PPIP5K2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.53352485
2nuclear pore organization (GO:0006999)5.08670671
3response to pheromone (GO:0019236)4.95698028
4neural tube formation (GO:0001841)4.74009574
5mitotic sister chromatid cohesion (GO:0007064)4.67816558
6mitotic chromosome condensation (GO:0007076)4.36472283
7protein localization to kinetochore (GO:0034501)4.13975267
8DNA double-strand break processing (GO:0000729)4.13553345
9protein prenylation (GO:0018342)4.08477003
10prenylation (GO:0097354)4.08477003
11regulation of pigment cell differentiation (GO:0050932)3.98897568
12pore complex assembly (GO:0046931)3.96988395
13monoubiquitinated protein deubiquitination (GO:0035520)3.82853416
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.78539805
15regulation of RNA export from nucleus (GO:0046831)3.74215803
16negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.73990650
17folic acid-containing compound biosynthetic process (GO:0009396)3.70205963
18regulation of histone H3-K9 methylation (GO:0051570)3.62189458
19pyrimidine nucleobase catabolic process (GO:0006208)3.61748806
20DNA unwinding involved in DNA replication (GO:0006268)3.61046340
21fucose catabolic process (GO:0019317)3.53310358
22L-fucose metabolic process (GO:0042354)3.53310358
23L-fucose catabolic process (GO:0042355)3.53310358
24positive regulation of developmental pigmentation (GO:0048087)3.52177573
25protein K11-linked deubiquitination (GO:0035871)3.48167270
26sister chromatid segregation (GO:0000819)3.47898302
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.46838775
28mitotic metaphase plate congression (GO:0007080)3.46109767
29negative regulation of fatty acid biosynthetic process (GO:0045717)3.45897122
30negative regulation of histone methylation (GO:0031061)3.43812252
31kinetochore organization (GO:0051383)3.42331593
32protein localization to chromosome, centromeric region (GO:0071459)3.41107110
33establishment of protein localization to Golgi (GO:0072600)3.34269934
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31873253
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31873253
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.31873253
37cardiac myofibril assembly (GO:0055003)3.29978612
38metaphase plate congression (GO:0051310)3.29789156
39attachment of spindle microtubules to kinetochore (GO:0008608)3.28894692
40regulation of spindle organization (GO:0090224)3.25957475
41regulation of sister chromatid cohesion (GO:0007063)3.23524650
42photoreceptor cell maintenance (GO:0045494)3.21836214
43centriole replication (GO:0007099)3.19296061
44mitotic nuclear envelope disassembly (GO:0007077)3.19148771
45replication fork processing (GO:0031297)3.18846005
46microtubule anchoring (GO:0034453)3.17991932
47sarcomere organization (GO:0045214)3.15646621
48establishment of chromosome localization (GO:0051303)3.14937501
49retinal cone cell development (GO:0046549)3.13061541
50regulation of DNA endoreduplication (GO:0032875)3.12663867
51negative regulation of potassium ion transmembrane transport (GO:1901380)3.11843162
52DNA duplex unwinding (GO:0032508)3.08549650
53meiotic chromosome segregation (GO:0045132)3.08373684
54dosage compensation (GO:0007549)3.08109629
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08000694
56negative regulation of mast cell activation (GO:0033004)3.07567252
57DNA geometric change (GO:0032392)3.07300100
58purine nucleobase biosynthetic process (GO:0009113)3.06687050
59IMP biosynthetic process (GO:0006188)3.04316514
60bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03916450
61cardiac muscle cell development (GO:0055013)3.03855678
62tricarboxylic acid cycle (GO:0006099)3.03476053
63regulation of meiosis I (GO:0060631)3.01987446
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01929925
65membrane disassembly (GO:0030397)3.01300427
66nuclear envelope disassembly (GO:0051081)3.01300427
67pre-miRNA processing (GO:0031054)2.99269877
68cilium morphogenesis (GO:0060271)2.98554690
69interkinetic nuclear migration (GO:0022027)2.96919270
70gamma-aminobutyric acid transport (GO:0015812)2.95914445
71cellular ketone body metabolic process (GO:0046950)2.95634509
72nucleobase biosynthetic process (GO:0046112)2.95042737
73rRNA catabolic process (GO:0016075)2.93576855
74piRNA metabolic process (GO:0034587)2.93452981
75nucleobase catabolic process (GO:0046113)2.92238097
76histone mRNA catabolic process (GO:0071044)2.92055358
77reflex (GO:0060004)2.91865152
78urea cycle (GO:0000050)2.89364800
79urea metabolic process (GO:0019627)2.89364800
80positive regulation of chromosome segregation (GO:0051984)2.88592048
81mitotic sister chromatid segregation (GO:0000070)2.87825078
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87790285
83lysine metabolic process (GO:0006553)2.87270044
84lysine catabolic process (GO:0006554)2.87270044
85regulation of nucleobase-containing compound transport (GO:0032239)2.86360915
86tetrahydrofolate metabolic process (GO:0046653)2.84575551
87protein targeting to Golgi (GO:0000042)2.83632345
88regulation of mitotic spindle organization (GO:0060236)2.82602076
89signal peptide processing (GO:0006465)2.82319227
90resolution of meiotic recombination intermediates (GO:0000712)2.80970145
91IMP metabolic process (GO:0046040)2.80318994
92kynurenine metabolic process (GO:0070189)2.79338055
93cardiac cell development (GO:0055006)2.78681161
94behavioral response to ethanol (GO:0048149)2.77482229
95epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76956401
96retrograde transport, vesicle recycling within Golgi (GO:0000301)2.75364492
97regulation of sarcomere organization (GO:0060297)2.75203963
98detection of light stimulus involved in sensory perception (GO:0050962)2.74235297
99detection of light stimulus involved in visual perception (GO:0050908)2.74235297
1002-oxoglutarate metabolic process (GO:0006103)2.74181752
101indolalkylamine metabolic process (GO:0006586)2.73225719
102behavioral response to nicotine (GO:0035095)2.72670228
103cilium organization (GO:0044782)2.70756946
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.70546883
105regulation of translation, ncRNA-mediated (GO:0045974)2.70546883
106negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70546883
107preassembly of GPI anchor in ER membrane (GO:0016254)2.70526068
108regulation of centriole replication (GO:0046599)2.69801469
109recombinational repair (GO:0000725)2.69453080
110ketone body metabolic process (GO:1902224)2.69374372
