PPIL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.36563180
2CENP-A containing nucleosome assembly (GO:0034080)4.36351905
3kinetochore organization (GO:0051383)4.30359029
4chromatin remodeling at centromere (GO:0031055)4.22292045
5kinetochore assembly (GO:0051382)4.12837926
6nuclear pore complex assembly (GO:0051292)3.94008813
7negative regulation of DNA-dependent DNA replication (GO:2000104)3.87592322
8metaphase plate congression (GO:0051310)3.85991104
9nuclear pore organization (GO:0006999)3.76467386
10DNA replication-independent nucleosome organization (GO:0034724)3.71440445
11DNA replication-independent nucleosome assembly (GO:0006336)3.71440445
12DNA double-strand break processing (GO:0000729)3.65179656
13DNA replication checkpoint (GO:0000076)3.62653305
14microtubule depolymerization (GO:0007019)3.60223084
15RNA capping (GO:0036260)3.55333381
167-methylguanosine RNA capping (GO:0009452)3.55333381
177-methylguanosine mRNA capping (GO:0006370)3.54744745
18histone exchange (GO:0043486)3.50986917
19meiotic chromosome segregation (GO:0045132)3.49661585
20transcription elongation from RNA polymerase I promoter (GO:0006362)3.49169200
21protein localization to kinetochore (GO:0034501)3.47256102
22DNA replication initiation (GO:0006270)3.44165432
23cullin deneddylation (GO:0010388)3.44112405
24termination of RNA polymerase I transcription (GO:0006363)3.42304749
25establishment of chromosome localization (GO:0051303)3.41135236
26organelle disassembly (GO:1903008)3.40491508
27termination of RNA polymerase III transcription (GO:0006386)3.39306830
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.39306830
29regulation of centriole replication (GO:0046599)3.37818089
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.33975385
31regulation of meiosis I (GO:0060631)3.31565508
32pore complex assembly (GO:0046931)3.27013627
33monoubiquitinated protein deubiquitination (GO:0035520)3.25557946
34telomere maintenance via recombination (GO:0000722)3.25321901
35negative regulation of DNA recombination (GO:0045910)3.20090040
36telomere maintenance via semi-conservative replication (GO:0032201)3.19966051
37postreplication repair (GO:0006301)3.19935996
38synapsis (GO:0007129)3.19067727
39protein K6-linked ubiquitination (GO:0085020)3.16917160
40mitotic recombination (GO:0006312)3.15935736
41transcription-coupled nucleotide-excision repair (GO:0006283)3.15893841
42transcription from RNA polymerase I promoter (GO:0006360)3.15676903
43ribonucleoprotein complex disassembly (GO:0032988)3.13164991
44respiratory chain complex IV assembly (GO:0008535)3.10537803
45protein neddylation (GO:0045116)3.10343725
46maturation of 5.8S rRNA (GO:0000460)3.09767719
47establishment of integrated proviral latency (GO:0075713)3.07824589
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07213077
49intraciliary transport (GO:0042073)3.04855172
50prenylation (GO:0097354)3.03748720
51protein prenylation (GO:0018342)3.03748720
52DNA ligation (GO:0006266)3.03195635
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03002717
54regulation of mitotic spindle checkpoint (GO:1903504)3.03002717
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02840131
56replication fork processing (GO:0031297)3.02805538
57ribosome biogenesis (GO:0042254)3.02511174
58ribosomal small subunit assembly (GO:0000028)3.02058614
59histone H2A acetylation (GO:0043968)3.01955642
60DNA catabolic process, exonucleolytic (GO:0000738)3.01490225
61lactate metabolic process (GO:0006089)3.00597861
62DNA damage response, detection of DNA damage (GO:0042769)2.97282616
63DNA-templated transcription, elongation (GO:0006354)2.96816373
64protein deneddylation (GO:0000338)2.96574447
65establishment of protein localization to mitochondrial membrane (GO:0090151)2.94759860
66transcription initiation from RNA polymerase I promoter (GO:0006361)2.94635571
67transcription elongation from RNA polymerase II promoter (GO:0006368)2.93897725
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90972026
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.90972026
70NADH dehydrogenase complex assembly (GO:0010257)2.90972026
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.90910857
72DNA strand elongation involved in DNA replication (GO:0006271)2.89369124
73protein complex biogenesis (GO:0070271)2.88358144
74mitotic spindle checkpoint (GO:0071174)2.87835082
75intra-S DNA damage checkpoint (GO:0031573)2.87442821
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87353183
77nucleotide-excision repair, DNA gap filling (GO:0006297)2.86243542
78mitotic sister chromatid cohesion (GO:0007064)2.86165877
79regulation of spindle organization (GO:0090224)2.85756248
80single strand break repair (GO:0000012)2.85513475
81cilium morphogenesis (GO:0060271)2.84973141
82DNA replication-dependent nucleosome assembly (GO:0006335)2.84372610
83DNA replication-dependent nucleosome organization (GO:0034723)2.84372610
84DNA-templated transcription, termination (GO:0006353)2.82854763
85histone H2B ubiquitination (GO:0033523)2.82761809
86attachment of spindle microtubules to kinetochore (GO:0008608)2.82627458
87mitochondrial respiratory chain complex assembly (GO:0033108)2.82426654
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82181398
89recombinational repair (GO:0000725)2.81035692
90double-strand break repair via homologous recombination (GO:0000724)2.79661545
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79614138
92DNA synthesis involved in DNA repair (GO:0000731)2.79520233
93ATP-dependent chromatin remodeling (GO:0043044)2.78812652
94histone mRNA metabolic process (GO:0008334)2.78442332
95telomere maintenance via telomere lengthening (GO:0010833)2.77323868
