PPIE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.12840345
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.11802460
3DNA deamination (GO:0045006)4.90634019
4protein complex biogenesis (GO:0070271)4.86785132
5maturation of SSU-rRNA (GO:0030490)4.82942530
6viral transcription (GO:0019083)4.78506518
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74808847
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.74808847
9NADH dehydrogenase complex assembly (GO:0010257)4.74808847
10DNA strand elongation involved in DNA replication (GO:0006271)4.68782580
11translational termination (GO:0006415)4.64122924
12ribosomal small subunit biogenesis (GO:0042274)4.63350840
13mitochondrial respiratory chain complex assembly (GO:0033108)4.62239625
14telomere maintenance via semi-conservative replication (GO:0032201)4.62229695
15DNA strand elongation (GO:0022616)4.58735655
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55757879
17ATP synthesis coupled proton transport (GO:0015986)4.55757879
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49721754
19formation of translation preinitiation complex (GO:0001731)4.32772993
20translational elongation (GO:0006414)4.25091588
21ribosomal large subunit biogenesis (GO:0042273)4.23785400
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.20148723
23telomere maintenance via recombination (GO:0000722)4.17003397
24proteasome assembly (GO:0043248)4.16930311
25nucleobase biosynthetic process (GO:0046112)4.15713782
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.13850627
27cotranslational protein targeting to membrane (GO:0006613)4.10296386
28DNA replication initiation (GO:0006270)4.09049801
29protein targeting to ER (GO:0045047)4.07292757
30respiratory electron transport chain (GO:0022904)4.01385927
31respiratory chain complex IV assembly (GO:0008535)4.01039174
32electron transport chain (GO:0022900)3.98607984
33translational initiation (GO:0006413)3.95133614
34cytochrome complex assembly (GO:0017004)3.92926515
35ribonucleoprotein complex biogenesis (GO:0022613)3.92195201
36purine nucleobase biosynthetic process (GO:0009113)3.89067903
37protein localization to endoplasmic reticulum (GO:0070972)3.86870681
38mitotic recombination (GO:0006312)3.85323598
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.83786665
40telomere maintenance via telomere lengthening (GO:0010833)3.83196358
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77072628
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75255219
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73889362
44DNA replication checkpoint (GO:0000076)3.70473858
45viral life cycle (GO:0019058)3.66461077
46CENP-A containing nucleosome assembly (GO:0034080)3.65575347
47cellular protein complex disassembly (GO:0043624)3.63280531
48chaperone-mediated protein transport (GO:0072321)3.61283316
49regulation of mitochondrial translation (GO:0070129)3.61240390
50DNA unwinding involved in DNA replication (GO:0006268)3.60477025
51ribosome biogenesis (GO:0042254)3.59459800
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59028105
53mitotic metaphase plate congression (GO:0007080)3.58652762
54IMP biosynthetic process (GO:0006188)3.58307233
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57788236
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.57609353
57rRNA processing (GO:0006364)3.51346507
58pseudouridine synthesis (GO:0001522)3.49980107
59chromatin remodeling at centromere (GO:0031055)3.49927556
60transcription-coupled nucleotide-excision repair (GO:0006283)3.49644918
61water-soluble vitamin biosynthetic process (GO:0042364)3.48438084
62negative regulation of ligase activity (GO:0051352)3.46046322
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46046322
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.45703065
65termination of RNA polymerase III transcription (GO:0006386)3.44915531
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.44915531
67translation (GO:0006412)3.44651707
68protein localization to kinetochore (GO:0034501)3.40762741
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39971426
70spliceosomal snRNP assembly (GO:0000387)3.38564035
71rRNA metabolic process (GO:0016072)3.37920479
72DNA double-strand break processing (GO:0000729)3.37545886
73rRNA methylation (GO:0031167)3.36883917
74protein neddylation (GO:0045116)3.35961361
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.35443835
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34687519
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34687519
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33879596
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33879596
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33879596
81protein targeting to mitochondrion (GO:0006626)3.29511318
82rRNA modification (GO:0000154)3.29088288
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.27642789
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27642789
85resolution of meiotic recombination intermediates (GO:0000712)3.27642640
86peptidyl-histidine modification (GO:0018202)3.26310858
87synapsis (GO:0007129)3.26215448
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24615235
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.22800865
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22483950
91regulation of cellular amino acid metabolic process (GO:0006521)3.22373961
927-methylguanosine mRNA capping (GO:0006370)3.22121443
