP:0006443)2.99795665
24Ependymoma (HP:0002888)2.98072455
25Abnormality of the ileum (HP:0001549)2.97636353
26Methylmalonic acidemia (HP:0002912)2.94941009
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.81799746
28Abnormality of the anterior horn cell (HP:0006802)2.79280927
29Degeneration of anterior horn cells (HP:0002398)2.79280927
30Lactic acidosis (HP:0003128)2.79150578
31Abnormality of glycolysis (HP:0004366)2.78640587
32Increased serum pyruvate (HP:0003542)2.78640587
33Aplasia/Hypoplasia of the patella (HP:0006498)2.77762357
34Macrocytic anemia (HP:0001972)2.76084904
35Carpal bone hypoplasia (HP:0001498)2.72537049
36Myelodysplasia (HP:0002863)2.68586956
37Absent radius (HP:0003974)2.67399045
38Hyperglycinemia (HP:0002154)2.67337786
39Premature graying of hair (HP:0002216)2.64977506
40Abnormality of serum amino acid levels (HP:0003112)2.64244123
41Abnormality of methionine metabolism (HP:0010901)2.62395924
42Absent thumb (HP:0009777)2.61654028
43Rough bone trabeculation (HP:0100670)2.58833253
44Supernumerary spleens (HP:0009799)2.57991601
45Small intestinal stenosis (HP:0012848)2.56656947
46Duodenal stenosis (HP:0100867)2.56656947
47Pallor (HP:0000980)2.54106796
48Absent forearm bone (HP:0003953)2.51061321
49Aplasia involving forearm bones (HP:0009822)2.51061321
50Rhabdomyosarcoma (HP:0002859)2.49775954
51Abnormal number of incisors (HP:0011064)2.49281500
52Type I transferrin isoform profile (HP:0003642)2.45880234
53Acute necrotizing encephalopathy (HP:0006965)2.42539248
54Renal Fanconi syndrome (HP:0001994)2.39587188
55Pancreatic fibrosis (HP:0100732)2.38369476
56Abnormal lung lobation (HP:0002101)2.35756913
5711 pairs of ribs (HP:0000878)2.35376981
58Bone marrow hypocellularity (HP:0005528)2.35213108
59Exercise intolerance (HP:0003546)2.34473470
60Increased serum lactate (HP:0002151)2.34237512
61Increased CSF lactate (HP:0002490)2.33638022
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33303742
63Increased intramyocellular lipid droplets (HP:0012240)2.33139572
64Methylmalonic aciduria (HP:0012120)2.30728492
65Pancreatic cysts (HP:0001737)2.30450604
66Sloping forehead (HP:0000340)2.30395145
67Impulsivity (HP:0100710)2.30242376
68Horseshoe kidney (HP:0000085)2.30156166
69Leukodystrophy (HP:0002415)2.28006254
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27594328
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27594328
72Respiratory failure (HP:0002878)2.25311529
73Medial flaring of the eyebrow (HP:0010747)2.25154790
74Abnormal mitochondria in muscle tissue (HP:0008316)2.24799193
75Neoplasm of the pancreas (HP:0002894)2.21147148
76Microvesicular hepatic steatosis (HP:0001414)2.21097785
77Cellular immunodeficiency (HP:0005374)2.21018939
78Mitochondrial inheritance (HP:0001427)2.20934912
79Lethargy (HP:0001254)2.18909386
80Abnormal protein N-linked glycosylation (HP:0012347)2.15641511
81Abnormal protein glycosylation (HP:0012346)2.15641511
82Abnormal glycosylation (HP:0012345)2.15641511
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15641511
84Abnormality of glycine metabolism (HP:0010895)2.15585199
85Abnormality of serine family amino acid metabolism (HP:0010894)2.15585199
86Abnormality of the duodenum (HP:0002246)2.15471210
87CNS hypomyelination (HP:0003429)2.15201171
88Increased hepatocellular lipid droplets (HP:0006565)2.14469070
89Volvulus (HP:0002580)2.13614799
90Triphalangeal thumb (HP:0001199)2.12662577
91Exercise-induced muscle cramps (HP:0003710)2.12322926
92Hyperglycinuria (HP:0003108)2.11654421
93Hepatocellular necrosis (HP:0001404)2.10474621
94Atresia of the external auditory canal (HP:0000413)2.09628426
95Proximal placement of thumb (HP:0009623)2.09472265
96Cortical dysplasia (HP:0002539)2.08267287
97Reduced antithrombin III activity (HP:0001976)2.07756941
98Neoplasm of the adrenal gland (HP:0100631)2.07545188
99Molar tooth sign on MRI (HP:0002419)2.07252904
100Abnormality of midbrain morphology (HP:0002418)2.07252904
101True hermaphroditism (HP:0010459)2.06741046
102Congenital primary aphakia (HP:0007707)2.06676189
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06428487
104Abnormality of alanine metabolism (HP:0010916)2.06428487
105Hyperalaninemia (HP:0003348)2.06428487
106Duplicated collecting system (HP:0000081)2.05748555
107Abnormality of the heme biosynthetic pathway (HP:0010472)2.04769040
108Palpitations (HP:0001962)2.03006770
