PPM1AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial fragmentation involved in apoptotic process (GO:0043653)7.07593538
2C21-steroid hormone biosynthetic process (GO:0006700)5.81840650
3forebrain neuron differentiation (GO:0021879)5.08509785
4anterior/posterior axis specification, embryo (GO:0008595)4.79299739
5organ induction (GO:0001759)4.57831027
6nonmotile primary cilium assembly (GO:0035058)4.44939282
7regulation of development, heterochronic (GO:0040034)4.30979667
8mitochondrial fission (GO:0000266)4.26862104
9cell fate commitment involved in formation of primary germ layer (GO:0060795)4.13057920
10positive regulation of cardiac muscle cell proliferation (GO:0060045)4.04434456
11acrosome assembly (GO:0001675)4.01649525
12regulation of timing of cell differentiation (GO:0048505)3.73630798
13DNA double-strand break processing (GO:0000729)3.72877659
14positive regulation of cardiac muscle tissue growth (GO:0055023)3.71771409
15olfactory bulb development (GO:0021772)3.71100837
16mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.54430432
17regulation of sulfur metabolic process (GO:0042762)3.52587520
18regulation of sister chromatid cohesion (GO:0007063)3.47783320
19regulation of mesoderm development (GO:2000380)3.46120886
20branching involved in labyrinthine layer morphogenesis (GO:0060670)3.42240397
21mammary gland alveolus development (GO:0060749)3.40498792
22progesterone metabolic process (GO:0042448)3.37603882
23regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.35249224
24regulation of cardiac muscle cell proliferation (GO:0060043)3.21283818
25mammary gland epithelial cell differentiation (GO:0060644)3.19683681
26positive regulation of heart growth (GO:0060421)3.19312173
27embryonic foregut morphogenesis (GO:0048617)3.18367584
28positive regulation of cardiac muscle tissue development (GO:0055025)3.17066629
29regulation of coenzyme metabolic process (GO:0051196)3.15750684
30regulation of cofactor metabolic process (GO:0051193)3.15750684
31regulation of secondary heart field cardioblast proliferation (GO:0003266)3.12133265
32regulation of cardioblast proliferation (GO:0003264)3.12133265
33regulation of acyl-CoA biosynthetic process (GO:0050812)3.10900786
34axoneme assembly (GO:0035082)3.05616849
35positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98317927
36positive regulation of endothelial cell differentiation (GO:0045603)2.98082867
37pyrimidine nucleobase catabolic process (GO:0006208)2.97128747
38developmental induction (GO:0031128)2.96350958
39lymphangiogenesis (GO:0001946)2.95367652
40regulation of cilium movement (GO:0003352)2.94653869
41regulation of organ formation (GO:0003156)2.92371026
42cilium morphogenesis (GO:0060271)2.92299081
43regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.91877306
44sequestering of extracellular ligand from receptor (GO:0035581)2.90581045
45negative regulation of keratinocyte proliferation (GO:0010839)2.84188758
46anterior/posterior axis specification (GO:0009948)2.83998307
47embryonic heart tube development (GO:0035050)2.82682032
48response to lipoprotein particle (GO:0055094)2.82616910
49retinal ganglion cell axon guidance (GO:0031290)2.81120654
50cell-cell signaling involved in cell fate commitment (GO:0045168)2.80658671
51regulation of cardioblast differentiation (GO:0051890)2.80465405
52positive regulation of mitochondrial fission (GO:0090141)2.80082172
53chromatin remodeling at centromere (GO:0031055)2.78568440
54embryonic pattern specification (GO:0009880)2.77322491
55ventricular cardiac muscle cell development (GO:0055015)2.74393681
56lipopolysaccharide biosynthetic process (GO:0009103)2.70087396
57photoreceptor cell maintenance (GO:0045494)2.69640336
58CENP-A containing nucleosome assembly (GO:0034080)2.63208574
59lung-associated mesenchyme development (GO:0060484)2.61867516
60behavioral defense response (GO:0002209)2.58982890
61behavioral fear response (GO:0001662)2.58982890
62regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57109999
63mesenchymal-epithelial cell signaling (GO:0060638)2.56581528
64limb development (GO:0060173)2.51143625
65appendage development (GO:0048736)2.51143625
66negative regulation of chondrocyte differentiation (GO:0032331)2.49922361
67negative regulation of response to food (GO:0032096)2.49854032
68negative regulation of appetite (GO:0032099)2.49854032
69regulation of cardiac muscle tissue growth (GO:0055021)2.49760207
70organ formation (GO:0048645)2.48641978
71glial cell proliferation (GO:0014009)2.47365913
72bone trabecula formation (GO:0060346)2.44963522
