PPIP5K1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)5.84062560
2polyketide metabolic process (GO:0030638)5.84062560
3doxorubicin metabolic process (GO:0044598)5.84062560
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.16776973
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.13147712
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.98936159
7vocalization behavior (GO:0071625)4.95016257
8synaptic vesicle maturation (GO:0016188)4.76115614
9cytoskeletal anchoring at plasma membrane (GO:0007016)4.67611551
10locomotory exploration behavior (GO:0035641)4.63261162
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.47751664
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.45801814
13neuronal action potential propagation (GO:0019227)4.44364512
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38775003
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.26793484
16regulation of synaptic vesicle exocytosis (GO:2000300)4.21298600
17positive regulation of synapse maturation (GO:0090129)4.15223839
18regulation of glutamate receptor signaling pathway (GO:1900449)4.10167065
19regulation of ARF protein signal transduction (GO:0032012)4.08334866
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05137427
21aminoglycoside antibiotic metabolic process (GO:0030647)3.92316743
22synaptic transmission, glutamatergic (GO:0035249)3.92002498
23regulation of synaptic vesicle transport (GO:1902803)3.89037499
24glycine transport (GO:0015816)3.85251509
25synaptic vesicle exocytosis (GO:0016079)3.85164888
26desmosome organization (GO:0002934)3.82781245
27glutamate receptor signaling pathway (GO:0007215)3.80977223
28cellular potassium ion homeostasis (GO:0030007)3.80151265
29glutamate secretion (GO:0014047)3.69946142
30membrane depolarization during action potential (GO:0086010)3.69373848
31neuron-neuron synaptic transmission (GO:0007270)3.68688298
32positive regulation of neurotransmitter secretion (GO:0001956)3.68444470
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.61313034
34activation of Rac GTPase activity (GO:0032863)3.61029933
35cell communication by electrical coupling (GO:0010644)3.55679194
36neurotransmitter secretion (GO:0007269)3.53815390
37cerebellar Purkinje cell differentiation (GO:0021702)3.52178838
38positive regulation of neurotransmitter transport (GO:0051590)3.50653306
39sodium ion export (GO:0071436)3.48991689
40long-term memory (GO:0007616)3.48347657
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46197623
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41566878
43proline transport (GO:0015824)3.41510805
44protein localization to synapse (GO:0035418)3.38095182
45cerebellar granule cell differentiation (GO:0021707)3.37946103
46positive regulation of membrane potential (GO:0045838)3.36908927
47membrane hyperpolarization (GO:0060081)3.36529847
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33811013
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32077182
50regulation of synapse structural plasticity (GO:0051823)3.31638005
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29514358
52regulation of neuronal synaptic plasticity (GO:0048168)3.28895544
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26671681
54synaptic vesicle endocytosis (GO:0048488)3.25507919
55response to pheromone (GO:0019236)3.25395587
56regulation of neurotransmitter secretion (GO:0046928)3.25189104
57potassium ion import (GO:0010107)3.24906131
58regulation of postsynaptic membrane potential (GO:0060078)3.23662098
59regulation of voltage-gated calcium channel activity (GO:1901385)3.22820095
60regulation of synapse maturation (GO:0090128)3.22558500
61L-amino acid import (GO:0043092)3.19713143
62neuron cell-cell adhesion (GO:0007158)3.18515524
63negative regulation of dendrite morphogenesis (GO:0050774)3.18145519
64auditory receptor cell stereocilium organization (GO:0060088)3.16306333
65membrane depolarization (GO:0051899)3.16148645
66neuronal ion channel clustering (GO:0045161)3.15876742
67regulation of cell communication by electrical coupling (GO:0010649)3.15640975
68regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.15511815
69regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.14547638
70exploration behavior (GO:0035640)3.14213305
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.13802241
72dendritic spine morphogenesis (GO:0060997)3.13622065
73neurotransmitter transport (GO:0006836)3.13122512
74neurotransmitter-gated ion channel clustering (GO:0072578)3.09145336
75gamma-aminobutyric acid transport (GO:0015812)3.09085717
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07997093
77detection of calcium ion (GO:0005513)3.07711955
78neuromuscular process controlling posture (GO:0050884)3.06935775
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06322298
80positive regulation of potassium ion transmembrane transport (GO:1901381)3.05599529
81transmission of nerve impulse (GO:0019226)3.05588628
82regulation of neurotransmitter transport (GO:0051588)3.03794083
83myelin maintenance (GO:0043217)3.03459559
84dicarboxylic acid biosynthetic process (GO:0043650)2.98988356
85potassium ion homeostasis (GO:0055075)2.97066384
86regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.96158097
87cell communication involved in cardiac conduction (GO:0086065)2.95984667
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95048895
89mannose metabolic process (GO:0006013)2.94874990
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93363183
91response to auditory stimulus (GO:0010996)2.89424515