93protein complex disassembly (GO:0043241)3.22064302
94cellular component biogenesis (GO:0044085)3.18752799
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17486811
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17486811
97metaphase plate congression (GO:0051310)3.17312979
98viral mRNA export from host cell nucleus (GO:0046784)3.16410225
997-methylguanosine RNA capping (GO:0009452)3.16142284
100RNA capping (GO:0036260)3.16142284
101nuclear-transcribed mRNA catabolic process (GO:0000956)3.14785245
102ribosome assembly (GO:0042255)3.14681355
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13507558
104G1/S transition of mitotic cell cycle (GO:0000082)3.13328070
105cell cycle G1/S phase transition (GO:0044843)3.13328070
106DNA replication-independent nucleosome organization (GO:0034724)3.13315855
107DNA replication-independent nucleosome assembly (GO:0006336)3.13315855
108establishment of protein localization to mitochondrion (GO:0072655)3.13275336
109IMP metabolic process (GO:0046040)3.12382207
110replication fork processing (GO:0031297)3.12324351
111ubiquinone biosynthetic process (GO:0006744)3.08036313
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06718654
113oxidative phosphorylation (GO:0006119)3.06526611
114antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.06192814
115kinetochore organization (GO:0051383)3.05844560
116macromolecular complex disassembly (GO:0032984)3.05342532
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04372156
118protein localization to mitochondrion (GO:0070585)3.00505680
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.99503365
120mRNA catabolic process (GO:0006402)2.99465987
121positive regulation of ligase activity (GO:0051351)2.95786822
122termination of RNA polymerase I transcription (GO:0006363)2.95744281
123DNA catabolic process, exonucleolytic (GO:0000738)2.95150218
124mitotic nuclear envelope disassembly (GO:0007077)2.94679085
125kinetochore assembly (GO:0051382)2.93004254
126protein K6-linked ubiquitination (GO:0085020)2.92729537
127cullin deneddylation (GO:0010388)2.91677651
128RNA catabolic process (GO:0006401)2.91668913
129mannosylation (GO:0097502)2.91064900
130establishment of chromosome localization (GO:0051303)2.90420979
131meiotic chromosome segregation (GO:0045132)2.90245574
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90188354
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.90188354
134transcription from RNA polymerase I promoter (GO:0006360)2.90071898
135preassembly of GPI anchor in ER membrane (GO:0016254)2.89274768
136protein localization to chromosome, centromeric region (GO:0071459)2.89194691
137maturation of 5.8S rRNA (GO:0000460)2.89089988
138telomere organization (GO:0032200)2.88720212
139telomere maintenance (GO:0000723)2.88076450
140intracellular protein transmembrane import (GO:0044743)2.86951991
141DNA replication-dependent nucleosome organization (GO:0034723)2.84389888
142DNA replication-dependent nucleosome assembly (GO:0006335)2.84389888
143recombinational repair (GO:0000725)2.81194434
144tRNA processing (GO:0008033)2.80944744
145protein deneddylation (GO:0000338)2.80508837
146amino acid salvage (GO:0043102)2.80187569
147L-methionine salvage (GO:0071267)2.80187569
148L-methionine biosynthetic process (GO:0071265)2.80187569
149ubiquinone metabolic process (GO:0006743)2.77416575
150protein-cofactor linkage (GO:0018065)2.77085942
151mitochondrial RNA metabolic process (GO:0000959)2.77033860
152double-strand break repair via homologous recombination (GO:0000724)2.76602918
153protein polyglutamylation (GO:0018095)2.75532778
154purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72204987
155ATP biosynthetic process (GO:0006754)2.67719102
156negative regulation of telomere maintenance (GO:0032205)2.66847324
157iron-sulfur cluster assembly (GO:0016226)2.66658362
158metallo-sulfur cluster assembly (GO:0031163)2.66658362
159purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66595314
160hydrogen ion transmembrane transport (GO:1902600)2.65185450
161transcription from mitochondrial promoter (GO:0006390)2.63522532
162inner mitochondrial membrane organization (GO:0007007)2.63342797
163GTP biosynthetic process (GO:0006183)2.63036654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13580538
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.26580304
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83864120
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54701844
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.36371827
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.22494838
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17154105
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11326980
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.08454844
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97885921
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94736381
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88328201
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85723201
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79508380
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75442665
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75154430
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70185718
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.69471224
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64271262
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60089557
