PPIL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)7.00676435
2regulation of histone H3-K27 methylation (GO:0061085)6.11023642
3DNA deamination (GO:0045006)4.71433308
4ribosomal small subunit assembly (GO:0000028)4.53616593
5telomere maintenance via semi-conservative replication (GO:0032201)4.42311120
6regulation of RNA export from nucleus (GO:0046831)4.40813373
7nuclear pore complex assembly (GO:0051292)4.39373882
8mannose metabolic process (GO:0006013)4.32185102
9DNA strand elongation involved in DNA replication (GO:0006271)4.30121988
10histone H4 deacetylation (GO:0070933)4.26660214
11COPI coating of Golgi vesicle (GO:0048205)4.26369985
12Golgi transport vesicle coating (GO:0048200)4.26369985
13proline biosynthetic process (GO:0006561)4.24239922
14regulation of translational fidelity (GO:0006450)4.20008951
15DNA strand elongation (GO:0022616)4.15381895
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.09706240
17telomere maintenance via recombination (GO:0000722)4.03289212
18regulation of nucleobase-containing compound transport (GO:0032239)3.95044643
19DNA topological change (GO:0006265)3.91434227
20positive regulation of gamma-delta T cell activation (GO:0046645)3.89790639
21regulation of histone H3-K4 methylation (GO:0051569)3.77179692
22negative regulation of histone methylation (GO:0031061)3.71471598
23creatine metabolic process (GO:0006600)3.70184290
24intracellular estrogen receptor signaling pathway (GO:0030520)3.69298489
25mitotic recombination (GO:0006312)3.68393589
26nucleobase biosynthetic process (GO:0046112)3.63971963
27DNA replication initiation (GO:0006270)3.63834996
28glucose 6-phosphate metabolic process (GO:0051156)3.60469765
29telomere maintenance via telomere lengthening (GO:0010833)3.58351147
30mucosal-associated lymphoid tissue development (GO:0048537)3.56832957
31Peyers patch development (GO:0048541)3.56832957
32purine nucleobase biosynthetic process (GO:0009113)3.53227724
33nucleosome disassembly (GO:0006337)3.52178803
34protein-DNA complex disassembly (GO:0032986)3.52178803
35spliceosomal tri-snRNP complex assembly (GO:0000244)3.51136191
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.48426753
37mitotic chromosome condensation (GO:0007076)3.47493326
38histone H3 deacetylation (GO:0070932)3.46412227
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.43196894
40poly(A)+ mRNA export from nucleus (GO:0016973)3.41478112
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41203191
42nuclear pore organization (GO:0006999)3.39997577
43DNA unwinding involved in DNA replication (GO:0006268)3.39641198
44modulation by virus of host process (GO:0019054)3.37561169
45oxaloacetate metabolic process (GO:0006107)3.37333152
46regulation of early endosome to late endosome transport (GO:2000641)3.35854938
47histone H2A acetylation (GO:0043968)3.35273711
48stress granule assembly (GO:0034063)3.34008385
49protoporphyrinogen IX metabolic process (GO:0046501)3.33982645
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32587882
51mitotic sister chromatid segregation (GO:0000070)3.31186685
52regulation of histone methylation (GO:0031060)3.29485817
53erythrocyte maturation (GO:0043249)3.23669202
54regulation of chromatin binding (GO:0035561)3.22556462
55telomere organization (GO:0032200)3.21719746
56negative regulation of cell size (GO:0045792)3.21001485
57snRNA metabolic process (GO:0016073)3.19882670
58pore complex assembly (GO:0046931)3.19734769
59telomere maintenance (GO:0000723)3.19388276
60sister chromatid segregation (GO:0000819)3.18669425
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16336449
62regulation of ARF GTPase activity (GO:0032312)3.14599869
63cullin deneddylation (GO:0010388)3.09710367
64protein export from nucleus (GO:0006611)3.09267112
65mitotic nuclear envelope disassembly (GO:0007077)3.09077943
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08616857
67protein deneddylation (GO:0000338)3.08311044
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07356430
69histone H3-K4 methylation (GO:0051568)3.06184535
70formation of translation preinitiation complex (GO:0001731)3.06099801
71transcription-coupled nucleotide-excision repair (GO:0006283)3.06027682
72negative T cell selection (GO:0043383)3.05910102
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05669426
74mitochondrion transport along microtubule (GO:0047497)3.05669426
75histone H3-K9 demethylation (GO:0033169)3.04006458
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03189659
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02620785
78DNA replication checkpoint (GO:0000076)3.02248539
79viral mRNA export from host cell nucleus (GO:0046784)3.01636743
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.01495860
81erythrocyte development (GO:0048821)3.01486544
82negative thymic T cell selection (GO:0045060)3.01295390
83proline metabolic process (GO:0006560)3.00910151
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00786289
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99269874
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99269874
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.99135955
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.99135955
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.99135955
90positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98824565
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98529677
92negative regulation of ligase activity (GO:0051352)2.98529677
93response to epidermal growth factor (GO:0070849)2.96087525
94proteasome assembly (GO:0043248)2.96031197
95membrane disassembly (GO:0030397)2.95125913
96nuclear envelope disassembly (GO:0051081)2.95125913
973-UTR-mediated mRNA stabilization (GO:0070935)2.94851202
98translesion synthesis (GO:0019985)2.91078047
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.88232417
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87784623
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.87784623
102sequestering of actin monomers (GO:0042989)2.87501575
103postreplication repair (GO:0006301)2.87414919
104granulocyte differentiation (GO:0030851)2.87342216
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86838491
106response to vitamin A (GO:0033189)2.86346567
107RNA stabilization (GO:0043489)2.85799163
