PPIHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)8.22958331
2replication fork processing (GO:0031297)7.56107231
3somatic diversification of immune receptors via somatic mutation (GO:0002566)6.35517062
4somatic hypermutation of immunoglobulin genes (GO:0016446)6.35517062
5maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.09767160
6DNA strand renaturation (GO:0000733)5.89654718
7kinetochore organization (GO:0051383)5.88224149
8negative regulation of DNA recombination (GO:0045910)5.86763187
9kinetochore assembly (GO:0051382)5.68334920
10regulation of double-strand break repair via homologous recombination (GO:0010569)5.45693110
11negative regulation of DNA-dependent DNA replication (GO:2000104)4.95715349
12L-serine metabolic process (GO:0006563)4.51291926
13protein prenylation (GO:0018342)4.25849070
14prenylation (GO:0097354)4.25849070
15biotin metabolic process (GO:0006768)4.18959015
16somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.15393982
17isotype switching (GO:0045190)4.15393982
18somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.15393982
19ER overload response (GO:0006983)4.14128061
20DNA double-strand break processing (GO:0000729)4.05982881
21mitotic chromosome condensation (GO:0007076)3.89587414
22sister chromatid cohesion (GO:0007062)3.89508088
23signal peptide processing (GO:0006465)3.85659676
24mismatch repair (GO:0006298)3.79761697
25DNA replication-dependent nucleosome assembly (GO:0006335)3.78814494
26DNA replication-dependent nucleosome organization (GO:0034723)3.78814494
27regulation of centriole replication (GO:0046599)3.78671643
28ubiquinone biosynthetic process (GO:0006744)3.76173136
29regulation of helicase activity (GO:0051095)3.75211460
30regulation of centrosome cycle (GO:0046605)3.73848177
31reciprocal DNA recombination (GO:0035825)3.69225268
32reciprocal meiotic recombination (GO:0007131)3.69225268
33regulation of centrosome duplication (GO:0010824)3.68037370
34nodal signaling pathway (GO:0038092)3.63858726
35DNA strand elongation (GO:0022616)3.60828186
36DNA strand elongation involved in DNA replication (GO:0006271)3.59699109
37somatic recombination of immunoglobulin gene segments (GO:0016447)3.55975025
38histone H2A acetylation (GO:0043968)3.54651722
39double-strand break repair via homologous recombination (GO:0000724)3.53335650
40ubiquinone metabolic process (GO:0006743)3.49270796
41telomere maintenance via semi-conservative replication (GO:0032201)3.48175887
42recombinational repair (GO:0000725)3.46170139
43nucleobase biosynthetic process (GO:0046112)3.45980230
44protein K6-linked ubiquitination (GO:0085020)3.45703735
45serine family amino acid biosynthetic process (GO:0009070)3.45418039
46centriole replication (GO:0007099)3.44327460
47translesion synthesis (GO:0019985)3.39766712
48homocysteine metabolic process (GO:0050667)3.36492373
49nuclear pore complex assembly (GO:0051292)3.31299589
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.29269572
51axon extension involved in axon guidance (GO:0048846)3.29269572
52negative regulation of axon guidance (GO:1902668)3.23668495
53telomere maintenance via recombination (GO:0000722)3.22541125
54purine nucleobase biosynthetic process (GO:0009113)3.21155380
55DNA replication initiation (GO:0006270)3.20776555
56postreplication repair (GO:0006301)3.20201998
57protein polyglutamylation (GO:0018095)3.19646733
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.18377271
59somatic diversification of immunoglobulins (GO:0016445)3.16574043
60mitotic recombination (GO:0006312)3.12259958
61quinone biosynthetic process (GO:1901663)3.05459633
62DNA catabolic process, exonucleolytic (GO:0000738)3.04966221
63histone H3-K9 demethylation (GO:0033169)3.04685951
64retinal rod cell development (GO:0046548)3.04458237
65regulation of DNA recombination (GO:0000018)3.04404147
66ribosome assembly (GO:0042255)3.04057866
67mitotic nuclear envelope disassembly (GO:0007077)3.01623613
68DNA-dependent DNA replication (GO:0006261)3.00706470
69nuclear pore organization (GO:0006999)2.97126149
70ncRNA 3-end processing (GO:0043628)2.96527916
