ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic sister chromatid cohesion (GO:0007064)	8.22958331
2	replication fork processing (GO:0031297)	7.56107231
3	somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.35517062
4	somatic hypermutation of immunoglobulin genes (GO:0016446)	6.35517062
5	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	6.09767160
6	DNA strand renaturation (GO:0000733)	5.89654718
7	kinetochore organization (GO:0051383)	5.88224149
8	negative regulation of DNA recombination (GO:0045910)	5.86763187
9	kinetochore assembly (GO:0051382)	5.68334920
10	regulation of double-strand break repair via homologous recombination (GO:0010569)	5.45693110
11	negative regulation of DNA-dependent DNA replication (GO:2000104)	4.95715349
12	L-serine metabolic process (GO:0006563)	4.51291926
13	protein prenylation (GO:0018342)	4.25849070
14	prenylation (GO:0097354)	4.25849070
15	biotin metabolic process (GO:0006768)	4.18959015
16	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	4.15393982
17	isotype switching (GO:0045190)	4.15393982
18	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	4.15393982
19	ER overload response (GO:0006983)	4.14128061
20	DNA double-strand break processing (GO:0000729)	4.05982881
21	mitotic chromosome condensation (GO:0007076)	3.89587414
22	sister chromatid cohesion (GO:0007062)	3.89508088
23	signal peptide processing (GO:0006465)	3.85659676
24	mismatch repair (GO:0006298)	3.79761697
25	DNA replication-dependent nucleosome assembly (GO:0006335)	3.78814494
26	DNA replication-dependent nucleosome organization (GO:0034723)	3.78814494
27	regulation of centriole replication (GO:0046599)	3.78671643
28	ubiquinone biosynthetic process (GO:0006744)	3.76173136
29	regulation of helicase activity (GO:0051095)	3.75211460
30	regulation of centrosome cycle (GO:0046605)	3.73848177
31	reciprocal DNA recombination (GO:0035825)	3.69225268
32	reciprocal meiotic recombination (GO:0007131)	3.69225268
33	regulation of centrosome duplication (GO:0010824)	3.68037370
34	nodal signaling pathway (GO:0038092)	3.63858726
35	DNA strand elongation (GO:0022616)	3.60828186
36	DNA strand elongation involved in DNA replication (GO:0006271)	3.59699109
37	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.55975025
38	histone H2A acetylation (GO:0043968)	3.54651722
39	double-strand break repair via homologous recombination (GO:0000724)	3.53335650
40	ubiquinone metabolic process (GO:0006743)	3.49270796
41	telomere maintenance via semi-conservative replication (GO:0032201)	3.48175887
42	recombinational repair (GO:0000725)	3.46170139
43	nucleobase biosynthetic process (GO:0046112)	3.45980230
44	protein K6-linked ubiquitination (GO:0085020)	3.45703735
45	serine family amino acid biosynthetic process (GO:0009070)	3.45418039
46	centriole replication (GO:0007099)	3.44327460
47	translesion synthesis (GO:0019985)	3.39766712
48	homocysteine metabolic process (GO:0050667)	3.36492373
49	nuclear pore complex assembly (GO:0051292)	3.31299589
50	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.29269572
51	axon extension involved in axon guidance (GO:0048846)	3.29269572
52	negative regulation of axon guidance (GO:1902668)	3.23668495
53	telomere maintenance via recombination (GO:0000722)	3.22541125
54	purine nucleobase biosynthetic process (GO:0009113)	3.21155380
55	DNA replication initiation (GO:0006270)	3.20776555
56	postreplication repair (GO:0006301)	3.20201998
57	protein polyglutamylation (GO:0018095)	3.19646733
58	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.18377271
59	somatic diversification of immunoglobulins (GO:0016445)	3.16574043
60	mitotic recombination (GO:0006312)	3.12259958
61	quinone biosynthetic process (GO:1901663)	3.05459633
62	DNA catabolic process, exonucleolytic (GO:0000738)	3.04966221
63	histone H3-K9 demethylation (GO:0033169)	3.04685951
64	retinal rod cell development (GO:0046548)	3.04458237
65	regulation of DNA recombination (GO:0000018)	3.04404147
66	ribosome assembly (GO:0042255)	3.04057866
67	mitotic nuclear envelope disassembly (GO:0007077)	3.01623613
68	DNA-dependent DNA replication (GO:0006261)	3.00706470
69	nuclear pore organization (GO:0006999)	2.97126149
70	ncRNA 3-end processing (GO:0043628)	2.96527916
71	protein localization to chromosome (GO:0034502)	2.92832713
