PPIG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.07839571
2mitotic metaphase plate congression (GO:0007080)5.04904554
3kinetochore organization (GO:0051383)4.89540338
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.69169441
5metaphase plate congression (GO:0051310)4.41700518
6kinetochore assembly (GO:0051382)4.41363040
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.34712124
8negative regulation of DNA-dependent DNA replication (GO:2000104)4.30165197
9nuclear pore complex assembly (GO:0051292)4.05684166
10ATP synthesis coupled proton transport (GO:0015986)4.05502869
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05502869
12translational termination (GO:0006415)4.02052945
13viral transcription (GO:0019083)3.97686330
14regulation of DNA endoreduplication (GO:0032875)3.94638204
15DNA replication checkpoint (GO:0000076)3.92184925
16regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.90796974
17nuclear pore organization (GO:0006999)3.89784298
18CENP-A containing nucleosome assembly (GO:0034080)3.88700271
19regulation of spindle organization (GO:0090224)3.85088453
20meiotic chromosome segregation (GO:0045132)3.80551214
21chromatin remodeling at centromere (GO:0031055)3.75510811
22ribosomal small subunit assembly (GO:0000028)3.73623013
23centriole replication (GO:0007099)3.73543512
24establishment of chromosome localization (GO:0051303)3.72152067
25sister chromatid cohesion (GO:0007062)3.69442259
26attachment of spindle microtubules to kinetochore (GO:0008608)3.67035405
27DNA replication-independent nucleosome assembly (GO:0006336)3.64983201
28DNA replication-independent nucleosome organization (GO:0034724)3.64983201
29ribosome assembly (GO:0042255)3.61024827
30mitotic sister chromatid segregation (GO:0000070)3.59200414
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56620264
32cotranslational protein targeting to membrane (GO:0006613)3.55206388
33ribosomal large subunit biogenesis (GO:0042273)3.54058338
34protein localization to kinetochore (GO:0034501)3.52580547
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51951919
36histone exchange (GO:0043486)3.49399653
37protein targeting to ER (GO:0045047)3.46729980
38positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.46723159
39intra-S DNA damage checkpoint (GO:0031573)3.42122421
40mitotic chromosome condensation (GO:0007076)3.41547241
41chaperone-mediated protein transport (GO:0072321)3.40840030
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.37296715
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36334992
44telomere maintenance via telomerase (GO:0007004)3.35432210
45regulation of mitotic spindle organization (GO:0060236)3.31015927
46microtubule depolymerization (GO:0007019)3.29411107
47respiratory electron transport chain (GO:0022904)3.28291242
48resolution of meiotic recombination intermediates (GO:0000712)3.27648062
49regulation of mitotic spindle checkpoint (GO:1903504)3.27256299
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27256299
51maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22851403
52protein localization to chromosome, centromeric region (GO:0071459)3.21633869
53pore complex assembly (GO:0046931)3.20717881
54protein localization to endoplasmic reticulum (GO:0070972)3.20712245
55electron transport chain (GO:0022900)3.20448538
56spindle checkpoint (GO:0031577)3.19777250
57sister chromatid segregation (GO:0000819)3.18546752
58protein K6-linked ubiquitination (GO:0085020)3.17630414
59positive regulation of chromosome segregation (GO:0051984)3.14576629
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14248731
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14236977
62translational initiation (GO:0006413)3.13505312
63ribosomal small subunit biogenesis (GO:0042274)3.12665232
64maturation of SSU-rRNA (GO:0030490)3.11804746
65regulation of RNA export from nucleus (GO:0046831)3.11519778
66translational elongation (GO:0006414)3.10763093
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06933988
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06933988
69positive regulation of mitotic sister chromatid separation (GO:1901970)3.06933988
70cellular protein complex disassembly (GO:0043624)3.03156455
71positive regulation of histone H3-K4 methylation (GO:0051571)3.03086447
72RNA-dependent DNA replication (GO:0006278)3.00090568
73monoubiquitinated protein deubiquitination (GO:0035520)3.00051292
74establishment of integrated proviral latency (GO:0075713)2.98941183
75mitotic G2/M transition checkpoint (GO:0044818)2.98881908
76synapsis (GO:0007129)2.97373458
77protein complex biogenesis (GO:0070271)2.93133402
78regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91864593
79viral life cycle (GO:0019058)2.91402017
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91323296
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.91323296
82NADH dehydrogenase complex assembly (GO:0010257)2.91323296
83ribosome biogenesis (GO:0042254)2.90814532
84regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.90557818
85regulation of centrosome cycle (GO:0046605)2.89507117
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89283130
87RNA capping (GO:0036260)2.89078869
887-methylguanosine RNA capping (GO:0009452)2.89078869
89ATP-dependent chromatin remodeling (GO:0043044)2.87975708
90replication fork processing (GO:0031297)2.87400293
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.86729501
92chromosome segregation (GO:0007059)2.86298712
