PPL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hair cycle (GO:0042633)8.65594902
2molting cycle (GO:0042303)8.65594902
3hemidesmosome assembly (GO:0031581)8.55455368
4multicellular organismal water homeostasis (GO:0050891)7.32670775
5keratinocyte differentiation (GO:0030216)6.89232160
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.60213633
7water homeostasis (GO:0030104)6.28944154
8peptide cross-linking (GO:0018149)6.24850167
9epidermal cell differentiation (GO:0009913)5.41487947
10intermediate filament organization (GO:0045109)5.29364228
11skin morphogenesis (GO:0043589)5.08965734
12epidermis development (GO:0008544)5.03024184
13keratinocyte proliferation (GO:0043616)4.93185318
14surfactant homeostasis (GO:0043129)4.34445108
15ectoderm development (GO:0007398)4.18341511
16apical protein localization (GO:0045176)4.17629572
17gap junction assembly (GO:0016264)4.03553195
18linoleic acid metabolic process (GO:0043651)4.03371301
19chemical homeostasis within a tissue (GO:0048875)3.95985533
20sphingoid metabolic process (GO:0046519)3.72148202
21detection of bacterium (GO:0016045)3.70723384
22sphingosine metabolic process (GO:0006670)3.62751999
23polarized epithelial cell differentiation (GO:0030859)3.59408086
24regulation of phospholipase A2 activity (GO:0032429)3.57128294
25phospholipid efflux (GO:0033700)3.57056817
26asymmetric protein localization (GO:0008105)3.46536785
27regulation of ruffle assembly (GO:1900027)3.46177385
28keratinocyte development (GO:0003334)3.42388340
29intermediate filament cytoskeleton organization (GO:0045104)3.34418646
30plasma membrane repair (GO:0001778)3.31608497
31fatty acid elongation (GO:0030497)3.30905048
32cell-substrate junction assembly (GO:0007044)3.29242404
33intermediate filament-based process (GO:0045103)3.26870700
34long-chain fatty acid biosynthetic process (GO:0042759)3.26214840
35interferon-gamma secretion (GO:0072643)3.23701724
36primary alcohol catabolic process (GO:0034310)3.23465453
37diol metabolic process (GO:0034311)3.18974107
38positive regulation of epidermal cell differentiation (GO:0045606)3.18621209
39atrioventricular valve morphogenesis (GO:0003181)3.18160006
40negative regulation of cell fate specification (GO:0009996)3.17271093
41detection of other organism (GO:0098543)3.16858713
42adhesion of symbiont to host cell (GO:0044650)3.14979773
43virion attachment to host cell (GO:0019062)3.14979773
44epithelial cell-cell adhesion (GO:0090136)3.13982925
45regulation of keratinocyte differentiation (GO:0045616)3.08565669
46fibrinolysis (GO:0042730)3.07475234
47regulation of transforming growth factor beta1 production (GO:0032908)3.07240322
48negative regulation of keratinocyte proliferation (GO:0010839)3.03835266
49gland morphogenesis (GO:0022612)3.03635975
50planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99071010
51positive regulation of interleukin-8 secretion (GO:2000484)2.99052139
52ethanol metabolic process (GO:0006067)2.95225881
53hormone catabolic process (GO:0042447)2.93582433
54cell-cell junction assembly (GO:0007043)2.90155066
55skin development (GO:0043588)2.89955345
56regulation of cardioblast differentiation (GO:0051890)2.86166451
57endosome organization (GO:0007032)2.83773236
58regulation of cholesterol homeostasis (GO:2000188)2.81229537
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80028541
60regulation of keratinocyte proliferation (GO:0010837)2.79882763
61hair cell differentiation (GO:0035315)2.75481256
62regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75279629
63regulation of establishment of planar polarity (GO:0090175)2.74882495
64ventricular cardiac muscle cell action potential (GO:0086005)2.74012376
65negative regulation of lipase activity (GO:0060192)2.73824593
66regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72019850
67regulation of cell proliferation involved in kidney development (GO:1901722)2.71817351
68activation of Rac GTPase activity (GO:0032863)2.71241674
69O-glycan processing (GO:0016266)2.68914959
70adhesion of symbiont to host (GO:0044406)2.67091479
71positive regulation of keratinocyte differentiation (GO:0045618)2.65781471
72regulation of interleukin-8 secretion (GO:2000482)2.65592463
73columnar/cuboidal epithelial cell development (GO:0002066)2.63604539
74regulation of transforming growth factor beta2 production (GO:0032909)2.62888448
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.61366245
76tight junction assembly (GO:0070830)2.61030811
77positive regulation of cholesterol efflux (GO:0010875)2.60315577
78hypotonic response (GO:0006971)2.59862667
79positive regulation of glomerulus development (GO:0090193)2.59139118
80positive regulation of cholesterol transport (GO:0032376)2.58388484
81positive regulation of sterol transport (GO:0032373)2.58388484
82regulation of chemokine secretion (GO:0090196)2.58299941