21VDR_23849224_ChIP-Seq_CD4+_Human2.46211127
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36014239
23XRN2_22483619_ChIP-Seq_HELA_Human2.34658096
24ZNF274_21170338_ChIP-Seq_K562_Hela2.29910977
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25232376
26FOXP3_21729870_ChIP-Seq_TREG_Human2.18221726
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14763647
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13776055
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12302315
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09931957
31DCP1A_22483619_ChIP-Seq_HELA_Human2.05034370
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95468550
33GABP_19822575_ChIP-Seq_HepG2_Human1.95195408
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87739493
35TTF2_22483619_ChIP-Seq_HELA_Human1.86409664
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.82316218
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81572947
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79627722
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79596687
40* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76127714
41ELK1_19687146_ChIP-ChIP_HELA_Human1.75261150
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73543529
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69072078
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68321614
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.67668165
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67599066
47* AR_21909140_ChIP-Seq_LNCAP_Human1.67080573
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65745978
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64661483
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.62198690
51CIITA_25753668_ChIP-Seq_RAJI_Human1.60993436
52VDR_22108803_ChIP-Seq_LS180_Human1.55052937
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51736047
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50073000
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48014623
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46423488
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46275985
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41612721
59EWS_26573619_Chip-Seq_HEK293_Human1.38079267
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38018576
61MYC_22102868_ChIP-Seq_BL_Human1.34844868
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32604188
63IRF1_19129219_ChIP-ChIP_H3396_Human1.31299347
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.31018637
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30862115
66* KDM5A_27292631_Chip-Seq_BREAST_Human1.25947809
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24788485
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24135540
69TP53_22573176_ChIP-Seq_HFKS_Human1.21707567
70SPI1_23547873_ChIP-Seq_NB4_Human1.21149454
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17287894
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14937025
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.14713001
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14479225
75IGF1R_20145208_ChIP-Seq_DFB_Human1.13248180
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12297719
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11042179
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10141346
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06091810
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.05853936
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05676654
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04772136
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04001101
84TFEB_21752829_ChIP-Seq_HELA_Human1.03974616
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03906678
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03737137
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.03486488
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03168933
89FUS_26573619_Chip-Seq_HEK293_Human1.02832796
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02151252
91MYC_18940864_ChIP-ChIP_HL60_Human1.00253138
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99950532
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97561797
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96275086
95NCOR_22424771_ChIP-Seq_293T_Human0.95817446
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94829776
97* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94753838
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94382552
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94363231
100VDR_21846776_ChIP-Seq_THP-1_Human0.93373461
101AR_20517297_ChIP-Seq_VCAP_Human0.93109178
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91891341
103FOXA1_25329375_ChIP-Seq_VCAP_Human0.91836032
104FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91836032
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91548550
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91322226
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88560371
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.87226818
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.87130266
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84952452
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84660466
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84309561
113SCL_19346495_ChIP-Seq_HPC-7_Human0.82246690
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81832147