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88305845
93calcium ion import (GO:0070509)2.87953228
94positive regulation of potassium ion transport (GO:0043268)2.86767455
95activation of protein kinase A activity (GO:0034199)2.86734359
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.86048544
97negative regulation of macroautophagy (GO:0016242)2.85814284
98amino acid import (GO:0043090)2.84722545
99startle response (GO:0001964)2.83837098
100adult walking behavior (GO:0007628)2.83622803
101long term synaptic depression (GO:0060292)2.83292218
102neuromuscular process controlling balance (GO:0050885)2.81439614
103regulation of vesicle fusion (GO:0031338)2.80901108
104regulation of clathrin-mediated endocytosis (GO:2000369)2.80019376
105neuromuscular synaptic transmission (GO:0007274)2.79824057
106regulation of membrane repolarization (GO:0060306)2.79784616
107auditory behavior (GO:0031223)2.78484442
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77609169
109regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.76317579
110regulation of neurotransmitter levels (GO:0001505)2.75517444
111cardiac conduction (GO:0061337)2.74542635
112regulation of calcium ion transmembrane transporter activity (GO:1901019)2.74379916
113regulation of calcium ion transmembrane transport (GO:1903169)2.74379916
114positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.73392054
115calcium ion-dependent exocytosis (GO:0017156)2.73235924
116macroautophagy (GO:0016236)2.73035260
117layer formation in cerebral cortex (GO:0021819)2.73011679
118positive regulation of dendritic spine morphogenesis (GO:0061003)2.71313122
119chemosensory behavior (GO:0007635)2.71073939
120COPI coating of Golgi vesicle (GO:0048205)2.69282721
121Golgi transport vesicle coating (GO:0048200)2.69282721
122positive regulation of CREB transcription factor activity (GO:0032793)2.68838184
123peptidyl-tyrosine autophosphorylation (GO:0038083)2.66968724
124regulation of synaptic plasticity (GO:0048167)2.66615236
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.65015711
126regulation of histone H3-K27 methylation (GO:0061085)2.62823215
127carnitine shuttle (GO:0006853)2.62201508
128regulation of ARF GTPase activity (GO:0032312)2.58952426
129cellular sodium ion homeostasis (GO:0006883)2.57937389
130iron ion import (GO:0097286)2.55130605
131hemidesmosome assembly (GO:0031581)2.54767877
132regulation of cholesterol homeostasis (GO:2000188)2.52739438
133negative regulation of erythrocyte differentiation (GO:0045647)2.51791812
134carnitine transport (GO:0015879)2.51436561
135amino-acid betaine transport (GO:0015838)2.51436561
136biotin metabolic process (GO:0006768)2.51271439
137regulation of heart rate by cardiac conduction (GO:0086091)2.48661530
138bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47947899
139vesicle transport along microtubule (GO:0047496)2.46936300
140Golgi to endosome transport (GO:0006895)2.41930919
141dendritic spine organization (GO:0097061)2.41342345
142regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.41035377
143carnitine transmembrane transport (GO:1902603)2.38596351
144creatine metabolic process (GO:0006600)2.37977454
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37029448
146quaternary ammonium group transport (GO:0015697)2.37023327
147positive regulation of vesicle fusion (GO:0031340)2.36112745
148positive regulation of dendritic spine development (GO:0060999)2.35008159
149regulation of fatty acid beta-oxidation (GO:0031998)2.33684248
150G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.31971198
151sodium ion transmembrane transport (GO:0035725)2.30273096
152skeletal muscle adaptation (GO:0043501)2.27410063
153positive regulation of Rap GTPase activity (GO:0032854)2.27027623
154fatty acid transmembrane transport (GO:1902001)2.26276137
155positive regulation of dendrite development (GO:1900006)2.24245186
156positive regulation of Rac GTPase activity (GO:0032855)2.23911636
157cerebellar Purkinje cell layer development (GO:0021680)2.23866737

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14504162
2GBX2_23144817_ChIP-Seq_PC3_Human3.55622618
3DROSHA_22980978_ChIP-Seq_HELA_Human2.94482107
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81705018
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80158327
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72732312
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.70718821
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54809240
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54809240
10REST_21632747_ChIP-Seq_MESCs_Mouse2.51551566
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.46100642
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33864970
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27649335
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27582089
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.26731472
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25130154
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21940458
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.20840585
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.18815507
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16987733
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.13827394
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11180864
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.09129158
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04415995
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02640796