937-methylguanosine mRNA capping (GO:0006370)2.85366590
94mitotic spindle checkpoint (GO:0071174)2.84747715
95mitochondrial respiratory chain complex assembly (GO:0033108)2.83618763
96DNA damage response, detection of DNA damage (GO:0042769)2.82384721
97mitotic nuclear envelope disassembly (GO:0007077)2.82102032
98DNA double-strand break processing (GO:0000729)2.81929602
99regulation of chromosome segregation (GO:0051983)2.81686471
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.79956482
101termination of RNA polymerase III transcription (GO:0006386)2.79956482
102regulation of double-strand break repair via homologous recombination (GO:0010569)2.79210978
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78858047
104DNA replication initiation (GO:0006270)2.77961173
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77421635
106regulation of mitotic sister chromatid separation (GO:0010965)2.77224168
107regulation of mitotic sister chromatid segregation (GO:0033047)2.77224168
108regulation of sister chromatid segregation (GO:0033045)2.77224168
109spindle assembly checkpoint (GO:0071173)2.76276522
110chromatin assembly or disassembly (GO:0006333)2.74828068
111regulation of centriole replication (GO:0046599)2.73292994
112histone mRNA metabolic process (GO:0008334)2.72775122
113positive regulation of DNA-templated transcription, elongation (GO:0032786)2.71798875
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.71064046
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71064046
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71064046
117negative regulation of sister chromatid segregation (GO:0033046)2.71064046
118transcription elongation from RNA polymerase II promoter (GO:0006368)2.70300772
119proteasome assembly (GO:0043248)2.70207183
120negative regulation of chromosome segregation (GO:0051985)2.69875797
121inner cell mass cell proliferation (GO:0001833)2.69861641
122mitotic spindle assembly checkpoint (GO:0007094)2.69546831
123regulation of meiosis I (GO:0060631)2.69044483
124protein complex disassembly (GO:0043241)2.68999280
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68335110
126protein localization to chromosome (GO:0034502)2.67085477
127termination of RNA polymerase I transcription (GO:0006363)2.65754805
128ribonucleoprotein complex biogenesis (GO:0022613)2.65633714
129negative regulation of DNA recombination (GO:0045910)2.65275419
130protein neddylation (GO:0045116)2.65199476
131maturation of 5.8S rRNA (GO:0000460)2.65115423
132RNA splicing, via transesterification reactions (GO:0000375)2.64464504
133spliceosomal complex assembly (GO:0000245)2.64110617
134rRNA processing (GO:0006364)2.63945961
135macromolecular complex disassembly (GO:0032984)2.63512663
136regulation of spindle checkpoint (GO:0090231)2.62946600
137inner mitochondrial membrane organization (GO:0007007)2.62936739
138translation (GO:0006412)2.62644773
139telomere maintenance via semi-conservative replication (GO:0032201)2.62335174
140regulation of sister chromatid cohesion (GO:0007063)2.61749420
141DNA ligation (GO:0006266)2.61616569
142neuron fate determination (GO:0048664)2.61413483
143DNA-templated transcription, elongation (GO:0006354)2.61369178
144nuclear-transcribed mRNA catabolic process (GO:0000956)2.60616038
145nuclear envelope disassembly (GO:0051081)2.59268634
146membrane disassembly (GO:0030397)2.59268634
147rRNA metabolic process (GO:0016072)2.58938335
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57980400
149mRNA splicing, via spliceosome (GO:0000398)2.57980400
150histone H2B ubiquitination (GO:0033523)2.57439090
151centriole assembly (GO:0098534)2.57194048
152regulation of helicase activity (GO:0051095)2.56686206
153nucleotide-excision repair, DNA gap filling (GO:0006297)2.51887706
154recombinational repair (GO:0000725)2.51432787
155DNA topological change (GO:0006265)2.50951120
156postreplication repair (GO:0006301)2.49522422
157double-strand break repair via homologous recombination (GO:0000724)2.49086616
158mRNA catabolic process (GO:0006402)2.47690378
159DNA strand elongation involved in DNA replication (GO:0006271)2.47627563
160regulation of DNA methylation (GO:0044030)2.47617142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44622418
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.44341835
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00651587
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27476534
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.16772482
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10471370
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05938072
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.99671859
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.97283424
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.72251757
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69625547
12EZH2_22144423_ChIP-Seq_EOC_Human2.63496668
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.41687269
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37203644
15AR_21909140_ChIP-Seq_LNCAP_Human2.33207131
16VDR_22108803_ChIP-Seq_LS180_Human2.31720974
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30954566
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.26635573
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15374877
20ELK1_19687146_ChIP-ChIP_HELA_Human2.14578331
21FUS_26573619_Chip-Seq_HEK293_Human2.14309153