96DNA strand elongation (GO:0022616)2.77267044
97platelet dense granule organization (GO:0060155)2.76895829
98regulation of DNA endoreduplication (GO:0032875)2.76664528
99regulation of transcription from RNA polymerase I promoter (GO:0006356)2.76415936
100spindle checkpoint (GO:0031577)2.75799714
101ribosome assembly (GO:0042255)2.75520121
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74561989
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72820583
104regulation of helicase activity (GO:0051095)2.72289229
105non-recombinational repair (GO:0000726)2.72044923
106double-strand break repair via nonhomologous end joining (GO:0006303)2.72044923
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.69899727
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69686829
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69686829
110nucleotide-excision repair (GO:0006289)2.69492535
111centriole assembly (GO:0098534)2.69377008
112regulation of double-strand break repair via homologous recombination (GO:0010569)2.69034691
113maturation of SSU-rRNA (GO:0030490)2.68552291
114resolution of meiotic recombination intermediates (GO:0000712)2.68393815
115proteasome assembly (GO:0043248)2.67724314
116sister chromatid cohesion (GO:0007062)2.67406103
117microtubule anchoring (GO:0034453)2.66597348
118epithelial cilium movement (GO:0003351)2.66308740
119ribonucleoprotein complex biogenesis (GO:0022613)2.65694780
120mismatch repair (GO:0006298)2.64904762
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64454307
122rRNA processing (GO:0006364)2.62203230
123water-soluble vitamin biosynthetic process (GO:0042364)2.62034469
124RNA-dependent DNA replication (GO:0006278)2.61688166
125establishment of viral latency (GO:0019043)2.61211254
126mitotic sister chromatid segregation (GO:0000070)2.61029804
127transcription from RNA polymerase III promoter (GO:0006383)2.60233565
128telomere maintenance (GO:0000723)2.59914249
129chromosome segregation (GO:0007059)2.59807171
130telomere organization (GO:0032200)2.59598642
131response to X-ray (GO:0010165)2.59553008
132regulation of mitotic sister chromatid separation (GO:0010965)2.59151462
133regulation of mitotic sister chromatid segregation (GO:0033047)2.59151462
134regulation of sister chromatid segregation (GO:0033045)2.59151462
135exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58596290
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58124193
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58124193
138purine nucleobase biosynthetic process (GO:0009113)2.57935754
139spliceosomal snRNP assembly (GO:0000387)2.57297792
140positive regulation of histone H3-K4 methylation (GO:0051571)2.56715666
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56507832
142DNA topological change (GO:0006265)2.56099377
143response to pheromone (GO:0019236)2.55544084
144negative regulation of fibroblast apoptotic process (GO:2000270)2.55247827
145rRNA metabolic process (GO:0016072)2.54315069
146mitotic nuclear envelope disassembly (GO:0007077)2.54304623
147positive regulation of viral transcription (GO:0050434)2.54080890
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.53661337
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.53661337
150isotype switching (GO:0045190)2.53661337
151negative regulation of chromosome segregation (GO:0051985)2.53038358
152cytochrome complex assembly (GO:0017004)2.52494108
153telomere maintenance via telomerase (GO:0007004)2.52351944
154mitotic spindle assembly checkpoint (GO:0007094)2.50856629
155neural tube formation (GO:0001841)2.50539989
156centriole replication (GO:0007099)2.50442181
157mitotic G2/M transition checkpoint (GO:0044818)2.49982132
158regulation of cilium movement (GO:0003352)2.49905454
159spindle assembly checkpoint (GO:0071173)2.49605751
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.49301449
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49301449
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49301449
163negative regulation of sister chromatid segregation (GO:0033046)2.49301449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.95560652
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50677412
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43240546
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39870337
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.04119841
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.85983872
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.83599611
8VDR_22108803_ChIP-Seq_LS180_Human2.75835104
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.69554144
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65132295
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61273445
12ZNF274_21170338_ChIP-Seq_K562_Hela2.57836199
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49127483
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.45874113
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41513216
16* VDR_23849224_ChIP-Seq_CD4+_Human2.35350991
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34861406
18ELK1_19687146_ChIP-ChIP_HELA_Human2.28280346
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26101630
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24340699
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.24247673
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24217509
23TAF15_26573619_Chip-Seq_HEK293_Human2.21777581
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19434428
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16757238
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14188714