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.00989116
27LXR_22292898_ChIP-Seq_THP-1_Human2.00983812
28KDM2B_26808549_Chip-Seq_K562_Human1.98844794
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91475314
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.87182493
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.84067694
32RACK7_27058665_Chip-Seq_MCF-7_Human1.83525274
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.81249026
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80225430
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76625670
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.75501704
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73933919
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73745705
39ZNF263_19887448_ChIP-Seq_K562_Human1.73059955
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70550573
41SMC4_20622854_ChIP-Seq_HELA_Human1.69750880
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.69348774
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66469920
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64352109
45SMAD4_21799915_ChIP-Seq_A2780_Human1.61977915
46CREB1_26743006_Chip-Seq_LNCaP_Human1.56786016
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56729948
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54852371
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52460678
50TET1_21490601_ChIP-Seq_MESCs_Mouse1.49815992
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49622095
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49434411
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45923635
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45369525
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44161837
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43636678
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.43630590
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42151826
59AR_21572438_ChIP-Seq_LNCaP_Human1.40816849
60TCF7_22412390_ChIP-Seq_EML_Mouse1.40676709
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.40257960
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37008721
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35312340
64GATA1_19941826_ChIP-Seq_K562_Human1.35256754
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.34448492
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34230785
67KDM2B_26808549_Chip-Seq_DND41_Human1.32930633
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.32408083
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31700416
70P68_20966046_ChIP-Seq_HELA_Human1.31044465
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30924612
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30677693
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30654392
74TP63_22573176_ChIP-Seq_HFKS_Human1.30423757
75P300_19829295_ChIP-Seq_ESCs_Human1.30402958
76STAT3_23295773_ChIP-Seq_U87_Human1.29655351
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29019734
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27020791
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.26039762
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25716931
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25293527
82TAF15_26573619_Chip-Seq_HEK293_Human1.24155800
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23736928
84TCF4_23295773_ChIP-Seq_U87_Human1.22733531
85CTCF_27219007_Chip-Seq_Bcells_Human1.21904235
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21862957
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.21327691
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21299795
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21070199
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.19769016
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19202376
92AR_25329375_ChIP-Seq_VCAP_Human1.18405768
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.18390766
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18290322
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18054328
96ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17747850
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17649681
98KLF5_25053715_ChIP-Seq_YYC3_Human1.16021033
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15016271
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.14895241
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.14216678
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13943408
103AR_19668381_ChIP-Seq_PC3_Human1.13708589
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13356355
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12712935
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12573676
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.12473621
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11943062
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11685495
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11611120
111GATA6_25053715_ChIP-Seq_YYC3_Human1.11070210
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10620058
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10414525
114POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10336060
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10010843
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09517084
117ZNF274_21170338_ChIP-Seq_K562_Hela1.09290573
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08393251
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.07893473
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07464005
