PPM1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serine family amino acid catabolic process (GO:0009071)4.86140951
2protein targeting to Golgi (GO:0000042)4.43092208
3retrograde transport, vesicle recycling within Golgi (GO:0000301)4.35176656
4establishment of protein localization to Golgi (GO:0072600)4.33622605
5CDP-diacylglycerol metabolic process (GO:0046341)4.18379906
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14584633
7glycine metabolic process (GO:0006544)4.01255674
8vitamin transmembrane transport (GO:0035461)3.94794356
9CDP-diacylglycerol biosynthetic process (GO:0016024)3.93941028
10NADH metabolic process (GO:0006734)3.91611690
11cysteine metabolic process (GO:0006534)3.89156918
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.75477197
13negative regulation of inclusion body assembly (GO:0090084)3.66806687
14L-phenylalanine catabolic process (GO:0006559)3.66170206
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.66170206
16pantothenate metabolic process (GO:0015939)3.61567267
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.56396330
18L-phenylalanine metabolic process (GO:0006558)3.56396330
19serine family amino acid metabolic process (GO:0009069)3.53731054
20amino-acid betaine metabolic process (GO:0006577)3.50718408
21biotin metabolic process (GO:0006768)3.45088382
22fatty acid transmembrane transport (GO:1902001)3.41130180
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36757242
24carnitine shuttle (GO:0006853)3.35591488
25alpha-linolenic acid metabolic process (GO:0036109)3.35274091
26neurotransmitter catabolic process (GO:0042135)3.34044525
27histone H3-K9 demethylation (GO:0033169)3.32287556
28positive regulation of receptor recycling (GO:0001921)3.27387800
29fructose metabolic process (GO:0006000)3.23967388
30response to pheromone (GO:0019236)3.23238773
31regulation of synaptic vesicle exocytosis (GO:2000300)3.22818620
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.20034315
33folic acid metabolic process (GO:0046655)3.17889527
34purine nucleobase biosynthetic process (GO:0009113)3.11506117
35positive regulation of insulin receptor signaling pathway (GO:0046628)3.10417282
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07956362
37urea cycle (GO:0000050)3.07950507
38urea metabolic process (GO:0019627)3.07950507
39cellular response to ethanol (GO:0071361)3.07205385
402-oxoglutarate metabolic process (GO:0006103)3.06838425
41fatty acid homeostasis (GO:0055089)3.06248351
42lysine metabolic process (GO:0006553)3.05351119
43lysine catabolic process (GO:0006554)3.05351119
44aromatic amino acid family catabolic process (GO:0009074)3.05181515
45negative regulation of macroautophagy (GO:0016242)3.04821941
46sulfur amino acid catabolic process (GO:0000098)3.03896968
47negative regulation of fatty acid biosynthetic process (GO:0045717)3.01873230
48macroautophagy (GO:0016236)3.01856725
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99187509
50negative regulation of cell killing (GO:0031342)2.99187509
51regulation of B cell receptor signaling pathway (GO:0050855)2.98451648
52Golgi to endosome transport (GO:0006895)2.98092621
53homocysteine metabolic process (GO:0050667)2.95020498
54folic acid transport (GO:0015884)2.93721198
55alpha-amino acid catabolic process (GO:1901606)2.93252950
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92835131
57kynurenine metabolic process (GO:0070189)2.92619252
58cellular ketone body metabolic process (GO:0046950)2.91760517
59bile acid biosynthetic process (GO:0006699)2.90253601
60glutamate metabolic process (GO:0006536)2.88401680
61histone H3-K36 demethylation (GO:0070544)2.88255771
62serine family amino acid biosynthetic process (GO:0009070)2.87497069
63acrosome reaction (GO:0007340)2.86534721
64cellular response to epinephrine stimulus (GO:0071872)2.86499483
65negative regulation of neurotransmitter transport (GO:0051589)2.86430037
66microglial cell activation (GO:0001774)2.85773467
67acetyl-CoA metabolic process (GO:0006084)2.82675405
68nitrogen cycle metabolic process (GO:0071941)2.81761558
69cellular amino acid catabolic process (GO:0009063)2.80947766
70relaxation of cardiac muscle (GO:0055119)2.78687574
71sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77197097
72mitotic metaphase plate congression (GO:0007080)2.76427338
73autophagic vacuole assembly (GO:0000045)2.76411165
74regulation of triglyceride catabolic process (GO:0010896)2.76130879
75regulation of synaptic vesicle transport (GO:1902803)2.75895420
76aspartate family amino acid catabolic process (GO:0009068)2.74195155
77regulation of bile acid biosynthetic process (GO:0070857)2.73007377
78triglyceride homeostasis (GO:0070328)2.72580681
79acylglycerol homeostasis (GO:0055090)2.72580681
80bile acid metabolic process (GO:0008206)2.72457628
81aromatic amino acid family metabolic process (GO:0009072)2.72018326
82protein localization to Golgi apparatus (GO:0034067)2.70949627
83negative regulation of fibrinolysis (GO:0051918)2.70699947
84lung-associated mesenchyme development (GO:0060484)2.70129649
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69706444
86regulation of cholesterol homeostasis (GO:2000188)2.68382903
87alditol metabolic process (GO:0019400)2.67024397
88protein K11-linked deubiquitination (GO:0035871)2.66902460
89nerve growth factor signaling pathway (GO:0038180)2.65534473
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64653797
91triglyceride biosynthetic process (GO:0019432)2.64268567
92cytoplasmic mRNA processing body assembly (GO:0033962)2.64176330
93regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64046998
94neutral lipid catabolic process (GO:0046461)2.63286061
95acylglycerol catabolic process (GO:0046464)2.63286061
96vesicle transport along microtubule (GO:0047496)2.63158095
97regulation of sequestering of triglyceride (GO:0010889)2.62752050
98carnitine transmembrane transport (GO:1902603)2.62275852
99positive regulation of Rap GTPase activity (GO:0032854)2.62188474
100regulation of ARF protein signal transduction (GO:0032012)2.61539340
101regulation of clathrin-mediated endocytosis (GO:2000369)2.60621272
102heme transport (GO:0015886)2.60196689
103negative regulation of neurotransmitter secretion (GO:0046929)2.59953295
104S-adenosylmethionine metabolic process (GO:0046500)2.59509466
105regulation of protein activation cascade (GO:2000257)2.59192234
106cerebellar Purkinje cell differentiation (GO:0021702)2.58102032