111regulation of telomere maintenance (GO:0032204)2.68717447
112carnitine shuttle (GO:0006853)2.68641988
113double-strand break repair via homologous recombination (GO:0000724)2.68457510
114presynaptic membrane assembly (GO:0097105)2.67949214
115reciprocal meiotic recombination (GO:0007131)2.66894019
116reciprocal DNA recombination (GO:0035825)2.66894019
117regulation of helicase activity (GO:0051095)2.66639836
118regulation of mitotic spindle checkpoint (GO:1903504)2.65483216
119regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65483216
120histone-serine phosphorylation (GO:0035404)2.65451143
121gene silencing by RNA (GO:0031047)2.64790147
122DNA methylation involved in gamete generation (GO:0043046)2.63758761
123cytoplasmic mRNA processing body assembly (GO:0033962)2.63653260
124cilium assembly (GO:0042384)2.63488874
125DNA topological change (GO:0006265)2.63124531
126glucocorticoid receptor signaling pathway (GO:0042921)2.63058469
127protein localization to cilium (GO:0061512)2.62123190
128regulation of MHC class II biosynthetic process (GO:0045346)2.62122703
129negative regulation of fatty acid metabolic process (GO:0045922)2.60243500
130chromosome condensation (GO:0030261)2.59813346
131DNA conformation change (GO:0071103)2.59492578
132phospholipid homeostasis (GO:0055091)2.59229468
133intestinal absorption (GO:0050892)2.58420397
134DNA integration (GO:0015074)2.58323712
135ribonucleoprotein complex disassembly (GO:0032988)2.58002721
136myofibril assembly (GO:0030239)2.57954023
137inner ear receptor stereocilium organization (GO:0060122)2.57629490
138negative regulation of DNA repair (GO:0045738)2.57487670
139fatty acid transmembrane transport (GO:1902001)2.57444633
140chromatin remodeling at centromere (GO:0031055)2.57388480
141protein localization to chromosome (GO:0034502)2.57090914
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.56788249
143cornea development in camera-type eye (GO:0061303)2.56718672
144negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56332144
145intraciliary transport (GO:0042073)2.53720293
146chromatin assembly (GO:0031497)2.53700879
147histone H2A monoubiquitination (GO:0035518)2.53650199
148DNA replication-independent nucleosome assembly (GO:0006336)2.53329668
149DNA replication-independent nucleosome organization (GO:0034724)2.53329668
150CENP-A containing nucleosome assembly (GO:0034080)2.53313826
151histone H2A acetylation (GO:0043968)2.53221660
152sister chromatid cohesion (GO:0007062)2.53070796
153regulation of triglyceride catabolic process (GO:0010896)2.52277858
154nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.52007500
155chromosome segregation (GO:0007059)2.51821102
156postreplication repair (GO:0006301)2.51805560
157nonmotile primary cilium assembly (GO:0035058)2.51636282
158forebrain morphogenesis (GO:0048853)2.51260035
159phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.50971534
160tachykinin receptor signaling pathway (GO:0007217)2.50746267
161indole-containing compound catabolic process (GO:0042436)2.50068285
162indolalkylamine catabolic process (GO:0046218)2.50068285
163tryptophan catabolic process (GO:0006569)2.50068285
164fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.50002536
165positive regulation of DNA-templated transcription, initiation (GO:2000144)2.49843691
166regulation of centrosome cycle (GO:0046605)2.49405878
167somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49322216
168somatic hypermutation of immunoglobulin genes (GO:0016446)2.49322216
169central nervous system neuron axonogenesis (GO:0021955)2.49131624
170spindle checkpoint (GO:0031577)2.48420121
171ether lipid metabolic process (GO:0046485)2.48297890
172maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47734888
173positive regulation of cell cycle checkpoint (GO:1901978)2.46673502
174synapsis (GO:0007129)2.46137808
175chromatin assembly or disassembly (GO:0006333)2.45886519
176histone exchange (GO:0043486)2.45243885
177microtubule organizing center organization (GO:0031023)2.44909968
178nitrogen cycle metabolic process (GO:0071941)2.44603769
179regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43744032
180DNA replication-dependent nucleosome organization (GO:0034723)2.43614581
181DNA replication-dependent nucleosome assembly (GO:0006335)2.43614581
182mRNA stabilization (GO:0048255)2.43582597
183RNA stabilization (GO:0043489)2.43582597
184embryonic epithelial tube formation (GO:0001838)2.43152760
185kinetochore assembly (GO:0051382)2.42396133
186histone H3-K9 methylation (GO:0051567)2.40499182
187axoneme assembly (GO:0035082)2.39306620
188cilium or flagellum-dependent cell motility (GO:0001539)2.38581823
189positive regulation of mRNA processing (GO:0050685)2.38333953
190L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.37591646
191definitive hemopoiesis (GO:0060216)2.36249653
192acrosome assembly (GO:0001675)2.35500924
193regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35368029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36716776
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.00355553
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90016796
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.33094643
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.32924466
6IGF1R_20145208_ChIP-Seq_DFB_Human3.28916836
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25466629
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17670147
9ZNF274_21170338_ChIP-Seq_K562_Hela3.08559415
10GBX2_23144817_ChIP-Seq_PC3_Human3.06851162
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.87406044
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.75853414
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72760148
14TAF15_26573619_Chip-Seq_HEK293_Human2.63524489
15FUS_26573619_Chip-Seq_HEK293_Human2.58387792
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53639390
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52384267
18AR_21909140_ChIP-Seq_LNCAP_Human2.50204090
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49075582
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.47989570
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.33012629
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.32019496
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28411345
24VDR_22108803_ChIP-Seq_LS180_Human2.28040219
25P300_19829295_ChIP-Seq_ESCs_Human2.27230942
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.20460058
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17802632