72	photoreceptor cell development (GO:0042461)	2.91191227
73	protein-cofactor linkage (GO:0018065)	2.90818071
74	retinal ganglion cell axon guidance (GO:0031290)	2.87650302
75	retinal cone cell development (GO:0046549)	2.87456129
76	ribosomal small subunit assembly (GO:0000028)	2.87246396
77	eye photoreceptor cell development (GO:0042462)	2.86965379
78	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.86400702
79	somatic cell DNA recombination (GO:0016444)	2.86400702
80	male meiosis (GO:0007140)	2.85729766
81	adaptation of signaling pathway (GO:0023058)	2.85144155
82	IMP biosynthetic process (GO:0006188)	2.84330083
83	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.83573356
84	water-soluble vitamin biosynthetic process (GO:0042364)	2.78224866
85	mitotic G2/M transition checkpoint (GO:0044818)	2.74185156
86	DNA ligation (GO:0006266)	2.73115679
87	double-strand break repair (GO:0006302)	2.73034764
88	response to X-ray (GO:0010165)	2.71200828
89	pyrimidine nucleobase catabolic process (GO:0006208)	2.70770201
90	photoreceptor cell maintenance (GO:0045494)	2.70182651
91	DNA replication checkpoint (GO:0000076)	2.69414863
92	pancreas development (GO:0031016)	2.67478995
93	respiratory chain complex IV assembly (GO:0008535)	2.66728863
94	membrane disassembly (GO:0030397)	2.66450695
95	nuclear envelope disassembly (GO:0051081)	2.66450695
96	positive regulation of meiotic cell cycle (GO:0051446)	2.64608195
97	RNA polyadenylation (GO:0043631)	2.64582086
98	single strand break repair (GO:0000012)	2.64089437
99	meiotic chromosome segregation (GO:0045132)	2.63891519
100	somatic diversification of immune receptors (GO:0002200)	2.63742298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.25037899
2	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.93852720
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70357322
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.66679251
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.37313020
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.34959414
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.29375201
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.78431644
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.77356293
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.76723443
11	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.58259789
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57175991
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42599191
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.37588742
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.24036064
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08816519
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.03637712
18	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.03062782
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.97218050
20	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96149497
21	TP53_16413492_ChIP-PET_HCT116_Human	1.89404052
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86535686
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.86074479
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77119984
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74899009
26	FUS_26573619_Chip-Seq_HEK293_Human	1.74560805
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.74512589
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.73816745
29	EWS_26573619_Chip-Seq_HEK293_Human	1.73488833
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.71307963
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69636754
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.64930167
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.61882300
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60021109
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51800949
36	AR_21909140_ChIP-Seq_LNCAP_Human	1.50221155
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.47943285
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47397055
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46721220
40	P300_19829295_ChIP-Seq_ESCs_Human	1.44922203
41	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41832196
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.41630742
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.39589600