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09613331
28* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.07814492
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.06396932
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01440786
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99876121
32GBX2_23144817_ChIP-Seq_PC3_Human1.99775512
33P300_19829295_ChIP-Seq_ESCs_Human1.95997569
34FOXP3_21729870_ChIP-Seq_TREG_Human1.93914853
35* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93229722
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.91590508
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86547950
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86468393
39* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84477374
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.84349576
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82880973
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82803947
43FUS_26573619_Chip-Seq_HEK293_Human1.78878575
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.77321678
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73952368
46EWS_26573619_Chip-Seq_HEK293_Human1.71268058
47* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69897199
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68416191
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63881635
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61732096
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60859418
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60169334
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59787384
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58422262
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57983964
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57136996
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.56956871
58DCP1A_22483619_ChIP-Seq_HELA_Human1.56273849
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.52287027
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50007863
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45446996
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44163411
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43380507
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43343154
65AR_21909140_ChIP-Seq_LNCAP_Human1.43328171
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41771503
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41426076
68ER_23166858_ChIP-Seq_MCF-7_Human1.40572681
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39850991
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38051422
71TTF2_22483619_ChIP-Seq_HELA_Human1.37033688
72MYC_18940864_ChIP-ChIP_HL60_Human1.36547092
73SMAD4_21799915_ChIP-Seq_A2780_Human1.33964085
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32707080
75* GABP_19822575_ChIP-Seq_HepG2_Human1.31573799
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30939401
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30041905
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.29626429
79* XRN2_22483619_ChIP-Seq_HELA_Human1.29023143
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27160409
81CBP_20019798_ChIP-Seq_JUKART_Human1.27160409
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26991792
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25230990
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25146919
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.24853721
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22756679
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19616628
88* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15227494
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14477885
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14446926
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13977342
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12154812
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.12100020
94BCAT_22108803_ChIP-Seq_LS180_Human1.10968336
95* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10815465
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10441013
97STAT3_23295773_ChIP-Seq_U87_Human1.10307406
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10180042
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10107010
100IRF1_19129219_ChIP-ChIP_H3396_Human1.09256379
101TCF4_22108803_ChIP-Seq_LS180_Human1.09211873
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08440320
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.07549198
104AR_25329375_ChIP-Seq_VCAP_Human1.06888813
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06853980
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06557586
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06531908
108* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05856575
109* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05574023
110NANOG_19829295_ChIP-Seq_ESCs_Human1.03202329
111SOX2_19829295_ChIP-Seq_ESCs_Human1.03202329
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.02946793
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02150021
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01916033
115* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01813603
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01706427
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01333076
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01101505
119P53_22387025_ChIP-Seq_ESCs_Mouse1.00983890
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00956231
121STAT3_18555785_Chip-Seq_ESCs_Mouse1.00454398
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00257248
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.00018466