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80142100
116GATA3_21878914_ChIP-Seq_MCF-7_Human0.79179019
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78889383
118ERG_20517297_ChIP-Seq_VCAP_Human0.78830784
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78028072
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77867549
121SOX2_19829295_ChIP-Seq_ESCs_Human0.77210218
122NANOG_19829295_ChIP-Seq_ESCs_Human0.77210218
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75731217
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75664010
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75472796
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74618729
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74036532
128* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73985950
129NANOG_20526341_ChIP-Seq_ESCs_Human0.73971507
130* GATA6_21074721_ChIP-Seq_CACO-2_Human0.72009983
131* RBPJ_21746931_ChIP-Seq_IB4_Human0.71458183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06717135
2MP0010094_abnormal_chromosome_stability4.27174604
3MP0004957_abnormal_blastocyst_morpholog4.12207583
4MP0003111_abnormal_nucleus_morphology3.97568792
5MP0003077_abnormal_cell_cycle3.69782720
6MP0008058_abnormal_DNA_repair3.34267555
7MP0008057_abnormal_DNA_replication3.31102090
8MP0002396_abnormal_hematopoietic_system3.06698116
9MP0008007_abnormal_cellular_replicative2.92847927
10MP0002837_dystrophic_cardiac_calcinosis2.63527955
11MP0008995_early_reproductive_senescence2.50123821
12MP0008932_abnormal_embryonic_tissue2.32283102
13MP0003763_abnormal_thymus_physiology2.19849620
14MP0002163_abnormal_gland_morphology2.11659109
15MP0003786_premature_aging2.08475471
16MP0000490_abnormal_crypts_of2.02461864
17MP0005084_abnormal_gallbladder_morpholo1.99555327
18MP0008872_abnormal_physiological_respon1.94221657
19MP0009379_abnormal_foot_pigmentation1.89606647
20MP0004808_abnormal_hematopoietic_stem1.86609152
21MP0003806_abnormal_nucleotide_metabolis1.86157524
22MP0002102_abnormal_ear_morphology1.78803592
23MP0005075_abnormal_melanosome_morpholog1.78371100
24MP0001730_embryonic_growth_arrest1.77147783
25MP0009333_abnormal_splenocyte_physiolog1.77126456
26MP0006072_abnormal_retinal_apoptosis1.75581562
27MP0005397_hematopoietic_system_phenotyp1.74438046
28MP0001545_abnormal_hematopoietic_system1.74438046
29MP0001835_abnormal_antigen_presentation1.71038844
30MP0000350_abnormal_cell_proliferation1.70501551
31MP0003123_paternal_imprinting1.69115015
32MP0005646_abnormal_pituitary_gland1.65302162
33MP0002138_abnormal_hepatobiliary_system1.61296510
34MP0005551_abnormal_eye_electrophysiolog1.60685279
35MP0005083_abnormal_biliary_tract1.57951152
36MP0003186_abnormal_redox_activity1.56982016
37MP0003718_maternal_effect1.56606758
38MP0002019_abnormal_tumor_incidence1.55022994
39MP0002398_abnormal_bone_marrow1.53689926
40MP0002722_abnormal_immune_system1.43439954
41MP0005379_endocrine/exocrine_gland_phen1.42558551
42MP0002876_abnormal_thyroid_physiology1.42270253
43MP0001968_abnormal_touch/_nociception1.41539166
44MP0000313_abnormal_cell_death1.40492408
45MP0005671_abnormal_response_to1.40239127
46MP0000689_abnormal_spleen_morphology1.39668853
47MP0004142_abnormal_muscle_tone1.36424267
48MP0003787_abnormal_imprinting1.35654296
49MP0001853_heart_inflammation1.35372389
50MP0006292_abnormal_olfactory_placode1.33670471
51MP0005645_abnormal_hypothalamus_physiol1.33585461
52MP0000703_abnormal_thymus_morphology1.32322962
53MP0002132_abnormal_respiratory_system1.30264848
54MP0005253_abnormal_eye_physiology1.26961294
55MP0001905_abnormal_dopamine_level1.26177756
56MP0000465_gastrointestinal_hemorrhage1.25991365
57MP0001697_abnormal_embryo_size1.25027415
58MP0002080_prenatal_lethality1.24918645
59MP0000015_abnormal_ear_pigmentation1.24075629
60MP0002736_abnormal_nociception_after1.24068787
61MP0000516_abnormal_urinary_system1.23587476
62MP0005367_renal/urinary_system_phenotyp1.23587476
63MP0002095_abnormal_skin_pigmentation1.23358581
64MP0009785_altered_susceptibility_to1.22822099
65MP0002429_abnormal_blood_cell1.22682663
66MP0002638_abnormal_pupillary_reflex1.21790316
67MP0003195_calcinosis1.21527556
68MP0006054_spinal_hemorrhage1.21308251
69MP0010352_gastrointestinal_tract_polyps1.20800665
70MP0005410_abnormal_fertilization1.19636054
71MP0003567_abnormal_fetal_cardiomyocyte1.16169864
72MP0005380_embryogenesis_phenotype1.16122258
73MP0001672_abnormal_embryogenesis/_devel1.16122258
74MP0008877_abnormal_DNA_methylation1.15912793
75MP0001800_abnormal_humoral_immune1.14968711
76MP0000716_abnormal_immune_system1.14783768
77MP0005174_abnormal_tail_pigmentation1.12276721
78MP0003011_delayed_dark_adaptation1.12026346
79MP0002420_abnormal_adaptive_immunity1.10835283
80MP0001819_abnormal_immune_cell1.08858401
81MP0000685_abnormal_immune_system1.08541441
82MP0006036_abnormal_mitochondrial_physio1.07909921
83MP0002148_abnormal_hypersensitivity_rea1.07478505
84MP0003646_muscle_fatigue1.07426280
85MP0002452_abnormal_antigen_presenting1.06757113
86MP0003984_embryonic_growth_retardation1.05669662
87MP0000858_altered_metastatic_potential1.04632184
88MP0003315_abnormal_perineum_morphology1.03895575
89MP0000631_abnormal_neuroendocrine_gland1.01555651
90MP0002088_abnormal_embryonic_growth/wei1.01493169
91MP0005025_abnormal_response_to1.00382690
92MP0001529_abnormal_vocalization1.00185179
93MP0009046_muscle_twitch0.98495580
94MP0001661_extended_life_span0.98201954
95MP0001764_abnormal_homeostasis0.97698110