73hyperosmotic salinity response (GO:0042538)2.43468315
74positive regulation of muscle organ development (GO:0048636)2.43053059
75positive regulation of striated muscle tissue development (GO:0045844)2.43053059
76midgut development (GO:0007494)2.41340168
77short-term memory (GO:0007614)2.41295545
78pyrimidine dimer repair (GO:0006290)2.40507813
79regulation of centriole replication (GO:0046599)2.38409387
80regulation of mRNA splicing, via spliceosome (GO:0048024)2.37937713
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.37479770
82regulation of tight junction assembly (GO:2000810)2.36056132
83regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.36055228
84sister chromatid segregation (GO:0000819)2.35366613
85positive regulation of muscle tissue development (GO:1901863)2.34385432
86chondrocyte proliferation (GO:0035988)2.33700520
87negative regulation of cell fate specification (GO:0009996)2.33173784
88mesenchymal cell proliferation (GO:0010463)2.31564211
89fatty acid elongation (GO:0030497)2.31479683
90nucleobase catabolic process (GO:0046113)2.30931921
91C21-steroid hormone metabolic process (GO:0008207)2.30396774
92histone H3-K9 demethylation (GO:0033169)2.29845795
93embryonic axis specification (GO:0000578)2.29430657
94cell wall macromolecule catabolic process (GO:0016998)2.29321109
95neural crest cell migration (GO:0001755)2.29130510
96layer formation in cerebral cortex (GO:0021819)2.29075518
97response to X-ray (GO:0010165)2.27701524
98negative regulation of activin receptor signaling pathway (GO:0032926)2.27163866
99UDP-N-acetylglucosamine metabolic process (GO:0006047)2.26868179
100DNA replication-dependent nucleosome assembly (GO:0006335)2.25966595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.62107273
2E2F7_22180533_ChIP-Seq_HELA_Human3.07035570
3IGF1R_20145208_ChIP-Seq_DFB_Human3.03865823
4GBX2_23144817_ChIP-Seq_PC3_Human2.93891649
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67145099
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61757985
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54603908
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30683022
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28645323
10FUS_26573619_Chip-Seq_HEK293_Human2.24248687
11ZNF274_21170338_ChIP-Seq_K562_Hela2.21540917
12P300_19829295_ChIP-Seq_ESCs_Human2.12359124
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10829889
14TAF15_26573619_Chip-Seq_HEK293_Human2.02771759
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01785245
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.95894442
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93990503
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93491140
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86371586
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85932667
21EWS_26573619_Chip-Seq_HEK293_Human1.78522739
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77297649
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76758408
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76505664
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71883013
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.69576875
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63101054
28IRF1_19129219_ChIP-ChIP_H3396_Human1.58226655
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55877134
30EZH2_22144423_ChIP-Seq_EOC_Human1.55095458
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52721369
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52010404
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50235463
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48732623
35TP53_18474530_ChIP-ChIP_U2OS_Human1.45741435
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43597754
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42745701
38SMAD4_21799915_ChIP-Seq_A2780_Human1.42114231
39VDR_22108803_ChIP-Seq_LS180_Human1.41527795
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41391275
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.41000129
42AR_25329375_ChIP-Seq_VCAP_Human1.40427322
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38834711
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37354852
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36904815
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.36336338
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36332749
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.34159145
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31837947