107neuromuscular process controlling posture (GO:0050884)2.57824580
108positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57373134
109positive regulation of lipid catabolic process (GO:0050996)2.57221960
110labyrinthine layer development (GO:0060711)2.56414538
111carnitine transport (GO:0015879)2.56279756
112amino-acid betaine transport (GO:0015838)2.56279756
113regulation of acyl-CoA biosynthetic process (GO:0050812)2.55898187
114positive regulation of gamma-delta T cell activation (GO:0046645)2.55784600
115dicarboxylic acid catabolic process (GO:0043649)2.55659254
116regulation of translational termination (GO:0006449)2.55344627
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.54731362
118interkinetic nuclear migration (GO:0022027)2.54490907
119acylglycerol biosynthetic process (GO:0046463)2.54073119
120neutral lipid biosynthetic process (GO:0046460)2.54073119
121negative regulation of potassium ion transmembrane transport (GO:1901380)2.53896266
122ventricular cardiac muscle cell action potential (GO:0086005)2.53473492
123dicarboxylic acid biosynthetic process (GO:0043650)2.52867867
124triglyceride catabolic process (GO:0019433)2.52026370
125regulation of relaxation of muscle (GO:1901077)2.50002399
126negative regulation of cAMP-mediated signaling (GO:0043951)2.49957870
127skeletal muscle adaptation (GO:0043501)2.48787454
128negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48107510
129hepatocyte apoptotic process (GO:0097284)2.47807445
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47645535
131ketone body metabolic process (GO:1902224)2.47152669
132regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.46582186
133indole-containing compound catabolic process (GO:0042436)2.46142608
134indolalkylamine catabolic process (GO:0046218)2.46142608
135tryptophan catabolic process (GO:0006569)2.46142608
136intestinal epithelial cell development (GO:0060576)2.46012563
137response to epinephrine (GO:0071871)2.45565927
138organic acid catabolic process (GO:0016054)2.45519278
139carboxylic acid catabolic process (GO:0046395)2.45519278
140glyoxylate metabolic process (GO:0046487)2.45329778
141glutamine family amino acid catabolic process (GO:0009065)2.45296297
142high-density lipoprotein particle remodeling (GO:0034375)2.44868453
143regulation of complement activation (GO:0030449)2.44643464
144regulation of protein glycosylation (GO:0060049)2.44634217
145complement activation, alternative pathway (GO:0006957)2.44129102
146peptidyl-threonine phosphorylation (GO:0018107)2.44011979
147synaptic vesicle maturation (GO:0016188)2.43727543
148regulation of sodium ion transmembrane transporter activity (GO:2000649)2.43644318
149regulation of Rap GTPase activity (GO:0032317)2.41895419
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41592476
151early endosome to late endosome transport (GO:0045022)2.39890766
152histone lysine demethylation (GO:0070076)2.39842280
153locomotory exploration behavior (GO:0035641)2.39283507
154synaptic vesicle docking involved in exocytosis (GO:0016081)2.39142069
155regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39001510
156detection of molecule of bacterial origin (GO:0032490)2.36583945
157negative regulation of dendrite morphogenesis (GO:0050774)2.35639160
158B cell receptor signaling pathway (GO:0050853)2.34955215
159regulation of gamma-delta T cell activation (GO:0046643)2.34256499
160regulation of beta-amyloid formation (GO:1902003)2.33709974
161potassium ion import (GO:0010107)2.32511082
162macrophage activation (GO:0042116)2.32398157
163macrophage activation involved in immune response (GO:0002281)2.31670325
164regulation of gamma-delta T cell differentiation (GO:0045586)2.31435917
165regulation of receptor recycling (GO:0001919)2.30009920
166positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.29881463
167histone demethylation (GO:0016577)2.29194232
168myofibril assembly (GO:0030239)2.28538984
169regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27517664
170cellular response to monoamine stimulus (GO:0071868)2.27486033
171cellular response to catecholamine stimulus (GO:0071870)2.27486033
172regulation of Rac protein signal transduction (GO:0035020)2.26120674
173striated muscle atrophy (GO:0014891)2.23810273
174positive regulation of fibroblast migration (GO:0010763)2.23063502
175cardiac muscle hypertrophy (GO:0003300)2.22006707
176calcium ion-dependent exocytosis (GO:0017156)2.21578883
177nucleus localization (GO:0051647)2.20027267
178phosphatidylinositol dephosphorylation (GO:0046856)2.19957976
179peptidyl-threonine modification (GO:0018210)2.19430964
180positive regulation of cellular amide metabolic process (GO:0034250)2.19200678
181positive regulation of cellular response to insulin stimulus (GO:1900078)2.19160782
182positive regulation of granulocyte differentiation (GO:0030854)2.19081407
183negative regulation of protein oligomerization (GO:0032460)2.18158851
184cerebellar granule cell differentiation (GO:0021707)2.17945540
185regulation of platelet aggregation (GO:0090330)2.17153395
186phospholipid dephosphorylation (GO:0046839)2.16992939
187intra-Golgi vesicle-mediated transport (GO:0006891)2.16801541
188relaxation of muscle (GO:0090075)2.15576736
189sodium ion export (GO:0071436)2.15437649
190regulation of Rab GTPase activity (GO:0032313)2.13858246
191positive regulation of Rab GTPase activity (GO:0032851)2.13858246
192positive regulation of glycolytic process (GO:0045821)2.13031641
193response to catecholamine (GO:0071869)2.10429478
194response to monoamine (GO:0071867)2.10429478
195monoubiquitinated protein deubiquitination (GO:0035520)2.09061595
196regulation of cAMP-dependent protein kinase activity (GO:2000479)2.09058199
197striated muscle hypertrophy (GO:0014897)2.08559057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.58643853
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.34969310
3ZNF263_19887448_ChIP-Seq_K562_Human4.65165096
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.88776817
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.67501522
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.32585383
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.17931124
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05025467
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.73968147
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.63899707
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.63158194
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.48149502