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02749783
110Postnatal microcephaly (HP:0005484)2.01148374
111Pancytopenia (HP:0001876)2.00154421
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99537377
113Microretrognathia (HP:0000308)1.98973000
114Basal cell carcinoma (HP:0002671)1.98664875
115Nemaline bodies (HP:0003798)1.97298092
116Tracheoesophageal fistula (HP:0002575)1.96968083
117Trismus (HP:0000211)1.96683630
118Optic disc pallor (HP:0000543)1.96245874
119Deviation of the thumb (HP:0009603)1.95525587
120Amaurosis fugax (HP:0100576)1.95358244
121Neoplasm of the colon (HP:0100273)1.94619384
122Respiratory difficulties (HP:0002880)1.94239090
123Nephroblastoma (Wilms tumor) (HP:0002667)1.94005530
124Ectopic kidney (HP:0000086)1.94005346
125Irregular epiphyses (HP:0010582)1.93957455
126Exertional dyspnea (HP:0002875)1.93413680
127Gait imbalance (HP:0002141)1.92880921
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92723203
1293-Methylglutaconic aciduria (HP:0003535)1.92062767
130Nephrogenic diabetes insipidus (HP:0009806)1.91311602
131Multiple enchondromatosis (HP:0005701)1.91112269
132Glossoptosis (HP:0000162)1.90119579
133Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89179938
134Facial cleft (HP:0002006)1.88711770
135Progressive macrocephaly (HP:0004481)1.86985405
136Squamous cell carcinoma (HP:0002860)1.85293607
137Increased muscle lipid content (HP:0009058)1.85237748
138Abnormality of the astrocytes (HP:0100707)1.85057252
139Astrocytoma (HP:0009592)1.85057252
140Megaloblastic anemia (HP:0001889)1.84971256
141Glioma (HP:0009733)1.84932397
142Embryonal renal neoplasm (HP:0011794)1.84341291
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.82797731
144Abnormality of the vitamin B12 metabolism (HP:0004341)1.82050585
145Posterior subcapsular cataract (HP:0007787)1.81703457
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.81593419
147Cleft eyelid (HP:0000625)1.81540290
148Neoplasm of the oral cavity (HP:0100649)1.80091052
149Generalized aminoaciduria (HP:0002909)1.79505056
150Abnormality of the carotid arteries (HP:0005344)1.79009967
151Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78735263
152Abnormality of vitamin B metabolism (HP:0004340)1.77875839
153Abnormality of the renal collecting system (HP:0004742)1.77224990
154Hyperinsulinemic hypoglycemia (HP:0000825)1.76985335
155CNS demyelination (HP:0007305)1.76278008
156Pendular nystagmus (HP:0012043)1.74040086
157Stenosis of the external auditory canal (HP:0000402)1.73396319
158Hypoglycemic coma (HP:0001325)1.71844185
159Abolished electroretinogram (ERG) (HP:0000550)1.71715326
160Shoulder girdle muscle weakness (HP:0003547)1.69723757
161Muscle fiber inclusion bodies (HP:0100299)1.68582895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.47638206
2CDC74.36444821
3BUB14.30901912
4EIF2AK13.63609642
5TSSK63.53807732
6SRPK13.17084691
7NEK12.79303675
8STK162.78515808
9MKNK12.47895123
10MAP4K22.44853361
11EIF2AK32.40224282
12TRIM282.36948268
13PLK42.30001772
14VRK12.24638446
15VRK22.20837324
16TTK2.19569111
17TNIK2.16189978
18WNK32.10493450
19PNCK2.06508073
20PLK32.05063918
21NEK22.01276352
22BRSK22.00545839
23MKNK21.95608052
24PLK11.90913735
25ACVR1B1.79156859
26ATR1.69152992
27NUAK11.67530905
28CCNB11.61987385
29NME21.59627624
30PASK1.57403076
31AURKB1.54239710
32RPS6KB21.47566382
33CDK71.39947950
34TLK11.37900437
35AURKA1.30390435
36BRSK11.29025693
37NME11.28147009
38SCYL21.27070880
39CHEK11.24113833
40TESK21.22034362
41CHEK21.21013001
42DYRK31.12713779
43OBSCN1.10254734
44BMPR1B1.08001766
45CDK81.06238134
46BCKDK0.98589966
47TGFBR10.98295799
48MAP3K80.98217810
49PINK10.98198773
50PAK40.93469630
51CSNK1G10.92956820
52ATM0.92825286
53CDK40.92079997
54TAF10.90825524
55MST40.90740800
56CSNK2A20.90392242
57CSNK1G20.90190033
58STK38L0.89967860
59MAP3K40.88544658
60PDK40.84760744
61PDK30.84760744
62EPHA20.84425738
63ZAK0.82853109
64CDK20.82324176
65RPS6KA40.81570096
66CSNK2A10.77389509
67MUSK0.76799716
68MAP3K120.76421755
69CDK190.74662607
70DAPK10.72622636
71PBK0.70689483
72PLK20.70542643
73EIF2AK20.68853629
74CDK10.68364669
75STK40.67895518
76BRAF0.64986794
77STK100.64954352
78ALK0.64670516
79GRK10.64042796
80BRD40.62575920
81WNK40.59171760
82EEF2K0.58067662
83STK30.57810063
84STK390.56121191
85CSNK1A1L0.54011687
86FLT30.52761360
87PHKG20.52730433
88PHKG10.52730433
89PAK10.52456407
90CSNK1E0.51741265
91PRKCI0.50751159
92PRKCG0.50579673
93PIM20.50135734