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.07095785
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07065800
123GATA2_19941826_ChIP-Seq_K562_Human1.06795364
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.06696117
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06173396
126MYC_22102868_ChIP-Seq_BL_Human1.06137781
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06086224
128TP53_23651856_ChIP-Seq_MEFs_Mouse1.05769965
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05612257
130TP53_16413492_ChIP-PET_HCT116_Human1.05571082
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04620404
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04555935
133GATA1_22025678_ChIP-Seq_K562_Human1.04205824
134PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02516970
135RUNX2_22187159_ChIP-Seq_PCA_Human1.02290252
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01650473
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01571148
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01090009
139P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00997745
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00309067
141ER_23166858_ChIP-Seq_MCF-7_Human1.00056912
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99912255
143VDR_22108803_ChIP-Seq_LS180_Human0.99819259
144OCT4_19829295_ChIP-Seq_ESCs_Human0.99592455
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.98811187
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.98810816
147RXR_22108803_ChIP-Seq_LS180_Human0.98782573
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98782158
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98773535
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97517500
151TBX20_22328084_ChIP-Seq_HEART_Mouse0.97311748
152TBX20_22080862_ChIP-Seq_HEART_Mouse0.97311748
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96898997
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.96229175
155* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96003062
156CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95677138
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.94682723
158MITF_21258399_ChIP-Seq_MELANOMA_Human0.94596358
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94368058
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94263631
161TBL1_22424771_ChIP-Seq_293T_Human0.93896111
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93833453
163AHR_22903824_ChIP-Seq_MCF-7_Human0.93466117
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.93153427
165P53_22387025_ChIP-Seq_ESCs_Mouse0.92916725
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92797871
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92797871
168RNF2_27304074_Chip-Seq_NSC_Mouse0.92465291
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.92369924
170UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91760641
171MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90804430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.91265441
2MP0010234_abnormal_vibrissa_follicle4.85160849
3MP0003880_abnormal_central_pattern3.75172988
4MP0009046_muscle_twitch3.33950210
5MP0003635_abnormal_synaptic_transmissio3.26533471
6MP0005423_abnormal_somatic_nervous3.19438254
7MP0009745_abnormal_behavioral_response2.83857518
8MP0004270_analgesia2.70019331
9MP0001486_abnormal_startle_reflex2.66194131
10MP0002064_seizures2.65338821
11MP0003646_muscle_fatigue2.63796126
12MP0002272_abnormal_nervous_system2.56934618
13MP0002063_abnormal_learning/memory/cond2.40930829
14MP0002572_abnormal_emotion/affect_behav2.34547567
15MP0001968_abnormal_touch/_nociception2.30417762
16MP0002734_abnormal_mechanical_nocicepti2.25315907
17MP0001501_abnormal_sleep_pattern2.23552100
18MP0002822_catalepsy2.21698050
19MP0003329_amyloid_beta_deposits2.20846937
20MP0005645_abnormal_hypothalamus_physiol2.20605139
21MP0003705_abnormal_hypodermis_morpholog2.20072984
22MP0003879_abnormal_hair_cell2.17940574
23MP0004264_abnormal_extraembryonic_tissu2.14497728
24MP0000579_abnormal_nail_morphology2.05567326
25MP0004145_abnormal_muscle_electrophysio2.04021596
26MP0002837_dystrophic_cardiac_calcinosis1.98334010
27MP0003878_abnormal_ear_physiology1.95730113
28MP0005377_hearing/vestibular/ear_phenot1.95730113
29MP0001440_abnormal_grooming_behavior1.95459194
30MP0008569_lethality_at_weaning1.94872776
31MP0008004_abnormal_stomach_pH1.92842582
32MP0002735_abnormal_chemical_nociception1.89367294
33MP0000751_myopathy1.85653186
34MP0002067_abnormal_sensory_capabilities1.85302756
35MP0003172_abnormal_lysosome_physiology1.84542260
36MP0005551_abnormal_eye_electrophysiolog1.81833878
37MP0005451_abnormal_body_composition1.74892303
38MP0004147_increased_porphyrin_level1.72231570
39MP0004924_abnormal_behavior1.71409789
40MP0005386_behavior/neurological_phenoty1.71409789
41MP0005646_abnormal_pituitary_gland1.71106427
42MP0004215_abnormal_myocardial_fiber1.70977263
43MP0010678_abnormal_skin_adnexa1.68681273
44MP0001970_abnormal_pain_threshold1.62443143
45MP0002736_abnormal_nociception_after1.61715323
46MP0004742_abnormal_vestibular_system1.61513314
47MP0002557_abnormal_social/conspecific_i1.60349291
48MP0001765_abnormal_ion_homeostasis1.59727047
49MP0006276_abnormal_autonomic_nervous1.55862734
50MP0009780_abnormal_chondrocyte_physiolo1.55374697
51MP0002184_abnormal_innervation1.53972435
52MP0004185_abnormal_adipocyte_glucose1.49673460
53MP0002009_preneoplasia1.48085043
54MP0004043_abnormal_pH_regulation1.47531642
55MP0001485_abnormal_pinna_reflex1.46342543
56MP0002733_abnormal_thermal_nociception1.42254733