71protein localization to chromosome (GO:0034502)2.92832713
72photoreceptor cell development (GO:0042461)2.91191227
73protein-cofactor linkage (GO:0018065)2.90818071
74retinal ganglion cell axon guidance (GO:0031290)2.87650302
75retinal cone cell development (GO:0046549)2.87456129
76ribosomal small subunit assembly (GO:0000028)2.87246396
77eye photoreceptor cell development (GO:0042462)2.86965379
78somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.86400702
79somatic cell DNA recombination (GO:0016444)2.86400702
80male meiosis (GO:0007140)2.85729766
81adaptation of signaling pathway (GO:0023058)2.85144155
82IMP biosynthetic process (GO:0006188)2.84330083
83cell fate commitment involved in formation of primary germ layer (GO:0060795)2.83573356
84water-soluble vitamin biosynthetic process (GO:0042364)2.78224866
85mitotic G2/M transition checkpoint (GO:0044818)2.74185156
86DNA ligation (GO:0006266)2.73115679
87double-strand break repair (GO:0006302)2.73034764
88response to X-ray (GO:0010165)2.71200828
89pyrimidine nucleobase catabolic process (GO:0006208)2.70770201
90photoreceptor cell maintenance (GO:0045494)2.70182651
91DNA replication checkpoint (GO:0000076)2.69414863
92pancreas development (GO:0031016)2.67478995
93respiratory chain complex IV assembly (GO:0008535)2.66728863
94membrane disassembly (GO:0030397)2.66450695
95nuclear envelope disassembly (GO:0051081)2.66450695
96positive regulation of meiotic cell cycle (GO:0051446)2.64608195
97RNA polyadenylation (GO:0043631)2.64582086
98single strand break repair (GO:0000012)2.64089437
99meiotic chromosome segregation (GO:0045132)2.63891519
100somatic diversification of immune receptors (GO:0002200)2.63742298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25037899
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.93852720
3ZNF274_21170338_ChIP-Seq_K562_Hela3.70357322
4TAF15_26573619_Chip-Seq_HEK293_Human3.66679251
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.37313020
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34959414
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.29375201
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.78431644
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.77356293
10ELK1_19687146_ChIP-ChIP_HELA_Human2.76723443
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58259789
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.57175991
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42599191
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37588742
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24036064
16IGF1R_20145208_ChIP-Seq_DFB_Human2.08816519
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.03637712
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.03062782
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97218050
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96149497
21TP53_16413492_ChIP-PET_HCT116_Human1.89404052
22IRF1_19129219_ChIP-ChIP_H3396_Human1.86535686
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86074479
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77119984
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.74899009
26FUS_26573619_Chip-Seq_HEK293_Human1.74560805
27VDR_23849224_ChIP-Seq_CD4+_Human1.74512589
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73816745
29EWS_26573619_Chip-Seq_HEK293_Human1.73488833
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.71307963
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69636754
32GBX2_23144817_ChIP-Seq_PC3_Human1.64930167
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61882300
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60021109
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51800949
36AR_21909140_ChIP-Seq_LNCAP_Human1.50221155
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47943285
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47397055
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46721220
40P300_19829295_ChIP-Seq_ESCs_Human1.44922203
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41832196
42DCP1A_22483619_ChIP-Seq_HELA_Human1.41630742