108mRNA stabilization (GO:0048255)2.85799163
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83068612
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83068612
111natural killer cell differentiation (GO:0001779)2.82582116
112positive regulation of histone deacetylation (GO:0031065)2.81918050
113tricarboxylic acid metabolic process (GO:0072350)2.81597320
1142-oxoglutarate metabolic process (GO:0006103)2.81434511
115gas transport (GO:0015669)2.80043645
116establishment of mitochondrion localization (GO:0051654)2.79754841
117positive regulation of B cell differentiation (GO:0045579)2.78003146
118regulation of NFAT protein import into nucleus (GO:0051532)2.77345022
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77165781
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.76750518
121CENP-A containing nucleosome assembly (GO:0034080)2.76360667
122histone H3-K4 trimethylation (GO:0080182)2.75384696
123maturation of SSU-rRNA (GO:0030490)2.74598455
124retinoic acid receptor signaling pathway (GO:0048384)2.73932372
125modulation by symbiont of host cellular process (GO:0044068)2.73743263
126histone deacetylation (GO:0016575)2.71331144
127regulation of B cell receptor signaling pathway (GO:0050855)2.71265672
128thymic T cell selection (GO:0045061)2.71210728
129regulation of gamma-delta T cell differentiation (GO:0045586)2.71013015
130antigen processing and presentation of endogenous antigen (GO:0019883)2.69842831
131tRNA methylation (GO:0030488)2.69540601
132mismatch repair (GO:0006298)2.69338586
133maternal placenta development (GO:0001893)2.67996704
134pentose-phosphate shunt (GO:0006098)2.67993703
135GMP metabolic process (GO:0046037)2.67745086
136positive regulation of gene expression, epigenetic (GO:0045815)2.67406188
137dosage compensation (GO:0007549)2.67217498
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.66848503
139termination of RNA polymerase III transcription (GO:0006386)2.66848503
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.66640933
141somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66640933
142regulation of gamma-delta T cell activation (GO:0046643)2.66604939
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66216777
144oxygen transport (GO:0015671)2.65575407
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65274824
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65274824
147negative regulation of fatty acid biosynthetic process (GO:0045717)2.64205838
148regulation of mitotic spindle organization (GO:0060236)2.62814237
149chromatin remodeling at centromere (GO:0031055)2.62490292
150spliceosomal snRNP assembly (GO:0000387)2.62334705
151negative regulation of mRNA metabolic process (GO:1903312)2.62250043
152histone methylation (GO:0016571)2.61746098
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.60572560
154negative regulation of mRNA processing (GO:0050686)2.60169596
155activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59971017
156G1/S transition of mitotic cell cycle (GO:0000082)2.59934952
157cell cycle G1/S phase transition (GO:0044843)2.59934952
158DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.59413319
159base-excision repair (GO:0006284)2.59154973
160regulation of erythrocyte differentiation (GO:0045646)2.59019755
161DNA replication-independent nucleosome organization (GO:0034724)2.58792948
162DNA replication-independent nucleosome assembly (GO:0006336)2.58792948
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.58457478
164negative regulation of phagocytosis (GO:0050765)2.58349372
165regulation of cellular amino acid metabolic process (GO:0006521)2.58101210
1667-methylguanosine mRNA capping (GO:0006370)2.57512258
167nuclear envelope organization (GO:0006998)2.57283815
168peptidyl-arginine omega-N-methylation (GO:0035247)2.57164160
169DNA-dependent DNA replication (GO:0006261)2.56859340
170maturation of 5.8S rRNA (GO:0000460)2.56314283
171vesicle coating (GO:0006901)2.55681146
172histone lysine demethylation (GO:0070076)2.55200858
173regulation of ARF protein signal transduction (GO:0032012)2.55183580
174DNA damage induced protein phosphorylation (GO:0006975)2.54934979
175spliceosomal complex assembly (GO:0000245)2.54547236
176positive regulation of nuclease activity (GO:0032075)2.54251156
177maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54132519
178positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.52977961
179Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52352733
180RNA capping (GO:0036260)2.51527832
1817-methylguanosine RNA capping (GO:0009452)2.51527832
182positive regulation of cell cycle arrest (GO:0071158)2.51366596
183pseudouridine synthesis (GO:0001522)2.49138531
184snRNA processing (GO:0016180)2.48318341
185IMP biosynthetic process (GO:0006188)2.47774645
186replication fork processing (GO:0031297)2.45963459
187antigen processing and presentation via MHC class Ib (GO:0002475)2.44952610
188somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44592686
189somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44592686
190isotype switching (GO:0045190)2.44592686
191positive regulation of ligase activity (GO:0051351)2.43815475
192DNA catabolic process, exonucleolytic (GO:0000738)2.43676183
193mRNA splicing, via spliceosome (GO:0000398)2.43234954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27625996
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.57922444
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42069477
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15550659
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13152867
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08765533
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.97681521
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96205288
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.92538081
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.90378439
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.85962993
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.67151364
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62776197
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.60024534
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58431328
16LXR_22292898_ChIP-Seq_THP-1_Human2.49401418