124IGF1R_20145208_ChIP-Seq_DFB_Human0.99760341
125TCF4_23295773_ChIP-Seq_U87_Human0.99560082
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.99558683
127NMYC_18555785_Chip-Seq_ESCs_Mouse0.99307485
128P300_18555785_Chip-Seq_ESCs_Mouse0.99305451
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99182560
130RNF2_27304074_Chip-Seq_NSC_Mouse0.98987519
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.98935113
132EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98255948
133TP53_22573176_ChIP-Seq_HFKS_Human0.97797503
134NANOG_16153702_ChIP-ChIP_HESCs_Human0.96928134
135POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96257559
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95939961
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95768514
138YY1_21170310_ChIP-Seq_MESCs_Mouse0.95007678
139POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94112310
140NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93008634
141SPI1_23547873_ChIP-Seq_NB4_Human0.92374883
142CIITA_25753668_ChIP-Seq_RAJI_Human0.92126305
143KDM5A_27292631_Chip-Seq_BREAST_Human0.91714517
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91331872
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90859937
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90134500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.96717821
2MP0008057_abnormal_DNA_replication3.95837603
3MP0010094_abnormal_chromosome_stability3.92243280
4MP0008058_abnormal_DNA_repair3.56569801
5MP0006292_abnormal_olfactory_placode3.21883154
6MP0008877_abnormal_DNA_methylation3.10137440
7MP0003111_abnormal_nucleus_morphology2.96497807
8MP0003077_abnormal_cell_cycle2.94604114
9MP0004957_abnormal_blastocyst_morpholog2.94279781
10MP0008007_abnormal_cellular_replicative2.63059325
11MP0002396_abnormal_hematopoietic_system2.12656369
12MP0000569_abnormal_digit_pigmentation2.08483204
13MP0001188_hyperpigmentation2.08041998
14MP0002163_abnormal_gland_morphology2.07043285
15MP0003763_abnormal_thymus_physiology1.94057165
16MP0003786_premature_aging1.83075445
17MP0003787_abnormal_imprinting1.79918628
18MP0005253_abnormal_eye_physiology1.78906723
19MP0006054_spinal_hemorrhage1.78229290
20MP0001529_abnormal_vocalization1.77885820
21MP0002751_abnormal_autonomic_nervous1.76591316
22MP0003123_paternal_imprinting1.75867796
23MP0001984_abnormal_olfaction1.73140620
24MP0003195_calcinosis1.70852760
25MP0005671_abnormal_response_to1.70470778
26MP0001293_anophthalmia1.69972521
27MP0005397_hematopoietic_system_phenotyp1.69771963
28MP0001545_abnormal_hematopoietic_system1.69771963
29MP0008932_abnormal_embryonic_tissue1.68591577
30MP0000566_synostosis1.66107956
31MP0003880_abnormal_central_pattern1.64054515
32MP0002102_abnormal_ear_morphology1.58436153
33MP0004808_abnormal_hematopoietic_stem1.56436983
34MP0009697_abnormal_copulation1.52543655
35MP0002638_abnormal_pupillary_reflex1.51993710
36MP0003122_maternal_imprinting1.48111398
37MP0008789_abnormal_olfactory_epithelium1.47906387
38MP0002233_abnormal_nose_morphology1.46757584
39MP0003121_genomic_imprinting1.45626810
40MP0000427_abnormal_hair_cycle1.39809890
41MP0001835_abnormal_antigen_presentation1.39728481
42MP0005551_abnormal_eye_electrophysiolog1.38959044
43MP0001986_abnormal_taste_sensitivity1.36984017
44MP0000647_abnormal_sebaceous_gland1.35832926
45MP0005187_abnormal_penis_morphology1.33851605
46MP0002398_abnormal_bone_marrow1.31616112
47MP0002277_abnormal_respiratory_mucosa1.28741909
48MP0009379_abnormal_foot_pigmentation1.28391673
49MP0000516_abnormal_urinary_system1.27008020
50MP0005367_renal/urinary_system_phenotyp1.27008020
51MP0005084_abnormal_gallbladder_morpholo1.26646710
52MP0003011_delayed_dark_adaptation1.25955929
53MP0000015_abnormal_ear_pigmentation1.25922178
54MP0002210_abnormal_sex_determination1.25164535
55MP0000703_abnormal_thymus_morphology1.24878976
56MP0002938_white_spotting1.24850777
57MP0002837_dystrophic_cardiac_calcinosis1.24827703
58MP0000490_abnormal_crypts_of1.23154910
59MP0005379_endocrine/exocrine_gland_phen1.22773263
60MP0000350_abnormal_cell_proliferation1.18020116
61MP0003567_abnormal_fetal_cardiomyocyte1.16741354
62MP0002736_abnormal_nociception_after1.15041394
63MP0002132_abnormal_respiratory_system1.14720013
64MP0005394_taste/olfaction_phenotype1.13594283
65MP0005499_abnormal_olfactory_system1.13594283
66MP0009333_abnormal_splenocyte_physiolog1.13160666
67MP0002095_abnormal_skin_pigmentation1.12915810
68MP0003186_abnormal_redox_activity1.12701091
69MP0003755_abnormal_palate_morphology1.11266420
70MP0003718_maternal_effect1.10971051
71MP0008995_early_reproductive_senescence1.10076286
72MP0004133_heterotaxia1.09902046
73MP0002009_preneoplasia1.09491428
74MP0000049_abnormal_middle_ear1.09476428
75MP0004215_abnormal_myocardial_fiber1.07005240
76MP0004142_abnormal_muscle_tone1.06595926
77MP0001286_abnormal_eye_development1.06406169
78MP0003950_abnormal_plasma_membrane1.05454088
79MP0002090_abnormal_vision1.05143982
80MP0004147_increased_porphyrin_level1.04609697
81MP0001929_abnormal_gametogenesis1.04484970
82MP0002234_abnormal_pharynx_morphology1.04134244
83MP0005395_other_phenotype1.03888426
84MP0001730_embryonic_growth_arrest1.03004575
85MP0002420_abnormal_adaptive_immunity1.02983724
86MP0001819_abnormal_immune_cell1.00844092
87MP0000716_abnormal_immune_system0.99709193
88MP0005391_vision/eye_phenotype0.99501906
89MP0001800_abnormal_humoral_immune0.99074282
90MP0001119_abnormal_female_reproductive0.98492310
91MP0000689_abnormal_spleen_morphology0.98445934
92MP0002722_abnormal_immune_system0.97725496
93MP0002084_abnormal_developmental_patter0.95520245
94MP0002160_abnormal_reproductive_system0.95249692