57MP0002796_impaired_skin_barrier1.41887656
58MP0004142_abnormal_muscle_tone1.35816215
59MP0001188_hyperpigmentation1.35206794
60MP0005076_abnormal_cell_differentiation1.32195019
61MP0005666_abnormal_adipose_tissue1.32080882
62MP0001502_abnormal_circadian_rhythm1.30519884
63MP0002909_abnormal_adrenal_gland1.28868437
64MP0002638_abnormal_pupillary_reflex1.28450065
65MP0002098_abnormal_vibrissa_morphology1.28028396
66MP0000749_muscle_degeneration1.26890654
67MP0004036_abnormal_muscle_relaxation1.25511767
68MP0001984_abnormal_olfaction1.23586633
69MP0004885_abnormal_endolymph1.22827553
70MP0002066_abnormal_motor_capabilities/c1.22079850
71MP0004484_altered_response_of1.19368944
72MP0000003_abnormal_adipose_tissue1.19039677
73MP0002229_neurodegeneration1.18866854
74MP0004085_abnormal_heartbeat1.18528551
75MP0003787_abnormal_imprinting1.18514702
76MP0000383_abnormal_hair_follicle1.17626626
77MP0004084_abnormal_cardiac_muscle1.17201837
78MP0002882_abnormal_neuron_morphology1.16972738
79MP0004811_abnormal_neuron_physiology1.16051833
80MP0002971_abnormal_brown_adipose1.15682210
81MP0001666_abnormal_nutrient_absorption1.13374477
82MP0003137_abnormal_impulse_conducting1.13317226
83MP0001348_abnormal_lacrimal_gland1.13006707
84MP0001849_ear_inflammation1.12837702
85MP0003045_fibrosis1.12622401
86MP0001986_abnormal_taste_sensitivity1.11153916
87MP0004782_abnormal_surfactant_physiolog1.11060149
88MP0005375_adipose_tissue_phenotype1.09862895
89MP0005058_abnormal_lysosome_morphology1.09424528
90MP0003633_abnormal_nervous_system1.08916750
91MP0000955_abnormal_spinal_cord1.07826782
92MP0000427_abnormal_hair_cycle1.07481354
93MP0001529_abnormal_vocalization1.05991981
94MP0003632_abnormal_nervous_system1.05378740
95MP0003183_abnormal_peptide_metabolism1.05218210
96MP0006072_abnormal_retinal_apoptosis1.02728811
97MP0000778_abnormal_nervous_system1.01922259
98MP0005253_abnormal_eye_physiology1.00131474
99MP0005620_abnormal_muscle_contractility1.00000804
100MP0005670_abnormal_white_adipose0.96980812
101MP0010386_abnormal_urinary_bladder0.96415786
102MP0004858_abnormal_nervous_system0.95926061
103MP0005083_abnormal_biliary_tract0.95785114
104MP0001963_abnormal_hearing_physiology0.94268287
105MP0004130_abnormal_muscle_cell0.94133795
106MP0001177_atelectasis0.90913741
107MP0006292_abnormal_olfactory_placode0.88989334
108MP0005535_abnormal_body_temperature0.88817885
109MP0003631_nervous_system_phenotype0.88191185
110MP0004233_abnormal_muscle_weight0.87701741
111MP0008872_abnormal_physiological_respon0.86855617
112MP0002970_abnormal_white_adipose0.86756811
113MP0003634_abnormal_glial_cell0.85742983
114MP0000013_abnormal_adipose_tissue0.84434858
115MP0008775_abnormal_heart_ventricle0.83972707
116MP0000678_abnormal_parathyroid_gland0.83965626
117MP0010352_gastrointestinal_tract_polyps0.83384548
118MP0000920_abnormal_myelination0.82953320
119MP0002752_abnormal_somatic_nervous0.82713442
120MP0001664_abnormal_digestion0.81343687
121MP0003690_abnormal_glial_cell0.80205482
122MP0005409_darkened_coat_color0.80198084
123MP0000467_abnormal_esophagus_morphology0.79850254
124MP0002069_abnormal_eating/drinking_beha0.79833211
125MP0008874_decreased_physiological_sensi0.79783040
126MP0010329_abnormal_lipoprotein_level0.79464127
127MP0002972_abnormal_cardiac_muscle0.78893498
128MP0005501_abnormal_skin_physiology0.78237751
129MP0003453_abnormal_keratinocyte_physiol0.77696356
130MP0002078_abnormal_glucose_homeostasis0.77414876
131MP0002106_abnormal_muscle_physiology0.77283191
132MP0000377_abnormal_hair_follicle0.77159261
133MP0003868_abnormal_feces_composition0.76353809
134MP0003123_paternal_imprinting0.76236707
135MP0001905_abnormal_dopamine_level0.75944630
136MP0005330_cardiomyopathy0.74786562
137MP0000566_synostosis0.74575286
138MP0002249_abnormal_larynx_morphology0.74437173
139MP0005171_absent_coat_pigmentation0.74377364
140MP0005448_abnormal_energy_balance0.72209503
141MP0002896_abnormal_bone_mineralization0.72207819
142MP0005365_abnormal_bile_salt0.69863719
143MP0002152_abnormal_brain_morphology0.69624230
144MP0000747_muscle_weakness0.69540839
145MP0000759_abnormal_skeletal_muscle0.69372922

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.24813467
2Myokymia (HP:0002411)4.72376720
3Febrile seizures (HP:0002373)4.59738952
4Focal seizures (HP:0007359)4.48654094
5Progressive cerebellar ataxia (HP:0002073)4.11924645
6Visual hallucinations (HP:0002367)3.85400867
7Epileptic encephalopathy (HP:0200134)3.82035780
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.81709653
9Absent/shortened dynein arms (HP:0200106)3.81709653
10Gaze-evoked nystagmus (HP:0000640)3.56936500
11Action tremor (HP:0002345)3.54215732
12Atonic seizures (HP:0010819)3.49640337
13Obstructive sleep apnea (HP:0002870)3.40429051
14Ventricular fibrillation (HP:0001663)3.28600706
15Bundle branch block (HP:0011710)3.27695760
16Broad-based gait (HP:0002136)3.26967309
17Prolonged QT interval (HP:0001657)3.25967075
18Exercise-induced myalgia (HP:0003738)3.16400241
19Distal upper limb amyotrophy (HP:0007149)3.14667278
20Upper limb amyotrophy (HP:0009129)3.14667278
21Hyperacusis (HP:0010780)3.13963308
22Unilateral renal agenesis (HP:0000122)3.12464931
23Dysdiadochokinesis (HP:0002075)3.03699456
24Absence seizures (HP:0002121)3.03678317
25Abnormal EKG (HP:0003115)3.02898666
26Parakeratosis (HP:0001036)3.02310565
27Generalized tonic-clonic seizures (HP:0002069)3.02298712
28Syncope (HP:0001279)2.96012287
29Poor eye contact (HP:0000817)2.94238528
30Congenital stationary night blindness (HP:0007642)2.94220578