22* E2F1_21310950_ChIP-Seq_MCF-7_Human2.05610159
23EWS_26573619_Chip-Seq_HEK293_Human2.02557986
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01797274
25VDR_23849224_ChIP-Seq_CD4+_Human1.97133105
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97011585
27ZNF274_21170338_ChIP-Seq_K562_Hela1.94029834
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.93132052
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86169190
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74436525
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74121605
32TTF2_22483619_ChIP-Seq_HELA_Human1.72697909
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.72143316
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70080187
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69599274
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67387260
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.66399921
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66381195
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65185823
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60077641
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58464458
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55753188
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54453306
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54218782
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53564486
46FOXP3_21729870_ChIP-Seq_TREG_Human1.53003804
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52314817
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42699865
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.41575689
50* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41168213
51MYC_18940864_ChIP-ChIP_HL60_Human1.39819838
52GBX2_23144817_ChIP-Seq_PC3_Human1.38838555
53IGF1R_20145208_ChIP-Seq_DFB_Human1.37372777
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34101487
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33508023
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31377421
57* XRN2_22483619_ChIP-Seq_HELA_Human1.30302277
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25927799
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.25685678
60TAF15_26573619_Chip-Seq_HEK293_Human1.25660694
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.24929415
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.23798319
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22647545
64DCP1A_22483619_ChIP-Seq_HELA_Human1.22253124
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21584331
66KDM5A_27292631_Chip-Seq_BREAST_Human1.21252259
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20047555
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19054099
69RNF2_27304074_Chip-Seq_NSC_Mouse1.16408784
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.15131427
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15086179
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14724745
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14697386
74* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12540511
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12002735
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09742185
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09742185
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07991256
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07963484
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07626760
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07213337
82* GABP_19822575_ChIP-Seq_HepG2_Human1.06712762
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06431341
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06368730
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05988852
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05809922
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04046879
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03426046
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03334022
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.01160915
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00955300
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00650460
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99587749
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98747308
95CBP_20019798_ChIP-Seq_JUKART_Human0.97887850
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97887850
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97597240
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96923348
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96723328
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96019230
101YY1_21170310_ChIP-Seq_MESCs_Mouse0.94904419
102SRF_21415370_ChIP-Seq_HL-1_Mouse0.94064151
103TP53_22573176_ChIP-Seq_HFKS_Human0.93933810
104NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93783108
105SMAD4_21799915_ChIP-Seq_A2780_Human0.92426726
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91258254
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.90961071
108BP1_19119308_ChIP-ChIP_Hs578T_Human0.90435631
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.89969551
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.89350765
111BCAT_22108803_ChIP-Seq_LS180_Human0.88985980
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88917906
113IRF1_19129219_ChIP-ChIP_H3396_Human0.88020457
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87589807