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31662255
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30830175
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.30668268
53TP53_16413492_ChIP-PET_HCT116_Human1.29413201
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.28490301
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27345583
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27328732
57STAT3_23295773_ChIP-Seq_U87_Human1.25967099
58CJUN_26792858_Chip-Seq_BT549_Human1.25353341
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24377443
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.22260637
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22035294
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21553327
63BRD4_25478319_ChIP-Seq_HGPS_Human1.21303129
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20418436
65ELK1_19687146_ChIP-ChIP_HELA_Human1.20009359
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19849620
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19725453
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18304588
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.17076669
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.16771641
71TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14468095
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14310467
73TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13481380
74SMAD4_21741376_ChIP-Seq_HESCs_Human1.13478160
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.13294980
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13027837
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12522463
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.10085128
79TCF4_23295773_ChIP-Seq_U87_Human1.09537472
80RNF2_27304074_Chip-Seq_NSC_Mouse1.08379024
81POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07346561
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06350774
83JUN_21703547_ChIP-Seq_K562_Human1.06230600
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06135216
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.05489014
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04893377
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04659311
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04653345
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04052914
90RUNX2_22187159_ChIP-Seq_PCA_Human1.03507343
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.03361111
92KDM2B_26808549_Chip-Seq_REH_Human1.02384649
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.02148779
94AR_21909140_ChIP-Seq_LNCAP_Human1.01590671
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01414911
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01414911
97SOX9_26525672_Chip-Seq_HEART_Mouse1.01216677
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00919810
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00356035
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99394338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.51078154
2MP0001984_abnormal_olfaction3.14484585
3MP0008004_abnormal_stomach_pH2.93404591
4MP0006072_abnormal_retinal_apoptosis2.66829693
5MP0010234_abnormal_vibrissa_follicle2.66155101
6MP0002736_abnormal_nociception_after2.63650046
7MP0005647_abnormal_sex_gland2.51765041
8MP0002653_abnormal_ependyma_morphology2.45362687
9MP0004272_abnormal_basement_membrane2.36545690
10MP0008789_abnormal_olfactory_epithelium2.24215892
11MP0003119_abnormal_digestive_system2.22785276
12MP0008438_abnormal_cutaneous_collagen2.20347071
13MP0005499_abnormal_olfactory_system2.17570898
14MP0005394_taste/olfaction_phenotype2.17570898
15MP0003890_abnormal_embryonic-extraembry2.12593658
16MP0004233_abnormal_muscle_weight2.10385838
17MP0008932_abnormal_embryonic_tissue1.90791300
18MP0009053_abnormal_anal_canal1.78771401
19MP0000537_abnormal_urethra_morphology1.75325507
20MP0010368_abnormal_lymphatic_system1.73026512
21MP0005253_abnormal_eye_physiology1.63138463
22MP0009384_cardiac_valve_regurgitation1.58422887
23MP0003937_abnormal_limbs/digits/tail_de1.55354812
24MP0010094_abnormal_chromosome_stability1.54801528
25MP0005248_abnormal_Harderian_gland1.49489286
26MP0005623_abnormal_meninges_morphology1.48143549
27MP0008058_abnormal_DNA_repair1.47284297
28MP0000569_abnormal_digit_pigmentation1.44974705
29MP0005670_abnormal_white_adipose1.44485414
30MP0003693_abnormal_embryo_hatching1.44311357
31MP0004133_heterotaxia1.43673140
32MP0000778_abnormal_nervous_system1.43439153
33MP0005503_abnormal_tendon_morphology1.43373933