83lateral sprouting from an epithelium (GO:0060601)2.57808482
84establishment of apical/basal cell polarity (GO:0035089)2.57374327
85epithelium development (GO:0060429)2.56368109
86lung epithelium development (GO:0060428)2.54443549
87negative regulation of stress fiber assembly (GO:0051497)2.52750946
88establishment of planar polarity (GO:0001736)2.52432179
89establishment of tissue polarity (GO:0007164)2.52432179
90regulation of natural killer cell differentiation (GO:0032823)2.52103976
91hippo signaling (GO:0035329)2.51786652
92membrane raft organization (GO:0031579)2.51313105
93cell-substrate adherens junction assembly (GO:0007045)2.51080488
94focal adhesion assembly (GO:0048041)2.51080488
95negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50025118
96glucosamine-containing compound catabolic process (GO:1901072)2.49555062
97morphogenesis of embryonic epithelium (GO:0016331)2.49553406
98long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.49454633
99endothelial cell chemotaxis (GO:0035767)2.49109244
100regulation of heart rate by cardiac conduction (GO:0086091)2.48650790
101non-canonical Wnt signaling pathway (GO:0035567)2.48491507
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48198133
103COPI coating of Golgi vesicle (GO:0048205)2.47660341
104Golgi transport vesicle coating (GO:0048200)2.47660341
105lipoxygenase pathway (GO:0019372)2.47335174
106negative regulation of cell fate commitment (GO:0010454)2.46287617
107cell communication involved in cardiac conduction (GO:0086065)2.42192125
108cell junction assembly (GO:0034329)2.41894442
109eyelid development in camera-type eye (GO:0061029)2.41725505
110epithelial cell differentiation (GO:0030855)2.41459657
111cell junction organization (GO:0034330)2.40701572
112adherens junction assembly (GO:0034333)2.39708755
113glandular epithelial cell differentiation (GO:0002067)2.39031376
114positive regulation of p38MAPK cascade (GO:1900745)2.37715976
115lung lobe morphogenesis (GO:0060463)2.37027924
116hair follicle morphogenesis (GO:0031069)2.36833185
117semaphorin-plexin signaling pathway (GO:0071526)2.35997968
118regulation of p38MAPK cascade (GO:1900744)2.35104581
119fatty-acyl-CoA metabolic process (GO:0035337)2.34138219
120positive regulation of epidermis development (GO:0045684)2.33357186
121long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.32186256
122protein localization to endosome (GO:0036010)2.31777210
123regulation of endothelial cell chemotaxis (GO:2001026)2.31493453
124regulation of hair follicle development (GO:0051797)2.30661060
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.30487755
126intestinal epithelial cell development (GO:0060576)2.29139543
127positive regulation of hair follicle development (GO:0051798)2.28944274
128positive regulation of hair cycle (GO:0042635)2.28944274
129retinal metabolic process (GO:0042574)2.28217204
130cardiac right ventricle morphogenesis (GO:0003215)2.27543558
131very long-chain fatty acid metabolic process (GO:0000038)2.26879888
132positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.26570178
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.23486420
134epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22013347
135regulation of glomerular filtration (GO:0003093)2.21519341
136molting cycle process (GO:0022404)2.21059258
137hair cycle process (GO:0022405)2.21059258
138wound healing (GO:0042060)2.19768845
139regulation of epidermis development (GO:0045682)2.19504372
140peptidyl-glutamic acid carboxylation (GO:0017187)2.18180701
141protein carboxylation (GO:0018214)2.18180701
142complement activation, alternative pathway (GO:0006957)2.17517199
143desmosome organization (GO:0002934)12.1666243
144establishment of skin barrier (GO:0061436)11.4002182
145* keratinization (GO:0031424)10.6151801
146regulation of water loss via skin (GO:0033561)10.4102913

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.14178440
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.00360601
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.73848541
4* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.58651904
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48911534
6* ESR1_21235772_ChIP-Seq_MCF-7_Human2.47418640
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.43476618
8ZNF263_19887448_ChIP-Seq_K562_Human2.36596069
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35363083
10* ESR2_21235772_ChIP-Seq_MCF-7_Human2.25066400
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.19332388
12* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15625364
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.10453423
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03473988
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03473988
16TP63_17297297_ChIP-ChIP_HaCaT_Human13.1824435
17* LXR_22158963_ChIP-Seq_LIVER_Mouse1.90837259
18* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88733098
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71647518
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63185000
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61730254
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59612612
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58842022
24CLOCK_20551151_ChIP-Seq_293T_Human1.56940212
25* SOX2_20726797_ChIP-Seq_SW620_Human1.56036907
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52225775
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51502438
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44455802
29RACK7_27058665_Chip-Seq_MCF-7_Human1.43353748
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.40274558
31GATA4_25053715_ChIP-Seq_YYC3_Human1.38983151
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38302656
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37511032
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36494952
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36478461
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.36308495
37TP63_23658742_ChIP-Seq_EP156T_Human1.35898558
38* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35217355
39* RUNX1_27514584_Chip-Seq_MCF-7_Human1.33952963
40* CJUN_26792858_Chip-Seq_BT549_Human1.32980319
41ATF3_27146783_Chip-Seq_COLON_Human1.28148928
42TCF4_18268006_ChIP-ChIP_LS174T_Human1.28107795
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27056376
44* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25419076
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.25049692
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23481594
47GATA6_25053715_ChIP-Seq_YYC3_Human1.21107408
48TP63_22573176_ChIP-Seq_HFKS_Human1.20818267
49* KLF5_25053715_ChIP-Seq_YYC3_Human1.20503462
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18960683
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17011774
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16663743
53CDX2_20551321_ChIP-Seq_CACO-2_Human1.12848817
54GATA1_22025678_ChIP-Seq_K562_Human1.12343743
55AHR_22903824_ChIP-Seq_MCF-7_Human1.10845729
56* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10501586
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10201390
58* SMC4_20622854_ChIP-Seq_HELA_Human1.09850751
59UBF1/2_26484160_Chip-Seq_HMECs_Human1.08155172
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06588036
61TP53_18474530_ChIP-ChIP_U2OS_Human1.05465220
62BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04618068
63RXR_22108803_ChIP-Seq_LS180_Human1.03358511
64CREB1_26743006_Chip-Seq_LNCaP_Human1.01994435
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.00591523
66NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98644930
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98103652
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96332276
69LXR_22292898_ChIP-Seq_THP-1_Human0.96260714
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94742990
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94483442
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93137220
73TET1_21490601_ChIP-Seq_MESCs_Mouse0.92672669
74KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92636690
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92496575
76CEBPB_22108803_ChIP-Seq_LS180_Human0.91510736
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90613360
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.90464365
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89024598
80FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87995369
81EP300_21415370_ChIP-Seq_HL-1_Mouse0.85916687
82* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85521959
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.85399657
84* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85099063
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84135168
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83639213
87TBX20_22328084_ChIP-Seq_HEART_Mouse0.83337548
88TBX20_22080862_ChIP-Seq_HEART_Mouse0.83337548
89CHD1_26751641_Chip-Seq_LNCaP_Human0.82339074
90* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82105592
91WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81925496
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81865545
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81859376
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.81239420
95* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79526360
96BCAT_22108803_ChIP-Seq_LS180_Human0.78839161
97EGR1_19032775_ChIP-ChIP_M12_Human0.78231428
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.78043677
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.77811716
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77667712
101AR_21572438_ChIP-Seq_LNCaP_Human0.77486550
102* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76417605