94PIM10.47374926
95AKT30.46813970
96RPS6KA50.45875382
97PDK20.45688679
98ADRBK20.45173804
99PRKDC0.44442866
100CDK120.44313883
101MINK10.43380463
102STK240.42331825
103OXSR10.41729579
104MELK0.40749735
105LIMK10.40397036
106CASK0.37479323
107YES10.37206403
108CSNK1G30.36711483
109SIK30.36511245
110TAOK30.36112836
111RPS6KB10.35751503
112TESK10.34022432
113MAP2K70.33989828
114ERBB30.31733416
115AKT20.30755580
116CSNK1A10.30667625
117PRKACB0.27660986
118PAK30.27314877
119MAPK130.26529567
120ERBB40.26328794
121LRRK20.26001733
122CDK11A0.24889752
123CDK180.24842396
124INSRR0.23969562
125RAF10.23841528
126TEC0.23535052
127CDK60.23409994
128FGFR10.23255626
129BCR0.22976811
130MAPK140.22946651
131CLK10.22357648
132MAPKAPK30.21348994
133CSNK1D0.21230893
134CDK150.21115602
135DYRK20.20995043
136TAOK20.20576150
137CDK140.19339629

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77596183
2Mismatch repair_Homo sapiens_hsa034304.31658347
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08318909
4Proteasome_Homo sapiens_hsa030503.93172270
5RNA polymerase_Homo sapiens_hsa030203.77924952
6Ribosome_Homo sapiens_hsa030103.76749452
7Spliceosome_Homo sapiens_hsa030403.68053334
8RNA transport_Homo sapiens_hsa030133.35782235
9Homologous recombination_Homo sapiens_hsa034403.05290270
10Nucleotide excision repair_Homo sapiens_hsa034202.98645897
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92202297
12Base excision repair_Homo sapiens_hsa034102.77282899
13Pyrimidine metabolism_Homo sapiens_hsa002402.59979809
14One carbon pool by folate_Homo sapiens_hsa006702.58422903
15Cell cycle_Homo sapiens_hsa041102.53566767
16Non-homologous end-joining_Homo sapiens_hsa034502.39444222
17Fanconi anemia pathway_Homo sapiens_hsa034602.31010679
18RNA degradation_Homo sapiens_hsa030182.12067550
19Basal transcription factors_Homo sapiens_hsa030222.07701765
20Propanoate metabolism_Homo sapiens_hsa006402.03224637
21mRNA surveillance pathway_Homo sapiens_hsa030151.83214842
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81630597
23Fatty acid elongation_Homo sapiens_hsa000621.63442693
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60173827
25Purine metabolism_Homo sapiens_hsa002301.54164891
26Steroid biosynthesis_Homo sapiens_hsa001001.33317349
27Parkinsons disease_Homo sapiens_hsa050121.29807813
28Oxidative phosphorylation_Homo sapiens_hsa001901.26216774
29Huntingtons disease_Homo sapiens_hsa050161.21615184
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21223803
31p53 signaling pathway_Homo sapiens_hsa041151.18303904
32Epstein-Barr virus infection_Homo sapiens_hsa051691.14433972
33Protein export_Homo sapiens_hsa030601.13705328
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.12856477
35Oocyte meiosis_Homo sapiens_hsa041141.08558697
36Butanoate metabolism_Homo sapiens_hsa006501.07883449
37Systemic lupus erythematosus_Homo sapiens_hsa053221.04907302
38Peroxisome_Homo sapiens_hsa041461.00335029
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91678434
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91199287
41Biosynthesis of amino acids_Homo sapiens_hsa012300.90383744
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89806259
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86930901
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78991211
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77394404
46Fatty acid degradation_Homo sapiens_hsa000710.77086333
47Fatty acid metabolism_Homo sapiens_hsa012120.74831014
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.73853106
49Pentose phosphate pathway_Homo sapiens_hsa000300.71871666
50Viral carcinogenesis_Homo sapiens_hsa052030.71740381
51Caffeine metabolism_Homo sapiens_hsa002320.71685729
52Vitamin B6 metabolism_Homo sapiens_hsa007500.69042146
53Tryptophan metabolism_Homo sapiens_hsa003800.67693879
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67371347
55Sulfur metabolism_Homo sapiens_hsa009200.65112462
56beta-Alanine metabolism_Homo sapiens_hsa004100.62363220
57Alzheimers disease_Homo sapiens_hsa050100.61818773
58Antigen processing and presentation_Homo sapiens_hsa046120.61534288
59Regulation of autophagy_Homo sapiens_hsa041400.61434056
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.61371296
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60859192
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.60418526