95MP0002452_abnormal_antigen_presenting0.94267945
96MP0000778_abnormal_nervous_system0.93937890
97MP0001145_abnormal_male_reproductive0.93491310
98MP0005409_darkened_coat_color0.93364057
99MP0000653_abnormal_sex_gland0.93008173
100MP0005075_abnormal_melanosome_morpholog0.91805832
101MP0000313_abnormal_cell_death0.91458915
102MP0003890_abnormal_embryonic-extraembry0.91313062
103MP0002282_abnormal_trachea_morphology0.90528187
104MP0010307_abnormal_tumor_latency0.89635816
105MP0009046_muscle_twitch0.89335527
106MP0002429_abnormal_blood_cell0.88880526
107MP0003119_abnormal_digestive_system0.88663626
108MP0002723_abnormal_immune_serum0.88614015
109MP0005310_abnormal_salivary_gland0.88069174
110MP0006072_abnormal_retinal_apoptosis0.86161918
111MP0005248_abnormal_Harderian_gland0.84812060
112MP0003806_abnormal_nucleotide_metabolis0.83696655
113MP0005174_abnormal_tail_pigmentation0.83636991
114MP0001486_abnormal_startle_reflex0.82517507
115MP0002019_abnormal_tumor_incidence0.82280539
116MP0009785_altered_susceptibility_to0.81897182
117MP0005171_absent_coat_pigmentation0.81257086
118MP0000372_irregular_coat_pigmentation0.80964623
119MP0006036_abnormal_mitochondrial_physio0.80000122
120MP0001299_abnormal_eye_distance/0.79923617
121MP0002148_abnormal_hypersensitivity_rea0.79855522
122MP0001324_abnormal_eye_pigmentation0.79653627
123MP0001905_abnormal_dopamine_level0.79121996
124MP0005389_reproductive_system_phenotype0.78768675
125MP0000383_abnormal_hair_follicle0.77313996
126MP0005195_abnormal_posterior_eye0.77222783
127MP0003136_yellow_coat_color0.76765176
128MP0000681_abnormal_thyroid_gland0.76647036
129MP0003937_abnormal_limbs/digits/tail_de0.75822449
130MP0006035_abnormal_mitochondrial_morpho0.75454282
131MP0000631_abnormal_neuroendocrine_gland0.75370535
132MP0005408_hypopigmentation0.75212465
133MP0001672_abnormal_embryogenesis/_devel0.74469453
134MP0005380_embryogenesis_phenotype0.74469453
135MP0001697_abnormal_embryo_size0.74371763
136MP0002752_abnormal_somatic_nervous0.72734587
137MP0001764_abnormal_homeostasis0.72432321
138MP0001485_abnormal_pinna_reflex0.71452748
139MP0006276_abnormal_autonomic_nervous0.70658770
140MP0002272_abnormal_nervous_system0.69217494
141MP0003698_abnormal_male_reproductive0.68970249
142MP0005646_abnormal_pituitary_gland0.68911131
143MP0001177_atelectasis0.68675559
144MP0003941_abnormal_skin_development0.68582996
145MP0003861_abnormal_nervous_system0.68108952
146MP0005000_abnormal_immune_tolerance0.68095012
147MP0001186_pigmentation_phenotype0.67721859
148MP0003938_abnormal_ear_development0.67389247
149MP0001790_abnormal_immune_system0.66830348
150MP0005387_immune_system_phenotype0.66830348
151MP0003183_abnormal_peptide_metabolism0.66380177
152MP0000685_abnormal_immune_system0.66323862
153MP0002085_abnormal_embryonic_tissue0.66273753
154MP0002405_respiratory_system_inflammati0.64360252

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.34197740
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.97386725
3Birth length less than 3rd percentile (HP:0003561)4.35132889
4Abnormality of chromosome stability (HP:0003220)3.47707441
5Abnormality of the preputium (HP:0100587)3.26857886
6Meckel diverticulum (HP:0002245)3.02430783
7Abnormality of DNA repair (HP:0003254)2.98759913
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.93311885
9Pancreatic fibrosis (HP:0100732)2.84599636
10Duplicated collecting system (HP:0000081)2.83359554
11Ectopic kidney (HP:0000086)2.79978432
12Abnormality of the ileum (HP:0001549)2.78839349
13Methylmalonic acidemia (HP:0002912)2.77793147
14Reticulocytopenia (HP:0001896)2.77508434
15Acute necrotizing encephalopathy (HP:0006965)2.72002417
16Nephronophthisis (HP:0000090)2.71881216
17Abnormal hair whorl (HP:0010721)2.71857905
18Abnormality of the renal collecting system (HP:0004742)2.64723064
19Congenital primary aphakia (HP:0007707)2.60204569
20Myelodysplasia (HP:0002863)2.55936556
21Volvulus (HP:0002580)2.54915496
22Patellar aplasia (HP:0006443)2.54529018
23Gait imbalance (HP:0002141)2.53654581
24Pancreatic cysts (HP:0001737)2.52255421
25Intestinal atresia (HP:0011100)2.51298867
26Progressive macrocephaly (HP:0004481)2.50114376
27Aplastic anemia (HP:0001915)2.48732793
28Acute encephalopathy (HP:0006846)2.43432657
29Oligodactyly (hands) (HP:0001180)2.42415755
30Increased CSF lactate (HP:0002490)2.42163953
31Tubulointerstitial nephritis (HP:0001970)2.42153305
32Aplasia/Hypoplasia of the patella (HP:0006498)2.37151860
33Clubbing of toes (HP:0100760)2.36545664
34Abnormality of the labia minora (HP:0012880)2.36531145
35Nephrogenic diabetes insipidus (HP:0009806)2.34219416
36Microvesicular hepatic steatosis (HP:0001414)2.33588103
37Thyroiditis (HP:0100646)2.32999280
38Abnormality of the renal cortex (HP:0011035)2.32555936
39Abnormality of the renal medulla (HP:0100957)2.32406169
40Mitochondrial inheritance (HP:0001427)2.32193367
41Genital tract atresia (HP:0001827)2.31646679
42Median cleft lip (HP:0000161)2.31160702
43Bone marrow hypocellularity (HP:0005528)2.29721353
44Lipid accumulation in hepatocytes (HP:0006561)2.29348277
45Capillary hemangiomas (HP:0005306)2.26781793
46Abnormality of the columella (HP:0009929)2.25411277
47Prostate neoplasm (HP:0100787)2.24676739
48Renal cortical cysts (HP:0000803)2.23666732
49Abnormal mitochondria in muscle tissue (HP:0008316)2.22621613
50Abnormal spermatogenesis (HP:0008669)2.22058130
51Abnormal lung lobation (HP:0002101)2.19738640
52Pallor (HP:0000980)2.18840677
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.17081617
54Self-mutilation (HP:0000742)2.16557904
55Breast hypoplasia (HP:0003187)2.15855764
56Vaginal atresia (HP:0000148)2.15572346