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87589807
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87589807
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87106611
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86969606
119AR_25329375_ChIP-Seq_VCAP_Human0.86936960
120CIITA_25753668_ChIP-Seq_RAJI_Human0.86554735
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.84786201
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.84240870
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84149915
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83014458
125ER_23166858_ChIP-Seq_MCF-7_Human0.82104853
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82034125
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80487249
128P300_19829295_ChIP-Seq_ESCs_Human0.77610227
129* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77521971
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77281229
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76982139
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.75712423
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74458670
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.74293194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.15001368
2MP0008057_abnormal_DNA_replication3.79159829
3MP0010094_abnormal_chromosome_stability3.59828974
4MP0008877_abnormal_DNA_methylation3.36908401
5MP0003111_abnormal_nucleus_morphology3.29807669
6MP0004957_abnormal_blastocyst_morpholog3.09467186
7MP0003077_abnormal_cell_cycle2.87443638
8MP0008058_abnormal_DNA_repair2.85516195
9MP0003787_abnormal_imprinting2.80190296
10MP0003123_paternal_imprinting2.79270643
11MP0006292_abnormal_olfactory_placode2.60071950
12MP0003121_genomic_imprinting2.46760144
13MP0001188_hyperpigmentation2.23596104
14MP0008007_abnormal_cellular_replicative2.08722348
15MP0000566_synostosis2.06169118
16MP0008932_abnormal_embryonic_tissue2.05389819
17MP0003718_maternal_effect2.01697851
18MP0002396_abnormal_hematopoietic_system1.99100332
19MP0002163_abnormal_gland_morphology1.98334287
20MP0000350_abnormal_cell_proliferation1.72117778
21MP0001730_embryonic_growth_arrest1.64321918
22MP0006072_abnormal_retinal_apoptosis1.64085093
23MP0003890_abnormal_embryonic-extraembry1.60636680
24MP0001346_abnormal_lacrimal_gland1.60404476
25MP0003941_abnormal_skin_development1.57223446
26MP0003315_abnormal_perineum_morphology1.52137186
27MP0003937_abnormal_limbs/digits/tail_de1.51422668
28MP0003136_yellow_coat_color1.48364666
29MP0002638_abnormal_pupillary_reflex1.44836074
30MP0003938_abnormal_ear_development1.43293386
31MP0002277_abnormal_respiratory_mucosa1.41811166
32MP0001672_abnormal_embryogenesis/_devel1.41337875
33MP0005380_embryogenesis_phenotype1.41337875
34MP0002210_abnormal_sex_determination1.36038029
35MP0001984_abnormal_olfaction1.33490110
36MP0004142_abnormal_muscle_tone1.33419335
37MP0005551_abnormal_eye_electrophysiolog1.31595808
38MP0002102_abnormal_ear_morphology1.30648157
39MP0005394_taste/olfaction_phenotype1.30286641
40MP0005499_abnormal_olfactory_system1.30286641
41MP0004133_heterotaxia1.30124511
42MP0001697_abnormal_embryo_size1.29456589
43MP0003755_abnormal_palate_morphology1.28746699
44MP0002085_abnormal_embryonic_tissue1.25931053
45MP0002084_abnormal_developmental_patter1.25452857
46MP0003786_premature_aging1.25355407
47MP0003984_embryonic_growth_retardation1.20808680
48MP0002272_abnormal_nervous_system1.16923614
49MP0009250_abnormal_appendicular_skeleto1.16889155
50MP0003122_maternal_imprinting1.16636376
51MP0002088_abnormal_embryonic_growth/wei1.16584323
52MP0000569_abnormal_digit_pigmentation1.15606185
53MP0002938_white_spotting1.12454438
54MP0009046_muscle_twitch1.12071190
55MP0005646_abnormal_pituitary_gland1.11835913
56MP0004885_abnormal_endolymph1.11223926
57MP0005257_abnormal_intraocular_pressure1.07638536
58MP0009379_abnormal_foot_pigmentation1.06440730
59MP0003567_abnormal_fetal_cardiomyocyte1.06093716
60MP0000049_abnormal_middle_ear1.04843771
61MP0001145_abnormal_male_reproductive1.04214643
62MP0000653_abnormal_sex_gland1.03588301
63MP0000432_abnormal_head_morphology1.03276420
64MP0005076_abnormal_cell_differentiation1.02882340
65MP0004147_increased_porphyrin_level1.00681240
66MP0002697_abnormal_eye_size1.00097911
67MP0002653_abnormal_ependyma_morphology0.99404148
68MP0009745_abnormal_behavioral_response0.99056965
69MP0005379_endocrine/exocrine_gland_phen0.97939777
70MP0005253_abnormal_eye_physiology0.97647705
71MP0002177_abnormal_outer_ear0.97377278
72MP0003385_abnormal_body_wall0.97238995
73MP0003880_abnormal_central_pattern0.96964177
74MP0006276_abnormal_autonomic_nervous0.94721001
75MP0000428_abnormal_craniofacial_morphol0.93629915
76MP0002837_dystrophic_cardiac_calcinosis0.93184250
77MP0001929_abnormal_gametogenesis0.92984004
78MP0001119_abnormal_female_reproductive0.92784449
79MP0002557_abnormal_social/conspecific_i0.92666134
80MP0000516_abnormal_urinary_system0.92307884
81MP0005367_renal/urinary_system_phenotyp0.92307884
82MP0001486_abnormal_startle_reflex0.91899630
83MP0002234_abnormal_pharynx_morphology0.91173218
84MP0001286_abnormal_eye_development0.90564347
85MP0005195_abnormal_posterior_eye0.90467150
86MP0009697_abnormal_copulation0.90184073
87MP0003186_abnormal_redox_activity0.90164195
88MP0000015_abnormal_ear_pigmentation0.88747360
89MP0010307_abnormal_tumor_latency0.88677263
90MP0005084_abnormal_gallbladder_morpholo0.88495454
91MP0002751_abnormal_autonomic_nervous0.88226482