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76205708
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.76104783
105AR_21909140_ChIP-Seq_LNCAP_Human0.75465148
106GATA6_21074721_ChIP-Seq_CACO-2_Human0.75348572
107* CTCF_27219007_Chip-Seq_Bcells_Human0.74958106
108TCF7_22412390_ChIP-Seq_EML_Mouse0.74917449
109FOXM1_26456572_ChIP-Seq_MCF-7_Human0.74862576
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74032687
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73681257
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73284232
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71448115
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70800223
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.70768832
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.69201170
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.68882329
118TP53_16413492_ChIP-PET_HCT116_Human0.68700125
119* KDM2B_26808549_Chip-Seq_K562_Human0.68494833
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67478130
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.66784567
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64798019
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64798019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.20903841
2MP0005275_abnormal_skin_tensile5.75436206
3MP0010234_abnormal_vibrissa_follicle5.36792779
4MP0005501_abnormal_skin_physiology4.43933252
5MP0000579_abnormal_nail_morphology4.16983999
6MP0003941_abnormal_skin_development3.80389054
7MP0002254_reproductive_system_inflammat3.45629130
8MP0002060_abnormal_skin_morphology3.42788886
9MP0001216_abnormal_epidermal_layer3.17386385
10MP0010678_abnormal_skin_adnexa3.14425859
11MP0000383_abnormal_hair_follicle3.05988747
12MP0003705_abnormal_hypodermis_morpholog3.02807182
13MP0002098_abnormal_vibrissa_morphology3.00141956
14MP0004381_abnormal_hair_follicle2.86166924
15MP0009780_abnormal_chondrocyte_physiolo2.85340895
16MP0010771_integument_phenotype2.78183884
17MP0000647_abnormal_sebaceous_gland2.69342278
18MP0003453_abnormal_keratinocyte_physiol2.62478366
19MP0005451_abnormal_body_composition2.50193373
20MP0004947_skin_inflammation2.49869743
21MP0000377_abnormal_hair_follicle2.35948988
22MP0000427_abnormal_hair_cycle2.28438950
23MP0000467_abnormal_esophagus_morphology2.23714333
24MP0003566_abnormal_cell_adhesion1.94225229
25MP0003191_abnormal_cellular_cholesterol1.88592127
26MP0000762_abnormal_tongue_morphology1.86921241
27MP0000566_synostosis1.66703215
28MP0004185_abnormal_adipocyte_glucose1.65149632
29MP0004043_abnormal_pH_regulation1.64165247
30MP0009931_abnormal_skin_appearance1.63349707
31MP0001243_abnormal_dermal_layer1.62790318
32MP0001191_abnormal_skin_condition1.47486920
33MP0004782_abnormal_surfactant_physiolog1.44000870
34MP0005377_hearing/vestibular/ear_phenot1.40420352
35MP0003878_abnormal_ear_physiology1.40420352
36MP0005085_abnormal_gallbladder_physiolo1.34774731
37MP0001346_abnormal_lacrimal_gland1.30891100
38MP0000367_abnormal_coat/_hair1.30656903
39MP0002234_abnormal_pharynx_morphology1.25860850
40MP0002139_abnormal_hepatobiliary_system1.21615112
41MP0008875_abnormal_xenobiotic_pharmacok1.18394866
42MP0009053_abnormal_anal_canal1.15832696
43MP0005360_urolithiasis1.12216595
44MP0009379_abnormal_foot_pigmentation1.12215177
45MP0000003_abnormal_adipose_tissue1.12001300
46MP0000537_abnormal_urethra_morphology1.04175839
47MP0010352_gastrointestinal_tract_polyps0.99700953
48MP0004019_abnormal_vitamin_homeostasis0.99279133
49MP0003252_abnormal_bile_duct0.97806875
50MP0005023_abnormal_wound_healing0.97771640
51MP0005503_abnormal_tendon_morphology0.95810674
52MP0000678_abnormal_parathyroid_gland0.93183710
53MP0004885_abnormal_endolymph0.93110458
54MP0005365_abnormal_bile_salt0.90472947
55MP0004264_abnormal_extraembryonic_tissu0.90317530
56MP0008438_abnormal_cutaneous_collagen0.90187504
57MP0001851_eye_inflammation0.87674574
58MP0002909_abnormal_adrenal_gland0.86292802
59MP0001849_ear_inflammation0.86076594
60MP0001666_abnormal_nutrient_absorption0.84723316
61MP0001340_abnormal_eyelid_morphology0.84541524
62MP0002009_preneoplasia0.83208347
63MP0004272_abnormal_basement_membrane0.83047440
64MP0005083_abnormal_biliary_tract0.78003149
65MP0000627_abnormal_mammary_gland0.74410759
66MP0009384_cardiac_valve_regurgitation0.71536275
67MP0010030_abnormal_orbit_morphology0.70215504
68MP0006054_spinal_hemorrhage0.69934911
69MP0005666_abnormal_adipose_tissue0.69840787
70MP0008004_abnormal_stomach_pH0.66879017
71MP0005076_abnormal_cell_differentiation0.66091200
72MP0010329_abnormal_lipoprotein_level0.65941867
73MP0003011_delayed_dark_adaptation0.65911813
74MP0000465_gastrointestinal_hemorrhage0.64895688
75MP0002108_abnormal_muscle_morphology0.63640199
76MP0001765_abnormal_ion_homeostasis0.62300705
77MP0002877_abnormal_melanocyte_morpholog0.61753878
78MP0003950_abnormal_plasma_membrane0.60468625