96MP0002723_abnormal_immune_serum0.97379556
97MP0002277_abnormal_respiratory_mucosa0.97048461
98MP0001485_abnormal_pinna_reflex0.96485671
99MP0003698_abnormal_male_reproductive0.96466404
100MP0005464_abnormal_platelet_physiology0.94836125
101MP0002210_abnormal_sex_determination0.94184109
102MP0010030_abnormal_orbit_morphology0.91447874
103MP0004147_increased_porphyrin_level0.91418438
104MP0005636_abnormal_mineral_homeostasis0.91008593
105MP0002086_abnormal_extraembryonic_tissu0.90898781
106MP0005332_abnormal_amino_acid0.90645341
107MP0010307_abnormal_tumor_latency0.90174445
108MP0005000_abnormal_immune_tolerance0.89551733
109MP0002405_respiratory_system_inflammati0.88253938
110MP0001986_abnormal_taste_sensitivity0.87752067
111MP0002085_abnormal_embryonic_tissue0.87310143
112MP0010155_abnormal_intestine_physiology0.86912206
113MP0002653_abnormal_ependyma_morphology0.86730080
114MP0008875_abnormal_xenobiotic_pharmacok0.84829812
115MP0008789_abnormal_olfactory_epithelium0.84599965
116MP0000358_abnormal_cell_content/0.84555294
117MP0009697_abnormal_copulation0.82625649
118MP0002166_altered_tumor_susceptibility0.82555913
119MP0000613_abnormal_salivary_gland0.82183632
120MP0003943_abnormal_hepatobiliary_system0.82134188
121MP0001119_abnormal_female_reproductive0.81752845
122MP0001145_abnormal_male_reproductive0.81302639
123MP0006035_abnormal_mitochondrial_morpho0.80952483
124MP0005389_reproductive_system_phenotype0.80721028
125MP0000049_abnormal_middle_ear0.79826109
126MP0003436_decreased_susceptibility_to0.79378087
127MP0002006_tumorigenesis0.77808660
128MP0002160_abnormal_reproductive_system0.77132792
129MP0000372_irregular_coat_pigmentation0.76905829
130MP0003724_increased_susceptibility_to0.75844205
131MP0004145_abnormal_muscle_electrophysio0.74861759
132MP0001919_abnormal_reproductive_system0.74843921
133MP0001293_anophthalmia0.74131409
134MP0002928_abnormal_bile_duct0.74007164
135MP0005023_abnormal_wound_healing0.73153796
136MP0002938_white_spotting0.72835834
137MP0006276_abnormal_autonomic_nervous0.72443949
138MP0004197_abnormal_fetal_growth/weight/0.71462698
139MP0001984_abnormal_olfaction0.70910424
140MP0002084_abnormal_developmental_patter0.70330911
141MP0002234_abnormal_pharynx_morphology0.69504306
142MP0000653_abnormal_sex_gland0.69440088
143MP0003866_abnormal_defecation0.68468411
144MP0004134_abnormal_chest_morphology0.68468163
145MP0000477_abnormal_intestine_morphology0.68069097
146MP0001873_stomach_inflammation0.65679884
147MP0004043_abnormal_pH_regulation0.64996516
148MP0001929_abnormal_gametogenesis0.64453115
149MP0005220_abnormal_exocrine_pancreas0.64445881
150MP0002693_abnormal_pancreas_physiology0.62338188
151MP0002139_abnormal_hepatobiliary_system0.62275465
152MP0005187_abnormal_penis_morphology0.61293304
153MP0002735_abnormal_chemical_nociception0.61121181
154MP0005266_abnormal_metabolism0.61115703
155MP0008873_increased_physiological_sensi0.60935072
156MP0002751_abnormal_autonomic_nervous0.59398301
157MP0009745_abnormal_behavioral_response0.59146552

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.54379867
2Abnormal number of erythroid precursors (HP:0012131)5.35138892
3Reticulocytopenia (HP:0001896)4.87007689
4Birth length less than 3rd percentile (HP:0003561)4.61728914
5Abnormal mitochondria in muscle tissue (HP:0008316)4.35578107
6Acute encephalopathy (HP:0006846)4.17730922
7Progressive macrocephaly (HP:0004481)4.00860571
8Aplastic anemia (HP:0001915)3.93294922
9Macrocytic anemia (HP:0001972)3.40740639
10Oral leukoplakia (HP:0002745)3.40391944
11Pancreatic cysts (HP:0001737)3.31500972
12Rough bone trabeculation (HP:0100670)3.28687558
13Degeneration of anterior horn cells (HP:0002398)3.26197635
14Abnormality of the anterior horn cell (HP:0006802)3.26197635
15Pallor (HP:0000980)3.25391012
1611 pairs of ribs (HP:0000878)3.22256592
17Thrombocytosis (HP:0001894)3.17931104
18Pancreatic fibrosis (HP:0100732)3.15206603
19Cerebral edema (HP:0002181)3.13046106
20Type I transferrin isoform profile (HP:0003642)3.08276801
21Colon cancer (HP:0003003)3.01414371
22Breast hypoplasia (HP:0003187)2.98506379
23True hermaphroditism (HP:0010459)2.96981068
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93457392
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93457392
26Carpal bone hypoplasia (HP:0001498)2.92393741
27Lactic acidosis (HP:0003128)2.92258988
28Abnormality of midbrain morphology (HP:0002418)2.91985203
29Molar tooth sign on MRI (HP:0002419)2.91985203
30Renal Fanconi syndrome (HP:0001994)2.87429853
31IgM deficiency (HP:0002850)2.82713560
32Hepatocellular necrosis (HP:0001404)2.82121853
333-Methylglutaconic aciduria (HP:0003535)2.74617837
34Increased intramyocellular lipid droplets (HP:0012240)2.72781077
35Hepatic necrosis (HP:0002605)2.69967733
36Methylmalonic acidemia (HP:0002912)2.62225678
37Increased serum lactate (HP:0002151)2.61177168
38Patellar aplasia (HP:0006443)2.60948157
39Absent thumb (HP:0009777)2.59959970
40Premature graying of hair (HP:0002216)2.57377884
41Microretrognathia (HP:0000308)2.57263521
42Chromsome breakage (HP:0040012)2.55679043
43Selective tooth agenesis (HP:0001592)2.54769091
44Respiratory failure (HP:0002878)2.54258843
45Petechiae (HP:0000967)2.54008774
46Abnormality of the preputium (HP:0100587)2.53847287
47Muscle fiber atrophy (HP:0100295)2.53766527
48Myelodysplasia (HP:0002863)2.53712540
49Type 2 muscle fiber atrophy (HP:0003554)2.53366086
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51677433