57Severe combined immunodeficiency (HP:0004430)2.13451203
58Bifid tongue (HP:0010297)2.12668865
59Facial hemangioma (HP:0000329)2.10844486
60Small intestinal stenosis (HP:0012848)2.09044837
61Duodenal stenosis (HP:0100867)2.09044837
62Sloping forehead (HP:0000340)2.08378419
63Postaxial hand polydactyly (HP:0001162)2.07525474
64Short tibia (HP:0005736)2.07237722
65True hermaphroditism (HP:0010459)2.07074871
66Small hand (HP:0200055)2.06936105
67Acanthocytosis (HP:0001927)2.06526379
68Chronic hepatic failure (HP:0100626)2.03783084
69IgM deficiency (HP:0002850)2.03457548
70Abnormality of alanine metabolism (HP:0010916)2.03259074
71Hyperalaninemia (HP:0003348)2.03259074
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03259074
73Supernumerary spleens (HP:0009799)2.03099858
74Irregular epiphyses (HP:0010582)2.02153724
75Carpal bone hypoplasia (HP:0001498)2.01874562
7611 pairs of ribs (HP:0000878)2.00196240
77Absent thumb (HP:0009777)1.98291705
78Sclerocornea (HP:0000647)1.97431242
79IgG deficiency (HP:0004315)1.96852962
80Acute lymphatic leukemia (HP:0006721)1.96696873
81Abnormality of B cell number (HP:0010975)1.96002810
82B lymphocytopenia (HP:0010976)1.96002810
83Exertional dyspnea (HP:0002875)1.94692387
84Dyskinesia (HP:0100660)1.94514593
85Anencephaly (HP:0002323)1.93995109
86Triphalangeal thumb (HP:0001199)1.91927435
87Methylmalonic aciduria (HP:0012120)1.90646241
88Hepatocellular necrosis (HP:0001404)1.90267263
89Abnormal number of erythroid precursors (HP:0012131)1.89286259
90Absent radius (HP:0003974)1.89115767
91Acute myeloid leukemia (HP:0004808)1.87665060
92Hyperglycinemia (HP:0002154)1.87620911
93Type I transferrin isoform profile (HP:0003642)1.86885995
94Short middle phalanx of the 5th finger (HP:0004220)1.86041282
95Premature graying of hair (HP:0002216)1.86005093
96Poor coordination (HP:0002370)1.85866619
97Abnormality of cells of the erythroid lineage (HP:0012130)1.85659067
98Metaphyseal dysplasia (HP:0100255)1.83698478
99Dandy-Walker malformation (HP:0001305)1.83634068
100Narrow forehead (HP:0000341)1.82711897
101Congenital, generalized hypertrichosis (HP:0004540)1.82185232
102Oculomotor apraxia (HP:0000657)1.81560746
1033-Methylglutaconic aciduria (HP:0003535)1.81388051
104Hypoplastic iliac wings (HP:0002866)1.81386673
105Nephroblastoma (Wilms tumor) (HP:0002667)1.80099565
106Aganglionic megacolon (HP:0002251)1.79610389
107Long clavicles (HP:0000890)1.79240125
108Hepatic necrosis (HP:0002605)1.78951357
109Abnormality of the fingertips (HP:0001211)1.78001495
110Molar tooth sign on MRI (HP:0002419)1.77993493
111Abnormality of midbrain morphology (HP:0002418)1.77993493
112Azoospermia (HP:0000027)1.77924250
113Lymphoma (HP:0002665)1.77341553
114Gonadotropin excess (HP:0000837)1.77164026
115Astigmatism (HP:0000483)1.75147976
116Cerebral edema (HP:0002181)1.74631402
117Cystic liver disease (HP:0006706)1.74154601
118Decreased testicular size (HP:0008734)1.73996112
119Impulsivity (HP:0100710)1.73546961
120Disinhibition (HP:0000734)1.73230349
121Agnosia (HP:0010524)1.72965424
122Absent forearm bone (HP:0003953)1.72336543
123Aplasia involving forearm bones (HP:0009822)1.72336543
124Abnormality of vitamin B metabolism (HP:0004340)1.71821097
125Renal Fanconi syndrome (HP:0001994)1.71806710
126Increased hepatocellular lipid droplets (HP:0006565)1.71108330
127Hypothermia (HP:0002045)1.71052145
128Abnormality of serum amino acid levels (HP:0003112)1.70556534
129Embryonal renal neoplasm (HP:0011794)1.69181693
130Optic nerve hypoplasia (HP:0000609)1.69027047
131Abnormality of methionine metabolism (HP:0010901)1.68795587
132Respiratory difficulties (HP:0002880)1.68553299
133Glioma (HP:0009733)1.68194176
134Personality changes (HP:0000751)1.67142602
135Male pseudohermaphroditism (HP:0000037)1.67075065
136Gastrointestinal atresia (HP:0002589)1.66835998
137Short thumb (HP:0009778)1.66796053
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66434444
139Abnormality of the prostate (HP:0008775)1.65775765
140Inappropriate behavior (HP:0000719)1.65564799
141Protruding tongue (HP:0010808)1.64591788
142Progressive inability to walk (HP:0002505)1.64436604
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.64106206
144Congenital hepatic fibrosis (HP:0002612)1.63808122
145Abnormality of the duodenum (HP:0002246)1.63435136
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63413429
147Oral leukoplakia (HP:0002745)1.62932055
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.62832702
149Rhabdomyosarcoma (HP:0002859)1.62704340
150Pancreatic islet-cell hyperplasia (HP:0004510)1.62671870
151Medial flaring of the eyebrow (HP:0010747)1.62339140
152Broad foot (HP:0001769)1.62083275
153Septo-optic dysplasia (HP:0100842)1.61563680
154Neoplasm of the oral cavity (HP:0100649)1.61511378
155Thrombocytosis (HP:0001894)1.61305405
156Colon cancer (HP:0003003)1.61113986
157Abnormality of the carotid arteries (HP:0005344)1.60901006
158Prominent nasal bridge (HP:0000426)1.60792653
159Bile duct proliferation (HP:0001408)1.60646092
160Abnormal biliary tract physiology (HP:0012439)1.60646092
161Preaxial hand polydactyly (HP:0001177)1.60524495
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.59926449
163Combined immunodeficiency (HP:0005387)1.59621652
164Cerebral hypomyelination (HP:0006808)1.58827723
165Abnormality of cochlea (HP:0000375)1.58525860
166Pulmonary fibrosis (HP:0002206)1.57717800
167Postaxial foot polydactyly (HP:0001830)1.57517309
168Horseshoe kidney (HP:0000085)1.57168112
169Abnormality of the anterior horn cell (HP:0006802)1.56535737
170Degeneration of anterior horn cells (HP:0002398)1.56535737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.22676130