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39589600
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.38398696
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37267220
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33239754
47MYC_18940864_ChIP-ChIP_HL60_Human1.31522650
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28781500
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28560245
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24254267
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23895217
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23548146
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21766412
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21463043
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17368449
56JUN_21703547_ChIP-Seq_K562_Human1.15809629
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.13044397
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12804278
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12631814
60TTF2_22483619_ChIP-Seq_HELA_Human1.10973261
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09865817
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08000484
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06424692
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.05300448
65KDM5A_27292631_Chip-Seq_BREAST_Human1.04490768
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04083378
67GABP_19822575_ChIP-Seq_HepG2_Human1.04038136
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.00156153
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.00120324
70FOXP3_21729870_ChIP-Seq_TREG_Human0.98400430
71EZH2_27294783_Chip-Seq_NPCs_Mouse0.97542724
72PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97392286
73BCAT_22108803_ChIP-Seq_LS180_Human0.95684428
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95461775
75VDR_22108803_ChIP-Seq_LS180_Human0.94253099
76HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91890171
77THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91461043
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91225295
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90773304
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90492630
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90000947
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88985044
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.88887376
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88695564
85CBP_20019798_ChIP-Seq_JUKART_Human0.88695564
86XRN2_22483619_ChIP-Seq_HELA_Human0.87296931
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87018266
88TP53_22573176_ChIP-Seq_HFKS_Human0.86791094
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86168067
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.84062844
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83477568
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83049312
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82229032
94ER_23166858_ChIP-Seq_MCF-7_Human0.81220374
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.80660407
96TCF4_23295773_ChIP-Seq_U87_Human0.80624426
97WT1_19549856_ChIP-ChIP_CCG9911_Human0.80440982
98TP53_18474530_ChIP-ChIP_U2OS_Human0.77576952
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76818386
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76266305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.43580244
2MP0009697_abnormal_copulation5.01638193
3MP0008058_abnormal_DNA_repair3.90390154
4MP0000383_abnormal_hair_follicle2.97833324
5MP0002234_abnormal_pharynx_morphology2.96282942
6MP0006292_abnormal_olfactory_placode2.87548520
7MP0003077_abnormal_cell_cycle2.58516491
8MP0003693_abnormal_embryo_hatching2.55484332
9MP0008057_abnormal_DNA_replication2.47090852
10MP0003111_abnormal_nucleus_morphology2.43996209
11MP0006072_abnormal_retinal_apoptosis2.32155808
12MP0008995_early_reproductive_senescence2.24712913
13MP0008932_abnormal_embryonic_tissue2.24307204
14MP0003646_muscle_fatigue2.22497488
15MP0004147_increased_porphyrin_level2.18183459
16MP0010678_abnormal_skin_adnexa2.10423568