92MP0005391_vision/eye_phenotype0.87845019
93MP0009053_abnormal_anal_canal0.87737847
94MP0002736_abnormal_nociception_after0.87434127
95MP0001529_abnormal_vocalization0.87262099
96MP0005187_abnormal_penis_morphology0.87061968
97MP0002080_prenatal_lethality0.86878415
98MP0005409_darkened_coat_color0.86732343
99MP0004197_abnormal_fetal_growth/weight/0.86047355
100MP0002086_abnormal_extraembryonic_tissu0.85785851
101MP0001485_abnormal_pinna_reflex0.85460700
102MP0000313_abnormal_cell_death0.84957916
103MP0005389_reproductive_system_phenotype0.84712155
104MP0000955_abnormal_spinal_cord0.83764079
105MP0001293_anophthalmia0.83289677
106MP0002752_abnormal_somatic_nervous0.82786569
107MP0009703_decreased_birth_body0.82491549
108MP0003698_abnormal_male_reproductive0.81824909
109MP0008789_abnormal_olfactory_epithelium0.81038713
110MP0002160_abnormal_reproductive_system0.80618987
111MP0001919_abnormal_reproductive_system0.80475270
112MP0004742_abnormal_vestibular_system0.80361606
113MP0000372_irregular_coat_pigmentation0.79990383
114MP0003935_abnormal_craniofacial_develop0.79667628
115MP0003635_abnormal_synaptic_transmissio0.79662235
116MP0006035_abnormal_mitochondrial_morpho0.78142104
117MP0000631_abnormal_neuroendocrine_gland0.77778172
118MP0000427_abnormal_hair_cycle0.77131726
119MP0003195_calcinosis0.77035905
120MP0001968_abnormal_touch/_nociception0.77023295
121MP0002116_abnormal_craniofacial_bone0.76392196
122MP0002067_abnormal_sensory_capabilities0.76251937
123MP0002152_abnormal_brain_morphology0.76219381
124MP0000647_abnormal_sebaceous_gland0.76116558
125MP0010030_abnormal_orbit_morphology0.74748293
126MP0004808_abnormal_hematopoietic_stem0.74583924
127MP0002009_preneoplasia0.73777507
128MP0003936_abnormal_reproductive_system0.73229502
129MP0001299_abnormal_eye_distance/0.72206773
130MP0003861_abnormal_nervous_system0.71535140
131MP0000778_abnormal_nervous_system0.70598464
132MP0000627_abnormal_mammary_gland0.69536655
133MP0002095_abnormal_skin_pigmentation0.68466835
134MP0002233_abnormal_nose_morphology0.67784494
135MP0002877_abnormal_melanocyte_morpholog0.64672856
136MP0001986_abnormal_taste_sensitivity0.64411693
137MP0002114_abnormal_axial_skeleton0.64275845
138MP0009333_abnormal_splenocyte_physiolog0.63588888
139MP0008995_early_reproductive_senescence0.63085505
140MP0003119_abnormal_digestive_system0.62498134
141MP0002109_abnormal_limb_morphology0.62403814
142MP0005248_abnormal_Harderian_gland0.61049186
143MP0002019_abnormal_tumor_incidence0.60843464

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.26758525
2Birth length less than 3rd percentile (HP:0003561)4.22710472
3Volvulus (HP:0002580)4.14649988
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89260161
5Abnormality of the labia minora (HP:0012880)3.81897464
6Acute necrotizing encephalopathy (HP:0006965)3.37687614
7Breast hypoplasia (HP:0003187)3.17942614
8Facial hemangioma (HP:0000329)3.17366174
9Patellar aplasia (HP:0006443)3.14938970
10Impulsivity (HP:0100710)3.11166162
11Acute encephalopathy (HP:0006846)2.93698826
12Aplasia/Hypoplasia of the patella (HP:0006498)2.93547642
13Macrocytic anemia (HP:0001972)2.91247275
14Ectopic kidney (HP:0000086)2.86913125
15Increased hepatocellular lipid droplets (HP:0006565)2.83300167
16Progressive macrocephaly (HP:0004481)2.83283979
17Abnormality of the preputium (HP:0100587)2.81014509
18Abnormal mitochondria in muscle tissue (HP:0008316)2.79629193
19Meckel diverticulum (HP:0002245)2.78661335
20Abnormality of chromosome stability (HP:0003220)2.75956740
21Abnormal hair whorl (HP:0010721)2.74837538
22Lipid accumulation in hepatocytes (HP:0006561)2.65719273
23Abnormality of cells of the erythroid lineage (HP:0012130)2.64266974
24Absent radius (HP:0003974)2.63567843
25Nephronophthisis (HP:0000090)2.59887396
26Mitochondrial inheritance (HP:0001427)2.58122324
27Abnormality of the ileum (HP:0001549)2.54644286
28Oligodactyly (HP:0012165)2.51621572
29Oligodactyly (hands) (HP:0001180)2.51318643
30Capillary hemangiomas (HP:0005306)2.50898405
31True hermaphroditism (HP:0010459)2.50895341
32Absent forearm bone (HP:0003953)2.49078125
33Aplasia involving forearm bones (HP:0009822)2.49078125
34Increased CSF lactate (HP:0002490)2.47357988
35Shawl scrotum (HP:0000049)2.46648135
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.44563087
37Medial flaring of the eyebrow (HP:0010747)2.40289187
38Prostate neoplasm (HP:0100787)2.37541590
39Abnormal number of erythroid precursors (HP:0012131)2.25970534
40Methylmalonic acidemia (HP:0002912)2.25588506
41Supernumerary spleens (HP:0009799)2.23349662
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.19476074
43Horseshoe kidney (HP:0000085)2.17940005
44Short middle phalanx of the 5th finger (HP:0004220)2.14839490
45Abnormality of the nasal septum (HP:0000419)2.14254549
46Abnormality of the renal medulla (HP:0100957)2.13966894
47Abnormality of the parietal bone (HP:0002696)2.11932079
48Lip pit (HP:0100267)2.11366007
49Acute myeloid leukemia (HP:0004808)2.11226209
50Congenital, generalized hypertrichosis (HP:0004540)2.10321125
51Anophthalmia (HP:0000528)2.10007996
52Sclerocornea (HP:0000647)2.09195192
53Cerebral edema (HP:0002181)2.09040890
54Myelodysplasia (HP:0002863)2.08555834
55Gait imbalance (HP:0002141)2.07748943
56Optic nerve hypoplasia (HP:0000609)2.07180570
57Abnormality of the phalanges of the hallux (HP:0010057)2.06730705
58Nephroblastoma (Wilms tumor) (HP:0002667)2.05949629
59Pallor (HP:0000980)2.04224939