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45658488
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.35800716
15GATA1_22025678_ChIP-Seq_K562_Human2.31456241
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23381420
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19615134
18GBX2_23144817_ChIP-Seq_PC3_Human2.14485170
19* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10722670
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00918482
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89965239
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82202476
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81930228
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78874008
25RUNX_20019798_ChIP-Seq_JUKART_Human1.72626464
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70216005
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68227438
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66022485
29CLOCK_20551151_ChIP-Seq_293T_Human1.61225459
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61145280
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.60320958
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.59262917
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58094172
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56896357
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.56605695
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52798465
37SMAD4_21799915_ChIP-Seq_A2780_Human1.51413991
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49021843
39AR_21909140_ChIP-Seq_LNCAP_Human1.48495732
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47062053
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.46704415
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.45974506
43* ER_23166858_ChIP-Seq_MCF-7_Human1.45534726
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43933148
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.42066786
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41624899
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41189499
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41189499
49* STAT3_23295773_ChIP-Seq_U87_Human1.41015531
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39754199
51* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37842214
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37723447
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.37496080
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36875055
55REST_21632747_ChIP-Seq_MESCs_Mouse1.35979422
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35109415
57ZNF274_21170338_ChIP-Seq_K562_Hela1.33100885
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.31986737
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31392062
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30113326
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.28977408
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.28108794
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27520645
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27440825
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27391200
66P300_19829295_ChIP-Seq_ESCs_Human1.26840461
67TCF4_23295773_ChIP-Seq_U87_Human1.25966316
68AHR_22903824_ChIP-Seq_MCF-7_Human1.25606458
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24934205
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24839880
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24793955
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24547889
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.24430676
74VDR_24787735_ChIP-Seq_THP-1_Human1.24076270
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23676359
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.22729867
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22689658
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21381662
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21317812
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20747281
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.20567703
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.19454161
83FUS_26573619_Chip-Seq_HEK293_Human1.18260922
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17696045
85GATA2_19941826_ChIP-Seq_K562_Human1.17617089
86* FLI1_21867929_ChIP-Seq_TH2_Mouse1.17219481
87AR_25329375_ChIP-Seq_VCAP_Human1.17085535
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16971937
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.16812424
90SCL_19346495_ChIP-Seq_HPC-7_Human1.16664298
91TP53_16413492_ChIP-PET_HCT116_Human1.16341902
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.15955602
93DROSHA_22980978_ChIP-Seq_HELA_Human1.15948080
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15884562
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15051780
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14936149
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14415840
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.14064221
99* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13817071
100* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12765940
101CBP_20019798_ChIP-Seq_JUKART_Human1.12732834
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12732834
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12643303
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12421115
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12133235
106GATA1_19941826_ChIP-Seq_K562_Human1.10995684
107FOXA2_19822575_ChIP-Seq_HepG2_Human1.09883295
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09771271
109* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09083594
110KLF4_19829295_ChIP-Seq_ESCs_Human1.08089780
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07649902
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.07113837
113AR_21572438_ChIP-Seq_LNCaP_Human1.06778379
114P53_22387025_ChIP-Seq_ESCs_Mouse1.05864377
115* CREB1_26743006_Chip-Seq_LNCaP_Human1.04706378
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04705941
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04319544
118KDM2B_26808549_Chip-Seq_REH_Human1.03800462
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03629930
120PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03289171
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02334402
122GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01080563