17VDR_23849224_ChIP-Seq_CD4+_Human2.48128958
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.47397999
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45269786
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42822036
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37679265
22CIITA_25753668_ChIP-Seq_RAJI_Human2.36729545
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.35128238
24FOXP3_21729870_ChIP-Seq_TREG_Human2.34961032
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.29376197
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29011591
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25898891
28* NCOR1_26117541_ChIP-Seq_K562_Human2.24054247
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23255323
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17162831
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.16577326
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14768918
33ELK3_25401928_ChIP-Seq_HUVEC_Human2.14441165
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12732080
35* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10133116
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.07083970
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.04559636
38HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03181187
39CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02101589
40KDM2B_26808549_Chip-Seq_DND41_Human2.01774658
41XRN2_22483619_ChIP-Seq_HELA_Human2.01751553
42TCF7_22412390_ChIP-Seq_EML_Mouse2.01413848
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95297195
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95121107
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.93285108
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93254813
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90375932
48* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90236458
49MYC_22102868_ChIP-Seq_BL_Human1.88860414
50* GABP_19822575_ChIP-Seq_HepG2_Human1.88707692
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.87738062
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86562155
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82143663
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80328688
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79490843
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.79427786
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78032649
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77194046
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76365300
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75802754
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74330675
62RACK7_27058665_Chip-Seq_MCF-7_Human1.73585255
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.73170860
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.73107638
65DCP1A_22483619_ChIP-Seq_HELA_Human1.72537601
66KDM2B_26808549_Chip-Seq_K562_Human1.70503952
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69589421
68* SPI1_23547873_ChIP-Seq_NB4_Human1.68655739
69P68_20966046_ChIP-Seq_HELA_Human1.67481965
70MAF_26560356_Chip-Seq_TH2_Human1.64739682
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.64721316
72GATA1_19941826_ChIP-Seq_K562_Human1.62695168
73ELK1_19687146_ChIP-ChIP_HELA_Human1.62515475
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61819601
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60387182
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.59701354
77SCL_19346495_ChIP-Seq_HPC-7_Human1.57265885
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56013715
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55185623
80* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52175394
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52164384
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51569703
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50375500
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49878281
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.49287108
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.49053545
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48255392
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48048911
89* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46134166
90* SPI1_23127762_ChIP-Seq_K562_Human1.45304031
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.44670787
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.42954300
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41835484
94TTF2_22483619_ChIP-Seq_HELA_Human1.41814602
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40794718
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38288872
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36823605
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.35743686
99STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35690696
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34760090
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.34416431
102CREB1_26743006_Chip-Seq_LNCaP_Human1.34307697
103VDR_21846776_ChIP-Seq_THP-1_Human1.34023939
104MYB_26560356_Chip-Seq_TH2_Human1.33743637
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32148515
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30029824
107SMC4_20622854_ChIP-Seq_HELA_Human1.29832978
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29368615
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27652518
110KDM5A_27292631_Chip-Seq_BREAST_Human1.26891838
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26363622
112TFEB_21752829_ChIP-Seq_HELA_Human1.25576652
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25437120
114ZNF263_19887448_ChIP-Seq_K562_Human1.25373656
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.24949622
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23526946
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23333670
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22976285
119VDR_24763502_ChIP-Seq_THP-1_Human1.22861363
120BCOR_27268052_Chip-Seq_Bcells_Human1.20338869
121MYB_26560356_Chip-Seq_TH1_Human1.19456789
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18935236
123ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17244228