60Triphalangeal thumb (HP:0001199)2.03667072
61Abnormal number of incisors (HP:0011064)2.02442613
62Maternal diabetes (HP:0009800)1.99108555
63Congenital primary aphakia (HP:0007707)1.98889073
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96698974
65Atresia of the external auditory canal (HP:0000413)1.95848458
66Intestinal atresia (HP:0011100)1.95446387
67Pancreatic fibrosis (HP:0100732)1.95288942
68Hyperglycinemia (HP:0002154)1.95092934
69Genital tract atresia (HP:0001827)1.94873174
70Pancreatic cysts (HP:0001737)1.94636497
71Clubbing of toes (HP:0100760)1.94285983
72Embryonal renal neoplasm (HP:0011794)1.94241058
73Small intestinal stenosis (HP:0012848)1.94151508
74Duodenal stenosis (HP:0100867)1.94151508
75Renal Fanconi syndrome (HP:0001994)1.92644986
76Microtia (HP:0008551)1.92355179
77Long eyelashes (HP:0000527)1.91817541
78Hepatocellular necrosis (HP:0001404)1.91123756
79Abnormality of incisor morphology (HP:0011063)1.89990016
80Cleft eyelid (HP:0000625)1.89544630
81Gastrointestinal atresia (HP:0002589)1.89087194
82Abnormality of the fingertips (HP:0001211)1.88566734
83Supernumerary bones of the axial skeleton (HP:0009144)1.88413600
84Aplasia/Hypoplasia of the earlobes (HP:0009906)1.88402170
85Papillary thyroid carcinoma (HP:0002895)1.88377287
86Adrenal hypoplasia (HP:0000835)1.87434950
87Supernumerary ribs (HP:0005815)1.85772375
88Breast aplasia (HP:0100783)1.85453310
89Vaginal atresia (HP:0000148)1.85113404
90Gonadotropin excess (HP:0000837)1.84521332
91Poor coordination (HP:0002370)1.83397579
92Abnormal trabecular bone morphology (HP:0100671)1.83334100
93Abnormality of the columella (HP:0009929)1.83104216
94Leukodystrophy (HP:0002415)1.82479626
95Median cleft lip (HP:0000161)1.82035913
96Reticulocytopenia (HP:0001896)1.81717665
97Increased number of teeth (HP:0011069)1.81651978
98Bifid tongue (HP:0010297)1.81291770
99Abnormality of the incisor (HP:0000676)1.81082965
100Aplasia/Hypoplasia of the breasts (HP:0010311)1.80505058
101Anencephaly (HP:0002323)1.79859133
102Absent thumb (HP:0009777)1.79267026
103Sparse lateral eyebrow (HP:0005338)1.78646315
104Male pseudohermaphroditism (HP:0000037)1.78636815
105Rough bone trabeculation (HP:0100670)1.78459132
106Abnormality of the septum pellucidum (HP:0007375)1.78405098
107Colon cancer (HP:0003003)1.77922013
108Proximal placement of thumb (HP:0009623)1.77912483
109Premature graying of hair (HP:0002216)1.77881045
110Abnormality of the carotid arteries (HP:0005344)1.77023284
111Esophageal atresia (HP:0002032)1.76963558
112Hepatic necrosis (HP:0002605)1.76406921
113Abnormality of renal resorption (HP:0011038)1.76004809
114Hypoplastic iliac wings (HP:0002866)1.72617741
115Septo-optic dysplasia (HP:0100842)1.72611176
116Respiratory difficulties (HP:0002880)1.72059246
117Nephrogenic diabetes insipidus (HP:0009806)1.71531221
118Short thumb (HP:0009778)1.71481530
119Tubulointerstitial nephritis (HP:0001970)1.69307414
120Limb dystonia (HP:0002451)1.68801075
121Bone marrow hypocellularity (HP:0005528)1.68668945
122Sloping forehead (HP:0000340)1.67146573
123Abnormality of the renal cortex (HP:0011035)1.66832661
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.66273020
125Prominent nose (HP:0000448)1.65804396
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65114554
127Blepharitis (HP:0000498)1.64709855
128Deviation of the thumb (HP:0009603)1.64451857
129Preaxial hand polydactyly (HP:0001177)1.63603309
130Carpal bone hypoplasia (HP:0001498)1.63557101
131Optic disc pallor (HP:0000543)1.63158965
132Aplasia cutis congenita (HP:0001057)1.63155204
133Abnormal lung lobation (HP:0002101)1.62821090
134Tracheoesophageal fistula (HP:0002575)1.62777494
135Medulloblastoma (HP:0002885)1.62441587
136Abnormality of the duodenum (HP:0002246)1.61166584
137Abnormal biliary tract physiology (HP:0012439)1.60856829
138Bile duct proliferation (HP:0001408)1.60856829
139Microglossia (HP:0000171)1.60433662
140Small hand (HP:0200055)1.60084821
141Rib fusion (HP:0000902)1.59790300
142Cystic liver disease (HP:0006706)1.58625924
143Megaloblastic anemia (HP:0001889)1.58246831
144Holoprosencephaly (HP:0001360)1.57742148
145Arteriovenous malformation (HP:0100026)1.57205999
146Abnormality of abdominal situs (HP:0011620)1.56697381
147Flat capital femoral epiphysis (HP:0003370)1.56265775
148Absent septum pellucidum (HP:0001331)1.54856788
149Choanal atresia (HP:0000453)1.52379245
150Aplastic anemia (HP:0001915)1.51755829
151Absent eyebrow (HP:0002223)1.50076821
152Increased nuchal translucency (HP:0010880)1.48726844
153Sparse scalp hair (HP:0002209)1.48002796
154Molar tooth sign on MRI (HP:0002419)1.47205546
155Abnormality of midbrain morphology (HP:0002418)1.47205546
156Abnormality of DNA repair (HP:0003254)1.46539542
157Agnosia (HP:0010524)1.44571262
158Aganglionic megacolon (HP:0002251)1.44375700
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.44346682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.43715174
2MKNK23.66415028
3SRPK13.57341679
4CDK123.14979051
5WEE13.13277450
6MKNK13.06223021
7PLK42.88102594
8PNCK2.87656569
9WNK32.70683337
10BRSK22.49734196
11BUB12.43903235
12CDK82.42494687
13PLK32.28644610
14EIF2AK11.95246409
15NEK11.88559182
16NEK21.84182045
17VRK21.78681795
18TAF11.76106984
19TTK1.74837590
20PLK11.73839252
21LATS11.72043658
22CHEK21.61734109
23CASK1.61414285
24AKT31.58694721
25TSSK61.57354396
26STK38L1.51039617
27CDK71.48175617
28PLK21.45078030
29NUAK11.42750157
30LATS21.40154614
31PBK1.37834116