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.38398696
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37267220
46	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.33239754
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.31522650
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28781500
49	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.28560245
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24254267
51	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.23895217
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.23548146
53	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.21766412
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21463043
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.17368449
56	JUN_21703547_ChIP-Seq_K562_Human	1.15809629
57	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.13044397
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12804278
59	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.12631814
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.10973261
61	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.09865817
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08000484
63	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06424692
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05300448
65	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04490768
66	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.04083378
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.04038136
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00156153
69	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00120324
70	FOXP3_21729870_ChIP-Seq_TREG_Human	0.98400430
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97542724
72	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.97392286
73	BCAT_22108803_ChIP-Seq_LS180_Human	0.95684428
74	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.95461775
75	VDR_22108803_ChIP-Seq_LS180_Human	0.94253099
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91890171
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91461043
78	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.91225295
79	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.90773304
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.90492630
81	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.90000947
82	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.88985044
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88887376
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88695564
85	CBP_20019798_ChIP-Seq_JUKART_Human	0.88695564
86	XRN2_22483619_ChIP-Seq_HELA_Human	0.87296931
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87018266
88	TP53_22573176_ChIP-Seq_HFKS_Human	0.86791094
89	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.86168067
90	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.84062844
91	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.83477568
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.83049312
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82229032
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.81220374
95	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.80660407
96	TCF4_23295773_ChIP-Seq_U87_Human	0.80624426
97	WT1_19549856_ChIP-ChIP_CCG9911_Human	0.80440982
98	TP53_18474530_ChIP-ChIP_U2OS_Human	0.77576952
99	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.76818386
100	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.76266305

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	5.43580244
2	MP0009697_abnormal_copulation	5.01638193
3	MP0008058_abnormal_DNA_repair	3.90390154
4	MP0000383_abnormal_hair_follicle	2.97833324
5	MP0002234_abnormal_pharynx_morphology	2.96282942
6	MP0006292_abnormal_olfactory_placode	2.87548520
7	MP0003077_abnormal_cell_cycle	2.58516491
8	MP0003693_abnormal_embryo_hatching	2.55484332
9	MP0008057_abnormal_DNA_replication	2.47090852
10	MP0003111_abnormal_nucleus_morphology	2.43996209
11	MP0006072_abnormal_retinal_apoptosis	2.32155808
12	MP0008995_early_reproductive_senescence	2.24712913
13	MP0008932_abnormal_embryonic_tissue	2.24307204
14	MP0003646_muscle_fatigue	2.22497488
15	MP0004147_increased_porphyrin_level	2.18183459
16	MP0010678_abnormal_skin_adnexa	2.10423568
17	MP0000647_abnormal_sebaceous_gland	2.08234988