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16264925
125BCL6_27268052_Chip-Seq_Bcells_Human1.15798081
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14162383
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.14121801
128MAF_26560356_Chip-Seq_TH1_Human1.13280132
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12670259
130AR_21909140_ChIP-Seq_LNCAP_Human1.12286903
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12096587
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09879644
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07896566
134UTX_26944678_Chip-Seq_JUKART_Human1.07795030
135PHF8_20622854_ChIP-Seq_HELA_Human1.07722346
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06027301
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05911937
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04632231
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04475400
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02666630
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02080052
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01985638
143MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01438485
144E2F1_20622854_ChIP-Seq_HELA_Human1.01233396
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01206628
146RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00982173
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00941557
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.00792645
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00790990
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00551905
151GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00441908
152PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00034954
153GATA2_19941826_ChIP-Seq_K562_Human0.99130927
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99098251
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98886664
156CTCF_26484167_Chip-Seq_Bcells_Mouse0.98243408
157GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97822086
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96689871
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96005776
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93398961
161KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93301988
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93200679
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91728200
164FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90588288
165PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85703110
166MYC_18940864_ChIP-ChIP_HL60_Human0.85317578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.96166042
2MP0003693_abnormal_embryo_hatching3.81898838
3MP0002396_abnormal_hematopoietic_system3.67122077
4MP0010094_abnormal_chromosome_stability3.65571254
5MP0000678_abnormal_parathyroid_gland3.39553364
6MP0003705_abnormal_hypodermis_morpholog3.28144703
7MP0005671_abnormal_response_to3.25779602
8MP0008058_abnormal_DNA_repair3.22421117
9MP0003763_abnormal_thymus_physiology3.14072961
10MP0001835_abnormal_antigen_presentation3.13982994
11MP0003111_abnormal_nucleus_morphology2.99321987
12MP0003077_abnormal_cell_cycle2.85290068
13MP0008007_abnormal_cellular_replicative2.69604914
14MP0005058_abnormal_lysosome_morphology2.68766237
15MP0004957_abnormal_blastocyst_morpholog2.67306419
16MP0005076_abnormal_cell_differentiation2.54733925
17MP0000685_abnormal_immune_system2.46481336
18MP0009785_altered_susceptibility_to2.44797278
19MP0002398_abnormal_bone_marrow2.42978428
20MP0008057_abnormal_DNA_replication2.36808675
21MP0001800_abnormal_humoral_immune2.26744044
22MP0009333_abnormal_splenocyte_physiolog2.24748568
23MP0004233_abnormal_muscle_weight2.12900567
24MP0002420_abnormal_adaptive_immunity2.12739976
25MP0001819_abnormal_immune_cell2.10096808
26MP0008260_abnormal_autophagy2.06055083
27MP0005075_abnormal_melanosome_morpholog2.05928341
28MP0002452_abnormal_antigen_presenting2.02237697
29MP0000716_abnormal_immune_system1.99479633
30MP0002249_abnormal_larynx_morphology1.98542174
31MP0000490_abnormal_crypts_of1.97363643
32MP0002723_abnormal_immune_serum1.96588107
33MP0000689_abnormal_spleen_morphology1.95145288
34MP0004808_abnormal_hematopoietic_stem1.94259534
35MP0002722_abnormal_immune_system1.90282768
36MP0002429_abnormal_blood_cell1.88824186
37MP0008995_early_reproductive_senescence1.87118522
38MP0005397_hematopoietic_system_phenotyp1.85479345
39MP0001545_abnormal_hematopoietic_system1.85479345
40MP0005025_abnormal_response_to1.82038590
41MP0000703_abnormal_thymus_morphology1.80679435
42MP0005000_abnormal_immune_tolerance1.77830461
43MP0009840_abnormal_foam_cell1.75433270
44MP0005387_immune_system_phenotype1.74554423
45MP0001790_abnormal_immune_system1.74554423
46MP0002148_abnormal_hypersensitivity_rea1.70619574
47MP0005174_abnormal_tail_pigmentation1.70172918
48MP0003866_abnormal_defecation1.66739501
49MP0003786_premature_aging1.66559927
50MP0004185_abnormal_adipocyte_glucose1.64537206
51MP0008877_abnormal_DNA_methylation1.62204926
52MP0005083_abnormal_biliary_tract1.61499563
53MP0000015_abnormal_ear_pigmentation1.59625133
54MP0004858_abnormal_nervous_system1.55728284
55MP0002132_abnormal_respiratory_system1.50962913
56MP0002166_altered_tumor_susceptibility1.49941243
57MP0002405_respiratory_system_inflammati1.49694718
58MP0004147_increased_porphyrin_level1.46775799
59MP0001986_abnormal_taste_sensitivity1.44332637
60MP0002019_abnormal_tumor_incidence1.42484090
61MP0002419_abnormal_innate_immunity1.40802910
62MP0003787_abnormal_imprinting1.40617088
63MP0001348_abnormal_lacrimal_gland1.38080420
64MP0003300_gastrointestinal_ulcer1.37806559
65MP0005409_darkened_coat_color1.37216517
66MP0003121_genomic_imprinting1.36332155
67MP0003123_paternal_imprinting1.35901901
68MP0005666_abnormal_adipose_tissue1.33924300
69MP0000313_abnormal_cell_death1.31992886
70MP0002095_abnormal_skin_pigmentation1.31153637
71MP0008932_abnormal_embryonic_tissue1.28884202
72MP0010155_abnormal_intestine_physiology1.27399832
73MP0003436_decreased_susceptibility_to1.25261416
74MP0004947_skin_inflammation1.24187998
75MP0005464_abnormal_platelet_physiology1.20839798
76MP0003724_increased_susceptibility_to1.19835610
77MP0001849_ear_inflammation1.18039943
78MP0001853_heart_inflammation1.16421108
79MP0001873_stomach_inflammation1.14376825
80MP0000609_abnormal_liver_physiology1.13792026
81MP0000350_abnormal_cell_proliferation1.11773625
82MP0000465_gastrointestinal_hemorrhage1.11576192
83MP0003172_abnormal_lysosome_physiology1.11208200
84MP0003984_embryonic_growth_retardation1.10566915
85MP0001672_abnormal_embryogenesis/_devel1.08744034
86MP0005380_embryogenesis_phenotype1.08744034
87MP0003943_abnormal_hepatobiliary_system1.08506153
88MP0001845_abnormal_inflammatory_respons1.08192645
89MP0002006_tumorigenesis1.07979258
90MP0005375_adipose_tissue_phenotype1.07043965
91MP0002970_abnormal_white_adipose1.05106398
92MP0001730_embryonic_growth_arrest1.04931555
93MP0000003_abnormal_adipose_tissue1.04559650
94MP0009672_abnormal_birth_weight1.03863406
95MP0002088_abnormal_embryonic_growth/wei1.02770298
96MP0002086_abnormal_extraembryonic_tissu1.02282450
97MP0009931_abnormal_skin_appearance1.01281935
98MP0003303_peritoneal_inflammation1.00530105
99MP0000858_altered_metastatic_potential0.98550933
100MP0004264_abnormal_extraembryonic_tissu0.97675167
101MP0010630_abnormal_cardiac_muscle0.97436386
102MP0009115_abnormal_fat_cell0.94193733
103MP0004859_abnormal_synaptic_plasticity0.94176499
104MP0002933_joint_inflammation0.93305082
105MP0005360_urolithiasis0.93210444
106MP0006035_abnormal_mitochondrial_morpho0.93099654
107MP0001188_hyperpigmentation0.92471051
108MP0002089_abnormal_postnatal_growth/wei0.91112709
109MP0006054_spinal_hemorrhage0.90785084
110MP0001915_intracranial_hemorrhage0.90446839
111MP0000681_abnormal_thyroid_gland0.90058752
112MP0005621_abnormal_cell_physiology0.87489309
113MP0003948_abnormal_gas_homeostasis0.86349625
114MP0006292_abnormal_olfactory_placode0.86291935
115MP0006082_CNS_inflammation0.85328638
116MP0002080_prenatal_lethality0.85154270
117MP0000598_abnormal_liver_morphology0.84350860
118MP0003656_abnormal_erythrocyte_physiolo0.82825128
119MP0001764_abnormal_homeostasis0.82476612
120MP0008469_abnormal_protein_level0.82000287
121MP0009697_abnormal_copulation0.81689301
122MP0010307_abnormal_tumor_latency0.79690889
123MP0003221_abnormal_cardiomyocyte_apopto0.79687924
124MP0005310_abnormal_salivary_gland0.79445579
125MP0003566_abnormal_cell_adhesion0.78793344
126MP0000747_muscle_weakness0.78287520
127MP0002210_abnormal_sex_determination0.77887605
128MP0003183_abnormal_peptide_metabolism0.77073488
129MP0002877_abnormal_melanocyte_morpholog0.76736412
130MP0001119_abnormal_female_reproductive0.75786123
131MP0003385_abnormal_body_wall0.74635005
132MP0003718_maternal_effect0.74304430
133MP0001727_abnormal_embryo_implantation0.72484059
134MP0009278_abnormal_bone_marrow0.72402904
135MP0000759_abnormal_skeletal_muscle0.72147956
136MP0004381_abnormal_hair_follicle0.71555686
137MP0000569_abnormal_digit_pigmentation0.71258599
138MP0003191_abnormal_cellular_cholesterol0.70083582
139MP0000372_irregular_coat_pigmentation0.68282729
140MP0002075_abnormal_coat/hair_pigmentati0.68039604
141MP0004782_abnormal_surfactant_physiolog0.67863905
142MP0000358_abnormal_cell_content/0.67714350
143MP0003315_abnormal_perineum_morphology0.66877802
144MP0000477_abnormal_intestine_morphology0.66218302
145MP0002160_abnormal_reproductive_system0.65556101
146MP0005384_cellular_phenotype0.65192400
147MP0001186_pigmentation_phenotype0.64368253
148MP0002102_abnormal_ear_morphology0.62550331
149MP0000371_diluted_coat_color0.61803327
150MP0001697_abnormal_embryo_size0.60499084

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.94050535
2Abnormal gallbladder physiology (HP:0012438)5.94050535
3Truncus arteriosus (HP:0001660)5.36238134
4Reticulocytosis (HP:0001923)5.05599866
5Hyperthyroidism (HP:0000836)4.90326072
6IgM deficiency (HP:0002850)4.38047092
7Seborrheic dermatitis (HP:0001051)4.13770605
8Bowel incontinence (HP:0002607)4.10345885
9Hypertensive crisis (HP:0100735)3.94719912
10Thrombocytosis (HP:0001894)3.92967576
11Atelectasis (HP:0100750)3.90266454
12Type I transferrin isoform profile (HP:0003642)3.82541297
13Abnormal large intestine physiology (HP:0012700)3.79821186
14Polycythemia (HP:0001901)3.72980503
15Reduced antithrombin III activity (HP:0001976)3.72861980
16Aplastic anemia (HP:0001915)3.72407200
17Abnormality of reticulocytes (HP:0004312)3.61465194
18Elevated erythrocyte sedimentation rate (HP:0003565)3.58851267
19Ankyloglossia (HP:0010296)3.57133750
20IgG deficiency (HP:0004315)3.37655337
21Peripheral hypomyelination (HP:0007182)3.30634270
22Cholelithiasis (HP:0001081)3.18082243
23Disproportionate tall stature (HP:0001519)3.15563481
24Birth length less than 3rd percentile (HP:0003561)3.10983244
25Hypoparathyroidism (HP:0000829)3.10347572
26Panhypogammaglobulinemia (HP:0003139)3.02698193
27Chronic obstructive pulmonary disease (HP:0006510)3.00044399
28Obstructive lung disease (HP:0006536)3.00044399
29Chromsome breakage (HP:0040012)2.97269142
30Type 2 muscle fiber atrophy (HP:0003554)2.96132502
31Recurrent bronchitis (HP:0002837)2.94908236
32Reticulocytopenia (HP:0001896)2.94502117
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.92131106
34Abnormal protein N-linked glycosylation (HP:0012347)2.92131106
35Abnormal protein glycosylation (HP:0012346)2.92131106
36Abnormal glycosylation (HP:0012345)2.92131106
37T lymphocytopenia (HP:0005403)2.91612383
38Severe combined immunodeficiency (HP:0004430)2.91489465
39Abnormality of DNA repair (HP:0003254)2.90775234
40Myositis (HP:0100614)2.88542771
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88160813
42Abnormality of T cell number (HP:0011839)2.87638034
43Abnormality of the tricuspid valve (HP:0001702)2.87049960
44Abnormality of T cells (HP:0002843)2.86012108
45Hyperacusis (HP:0010780)2.80759279
46Metaphyseal cupping (HP:0003021)2.80273290
47Abnormality of oral frenula (HP:0000190)2.78350995
48Recurrent viral infections (HP:0004429)2.76981985
49Abnormality of B cell number (HP:0010975)2.76379119
50B lymphocytopenia (HP:0010976)2.76379119
51Myelodysplasia (HP:0002863)2.73993529
52Obstructive sleep apnea (HP:0002870)2.70517851
53Oral leukoplakia (HP:0002745)2.69341480
54Muscle fiber atrophy (HP:0100295)2.64545947
55Deep palmar crease (HP:0006191)2.63381837
56Pointed chin (HP:0000307)2.61630416
57Combined immunodeficiency (HP:0005387)2.61429764
58Abnormal gallbladder morphology (HP:0012437)2.61328806
59Lymphoma (HP:0002665)2.60968232
60Amaurosis fugax (HP:0100576)2.59636995
61Meckel diverticulum (HP:0002245)2.59356279
62Lymphopenia (HP:0001888)2.57674709
63Abnormality of the preputium (HP:0100587)2.57657712
64Abnormality of the ileum (HP:0001549)2.57345066
65Bone marrow hypocellularity (HP:0005528)2.53675531
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.52613161
67Increased connective tissue (HP:0009025)2.52354918
68Colitis (HP:0002583)2.51837552
69Agammaglobulinemia (HP:0004432)2.49376796
70Chronic otitis media (HP:0000389)2.47626252
71Abnormality of T cell physiology (HP:0011840)2.46239928
72Distal upper limb amyotrophy (HP:0007149)2.45199260
73Upper limb amyotrophy (HP:0009129)2.45199260
74Abnormality of the gallbladder (HP:0005264)2.44880946
75Myopathic facies (HP:0002058)2.41114031
76Patellar dislocation (HP:0002999)2.40493825
77Broad face (HP:0000283)2.39951815
78Nonimmune hydrops fetalis (HP:0001790)2.38893270
79Hypoplasia of the thymus (HP:0000778)2.37719743
80Pancytopenia (HP:0001876)2.37101888
81Abnormal hair whorl (HP:0010721)2.35968223
82Recurrent fungal infections (HP:0002841)2.34706712
83Insomnia (HP:0100785)2.34562192
84Abnormality of chromosome stability (HP:0003220)2.34545348
85Dysmetric saccades (HP:0000641)2.34291102
86Eczematoid dermatitis (HP:0000976)2.32647633
87Hypoproteinemia (HP:0003075)2.32637488
88Thyroiditis (HP:0100646)2.30963289
89Petechiae (HP:0000967)2.30073918
90Ileus (HP:0002595)2.29464368
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.28864445
92Long palpebral fissure (HP:0000637)2.28525450
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.27835071
94Chronic diarrhea (HP:0002028)2.25238233
95Cortical dysplasia (HP:0002539)2.24194011
96Granulocytopenia (HP:0001913)2.21633808
97Gonadotropin excess (HP:0000837)2.21066549
98Centrally nucleated skeletal muscle fibers (HP:0003687)2.19692159
99Abnormality of the anterior horn cell (HP:0006802)2.17087486
100Degeneration of anterior horn cells (HP:0002398)2.17087486
101Abnormality of the fingertips (HP:0001211)2.15809918
102Patellar aplasia (HP:0006443)2.15621980
103Abnormal number of erythroid precursors (HP:0012131)2.14937095
104Distal lower limb amyotrophy (HP:0008944)2.14198780
105Stridor (HP:0010307)2.13941480
106Neutropenia (HP:0001875)2.13908663
107Hemorrhage of the eye (HP:0011885)2.13689744
108Pulmonary fibrosis (HP:0002206)2.12166342
109Hand muscle atrophy (HP:0009130)2.12121300
110Abnormality of eosinophils (HP:0001879)2.10665727
111Eosinophilia (HP:0001880)2.09829610
112Severe visual impairment (HP:0001141)2.09430918
113Gastrointestinal dysmotility (HP:0002579)2.08108778
114Deep venous thrombosis (HP:0002625)2.07775788
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07375845
116Cellular immunodeficiency (HP:0005374)2.07275792
117Duodenal stenosis (HP:0100867)2.05673349
118Small intestinal stenosis (HP:0012848)2.05673349
11911 pairs of ribs (HP:0000878)2.05122848
120Abnormality of homocysteine metabolism (HP:0010919)2.04543501
121Homocystinuria (HP:0002156)2.04543501
122Premature graying of hair (HP:0002216)2.03562287
123Microretrognathia (HP:0000308)2.03470216
124Gastrointestinal stroma tumor (HP:0100723)2.03158342
125Recurrent abscess formation (HP:0002722)2.02320424
126Microvesicular hepatic steatosis (HP:0001414)2.02134210
127Premature skin wrinkling (HP:0100678)2.01656174
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00184333
129Agnosia (HP:0010524)2.00092485
130Clubbing of toes (HP:0100760)2.00082375
131Obsessive-compulsive behavior (HP:0000722)1.99766830
132Meningitis (HP:0001287)1.99485391
133Poikiloderma (HP:0001029)1.99430092
134Abnormally folded helix (HP:0008544)1.98207452
135Biconcave vertebral bodies (HP:0004586)1.98070988
136Aplasia/Hypoplasia of the patella (HP:0006498)1.98014355
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.97855732
138Cerebral hypomyelination (HP:0006808)1.97492828
139Leukopenia (HP:0001882)1.96679043
140Heterotopia (HP:0002282)1.95714859
141Flat cornea (HP:0007720)1.93930029
142Attention deficit hyperactivity disorder (HP:0007018)1.93734230
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.93711191
144Segmental peripheral demyelination/remyelination (HP:0003481)1.93456953
145Increased IgE level (HP:0003212)1.92748730
146Pallor (HP:0000980)1.92402157
147IgA deficiency (HP:0002720)1.91767386
148Gastrointestinal inflammation (HP:0004386)1.91140716
149Cellulitis (HP:0100658)1.91113543
150Pendular nystagmus (HP:0012043)1.90410078
151Abnormality of cells of the erythroid lineage (HP:0012130)1.89184205
152Absent thumb (HP:0009777)1.88779944
153Overlapping toe (HP:0001845)1.88273208
154Optic nerve coloboma (HP:0000588)1.88132064
155Optic neuritis (HP:0100653)1.87739213
156Retrobulbar optic neuritis (HP:0100654)1.87739213
157Easy fatigability (HP:0003388)1.87045907
158Long eyelashes (HP:0000527)1.86968649
159Abnormality of the thoracic spine (HP:0100711)1.86441542
160Recurrent sinusitis (HP:0011108)1.85769833
161Vasculitis (HP:0002633)1.85031899
162Sparse lateral eyebrow (HP:0005338)1.82546758
163Venous abnormality (HP:0002624)1.82401730
164Recurrent cutaneous fungal infections (HP:0011370)1.82167156
165Chronic mucocutaneous candidiasis (HP:0002728)1.82167156
166Abnormality of cochlea (HP:0000375)1.81668952
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80616351
168Venous insufficiency (HP:0005293)1.80364284
169Leukocytosis (HP:0001974)1.78624534
170Broad palm (HP:0001169)1.76642201
171Thin bony cortex (HP:0002753)1.76133358
172Abnormality of the aortic arch (HP:0012303)1.75825388
173J-shaped sella turcica (HP:0002680)1.75285081
174Abnormality of the carotid arteries (HP:0005344)1.75142058
175Thin ribs (HP:0000883)1.74602010
176Cleft eyelid (HP:0000625)1.74492364
177Achilles tendon contracture (HP:0001771)1.74338713
178Sloping forehead (HP:0000340)1.73945874
179Decreased motor nerve conduction velocity (HP:0003431)1.73283719
180Macroorchidism (HP:0000053)1.71455733
181Hammertoe (HP:0001765)1.70731191
182Poikilocytosis (HP:0004447)1.69578937
183Cheekbone underdevelopment (HP:0010669)1.68629703
184Increased nuchal translucency (HP:0010880)1.67506614
185Sandal gap (HP:0001852)1.66932943
186Cerebral aneurysm (HP:0004944)1.66609305
187Abnormal hemoglobin (HP:0011902)1.66504919
188Ragged-red muscle fibers (HP:0003200)1.65572447
189Exercise-induced myalgia (HP:0003738)1.65085674
190Self-mutilation (HP:0000742)1.63784424
191Hyperbilirubinemia (HP:0002904)1.63513442
192Abnormality of the thymus (HP:0000777)1.63441126
193Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62601058
194Fatigue (HP:0012378)1.61909827
195Progressive external ophthalmoplegia (HP:0000590)1.61700529
196Abnormality of the Achilles tendon (HP:0005109)1.60935377
197Flat acetabular roof (HP:0003180)1.60711087
198Breech presentation (HP:0001623)1.58889920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.50743832
2BUB13.88633657
3ICK3.60258170
4RIPK43.55938030
5CDK123.02026511
6MAP4K13.00165543
7KSR22.78837084
8STK162.69774715
9TXK2.60044492
10TESK22.57328008
11SMG12.53563102
12ERN12.50817991
13EIF2AK12.46817341
14SIK12.28826768
15WEE12.28710403
16ACVR1B2.26440810
17FGFR42.22924287
18TLK12.19050195
19SIK22.17207719
20TGFBR12.04644884
21SRPK12.04427914
22BRD42.01389910
23KIT2.01141447
24EPHB11.94493069
25ZAP701.94261647
26BTK1.90761402
27BRSK21.87715806
28TSSK61.82889071
29FLT31.80081636
30IRAK41.75767218
31MAP3K121.72381678
32CCNB11.69216815
33KDR1.68348228
34PASK1.66354797
35JAK31.58201497
36BLK1.54550477
37TEC1.49374887
38CDC71.49232843
39MAP3K21.46766365
40NTRK31.46239911
41IRAK31.45005816
42MAP2K31.44092838
43SIK31.43394972
44TBK11.42777224
45MARK21.42097114
46AKT31.38496331
47IKBKE1.38308193
48PRPF4B1.37517849
49BRSK11.35933047
50CSF1R1.35381720
51NEK21.35264005
52ATR1.27842151
53CDK81.25537699
54TESK11.24607456
55RAF11.24303067
56MAP3K71.19692970
57EIF2AK31.19432121
58TYRO31.17781357
59MAP3K61.17319205
60MAP3K81.15787832
61NME21.15587901
62TYK21.14999841
63PTK61.14444354
64MTOR1.14432938
65BMPR1B1.13279474
66CDK71.12491288
67MKNK11.11266192
68MYLK1.09990418
69SYK1.08092401
70RPS6KA41.07597784
71MAP3K141.06931870
72DAPK11.05664914
73ZAK1.05194087
74KSR11.03777148
75RIPK11.03397056
76YES11.03161852
77RET1.00208478
78EPHA30.98568448
79LCK0.98425124
80CAMK1D0.98205229
81PAK40.97993661
82ITK0.97705684
83VRK10.97676327
84LYN0.95546396
85STK100.95354960
86MAP3K10.94718837
87MAP3K130.90884033
88CDC42BPA0.90843723
89PLK40.90624994
90PIM20.89992632
91NME10.89254181
92DYRK30.88638221
93PRKD20.85494234
94IKBKB0.82816291
95PLK10.82416426
96TAOK10.81045930
97AURKB0.80186267
98BMX0.79263430
99JAK20.77694609
100BCKDK0.74673020
101CASK0.74591287
102MAPK120.73461053
103PIM10.72857943
104WNK10.72577914
105EIF2AK20.72463795
106CLK10.71477481
107FGFR30.70864063
108TAOK20.70846656
109STK40.68877368
110MKNK20.64278518
111RPS6KA20.64126601
112PDPK10.61841193
113FES0.61628005
114CDK190.59721472
115MAP3K100.58945601
116CHUK0.58738366
117NLK0.58646568
118BRAF0.57945375
119TTN0.57918122
120TNK20.56216058
121MAP2K20.55765357
122GRK60.55125312
123CHEK20.53500666
124CDK20.52945782
125ALK0.51690429
126CDK40.51410598
127HCK0.50170412
128CHEK10.50075942
129RPS6KB20.49572067
130HIPK20.48965819
131MAPK110.47859722
132JAK10.47676488
133EEF2K0.46516267
134LRRK20.46256537
135CDK10.44902638
136MARK30.44844170
137RPS6KL10.44281814
138RPS6KC10.44281814
139PDGFRA0.43327130
140MAPK100.43016265
141PKN20.42479259
142PRKAA10.42098197
143CAMK1G0.41113960
144CSNK2A10.41058521
145PRKD30.40043997
146PDK10.39772037
147TGFBR20.39480642
148MAPK80.39146919
149PLK30.38602679
150MAPK30.38098437
151PAK10.38043760
152STK380.37698377
153TTK0.37687563
154RPS6KA60.37123935
155CAMKK10.37006162
156CSK0.36538929
157DAPK30.33580801
158MAP2K60.33035474
159CSNK2A20.32304181
160MAP3K110.31934900
161ERBB30.31775579
162GSK3B0.31424659
163TIE10.30985699
164AKT10.30747705
165TNIK0.30630436

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.68241753
2Mismatch repair_Homo sapiens_hsa034303.97338062
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.95827466
4Proteasome_Homo sapiens_hsa030503.52022041
5Base excision repair_Homo sapiens_hsa034103.40131040
6Spliceosome_Homo sapiens_hsa030402.86320693
7Homologous recombination_Homo sapiens_hsa034402.80334057
8Primary immunodeficiency_Homo sapiens_hsa053402.77747436
9Nucleotide excision repair_Homo sapiens_hsa034202.75998807
10RNA polymerase_Homo sapiens_hsa030202.71747259
11Ribosome_Homo sapiens_hsa030102.34298764
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30993355
13Pyrimidine metabolism_Homo sapiens_hsa002402.26584887
14VEGF signaling pathway_Homo sapiens_hsa043702.21795804
15Non-homologous end-joining_Homo sapiens_hsa034502.19843971
16Cell cycle_Homo sapiens_hsa041102.08813546
17Fanconi anemia pathway_Homo sapiens_hsa034602.08338122
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06603067
19RNA transport_Homo sapiens_hsa030131.98156359
20One carbon pool by folate_Homo sapiens_hsa006701.93279469
21mTOR signaling pathway_Homo sapiens_hsa041501.80781998
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80779271
23Pancreatic cancer_Homo sapiens_hsa052121.79414793
24Antigen processing and presentation_Homo sapiens_hsa046121.64875509
25Endometrial cancer_Homo sapiens_hsa052131.62085179
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.60631461
27Measles_Homo sapiens_hsa051621.55013589
28ErbB signaling pathway_Homo sapiens_hsa040121.54782022
29Renal cell carcinoma_Homo sapiens_hsa052111.51560348
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.47290977
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.42732321
32RNA degradation_Homo sapiens_hsa030181.40936156
33Basal transcription factors_Homo sapiens_hsa030221.40744274
34Lysine degradation_Homo sapiens_hsa003101.40632992
35Herpes simplex infection_Homo sapiens_hsa051681.39746708
36Insulin signaling pathway_Homo sapiens_hsa049101.39307677
37Purine metabolism_Homo sapiens_hsa002301.35978190
38Epstein-Barr virus infection_Homo sapiens_hsa051691.35965442
39Choline metabolism in cancer_Homo sapiens_hsa052311.33912283
40Glioma_Homo sapiens_hsa052141.32008037
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28897625
42Prolactin signaling pathway_Homo sapiens_hsa049171.27790742
43Prion diseases_Homo sapiens_hsa050201.26824532
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.25711553
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24451625
46p53 signaling pathway_Homo sapiens_hsa041151.23988097
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23859605