31Hand muscle atrophy (HP:0009130)2.93802548
32Central scotoma (HP:0000603)2.93128228
33Atrial fibrillation (HP:0005110)2.89056525
34Sudden death (HP:0001699)2.88193950
35Dialeptic seizures (HP:0011146)2.84216742
36Dysmetria (HP:0001310)2.74917735
37Insomnia (HP:0100785)2.71245375
38Spastic gait (HP:0002064)2.71124488
39Primary atrial arrhythmia (HP:0001692)2.69322141
40Fetal akinesia sequence (HP:0001989)2.67182965
41Abnormal ciliary motility (HP:0012262)2.66172458
42Neurofibrillary tangles (HP:0002185)2.65057880
43Abnormal social behavior (HP:0012433)2.59927814
44Impaired social interactions (HP:0000735)2.59927814
45Muscle hypertrophy of the lower extremities (HP:0008968)2.57366880
46Abnormality of dental color (HP:0011073)2.57053388
47Macroorchidism (HP:0000053)2.56461042
48Truncal ataxia (HP:0002078)2.55466021
49Pili torti (HP:0003777)2.54298297
50Ankle clonus (HP:0011448)2.53767310
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53203938
52Supraventricular tachycardia (HP:0004755)2.52996219
53Postural instability (HP:0002172)2.52831105
54Cerebral inclusion bodies (HP:0100314)2.48828686
55Anxiety (HP:0000739)2.48196478
56Dyschromatopsia (HP:0007641)2.46685233
57Calf muscle hypertrophy (HP:0008981)2.44741870
58Urinary bladder sphincter dysfunction (HP:0002839)2.43761701
59Dysmetric saccades (HP:0000641)2.43269949
60Metabolic alkalosis (HP:0200114)2.42381480
61Right ventricular cardiomyopathy (HP:0011663)2.42257448
62Absent eyebrow (HP:0002223)2.42244063
63Supraventricular arrhythmia (HP:0005115)2.42113962
64Abolished electroretinogram (ERG) (HP:0000550)2.41387003
65Spastic tetraparesis (HP:0001285)2.39181382
66Genetic anticipation (HP:0003743)2.38849285
67Ankyloglossia (HP:0010296)2.38014145
68Clonus (HP:0002169)2.36904975
69Decreased central vision (HP:0007663)2.35265734
70Abnormal eating behavior (HP:0100738)2.35235700
71Hyperphosphatemia (HP:0002905)2.29155400
72Germ cell neoplasia (HP:0100728)2.27239491
73Abnormality of nail color (HP:0100643)2.26447045
74Impaired vibration sensation in the lower limbs (HP:0002166)2.25940306
75Abnormal respiratory epithelium morphology (HP:0012253)2.24190979
76Abnormal respiratory motile cilium morphology (HP:0005938)2.24190979
77Intention tremor (HP:0002080)2.23352506
78Neuronal loss in central nervous system (HP:0002529)2.22611614
79Thin bony cortex (HP:0002753)2.22219968
80Heart block (HP:0012722)2.21754837
81Impaired smooth pursuit (HP:0007772)2.19330430
82Follicular hyperkeratosis (HP:0007502)2.19004179
83Abnormal respiratory motile cilium physiology (HP:0012261)2.18695742
84Bradycardia (HP:0001662)2.16722707
85Abnormality of the fingertips (HP:0001211)2.16148805
86Broad face (HP:0000283)2.15169597
87Abnormal hair laboratory examination (HP:0003328)2.14852230
88Scanning speech (HP:0002168)2.13786894
89Depression (HP:0000716)2.13420613
90Tetraplegia (HP:0002445)2.13026960
91Akinesia (HP:0002304)2.11040568
92Alopecia of scalp (HP:0002293)2.09518778
93Supranuclear gaze palsy (HP:0000605)2.08736031
94Abnormality of the calf musculature (HP:0001430)2.05363830
95Bowel incontinence (HP:0002607)2.04370518
96Abnormality of the periventricular white matter (HP:0002518)2.02794481
97Ventricular arrhythmia (HP:0004308)2.02003456
98Hemiparesis (HP:0001269)2.01976634
99Bronchomalacia (HP:0002780)2.00549166
100Abnormality of binocular vision (HP:0011514)2.00366448
101Diplopia (HP:0000651)2.00366448
102Abnormality of ocular smooth pursuit (HP:0000617)2.00281319
103Stridor (HP:0010307)1.98711545
104Myopathic facies (HP:0002058)1.98684703
105Abnormality of macular pigmentation (HP:0008002)1.98423538
106Abnormal atrioventricular conduction (HP:0005150)1.97797502
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97552160
108Impaired vibratory sensation (HP:0002495)1.97268708
109Milia (HP:0001056)1.96818870
110Myotonia (HP:0002486)1.96029120
111Hemiplegia (HP:0002301)1.95895910
112Cerebral aneurysm (HP:0004944)1.95816300
113Lower limb muscle weakness (HP:0007340)1.95289930
114Status epilepticus (HP:0002133)1.94191895
115Generalized hypopigmentation of hair (HP:0011358)1.93105416
116Difficulty running (HP:0009046)1.92926115
117Scotoma (HP:0000575)1.92652636
118Insidious onset (HP:0003587)1.92169336
119Termporal pattern (HP:0011008)1.92169336
120Distal lower limb amyotrophy (HP:0008944)1.92078426
121Epileptiform EEG discharges (HP:0011182)1.91568722
122Absent speech (HP:0001344)1.91140318
123Bilateral sensorineural hearing impairment (HP:0008619)1.90457943
124Heterotopia (HP:0002282)1.90156328
125Advanced eruption of teeth (HP:0006288)1.88657144
126Abnormality of calcium-phosphate metabolism (HP:0100530)1.88518228
127Abnormality of chloride homeostasis (HP:0011422)1.85413707
128Flat acetabular roof (HP:0003180)1.85270625
129Annular pancreas (HP:0001734)1.85052372
130Limb ataxia (HP:0002070)1.84567453
131Abnormality of saccadic eye movements (HP:0000570)1.84094798
132Nonprogressive disorder (HP:0003680)1.83662246
133Bony spicule pigmentary retinopathy (HP:0007737)1.83635427
134Increased circulating renin level (HP:0000848)1.81949296
135Hyperventilation (HP:0002883)1.81465958
136Hyperthyroidism (HP:0000836)1.81271016
137Decreased circulating renin level (HP:0003351)1.80960363
138Progressive inability to walk (HP:0002505)1.79550154
139EEG with generalized epileptiform discharges (HP:0011198)1.79114379
140Papilledema (HP:0001085)1.78936985
141Urinary urgency (HP:0000012)1.78694944
142Exercise-induced muscle cramps (HP:0003710)1.78399859
143Hamartoma of the eye (HP:0010568)1.78320443