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00789859
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00690318
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00426167
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.00184779
127CDX2_22108803_ChIP-Seq_LS180_Human1.00175112
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.99397926
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99253041
130* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99034203
131SMRT_27268052_Chip-Seq_Bcells_Human0.98242028
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.98235147
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97711830
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97546453
135KDM2B_26808549_Chip-Seq_K562_Human0.97487928
136* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97436159
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97381778
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97298965
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95969795
140* ATF3_27146783_Chip-Seq_COLON_Human0.95591703
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94897812
142OCT4_19829295_ChIP-Seq_ESCs_Human0.93439802
143* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93165257
144HNF4A_19822575_ChIP-Seq_HepG2_Human0.92714567
145CTCF_27219007_Chip-Seq_Bcells_Human0.92354055
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91880061
147EOMES_21245162_ChIP-Seq_HESCs_Human0.88798401
148FOXH1_21741376_ChIP-Seq_ESCs_Human0.87694516
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87528340
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87464661
151* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85476350
152* NANOG_16518401_ChIP-PET_MESCs_Mouse0.83144918
153* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81401936
154EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81017987
155CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80964725
156* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80755915
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77722849
158FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75140200
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.73920078
160EZH2_22144423_ChIP-Seq_EOC_Human0.73786160
161NANOG_18692474_ChIP-Seq_MESCs_Mouse0.72992500
162SOX2_21211035_ChIP-Seq_LN229_Human0.72799976
163* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72300830
164NANOG_18692474_ChIP-Seq_MEFs_Mouse0.71830554
165FOXO3_23340844_ChIP-Seq_DLD1_Human0.71705561
166* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71288389
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.69093223
168* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68583062
169* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.68494254
170RUNX1_27514584_Chip-Seq_MCF-7_Human0.68013779
171SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67960035
172CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67945792
173FOXM1_23109430_ChIP-Seq_U2OS_Human0.67249886
174TBL1_22424771_ChIP-Seq_293T_Human0.66639350
175* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.66401829
176RACK7_27058665_Chip-Seq_MCF-7_Human0.65788817
177CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.65683680
178TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.65059718
179* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.64965775
180PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64833913
181* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.64813217
182CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.64634090
183SMC4_20622854_ChIP-Seq_HELA_Human0.64421930
184RXR_22108803_ChIP-Seq_LS180_Human0.64158623
185SOX2_21211035_ChIP-Seq_LN229_Gbm0.64155679
186TCF3_18692474_ChIP-Seq_MEFs_Mouse0.63391828
187ERA_21632823_ChIP-Seq_H3396_Human0.63196651
188CTBP2_25329375_ChIP-Seq_LNCAP_Human0.63083219
189SOX2_18692474_ChIP-Seq_MESCs_Mouse0.62938676
190TAF15_26573619_Chip-Seq_HEK293_Human0.61993206
191SOX2_18692474_ChIP-Seq_MEFs_Mouse0.61918542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.86198139
2MP0005360_urolithiasis3.58082125
3MP0005085_abnormal_gallbladder_physiolo3.57863657
4MP0000569_abnormal_digit_pigmentation3.32957874
5MP0005365_abnormal_bile_salt3.20420854
6MP0003787_abnormal_imprinting2.69665605
7MP0008057_abnormal_DNA_replication2.58492668
8MP0004859_abnormal_synaptic_plasticity2.58392001
9MP0002837_dystrophic_cardiac_calcinosis2.57891004
10MP0003646_muscle_fatigue2.50891252
11MP0004510_myositis2.38127506
12MP0009840_abnormal_foam_cell2.36792066
13MP0010329_abnormal_lipoprotein_level2.35060276
14MP0008875_abnormal_xenobiotic_pharmacok2.29630487
15MP0004130_abnormal_muscle_cell2.18152142
16MP0003806_abnormal_nucleotide_metabolis2.08396536
17MP0004145_abnormal_muscle_electrophysio2.01592681
18MP0005451_abnormal_body_composition2.00480137
19MP0004270_analgesia2.00185755
20MP0002166_altered_tumor_susceptibility1.98550420
21MP0005332_abnormal_amino_acid1.97481145
22MP0000747_muscle_weakness1.92573483
23MP0008877_abnormal_DNA_methylation1.90568065
24MP0000751_myopathy1.89313871
25MP0003329_amyloid_beta_deposits1.85896451
26MP0003303_peritoneal_inflammation1.75986755
27MP0005666_abnormal_adipose_tissue1.74027088
28MP0003718_maternal_effect1.73525177
29MP0004185_abnormal_adipocyte_glucose1.71116849
30MP0005464_abnormal_platelet_physiology1.69865077
31MP0003724_increased_susceptibility_to1.68760290
32MP0003172_abnormal_lysosome_physiology1.64473255
33MP0008260_abnormal_autophagy1.64420998
34MP0005310_abnormal_salivary_gland1.62442185
35MP0003635_abnormal_synaptic_transmissio1.61831527
36MP0004036_abnormal_muscle_relaxation1.58227229
37MP0002118_abnormal_lipid_homeostasis1.57847802
38MP0003045_fibrosis1.55627844
39MP0002269_muscular_atrophy1.51726780
40MP0005330_cardiomyopathy1.51630033
41MP0003705_abnormal_hypodermis_morpholog1.49742972
42MP0003300_gastrointestinal_ulcer1.49505704
43MP0002822_catalepsy1.47551928
44MP0001440_abnormal_grooming_behavior1.45820762
45MP0003828_pulmonary_edema1.45515310
46MP0003183_abnormal_peptide_metabolism1.44658111
47MP0003221_abnormal_cardiomyocyte_apopto1.43108155
48MP0004084_abnormal_cardiac_muscle1.42485254
49MP0009046_muscle_twitch1.38800012
50MP0003880_abnormal_central_pattern1.37732966
51MP0000750_abnormal_muscle_regeneration1.33103529
52MP0002009_preneoplasia1.31194951
53MP0006036_abnormal_mitochondrial_physio1.30190680
54MP0001661_extended_life_span1.28936545
55MP0008569_lethality_at_weaning1.28611075