17MP0000647_abnormal_sebaceous_gland2.08234988
18MP0005083_abnormal_biliary_tract2.00557939
19MP0003221_abnormal_cardiomyocyte_apopto1.95877012
20MP0003890_abnormal_embryonic-extraembry1.84366491
21MP0004957_abnormal_blastocyst_morpholog1.78800276
22MP0005248_abnormal_Harderian_gland1.72066737
23MP0000427_abnormal_hair_cycle1.64577204
24MP0004233_abnormal_muscle_weight1.63956819
25MP0004197_abnormal_fetal_growth/weight/1.60347994
26MP0001293_anophthalmia1.55305138
27MP0005360_urolithiasis1.55155296
28MP0002837_dystrophic_cardiac_calcinosis1.54576517
29MP0005253_abnormal_eye_physiology1.54423452
30MP0008877_abnormal_DNA_methylation1.49549243
31MP0000358_abnormal_cell_content/1.43746121
32MP0002638_abnormal_pupillary_reflex1.38804242
33MP0003119_abnormal_digestive_system1.33357906
34MP0002751_abnormal_autonomic_nervous1.32407139
35MP0004484_altered_response_of1.32013095
36MP0008007_abnormal_cellular_replicative1.31760977
37MP0004084_abnormal_cardiac_muscle1.30046994
38MP0003136_yellow_coat_color1.28803367
39MP0003656_abnormal_erythrocyte_physiolo1.26143894
40MP0000631_abnormal_neuroendocrine_gland1.26077026
41MP0005187_abnormal_penis_morphology1.23952415
42MP0006138_congestive_heart_failure1.20453000
43MP0004133_heterotaxia1.20097545
44MP0001929_abnormal_gametogenesis1.16932135
45MP0008789_abnormal_olfactory_epithelium1.16029541
46MP0003786_premature_aging1.15978505
47MP0000015_abnormal_ear_pigmentation1.14935003
48MP0002210_abnormal_sex_determination1.09578649
49MP0003937_abnormal_limbs/digits/tail_de1.09552649
50MP0003868_abnormal_feces_composition1.08555239
51MP0005551_abnormal_eye_electrophysiolog1.06324013
52MP0008775_abnormal_heart_ventricle1.06206659
53MP0002009_preneoplasia1.05156728
54MP0003186_abnormal_redox_activity1.02849521
55MP0000516_abnormal_urinary_system0.99688668
56MP0005367_renal/urinary_system_phenotyp0.99688668
57MP0010307_abnormal_tumor_latency0.99186022
58MP0003718_maternal_effect0.96846210
59MP0001145_abnormal_male_reproductive0.96478704
60MP0005499_abnormal_olfactory_system0.96391961
61MP0005394_taste/olfaction_phenotype0.96391961
62MP0003698_abnormal_male_reproductive0.96284992
63MP0000350_abnormal_cell_proliferation0.95269963
64MP0000653_abnormal_sex_gland0.93991578
65MP0001764_abnormal_homeostasis0.93964941
66MP0003984_embryonic_growth_retardation0.93070506
67MP0001697_abnormal_embryo_size0.92881541
68MP0002088_abnormal_embryonic_growth/wei0.92185475
69MP0005380_embryogenesis_phenotype0.91785849
70MP0001672_abnormal_embryogenesis/_devel0.91785849
71MP0001661_extended_life_span0.90480087
72MP0005647_abnormal_sex_gland0.89333431
73MP0001119_abnormal_female_reproductive0.88911238
74MP0002084_abnormal_developmental_patter0.87981089
75MP0002102_abnormal_ear_morphology0.86797126
76MP0002085_abnormal_embryonic_tissue0.86635824
77MP0002098_abnormal_vibrissa_morphology0.85699695
78MP0001324_abnormal_eye_pigmentation0.85361933
79MP0002080_prenatal_lethality0.85247499
80MP0003195_calcinosis0.83086814
81MP0004215_abnormal_myocardial_fiber0.83013731
82MP0000313_abnormal_cell_death0.82787755
83MP0005391_vision/eye_phenotype0.82398742
84MP0005220_abnormal_exocrine_pancreas0.81497565
85MP0003942_abnormal_urinary_system0.81196985
86MP0003137_abnormal_impulse_conducting0.80725341
87MP0000569_abnormal_digit_pigmentation0.80072384
88MP0003878_abnormal_ear_physiology0.79498669
89MP0005377_hearing/vestibular/ear_phenot0.79498669
90MP0002697_abnormal_eye_size0.79135920
91MP0001529_abnormal_vocalization0.78334731
92MP0004019_abnormal_vitamin_homeostasis0.77863581
93MP0002909_abnormal_adrenal_gland0.77617646
94MP0005266_abnormal_metabolism0.77270071
95MP0002233_abnormal_nose_morphology0.75838182
96MP0010352_gastrointestinal_tract_polyps0.75545242
97MP0006035_abnormal_mitochondrial_morpho0.69121137
98MP0000377_abnormal_hair_follicle0.69003641
99MP0005310_abnormal_salivary_gland0.68748681
100MP0002086_abnormal_extraembryonic_tissu0.67177402

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)5.26917182
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.80892117
3Mesangial abnormality (HP:0001966)4.47072610