144Abnormal large intestine physiology (HP:0012700)1.77909324
145Muscle fiber splitting (HP:0003555)1.77796124
146Abnormality of renin-angiotensin system (HP:0000847)1.77768499
147Lower limb amyotrophy (HP:0007210)1.77367169
148Hyperaldosteronism (HP:0000859)1.77061088
149J-shaped sella turcica (HP:0002680)1.75863471
150Abnormality of the corticospinal tract (HP:0002492)1.75579125
151Tetany (HP:0001281)1.75319624
152Renovascular hypertension (HP:0100817)1.74852236
153Mutism (HP:0002300)1.74645450
154Hyperkalemia (HP:0002153)1.74629189
155Hyperactive renin-angiotensin system (HP:0000841)1.74361531
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.73643816
157Hammertoe (HP:0001765)1.73002411
158Onion bulb formation (HP:0003383)1.72866088
159Pheochromocytoma (HP:0002666)1.72114136
160Sandal gap (HP:0001852)1.70703203
161Rigidity (HP:0002063)1.69157041
162Elfin facies (HP:0004428)1.68272622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14224203
2EEF2K3.96316844
3TRIB33.89009830
4EPHA43.35983410
5MST1R3.30088597
6SIK33.06140730
7TNIK2.94454852
8SIK22.77035953
9PINK12.69659306
10MAP3K42.68994655
11CDK122.49488820
12MAP2K72.43536527
13ICK2.42769778
14STK382.35568661
15MARK12.09880222
16MAP3K91.87586691
17PAK61.86671328
18MAP2K41.85988770
19PRKD31.83384645
20PHKG11.71498649
21PHKG21.71498649
22MINK11.69963020
23DAPK21.68356231
24LMTK21.66329848
25WNK11.62773339
26NTRK21.59141475
27EPHA21.55928517
28PKN21.48871399
29PRPF4B1.46619869
30CAMK11.44460667
31MAPK131.40360811
32MAPKAPK31.35088711
33MAP3K121.29708105
34RIPK41.29416598
35CAMKK11.29382537
36SGK4941.28641101
37SGK2231.28641101
38MET1.28078651
39CASK1.25574313
40CAMKK21.25472475
41SIK11.25320413
42SGK21.24578696
43IRAK21.24211392
44NEK61.22917895
45CDK51.18233964
46TRPM71.16794419
47MARK21.16624190
48OBSCN1.13930206
49OXSR11.12559066
50MAP2K61.09490425
51FES1.05836034
52GRK51.05154906
53MAPK111.04831334
54SGK31.00011873
55IRAK30.99260103
56CDC42BPA0.98472953
57SMG10.98430488
58PNCK0.97099809
59MUSK0.96504651
60FRK0.96074206
61MTOR0.95484129
62INSRR0.94597761
63CAMK2A0.94074779
64SCYL20.91047938
65SGK10.89326371
66CAMK2D0.89045761
67PRKCG0.88362835
68RET0.88326228
69PRKCH0.87450013
70BRD40.87073981
71CAMK1G0.86874119
72PDK40.85529592
73PDK30.85529592
74NTRK10.83490973
75MAPK120.80000162
76STK110.79114631
77NME10.78174374
78STK390.76563153
79CAMK40.76561294
80TNK20.75427096
81CDK30.72721183
82TYRO30.72232196
83CAMK2B0.71939893
84DMPK0.71467693
85FER0.71011350
86MAPKAPK50.69875057
87RPS6KB20.69485294
88MAPK100.68729362
89FGFR30.68039403
90BMPR20.67770501
91MAP3K60.67646973
92GRK10.67297689
93MARK30.65932510
94MAP3K10.65447124
95PLK20.65372543
96UHMK10.64682590
97WNK40.63694751
98CAMK2G0.63158689
99PRKAA10.62604278
100MAP2K10.61847586
101RIPK10.60246437
102PKN10.59087318
103FGFR40.58961339
104MAP3K70.57763345
105GRK70.56873156
106PDK20.56373915
107ALK0.55829087
108PRKCE0.55528151
109STK38L0.55239603
110RPS6KA20.54954674
111MAP3K130.54686128
112PDK10.53856452
113PDGFRA0.53819458
114CDK190.53247199
115PDPK10.52944047
116RPS6KA30.52425268
117ERBB20.51869468
118WNK30.51514740
119AKT30.50439026
120DYRK1A0.50250319
121ERN10.47836691
122RPS6KB10.47779617
123ZAK0.46826643
124PRKAA20.46124292
125DAPK10.45777748
126KSR20.45319172
127PRKACA0.44507369
128NEK10.43662126
129MAP3K20.43191103
130LATS20.43002383
131PRKD20.42536969
132PRKG10.42530581
133JAK10.42151140
134MAP2K20.41617719
135CAMK1D0.40000895
136MAPK80.39685529
137BMX0.37867529
138GSK3B0.37703702

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78503434
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99097501
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71705941
4Circadian entrainment_Homo sapiens_hsa047132.71089543
5Olfactory transduction_Homo sapiens_hsa047402.67652319
6GABAergic synapse_Homo sapiens_hsa047272.64982258
7Morphine addiction_Homo sapiens_hsa050322.62509116
8Glutamatergic synapse_Homo sapiens_hsa047242.61267843
9Phototransduction_Homo sapiens_hsa047442.58067360
10Long-term potentiation_Homo sapiens_hsa047202.22347470
11Salivary secretion_Homo sapiens_hsa049702.20374796
12Insulin secretion_Homo sapiens_hsa049112.14950032
13Taste transduction_Homo sapiens_hsa047422.08336423
14Amphetamine addiction_Homo sapiens_hsa050312.02202294
15Calcium signaling pathway_Homo sapiens_hsa040202.02010542
16Gastric acid secretion_Homo sapiens_hsa049711.97678587
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.91403461
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86457156
19Cholinergic synapse_Homo sapiens_hsa047251.86384647
20Dopaminergic synapse_Homo sapiens_hsa047281.82153231
21Cardiac muscle contraction_Homo sapiens_hsa042601.77953934
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74713845
23Serotonergic synapse_Homo sapiens_hsa047261.74214969
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73429020
25Renin secretion_Homo sapiens_hsa049241.70185985
26Oxytocin signaling pathway_Homo sapiens_hsa049211.61362625
27Type II diabetes mellitus_Homo sapiens_hsa049301.60391421
28Long-term depression_Homo sapiens_hsa047301.59367593
29Arginine biosynthesis_Homo sapiens_hsa002201.50773156
30Dilated cardiomyopathy_Homo sapiens_hsa054141.42375014
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37449002
32cAMP signaling pathway_Homo sapiens_hsa040241.36705967
33* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34235346
34Cocaine addiction_Homo sapiens_hsa050301.31731272
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29488644
36GnRH signaling pathway_Homo sapiens_hsa049121.28339842
37ABC transporters_Homo sapiens_hsa020101.23453636