2SRPK13.21044517
3CDC73.17401811
4TRIM282.71900813
5WNK32.57582194
6EIF2AK12.44568288
7MKNK22.40619010
8BUB12.40199654
9VRK12.36811054
10WEE12.28356619
11NUAK12.24937242
12MKNK12.23380623
13STK162.18450094
14EIF2AK32.16954491
15ZAK2.13622647
16ACVR1B2.12873377
17MAP4K22.11572755
18PLK42.10049731
19TXK2.02071139
20PNCK2.01465706
21CASK1.94930766
22CDK81.88706655
23TNIK1.81579615
24MAP3K41.77732764
25EIF2AK21.75288823
26PLK31.73467479
27BRSK21.73079446
28CCNB11.53097462
29PLK11.52933984
30TEC1.52926917
31NEK21.51540275
32ATR1.46557954
33DYRK31.43949198
34TTK1.35514152
35YES11.35380645
36TSSK61.28892278
37MST41.28374121
38CHEK21.28316230
39AURKB1.26387299
40BCR1.26042451
41CDK31.25954668
42STK391.25388515
43ERBB31.21745560
44BMPR1B1.17596810
45DYRK21.16833938
46NME21.11502482
47SIK31.10998024
48ADRBK21.07521887
49CSNK1G11.07209027
50BMPR21.07032582
51JAK31.06539495
52MAP2K71.05650878
53NLK1.04946005
54MAPK131.04898164
55CSNK1G21.04095154
56ATM0.97881618
57BRD40.95215190
58OXSR10.94838237
59AKT30.94187641
60MAP4K10.93522516
61VRK20.91786386
62MAP3K120.90289277
63MARK10.89311992
64MELK0.87904335
65CHEK10.85900748
66PLK20.85733429
67CSNK1A1L0.85539201
68CDK70.83514161
69BRAF0.81873017
70IRAK40.81235473
71CLK10.80963291
72STK38L0.79290729
73PAK30.78917253
74MAP3K60.77739035
75EPHA40.77411311
76MINK10.75568563
77FRK0.73457203
78GRK70.73379635
79MUSK0.71604142
80STK100.70275828
81NEK60.70078368
82PRKCE0.69556776
83SGK20.69101128
84TLK10.68907769
85BRSK10.68727202
86DYRK1A0.67841558
87GRK10.65503940
88PINK10.63084590
89CSNK2A10.61414376
90PRKCG0.61236281
91CSNK2A20.60682901
92MAP3K140.59983497
93TAF10.59317895
94RPS6KA40.58778613
95RIPK40.58343691
96WNK40.57241765
97INSRR0.56213854
98STK40.55991951
99BTK0.55048252
100AURKA0.54928787
101STK30.54788028
102CDK10.54548398
103CDK20.53973895
104PIM10.53690703
105STK240.52733668
106RPS6KA50.51869807
107CDK40.49748849
108LYN0.47910103
109SYK0.47170226
110CSNK1E0.47035755
111LCK0.43832125
112FGFR10.43468999
113IKBKB0.43287175
114FGFR20.43113627
115PASK0.42543343
116MARK30.42092211
117PBK0.42038633
118MAPKAPK50.40557250
119LATS10.40541414
120PDK20.39884496
121PRKACB0.39521534
122RPS6KB20.38594926
123CDK90.38301422
124NME10.37981193
125PRKDC0.37915250
126TRPM70.37602422
127CDK190.37592534
128TGFBR10.37499160
129CSNK1G30.35417632
130CDK120.34383369
131CSNK1D0.34081557
132PRKG10.33934873
133CAMK2A0.33421486
134TIE10.32033480
135BCKDK0.31376664
136CSNK1A10.29920497
137PKN10.28987545

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.76533477
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36139308
3DNA replication_Homo sapiens_hsa030303.24128638
4Non-homologous end-joining_Homo sapiens_hsa034503.05781638
5Mismatch repair_Homo sapiens_hsa034302.96213654
6Homologous recombination_Homo sapiens_hsa034402.79998930
7Spliceosome_Homo sapiens_hsa030402.78461107
8Fanconi anemia pathway_Homo sapiens_hsa034602.77773199
9Basal transcription factors_Homo sapiens_hsa030222.70356562
10Nucleotide excision repair_Homo sapiens_hsa034202.66638908
11Proteasome_Homo sapiens_hsa030502.50105829
12Propanoate metabolism_Homo sapiens_hsa006402.46434277
13Cell cycle_Homo sapiens_hsa041102.42145536
14RNA degradation_Homo sapiens_hsa030182.34219547
15RNA transport_Homo sapiens_hsa030132.31313611
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30554094
17Base excision repair_Homo sapiens_hsa034102.30288121
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.20050616
19Ribosome_Homo sapiens_hsa030102.14305547
20Pyrimidine metabolism_Homo sapiens_hsa002402.07127958
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89772862
22Steroid biosynthesis_Homo sapiens_hsa001001.79806658
23mRNA surveillance pathway_Homo sapiens_hsa030151.76819545
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61426616
25Protein export_Homo sapiens_hsa030601.61393919
26Purine metabolism_Homo sapiens_hsa002301.49909311
27Primary immunodeficiency_Homo sapiens_hsa053401.48058245
28p53 signaling pathway_Homo sapiens_hsa041151.45538775
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.42915234
30Selenocompound metabolism_Homo sapiens_hsa004501.37794618
31Butanoate metabolism_Homo sapiens_hsa006501.34797485
32Herpes simplex infection_Homo sapiens_hsa051681.31253441
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28554043
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22678033
35Epstein-Barr virus infection_Homo sapiens_hsa051691.16358443
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16342024
37Pyruvate metabolism_Homo sapiens_hsa006201.15640483
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.11803520
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08820297
40Phototransduction_Homo sapiens_hsa047441.03637530
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01624469
42One carbon pool by folate_Homo sapiens_hsa006701.00365027
43Nicotine addiction_Homo sapiens_hsa050330.99662664
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.98691705
45Measles_Homo sapiens_hsa051620.98401576
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.96912122
47Nitrogen metabolism_Homo sapiens_hsa009100.96900982
48Allograft rejection_Homo sapiens_hsa053300.94473946
49Peroxisome_Homo sapiens_hsa041460.92924616
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92368060
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91981451
52Oocyte meiosis_Homo sapiens_hsa041140.87425442
53Graft-versus-host disease_Homo sapiens_hsa053320.86809367
54Folate biosynthesis_Homo sapiens_hsa007900.86342010
55Autoimmune thyroid disease_Homo sapiens_hsa053200.85561851
56Fatty acid elongation_Homo sapiens_hsa000620.85099635
57Hematopoietic cell lineage_Homo sapiens_hsa046400.84231331