32VRK11.34077160
33BRSK11.31171617
34STK31.30975725
35AURKB1.27266188
36CHEK11.26312093
37MAP3K41.17576080
38BRD41.16781619
39ATR1.14985253
40WNK41.14630407
41CDK31.13422086
42ATM1.10859233
43PRKCG1.07440236
44TRIM281.06645854
45RPS6KA41.05587316
46BMPR1B1.04013227
47EIF2AK31.03516111
48INSRR1.01949835
49EIF2AK21.01398515
50MARK10.98620745
51STK390.93488128
52MAP4K20.91499349
53* CDK20.88577623
54CCNB10.88011958
55ACVR1B0.86378901
56DYRK30.85017812
57PAK30.83714005
58NTRK20.82431002
59ALK0.80969973
60CDK10.80948066
61FRK0.77968648
62PASK0.77337097
63MELK0.76494989
64* CSNK1E0.75985402
65AURKA0.74168068
66CDK190.73500634
67BRAF0.72221239
68MAP2K70.71630454
69BMPR20.70847668
70NME20.70048730
71GRK10.68233373
72CDK60.67646174
73MAP3K90.67002966
74OXSR10.66828173
75NEK60.66351331
76STK240.66166275
77UHMK10.65631887
78BCR0.64715727
79* CSNK2A20.64506091
80CSNK2A10.62951129
81RIPK40.62170832
82YES10.61624775
83CDK40.59419300
84MINK10.59417764
85CAMK1G0.57949215
86NLK0.57762560
87PINK10.57677662
88TGFBR10.56575014
89PDK20.56030400
90EPHA40.55115658
91MAPK140.54953920
92STK160.50095988
93STK40.49954393
94SGK10.49937498
95DYRK1A0.49401779
96NME10.48318563
97PRKG10.47297965
98ERBB40.47215293
99ZAK0.47014557
100MAPK100.46460004
101MARK30.46209603
102CSNK1G10.46071724
103FGFR10.46012699
104MAPK130.45962944
105MST40.45959630
106CSNK1A1L0.45489824
107PRKDC0.44448142
108STK100.44133450
109TNIK0.42929916
110ADRBK20.41386647
111* GSK3B0.41197899
112TYRO30.41154193
113TAOK30.40431708
114KSR10.40016014
115FGFR20.39986677
116RPS6KA50.39805572
117* PRKACB0.38482626
118CSNK1D0.38405913
119CSNK1G30.38133236
120TEC0.37572888
121CSNK1G20.37426153
122CDK90.34853481
123PIM10.34280175
124SIK30.33339788
125CSNK1A10.32573419
126RAF10.32031228
127IRAK40.31930867
128PIK3CA0.31915686
129CHUK0.31624032
130NTRK30.31202475
131DYRK20.31171185
132GRK70.29861193
133DMPK0.29523701
134PIM20.29401434

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.45313110
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44104125
3RNA polymerase_Homo sapiens_hsa030203.31142269
4Basal transcription factors_Homo sapiens_hsa030223.23731910
5Homologous recombination_Homo sapiens_hsa034402.92392016
6Parkinsons disease_Homo sapiens_hsa050122.91015080
7Spliceosome_Homo sapiens_hsa030402.90008160
8RNA transport_Homo sapiens_hsa030132.77930044
9Cell cycle_Homo sapiens_hsa041102.68237758
10Mismatch repair_Homo sapiens_hsa034302.49085494
11DNA replication_Homo sapiens_hsa030302.42553730
12Fanconi anemia pathway_Homo sapiens_hsa034602.32462643
13Non-homologous end-joining_Homo sapiens_hsa034502.32045077
14RNA degradation_Homo sapiens_hsa030182.17771050
15mRNA surveillance pathway_Homo sapiens_hsa030152.07132988
16Nucleotide excision repair_Homo sapiens_hsa034202.02380871
17Alzheimers disease_Homo sapiens_hsa050101.88624438
18Proteasome_Homo sapiens_hsa030501.84071880
19Ribosome_Homo sapiens_hsa030101.82681874
20Cardiac muscle contraction_Homo sapiens_hsa042601.79078919
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66586208
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58426516
23Pyrimidine metabolism_Homo sapiens_hsa002401.53198922
24Base excision repair_Homo sapiens_hsa034101.52039809
25Oocyte meiosis_Homo sapiens_hsa041141.42410266
26p53 signaling pathway_Homo sapiens_hsa041151.40205755
27Propanoate metabolism_Homo sapiens_hsa006401.38114753
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.32230089
29Folate biosynthesis_Homo sapiens_hsa007901.30804958
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30722191
31Selenocompound metabolism_Homo sapiens_hsa004501.29484409
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20995499
33Epstein-Barr virus infection_Homo sapiens_hsa051691.13547919
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11610675
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11261379
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09312154
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.07611195
38Protein export_Homo sapiens_hsa030601.05760247
39Caffeine metabolism_Homo sapiens_hsa002321.04323259
40Purine metabolism_Homo sapiens_hsa002301.04217627
41Herpes simplex infection_Homo sapiens_hsa051681.01554149
42MicroRNAs in cancer_Homo sapiens_hsa052060.95929717
43Butanoate metabolism_Homo sapiens_hsa006500.95857223
44Prostate cancer_Homo sapiens_hsa052150.92973975
45TGF-beta signaling pathway_Homo sapiens_hsa043500.89196574
46Steroid biosynthesis_Homo sapiens_hsa001000.89063794
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88212053
48Pyruvate metabolism_Homo sapiens_hsa006200.82689072
49Phototransduction_Homo sapiens_hsa047440.78557788
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77598554
51Nicotine addiction_Homo sapiens_hsa050330.76291244
52Thyroid cancer_Homo sapiens_hsa052160.75977268
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75380375
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73980524
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73581515
56Melanoma_Homo sapiens_hsa052180.72847818
57Wnt signaling pathway_Homo sapiens_hsa043100.72627413
58Renal cell carcinoma_Homo sapiens_hsa052110.70322346
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69876828
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69249117
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67654726
62Olfactory transduction_Homo sapiens_hsa047400.65956349
63HTLV-I infection_Homo sapiens_hsa051660.65304169