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49485900
52Methylmalonic aciduria (HP:0012120)2.48527298
53Sparse eyelashes (HP:0000653)2.46641043
54Aplasia/Hypoplasia of the patella (HP:0006498)2.45351179
55Meckel diverticulum (HP:0002245)2.42483956
56Increased muscle lipid content (HP:0009058)2.42302342
57Cerebral hypomyelination (HP:0006808)2.40506785
58Optic disc pallor (HP:0000543)2.39332873
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37998616
60Abnormality of the ileum (HP:0001549)2.36715065
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35842180
62Bone marrow hypocellularity (HP:0005528)2.34787778
63Abnormal rod and cone electroretinograms (HP:0008323)2.34309797
64Abnormal trabecular bone morphology (HP:0100671)2.34106581
65Microvesicular hepatic steatosis (HP:0001414)2.33481604
66Exercise intolerance (HP:0003546)2.33430108
67Abolished electroretinogram (ERG) (HP:0000550)2.32887318
68Lethargy (HP:0001254)2.31134799
69Abnormality of DNA repair (HP:0003254)2.30208916
70Abnormal protein glycosylation (HP:0012346)2.28252090
71Abnormal glycosylation (HP:0012345)2.28252090
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28252090
73Abnormal protein N-linked glycosylation (HP:0012347)2.28252090
74Pancytopenia (HP:0001876)2.28021396
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22942987
76Medial flaring of the eyebrow (HP:0010747)2.22063408
77Nephronophthisis (HP:0000090)2.21968019
78Increased CSF lactate (HP:0002490)2.21396520
79Reduced antithrombin III activity (HP:0001976)2.20146855
80Irregular epiphyses (HP:0010582)2.19469508
81Lymphoma (HP:0002665)2.19434521
82Mitochondrial inheritance (HP:0001427)2.18893140
83Poor head control (HP:0002421)2.18792763
84Trismus (HP:0000211)2.17573784
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16549538
86Increased hepatocellular lipid droplets (HP:0006565)2.16084587
87Cellular immunodeficiency (HP:0005374)2.16046691
88Sclerocornea (HP:0000647)2.15823844
89Respiratory difficulties (HP:0002880)2.15192377
90Abnormality of chromosome stability (HP:0003220)2.11837697
91Pendular nystagmus (HP:0012043)2.11823778
92Exertional dyspnea (HP:0002875)2.08518131
93Neoplasm of the pancreas (HP:0002894)2.07527771
94Attenuation of retinal blood vessels (HP:0007843)2.07514877
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.07392410
96Multiple enchondromatosis (HP:0005701)2.07153819
97Dicarboxylic aciduria (HP:0003215)2.07149859
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07149859
99CNS demyelination (HP:0007305)2.06478925
100Abnormal lung lobation (HP:0002101)2.06003870
101Type II lissencephaly (HP:0007260)2.05828506
102Congenital stationary night blindness (HP:0007642)2.04669886
103Elevated erythrocyte sedimentation rate (HP:0003565)2.00950329
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00759842
105Abnormality of the pons (HP:0007361)2.00427850
106Agnosia (HP:0010524)2.00290812
107Cleft eyelid (HP:0000625)1.99612772
108Abnormality of alanine metabolism (HP:0010916)1.99376807
109Hyperalaninemia (HP:0003348)1.99376807
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99376807
111Hypoplasia of the pons (HP:0012110)1.98629868
112Glycosuria (HP:0003076)1.97436612
113Abnormality of urine glucose concentration (HP:0011016)1.97436612
114Leukodystrophy (HP:0002415)1.97379010
115Duodenal stenosis (HP:0100867)1.95963674
116Small intestinal stenosis (HP:0012848)1.95963674
117Renal cortical cysts (HP:0000803)1.94585115
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94067435
119Congenital, generalized hypertrichosis (HP:0004540)1.93007107
120Aplasia/hypoplasia of the uterus (HP:0008684)1.92532618
121IgG deficiency (HP:0004315)1.91719766
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.89430524
123Cerebellar dysplasia (HP:0007033)1.89391671
124Atrophy/Degeneration involving motor neurons (HP:0007373)1.89071610
125Abnormality of the renal cortex (HP:0011035)1.87728301
126Bile duct proliferation (HP:0001408)1.87153040
127Abnormal biliary tract physiology (HP:0012439)1.87153040
128Triphalangeal thumb (HP:0001199)1.86024194
129Severe combined immunodeficiency (HP:0004430)1.85740131
130Glossoptosis (HP:0000162)1.85043911
131Abnormality of T cell physiology (HP:0011840)1.84605869
132Lipid accumulation in hepatocytes (HP:0006561)1.83649935
133Hypoplasia of the uterus (HP:0000013)1.82784585
134Horseshoe kidney (HP:0000085)1.82752018
135Male pseudohermaphroditism (HP:0000037)1.82520825
136Progressive muscle weakness (HP:0003323)1.82047855
137Medulloblastoma (HP:0002885)1.81877893
138Amaurosis fugax (HP:0100576)1.81414861
139Cystic liver disease (HP:0006706)1.81143025
140Abnormality of the renal collecting system (HP:0004742)1.79724003
141Hypothermia (HP:0002045)1.77821617
142Tracheoesophageal fistula (HP:0002575)1.76706864
143Abnormality of renal resorption (HP:0011038)1.75370916
144Self-mutilation (HP:0000742)1.74165244
145Progressive microcephaly (HP:0000253)1.73426286
146Acute necrotizing encephalopathy (HP:0006965)1.73226733
147Impulsivity (HP:0100710)1.73087088
148Secondary amenorrhea (HP:0000869)1.73005492
149Supernumerary spleens (HP:0009799)1.71851739
150Absent epiphyses (HP:0010577)1.71050772
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71050772
152Sloping forehead (HP:0000340)1.69986669
153Hypoplasia of the radius (HP:0002984)1.69851722
154Duplicated collecting system (HP:0000081)1.69778056
155Entropion (HP:0000621)1.69347842