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12383649
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12292210
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.06607804
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03391063
32ER_23166858_ChIP-Seq_MCF-7_Human1.88835430
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87615847
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85813039
35* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80966903
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80467903
37* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77613488
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.77463494
39STAT3_23295773_ChIP-Seq_U87_Human1.75848018
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74127758
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73528598
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70938599
43CBP_20019798_ChIP-Seq_JUKART_Human1.70938599
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70748415
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69864403
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66649288
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.65360162
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64893136
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.63909756
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63570409
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62785765
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61814920
53GATA1_22025678_ChIP-Seq_K562_Human1.59728458
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.58774657
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58452085
56* EZH2_27294783_Chip-Seq_NPCs_Mouse1.57916133
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57883952
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57462874
59TCF4_23295773_ChIP-Seq_U87_Human1.56308294
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53997952
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.52731670
62* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52590729
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51810857
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49205853
65* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48229422
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48129404
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.47438940
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47058342
69* NANOG_18555785_Chip-Seq_ESCs_Mouse1.46341642
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44487579
71AR_25329375_ChIP-Seq_VCAP_Human1.43325669
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42291769
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40385406
74* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39721900
75* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39484839
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37897082
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37897082
78* NFE2_27457419_Chip-Seq_LIVER_Mouse1.37880446
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37483612
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37440765
81ELK1_19687146_ChIP-ChIP_HELA_Human1.36901572
82* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35902880
83BCAT_22108803_ChIP-Seq_LS180_Human1.35466136
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35124379
85KDM5A_27292631_Chip-Seq_BREAST_Human1.34947588
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.31917677
87* P53_22387025_ChIP-Seq_ESCs_Mouse1.29154943
88GATA4_21415370_ChIP-Seq_HL-1_Mouse1.28600741
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27914241
90* E2F1_18555785_Chip-Seq_ESCs_Mouse1.26870855
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26806455
92MYC_22102868_ChIP-Seq_BL_Human1.25881916
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25810693
94TCF4_22108803_ChIP-Seq_LS180_Human1.25611577
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.25025774
96CIITA_25753668_ChIP-Seq_RAJI_Human1.24617266
97RUNX2_22187159_ChIP-Seq_PCA_Human1.24071426
98* CRX_20693478_ChIP-Seq_RETINA_Mouse1.23771428
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22382686
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22007501
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21965711
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21601079
103* SOX2_19829295_ChIP-Seq_ESCs_Human1.20558078
104* NANOG_19829295_ChIP-Seq_ESCs_Human1.20558078
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19846060
106* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19783302
107ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19450649
108AR_21572438_ChIP-Seq_LNCaP_Human1.18090631
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16724913
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16531076
111TP53_22573176_ChIP-Seq_HFKS_Human1.16333179
112* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15516758
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14616884
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14311177
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14301708
116IRF1_19129219_ChIP-ChIP_H3396_Human1.14287376
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.13569094
118RNF2_27304074_Chip-Seq_NSC_Mouse1.13568267
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.13458877
120* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13103868
121IRF8_22096565_ChIP-ChIP_GC-B_Human1.12852883
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12521546
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12484046
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12184829
125MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11562252
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11497468
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.11268759
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11250689
129* P300_18555785_Chip-Seq_ESCs_Mouse1.11080885
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10199659
131* STAT3_18555785_Chip-Seq_ESCs_Mouse1.08911070
132* FOXP3_21729870_ChIP-Seq_TREG_Human1.08590551
133* CDX2_22108803_ChIP-Seq_LS180_Human1.08144874
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07386495
135ZNF263_19887448_ChIP-Seq_K562_Human1.07212341
136JUN_21703547_ChIP-Seq_K562_Human1.07040274
137* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06700140
138* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06585960