79MP0000013_abnormal_adipose_tissue0.59004264
80MP0002138_abnormal_hepatobiliary_system0.58855426
81MP0009840_abnormal_foam_cell0.57356043
82MP0005257_abnormal_intraocular_pressure0.56733555
83MP0003300_gastrointestinal_ulcer0.55918265
84MP0001784_abnormal_fluid_regulation0.55347638
85MP0006138_congestive_heart_failure0.55323129
86MP0005375_adipose_tissue_phenotype0.54549597
87MP0003045_fibrosis0.54196584
88MP0001756_abnormal_urination0.52425442
89MP0002282_abnormal_trachea_morphology0.52255800
90MP0008961_abnormal_basal_metabolism0.52219341
91MP0000538_abnormal_urinary_bladder0.52077225
92MP0001958_emphysema0.50646437
93MP0000516_abnormal_urinary_system0.48680655
94MP0005367_renal/urinary_system_phenotyp0.48680655
95MP0002166_altered_tumor_susceptibility0.48518013
96MP0001188_hyperpigmentation0.47944184
97MP0003091_abnormal_cell_migration0.45129112
98MP0003638_abnormal_response/metabolism_0.44801386
99MP0002118_abnormal_lipid_homeostasis0.43468656
100MP0002249_abnormal_larynx_morphology0.43219363
101MP0002177_abnormal_outer_ear0.43137325
102MP0001177_atelectasis0.42171483
103MP0002896_abnormal_bone_mineralization0.41833779
104MP0005248_abnormal_Harderian_gland0.40296724
105MP0003755_abnormal_palate_morphology0.39884284
106MP0002111_abnormal_tail_morphology0.39211241
107MP0009643_abnormal_urine_homeostasis0.38062405
108MP0005670_abnormal_white_adipose0.37915878
109MP0002006_tumorigenesis0.37680942
110MP0000609_abnormal_liver_physiology0.37550926
111MP0004858_abnormal_nervous_system0.37395760
112MP0002168_other_aberrant_phenotype0.36356057
113MP0003115_abnormal_respiratory_system0.35971777
114MP0001502_abnormal_circadian_rhythm0.35541546
115MP0000462_abnormal_digestive_system0.35061722
116MP0001299_abnormal_eye_distance/0.34494800
117MP0005508_abnormal_skeleton_morphology0.33510644
118MP0004197_abnormal_fetal_growth/weight/0.33400488
119MP0000470_abnormal_stomach_morphology0.33288083
120MP0010368_abnormal_lymphatic_system0.32488409
121MP0005409_darkened_coat_color0.32037521
122MP0002089_abnormal_postnatal_growth/wei0.31959962
123MP0002095_abnormal_skin_pigmentation0.30854020
124MP0003195_calcinosis0.30348259
125MP0002697_abnormal_eye_size0.30061319
126MP0002233_abnormal_nose_morphology0.29942948
127MP0000613_abnormal_salivary_gland0.29730465
128MP0001881_abnormal_mammary_gland0.29612767

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)6.92168983
2Right ventricular cardiomyopathy (HP:0011663)6.62231053
3Plantar hyperkeratosis (HP:0007556)6.47530286
4Onycholysis (HP:0001806)6.35908380
5Woolly hair (HP:0002224)6.32342127
6Abnormality of nail color (HP:0100643)6.12426728
7Increased IgE level (HP:0003212)5.95613781
8Palmoplantar hyperkeratosis (HP:0000972)5.77851681
9Fragile nails (HP:0001808)5.72932815
10Congenital ichthyosiform erythroderma (HP:0007431)5.64685890
11Milia (HP:0001056)5.55417008
12Palmar hyperkeratosis (HP:0010765)5.42647968
13Pili torti (HP:0003777)5.19310356
14Thick nail (HP:0001805)4.45979997
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.37900809
16Nail dystrophy (HP:0008404)4.24721041
17Erythroderma (HP:0001019)4.22288776
18Erythema (HP:0010783)4.03111089
19Lip pit (HP:0100267)4.02994307
20Abnormal blistering of the skin (HP:0008066)3.97737971
21Conjunctival hamartoma (HP:0100780)3.97526065
22Alopecia of scalp (HP:0002293)3.92530399
23Atrophic scars (HP:0001075)3.86329880
24Parakeratosis (HP:0001036)3.68060697
25Hyporeflexia of lower limbs (HP:0002600)3.49731243
26Ectropion (HP:0000656)3.42302411
27Corneal erosion (HP:0200020)3.41950909
28Abnormal hair laboratory examination (HP:0003328)3.41118015
29Absent eyelashes (HP:0000561)3.29834576
30Gangrene (HP:0100758)3.22940245
31Curly hair (HP:0002212)3.12619403
32Advanced eruption of teeth (HP:0006288)3.11494807
33Distal lower limb muscle weakness (HP:0009053)3.09546144
34Natal tooth (HP:0000695)3.07351064
35Palmoplantar keratoderma (HP:0000982)3.05936396
36Ventricular tachycardia (HP:0004756)3.02483792
37Acanthosis nigricans (HP:0000956)2.95705546
38Hyperactive renin-angiotensin system (HP:0000841)2.94680035
39Increased connective tissue (HP:0009025)2.88984259
40Pruritus (HP:0000989)2.88330841
41Hypohidrosis (HP:0000966)2.80520672
42Sparse eyelashes (HP:0000653)2.72797488
43Fragile skin (HP:0001030)2.53887494
44Ridged nail (HP:0001807)2.51421875
45Follicular hyperkeratosis (HP:0007502)2.48331676
46Pustule (HP:0200039)2.47373276
47Abnormality of the dental root (HP:0006486)2.41564682
48Taurodontia (HP:0000679)2.41564682
49Abnormality of permanent molar morphology (HP:0011071)2.41564682
50Hamartoma of the eye (HP:0010568)2.41291084
51Chronic bronchitis (HP:0004469)2.37050841
52Abnormality of molar (HP:0011077)2.34653109
53Abnormality of molar morphology (HP:0011070)2.34653109
54Hyperkalemia (HP:0002153)2.28596013
55Sparse scalp hair (HP:0002209)2.27675352