156Asplenia (HP:0001746)1.69060244
157Abnormality of glycolysis (HP:0004366)1.69057096
158Furrowed tongue (HP:0000221)1.68845722
159Emotional lability (HP:0000712)1.68180818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.93754238
2VRK24.34313177
3WEE13.89171508
4NME23.49325678
5EIF2AK13.12410298
6STK163.06595754
7FRK3.05958156
8NUAK12.93436768
9CDC72.58736864
10TSSK62.51218424
11GRK12.40277430
12SRPK12.40080101
13VRK12.28292300
14MKNK12.12019029
15MAP4K22.05308528
16EIF2AK32.05088548
17BCKDK1.90293669
18PLK41.85056209
19NEK21.84948938
20PASK1.84465839
21BMPR1B1.84462911
22RPS6KB21.80224536
23BRSK21.74922113
24ACVR1B1.74596732
25RPS6KA41.69989320
26PIM21.69405582
27WNK31.67580021
28KDR1.65442818
29PLK11.52775070
30CCNB11.51988890
31TGFBR11.51022034
32TESK21.48153614
33ATR1.43509648
34DYRK31.42648643
35TTK1.41284039
36MAP4K11.39893824
37TLK11.39461753
38AURKB1.39145679
39CDK71.37118191
40PINK11.36701732
41TAOK31.36657478
42TRIM281.27791303
43CSNK1G31.23123709
44NEK11.20431495
45EPHA21.18263139
46BTK1.17838528
47DYRK21.15316079
48PLK31.14576430
49BRSK11.13931775
50STK101.08759546
51INSRR1.07650220
52CDK81.06690886
53ZAK1.05138025
54PDK21.03085018
55MKNK21.02107128
56AURKA1.01343631
57MAP3K31.01217890
58CSNK1G11.00482879
59CSNK1A1L1.00293392
60MAPK130.99536753
61CSNK1G20.98417637
62EEF2K0.98364166
63KIT0.97296222
64MAP3K80.95842157
65TYK20.94697403
66PIM10.94591917
67TEC0.92073672
68CDK40.92024579
69TXK0.91835334
70MARK30.91533008
71PAK40.89028738
72NME10.88104455
73ZAP700.85735082
74FLT30.85460708
75CHEK20.85367591
76IRAK40.84060565
77TAF10.83681188
78LRRK20.83344284
79MAP2K30.79962021
80CSNK2A10.77719489
81RPS6KA50.77640532
82EIF2AK20.74995798
83TAOK20.74246779
84CHEK10.72594669
85STK40.72419412
86MAPKAPK30.71473594
87BLK0.71017117
88PLK20.70000010
89CSNK2A20.67799438
90ERBB30.67097126
91OXSR10.65910408
92WNK40.65851393
93MST40.65756342
94DAPK10.64824924
95MAP2K60.63050234
96MAP3K40.61968654
97MAP2K70.60349383
98PRKCQ0.58968515
99ILK0.58304095
100PBK0.56816070
101JAK30.56720356
102IRAK30.56081391
103TESK10.54695848
104MAP3K110.53471483
105IKBKB0.52640924
106MAP3K120.52631705
107CLK10.52532880
108PAK10.52429338
109BRAF0.51429408
110PHKG10.50669899
111PHKG20.50669899
112CDK20.50639695
113LYN0.50105119
114NLK0.48476571
115MYLK0.47477594
116ADRBK10.46465124
117MAPKAPK50.46357737
118ATM0.45197072
119PRKCG0.44982551
120PRKCE0.44117078
121CSNK1A10.42660175
122LIMK10.42491149
123ADRBK20.42196530
124DAPK30.41067119
125CSF1R0.38767077
126GRK50.38396890
127PRKCI0.38254017
128ABL20.38221273
129SCYL20.37716833
130SYK0.37108491
131YES10.35677892
132BMPR20.35655366
133MUSK0.35634509
134RPS6KA60.35602067
135SIK30.34766996
136TNK20.34383962
137CDK10.33420823
138CDK190.32606569
139RPS6KC10.31959946
140RPS6KL10.31959946
141MATK0.31051170

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79953759
2Ribosome_Homo sapiens_hsa030104.46320938
3Proteasome_Homo sapiens_hsa030504.13114617
4Mismatch repair_Homo sapiens_hsa034304.05411749
5RNA polymerase_Homo sapiens_hsa030203.67754361
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20124118
7* Spliceosome_Homo sapiens_hsa030403.10830385
8Base excision repair_Homo sapiens_hsa034102.97630551
9Homologous recombination_Homo sapiens_hsa034402.95375517
10Nucleotide excision repair_Homo sapiens_hsa034202.86870780
11Pyrimidine metabolism_Homo sapiens_hsa002402.78903218
12RNA transport_Homo sapiens_hsa030132.58736600
13Cell cycle_Homo sapiens_hsa041102.16230912
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13252885
15One carbon pool by folate_Homo sapiens_hsa006702.12032175
16RNA degradation_Homo sapiens_hsa030181.85441996
17Fanconi anemia pathway_Homo sapiens_hsa034601.84908383
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78655542
19Fatty acid elongation_Homo sapiens_hsa000621.75966750
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71626065
21Basal transcription factors_Homo sapiens_hsa030221.69244121
22Non-homologous end-joining_Homo sapiens_hsa034501.65581807
23Protein export_Homo sapiens_hsa030601.61333021
24Purine metabolism_Homo sapiens_hsa002301.53392967
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39339479
26Butanoate metabolism_Homo sapiens_hsa006501.33490483
27Propanoate metabolism_Homo sapiens_hsa006401.31851811
28p53 signaling pathway_Homo sapiens_hsa041151.27673826
29Phototransduction_Homo sapiens_hsa047441.24793227
30Sulfur metabolism_Homo sapiens_hsa009201.19057225
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17599042
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17383645
33Folate biosynthesis_Homo sapiens_hsa007901.12404066
34Peroxisome_Homo sapiens_hsa041461.11483726
35Primary immunodeficiency_Homo sapiens_hsa053401.08724147
36Nitrogen metabolism_Homo sapiens_hsa009101.05748465
37mRNA surveillance pathway_Homo sapiens_hsa030151.05630859
38Cardiac muscle contraction_Homo sapiens_hsa042601.04998160
39Antigen processing and presentation_Homo sapiens_hsa046121.04540058
40Parkinsons disease_Homo sapiens_hsa050121.01335952
41Tryptophan metabolism_Homo sapiens_hsa003800.95000242
42Pentose phosphate pathway_Homo sapiens_hsa000300.94902629
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.94601424
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94188882
45Sulfur relay system_Homo sapiens_hsa041220.91082469
46Collecting duct acid secretion_Homo sapiens_hsa049660.90986284
47Herpes simplex infection_Homo sapiens_hsa051680.89861878
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.89619802