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05771071
140VDR_23849224_ChIP-Seq_CD4+_Human1.03131181
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.02670299
142EZH2_22144423_ChIP-Seq_EOC_Human1.02467513
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01628127
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01618327
145SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01320483
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00855396
147FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00852523
148CLOCK_20551151_ChIP-Seq_293T_Human1.00701923
149MYC_18940864_ChIP-ChIP_HL60_Human1.00580970
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99953126
151* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97633994
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.96948551
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94870341
154ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94105102
155GATA6_25053715_ChIP-Seq_YYC3_Human0.91646659
156MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91368316
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89922995
158TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87573450
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86475077
160EWS_26573619_Chip-Seq_HEK293_Human0.86384618
161* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86231354
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85745599
163CHD1_26751641_Chip-Seq_LNCaP_Human0.85724479
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82872211
165E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82803263
166SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82215537
167KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81587869
168EP300_21415370_ChIP-Seq_HL-1_Mouse0.80870405
169FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80092141
170MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78276848
171MYB_26560356_Chip-Seq_TH1_Human0.76824181
172GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76416898
173NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76305501
174HNF4A_19822575_ChIP-Seq_HepG2_Human0.75377266
175MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75343651
176BRD4_25478319_ChIP-Seq_HGPS_Human0.75204515
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75194441
178TFEB_21752829_ChIP-Seq_HELA_Human0.74960841
179MYC_18358816_ChIP-ChIP_MESCs_Mouse0.74457989
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74138115
181SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73965100
182FOXA2_19822575_ChIP-Seq_HepG2_Human0.73404217
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.72551830
184XRN2_22483619_ChIP-Seq_HELA_Human0.72188250
185BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72143972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.35277127
2MP0005360_urolithiasis3.22608213
3MP0002139_abnormal_hepatobiliary_system3.09538318
4MP0004084_abnormal_cardiac_muscle3.01738002
5MP0005085_abnormal_gallbladder_physiolo2.79557239
6MP0010094_abnormal_chromosome_stability2.67922643
7MP0002102_abnormal_ear_morphology2.55581400
8MP0000569_abnormal_digit_pigmentation2.53337412
9MP0004147_increased_porphyrin_level2.52323509
10MP0005365_abnormal_bile_salt2.49550490
11MP0002837_dystrophic_cardiac_calcinosis2.49139682
12MP0003693_abnormal_embryo_hatching2.48544226
13MP0003806_abnormal_nucleotide_metabolis2.39899986
14MP0006072_abnormal_retinal_apoptosis2.36492339
15MP0003077_abnormal_cell_cycle2.32588147
16MP0003111_abnormal_nucleus_morphology2.30961288
17MP0010352_gastrointestinal_tract_polyps2.22475254
18MP0004215_abnormal_myocardial_fiber2.17564578
19MP0003567_abnormal_fetal_cardiomyocyte2.14845917
20MP0003252_abnormal_bile_duct2.11899421
21MP0004957_abnormal_blastocyst_morpholog2.08622860
22MP0000427_abnormal_hair_cycle2.04785731
23MP0003195_calcinosis2.04758541
24MP0010307_abnormal_tumor_latency2.01820618
25MP0001188_hyperpigmentation1.97804972
26MP0005551_abnormal_eye_electrophysiolog1.97684246
27MP0005253_abnormal_eye_physiology1.96784132
28MP0009697_abnormal_copulation1.75346327
29MP0003880_abnormal_central_pattern1.75073737
30MP0005174_abnormal_tail_pigmentation1.74265581
31MP0004043_abnormal_pH_regulation1.71208911
32MP0003984_embryonic_growth_retardation1.69068212
33MP0010630_abnormal_cardiac_muscle1.68866056
34MP0005380_embryogenesis_phenotype1.68663343
35MP0001672_abnormal_embryogenesis/_devel1.68663343
36MP0006292_abnormal_olfactory_placode1.68557039
37MP0009046_muscle_twitch1.68291975
38MP0001730_embryonic_growth_arrest1.67959608
39MP0002088_abnormal_embryonic_growth/wei1.67599044
40MP0006276_abnormal_autonomic_nervous1.66067568
41MP0001984_abnormal_olfaction1.64932041
42MP0003123_paternal_imprinting1.63399022
43MP0003221_abnormal_cardiomyocyte_apopto1.61624865
44MP0005646_abnormal_pituitary_gland1.61059257
45MP0005330_cardiomyopathy1.59041425
46MP0002396_abnormal_hematopoietic_system1.58921207
47MP0005075_abnormal_melanosome_morpholog1.58592329
48MP0002009_preneoplasia1.57654287
49MP0003705_abnormal_hypodermis_morpholog1.54954740
50MP0003646_muscle_fatigue1.53430431
51MP0005171_absent_coat_pigmentation1.52464791
52MP0002095_abnormal_skin_pigmentation1.52412022
53MP0000631_abnormal_neuroendocrine_gland1.52051845
54MP0003121_genomic_imprinting1.51490636
55MP0001529_abnormal_vocalization1.50570071
56MP0000383_abnormal_hair_follicle1.48765793
57MP0008058_abnormal_DNA_repair1.48655126
58MP0000015_abnormal_ear_pigmentation1.47251059
59MP0004036_abnormal_muscle_relaxation1.44614210
60MP0003890_abnormal_embryonic-extraembry1.44423266
61MP0004264_abnormal_extraembryonic_tissu1.43354457
62MP0008775_abnormal_heart_ventricle1.42282787
63MP0008007_abnormal_cellular_replicative1.41955832
64MP0004142_abnormal_muscle_tone1.41370899
65MP0005084_abnormal_gallbladder_morpholo1.39505869
66MP0004197_abnormal_fetal_growth/weight/1.39223543
67MP0002751_abnormal_autonomic_nervous1.36276884
68MP0001986_abnormal_taste_sensitivity1.35900713
69MP0002086_abnormal_extraembryonic_tissu1.32706347
70MP0005385_cardiovascular_system_phenoty1.31570695
71MP0001544_abnormal_cardiovascular_syste1.31570695
72MP0001697_abnormal_embryo_size1.30223021
73MP0009672_abnormal_birth_weight1.29745440
74MP0002972_abnormal_cardiac_muscle1.28896080
75MP0003300_gastrointestinal_ulcer1.27770428
76MP0000350_abnormal_cell_proliferation1.27622179
77MP0008877_abnormal_DNA_methylation1.26740213
78MP0002928_abnormal_bile_duct1.26568096
79MP0001968_abnormal_touch/_nociception1.25071860
80MP0005408_hypopigmentation1.24756659