64Colorectal cancer_Homo sapiens_hsa052100.64975293
65Vitamin B6 metabolism_Homo sapiens_hsa007500.64218917
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63320393
67Viral carcinogenesis_Homo sapiens_hsa052030.63282800
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62839634
69Long-term potentiation_Homo sapiens_hsa047200.61640884
70Linoleic acid metabolism_Homo sapiens_hsa005910.60408200
71Hepatitis B_Homo sapiens_hsa051610.60053443
72Huntingtons disease_Homo sapiens_hsa050160.58776119
73Autoimmune thyroid disease_Homo sapiens_hsa053200.58303552
74Graft-versus-host disease_Homo sapiens_hsa053320.57041541
75Insulin secretion_Homo sapiens_hsa049110.56715598
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55838201
77Antigen processing and presentation_Homo sapiens_hsa046120.55745367
78Amphetamine addiction_Homo sapiens_hsa050310.54932552
79Hippo signaling pathway_Homo sapiens_hsa043900.54670464
80GABAergic synapse_Homo sapiens_hsa047270.53961177
81Pathways in cancer_Homo sapiens_hsa052000.53094625
82Metabolic pathways_Homo sapiens_hsa011000.52447957
83Circadian rhythm_Homo sapiens_hsa047100.52143191
84Type I diabetes mellitus_Homo sapiens_hsa049400.51334625
85Regulation of autophagy_Homo sapiens_hsa041400.50734995
86Long-term depression_Homo sapiens_hsa047300.50623653
87Adherens junction_Homo sapiens_hsa045200.50572219
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.50340120
89FoxO signaling pathway_Homo sapiens_hsa040680.49952467
90Retinol metabolism_Homo sapiens_hsa008300.49894776
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49240892
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49091086
93One carbon pool by folate_Homo sapiens_hsa006700.49088840
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48264438
95Nitrogen metabolism_Homo sapiens_hsa009100.48220075
96Serotonergic synapse_Homo sapiens_hsa047260.48134572
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47964942
98Rheumatoid arthritis_Homo sapiens_hsa053230.47960177
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47608525
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47240778
101Basal cell carcinoma_Homo sapiens_hsa052170.47014231
102Pancreatic cancer_Homo sapiens_hsa052120.46596515
103Morphine addiction_Homo sapiens_hsa050320.46594016
104Allograft rejection_Homo sapiens_hsa053300.44407992
105Small cell lung cancer_Homo sapiens_hsa052220.43867946
106Vitamin digestion and absorption_Homo sapiens_hsa049770.41601107
107Measles_Homo sapiens_hsa051620.40818278
108Hedgehog signaling pathway_Homo sapiens_hsa043400.40720039
109Hematopoietic cell lineage_Homo sapiens_hsa046400.40719651
110Peroxisome_Homo sapiens_hsa041460.40422477
111Influenza A_Homo sapiens_hsa051640.39413076
112Asthma_Homo sapiens_hsa053100.39358229
113Tryptophan metabolism_Homo sapiens_hsa003800.37749186
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36752898
115Circadian entrainment_Homo sapiens_hsa047130.36461590
116Ether lipid metabolism_Homo sapiens_hsa005650.36317715
117Glutamatergic synapse_Homo sapiens_hsa047240.36315672
118Ras signaling pathway_Homo sapiens_hsa040140.35793851
119Sphingolipid metabolism_Homo sapiens_hsa006000.35519114
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.34603963
121Glioma_Homo sapiens_hsa052140.34338491
122Chemical carcinogenesis_Homo sapiens_hsa052040.33822303
123ErbB signaling pathway_Homo sapiens_hsa040120.33781068
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33780813
125Melanogenesis_Homo sapiens_hsa049160.33666050
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.33104487
127Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32566852
128MAPK signaling pathway_Homo sapiens_hsa040100.32408918
129Dorso-ventral axis formation_Homo sapiens_hsa043200.32363766
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32000244
131Endometrial cancer_Homo sapiens_hsa052130.31722877
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31630224
133Dopaminergic synapse_Homo sapiens_hsa047280.31542735
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30829557
135T cell receptor signaling pathway_Homo sapiens_hsa046600.29970334
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.29443145
137mTOR signaling pathway_Homo sapiens_hsa041500.29256640
138HIF-1 signaling pathway_Homo sapiens_hsa040660.29176762
139Choline metabolism in cancer_Homo sapiens_hsa052310.29013776
140Collecting duct acid secretion_Homo sapiens_hsa049660.28996627
141Chronic myeloid leukemia_Homo sapiens_hsa052200.28382139
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28000089
143Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27912945
144Glutathione metabolism_Homo sapiens_hsa004800.27728825
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27437441
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27210841
147Taste transduction_Homo sapiens_hsa047420.26805462
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.25676886
149Arachidonic acid metabolism_Homo sapiens_hsa005900.25495788
150Fatty acid degradation_Homo sapiens_hsa000710.24835324
151Fatty acid metabolism_Homo sapiens_hsa012120.24389558
152beta-Alanine metabolism_Homo sapiens_hsa004100.21645923
153alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21393812
154Cocaine addiction_Homo sapiens_hsa050300.20716491
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20358790
156Fatty acid elongation_Homo sapiens_hsa000620.19379794

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