56Xanthomatosis (HP:0000991)2.24874226
57Dehydration (HP:0001944)2.24147998
58Absent hair (HP:0002298)2.23982363
59Abnormality of the gastric mucosa (HP:0004295)2.21246163
60Lack of skin elasticity (HP:0100679)2.19690484
61Oligodontia (HP:0000677)2.19631131
62Abnormality of the dental pulp (HP:0006479)2.18834881
63Abnormality of small intestinal villus morphology (HP:0011472)2.18210192
64Villous atrophy (HP:0011473)2.18210192
65Brittle hair (HP:0002299)2.17380191
66Oral leukoplakia (HP:0002745)2.14328469
67Aplasia cutis congenita (HP:0001057)2.13373123
68Epidermoid cyst (HP:0200040)2.07602609
69Intrahepatic cholestasis (HP:0001406)2.07030752
70Type 1 muscle fiber predominance (HP:0003803)2.03633686
71Deep venous thrombosis (HP:0002625)2.01566753
72Malnutrition (HP:0004395)1.99444563
73Blepharitis (HP:0000498)1.98600623
74Hypoplasia of dental enamel (HP:0006297)1.97760537
75Selective tooth agenesis (HP:0001592)1.93134322
76Abnormality of the Achilles tendon (HP:0005109)1.90825194
77Hypoplastic labia majora (HP:0000059)1.88111028
78Abnormality of monocarboxylic acid metabolism (HP:0010996)1.87996318
79Septate vagina (HP:0001153)1.87914099
80Neonatal death (HP:0003811)1.86744790
81Congenital, generalized hypertrichosis (HP:0004540)1.86532676
82Achilles tendon contracture (HP:0001771)1.86289979
83Furrowed tongue (HP:0000221)1.84560740
84Interstitial pulmonary disease (HP:0006530)1.84438203
85Mildly elevated creatine phosphokinase (HP:0008180)1.84191550
86Abnormality of the neuromuscular junction (HP:0003398)1.82413988
87Fatigable weakness (HP:0003473)1.82413988
88Labial hypoplasia (HP:0000066)1.81951927
89Round ear (HP:0100830)1.81371542
90Short nail (HP:0001799)1.81029950
91Abnormality of the salivary glands (HP:0010286)1.79626491
92Popliteal pterygium (HP:0009756)1.78468969
93Ventricular fibrillation (HP:0001663)1.77548648
94Areflexia of lower limbs (HP:0002522)1.77010358
95Melanocytic nevus (HP:0000995)1.72397147
96Obstructive sleep apnea (HP:0002870)1.72389217
97Abnormality of secondary sexual hair (HP:0009888)1.71816678
98Abnormality of the axillary hair (HP:0100134)1.71816678
99Laryngomalacia (HP:0001601)1.70659711
100Broad face (HP:0000283)1.70312710
101Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69635832
102Hyperhidrosis (HP:0000975)1.69100887
103Abnormality of the labia majora (HP:0012881)1.67212020
104Anonychia (HP:0001798)1.66725602
105Bronchomalacia (HP:0002780)1.65298397
106Nasal polyposis (HP:0100582)1.63210813
107Hypoplastic female external genitalia (HP:0012815)1.63039682
108Aplasia involving bones of the extremities (HP:0009825)1.63022614
109Aplasia involving bones of the upper limbs (HP:0009823)1.63022614
110Eczematoid dermatitis (HP:0000976)1.61252776
111Malignant hyperthermia (HP:0002047)1.61051532
112Ankyloglossia (HP:0010296)1.60536672
113Skin ulcer (HP:0200042)1.60182923
114Distal lower limb amyotrophy (HP:0008944)1.60153117
115Cardiovascular calcification (HP:0011915)1.59963042
116Trismus (HP:0000211)1.59951703
117Hypoalphalipoproteinemia (HP:0003233)1.58999144
118Down-sloping shoulders (HP:0200021)1.58212798
119Complement deficiency (HP:0004431)1.58114163
120Pterygium (HP:0001059)1.57549821
121Dry skin (HP:0000958)1.56562369
122Abnormality of the distal phalanges of the toes (HP:0010182)1.56436785
123Vascular calcification (HP:0004934)1.56049302
124Osteolytic defects of the hand bones (HP:0009699)1.55712952
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.55712952
126Abnormality of complement system (HP:0005339)1.54929379
127Sudden death (HP:0001699)1.52847406
128Abnormal hemoglobin (HP:0011902)1.52143921
129Premature rupture of membranes (HP:0001788)1.50397545
130Hypergammaglobulinemia (HP:0010702)1.50026197
131Muscle fiber splitting (HP:0003555)1.49912795
132Distal arthrogryposis (HP:0005684)1.46769196
133Esophageal atresia (HP:0002032)1.46585575
134Severe Myopia (HP:0011003)1.46270277
135Aplasia of the phalanges of the hand (HP:0009802)1.45732337

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.05017006
2MAPKAPK33.98707478
3EPHA23.75962613
4MST43.55589806
5LATS13.34226796
6FER3.33428690
7MAP3K33.17278811
8ERN12.98139721
9MAP3K22.42151374
10EPHB22.33529495
11TTN2.33452737
12RPS6KB22.24109209
13TRIB32.11481307
14SIK11.92831377
15PTK61.88918813
16PIK3CG1.88045003
17FGFR41.84075276
18RIPK11.81962563
19FGFR21.72227609
20MET1.71270921
21LRRK21.59598693
22TRPM71.59009743
23EPHB11.51252683
24TGFBR21.47027133
25CDK121.44261889
26FGFR11.43496416
27SMG11.39603688
28EPHA31.39480145
29STK241.37152891
30FRK1.31763837
31STK101.26718869
32MAP3K71.25850469
33PTK21.24800979
34EEF2K1.21870149
35MAP3K121.20967179
36ICK1.16413301
37STK381.12937096
38CDK61.12266563
39DYRK1B1.11380767
40TAOK11.10423528
41MAPK151.05162272
42MAP3K11.03860870
43STK38L0.96180273
44FGFR30.93845690
45MAP3K110.93046401
46PBK0.90102008
47MAP2K30.88207570
48TGFBR10.87985304
49MAP2K60.86131791