56MP0002971_abnormal_brown_adipose1.27960951
57MP0003252_abnormal_bile_duct1.27789333
58MP0001835_abnormal_antigen_presentation1.27767297
59MP0010234_abnormal_vibrissa_follicle1.25386287
60MP0004215_abnormal_myocardial_fiber1.24240810
61MP0004019_abnormal_vitamin_homeostasis1.24121293
62MP0002064_seizures1.21779082
63MP0003633_abnormal_nervous_system1.19918075
64MP0004087_abnormal_muscle_fiber1.19599531
65MP0000609_abnormal_liver_physiology1.18577687
66MP0004885_abnormal_endolymph1.18123484
67MP0002063_abnormal_learning/memory/cond1.17826583
68MP0005379_endocrine/exocrine_gland_phen1.15671320
69MP0005423_abnormal_somatic_nervous1.15179625
70MP0005670_abnormal_white_adipose1.15071789
71MP0000015_abnormal_ear_pigmentation1.13060201
72MP0002734_abnormal_mechanical_nocicepti1.11449406
73MP0002006_tumorigenesis1.10991934
74MP0005375_adipose_tissue_phenotype1.10842502
75MP0004381_abnormal_hair_follicle1.09913745
76MP0006035_abnormal_mitochondrial_morpho1.09380992
77MP0002909_abnormal_adrenal_gland1.09207919
78MP0001348_abnormal_lacrimal_gland1.06777133
79MP0003191_abnormal_cellular_cholesterol1.06318187
80MP0000604_amyloidosis1.05949456
81MP0005083_abnormal_biliary_tract1.05393666
82MP0003195_calcinosis1.05002006
83MP0005620_abnormal_muscle_contractility1.03910893
84MP0002106_abnormal_muscle_physiology1.03084321
85MP0001666_abnormal_nutrient_absorption1.02728329
86MP0009745_abnormal_behavioral_response1.01598881
87MP0001765_abnormal_ion_homeostasis1.01338113
88MP0003631_nervous_system_phenotype1.01306385
89MP0002796_impaired_skin_barrier1.00841798
90MP0001501_abnormal_sleep_pattern1.00719717
91MP0010352_gastrointestinal_tract_polyps1.00164071
92MP0002972_abnormal_cardiac_muscle0.99688421
93MP0005535_abnormal_body_temperature0.99664110
94MP0005410_abnormal_fertilization0.99458158
95MP0002067_abnormal_sensory_capabilities0.99421927
96MP0005319_abnormal_enzyme/_coenzyme0.98866763
97MP0009672_abnormal_birth_weight0.98622896
98MP0002928_abnormal_bile_duct0.98288272
99MP0008874_decreased_physiological_sensi0.97765449
100MP0005409_darkened_coat_color0.97297935
101MP0003091_abnormal_cell_migration0.96083728
102MP0001486_abnormal_startle_reflex0.95988154
103MP0004233_abnormal_muscle_weight0.95965824
104MP0006138_congestive_heart_failure0.95191125
105MP0003690_abnormal_glial_cell0.95147876
106MP0005248_abnormal_Harderian_gland0.93638697
107MP0003763_abnormal_thymus_physiology0.93199702
108MP0003868_abnormal_feces_composition0.91355183
109MP0001730_embryonic_growth_arrest0.89232230
110MP0003879_abnormal_hair_cell0.86842815
111MP0000759_abnormal_skeletal_muscle0.86142586
112MP0005395_other_phenotype0.85871801
113MP0002693_abnormal_pancreas_physiology0.85349892
114MP0005187_abnormal_penis_morphology0.85174283
115MP0003698_abnormal_male_reproductive0.84869192
116MP0002272_abnormal_nervous_system0.84075567
117MP0009780_abnormal_chondrocyte_physiolo0.83968931
118MP0005369_muscle_phenotype0.83511665
119MP0005386_behavior/neurological_phenoty0.82550887
120MP0004924_abnormal_behavior0.82550887
121MP0003866_abnormal_defecation0.81843238
122MP0000427_abnormal_hair_cycle0.81483589
123MP0001800_abnormal_humoral_immune0.80969856
124MP0000685_abnormal_immune_system0.80848710
125MP0009115_abnormal_fat_cell0.80411299
126MP0002735_abnormal_chemical_nociception0.80322485
127MP0002733_abnormal_thermal_nociception0.79009743
128MP0003137_abnormal_impulse_conducting0.78433096
129MP0003111_abnormal_nucleus_morphology0.78249659
130MP0003693_abnormal_embryo_hatching0.77951464
131MP0001851_eye_inflammation0.77459276
132MP0004883_abnormal_blood_vessel0.77205218
133MP0005584_abnormal_enzyme/coenzyme_acti0.76965425
134MP0004147_increased_porphyrin_level0.76609835
135MP0003632_abnormal_nervous_system0.76350340
136MP0005334_abnormal_fat_pad0.75750056
137MP0002572_abnormal_emotion/affect_behav0.74207320
138MP0002229_neurodegeneration0.73924617
139MP0002066_abnormal_motor_capabilities/c0.73646605
140MP0001764_abnormal_homeostasis0.73524199
141MP0000749_muscle_degeneration0.73047910
142MP0010678_abnormal_skin_adnexa0.72435051
143MP0002127_abnormal_cardiovascular_syste0.72358975
144MP0002078_abnormal_glucose_homeostasis0.71972733
145MP0004484_altered_response_of0.71572111
146MP0004085_abnormal_heartbeat0.68585144
147MP0003656_abnormal_erythrocyte_physiolo0.68333175
148MP0002332_abnormal_exercise_endurance0.67946629
149MP0004858_abnormal_nervous_system0.66676290
150MP0003123_paternal_imprinting0.65463274
151MP0005266_abnormal_metabolism0.65365435

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)5.54148827
2Hyperglycinuria (HP:0003108)4.96307660
3Abnormality of glycine metabolism (HP:0010895)4.51614754
4Abnormality of serine family amino acid metabolism (HP:0010894)4.51614754
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.32789277
6Papillary thyroid carcinoma (HP:0002895)4.24280633
7Muscle fiber splitting (HP:0003555)3.93969995
8Bundle branch block (HP:0011710)3.73199556
9Gout (HP:0001997)3.71062343
10Febrile seizures (HP:0002373)3.67094646
11Atrioventricular block (HP:0001678)3.64887383
12Ventricular fibrillation (HP:0001663)3.61579086
13Abnormality of the left ventricular outflow tract (HP:0011103)3.50388072
14Subaortic stenosis (HP:0001682)3.50388072
15Deep venous thrombosis (HP:0002625)3.43227619
16Xanthomatosis (HP:0000991)3.37968749
17Hyperlipoproteinemia (HP:0010980)3.30664833
18Hyperkalemia (HP:0002153)3.21412606
19Abnormality of serum amino acid levels (HP:0003112)3.19865463
20Nemaline bodies (HP:0003798)3.14962634
21Hypobetalipoproteinemia (HP:0003563)3.07553891
22Intrahepatic cholestasis (HP:0001406)3.07332242
23Focal motor seizures (HP:0011153)3.04111263
24Calf muscle hypertrophy (HP:0008981)2.97718004
25Exercise-induced myalgia (HP:0003738)2.95234775
26Hypoalphalipoproteinemia (HP:0003233)2.95097246
27Abnormality of the Achilles tendon (HP:0005109)2.93773562
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86979574
29Hypolipoproteinemia (HP:0010981)2.86133966
30Global brain atrophy (HP:0002283)2.84220747
31Abnormality of the lower motor neuron (HP:0002366)2.82810868
32Heart block (HP:0012722)2.81094119
33Myokymia (HP:0002411)2.78884138
34Thyroid carcinoma (HP:0002890)2.78576056
35Achilles tendon contracture (HP:0001771)2.73460314
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73137026
37Poikilocytosis (HP:0004447)2.72505379
38Abnormal atrioventricular conduction (HP:0005150)2.69944932
39Atonic seizures (HP:0010819)2.69365397
40Hypochromic microcytic anemia (HP:0004840)2.68645368