58Systemic lupus erythematosus_Homo sapiens_hsa053220.82886015
59Caffeine metabolism_Homo sapiens_hsa002320.82762627
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81137408
61Huntingtons disease_Homo sapiens_hsa050160.79586199
62Vitamin B6 metabolism_Homo sapiens_hsa007500.77932935
63Glutathione metabolism_Homo sapiens_hsa004800.76311370
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74581910
65beta-Alanine metabolism_Homo sapiens_hsa004100.74214402
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72465729
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71646489
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69568077
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68975179
70Cardiac muscle contraction_Homo sapiens_hsa042600.68453435
71Antigen processing and presentation_Homo sapiens_hsa046120.67559544
72Sulfur metabolism_Homo sapiens_hsa009200.65483386
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65275423
74Viral carcinogenesis_Homo sapiens_hsa052030.64915369
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63959931
76Tryptophan metabolism_Homo sapiens_hsa003800.63517558
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62772308
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62680899
79Type I diabetes mellitus_Homo sapiens_hsa049400.61921458
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61786878
81Influenza A_Homo sapiens_hsa051640.61499465
82Metabolic pathways_Homo sapiens_hsa011000.61025982
83Circadian rhythm_Homo sapiens_hsa047100.59929751
84Oxidative phosphorylation_Homo sapiens_hsa001900.57521184
85Hepatitis B_Homo sapiens_hsa051610.56984002
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56430831
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54801837
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.53923128
89HTLV-I infection_Homo sapiens_hsa051660.53377898
90Rheumatoid arthritis_Homo sapiens_hsa053230.53269578
91Hedgehog signaling pathway_Homo sapiens_hsa043400.52791129
92Alcoholism_Homo sapiens_hsa050340.50206334
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47764497
94Fatty acid metabolism_Homo sapiens_hsa012120.47702369
95Fatty acid degradation_Homo sapiens_hsa000710.47170525
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.46542415
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45726236
98Olfactory transduction_Homo sapiens_hsa047400.45722285
99Sphingolipid metabolism_Homo sapiens_hsa006000.45149169
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44993279
101GABAergic synapse_Homo sapiens_hsa047270.44083184
102T cell receptor signaling pathway_Homo sapiens_hsa046600.42825451
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42753157
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42039370
105Ether lipid metabolism_Homo sapiens_hsa005650.39760395
106Leishmaniasis_Homo sapiens_hsa051400.38960464
107Hippo signaling pathway_Homo sapiens_hsa043900.38619799
108Basal cell carcinoma_Homo sapiens_hsa052170.38015006
109Chemical carcinogenesis_Homo sapiens_hsa052040.37694160
110Retinol metabolism_Homo sapiens_hsa008300.37492849
111Asthma_Homo sapiens_hsa053100.37266138
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37045254
113Colorectal cancer_Homo sapiens_hsa052100.37035908
114Regulation of autophagy_Homo sapiens_hsa041400.35732487
115TGF-beta signaling pathway_Homo sapiens_hsa043500.35295227
116Morphine addiction_Homo sapiens_hsa050320.35170815
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34910881
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33936618
119Parkinsons disease_Homo sapiens_hsa050120.33897534
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33281582
121Serotonergic synapse_Homo sapiens_hsa047260.33264600
122N-Glycan biosynthesis_Homo sapiens_hsa005100.31859843
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30848579
124Alzheimers disease_Homo sapiens_hsa050100.30814935
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29808530
126Dopaminergic synapse_Homo sapiens_hsa047280.28933572
127Taste transduction_Homo sapiens_hsa047420.28382923
128MicroRNAs in cancer_Homo sapiens_hsa052060.28297284
129Apoptosis_Homo sapiens_hsa042100.27555487
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26595230
131Chemokine signaling pathway_Homo sapiens_hsa040620.26286910
132Wnt signaling pathway_Homo sapiens_hsa043100.25099459
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24582374
134Shigellosis_Homo sapiens_hsa051310.24024367
135Linoleic acid metabolism_Homo sapiens_hsa005910.23818047
136Amphetamine addiction_Homo sapiens_hsa050310.23508945
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.22422188
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22320905
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22117098
140FoxO signaling pathway_Homo sapiens_hsa040680.20741694
141Collecting duct acid secretion_Homo sapiens_hsa049660.19851795
142Arachidonic acid metabolism_Homo sapiens_hsa005900.19095247
143B cell receptor signaling pathway_Homo sapiens_hsa046620.18357976
144Phagosome_Homo sapiens_hsa041450.18069540
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18028145
146TNF signaling pathway_Homo sapiens_hsa046680.17988925
147Arginine and proline metabolism_Homo sapiens_hsa003300.17051445
148Prostate cancer_Homo sapiens_hsa052150.16525362
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16286251
150Pathways in cancer_Homo sapiens_hsa052000.16093775
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15349514
152Tuberculosis_Homo sapiens_hsa051520.15154190
153Glutamatergic synapse_Homo sapiens_hsa047240.14558091

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