50PKN20.85153407
51ERBB30.84870113
52WNK10.83336962
53SGK30.82639691
54MAP2K20.81809942
55BCR0.80517305
56MAP2K10.79928622
57STK30.79246068
58ERBB20.79125867
59RPS6KA40.77471610
60LATS20.77030437
61OBSCN0.75735522
62SGK2230.74302427
63SGK4940.74302427
64NTRK10.72305505
65MYLK0.72140750
66RPS6KA20.71454348
67PRKD10.70282622
68ERBB40.69994930
69MAPKAPK20.69154299
70STK390.67527237
71PDGFRA0.66829936
72PRKD20.65529739
73HIPK20.65411906
74DMPK0.65312337
75BMX0.65006262
76NEK90.64740662
77PIM20.64477646
78LMTK20.64335033
79BCKDK0.64269938
80CDC42BPA0.63162121
81TESK10.61851728
82IRAK30.61610752
83PRKCI0.60513295
84MAP3K90.58761109
85TYK20.58688482
86NEK60.58547551
87DDR20.57204343
88CAMK1G0.55133561
89PAK30.53440578
90GSK3A0.52441441
91GRK10.46273117
92BLK0.45622986
93MAPKAPK50.45471833
94SGK20.45222198
95RET0.44529692
96DAPK20.42369959
97RPS6KB10.41898830
98JAK20.39770980
99PDGFRB0.39055088
100RPS6KA10.38812141
101KSR20.37038429
102MTOR0.35898285
103ROCK10.35847793
104ILK0.35079105
105MAP3K60.35004618
106CHUK0.34832282
107PRKAA20.34193143
108MAP3K140.34181400
109MAPK110.34080464
110JAK10.33813084
111AKT20.32990720
112TIE10.32618651
113MAP2K40.30829960
114INSRR0.30479747
115PAK40.30261173
116MELK0.29098763
117PDPK10.28958062
118PAK20.28899935
119ITK0.28322752
120CDK90.27888202
121IRAK10.27266044
122ABL20.27094810
123CSNK1D0.25462731
124ARAF0.25006921
125MAP3K50.24130441
126IRAK20.24104261
127PHKG10.24069614
128PHKG20.24069614
129ABL10.23749934
130TBK10.23588594
131SCYL20.22909588
132MUSK0.22190634
133EGFR0.21561474
134SRC0.20810023
135NLK0.19455017
136NME10.18176155
137CAMK1D0.17963155
138MARK20.17632338

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003402.50245055
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.45440457
3Phenylalanine metabolism_Homo sapiens_hsa003602.31989164
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.27753293
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.27368803
6Circadian rhythm_Homo sapiens_hsa047102.16557689
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.13125648
8Chemical carcinogenesis_Homo sapiens_hsa052042.12023808
9Nitrogen metabolism_Homo sapiens_hsa009102.09532981
10Caffeine metabolism_Homo sapiens_hsa002322.05664514
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97785191
12Linoleic acid metabolism_Homo sapiens_hsa005911.94155063
13Fatty acid elongation_Homo sapiens_hsa000621.93631185
14Fat digestion and absorption_Homo sapiens_hsa049751.86624604
15Fatty acid degradation_Homo sapiens_hsa000711.86316228
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85586759
17Complement and coagulation cascades_Homo sapiens_hsa046101.83679194
18Retinol metabolism_Homo sapiens_hsa008301.82872007
19ECM-receptor interaction_Homo sapiens_hsa045121.73547964
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72134443
21Staphylococcus aureus infection_Homo sapiens_hsa051501.69848824
22Arginine biosynthesis_Homo sapiens_hsa002201.66072085
23Tyrosine metabolism_Homo sapiens_hsa003501.65254608
24ABC transporters_Homo sapiens_hsa020101.63834939
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60365589
26Adherens junction_Homo sapiens_hsa045201.57775738
27PPAR signaling pathway_Homo sapiens_hsa033201.51676288
28Arachidonic acid metabolism_Homo sapiens_hsa005901.51337891
29Basal cell carcinoma_Homo sapiens_hsa052171.51330644
30Sphingolipid metabolism_Homo sapiens_hsa006001.49956350
31beta-Alanine metabolism_Homo sapiens_hsa004101.45871977
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43010750
33Tryptophan metabolism_Homo sapiens_hsa003801.41598490
34Tight junction_Homo sapiens_hsa045301.32421900
35Fatty acid metabolism_Homo sapiens_hsa012121.23134941
36Bladder cancer_Homo sapiens_hsa052191.20221096
37Ovarian steroidogenesis_Homo sapiens_hsa049131.20150979
38Insulin signaling pathway_Homo sapiens_hsa049101.17512645
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16178318
40Fatty acid biosynthesis_Homo sapiens_hsa000611.14968397
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11296292
42Hippo signaling pathway_Homo sapiens_hsa043901.10090778
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.09419347
44Steroid biosynthesis_Homo sapiens_hsa001001.08536247
45Amoebiasis_Homo sapiens_hsa051461.07424211
46Proteoglycans in cancer_Homo sapiens_hsa052051.07296810
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05822261
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03947651
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03153052
50Salivary secretion_Homo sapiens_hsa049701.02446479
51Bile secretion_Homo sapiens_hsa049761.01243319
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01224170
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98911422
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98319905
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97685403