18	MP0005083_abnormal_biliary_tract	2.00557939
19	MP0003221_abnormal_cardiomyocyte_apopto	1.95877012
20	MP0003890_abnormal_embryonic-extraembry	1.84366491
21	MP0004957_abnormal_blastocyst_morpholog	1.78800276
22	MP0005248_abnormal_Harderian_gland	1.72066737
23	MP0000427_abnormal_hair_cycle	1.64577204
24	MP0004233_abnormal_muscle_weight	1.63956819
25	MP0004197_abnormal_fetal_growth/weight/	1.60347994
26	MP0001293_anophthalmia	1.55305138
27	MP0005360_urolithiasis	1.55155296
28	MP0002837_dystrophic_cardiac_calcinosis	1.54576517
29	MP0005253_abnormal_eye_physiology	1.54423452
30	MP0008877_abnormal_DNA_methylation	1.49549243
31	MP0000358_abnormal_cell_content/	1.43746121
32	MP0002638_abnormal_pupillary_reflex	1.38804242
33	MP0003119_abnormal_digestive_system	1.33357906
34	MP0002751_abnormal_autonomic_nervous	1.32407139
35	MP0004484_altered_response_of	1.32013095
36	MP0008007_abnormal_cellular_replicative	1.31760977
37	MP0004084_abnormal_cardiac_muscle	1.30046994
38	MP0003136_yellow_coat_color	1.28803367
39	MP0003656_abnormal_erythrocyte_physiolo	1.26143894
40	MP0000631_abnormal_neuroendocrine_gland	1.26077026
41	MP0005187_abnormal_penis_morphology	1.23952415
42	MP0006138_congestive_heart_failure	1.20453000
43	MP0004133_heterotaxia	1.20097545
44	MP0001929_abnormal_gametogenesis	1.16932135
45	MP0008789_abnormal_olfactory_epithelium	1.16029541
46	MP0003786_premature_aging	1.15978505
47	MP0000015_abnormal_ear_pigmentation	1.14935003
48	MP0002210_abnormal_sex_determination	1.09578649
49	MP0003937_abnormal_limbs/digits/tail_de	1.09552649
50	MP0003868_abnormal_feces_composition	1.08555239
51	MP0005551_abnormal_eye_electrophysiolog	1.06324013
52	MP0008775_abnormal_heart_ventricle	1.06206659
53	MP0002009_preneoplasia	1.05156728
54	MP0003186_abnormal_redox_activity	1.02849521
55	MP0000516_abnormal_urinary_system	0.99688668
56	MP0005367_renal/urinary_system_phenotyp	0.99688668
57	MP0010307_abnormal_tumor_latency	0.99186022
58	MP0003718_maternal_effect	0.96846210
59	MP0001145_abnormal_male_reproductive	0.96478704
60	MP0005499_abnormal_olfactory_system	0.96391961
61	MP0005394_taste/olfaction_phenotype	0.96391961
62	MP0003698_abnormal_male_reproductive	0.96284992
63	MP0000350_abnormal_cell_proliferation	0.95269963
64	MP0000653_abnormal_sex_gland	0.93991578
65	MP0001764_abnormal_homeostasis	0.93964941
66	MP0003984_embryonic_growth_retardation	0.93070506
67	MP0001697_abnormal_embryo_size	0.92881541
68	MP0002088_abnormal_embryonic_growth/wei	0.92185475
69	MP0005380_embryogenesis_phenotype	0.91785849
70	MP0001672_abnormal_embryogenesis/_devel	0.91785849
71	MP0001661_extended_life_span	0.90480087
72	MP0005647_abnormal_sex_gland	0.89333431
73	MP0001119_abnormal_female_reproductive	0.88911238
74	MP0002084_abnormal_developmental_patter	0.87981089
75	MP0002102_abnormal_ear_morphology	0.86797126
76	MP0002085_abnormal_embryonic_tissue	0.86635824
77	MP0002098_abnormal_vibrissa_morphology	0.85699695
78	MP0001324_abnormal_eye_pigmentation	0.85361933
79	MP0002080_prenatal_lethality	0.85247499
80	MP0003195_calcinosis	0.83086814
81	MP0004215_abnormal_myocardial_fiber	0.83013731
82	MP0000313_abnormal_cell_death	0.82787755
83	MP0005391_vision/eye_phenotype	0.82398742
84	MP0005220_abnormal_exocrine_pancreas	0.81497565
85	MP0003942_abnormal_urinary_system	0.81196985
86	MP0003137_abnormal_impulse_conducting	0.80725341
87	MP0000569_abnormal_digit_pigmentation	0.80072384
88	MP0003878_abnormal_ear_physiology	0.79498669
89	MP0005377_hearing/vestibular/ear_phenot	0.79498669
90	MP0002697_abnormal_eye_size	0.79135920
91	MP0001529_abnormal_vocalization	0.78334731
92	MP0004019_abnormal_vitamin_homeostasis	0.77863581
93	MP0002909_abnormal_adrenal_gland	0.77617646
94	MP0005266_abnormal_metabolism	0.77270071
95	MP0002233_abnormal_nose_morphology	0.75838182
96	MP0010352_gastrointestinal_tract_polyps	0.75545242
97	MP0006035_abnormal_mitochondrial_morpho	0.69121137
98	MP0000377_abnormal_hair_follicle	0.69003641
99	MP0005310_abnormal_salivary_gland	0.68748681
100	MP0002086_abnormal_extraembryonic_tissu	0.67177402

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	5.26917182
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.80892117
3	Mesangial abnormality (HP:0001966)	4.47072610
4	Hypoplasia of the thymus (HP:0000778)	4.43944646
5	Abnormality of chromosome stability (HP:0003220)	4.26616788