4Hypoplasia of the thymus (HP:0000778)4.43944646
5Abnormality of chromosome stability (HP:0003220)4.26616788
6Chromsome breakage (HP:0040012)4.19877719
7Hyperglycinemia (HP:0002154)4.17686999
8Aplasia/Hypoplasia of the uvula (HP:0010293)4.02997478
9Meckel diverticulum (HP:0002245)3.95748820
10Abnormality of the ileum (HP:0001549)3.76258331
11Abnormality of the renal cortex (HP:0011035)3.54407452
12Ependymoma (HP:0002888)3.28115842
13Abnormality of the preputium (HP:0100587)3.23827341
14Hyperglycinuria (HP:0003108)3.08631801
15Squamous cell carcinoma (HP:0002860)3.07621628
16Fair hair (HP:0002286)3.07523598
17Abnormality of serine family amino acid metabolism (HP:0010894)3.06158978
18Abnormality of glycine metabolism (HP:0010895)3.06158978
19Birth length less than 3rd percentile (HP:0003561)3.00344853
20Astrocytoma (HP:0009592)2.93917013
21Abnormality of the astrocytes (HP:0100707)2.93917013
22Abnormality of the carotid arteries (HP:0005344)2.91152214
23Agnosia (HP:0010524)2.86961426
24Glioma (HP:0009733)2.73580161
25Median cleft lip (HP:0000161)2.70984130
26Depressed nasal tip (HP:0000437)2.68901002
27Small intestinal stenosis (HP:0012848)2.66634999
28Duodenal stenosis (HP:0100867)2.66634999
29Clitoromegaly (HP:0000057)2.62411376
30Abnormal cartilage morphology (HP:0002763)2.62283016
31Congenital, generalized hypertrichosis (HP:0004540)2.60765026
32Clubbing of toes (HP:0100760)2.51948583
33Medulloblastoma (HP:0002885)2.51026247
34Abnormality of the labia minora (HP:0012880)2.49523995
35Abnormality of glycolysis (HP:0004366)2.44705218
36Abnormality of the anterior horn cell (HP:0006802)2.42344916
37Degeneration of anterior horn cells (HP:0002398)2.42344916
38Neoplasm of the adrenal cortex (HP:0100641)2.39532019
39Increased serum pyruvate (HP:0003542)2.38865080
40Hyperventilation (HP:0002883)2.36723779
41Abnormality of the duodenum (HP:0002246)2.36288589
42Cone-rod dystrophy (HP:0000548)2.33395414
43Dry hair (HP:0011359)2.31750835
44Tubulointerstitial nephritis (HP:0001970)2.31492001
45Ectopic kidney (HP:0000086)2.29770578
46Neoplasm of the oral cavity (HP:0100649)2.28766007
47Volvulus (HP:0002580)2.26938967
48Cafe-au-lait spot (HP:0000957)2.25830232
49Abnormality of the nasal septum (HP:0000419)2.24882760
50Carpal bone hypoplasia (HP:0001498)2.24206733
51Partial agenesis of the corpus callosum (HP:0001338)2.22453566
52Facial cleft (HP:0002006)2.21775512
53Triphalangeal thumb (HP:0001199)2.20181930
54Multiple enchondromatosis (HP:0005701)2.19558200
55Abnormal tarsal ossification (HP:0008369)2.18017692
56Nephronophthisis (HP:0000090)2.16509726
57Sloping forehead (HP:0000340)2.15657668
58Pancreatic cysts (HP:0001737)2.15279415
59Abnormal hair whorl (HP:0010721)2.12238822
60Aplasia cutis congenita (HP:0001057)2.10063085
61Azoospermia (HP:0000027)2.09932867
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08987489
63Myelodysplasia (HP:0002863)2.08653427
64Chronic hepatic failure (HP:0100626)2.08049774
65Septo-optic dysplasia (HP:0100842)2.06557821
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.04094320
67Small epiphyses (HP:0010585)2.03047284
68Ankyloglossia (HP:0010296)2.03008655
69Hypoplasia of the pons (HP:0012110)2.01206582
70Abnormal pancreas size (HP:0012094)1.98534467
71Asplenia (HP:0001746)1.97103473
72Abnormal biliary tract morphology (HP:0012440)1.96977356
73Freckling (HP:0001480)1.92997042
74Neonatal respiratory distress (HP:0002643)1.90401825
75Abnormality of the renal medulla (HP:0100957)1.89720257
76Thyroiditis (HP:0100646)1.89103537
77Rhabdomyosarcoma (HP:0002859)1.88746731
78Aplasia/Hypoplasia of the thymus (HP:0010515)1.88098406
79Generalized hypopigmentation of hair (HP:0011358)1.86620595
80Arteriovenous malformation (HP:0100026)1.86332702
81Hypoplastic labia majora (HP:0000059)1.85497619
82Woolly hair (HP:0002224)1.84418985
83IgM deficiency (HP:0002850)1.84341192
84B lymphocytopenia (HP:0010976)1.82711638
85Acute myeloid leukemia (HP:0004808)1.79023719
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78968054
87Astigmatism (HP:0000483)1.78021113
88Fibular aplasia (HP:0002990)1.77833837