81MP0001666_abnormal_nutrient_absorption1.23947551
82MP0000372_irregular_coat_pigmentation1.23349047
83MP0001486_abnormal_startle_reflex1.22297597
84MP0005645_abnormal_hypothalamus_physiol1.20602516
85MP0005220_abnormal_exocrine_pancreas1.20005025
86MP0000778_abnormal_nervous_system1.19322857
87MP0004087_abnormal_muscle_fiber1.18993466
88MP0005386_behavior/neurological_phenoty1.18648982
89MP0004924_abnormal_behavior1.18648982
90MP0002938_white_spotting1.17650327
91MP0009053_abnormal_anal_canal1.14728843
92MP0002272_abnormal_nervous_system1.13949582
93MP0008875_abnormal_xenobiotic_pharmacok1.13841318
94MP0008995_early_reproductive_senescence1.13686143
95MP0009745_abnormal_behavioral_response1.11884110
96MP0002084_abnormal_developmental_patter1.11481154
97MP0001501_abnormal_sleep_pattern1.10808329
98MP0006054_spinal_hemorrhage1.10032990
99MP0005076_abnormal_cell_differentiation1.08914586
100MP0002127_abnormal_cardiovascular_syste1.08729431
101MP0003828_pulmonary_edema1.07945803
102MP0005187_abnormal_penis_morphology1.07875915
103MP0003787_abnormal_imprinting1.06703927
104MP0010386_abnormal_urinary_bladder1.05976095
105MP0000537_abnormal_urethra_morphology1.05497675
106MP0000609_abnormal_liver_physiology1.05456805
107MP0001324_abnormal_eye_pigmentation1.05373783
108MP0002080_prenatal_lethality1.04133962
109MP0008872_abnormal_physiological_respon1.04129308
110MP0002085_abnormal_embryonic_tissue1.03733658
111MP0000266_abnormal_heart_morphology1.03492423
112MP0010329_abnormal_lipoprotein_level1.02775427
113MP0003137_abnormal_impulse_conducting1.01956096
114MP0004133_heterotaxia1.01870924
115MP0002735_abnormal_chemical_nociception1.01397715
116MP0002877_abnormal_melanocyte_morpholog0.99303942
117MP0010234_abnormal_vibrissa_follicle0.98821098
118MP0001764_abnormal_homeostasis0.98421242
119MP0005248_abnormal_Harderian_gland0.94976953
120MP0002638_abnormal_pupillary_reflex0.94850981
121MP0002184_abnormal_innervation0.94358532
122MP0009703_decreased_birth_body0.94348037
123MP0006138_congestive_heart_failure0.94179735
124MP0002736_abnormal_nociception_after0.94144581
125MP0000598_abnormal_liver_morphology0.92952551
126MP0003937_abnormal_limbs/digits/tail_de0.92753626
127MP0004808_abnormal_hematopoietic_stem0.91436389
128MP0000647_abnormal_sebaceous_gland0.91080795
129MP0001293_anophthalmia0.91008039
130MP0003656_abnormal_erythrocyte_physiolo0.90554995
131MP0003698_abnormal_male_reproductive0.90508175
132MP0008932_abnormal_embryonic_tissue0.87753381
133MP0002234_abnormal_pharynx_morphology0.87289242
134MP0004130_abnormal_muscle_cell0.87288383
135MP0001929_abnormal_gametogenesis0.86107438
136MP0005195_abnormal_posterior_eye0.86030502
137MP0001915_intracranial_hemorrhage0.85859120
138MP0002572_abnormal_emotion/affect_behav0.85510032
139MP0003122_maternal_imprinting0.85152660
140MP0010678_abnormal_skin_adnexa0.83637264
141MP0004510_myositis0.82573224
142MP0003786_premature_aging0.82140038
143MP0003635_abnormal_synaptic_transmissio0.79547725
144MP0002067_abnormal_sensory_capabilities0.79463236
145MP0003136_yellow_coat_color0.79310822
146MP0005391_vision/eye_phenotype0.79204718
147MP0002925_abnormal_cardiovascular_devel0.78377595
148MP0003045_fibrosis0.77478655
149MP0002128_abnormal_blood_circulation0.76192533
150MP0000490_abnormal_crypts_of0.76111742
151MP0003950_abnormal_plasma_membrane0.75780454
152MP0002557_abnormal_social/conspecific_i0.75758409
153MP0002269_muscular_atrophy0.75752349
154MP0000653_abnormal_sex_gland0.75129160
155MP0009840_abnormal_foam_cell0.74911343
156MP0002063_abnormal_learning/memory/cond0.74899545
157MP0000371_diluted_coat_color0.74351344
158MP0002166_altered_tumor_susceptibility0.72659118
159MP0005319_abnormal_enzyme/_coenzyme0.72262411
160MP0005389_reproductive_system_phenotype0.71974269
161MP0008789_abnormal_olfactory_epithelium0.71617122
162MP0005367_renal/urinary_system_phenotyp0.71452008
163MP0000516_abnormal_urinary_system0.71452008
164MP0004885_abnormal_endolymph0.71259398
165MP0005395_other_phenotype0.71033823
166MP0003943_abnormal_hepatobiliary_system0.70984538
167MP0002019_abnormal_tumor_incidence0.70982079
168MP0000313_abnormal_cell_death0.70704889
169MP0003566_abnormal_cell_adhesion0.70598644
170MP0002210_abnormal_sex_determination0.69595041
171MP0003763_abnormal_thymus_physiology0.68945584
172MP0002138_abnormal_hepatobiliary_system0.68088025
173MP0003868_abnormal_feces_composition0.67652412
174MP0003935_abnormal_craniofacial_develop0.66424885
175MP0004484_altered_response_of0.65657739
176MP0000751_myopathy0.65428173
177MP0005266_abnormal_metabolism0.65121475
178MP0003718_maternal_effect0.62699009

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.87809591
2Hypobetalipoproteinemia (HP:0003563)3.54207550
3Ventricular tachycardia (HP:0004756)3.53167320
4Intrahepatic cholestasis (HP:0001406)3.49599969
5Hypoglycemic coma (HP:0001325)3.48308185
6Hyperventilation (HP:0002883)3.42693015
7Pancreatic fibrosis (HP:0100732)3.38752707
8Right ventricular cardiomyopathy (HP:0011663)3.38663739
9Medial flaring of the eyebrow (HP:0010747)3.34332280
10Papillary thyroid carcinoma (HP:0002895)3.33385229
11Nephronophthisis (HP:0000090)3.26024202
12Abnormality of the renal cortex (HP:0011035)3.19214473
13True hermaphroditism (HP:0010459)3.17448004
14Sudden death (HP:0001699)3.15944110
15Molar tooth sign on MRI (HP:0002419)3.15595455
16Abnormality of midbrain morphology (HP:0002418)3.15595455
17Epidermoid cyst (HP:0200040)3.14704100
18Atrial fibrillation (HP:0005110)2.97982788
19Abnormality of the renal medulla (HP:0100957)2.97706155
20Attenuation of retinal blood vessels (HP:0007843)2.92969003
21Lipoatrophy (HP:0100578)2.89111423
22Gaze-evoked nystagmus (HP:0000640)2.81818298
23Hyperglycemia (HP:0003074)2.81051529
24Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76823881
25Protruding tongue (HP:0010808)2.76265241
26Gait imbalance (HP:0002141)2.75686189
27Abnormality of the fingertips (HP:0001211)2.74070273
28Pancreatic islet-cell hyperplasia (HP:0004510)2.71911574
29Congenital primary aphakia (HP:0007707)2.71904571
30Abnormality of lateral ventricle (HP:0030047)2.71474089
31Abolished electroretinogram (ERG) (HP:0000550)2.70816448
32Deep venous thrombosis (HP:0002625)2.70792573
33Tubulointerstitial nephritis (HP:0001970)2.70001780
34Subaortic stenosis (HP:0001682)2.66903309
35Abnormality of the left ventricular outflow tract (HP:0011103)2.66903309
36Hypochromic microcytic anemia (HP:0004840)2.66000824
37Primary atrial arrhythmia (HP:0001692)2.65131471