56Inositol phosphate metabolism_Homo sapiens_hsa005620.96657820
57Glucagon signaling pathway_Homo sapiens_hsa049220.96599510
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95806769
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93260660
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.91093600
61AMPK signaling pathway_Homo sapiens_hsa041520.90048052
62Renal cell carcinoma_Homo sapiens_hsa052110.88962363
63Glutathione metabolism_Homo sapiens_hsa004800.88320025
64Choline metabolism in cancer_Homo sapiens_hsa052310.88174094
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87695696
66Hedgehog signaling pathway_Homo sapiens_hsa043400.87353501
67Protein digestion and absorption_Homo sapiens_hsa049740.87064113
68Sulfur metabolism_Homo sapiens_hsa009200.82981033
69Endocytosis_Homo sapiens_hsa041440.82631156
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80888051
71Ether lipid metabolism_Homo sapiens_hsa005650.80843486
72Small cell lung cancer_Homo sapiens_hsa052220.78811281
73Focal adhesion_Homo sapiens_hsa045100.78640955
74Peroxisome_Homo sapiens_hsa041460.78449893
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.78235742
76Vibrio cholerae infection_Homo sapiens_hsa051100.78041432
77ErbB signaling pathway_Homo sapiens_hsa040120.76879322
78Insulin resistance_Homo sapiens_hsa049310.75911638
79Mineral absorption_Homo sapiens_hsa049780.75273560
80mTOR signaling pathway_Homo sapiens_hsa041500.75093265
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74505587
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74439117
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69780418
84VEGF signaling pathway_Homo sapiens_hsa043700.69176233
85Thyroid cancer_Homo sapiens_hsa052160.68507447
86Glioma_Homo sapiens_hsa052140.67960069
87Fructose and mannose metabolism_Homo sapiens_hsa000510.67921524
88Vitamin digestion and absorption_Homo sapiens_hsa049770.67903131
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67720569
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66620983
91Estrogen signaling pathway_Homo sapiens_hsa049150.65383719
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.64795890
93Glycerolipid metabolism_Homo sapiens_hsa005610.64681508
94Chronic myeloid leukemia_Homo sapiens_hsa052200.63976893
95Axon guidance_Homo sapiens_hsa043600.62221607
96Toxoplasmosis_Homo sapiens_hsa051450.61560507
97Long-term depression_Homo sapiens_hsa047300.61088357
98Melanogenesis_Homo sapiens_hsa049160.60485798
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60029551
100Galactose metabolism_Homo sapiens_hsa000520.59663843
101Dilated cardiomyopathy_Homo sapiens_hsa054140.59031825
102Starch and sucrose metabolism_Homo sapiens_hsa005000.58429084
103Pathways in cancer_Homo sapiens_hsa052000.58220078
104Propanoate metabolism_Homo sapiens_hsa006400.58076081
105Butanoate metabolism_Homo sapiens_hsa006500.56956272
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.55887670
107Pancreatic cancer_Homo sapiens_hsa052120.54907192
108Type II diabetes mellitus_Homo sapiens_hsa049300.54686981
109Ras signaling pathway_Homo sapiens_hsa040140.54322956
110Hepatitis C_Homo sapiens_hsa051600.53928799
111Prostate cancer_Homo sapiens_hsa052150.53611240
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53126592
113MicroRNAs in cancer_Homo sapiens_hsa052060.50614204
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50187454
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.49759760
116Pertussis_Homo sapiens_hsa051330.49434975
117Pancreatic secretion_Homo sapiens_hsa049720.48793529
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46833585
119Dorso-ventral axis formation_Homo sapiens_hsa043200.45165403
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44453861
121GnRH signaling pathway_Homo sapiens_hsa049120.43201712
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43087076
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42547628
124Selenocompound metabolism_Homo sapiens_hsa004500.41455768
125Acute myeloid leukemia_Homo sapiens_hsa052210.41174062
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.39943087
127Endometrial cancer_Homo sapiens_hsa052130.39047441
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37182493
129Lysine degradation_Homo sapiens_hsa003100.34519684
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31592852
131Platelet activation_Homo sapiens_hsa046110.29900398
132Wnt signaling pathway_Homo sapiens_hsa043100.29763784
133Rap1 signaling pathway_Homo sapiens_hsa040150.29653018
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.29555636
135Renin secretion_Homo sapiens_hsa049240.29470223
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.27825252
137p53 signaling pathway_Homo sapiens_hsa041150.27774708
138Notch signaling pathway_Homo sapiens_hsa043300.26107503

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