89Absent radius (HP:0003974)1.76600153
90Abnormality of the pons (HP:0007361)1.75471737
91Abnormal foot bone ossification (HP:0010675)1.73982346
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73721977
93Abnormality of the labia majora (HP:0012881)1.72815838
94Abnormality of B cell number (HP:0010975)1.71714992
95Hypotelorism (HP:0000601)1.71017749
96Abnormality of serum amino acid levels (HP:0003112)1.70909991
97Proximal tubulopathy (HP:0000114)1.70764164
98Limb hypertonia (HP:0002509)1.69022441
99Absent forearm bone (HP:0003953)1.68822027
100Aplasia involving forearm bones (HP:0009822)1.68822027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.34371570
2TNIK5.12621830
3BMPR1B4.88607603
4TTK3.19622782
5BRSK22.73717017
6EPHA32.68444434
7ZAK2.59893167
8PLK42.48160518
9NEK12.35268927
10MAP4K22.34125168
11SRPK12.30664136
12CDC72.10172691
13FRK1.85458773
14TSSK61.69449889
15PLK31.64654215
16CHEK21.63626191
17WNK31.62303796
18VRK11.61463131
19NLK1.58088671
20ATR1.52732788
21PLK21.52518030
22BRD41.52321265
23WEE11.49735293
24BCKDK1.47158186
25MST41.37763526
26BRSK11.33869469
27CAMK1D1.31644542
28EIF2AK11.29961222
29MARK31.24879424
30SIK31.22543345
31NEK91.22405084
32NTRK11.20669059
33IRAK11.13767955
34NTRK21.08416840
35TGFBR11.08054550
36MKNK21.07284413
37BUB11.03064072
38RPS6KA40.97765786
39ATM0.91683535
40YES10.89864754
41MAPKAPK50.87250453
42FLT30.85345699
43AKT30.85212619
44PLK10.81413447
45BCR0.80175639
46CAMK1G0.79092814
47CDK80.73209928
48CHEK10.70613127
49NEK60.68576786
50CAMKK20.67279843
51PIM20.65426112
52PAK60.62232907
53PDK20.59714307
54PRKCE0.59614825
55ERBB40.59525116
56CSNK1A1L0.58821009
57NME10.57969171
58CDK70.56652463
59CDK90.56453415
60CDK10.55611888
61CSNK1D0.55358663
62TYRO30.54828977
63FGFR10.52196086
64PRKCI0.50382832
65ACVR1B0.50081535
66EIF2AK20.49911834
67DYRK30.49868038
68CSNK1G30.48897609
69PBK0.48518091
70OBSCN0.48319398
71DYRK20.47812198
72STK30.47356079
73SIK10.47137401
74CDK30.44266062
75FER0.44132541
76CSNK1G10.41981436
77MAP3K50.41545732
78MAPK110.40763921
79WNK10.40631946
80PRKDC0.40414901
81MKNK10.40187450
82CDK20.40091908
83TLK10.39384090
84ALK0.39249332
85WNK40.39200786
86GSK3B0.39056633
87CDK60.38397678
88PTK2B0.38353606
89STK390.36448011
90KSR10.35707130
91AURKB0.35522367
92ADRBK10.35443612
93RPS6KA50.35114813
94MET0.34086816
95BMPR20.33403719
96PRKACB0.31547585
97PRKAA10.30752295
98MAPK100.27913466
99PIM10.26526007
100CSNK2A20.26350734

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.22772348
2Mismatch repair_Homo sapiens_hsa034303.98122005
3Homologous recombination_Homo sapiens_hsa034403.88499794
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.61827548
5Non-homologous end-joining_Homo sapiens_hsa034503.45627571
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.11622275
7DNA replication_Homo sapiens_hsa030303.00385467
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77403655
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58947373
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57078617
11Base excision repair_Homo sapiens_hsa034102.49194983
12Propanoate metabolism_Homo sapiens_hsa006402.45307448
13Selenocompound metabolism_Homo sapiens_hsa004502.19992709
14One carbon pool by folate_Homo sapiens_hsa006702.12677341
15Nitrogen metabolism_Homo sapiens_hsa009102.06887413
16Basal transcription factors_Homo sapiens_hsa030222.04877293
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92551559
18Cell cycle_Homo sapiens_hsa041101.86820251
19RNA degradation_Homo sapiens_hsa030181.77807454
20Pyruvate metabolism_Homo sapiens_hsa006201.69881601
21Steroid biosynthesis_Homo sapiens_hsa001001.63667056
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59391982
23Spliceosome_Homo sapiens_hsa030401.55249890
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49219036
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47489890
26RNA transport_Homo sapiens_hsa030131.43793225
27Nucleotide excision repair_Homo sapiens_hsa034201.42763138
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42660332
29Fructose and mannose metabolism_Homo sapiens_hsa000511.34693787