49Huntingtons disease_Homo sapiens_hsa050160.89478103
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86309702
51Oxidative phosphorylation_Homo sapiens_hsa001900.83094311
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.78059253
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76544619
54Pyruvate metabolism_Homo sapiens_hsa006200.73363865
55Systemic lupus erythematosus_Homo sapiens_hsa053220.73212742
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71696007
57Chemical carcinogenesis_Homo sapiens_hsa052040.71573278
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69789870
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.69061664
60Glutathione metabolism_Homo sapiens_hsa004800.66297593
61Linoleic acid metabolism_Homo sapiens_hsa005910.65775085
62Biosynthesis of amino acids_Homo sapiens_hsa012300.65420002
63Legionellosis_Homo sapiens_hsa051340.64687401
64Olfactory transduction_Homo sapiens_hsa047400.62660015
65Viral carcinogenesis_Homo sapiens_hsa052030.62610811
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60982910
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60361308
68Vitamin B6 metabolism_Homo sapiens_hsa007500.59644279
69N-Glycan biosynthesis_Homo sapiens_hsa005100.59304134
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57047950
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56911163
72Measles_Homo sapiens_hsa051620.56877274
73Caffeine metabolism_Homo sapiens_hsa002320.56588865
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55937194
75Selenocompound metabolism_Homo sapiens_hsa004500.55177349
76Fructose and mannose metabolism_Homo sapiens_hsa000510.53886265
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52844842
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52685639
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52350761
80HTLV-I infection_Homo sapiens_hsa051660.52297200
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.50966958
82beta-Alanine metabolism_Homo sapiens_hsa004100.49850467
83Galactose metabolism_Homo sapiens_hsa000520.48792142
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48280200
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46821492
86Hematopoietic cell lineage_Homo sapiens_hsa046400.46382435
87Fatty acid metabolism_Homo sapiens_hsa012120.45002608
88Thyroid cancer_Homo sapiens_hsa052160.44022572
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.43010374
90Carbon metabolism_Homo sapiens_hsa012000.42940535
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42318998
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41900540
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41495020
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.40603786
95Arachidonic acid metabolism_Homo sapiens_hsa005900.40350337
96Metabolic pathways_Homo sapiens_hsa011000.40254909
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39546655
98Other glycan degradation_Homo sapiens_hsa005110.38429115
99Fatty acid degradation_Homo sapiens_hsa000710.37598454
100Apoptosis_Homo sapiens_hsa042100.37425753
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37147376
102Type I diabetes mellitus_Homo sapiens_hsa049400.37025401
103Shigellosis_Homo sapiens_hsa051310.36733561
104Alcoholism_Homo sapiens_hsa050340.36058607
105Ether lipid metabolism_Homo sapiens_hsa005650.35536058
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35404859
107Oocyte meiosis_Homo sapiens_hsa041140.34793560
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34684353
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.34292210
110Retinol metabolism_Homo sapiens_hsa008300.32471910
111Alzheimers disease_Homo sapiens_hsa050100.31804059
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31238682
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31213643
114Regulation of autophagy_Homo sapiens_hsa041400.29725493
115Allograft rejection_Homo sapiens_hsa053300.29215242
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28714973
117Autoimmune thyroid disease_Homo sapiens_hsa053200.27980890
118Rheumatoid arthritis_Homo sapiens_hsa053230.25566609
119Hepatitis B_Homo sapiens_hsa051610.25349231
120Influenza A_Homo sapiens_hsa051640.25169737
121Steroid biosynthesis_Homo sapiens_hsa001000.24693568
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24488676
123Graft-versus-host disease_Homo sapiens_hsa053320.23486068
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23396427
125Small cell lung cancer_Homo sapiens_hsa052220.23191873
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19689041
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.18094142
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16289288
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16216781
130Leishmaniasis_Homo sapiens_hsa051400.16024216
131Asthma_Homo sapiens_hsa053100.14229185
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11784588
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10684170
134Acute myeloid leukemia_Homo sapiens_hsa052210.10149148
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09680007
136HIF-1 signaling pathway_Homo sapiens_hsa040660.09521023
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09367089
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09296002
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09184202
140Vitamin digestion and absorption_Homo sapiens_hsa049770.09040647

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