38Chronic hepatic failure (HP:0100626)2.63982286
39Fair hair (HP:0002286)2.63708468
40Chromsome breakage (HP:0040012)2.63222113
41Drooling (HP:0002307)2.58305108
42Genetic anticipation (HP:0003743)2.57916486
43Nephrogenic diabetes insipidus (HP:0009806)2.57878703
44Progressive inability to walk (HP:0002505)2.57826990
45Volvulus (HP:0002580)2.56649807
46Meningioma (HP:0002858)2.56027732
47Abnormality of pyrimidine metabolism (HP:0004353)2.54790850
48Supraventricular tachycardia (HP:0004755)2.51244465
49Subacute progressive viral hepatitis (HP:0006572)2.50569173
50Hypolipoproteinemia (HP:0010981)2.50502192
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.47874130
52Cortical dysplasia (HP:0002539)2.44359542
53Supraventricular arrhythmia (HP:0005115)2.44062386
54Absent speech (HP:0001344)2.42544079
55Dilated cardiomyopathy (HP:0001644)2.41096599
56Cutaneous melanoma (HP:0012056)2.40795032
57Short 4th metacarpal (HP:0010044)2.40374542
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.40374542
59Congenital stationary night blindness (HP:0007642)2.38636573
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.38063198
61Abnormality of methionine metabolism (HP:0010901)2.37581750
62Abnormality of the astrocytes (HP:0100707)2.35672727
63Astrocytoma (HP:0009592)2.35672727
64Stomach cancer (HP:0012126)2.34559554
65Palpitations (HP:0001962)2.33253025
66Febrile seizures (HP:0002373)2.33140670
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32534602
68Excessive salivation (HP:0003781)2.31884098
69Thyroiditis (HP:0100646)2.31446846
70Hyperammonemia (HP:0001987)2.30965229
71Inability to walk (HP:0002540)2.29638517
72Genital tract atresia (HP:0001827)2.29617956
73Medulloblastoma (HP:0002885)2.24237857
74Cystic liver disease (HP:0006706)2.23874462
75Macroorchidism (HP:0000053)2.22882370
76Biliary tract neoplasm (HP:0100574)2.21877911
77Broad-based gait (HP:0002136)2.21668926
78Methylmalonic acidemia (HP:0002912)2.20768882
79Neoplasm of the small intestine (HP:0100833)2.18404315
80Hypothermia (HP:0002045)2.18325661
81Lissencephaly (HP:0001339)2.17654636
82Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17625205
83Abnormal biliary tract morphology (HP:0012440)2.17623646
84Syncope (HP:0001279)2.17136469
85Acanthocytosis (HP:0001927)2.17101624
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16675525
87Widely spaced teeth (HP:0000687)2.16242062
88Abnormality of chromosome stability (HP:0003220)2.15793108
89Abnormality of the 4th metacarpal (HP:0010012)2.14962965
90Acute myeloid leukemia (HP:0004808)2.14563532
91Impulsivity (HP:0100710)2.13509387
92Vaginal atresia (HP:0000148)2.13281307
93Hypoglycemic seizures (HP:0002173)2.12958417
94Thyroid carcinoma (HP:0002890)2.11515626
95Ovarian neoplasm (HP:0100615)2.11478739
96Tubular atrophy (HP:0000092)2.10700031
97Small hand (HP:0200055)2.10348250
98Renal cortical cysts (HP:0000803)2.10037292
99Generalized hypopigmentation of hair (HP:0011358)2.09728002
100Constricted visual fields (HP:0001133)2.09697178
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.09515787
102Ependymoma (HP:0002888)2.09409812
103Hepatocellular carcinoma (HP:0001402)2.09323779
104Lymphangioma (HP:0100764)2.08419408
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.07810437
106Abnormality of the common coagulation pathway (HP:0010990)2.05398815
107Bony spicule pigmentary retinopathy (HP:0007737)2.04193905
108Abnormality of macular pigmentation (HP:0008002)2.04062000
109Neoplasm of the adrenal cortex (HP:0100641)2.01418799
110Neoplasm of the adrenal gland (HP:0100631)2.01051359
111Progressive cerebellar ataxia (HP:0002073)2.01042280
112Type II lissencephaly (HP:0007260)2.00280440
113Abnormality of the pancreatic islet cells (HP:0006476)2.00059235
114Abnormality of endocrine pancreas physiology (HP:0012093)2.00059235
115Uterine neoplasm (HP:0010784)1.99734735
116Short foot (HP:0001773)1.98798618
117Abnormality of chromosome segregation (HP:0002916)1.98313836
118Tubulointerstitial abnormality (HP:0001969)1.97092814
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96972621
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.96972621
121Colon cancer (HP:0003003)1.96772533
122Asymmetry of the thorax (HP:0001555)1.96423354
123Glioma (HP:0009733)1.96299458
124Hyperinsulinemic hypoglycemia (HP:0000825)1.94136148
125Hypoplastic iliac wings (HP:0002866)1.93648895
126Rhabdomyosarcoma (HP:0002859)1.92674576
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92491608
128Exercise-induced muscle cramps (HP:0003710)1.92027564
129Poor coordination (HP:0002370)1.92008348
130Postaxial foot polydactyly (HP:0001830)1.91844277
131Sloping forehead (HP:0000340)1.91744530
132Cerebellar dysplasia (HP:0007033)1.90448446
133Congenital hepatic fibrosis (HP:0002612)1.90125536
134Increased mean platelet volume (HP:0011877)1.89489308
135Abnormal rod and cone electroretinograms (HP:0008323)1.89397145
136Hepatoblastoma (HP:0002884)1.89288958
137Ectopic kidney (HP:0000086)1.88786136
138Acute lymphatic leukemia (HP:0006721)1.88485494
139Benign neoplasm of the central nervous system (HP:0100835)1.88060670
140Intestinal atresia (HP:0011100)1.87315925
141Cafe-au-lait spot (HP:0000957)1.86591668
142Neonatal death (HP:0003811)1.85703561
143Postaxial hand polydactyly (HP:0001162)1.83363751
144Rhabdomyolysis (HP:0003201)1.80876296
145Pachygyria (HP:0001302)1.80581389
146Abnormality of the corticospinal tract (HP:0002492)1.80553620
147Ketoacidosis (HP:0001993)1.80500108
148Spinal cord lesions (HP:0100561)1.80462181
149Syringomyelia (HP:0003396)1.80462181
150Neoplasm of the oral cavity (HP:0100649)1.80333854
151Dialeptic seizures (HP:0011146)1.80225088
152Amyotrophic lateral sclerosis (HP:0007354)1.80178504
153Increased nuchal translucency (HP:0010880)1.79796323
154Long eyelashes (HP:0000527)1.79750391
155Fat malabsorption (HP:0002630)1.79648818
156Hypoalphalipoproteinemia (HP:0003233)1.79481475
157Xanthomatosis (HP:0000991)1.78948698
158Bile duct proliferation (HP:0001408)1.78769795
159Abnormal biliary tract physiology (HP:0012439)1.78769795
160Astigmatism (HP:0000483)1.78467774
161Skin nodule (HP:0200036)1.78217505
162Thyroid-stimulating hormone excess (HP:0002925)1.78024348
163Rectal prolapse (HP:0002035)1.77291591
164Deviation of the thumb (HP:0009603)1.76768339
165Abnormality of fatty-acid metabolism (HP:0004359)1.76721104
166Focal motor seizures (HP:0011153)1.76294795
167Abnormal platelet volume (HP:0011876)1.75552389
168Patellar aplasia (HP:0006443)1.75546628