41Resting tremor (HP:0002322)2.66651922
42Tetraplegia (HP:0002445)2.66395878
43Areflexia of lower limbs (HP:0002522)2.65220649
44Hyperglycemia (HP:0003074)2.62435734
45Hyperammonemia (HP:0001987)2.61333268
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61116723
47Difficulty climbing stairs (HP:0003551)2.60330993
48Papilledema (HP:0001085)2.59588166
49Prolonged bleeding time (HP:0003010)2.59233762
50Testicular neoplasm (HP:0010788)2.57267133
51Progressive cerebellar ataxia (HP:0002073)2.56982366
52Hyporeflexia of lower limbs (HP:0002600)2.54495953
53Gingival bleeding (HP:0000225)2.53204738
54Truncal obesity (HP:0001956)2.52256838
55Menstrual irregularities (HP:0000858)2.50281946
56Insidious onset (HP:0003587)2.45871205
57Termporal pattern (HP:0011008)2.45871205
58Neoplasm of the tracheobronchial system (HP:0100552)2.45706746
59Slow saccadic eye movements (HP:0000514)2.43568225
60Hyperuricemia (HP:0002149)2.43011165
61Increased purine levels (HP:0004368)2.43011165
62Delusions (HP:0000746)2.42146081
63Shoulder girdle muscle weakness (HP:0003547)2.40709285
64Mutism (HP:0002300)2.36524339
65Fetal akinesia sequence (HP:0001989)2.35327958
66Eczematoid dermatitis (HP:0000976)2.35172494
67Focal seizures (HP:0007359)2.33742305
68Sudden death (HP:0001699)2.29360481
69Ketosis (HP:0001946)2.28630302
70Frequent falls (HP:0002359)2.26628593
71EMG: myopathic abnormalities (HP:0003458)2.26378889
72Male infertility (HP:0003251)2.23323489
73Exercise-induced muscle cramps (HP:0003710)2.20058561
74Visual hallucinations (HP:0002367)2.19588322
75Epidermoid cyst (HP:0200040)2.19327858
76Pelvic girdle muscle weakness (HP:0003749)2.18269692
77Recurrent bacterial skin infections (HP:0005406)2.18210687
78Dysmetric saccades (HP:0000641)2.17823041
79T lymphocytopenia (HP:0005403)2.17756085
80Cerebral hypomyelination (HP:0006808)2.17497769
81Asymmetric septal hypertrophy (HP:0001670)2.17306730
82Multiple enchondromatosis (HP:0005701)2.13812633
83Gaze-evoked nystagmus (HP:0000640)2.13207271
84Gingivitis (HP:0000230)2.11313592
85Spontaneous hematomas (HP:0007420)2.10834064
86Difficulty running (HP:0009046)2.10803688
87Cerebral inclusion bodies (HP:0100314)2.06551946
88Spastic tetraparesis (HP:0001285)2.06241933
89Complement deficiency (HP:0004431)2.05976374
90Syncope (HP:0001279)2.05868658
91Genetic anticipation (HP:0003743)2.05385194
92Impulsivity (HP:0100710)2.04874151
93Acanthocytosis (HP:0001927)2.04601149
94Hypoplastic ischia (HP:0003175)2.00927157
95Lethargy (HP:0001254)1.99671941
96Impaired social interactions (HP:0000735)1.98853589
97Abnormal social behavior (HP:0012433)1.98853589
98Muscle fiber inclusion bodies (HP:0100299)1.98842000
99Abnormality of T cell number (HP:0011839)1.98624977
100Urinary bladder sphincter dysfunction (HP:0002839)1.97694357
101Abnormality of the fingertips (HP:0001211)1.97633234
102Abnormality of the musculature of the pelvis (HP:0001469)1.96225333
103Abnormality of the hip-girdle musculature (HP:0001445)1.96225333
104Morphological abnormality of the pyramidal tract (HP:0002062)1.95569264
105Progressive muscle weakness (HP:0003323)1.95039503
106Type 1 muscle fiber predominance (HP:0003803)1.94188216
107Abnormal cartilage morphology (HP:0002763)1.94104723
108Alveolar cell carcinoma (HP:0006519)1.93554399
109Status epilepticus (HP:0002133)1.93467803
110Ventricular arrhythmia (HP:0004308)1.92628832
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92406244
112Abnormality of potassium homeostasis (HP:0011042)1.92124697
113Biliary tract neoplasm (HP:0100574)1.92007743
114Increased connective tissue (HP:0009025)1.91201214
115Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90330100
116Ankle clonus (HP:0011448)1.89818253
117Generalized tonic-clonic seizures (HP:0002069)1.89208047
118Generalized hypopigmentation of hair (HP:0011358)1.89164194
119Abnormality of the ischium (HP:0003174)1.87988836
120Germ cell neoplasia (HP:0100728)1.87905736
121Abnormality of the labia minora (HP:0012880)1.87602424
122Gastrointestinal infarctions (HP:0005244)1.87573067
123Muscle hypertrophy of the lower extremities (HP:0008968)1.86939200
124Pheochromocytoma (HP:0002666)1.85863056
125Insulin-resistant diabetes mellitus (HP:0000831)1.85477557
126Microcytic anemia (HP:0001935)1.85359567
127Subacute progressive viral hepatitis (HP:0006572)1.84184097
128Abnormality of fatty-acid metabolism (HP:0004359)1.83901778
129Volvulus (HP:0002580)1.83210601
130Abnormality of chloride homeostasis (HP:0011422)1.82532357
131Restlessness (HP:0000711)1.82222155
132Action tremor (HP:0002345)1.81485452
133Abnormality of purine metabolism (HP:0004352)1.81446214
134Prolonged partial thromboplastin time (HP:0003645)1.80748305
135Abnormal platelet volume (HP:0011876)1.80678436
136Increased mean platelet volume (HP:0011877)1.80676588
137Thyroiditis (HP:0100646)1.80511388
138Fair hair (HP:0002286)1.80233901
139Myoglobinuria (HP:0002913)1.79681305
140Irritability (HP:0000737)1.79513250
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.79234338
142Abnormality of the calf musculature (HP:0001430)1.79227454
143Absence seizures (HP:0002121)1.78088048
144Impaired vibratory sensation (HP:0002495)1.75829349
145Childhood onset (HP:0011463)1.74579031
146Postural instability (HP:0002172)1.73221838
147Cholelithiasis (HP:0001081)1.72522948
148Recurrent abscess formation (HP:0002722)1.72496064
149Abnormality of saccadic eye movements (HP:0000570)1.72396743
150Testicular atrophy (HP:0000029)1.71776952
151Cystic hygroma (HP:0000476)1.71648197
152Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71546976
153Impaired vibration sensation in the lower limbs (HP:0002166)1.70583802
154EMG: neuropathic changes (HP:0003445)1.70502346
155Polycythemia (HP:0001901)1.70403087
156Neurofibrillary tangles (HP:0002185)1.70352460
157Urinary urgency (HP:0000012)1.69028419
158Transitional cell carcinoma of the bladder (HP:0006740)1.68201711
159Increased circulating renin level (HP:0000848)1.67843005
160Oligomenorrhea (HP:0000876)1.67654700
161Rhabdomyolysis (HP:0003201)1.67549444
162Rimmed vacuoles (HP:0003805)1.67504871
163Dialeptic seizures (HP:0011146)1.67454961
164Ventricular tachycardia (HP:0004756)1.66480966
165Ureteral duplication (HP:0000073)1.66380157
166Myotonia (HP:0002486)1.66375127
167Epistaxis (HP:0000421)1.66228926
168Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65925187
169Chest pain (HP:0100749)1.65570002
170Curly hair (HP:0002212)1.65059558
171Retrobulbar optic neuritis (HP:0100654)1.64642346