30ABC transporters_Homo sapiens_hsa020101.22288988
31Carbon metabolism_Homo sapiens_hsa012001.19925599
32RNA polymerase_Homo sapiens_hsa030201.11998518
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.10087353
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09271187
35Biosynthesis of amino acids_Homo sapiens_hsa012301.07716656
36Proteasome_Homo sapiens_hsa030501.01557326
37Systemic lupus erythematosus_Homo sapiens_hsa053221.01361211
38Butanoate metabolism_Homo sapiens_hsa006501.00932335
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00118757
40Folate biosynthesis_Homo sapiens_hsa007900.99364309
41Arginine and proline metabolism_Homo sapiens_hsa003300.99082065
42Protein export_Homo sapiens_hsa030600.96255502
43Phototransduction_Homo sapiens_hsa047440.94345633
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.92925158
45Purine metabolism_Homo sapiens_hsa002300.91702934
46mRNA surveillance pathway_Homo sapiens_hsa030150.88441864
47Pyrimidine metabolism_Homo sapiens_hsa002400.87475431
48Lysine degradation_Homo sapiens_hsa003100.85858809
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79938485
50Basal cell carcinoma_Homo sapiens_hsa052170.78083734
51p53 signaling pathway_Homo sapiens_hsa041150.70361837
52Alcoholism_Homo sapiens_hsa050340.66819253
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66475165
54Fatty acid elongation_Homo sapiens_hsa000620.63418128
55Peroxisome_Homo sapiens_hsa041460.62971982
56Tryptophan metabolism_Homo sapiens_hsa003800.61655131
57TGF-beta signaling pathway_Homo sapiens_hsa043500.56690750
58Vitamin B6 metabolism_Homo sapiens_hsa007500.56198346
59Tight junction_Homo sapiens_hsa045300.54565906
60Arginine biosynthesis_Homo sapiens_hsa002200.51400179
61Oocyte meiosis_Homo sapiens_hsa041140.50937230
62Fatty acid metabolism_Homo sapiens_hsa012120.48501392
63Hedgehog signaling pathway_Homo sapiens_hsa043400.45895284
64Glutathione metabolism_Homo sapiens_hsa004800.45222218
65MicroRNAs in cancer_Homo sapiens_hsa052060.41934350
66Metabolic pathways_Homo sapiens_hsa011000.41515370
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41201069
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40587870
69Histidine metabolism_Homo sapiens_hsa003400.40036160
70Ether lipid metabolism_Homo sapiens_hsa005650.39357839
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35919618
72Colorectal cancer_Homo sapiens_hsa052100.35667161
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35180455
74Fat digestion and absorption_Homo sapiens_hsa049750.32807956
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32315919
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.31096022
77Taste transduction_Homo sapiens_hsa047420.30520316
78Fatty acid biosynthesis_Homo sapiens_hsa000610.30391122
79Axon guidance_Homo sapiens_hsa043600.29972181
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29608244
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29530318
82Huntingtons disease_Homo sapiens_hsa050160.26007851
83N-Glycan biosynthesis_Homo sapiens_hsa005100.25703611
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25515219
85Chronic myeloid leukemia_Homo sapiens_hsa052200.24844895
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24557697
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22616533
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22204245
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21831011
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20993212
91Thyroid cancer_Homo sapiens_hsa052160.20229241
92Linoleic acid metabolism_Homo sapiens_hsa005910.18116368
93Hippo signaling pathway_Homo sapiens_hsa043900.16871372
94Legionellosis_Homo sapiens_hsa051340.15063385
95Glycerolipid metabolism_Homo sapiens_hsa005610.13983178
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.13917700
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12971142
98Retinol metabolism_Homo sapiens_hsa008300.12877069
99Pentose phosphate pathway_Homo sapiens_hsa000300.10759864
100Type II diabetes mellitus_Homo sapiens_hsa049300.08278426

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »