PPIL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.27238218
2polyketide metabolic process (GO:0030638)7.27238218
3doxorubicin metabolic process (GO:0044598)7.27238218
4ribosomal small subunit biogenesis (GO:0042274)5.27033074
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99925261
6ribosomal small subunit assembly (GO:0000028)4.94601052
7cullin deneddylation (GO:0010388)4.72708917
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.57354178
9aminoglycoside antibiotic metabolic process (GO:0030647)4.50171142
10ATP synthesis coupled proton transport (GO:0015986)4.49118962
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49118962
12protein deneddylation (GO:0000338)4.39669015
13rRNA modification (GO:0000154)4.38362100
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.34573718
15pseudouridine synthesis (GO:0001522)4.23608802
16rRNA methylation (GO:0031167)4.18832113
17DNA double-strand break processing (GO:0000729)4.16186949
18viral transcription (GO:0019083)4.03609922
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02540593
20maturation of SSU-rRNA (GO:0030490)3.99803331
21ribonucleoprotein complex biogenesis (GO:0022613)3.99157135
22DNA replication checkpoint (GO:0000076)3.92941573
23translational termination (GO:0006415)3.92373841
24protein neddylation (GO:0045116)3.86658391
25DNA deamination (GO:0045006)3.81436698
26DNA damage response, detection of DNA damage (GO:0042769)3.77758431
27DNA replication initiation (GO:0006270)3.74922686
28ribosome biogenesis (GO:0042254)3.71885130
29protein localization to kinetochore (GO:0034501)3.71848244
30SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68454976
31respiratory chain complex IV assembly (GO:0008535)3.64833587
32cotranslational protein targeting to membrane (GO:0006613)3.62847857
33formation of translation preinitiation complex (GO:0001731)3.59731067
34protein targeting to ER (GO:0045047)3.58625124
35regulation of mammary gland epithelial cell proliferation (GO:0033599)3.55563131
36telomere maintenance via semi-conservative replication (GO:0032201)3.53381068
37respiratory electron transport chain (GO:0022904)3.52912626
38proteasome assembly (GO:0043248)3.51799016
39ribosomal large subunit biogenesis (GO:0042273)3.51795711
40cellular component biogenesis (GO:0044085)3.51170436
41electron transport chain (GO:0022900)3.50129558
42centriole replication (GO:0007099)3.49457846
43rRNA transcription (GO:0009303)3.45916210
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.40699882
45protein localization to endoplasmic reticulum (GO:0070972)3.38041177
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36477746
47translational elongation (GO:0006414)3.36014131
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.31559335
49termination of RNA polymerase III transcription (GO:0006386)3.31559335
50negative regulation of telomere maintenance (GO:0032205)3.31147699
51DNA strand elongation involved in DNA replication (GO:0006271)3.30533335
52cytochrome complex assembly (GO:0017004)3.30454314
53negative regulation of telomerase activity (GO:0051974)3.29827412
54water-soluble vitamin biosynthetic process (GO:0042364)3.28759686
55quinone metabolic process (GO:1901661)3.28672742
56translation (GO:0006412)3.27079404
57platelet dense granule organization (GO:0060155)3.26986892
58replication fork processing (GO:0031297)3.26399088
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26001352
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.26001352
61NADH dehydrogenase complex assembly (GO:0010257)3.26001352
62negative regulation of cell cycle G2/M phase transition (GO:1902750)3.23633787
63negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.22575245
64negative regulation of epidermis development (GO:0045683)3.20532286
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19919739
66establishment of integrated proviral latency (GO:0075713)3.18319061
67DNA strand elongation (GO:0022616)3.17085423
68rRNA processing (GO:0006364)3.16593895
69interferon-gamma production (GO:0032609)3.15291811
70transcription from RNA polymerase I promoter (GO:0006360)3.13624927
71positive regulation of DNA-dependent DNA replication (GO:2000105)3.13335763
72histone exchange (GO:0043486)3.12897306
73viral life cycle (GO:0019058)3.09527986
74telomere maintenance via recombination (GO:0000722)3.08340816
75regulation of mitotic spindle checkpoint (GO:1903504)3.08150906
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.08150906
77DNA replication-dependent nucleosome organization (GO:0034723)3.07398155
78DNA replication-dependent nucleosome assembly (GO:0006335)3.07398155
79maintenance of protein location in nucleus (GO:0051457)3.06964249
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06940429
81rRNA metabolic process (GO:0016072)3.05346656
82GDP-mannose metabolic process (GO:0019673)3.05178279
83kinetochore organization (GO:0051383)3.03088983
84mitotic recombination (GO:0006312)3.01052413
85translational initiation (GO:0006413)3.00061784
86cellular protein complex disassembly (GO:0043624)2.99082297
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98994847
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97797580
89chaperone-mediated protein transport (GO:0072321)2.97719580
90regulation of double-strand break repair via homologous recombination (GO:0010569)2.96932810
91negative regulation of epidermal cell differentiation (GO:0045605)2.96655830
92protein-cofactor linkage (GO:0018065)2.96553665
93kinetochore assembly (GO:0051382)2.96544813
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96349076
95CENP-A containing nucleosome assembly (GO:0034080)2.94271089
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92054085
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92054085
98protein complex biogenesis (GO:0070271)2.91502605
99behavioral response to nicotine (GO:0035095)2.91451459
1007-methylguanosine mRNA capping (GO:0006370)2.91023836
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90997725
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90997725
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90997725
104regulation of telomere maintenance via telomerase (GO:0032210)2.90448396
105somite rostral/caudal axis specification (GO:0032525)2.89882647
106RNA capping (GO:0036260)2.89779344
1077-methylguanosine RNA capping (GO:0009452)2.89779344
108protein localization to chromosome, centromeric region (GO:0071459)2.89605930
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88812452
110response to pheromone (GO:0019236)2.88486962
111mitotic sister chromatid segregation (GO:0000070)2.86295903
112recombinational repair (GO:0000725)2.85178767
113chromatin remodeling at centromere (GO:0031055)2.83863073
114double-strand break repair via homologous recombination (GO:0000724)2.81662091
115inner mitochondrial membrane organization (GO:0007007)2.80270014
116termination of RNA polymerase I transcription (GO:0006363)2.80184079
117organelle disassembly (GO:1903008)2.79733185
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78776827
119signal transduction involved in DNA damage checkpoint (GO:0072422)2.78776827
120DNA catabolic process, exonucleolytic (GO:0000738)2.78544021
121regulation of cilium movement (GO:0003352)2.77600588
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77502454
123regulation of MHC class I biosynthetic process (GO:0045343)2.76968566
124spliceosomal complex assembly (GO:0000245)2.76853601
125protein K6-linked ubiquitination (GO:0085020)2.76228375
126telomere maintenance via telomere lengthening (GO:0010833)2.75972286
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.75885417
128tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74313074
129RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74313074
130regulation of translation in response to stress (GO:0043555)2.73471555
131meiotic chromosome segregation (GO:0045132)2.72110026
132RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72024015
133mitochondrial respiratory chain complex assembly (GO:0033108)2.69733871
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.69663666
135maturation of 5.8S rRNA (GO:0000460)2.69595485
136regulation of mitochondrial translation (GO:0070129)2.68637493
137histone mRNA metabolic process (GO:0008334)2.67942934
138positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66638812
139regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.66537707
140DNA replication-independent nucleosome organization (GO:0034724)2.66215724
141DNA replication-independent nucleosome assembly (GO:0006336)2.66215724
142maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66147775
143piRNA metabolic process (GO:0034587)2.65457679
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63922740
145regulation of meiosis I (GO:0060631)2.60372512
146epithelial cilium movement (GO:0003351)2.60033230
147intracellular protein transmembrane import (GO:0044743)2.58804483
148synapsis (GO:0007129)2.58396253
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.57976822
150neural tube formation (GO:0001841)2.57416023
151nonmotile primary cilium assembly (GO:0035058)2.57351366
152tRNA processing (GO:0008033)2.56408801
153hydrogen ion transmembrane transport (GO:1902600)2.55903991
154intraciliary transport (GO:0042073)2.54104716
155ATP biosynthetic process (GO:0006754)2.53583046
156reciprocal DNA recombination (GO:0035825)2.52596335
157reciprocal meiotic recombination (GO:0007131)2.52596335
158GPI anchor metabolic process (GO:0006505)2.52311991
159DNA ligation (GO:0006266)2.52197774
160purine nucleoside triphosphate biosynthetic process (GO:0009145)2.50288691
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49600697
162mannosylation (GO:0097502)2.49381964
163preassembly of GPI anchor in ER membrane (GO:0016254)2.48864621
164peptidyl-histidine modification (GO:0018202)2.48664848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.20537665
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.59737870
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.56836136
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10050118
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.04631796
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.43270914
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.33752995
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25910068
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.19939194
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.19939194
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.19939194
12ZNF274_21170338_ChIP-Seq_K562_Hela3.19623408
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12578163
14VDR_22108803_ChIP-Seq_LS180_Human3.01396412
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76221838
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75908634
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74114461
18* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73617572
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72719404
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.62935732
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57918673
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55134174
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53216954
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.48410074
25IGF1R_20145208_ChIP-Seq_DFB_Human2.46935844
26FUS_26573619_Chip-Seq_HEK293_Human2.41721411
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39744607
28* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39730061
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34893742
30EWS_26573619_Chip-Seq_HEK293_Human2.33478912
31VDR_23849224_ChIP-Seq_CD4+_Human2.31286346
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23583528
33FOXP3_21729870_ChIP-Seq_TREG_Human2.19506762
34IRF1_19129219_ChIP-ChIP_H3396_Human2.16366654
35NOTCH1_21737748_ChIP-Seq_TLL_Human2.09395227
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.07375999
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05804336
38ELK1_19687146_ChIP-ChIP_HELA_Human2.01779865
39SALL1_21062744_ChIP-ChIP_HESCs_Human2.00340495
40ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00306523
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.96899109
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95678660
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95231831
44TAF15_26573619_Chip-Seq_HEK293_Human1.94293783
45XRN2_22483619_ChIP-Seq_HELA_Human1.85187364
46P300_19829295_ChIP-Seq_ESCs_Human1.80027198
47DCP1A_22483619_ChIP-Seq_HELA_Human1.78537246
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77524367
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75631852
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75014806
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73181193
52* TTF2_22483619_ChIP-Seq_HELA_Human1.72855383
53GBX2_23144817_ChIP-Seq_PC3_Human1.72670086
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70730452
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69457522
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67713309
57* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66843640
58* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66756702
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64348419
60* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64212385
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63474716
62* GABP_19822575_ChIP-Seq_HepG2_Human1.60449445
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59414432
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56528733
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52700323
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52475536
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52093098
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50701606
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48127996
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.44256598
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44211641
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43574910
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40391671
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39532284
75ER_23166858_ChIP-Seq_MCF-7_Human1.38819196
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38548418
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37400242
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36738246
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35238502
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34918463
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32528201
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32329814
83TP53_22573176_ChIP-Seq_HFKS_Human1.32298455
84* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31783587
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31600831
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30764242
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30260249
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29747748
89* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29172898
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28398327
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25212916
92* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24705755
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.22983086
94MYC_18940864_ChIP-ChIP_HL60_Human1.22541243
95* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22374522
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.21901242
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21901242
98EZH2_22144423_ChIP-Seq_EOC_Human1.21322704
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20558188
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20361442
101* NANOG_19829295_ChIP-Seq_ESCs_Human1.19509471
102* SOX2_19829295_ChIP-Seq_ESCs_Human1.19509471
103CBP_20019798_ChIP-Seq_JUKART_Human1.16394563
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16394563
105* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16283516
106SPI1_23547873_ChIP-Seq_NB4_Human1.16231408
107* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16155350
108BCAT_22108803_ChIP-Seq_LS180_Human1.15453811
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14733823
110* NFE2_27457419_Chip-Seq_LIVER_Mouse1.11054070
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10714566
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10262819
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09530038
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08183379
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06571435
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05525406
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04529627
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03902461
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03825917
120SCL_19346495_ChIP-Seq_HPC-7_Human1.03548519
121CIITA_25753668_ChIP-Seq_RAJI_Human1.02152851
122AR_25329375_ChIP-Seq_VCAP_Human1.01239383
123RNF2_27304074_Chip-Seq_NSC_Mouse1.00890422
124* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00580355
125* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99624797
126* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99150284
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98797386
128E2F1_21310950_ChIP-Seq_MCF-7_Human0.98469909
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98254680
130SMAD4_21799915_ChIP-Seq_A2780_Human0.97710425
131TCF4_22108803_ChIP-Seq_LS180_Human0.97198403
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96998321
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96668638
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.96597300
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.96159173
136AR_20517297_ChIP-Seq_VCAP_Human0.96075054
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95087861
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94915704
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94705513
140* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94625853
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.94411416
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94383007
143NCOR_22424771_ChIP-Seq_293T_Human0.93002008
144HTT_18923047_ChIP-ChIP_STHdh_Human0.92969434
145* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92708310
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89700392
147BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89187951
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88868752
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88313953
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.83137521
151KDM5A_27292631_Chip-Seq_BREAST_Human0.83033341
152* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74679750
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.73796210
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.73415200
155RBPJ_22232070_ChIP-Seq_NCS_Mouse0.72347494
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71955152
157AR_21909140_ChIP-Seq_LNCAP_Human0.71407569
158OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71245272

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.87373206
2MP0008057_abnormal_DNA_replication3.76163158
3MP0005075_abnormal_melanosome_morpholog3.57520796
4MP0004957_abnormal_blastocyst_morpholog3.17949534
5MP0008877_abnormal_DNA_methylation2.91487888
6MP0003011_delayed_dark_adaptation2.88510765
7MP0010094_abnormal_chromosome_stability2.74123369
8MP0003693_abnormal_embryo_hatching2.62590405
9MP0003195_calcinosis2.50800101
10MP0008058_abnormal_DNA_repair2.47825513
11MP0003077_abnormal_cell_cycle2.37864062
12MP0005394_taste/olfaction_phenotype2.27745967
13MP0005499_abnormal_olfactory_system2.27745967
14MP0006072_abnormal_retinal_apoptosis2.25562629
15MP0003136_yellow_coat_color2.15811496
16MP0008007_abnormal_cellular_replicative2.14702152
17MP0002396_abnormal_hematopoietic_system2.09905436
18MP0009379_abnormal_foot_pigmentation2.09706797
19MP0002277_abnormal_respiratory_mucosa2.04687815
20MP0002837_dystrophic_cardiac_calcinosis2.03822056
21MP0003111_abnormal_nucleus_morphology1.94167018
22MP0005551_abnormal_eye_electrophysiolog1.89480555
23MP0006035_abnormal_mitochondrial_morpho1.88406349
24MP0003890_abnormal_embryonic-extraembry1.88277173
25MP0008932_abnormal_embryonic_tissue1.84710449
26MP0004147_increased_porphyrin_level1.82675953
27MP0003880_abnormal_central_pattern1.82569521
28MP0005084_abnormal_gallbladder_morpholo1.79815472
29MP0000490_abnormal_crypts_of1.78265612
30MP0003122_maternal_imprinting1.76060496
31MP0002132_abnormal_respiratory_system1.74782204
32MP0003121_genomic_imprinting1.72642477
33MP0004264_abnormal_extraembryonic_tissu1.72159219
34MP0001986_abnormal_taste_sensitivity1.71566557
35MP0009697_abnormal_copulation1.70629713
36MP0004381_abnormal_hair_follicle1.66328955
37MP0005253_abnormal_eye_physiology1.60429827
38MP0003786_premature_aging1.56433019
39MP0008995_early_reproductive_senescence1.54414239
40MP0008789_abnormal_olfactory_epithelium1.51164398
41MP0003938_abnormal_ear_development1.50748329
42MP0002938_white_spotting1.49575412
43MP0000372_irregular_coat_pigmentation1.47657397
44MP0002234_abnormal_pharynx_morphology1.46913248
45MP0002736_abnormal_nociception_after1.46628180
46MP0001188_hyperpigmentation1.43324992
47MP0003186_abnormal_redox_activity1.42900709
48MP0003567_abnormal_fetal_cardiomyocyte1.42531394
49MP0000631_abnormal_neuroendocrine_gland1.42351897
50MP0000049_abnormal_middle_ear1.41216694
51MP0001835_abnormal_antigen_presentation1.39915719
52MP0009333_abnormal_splenocyte_physiolog1.38519857
53MP0001293_anophthalmia1.36638766
54MP0005671_abnormal_response_to1.35146687
55MP0002653_abnormal_ependyma_morphology1.32804534
56MP0000350_abnormal_cell_proliferation1.32180965
57MP0001968_abnormal_touch/_nociception1.32103104
58MP0006276_abnormal_autonomic_nervous1.31469612
59MP0005646_abnormal_pituitary_gland1.30421633
60MP0003315_abnormal_perineum_morphology1.29508729
61MP0005645_abnormal_hypothalamus_physiol1.27981763
62MP0001984_abnormal_olfaction1.27007814
63MP0002254_reproductive_system_inflammat1.25883235
64MP0003787_abnormal_imprinting1.24832338
65MP0003937_abnormal_limbs/digits/tail_de1.24275825
66MP0000678_abnormal_parathyroid_gland1.24122341
67MP0008875_abnormal_xenobiotic_pharmacok1.23860250
68MP0009785_altered_susceptibility_to1.23107428
69MP0005174_abnormal_tail_pigmentation1.21984799
70MP0003123_paternal_imprinting1.20521460
71MP0008872_abnormal_physiological_respon1.20351418
72MP0003283_abnormal_digestive_organ1.18561109
73MP0003763_abnormal_thymus_physiology1.16335384
74MP0002735_abnormal_chemical_nociception1.16223893
75MP0002751_abnormal_autonomic_nervous1.16059182
76MP0002332_abnormal_exercise_endurance1.15536947
77MP0001485_abnormal_pinna_reflex1.15531544
78MP0001905_abnormal_dopamine_level1.14954776
79MP0000313_abnormal_cell_death1.13820000
80MP0003806_abnormal_nucleotide_metabolis1.13305626
81MP0005257_abnormal_intraocular_pressure1.12387744
82MP0001929_abnormal_gametogenesis1.12201675
83MP0002272_abnormal_nervous_system1.11982734
84MP0000569_abnormal_digit_pigmentation1.11412852
85MP0009046_muscle_twitch1.10833093
86MP0004145_abnormal_muscle_electrophysio1.10607249
87MP0004808_abnormal_hematopoietic_stem1.10129434
88MP0000689_abnormal_spleen_morphology1.06682629
89MP0004142_abnormal_muscle_tone1.05855160
90MP0002876_abnormal_thyroid_physiology1.04917570
91MP0002398_abnormal_bone_marrow1.04107383
92MP0000653_abnormal_sex_gland1.03900359
93MP0004133_heterotaxia1.03870682
94MP0002127_abnormal_cardiovascular_syste1.03233647
95MP0002095_abnormal_skin_pigmentation1.03106661
96MP0001919_abnormal_reproductive_system1.02879660
97MP0002102_abnormal_ear_morphology1.02166168
98MP0002722_abnormal_immune_system1.02147475
99MP0001286_abnormal_eye_development1.01351287
100MP0001145_abnormal_male_reproductive1.01304906
101MP0006036_abnormal_mitochondrial_physio1.00376528
102MP0002928_abnormal_bile_duct0.99791491
103MP0001672_abnormal_embryogenesis/_devel0.99524930
104MP0005380_embryogenesis_phenotype0.99524930
105MP0001764_abnormal_homeostasis0.98534787
106MP0000015_abnormal_ear_pigmentation0.97938132
107MP0009745_abnormal_behavioral_response0.97731286
108MP0005423_abnormal_somatic_nervous0.97609176
109MP0005195_abnormal_posterior_eye0.97381430
110MP0003119_abnormal_digestive_system0.97158677
111MP0003646_muscle_fatigue0.94764277
112MP0003698_abnormal_male_reproductive0.93724383
113MP0002148_abnormal_hypersensitivity_rea0.93593343
114MP0000858_altered_metastatic_potential0.93103825
115MP0001529_abnormal_vocalization0.91949900
116MP0002019_abnormal_tumor_incidence0.91577975
117MP0001324_abnormal_eye_pigmentation0.90995659
118MP0001486_abnormal_startle_reflex0.89653343
119MP0004885_abnormal_endolymph0.89372982
120MP0004742_abnormal_vestibular_system0.89296554
121MP0001800_abnormal_humoral_immune0.88890842
122MP0002429_abnormal_blood_cell0.88522658
123MP0002163_abnormal_gland_morphology0.87321059
124MP0005391_vision/eye_phenotype0.86887387
125MP0006082_CNS_inflammation0.85630115
126MP0002557_abnormal_social/conspecific_i0.85560433
127MP0000566_synostosis0.84496985
128MP0001119_abnormal_female_reproductive0.84477971
129MP0002420_abnormal_adaptive_immunity0.84475297
130MP0000716_abnormal_immune_system0.84132307
131MP0001853_heart_inflammation0.84116870
132MP0005000_abnormal_immune_tolerance0.83338644
133MP0010030_abnormal_orbit_morphology0.83316028
134MP0001819_abnormal_immune_cell0.83227420
135MP0005025_abnormal_response_to0.82668796
136MP0002822_catalepsy0.81987295
137MP0000703_abnormal_thymus_morphology0.81451577
138MP0000685_abnormal_immune_system0.81343178
139MP0004215_abnormal_myocardial_fiber0.80865164
140MP0002088_abnormal_embryonic_growth/wei0.80792934
141MP0005409_darkened_coat_color0.80788805
142MP0002114_abnormal_axial_skeleton0.80713100
143MP0003984_embryonic_growth_retardation0.80334897
144MP0002932_abnormal_joint_morphology0.79621995
145MP0002160_abnormal_reproductive_system0.77550676
146MP0002233_abnormal_nose_morphology0.77381947
147MP0003718_maternal_effect0.76632237
148MP0005266_abnormal_metabolism0.76238008
149MP0005389_reproductive_system_phenotype0.74213027
150MP0002452_abnormal_antigen_presenting0.73314596
151MP0002723_abnormal_immune_serum0.72979475
152MP0000762_abnormal_tongue_morphology0.72805344
153MP0000343_altered_response_to0.71303992
154MP0002210_abnormal_sex_determination0.71080277
155MP0002092_abnormal_eye_morphology0.70519207
156MP0002638_abnormal_pupillary_reflex0.69256683
157MP0000358_abnormal_cell_content/0.69008988

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.35413435
23-Methylglutaconic aciduria (HP:0003535)4.22356093
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22201464
4Microvesicular hepatic steatosis (HP:0001414)4.06117376
5Chromsome breakage (HP:0040012)3.92528783
6Pancreatic cysts (HP:0001737)3.85108220
7Aplastic anemia (HP:0001915)3.84124569
8Reduced antithrombin III activity (HP:0001976)3.81237661
9Type I transferrin isoform profile (HP:0003642)3.72939701
10Abnormality of cells of the erythroid lineage (HP:0012130)3.68453668
11Abnormal number of erythroid precursors (HP:0012131)3.56172974
12Pancreatic fibrosis (HP:0100732)3.54857708
13Abnormality of midbrain morphology (HP:0002418)3.52697099
14Molar tooth sign on MRI (HP:0002419)3.52697099
15True hermaphroditism (HP:0010459)3.46968793
16Reticulocytopenia (HP:0001896)3.23256188
17Nephroblastoma (Wilms tumor) (HP:0002667)3.21526157
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12531089
19Nephronophthisis (HP:0000090)3.06291591
20Embryonal renal neoplasm (HP:0011794)3.04088481
21Abnormal lung lobation (HP:0002101)3.03041157
22Meckel diverticulum (HP:0002245)2.99053698
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97953565
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.93983757
25Rib fusion (HP:0000902)2.90835940
26Medial flaring of the eyebrow (HP:0010747)2.90219984
27Abnormality of the ileum (HP:0001549)2.82576446
28Multiple enchondromatosis (HP:0005701)2.80211997
29Hepatic necrosis (HP:0002605)2.79811148
30Hypochromic microcytic anemia (HP:0004840)2.79534947
31Rectovaginal fistula (HP:0000143)2.75095442
32Rectal fistula (HP:0100590)2.75095442
33Supernumerary spleens (HP:0009799)2.74126652
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.69710454
35Hypoplasia of the fovea (HP:0007750)2.69619267
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.69619267
37Acute necrotizing encephalopathy (HP:0006965)2.65558447
38Pallor (HP:0000980)2.64882217
39Abnormality of the renal cortex (HP:0011035)2.63826119
40Birth length less than 3rd percentile (HP:0003561)2.63334850
41Colon cancer (HP:0003003)2.59736147
42Abnormality of the preputium (HP:0100587)2.58585291
43Partial duplication of thumb phalanx (HP:0009944)2.53813306
44Abnormality of the renal medulla (HP:0100957)2.51849244
45Congenital, generalized hypertrichosis (HP:0004540)2.47272308
46Anomalous pulmonary venous return (HP:0010772)2.46984279
47Microretrognathia (HP:0000308)2.44531238
48Mitochondrial inheritance (HP:0001427)2.43959382
49Congenital stationary night blindness (HP:0007642)2.43647464
50Methylmalonic acidemia (HP:0002912)2.40065164
51Increased CSF lactate (HP:0002490)2.37990404
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37592440
53Abnormal protein N-linked glycosylation (HP:0012347)2.37592440
54Abnormal protein glycosylation (HP:0012346)2.37592440
55Abnormal glycosylation (HP:0012345)2.37592440
56Renal cortical cysts (HP:0000803)2.37238730
57Renal Fanconi syndrome (HP:0001994)2.36669072
58Cerebral edema (HP:0002181)2.35662194
59Congenital primary aphakia (HP:0007707)2.35210369
60Gait imbalance (HP:0002141)2.35151503
61Elevated erythrocyte sedimentation rate (HP:0003565)2.34745476
62Duodenal stenosis (HP:0100867)2.32350987
63Small intestinal stenosis (HP:0012848)2.32350987
64Testicular atrophy (HP:0000029)2.30706627
65Optic disc pallor (HP:0000543)2.29131641
66Bone marrow hypocellularity (HP:0005528)2.28388304
67Abnormality of chromosome stability (HP:0003220)2.28376401
68Myelodysplasia (HP:0002863)2.27620387
69Triphalangeal thumb (HP:0001199)2.27145289
70Intestinal fistula (HP:0100819)2.27059631
71Sclerocornea (HP:0000647)2.26441936
72Macrocytic anemia (HP:0001972)2.26173514
73Duplication of thumb phalanx (HP:0009942)2.25819004
74Rhabdomyosarcoma (HP:0002859)2.25463978
75Increased serum lactate (HP:0002151)2.25191438
76Hepatocellular necrosis (HP:0001404)2.24006551
77Increased hepatocellular lipid droplets (HP:0006565)2.23021440
78Abnormality of the labia minora (HP:0012880)2.21595967
79Chronic hepatic failure (HP:0100626)2.21240723
80Nephrogenic diabetes insipidus (HP:0009806)2.19999536
81Abnormality of glycolysis (HP:0004366)2.19483417
82Increased serum pyruvate (HP:0003542)2.19483417
83Nasolacrimal duct obstruction (HP:0000579)2.18792175
84Abnormality of alanine metabolism (HP:0010916)2.16718995
85Hyperalaninemia (HP:0003348)2.16718995
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16718995
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.16329592
88Abnormal mitochondria in muscle tissue (HP:0008316)2.15452236
89Anencephaly (HP:0002323)2.14506423
90Partial duplication of the phalanx of hand (HP:0009999)2.13651851
91Cystic liver disease (HP:0006706)2.12746016
92Abnormality of the pulmonary veins (HP:0011718)2.12428054
93Vaginal fistula (HP:0004320)2.12129261
94Trismus (HP:0000211)2.11362218
95Intestinal atresia (HP:0011100)2.11326741
96Hyperglycinemia (HP:0002154)2.09286760
97Aplasia/Hypoplasia of the tongue (HP:0010295)2.08808919
98Abnormality of the pons (HP:0007361)2.08741755
99Lactic acidosis (HP:0003128)2.08533425
100Type II lissencephaly (HP:0007260)2.07440161
101Genital tract atresia (HP:0001827)2.07158610
102Hypoplasia of the pons (HP:0012110)2.06675478
103Progressive external ophthalmoplegia (HP:0000590)2.06075021
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03732374
105Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03732374
106Septo-optic dysplasia (HP:0100842)2.02611451
107Male pseudohermaphroditism (HP:0000037)2.01505429
108Abnormality of the fovea (HP:0000493)2.01252546
109Vaginal atresia (HP:0000148)2.00810560
110Progressive macrocephaly (HP:0004481)2.00667402
111Pendular nystagmus (HP:0012043)2.00295757
112Abnormality of the phalanges of the hallux (HP:0010057)1.99893201
113Ragged-red muscle fibers (HP:0003200)1.99636676
114Bifid tongue (HP:0010297)1.99379330
115Bile duct proliferation (HP:0001408)1.98375631
116Abnormal biliary tract physiology (HP:0012439)1.98375631
117Abolished electroretinogram (ERG) (HP:0000550)1.97461967
118Facial cleft (HP:0002006)1.97067019
119Poor head control (HP:0002421)1.96995107
120Pancytopenia (HP:0001876)1.96234333
121Glossoptosis (HP:0000162)1.95756475
122Hypothermia (HP:0002045)1.94903160
123Cleft eyelid (HP:0000625)1.94673979
124Sparse eyelashes (HP:0000653)1.94372362
125Impulsivity (HP:0100710)1.93806036
126Sloping forehead (HP:0000340)1.91864772
127Methylmalonic aciduria (HP:0012120)1.91580697
128Exercise intolerance (HP:0003546)1.91253269
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.91194205
130Rough bone trabeculation (HP:0100670)1.90572311
131Respiratory failure (HP:0002878)1.89216304
132Exertional dyspnea (HP:0002875)1.88622015
133Postaxial foot polydactyly (HP:0001830)1.88392751
134Volvulus (HP:0002580)1.88192626
135Congenital hepatic fibrosis (HP:0002612)1.87464464
136Abnormality of the duodenum (HP:0002246)1.86994531
137Postaxial hand polydactyly (HP:0001162)1.86524824
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85623923
139Tubular atrophy (HP:0000092)1.82358041
140Short tibia (HP:0005736)1.82111015
141Muscle fiber atrophy (HP:0100295)1.81767689
142Median cleft lip (HP:0000161)1.81630240
143Hyperglycinuria (HP:0003108)1.81359120
144Lethargy (HP:0001254)1.81210895
145Neoplasm of striated muscle (HP:0009728)1.81023425
146Ependymoma (HP:0002888)1.80809913
147Abnormality of serum amino acid levels (HP:0003112)1.80514879
148Type 2 muscle fiber atrophy (HP:0003554)1.80467777
149Acute encephalopathy (HP:0006846)1.80209260
150Optic nerve hypoplasia (HP:0000609)1.79022866
151Hypochromic anemia (HP:0001931)1.79012700
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78781129
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.78649080
154Asplenia (HP:0001746)1.78247032
155Abnormality of renal resorption (HP:0011038)1.77774605
156Increased intramyocellular lipid droplets (HP:0012240)1.77105853
157Anophthalmia (HP:0000528)1.76680647
158Combined immunodeficiency (HP:0005387)1.76482041
159Absent thumb (HP:0009777)1.76386859
160Short middle phalanx of the 5th finger (HP:0004220)1.76344886
161Attenuation of retinal blood vessels (HP:0007843)1.75447463
162Increased IgM level (HP:0003496)1.73950803
163Medulloblastoma (HP:0002885)1.71438492
164Lipid accumulation in hepatocytes (HP:0006561)1.70969693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.72766517
2ADRBK23.62624037
3GRK53.44692159
4NME22.96113055
5FRK2.88279927
6MAP4K22.71428144
7STK162.68711930
8GRK62.56047033
9VRK22.51748829
10NUAK12.50741467
11GRK72.49020533
12WNK32.49020242
13SRPK12.29929365
14GRK12.21805260
15WEE12.21520022
16VRK12.16726728
17CSF1R1.93241722
18EIF2AK21.91819370
19CDK81.91817990
20EIF2AK31.89992779
21EIF2AK11.89541354
22TRIM281.87355312
23MKNK11.83583684
24PNCK1.78425111
25BUB11.78373016
26ACVR1B1.78090890
27TTK1.75395265
28MKNK21.71343620
29MST41.67527626
30CDK71.65088221
31NEK11.64131626
32TGFBR21.54988193
33TNIK1.54845071
34MATK1.50748421
35CDC71.48000324
36CASK1.45025922
37PIM21.42008867
38MOS1.37056616
39WNK41.35673541
40MAPK131.35042568
41INSRR1.33097247
42ZAK1.33032425
43BCR1.32238164
44PLK11.28976597
45STK101.26735587
46PINK11.24395331
47NME11.21748639
48TEC1.19099032
49YES11.17176862
50PLK41.14004948
51CHEK21.13813518
52PLK21.10386948
53MAP3K41.09133251
54MAPK71.08685857
55STK391.08219399
56IRAK41.06415851
57MAP2K71.05720556
58ERBB31.05194750
59BCKDK1.04246933
60TAOK31.02815352
61ADRBK10.99986990
62KIT0.99983020
63TLK10.99786070
64BRSK20.99418181
65OXSR10.99100091
66TAF10.98418684
67TXK0.98252473
68DYRK30.98001510
69ERN10.94339141
70AURKA0.89897614
71CCNB10.89846627
72CDK190.88459425
73RPS6KB20.88458025
74STK38L0.88185605
75MAP2K60.87727572
76EPHA20.87701630
77IKBKB0.85745664
78STK30.82191759
79PRKG20.81675507
80CSNK1G10.77784842
81AURKB0.76893882
82PRKCE0.74572020
83PRKCG0.74432728
84IRAK30.74137700
85DYRK20.73945795
86AKT30.73511260
87TSSK60.73248348
88ATR0.72266179
89PDK20.72148406
90CSNK1G30.71228907
91CSNK1G20.70248620
92EPHA40.69953346
93CDK30.64366223
94CSNK1A1L0.62631561
95MAPK150.62480206
96CHEK10.61730811
97PBK0.61699695
98BRSK10.60626334
99TGFBR10.56491457
100CAMK40.55733952
101SIK30.55438810
102MUSK0.55246301
103FLT30.55114179
104CSNK2A10.55000321
105TIE10.52965192
106HIPK20.52017044
107BMPR1B0.49190631
108PAK30.48405419
109DAPK20.47976420
110CLK10.47425886
111PLK30.47326059
112BTK0.46728923
113SYK0.46584262
114CSNK2A20.46013749
115PAK40.45460506
116MAPKAPK50.44701418
117PIM10.44643271
118PRKCI0.43673538
119ATM0.43415182
120BRAF0.42802350
121MAP3K140.42791932
122MAP3K120.42425572
123KDR0.41913715
124PASK0.41782386
125PKN10.41602586
126LYN0.41539137
127NLK0.41198806
128BLK0.40623060
129RPS6KA50.40212423
130MINK10.39380522
131PAK10.39219744
132TESK20.38624970
133FGFR20.38296656
134STK40.37688941
135PRKCD0.36426968
136NEK20.35939139
137PRKACA0.35076957
138MAP2K40.34843464
139LCK0.34580848
140RPS6KA40.33847664
141CDK20.33431864
142CDK40.32931082
143PRKCQ0.32035723
144OBSCN0.31394677
145CAMKK20.30437677
146MAPK40.29347567
147CSNK1E0.29139880
148ARAF0.27811658

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.77214466
2DNA replication_Homo sapiens_hsa030303.72785645
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64265573
4RNA polymerase_Homo sapiens_hsa030203.41964034
5Proteasome_Homo sapiens_hsa030503.33076488
6Mismatch repair_Homo sapiens_hsa034303.09307846
7Homologous recombination_Homo sapiens_hsa034402.89348934
8Spliceosome_Homo sapiens_hsa030402.40603765
9Fanconi anemia pathway_Homo sapiens_hsa034602.38064754
10Non-homologous end-joining_Homo sapiens_hsa034502.38056836
11Nucleotide excision repair_Homo sapiens_hsa034202.37307840
12Pyrimidine metabolism_Homo sapiens_hsa002402.34999539
13Base excision repair_Homo sapiens_hsa034102.23696338
14Basal transcription factors_Homo sapiens_hsa030222.15594381
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12329440
16Oxidative phosphorylation_Homo sapiens_hsa001902.07051152
17RNA transport_Homo sapiens_hsa030132.01390504
18Protein export_Homo sapiens_hsa030601.91722117
19Parkinsons disease_Homo sapiens_hsa050121.90781299
20Propanoate metabolism_Homo sapiens_hsa006401.86651269
21Vitamin B6 metabolism_Homo sapiens_hsa007501.78962249
22Phototransduction_Homo sapiens_hsa047441.76618410
23RNA degradation_Homo sapiens_hsa030181.76332599
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66192629
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64728874
26Huntingtons disease_Homo sapiens_hsa050161.59905783
27Cell cycle_Homo sapiens_hsa041101.56152511
28Butanoate metabolism_Homo sapiens_hsa006501.54451587
29Arachidonic acid metabolism_Homo sapiens_hsa005901.51577933
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50343215
31Selenocompound metabolism_Homo sapiens_hsa004501.48340141
32One carbon pool by folate_Homo sapiens_hsa006701.38480373
33Caffeine metabolism_Homo sapiens_hsa002321.37356849
34Nitrogen metabolism_Homo sapiens_hsa009101.35224713
35Purine metabolism_Homo sapiens_hsa002301.33322928
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.29161566
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27964684
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26037963
39Alzheimers disease_Homo sapiens_hsa050101.21617626
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18317719
41Fructose and mannose metabolism_Homo sapiens_hsa000511.11263684
42Primary immunodeficiency_Homo sapiens_hsa053401.09089087
43Tryptophan metabolism_Homo sapiens_hsa003801.06569740
44mRNA surveillance pathway_Homo sapiens_hsa030151.04912448
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04369274
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00609656
47p53 signaling pathway_Homo sapiens_hsa041151.00573359
48Peroxisome_Homo sapiens_hsa041460.99448452
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.98759026
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97904722
51Herpes simplex infection_Homo sapiens_hsa051680.93049305
52Nicotine addiction_Homo sapiens_hsa050330.90313260
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89791285
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89177397
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.88319091
56Steroid biosynthesis_Homo sapiens_hsa001000.86489349
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84988082
58Linoleic acid metabolism_Homo sapiens_hsa005910.83436869
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82188389
60Galactose metabolism_Homo sapiens_hsa000520.81038291
61Pyruvate metabolism_Homo sapiens_hsa006200.80176682
62Thyroid cancer_Homo sapiens_hsa052160.79769154
63Other glycan degradation_Homo sapiens_hsa005110.78700633
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.77699755
65Fatty acid elongation_Homo sapiens_hsa000620.74309493
66Taste transduction_Homo sapiens_hsa047420.74245115
67Retinol metabolism_Homo sapiens_hsa008300.74030930
68Olfactory transduction_Homo sapiens_hsa047400.73252603
69Collecting duct acid secretion_Homo sapiens_hsa049660.72507792
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71706791
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.71228537
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69106487
73Epstein-Barr virus infection_Homo sapiens_hsa051690.68980377
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67605078
75Folate biosynthesis_Homo sapiens_hsa007900.67220515
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66756109
77Hematopoietic cell lineage_Homo sapiens_hsa046400.62557206
78Antigen processing and presentation_Homo sapiens_hsa046120.61375977
79Ether lipid metabolism_Homo sapiens_hsa005650.61173189
80Systemic lupus erythematosus_Homo sapiens_hsa053220.60743158
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.58440751
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58100157
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57768773
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56454602
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56090358
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55998373
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54248549
88beta-Alanine metabolism_Homo sapiens_hsa004100.53680749
89Allograft rejection_Homo sapiens_hsa053300.52722031
90Sulfur metabolism_Homo sapiens_hsa009200.52242232
91Oocyte meiosis_Homo sapiens_hsa041140.51995761
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50758688
93Metabolic pathways_Homo sapiens_hsa011000.49782710
94Vitamin digestion and absorption_Homo sapiens_hsa049770.49233064
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47440243
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46619190
97Hedgehog signaling pathway_Homo sapiens_hsa043400.43995398
98Measles_Homo sapiens_hsa051620.41404209
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40814633
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40679324
101Autoimmune thyroid disease_Homo sapiens_hsa053200.39771235
102Fatty acid degradation_Homo sapiens_hsa000710.38849548
103Glutathione metabolism_Homo sapiens_hsa004800.38554264
104Morphine addiction_Homo sapiens_hsa050320.38260054
105Sulfur relay system_Homo sapiens_hsa041220.37958822
106Fat digestion and absorption_Homo sapiens_hsa049750.37552869
107GABAergic synapse_Homo sapiens_hsa047270.37246197
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36367162
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35274373
110African trypanosomiasis_Homo sapiens_hsa051430.35081338
111Pentose phosphate pathway_Homo sapiens_hsa000300.34346250
112Asthma_Homo sapiens_hsa053100.33766094
113Graft-versus-host disease_Homo sapiens_hsa053320.33760397
114N-Glycan biosynthesis_Homo sapiens_hsa005100.32826185
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32292641
116Apoptosis_Homo sapiens_hsa042100.31340444
117Cardiac muscle contraction_Homo sapiens_hsa042600.31205242
118Legionellosis_Homo sapiens_hsa051340.31033107
119TGF-beta signaling pathway_Homo sapiens_hsa043500.30153489
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28435401
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.28384124
122Fatty acid metabolism_Homo sapiens_hsa012120.27869077
123Histidine metabolism_Homo sapiens_hsa003400.27778593
124Malaria_Homo sapiens_hsa051440.27395455
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26928329
126Viral carcinogenesis_Homo sapiens_hsa052030.26361426
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25711009
128Leishmaniasis_Homo sapiens_hsa051400.24989457
129HTLV-I infection_Homo sapiens_hsa051660.24440197
130Regulation of autophagy_Homo sapiens_hsa041400.24420054
131Pathways in cancer_Homo sapiens_hsa052000.22799147
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22518522
133Alcoholism_Homo sapiens_hsa050340.21955827
134Pertussis_Homo sapiens_hsa051330.19851579
135Influenza A_Homo sapiens_hsa051640.18867623
136Rheumatoid arthritis_Homo sapiens_hsa053230.18789935
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.18306138
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17528605
139Chemical carcinogenesis_Homo sapiens_hsa052040.17461157
140Shigellosis_Homo sapiens_hsa051310.14725489
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.12641139
142Serotonergic synapse_Homo sapiens_hsa047260.12446920
143Basal cell carcinoma_Homo sapiens_hsa052170.11658856

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