172Optic neuritis (HP:0100653)1.64642346
173Hyperventilation (HP:0002883)1.64463260
174Epileptic encephalopathy (HP:0200134)1.63143688
175Bladder neoplasm (HP:0009725)1.62927313
176Bladder carcinoma (HP:0002862)1.62927313
177Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58770858
178Degeneration of the lateral corticospinal tracts (HP:0002314)1.58770858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS23.42972828
2FRK3.41942065
3PNCK3.34183635
4MAP3K93.17006748
5PDK33.15823548
6PDK43.15823548
7RIPK42.59942752
8SGK22.41110132
9NEK12.40275379
10PINK12.35324277
11AKT32.21463459
12PDK22.21020704
13PIK3CG2.19107385
14EPHA42.17244663
15WEE12.16986535
16KSR21.91551244
17FGFR31.89805706
18MAP2K41.85996432
19LATS11.85685391
20PAK61.83390844
21PLK21.82755486
22ALK1.81539869
23BCKDK1.79094995
24WNK11.77319706
25PHKG21.76687249
26PHKG11.76687249
27ARAF1.74957596
28STK381.71665388
29TRIB31.67116785
30SGK2231.66310978
31SGK4941.66310978
32PRKD31.65325966
33MARK11.65305450
34ACVR1B1.56741377
35BRD41.55680360
36FES1.52549103
37MAP3K41.52519692
38TRPM71.45104925
39PTK2B1.39373380
40BMPR21.38563983
41NLK1.35874420
42CAMK1G1.31020235
43TSSK61.29768895
44STK38L1.27499941
45MAP2K31.21310777
46NTRK31.20805465
47LMTK21.20285772
48NTRK11.19509802
49GRK51.16511958
50CAMKK21.16394003
51TYRO31.16240694
52DAPK21.12457855
53JAK11.12112661
54MAP3K11.11325132
55TAOK11.10873121
56MINK11.08898924
57PRKAA11.03682502
58MAP3K131.02879037
59STK31.00925291
60NEK21.00264812
61SGK10.99567110
62IKBKE0.98979275
63TTN0.97499234
64OBSCN0.97491467
65PRPF4B0.97092921
66ICK0.96082305
67CASK0.95914469
68FGR0.95631597
69YES10.94694663
70TAOK30.93906935
71STK110.90962238
72PDPK10.90716822
73BLK0.89774317
74BUB10.89546751
75MAP3K20.89124545
76NEK60.88456460
77SYK0.87823736
78PAK30.87770523
79PRKCG0.87448043
80CAMK10.87379480
81ERBB30.86157838
82UHMK10.85777745
83PLK30.84907983
84JAK20.84319033
85RAF10.83881372
86BRSK10.83384030
87GRK60.81586898
88CSNK1G20.81548066
89MAP3K60.80835581
90MAP3K70.78852651
91CSK0.77326891
92ABL20.76972284
93MARK20.76087884
94RET0.75661992
95PKN20.75606535
96DYRK1A0.75068993
97CSNK1E0.74531119
98TNIK0.74383406
99TTK0.73605279
100CAMK40.73564980
101IRAK10.73353799
102PIK3CA0.73338619
103EIF2AK10.71463911
104ERBB40.70700426
105PDK10.70597519
106DDR20.70582883
107CAMKK10.70083723
108KSR10.67550015
109FER0.67000528
110STK390.63055185
111STK40.62838483
112MAP3K50.62815795
113NME10.60297828
114BTK0.59904617
115CSNK1G10.59485898
116NTRK20.59019968
117STK240.58870926
118TEC0.58731274
119BRSK20.58569733
120HCK0.57534568
121MST40.57166870
122BRAF0.56939119
123MAP2K10.56874250
124HIPK20.56854216
125ERBB20.56283073
126PLK10.54530893
127CAMK2G0.54498944
128CDK50.54217447
129MELK0.52044740
130MAP3K140.51399308
131CSNK1G30.50882776
132RIPK10.50609183
133NEK90.50518799
134IRAK20.50488831
135MAP2K70.49404748
136MAPK100.49251305
137CDK120.49088794
138FGFR20.48944884
139TYK20.48102269
140PRKAA20.45892904
141RPS6KA30.45312875
142MAPK130.45243144
143CDK140.45198684
144PRKCZ0.44386985
145PRKG10.44263162
146IRAK40.43946489
147BMX0.43852087
148CDK150.40662539
149CAMK2A0.39681183
150PDGFRA0.38768869
151MTOR0.38622424
152GSK3A0.37541050
153DMPK0.37428658
154PRKACG0.37155203
155OXSR10.36669376
156AURKA0.35967494
157MAPK120.34968805
158SGK30.34804321
159CDK11A0.33196303
160CDK180.32084350
161CSNK1D0.29845942

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.67323586
2Nitrogen metabolism_Homo sapiens_hsa009103.54238726
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16186818
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91835058
5Arginine biosynthesis_Homo sapiens_hsa002202.64018694
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.62294894
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46532175
8Butanoate metabolism_Homo sapiens_hsa006502.24992746
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24991837
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.09903241
11Propanoate metabolism_Homo sapiens_hsa006402.08823588
12Fatty acid degradation_Homo sapiens_hsa000711.97042092
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94765318
14Phosphatidylinositol signaling system_Homo sapiens_hsa040701.79957374
15Fatty acid metabolism_Homo sapiens_hsa012121.75273463
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73725069
17PPAR signaling pathway_Homo sapiens_hsa033201.69057738
18Carbon metabolism_Homo sapiens_hsa012001.60030472
19B cell receptor signaling pathway_Homo sapiens_hsa046621.55282713
20Inositol phosphate metabolism_Homo sapiens_hsa005621.53848316
21Biosynthesis of amino acids_Homo sapiens_hsa012301.52643716
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51249864
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48559325
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47380615
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.46646011
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.45710447
27beta-Alanine metabolism_Homo sapiens_hsa004101.43288420
28Renin secretion_Homo sapiens_hsa049241.43287549
29Fatty acid biosynthesis_Homo sapiens_hsa000611.40318178
30Platelet activation_Homo sapiens_hsa046111.39545378
31Non-small cell lung cancer_Homo sapiens_hsa052231.36218368
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35517116
33Bile secretion_Homo sapiens_hsa049761.33762517
34Insulin secretion_Homo sapiens_hsa049111.31550813
35Tryptophan metabolism_Homo sapiens_hsa003801.29903801
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27122827
37FoxO signaling pathway_Homo sapiens_hsa040681.26088974
38Pentose phosphate pathway_Homo sapiens_hsa000301.24537470
39Endometrial cancer_Homo sapiens_hsa052131.22786665
40Regulation of autophagy_Homo sapiens_hsa041401.21767460
41Glycerolipid metabolism_Homo sapiens_hsa005611.20543394
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19481040
43Long-term depression_Homo sapiens_hsa047301.18255906
44Pyruvate metabolism_Homo sapiens_hsa006201.16788779
45Prolactin signaling pathway_Homo sapiens_hsa049171.15135761
46Cholinergic synapse_Homo sapiens_hsa047251.14381411
47T cell receptor signaling pathway_Homo sapiens_hsa046601.12990755
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11391103
49Glioma_Homo sapiens_hsa052141.10884448
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.10732233
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10229038
52Osteoclast differentiation_Homo sapiens_hsa043801.06810721
53Pancreatic secretion_Homo sapiens_hsa049721.04003569