6	Chromsome breakage (HP:0040012)	4.19877719
7	Hyperglycinemia (HP:0002154)	4.17686999
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.02997478
9	Meckel diverticulum (HP:0002245)	3.95748820
10	Abnormality of the ileum (HP:0001549)	3.76258331
11	Abnormality of the renal cortex (HP:0011035)	3.54407452
12	Ependymoma (HP:0002888)	3.28115842
13	Abnormality of the preputium (HP:0100587)	3.23827341
14	Hyperglycinuria (HP:0003108)	3.08631801
15	Squamous cell carcinoma (HP:0002860)	3.07621628
16	Fair hair (HP:0002286)	3.07523598
17	Abnormality of serine family amino acid metabolism (HP:0010894)	3.06158978
18	Abnormality of glycine metabolism (HP:0010895)	3.06158978
19	Birth length less than 3rd percentile (HP:0003561)	3.00344853
20	Astrocytoma (HP:0009592)	2.93917013
21	Abnormality of the astrocytes (HP:0100707)	2.93917013
22	Abnormality of the carotid arteries (HP:0005344)	2.91152214
23	Agnosia (HP:0010524)	2.86961426
24	Glioma (HP:0009733)	2.73580161
25	Median cleft lip (HP:0000161)	2.70984130
26	Depressed nasal tip (HP:0000437)	2.68901002
27	Small intestinal stenosis (HP:0012848)	2.66634999
28	Duodenal stenosis (HP:0100867)	2.66634999
29	Clitoromegaly (HP:0000057)	2.62411376
30	Abnormal cartilage morphology (HP:0002763)	2.62283016
31	Congenital, generalized hypertrichosis (HP:0004540)	2.60765026
32	Clubbing of toes (HP:0100760)	2.51948583
33	Medulloblastoma (HP:0002885)	2.51026247
34	Abnormality of the labia minora (HP:0012880)	2.49523995
35	Abnormality of glycolysis (HP:0004366)	2.44705218
36	Abnormality of the anterior horn cell (HP:0006802)	2.42344916
37	Degeneration of anterior horn cells (HP:0002398)	2.42344916
38	Neoplasm of the adrenal cortex (HP:0100641)	2.39532019
39	Increased serum pyruvate (HP:0003542)	2.38865080
40	Hyperventilation (HP:0002883)	2.36723779
41	Abnormality of the duodenum (HP:0002246)	2.36288589
42	Cone-rod dystrophy (HP:0000548)	2.33395414
43	Dry hair (HP:0011359)	2.31750835
44	Tubulointerstitial nephritis (HP:0001970)	2.31492001
45	Ectopic kidney (HP:0000086)	2.29770578
46	Neoplasm of the oral cavity (HP:0100649)	2.28766007
47	Volvulus (HP:0002580)	2.26938967
48	Cafe-au-lait spot (HP:0000957)	2.25830232
49	Abnormality of the nasal septum (HP:0000419)	2.24882760
50	Carpal bone hypoplasia (HP:0001498)	2.24206733
51	Partial agenesis of the corpus callosum (HP:0001338)	2.22453566
52	Facial cleft (HP:0002006)	2.21775512
53	Triphalangeal thumb (HP:0001199)	2.20181930
54	Multiple enchondromatosis (HP:0005701)	2.19558200
55	Abnormal tarsal ossification (HP:0008369)	2.18017692
56	Nephronophthisis (HP:0000090)	2.16509726
57	Sloping forehead (HP:0000340)	2.15657668
58	Pancreatic cysts (HP:0001737)	2.15279415
59	Abnormal hair whorl (HP:0010721)	2.12238822
60	Aplasia cutis congenita (HP:0001057)	2.10063085
61	Azoospermia (HP:0000027)	2.09932867
62	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.08987489
63	Myelodysplasia (HP:0002863)	2.08653427
64	Chronic hepatic failure (HP:0100626)	2.08049774
65	Septo-optic dysplasia (HP:0100842)	2.06557821
66	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	2.04094320
67	Small epiphyses (HP:0010585)	2.03047284
68	Ankyloglossia (HP:0010296)	2.03008655
69	Hypoplasia of the pons (HP:0012110)	2.01206582
70	Abnormal pancreas size (HP:0012094)	1.98534467
71	Asplenia (HP:0001746)	1.97103473
72	Abnormal biliary tract morphology (HP:0012440)	1.96977356
73	Freckling (HP:0001480)	1.92997042
74	Neonatal respiratory distress (HP:0002643)	1.90401825
75	Abnormality of the renal medulla (HP:0100957)	1.89720257
76	Thyroiditis (HP:0100646)	1.89103537
77	Rhabdomyosarcoma (HP:0002859)	1.88746731
78	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.88098406
79	Generalized hypopigmentation of hair (HP:0011358)	1.86620595
80	Arteriovenous malformation (HP:0100026)	1.86332702
81	Hypoplastic labia majora (HP:0000059)	1.85497619
82	Woolly hair (HP:0002224)	1.84418985
83	IgM deficiency (HP:0002850)	1.84341192
84	B lymphocytopenia (HP:0010976)	1.82711638
85	Acute myeloid leukemia (HP:0004808)	1.79023719
86	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.78968054
87	Astigmatism (HP:0000483)	1.78021113
88	Fibular aplasia (HP:0002990)	1.77833837
89	Absent radius (HP:0003974)	1.76600153
90	Abnormality of the pons (HP:0007361)	1.75471737