169Abnormality of the labia minora (HP:0012880)1.75463530
170Neoplasm of the rectum (HP:0100743)1.74520906
171Birth length less than 3rd percentile (HP:0003561)1.73080490
172Clubbing of toes (HP:0100760)1.73005898
173Ventricular arrhythmia (HP:0004308)1.71953589
174Deep philtrum (HP:0002002)1.71100382
175Myelodysplasia (HP:0002863)1.70740739
176Hamartoma of the eye (HP:0010568)1.70702153
177Focal seizures (HP:0007359)1.70615098
178Prominent nasal bridge (HP:0000426)1.70440266
179Abnormality of alanine metabolism (HP:0010916)1.70094743
180Hyperalaninemia (HP:0003348)1.70094743
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70094743
182Poikilocytosis (HP:0004447)1.69294485
183Abnormality of B cell number (HP:0010975)1.68781369
184Broad foot (HP:0001769)1.67080161
185Narrow forehead (HP:0000341)1.63897338
186Short tibia (HP:0005736)1.63251370
187Hip dysplasia (HP:0001385)1.63182482
188Pendular nystagmus (HP:0012043)1.62586059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.13949450
2LATS13.54571223
3PKN23.12214005
4CDC72.96991809
5BMPR1B2.69929548
6CDK122.64320494
7FRK2.62056612
8MAP3K42.54714927
9WNK32.49627460
10ACVR1B2.28820934
11NEK12.10094144
12AKT32.06724054
13TTN2.05220924
14CASK1.89637561
15MAP4K21.89275954
16ZAK1.86220445
17NEK21.79500658
18BCR1.76804929
19PINK11.76426641
20EEF2K1.74172685
21SRPK11.73595891
22MAPK131.69674346
23PDK31.68482177
24PDK41.68482177
25TTK1.67622124
26MARK11.66869185
27STK241.64818784
28STK41.63786827
29STK31.61808476
30MKNK11.55453243
31ADRBK21.50247433
32MAP2K71.47026788
33FLT31.46211207
34ATR1.43275810
35PLK41.41851985
36TRIM281.35235887
37BRD41.33352773
38PLK31.32533092
39ERBB41.32507843
40NEK91.31023622
41GRK11.30955824
42RPS6KB21.30051123
43NUAK11.29391288
44TEC1.23997643
45CDK41.23849432
46CSNK1G11.22798245
47STK38L1.22503662
48PLK21.22435101
49AURKB1.19181225
50CSNK1G21.19078926
51ATM1.18479965
52BUB11.17787708
53FGFR31.17179391
54PASK1.13653713
55INSRR1.13172466
56CSNK1G31.11438893
57MAP3K101.11184929
58STK101.10797296
59TNIK1.08595194
60FGFR21.08116151
61ERBB31.07144557
62CHEK11.04524777
63TRPM71.02540548
64OXSR11.02153538
65BRSK20.99447234
66MAP2K40.98158680
67CDK60.93885911
68CHEK20.92661025
69PNCK0.92057213
70TGFBR10.91957131
71TRIB30.91909775
72PLK10.90369814
73TAF10.89169821
74MAP3K140.88652263
75CDK190.88270677
76MELK0.87708303
77PRKAA10.86089904
78PRKCE0.85673877
79TSSK60.85241337
80KIT0.83422610
81PAK30.82908008
82FGFR40.81509169
83TAOK30.81455849
84MTOR0.80373636
85JAK30.80321653
86PTK60.79191980
87PIK3CG0.78967656
88WEE10.77773484
89CAMKK20.75793097
90MAP3K80.74650761
91EIF2AK10.74222465
92EPHA40.72349808
93DYRK20.72293772
94STK390.71603890
95DYRK30.71478248
96NTRK30.71385576
97CAMK1D0.71336907
98RPS6KB10.70311963
99DAPK20.70160689
100SGK20.68544217
101CDK20.68095923
102PIK3CA0.67079456
103CCNB10.65046602
104OBSCN0.63906492
105CDK10.63426844
106SGK30.63421891
107NLK0.63176535
108SCYL20.62184343
109VRK10.58988870
110CDK30.58851884
111ADRBK10.57865601
112ALK0.57429861
113RPS6KA40.57416885
114TXK0.57301079
115CHUK0.57296322
116PDK20.54945916
117FER0.54709573
118MAP3K60.54623066
119MKNK20.54404534
120JAK10.53322500
121FGFR10.51759737
122ITK0.51310249
123CDK70.50833670
124PRKG20.50596957
125PRKAA20.50085675
126MAP3K50.49779647
127TYK20.48993550
128MAPK110.46913820
129WNK40.46810093
130EPHA20.46316001
131CSNK1D0.46193186
132EIF2AK20.45819396
133MARK30.45021526
134EPHA30.44706680
135YES10.43711646
136CAMK1G0.43100350
137CSNK1A1L0.42873376
138DYRK1A0.42872841
139PIM10.42833499
140PRKDC0.41618262
141MAPK140.41599808
142RPS6KA10.40830113
143EIF2AK30.40613976
144PTK2B0.40043843
145PRKCG0.39863860
146MAP4K10.39356689
147ERBB20.39116490
148PRKACB0.36669996
149TLK10.33172255
150MINK10.32432755
151RPS6KA50.32324041
152ABL10.31701564
153KSR10.30694034
154CAMK2A0.30308457
155SGK10.28802470
156CSNK1A10.27502481
157SGK4940.27345261
158SGK2230.27345261

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02368548
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69854658
3Protein export_Homo sapiens_hsa030602.68303422
4One carbon pool by folate_Homo sapiens_hsa006702.63302917
5Nicotine addiction_Homo sapiens_hsa050332.46734581
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45335853
7Phototransduction_Homo sapiens_hsa047442.44500349
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38721310
9Fatty acid degradation_Homo sapiens_hsa000712.38617307
10Selenocompound metabolism_Homo sapiens_hsa004502.32886700
11Taste transduction_Homo sapiens_hsa047422.24122800
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.19967835
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13375116
14Propanoate metabolism_Homo sapiens_hsa006402.08860044
15Lysine degradation_Homo sapiens_hsa003102.06602968
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03201449
17Tryptophan metabolism_Homo sapiens_hsa003801.84141488
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82161246
19Arginine biosynthesis_Homo sapiens_hsa002201.78997298
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78587809
21Mismatch repair_Homo sapiens_hsa034301.69019769
22Carbon metabolism_Homo sapiens_hsa012001.67377579
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65945560
24Cell cycle_Homo sapiens_hsa041101.63820500
25Regulation of autophagy_Homo sapiens_hsa041401.63250105
26Fatty acid metabolism_Homo sapiens_hsa012121.59562008
27DNA replication_Homo sapiens_hsa030301.58769250
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58201469
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58095352
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57392469
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54207609
32RNA transport_Homo sapiens_hsa030131.53194590
33Linoleic acid metabolism_Homo sapiens_hsa005911.52608189
34Biosynthesis of amino acids_Homo sapiens_hsa012301.48145834
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47936387
36Ether lipid metabolism_Homo sapiens_hsa005651.47592307
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46545293
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.42626348
39Non-homologous end-joining_Homo sapiens_hsa034501.40907579
40Systemic lupus erythematosus_Homo sapiens_hsa053221.38393097
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37923694
42Morphine addiction_Homo sapiens_hsa050321.36858831
43Viral myocarditis_Homo sapiens_hsa054161.34900214
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33442255
45mRNA surveillance pathway_Homo sapiens_hsa030151.33110181