38Bile secretion_Homo sapiens_hsa049761.23276466
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21318263
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19097410
41Pancreatic secretion_Homo sapiens_hsa049721.17386300
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16785578
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16178828
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10432042
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10284674
46Collecting duct acid secretion_Homo sapiens_hsa049661.09699843
47Other glycan degradation_Homo sapiens_hsa005111.09304246
48mTOR signaling pathway_Homo sapiens_hsa041501.08849071
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08681206
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07703559
51Circadian rhythm_Homo sapiens_hsa047101.03873044
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.00424247
53Mineral absorption_Homo sapiens_hsa049780.97853081
54Fructose and mannose metabolism_Homo sapiens_hsa000510.96126874
55Gap junction_Homo sapiens_hsa045400.93474019
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92046362
57Insulin resistance_Homo sapiens_hsa049310.91003191
58Vitamin B6 metabolism_Homo sapiens_hsa007500.88935452
59Lysine degradation_Homo sapiens_hsa003100.88881342
60Histidine metabolism_Homo sapiens_hsa003400.87606612
61Axon guidance_Homo sapiens_hsa043600.86974369
62Inositol phosphate metabolism_Homo sapiens_hsa005620.84763615
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81889368
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79821471
65Arginine and proline metabolism_Homo sapiens_hsa003300.79755029
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78828141
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.77882955
68Non-small cell lung cancer_Homo sapiens_hsa052230.75566894
69Estrogen signaling pathway_Homo sapiens_hsa049150.73660339
70ErbB signaling pathway_Homo sapiens_hsa040120.71746370
71Thyroid hormone synthesis_Homo sapiens_hsa049180.71680429
72Glucagon signaling pathway_Homo sapiens_hsa049220.70678822
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.69503580
74Melanogenesis_Homo sapiens_hsa049160.69248358
75Alzheimers disease_Homo sapiens_hsa050100.67069198
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66421649
77Fatty acid biosynthesis_Homo sapiens_hsa000610.65417761
78Ovarian steroidogenesis_Homo sapiens_hsa049130.65392891
79Choline metabolism in cancer_Homo sapiens_hsa052310.64121617
80MAPK signaling pathway_Homo sapiens_hsa040100.63970398
81Fatty acid metabolism_Homo sapiens_hsa012120.63052564
82Chronic myeloid leukemia_Homo sapiens_hsa052200.62582213
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.61788610
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60643651
85Dorso-ventral axis formation_Homo sapiens_hsa043200.58567827
86PPAR signaling pathway_Homo sapiens_hsa033200.58085360
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57718487
88Endometrial cancer_Homo sapiens_hsa052130.57571711
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55979698
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55636375
91Ras signaling pathway_Homo sapiens_hsa040140.54156372
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53862263
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51595017
94Glioma_Homo sapiens_hsa052140.51442297
95Oocyte meiosis_Homo sapiens_hsa041140.50941262
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50923156
97Prolactin signaling pathway_Homo sapiens_hsa049170.50222768
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49853944
99Oxidative phosphorylation_Homo sapiens_hsa001900.49298689
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49170391
101Vitamin digestion and absorption_Homo sapiens_hsa049770.47310516
102Phenylalanine metabolism_Homo sapiens_hsa003600.46665328
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45459093
104Acute myeloid leukemia_Homo sapiens_hsa052210.45363885
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44770130
106Butanoate metabolism_Homo sapiens_hsa006500.44598673
107Glycerolipid metabolism_Homo sapiens_hsa005610.43875398
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.43336310
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43104219
110Parkinsons disease_Homo sapiens_hsa050120.42135165
111Rap1 signaling pathway_Homo sapiens_hsa040150.40060300
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39813858
113Vibrio cholerae infection_Homo sapiens_hsa051100.38991472
114Insulin signaling pathway_Homo sapiens_hsa049100.37886348
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36454234
116Sphingolipid metabolism_Homo sapiens_hsa006000.36098329
117Huntingtons disease_Homo sapiens_hsa050160.36059250
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31397961
119Ether lipid metabolism_Homo sapiens_hsa005650.28506953
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28060068
121Wnt signaling pathway_Homo sapiens_hsa043100.27290122
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26841943
123Endocytosis_Homo sapiens_hsa041440.25937530
124Type I diabetes mellitus_Homo sapiens_hsa049400.25446333
125Renal cell carcinoma_Homo sapiens_hsa052110.24810169
126AMPK signaling pathway_Homo sapiens_hsa041520.24311799
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.23718610
128Tight junction_Homo sapiens_hsa045300.22849606
129VEGF signaling pathway_Homo sapiens_hsa043700.22400435
130African trypanosomiasis_Homo sapiens_hsa051430.22112874

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