91	Abnormal foot bone ossification (HP:0010675)	1.73982346
92	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.73721977
93	Abnormality of the labia majora (HP:0012881)	1.72815838
94	Abnormality of B cell number (HP:0010975)	1.71714992
95	Hypotelorism (HP:0000601)	1.71017749
96	Abnormality of serum amino acid levels (HP:0003112)	1.70909991
97	Proximal tubulopathy (HP:0000114)	1.70764164
98	Limb hypertonia (HP:0002509)	1.69022441
99	Absent forearm bone (HP:0003953)	1.68822027
100	Aplasia involving forearm bones (HP:0009822)	1.68822027

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	5.34371570
2	TNIK	5.12621830
3	BMPR1B	4.88607603
4	TTK	3.19622782
5	BRSK2	2.73717017
6	EPHA3	2.68444434
7	ZAK	2.59893167
8	PLK4	2.48160518
9	NEK1	2.35268927
10	MAP4K2	2.34125168
11	SRPK1	2.30664136
12	CDC7	2.10172691
13	FRK	1.85458773
14	TSSK6	1.69449889
15	PLK3	1.64654215
16	CHEK2	1.63626191
17	WNK3	1.62303796
18	VRK1	1.61463131
19	NLK	1.58088671
20	ATR	1.52732788
21	PLK2	1.52518030
22	BRD4	1.52321265
23	WEE1	1.49735293
24	BCKDK	1.47158186
25	MST4	1.37763526
26	BRSK1	1.33869469
27	CAMK1D	1.31644542
28	EIF2AK1	1.29961222
29	MARK3	1.24879424
30	SIK3	1.22543345
31	NEK9	1.22405084
32	NTRK1	1.20669059
33	IRAK1	1.13767955
34	NTRK2	1.08416840
35	TGFBR1	1.08054550
36	MKNK2	1.07284413
37	BUB1	1.03064072
38	RPS6KA4	0.97765786
39	ATM	0.91683535
40	YES1	0.89864754
41	MAPKAPK5	0.87250453
42	FLT3	0.85345699
43	AKT3	0.85212619
44	PLK1	0.81413447
45	BCR	0.80175639
46	CAMK1G	0.79092814
47	CDK8	0.73209928
48	CHEK1	0.70613127
49	NEK6	0.68576786
50	CAMKK2	0.67279843
51	PIM2	0.65426112
52	PAK6	0.62232907
53	PDK2	0.59714307
54	PRKCE	0.59614825
55	ERBB4	0.59525116
56	CSNK1A1L	0.58821009
57	NME1	0.57969171
58	CDK7	0.56652463
59	CDK9	0.56453415
60	CDK1	0.55611888
61	CSNK1D	0.55358663
62	TYRO3	0.54828977
63	FGFR1	0.52196086
64	PRKCI	0.50382832
65	ACVR1B	0.50081535
66	EIF2AK2	0.49911834
67	DYRK3	0.49868038
68	CSNK1G3	0.48897609
69	PBK	0.48518091
70	OBSCN	0.48319398
71	DYRK2	0.47812198
72	STK3	0.47356079
73	SIK1	0.47137401
74	CDK3	0.44266062
75	FER	0.44132541
76	CSNK1G1	0.41981436
77	MAP3K5	0.41545732
78	MAPK11	0.40763921
79	WNK1	0.40631946
80	PRKDC	0.40414901
81	MKNK1	0.40187450
82	CDK2	0.40091908
83	TLK1	0.39384090
84	ALK	0.39249332
85	WNK4	0.39200786
86	GSK3B	0.39056633
87	CDK6	0.38397678
88	PTK2B	0.38353606
89	STK39	0.36448011
90	KSR1	0.35707130
91	AURKB	0.35522367
92	ADRBK1	0.35443612
93	RPS6KA5	0.35114813
94	MET	0.34086816
95	BMPR2	0.33403719
96	PRKACB	0.31547585
97	PRKAA1	0.30752295
98	MAPK10	0.27913466
99	PIM1	0.26526007
100	CSNK2A2	0.26350734

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	4.22772348
2	Mismatch repair_Homo sapiens_hsa03430	3.98122005
3	Homologous recombination_Homo sapiens_hsa03440	3.88499794
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.61827548
5	Non-homologous end-joining_Homo sapiens_hsa03450	3.45627571
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.11622275
7	DNA replication_Homo sapiens_hsa03030	3.00385467
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.77403655
9	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.58947373
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.57078617
11	Base excision repair_Homo sapiens_hsa03410	2.49194983
12	Propanoate metabolism_Homo sapiens_hsa00640	2.45307448
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.19992709
14	One carbon pool by folate_Homo sapiens_hsa00670	2.12677341
15	Nitrogen metabolism_Homo sapiens_hsa00910	2.06887413
16	Basal transcription factors_Homo sapiens_hsa03022	2.04877293
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.92551559
18	Cell cycle_Homo sapiens_hsa04110	1.86820251
19	RNA degradation_Homo sapiens_hsa03018	1.77807454
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.69881601
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.63667056
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.59391982
23	Spliceosome_Homo sapiens_hsa03040	1.55249890
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.49219036
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.47489890
26	RNA transport_Homo sapiens_hsa03013	1.43793225
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.42763138
28	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.42660332
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.34693787
30	ABC transporters_Homo sapiens_hsa02010	1.22288988