46Nitrogen metabolism_Homo sapiens_hsa009101.32223822
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31739802
48GABAergic synapse_Homo sapiens_hsa047271.31616645
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29955054
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29944206
51Butanoate metabolism_Homo sapiens_hsa006501.28699490
52RNA degradation_Homo sapiens_hsa030181.25747562
53Olfactory transduction_Homo sapiens_hsa047401.21754448
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.20081893
55Circadian entrainment_Homo sapiens_hsa047131.19261004
56Pyruvate metabolism_Homo sapiens_hsa006201.16160195
57Fat digestion and absorption_Homo sapiens_hsa049751.14303943
58Starch and sucrose metabolism_Homo sapiens_hsa005001.12792170
59Base excision repair_Homo sapiens_hsa034101.12244764
60Asthma_Homo sapiens_hsa053101.11694211
61Glutamatergic synapse_Homo sapiens_hsa047241.09237473
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08693048
63Long-term depression_Homo sapiens_hsa047301.06509893
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.06381619
65Dorso-ventral axis formation_Homo sapiens_hsa043201.05619348
66Complement and coagulation cascades_Homo sapiens_hsa046101.04829503
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02260118
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02111015
69Serotonergic synapse_Homo sapiens_hsa047261.00938744
70Fanconi anemia pathway_Homo sapiens_hsa034601.00548001
71Peroxisome_Homo sapiens_hsa041460.97757918
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97249189
73PPAR signaling pathway_Homo sapiens_hsa033200.96344825
74Spliceosome_Homo sapiens_hsa030400.94445663
75Nucleotide excision repair_Homo sapiens_hsa034200.90916689
76beta-Alanine metabolism_Homo sapiens_hsa004100.90448491
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90331302
78Viral carcinogenesis_Homo sapiens_hsa052030.86899973
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.85933348
80Phenylalanine metabolism_Homo sapiens_hsa003600.84287241
81Insulin resistance_Homo sapiens_hsa049310.83822546
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83733965
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83151428
84MicroRNAs in cancer_Homo sapiens_hsa052060.82922892
85Caffeine metabolism_Homo sapiens_hsa002320.81463195
86Small cell lung cancer_Homo sapiens_hsa052220.81006370
87Salivary secretion_Homo sapiens_hsa049700.79832544
88Dopaminergic synapse_Homo sapiens_hsa047280.78789095
89Herpes simplex infection_Homo sapiens_hsa051680.78526455
90ABC transporters_Homo sapiens_hsa020100.73350469
91Type I diabetes mellitus_Homo sapiens_hsa049400.69178790
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.68319106
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68076803
94Fatty acid elongation_Homo sapiens_hsa000620.67632625
95Homologous recombination_Homo sapiens_hsa034400.67112265
96Legionellosis_Homo sapiens_hsa051340.65774848
97Adherens junction_Homo sapiens_hsa045200.65272880
98Retinol metabolism_Homo sapiens_hsa008300.64408914
99Oocyte meiosis_Homo sapiens_hsa041140.62889189
100Sulfur metabolism_Homo sapiens_hsa009200.62727789
101Dilated cardiomyopathy_Homo sapiens_hsa054140.60831383
102Insulin secretion_Homo sapiens_hsa049110.60602780
103Renin secretion_Homo sapiens_hsa049240.56853622
104Influenza A_Homo sapiens_hsa051640.56827340
105Endometrial cancer_Homo sapiens_hsa052130.55523059
106p53 signaling pathway_Homo sapiens_hsa041150.55066772
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.54766106
108Staphylococcus aureus infection_Homo sapiens_hsa051500.53707034
109Tyrosine metabolism_Homo sapiens_hsa003500.53601938
110Glycerolipid metabolism_Homo sapiens_hsa005610.53486633
111Histidine metabolism_Homo sapiens_hsa003400.53402595
112Alcoholism_Homo sapiens_hsa050340.53121292
113Ovarian steroidogenesis_Homo sapiens_hsa049130.52522660
114Cholinergic synapse_Homo sapiens_hsa047250.50871117
115Collecting duct acid secretion_Homo sapiens_hsa049660.50673199
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49519186
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.49213968
118Pentose phosphate pathway_Homo sapiens_hsa000300.49191840
119Purine metabolism_Homo sapiens_hsa002300.49184633
120Vitamin digestion and absorption_Homo sapiens_hsa049770.48887174
121Calcium signaling pathway_Homo sapiens_hsa040200.48286860
122Measles_Homo sapiens_hsa051620.47937270
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47051876
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46654507
125Glucagon signaling pathway_Homo sapiens_hsa049220.46367170
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46079610
127Sphingolipid metabolism_Homo sapiens_hsa006000.45572200
128Arachidonic acid metabolism_Homo sapiens_hsa005900.43470179
129Toxoplasmosis_Homo sapiens_hsa051450.42662990
130RNA polymerase_Homo sapiens_hsa030200.42093750
131Type II diabetes mellitus_Homo sapiens_hsa049300.41797582
132Arginine and proline metabolism_Homo sapiens_hsa003300.41412905
133Chronic myeloid leukemia_Homo sapiens_hsa052200.40785016
134AMPK signaling pathway_Homo sapiens_hsa041520.40480950
135Bile secretion_Homo sapiens_hsa049760.40356766
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39151114
137mTOR signaling pathway_Homo sapiens_hsa041500.39102717
138HTLV-I infection_Homo sapiens_hsa051660.37849851
139Chemical carcinogenesis_Homo sapiens_hsa052040.37712682
140Pyrimidine metabolism_Homo sapiens_hsa002400.36391045
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36366324
142Cocaine addiction_Homo sapiens_hsa050300.36249947
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36212218
144Steroid biosynthesis_Homo sapiens_hsa001000.36131759
145Epstein-Barr virus infection_Homo sapiens_hsa051690.35360961
146Basal transcription factors_Homo sapiens_hsa030220.35302356
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34498664
148Vitamin B6 metabolism_Homo sapiens_hsa007500.33700578
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.33104165
150TGF-beta signaling pathway_Homo sapiens_hsa043500.33044664
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.32622514
152cAMP signaling pathway_Homo sapiens_hsa040240.32464390
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.31190081
154Circadian rhythm_Homo sapiens_hsa047100.30510447
155Amphetamine addiction_Homo sapiens_hsa050310.27576400
156Fatty acid biosynthesis_Homo sapiens_hsa000610.27499739
157Allograft rejection_Homo sapiens_hsa053300.27390148

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