48Bladder cancer_Homo sapiens_hsa052191.23660801
49Protein export_Homo sapiens_hsa030601.22282010
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18298882
51mRNA surveillance pathway_Homo sapiens_hsa030151.17180238
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12518767
53Allograft rejection_Homo sapiens_hsa053301.12385281
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11459691
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11417307
56Hematopoietic cell lineage_Homo sapiens_hsa046401.06841858
57GnRH signaling pathway_Homo sapiens_hsa049121.06693978
58N-Glycan biosynthesis_Homo sapiens_hsa005101.05296865
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98236488
60HIF-1 signaling pathway_Homo sapiens_hsa040660.98185738
61Inositol phosphate metabolism_Homo sapiens_hsa005620.97829215
62AMPK signaling pathway_Homo sapiens_hsa041520.96484079
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.93905058
64B cell receptor signaling pathway_Homo sapiens_hsa046620.92276496
65Type II diabetes mellitus_Homo sapiens_hsa049300.92126000
66T cell receptor signaling pathway_Homo sapiens_hsa046600.92104946
67Viral carcinogenesis_Homo sapiens_hsa052030.88790897
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88204440
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87732098
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87526858
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86302076
72Other glycan degradation_Homo sapiens_hsa005110.83683401
73Legionellosis_Homo sapiens_hsa051340.83551121
74Prostate cancer_Homo sapiens_hsa052150.83350107
75Shigellosis_Homo sapiens_hsa051310.82434579
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.82336298
77Estrogen signaling pathway_Homo sapiens_hsa049150.81061537
78Leishmaniasis_Homo sapiens_hsa051400.80674437
79Pentose phosphate pathway_Homo sapiens_hsa000300.80574554
80Long-term potentiation_Homo sapiens_hsa047200.79721409
81Systemic lupus erythematosus_Homo sapiens_hsa053220.78660628
82Insulin resistance_Homo sapiens_hsa049310.76747294
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76385688
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76185809
85Regulation of autophagy_Homo sapiens_hsa041400.75809697
86Apoptosis_Homo sapiens_hsa042100.72184259
87HTLV-I infection_Homo sapiens_hsa051660.72053501
88Autoimmune thyroid disease_Homo sapiens_hsa053200.70819473
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70137917
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.69883729
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.69357043
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69224965
93MicroRNAs in cancer_Homo sapiens_hsa052060.67017442
94Influenza A_Homo sapiens_hsa051640.66992388
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66899707
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64562699
97* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63106713
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62987493
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.62134465
100Graft-versus-host disease_Homo sapiens_hsa053320.61725053
101Folate biosynthesis_Homo sapiens_hsa007900.60410227
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.60035116
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59411551
104Hepatitis B_Homo sapiens_hsa051610.58411620
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57466324
106Selenocompound metabolism_Homo sapiens_hsa004500.57378766
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56975804
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55609317
109Acute myeloid leukemia_Homo sapiens_hsa052210.51544121
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.51403305
111FoxO signaling pathway_Homo sapiens_hsa040680.51197072
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49972022
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.48674402
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48076779
115Viral myocarditis_Homo sapiens_hsa054160.47342752
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45611079
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44096291
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.43646865
119Arginine biosynthesis_Homo sapiens_hsa002200.41868442
120TNF signaling pathway_Homo sapiens_hsa046680.41798370
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41028355
122Tuberculosis_Homo sapiens_hsa051520.40870120
123Endocytosis_Homo sapiens_hsa041440.40591922
124ABC transporters_Homo sapiens_hsa020100.39014486
125Galactose metabolism_Homo sapiens_hsa000520.38501026
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38185372
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37437275
128MAPK signaling pathway_Homo sapiens_hsa040100.37229037
129Thyroid cancer_Homo sapiens_hsa052160.37073490
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37071009
131Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37069674
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36989492
133Fructose and mannose metabolism_Homo sapiens_hsa000510.36687539
134Notch signaling pathway_Homo sapiens_hsa043300.35476846
135Small cell lung cancer_Homo sapiens_hsa052220.34654968
136Osteoclast differentiation_Homo sapiens_hsa043800.32795483
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.32624936
138Toxoplasmosis_Homo sapiens_hsa051450.31509892
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30304654
140Hepatitis C_Homo sapiens_hsa051600.30014426
141Colorectal cancer_Homo sapiens_hsa052100.29229360
142Sulfur relay system_Homo sapiens_hsa041220.26985348
143Chronic myeloid leukemia_Homo sapiens_hsa052200.25121990
144Chemokine signaling pathway_Homo sapiens_hsa040620.23988416
145Biosynthesis of amino acids_Homo sapiens_hsa012300.23249293
146Carbon metabolism_Homo sapiens_hsa012000.21574071
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20830845
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20791170
149Non-small cell lung cancer_Homo sapiens_hsa052230.20292757
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19607930
151Phagosome_Homo sapiens_hsa041450.18090845
152Type I diabetes mellitus_Homo sapiens_hsa049400.16962621

Most similar genes based on co-expression Upload to Enrichr

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