31	Carbon metabolism_Homo sapiens_hsa01200	1.19925599
32	RNA polymerase_Homo sapiens_hsa03020	1.11998518
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10087353
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.09271187
35	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.07716656
36	Proteasome_Homo sapiens_hsa03050	1.01557326
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.01361211
38	Butanoate metabolism_Homo sapiens_hsa00650	1.00932335
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00118757
40	Folate biosynthesis_Homo sapiens_hsa00790	0.99364309
41	Arginine and proline metabolism_Homo sapiens_hsa00330	0.99082065
42	Protein export_Homo sapiens_hsa03060	0.96255502
43	Phototransduction_Homo sapiens_hsa04744	0.94345633
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.92925158
45	Purine metabolism_Homo sapiens_hsa00230	0.91702934
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.88441864
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87475431
48	Lysine degradation_Homo sapiens_hsa00310	0.85858809
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79938485
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.78083734
51	p53 signaling pathway_Homo sapiens_hsa04115	0.70361837
52	Alcoholism_Homo sapiens_hsa05034	0.66819253
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66475165
54	Fatty acid elongation_Homo sapiens_hsa00062	0.63418128
55	Peroxisome_Homo sapiens_hsa04146	0.62971982
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.61655131
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56690750
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56198346
59	Tight junction_Homo sapiens_hsa04530	0.54565906
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.51400179
61	Oocyte meiosis_Homo sapiens_hsa04114	0.50937230
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.48501392
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45895284
64	Glutathione metabolism_Homo sapiens_hsa00480	0.45222218
65	MicroRNAs in cancer_Homo sapiens_hsa05206	0.41934350
66	Metabolic pathways_Homo sapiens_hsa01100	0.41515370
67	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.41201069
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40587870
69	Histidine metabolism_Homo sapiens_hsa00340	0.40036160
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.39357839
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.35919618
72	Colorectal cancer_Homo sapiens_hsa05210	0.35667161
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.35180455
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.32807956
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.32315919
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31096022
77	Taste transduction_Homo sapiens_hsa04742	0.30520316
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.30391122
79	Axon guidance_Homo sapiens_hsa04360	0.29972181
80	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29608244
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29530318
82	Huntingtons disease_Homo sapiens_hsa05016	0.26007851
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25703611
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25515219
85	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.24844895
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24557697
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.22616533
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22204245
89	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.21831011
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.20993212
91	Thyroid cancer_Homo sapiens_hsa05216	0.20229241
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.18116368
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.16871372
94	Legionellosis_Homo sapiens_hsa05134	0.15063385
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.13983178
96	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.13917700
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.12971142
98	Retinol metabolism_Homo sapiens_hsa00830	0.12877069
99	Pentose phosphate pathway_Homo sapiens_hsa00030	0.10759864
100	Type II diabetes mellitus_Homo sapiens_hsa04930	0.08278426

PPIHP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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