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03834937
55ErbB signaling pathway_Homo sapiens_hsa040121.00731909
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.99852164
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98546541
58Complement and coagulation cascades_Homo sapiens_hsa046100.98258683
59Calcium signaling pathway_Homo sapiens_hsa040200.97661138
60Synaptic vesicle cycle_Homo sapiens_hsa047210.96801799
61Oocyte meiosis_Homo sapiens_hsa041140.96670102
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96222577
63VEGF signaling pathway_Homo sapiens_hsa043700.96187880
64cAMP signaling pathway_Homo sapiens_hsa040240.95235846
65Fat digestion and absorption_Homo sapiens_hsa049750.94189361
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.94060286
67Chemokine signaling pathway_Homo sapiens_hsa040620.92073939
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91544662
69Choline metabolism in cancer_Homo sapiens_hsa052310.90772893
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.90434883
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.90019489
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.88068336
73Peroxisome_Homo sapiens_hsa041460.87148427
74Morphine addiction_Homo sapiens_hsa050320.87052529
75Acute myeloid leukemia_Homo sapiens_hsa052210.86019166
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84365384
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84284454
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.83286398
79Vitamin digestion and absorption_Homo sapiens_hsa049770.83005102
80Phenylalanine metabolism_Homo sapiens_hsa003600.82898123
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81760462
82Folate biosynthesis_Homo sapiens_hsa007900.80883736
83Arginine and proline metabolism_Homo sapiens_hsa003300.80273318
84Pancreatic cancer_Homo sapiens_hsa052120.80143829
85ABC transporters_Homo sapiens_hsa020100.78781190
86AMPK signaling pathway_Homo sapiens_hsa041520.77995293
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.77172260
88Leishmaniasis_Homo sapiens_hsa051400.76234427
89Starch and sucrose metabolism_Homo sapiens_hsa005000.75342249
90mTOR signaling pathway_Homo sapiens_hsa041500.74795627
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74260912
92Glucagon signaling pathway_Homo sapiens_hsa049220.74126539
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71805097
94Retinol metabolism_Homo sapiens_hsa008300.71691151
95Fructose and mannose metabolism_Homo sapiens_hsa000510.71118540
96Serotonergic synapse_Homo sapiens_hsa047260.70840888
97Insulin signaling pathway_Homo sapiens_hsa049100.70206838
98Nicotine addiction_Homo sapiens_hsa050330.70110802
99GABAergic synapse_Homo sapiens_hsa047270.70106896
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70050384
101* MAPK signaling pathway_Homo sapiens_hsa040100.69848680
102Chronic myeloid leukemia_Homo sapiens_hsa052200.69814816
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69463821
104Prostate cancer_Homo sapiens_hsa052150.68369495
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67973576
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67794870
107Tuberculosis_Homo sapiens_hsa051520.67147722
108Taste transduction_Homo sapiens_hsa047420.66557268
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66233965
110Type I diabetes mellitus_Homo sapiens_hsa049400.65723109
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65502280
112Long-term potentiation_Homo sapiens_hsa047200.65013987
113Histidine metabolism_Homo sapiens_hsa003400.64467410
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64294571
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.63897397
116Dilated cardiomyopathy_Homo sapiens_hsa054140.63562756
117Measles_Homo sapiens_hsa051620.63514222
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62543081
119Gap junction_Homo sapiens_hsa045400.62351713
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.61235638
121Fatty acid elongation_Homo sapiens_hsa000620.61018353
122Circadian rhythm_Homo sapiens_hsa047100.60889302
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60730378
124Dorso-ventral axis formation_Homo sapiens_hsa043200.60254165
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60028237
126Amphetamine addiction_Homo sapiens_hsa050310.59511756
127Cardiac muscle contraction_Homo sapiens_hsa042600.58525997
128Olfactory transduction_Homo sapiens_hsa047400.58403780
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58238712
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57668302
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57268501
132Chemical carcinogenesis_Homo sapiens_hsa052040.56654160
133Tyrosine metabolism_Homo sapiens_hsa003500.56250823
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54371492
135Influenza A_Homo sapiens_hsa051640.53646945
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52637173
137Endocytosis_Homo sapiens_hsa041440.52216297
138Cocaine addiction_Homo sapiens_hsa050300.52120107
139Selenocompound metabolism_Homo sapiens_hsa004500.51560382
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.51045142
141Salivary secretion_Homo sapiens_hsa049700.46436863
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.45507704
143Insulin resistance_Homo sapiens_hsa049310.45336622
144RNA polymerase_Homo sapiens_hsa030200.45175885
145Estrogen signaling pathway_Homo sapiens_hsa049150.44976764
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43392168
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42243285
148Gastric acid secretion_Homo sapiens_hsa049710.40490226
149Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39954541
150Renal cell carcinoma_Homo sapiens_hsa052110.39028930
151Glutamatergic synapse_Homo sapiens_hsa047240.38385954
152Dopaminergic synapse_Homo sapiens_hsa047280.38102859
153Prion diseases_Homo sapiens_hsa050200.37758601
154Sulfur relay system_Homo sapiens_hsa041220.37050732
155RNA transport_Homo sapiens_hsa030130.36965776
156GnRH signaling pathway_Homo sapiens_hsa049120.36586443
157Type II diabetes mellitus_Homo sapiens_hsa049300.36310251
158Oxytocin signaling pathway_Homo sapiens_hsa049210.35745694
159Circadian entrainment_Homo sapiens_hsa047130.34952171
160Metabolic pathways_Homo sapiens_hsa011000.33836952
161Caffeine metabolism_Homo sapiens_hsa002320.33770164
162Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31771774

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