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60134980
64Alcoholism_Homo sapiens_hsa050340.57563582
65Carbon metabolism_Homo sapiens_hsa012000.57110588
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56103704
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54661388
68Herpes simplex infection_Homo sapiens_hsa051680.53380084
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52565606
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49425750
71Retinol metabolism_Homo sapiens_hsa008300.48997874
72Selenocompound metabolism_Homo sapiens_hsa004500.47632924
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44639724
74Phototransduction_Homo sapiens_hsa047440.43680771
75Thyroid cancer_Homo sapiens_hsa052160.43225239
76HTLV-I infection_Homo sapiens_hsa051660.42111160
77Glutathione metabolism_Homo sapiens_hsa004800.41950628
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41890767
79Chemical carcinogenesis_Homo sapiens_hsa052040.41472575
80Folate biosynthesis_Homo sapiens_hsa007900.40529530
81Nitrogen metabolism_Homo sapiens_hsa009100.39640436
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39398662
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38919764
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36460081
85Legionellosis_Homo sapiens_hsa051340.34849623
86Metabolic pathways_Homo sapiens_hsa011000.33053466
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32320209
88Vitamin digestion and absorption_Homo sapiens_hsa049770.31940666
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.31490961
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31406106
91Fat digestion and absorption_Homo sapiens_hsa049750.31273204
92N-Glycan biosynthesis_Homo sapiens_hsa005100.29343200
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28737296
94Linoleic acid metabolism_Homo sapiens_hsa005910.28260065
95Fructose and mannose metabolism_Homo sapiens_hsa000510.27918246
96MicroRNAs in cancer_Homo sapiens_hsa052060.27396084
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26720555
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25697955
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24554482
100Colorectal cancer_Homo sapiens_hsa052100.23976560
101TGF-beta signaling pathway_Homo sapiens_hsa043500.23841366
102Arginine biosynthesis_Homo sapiens_hsa002200.23775652
103Ether lipid metabolism_Homo sapiens_hsa005650.20787517
104Pyruvate metabolism_Homo sapiens_hsa006200.20749407
105Type I diabetes mellitus_Homo sapiens_hsa049400.20340493
106Starch and sucrose metabolism_Homo sapiens_hsa005000.19620144
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17846901
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.17714857
109Tyrosine metabolism_Homo sapiens_hsa003500.17157015
110Sulfur relay system_Homo sapiens_hsa041220.15784514
111Circadian rhythm_Homo sapiens_hsa047100.13734018
112Small cell lung cancer_Homo sapiens_hsa052220.13006558
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12974979
114Hippo signaling pathway_Homo sapiens_hsa043900.11508805
115HIF-1 signaling pathway_Homo sapiens_hsa040660.11307043
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11303396
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.09055052
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07222950
119Basal cell carcinoma_Homo sapiens_hsa052170.07151521
120Cardiac muscle contraction_Homo sapiens_hsa042600.05446135
121Vibrio cholerae infection_Homo sapiens_hsa051100.05243817
122Pathways in cancer_Homo sapiens_hsa052000.03901653
123Shigellosis_Homo sapiens_hsa051310.03762289
124Renin-angiotensin system_Homo sapiens_hsa046140.02714405
125Hepatitis B_Homo sapiens_hsa051610.02518278
126Galactose metabolism_Homo sapiens_hsa000520.02191841
127Wnt signaling pathway_Homo sapiens_hsa043100.01349059
128Melanoma_Homo sapiens_hsa052180.01136967
129Apoptosis_Homo sapiens_hsa042100.00921893
130Collecting duct acid secretion_Homo sapiens_hsa04966-0.0578013
131Bladder cancer_Homo sapiens_hsa05219-0.0538500
132PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0491300
133Arginine and proline metabolism_Homo sapiens_hsa00330-0.0410819
134Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0381273
135Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0370192
136Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0196609
137Asthma_Homo sapiens_hsa05310-0.0062150

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