34MP0000751_myopathy1.43076105
35MP0002282_abnormal_trachea_morphology1.38628213
36MP0001968_abnormal_touch/_nociception1.37810322
37MP0004215_abnormal_myocardial_fiber1.35006823
38MP0003880_abnormal_central_pattern1.31100288
39MP0001293_anophthalmia1.30808627
40MP0005187_abnormal_penis_morphology1.30789322
41MP0002751_abnormal_autonomic_nervous1.25918666
42MP0000013_abnormal_adipose_tissue1.25903236
43MP0003137_abnormal_impulse_conducting1.25148475
44MP0003221_abnormal_cardiomyocyte_apopto1.14780667
45MP0002697_abnormal_eye_size1.13307268
46MP0006292_abnormal_olfactory_placode1.13175692
47MP0005257_abnormal_intraocular_pressure1.12695316
48MP0002102_abnormal_ear_morphology1.12115838
49MP0001177_atelectasis1.11769653
50MP0000428_abnormal_craniofacial_morphol1.10662734
51MP0005391_vision/eye_phenotype1.06856216
52MP0005275_abnormal_skin_tensile1.04282291
53MP0003385_abnormal_body_wall1.03809010
54MP0000462_abnormal_digestive_system1.01630416
55MP0003786_premature_aging1.01078882
56MP0001881_abnormal_mammary_gland0.99499921
57MP0000647_abnormal_sebaceous_gland0.98229901
58MP0004147_increased_porphyrin_level0.97970778
59MP0006035_abnormal_mitochondrial_morpho0.97399753
60MP0002184_abnormal_innervation0.96475170
61MP0010030_abnormal_orbit_morphology0.95660715
62MP0002234_abnormal_pharynx_morphology0.93249339
63MP0001542_abnormal_bone_strength0.93110462
64MP0001958_emphysema0.90616907
65MP0002233_abnormal_nose_morphology0.90227559
66MP0000049_abnormal_middle_ear0.87677522
67MP0002160_abnormal_reproductive_system0.87668156
68MP0004197_abnormal_fetal_growth/weight/0.86438107
69MP0004859_abnormal_synaptic_plasticity0.86083240
70MP0010678_abnormal_skin_adnexa0.86064996
71MP0005330_cardiomyopathy0.85759481
72MP0009780_abnormal_chondrocyte_physiolo0.85329315
73MP0002734_abnormal_mechanical_nocicepti0.85158862
74MP0005645_abnormal_hypothalamus_physiol0.83914751
75MP0002972_abnormal_cardiac_muscle0.83137520
76MP0009703_decreased_birth_body0.82989202
77MP0003283_abnormal_digestive_organ0.80254264
78MP0003936_abnormal_reproductive_system0.79888869
79MP0001915_intracranial_hemorrhage0.79821175
80MP0003942_abnormal_urinary_system0.79531770
81MP0002111_abnormal_tail_morphology0.79469297
82MP0003567_abnormal_fetal_cardiomyocyte0.79051225
83MP0000631_abnormal_neuroendocrine_gland0.77433928
84MP0004085_abnormal_heartbeat0.76341228
85MP0001879_abnormal_lymphatic_vessel0.75843191
86MP0003861_abnormal_nervous_system0.75782718
87MP0005423_abnormal_somatic_nervous0.75670835
88MP0003755_abnormal_palate_morphology0.75626591
89MP0009697_abnormal_copulation0.75469436
90MP0009250_abnormal_appendicular_skeleto0.74832611
91MP0002092_abnormal_eye_morphology0.73833069
92MP0001286_abnormal_eye_development0.73654436
93MP0005620_abnormal_muscle_contractility0.73370089
94MP0003115_abnormal_respiratory_system0.72877174
95MP0002896_abnormal_bone_mineralization0.71253417
96MP0003279_aneurysm0.71088428
97MP0000427_abnormal_hair_cycle0.70914006
98MP0003329_amyloid_beta_deposits0.69350687
99MP0002735_abnormal_chemical_nociception0.69206512
100MP0001672_abnormal_embryogenesis/_devel0.68612141

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)5.73841634
2Congenital primary aphakia (HP:0007707)4.98307991
3Gait imbalance (HP:0002141)4.92055645
4Male infertility (HP:0003251)4.58730126
5Medial flaring of the eyebrow (HP:0010747)4.49333722
6Nephrogenic diabetes insipidus (HP:0009806)4.22262955
7Premature rupture of membranes (HP:0001788)3.59204301
8Shoulder girdle muscle weakness (HP:0003547)3.54840356
9Poor coordination (HP:0002370)3.53821278
10Vaginal atresia (HP:0000148)3.48806254
11Genital tract atresia (HP:0001827)3.48571728
12Abnormality of the musculature of the pelvis (HP:0001469)3.40442373
13Abnormality of the hip-girdle musculature (HP:0001445)3.40442373
14Decreased testicular size (HP:0008734)3.15426728
15Aplasia/Hypoplasia of the lens (HP:0008063)3.10709542
16Pelvic girdle muscle weakness (HP:0003749)3.06020257
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98258538
18Abnormality of alanine metabolism (HP:0010916)2.98258538
19Hyperalaninemia (HP:0003348)2.98258538
20Entropion (HP:0000621)2.85981440
21Fused cervical vertebrae (HP:0002949)2.85479687
22Inability to walk (HP:0002540)2.80487320
23Limb-girdle muscle atrophy (HP:0003797)2.76203295
24Aplasia/hypoplasia of the humerus (HP:0006507)2.67012792
25Abnormality of glycolysis (HP:0004366)2.62327981
26Broad foot (HP:0001769)2.61319120
27Reduced subcutaneous adipose tissue (HP:0003758)2.60468143
28Increased serum pyruvate (HP:0003542)2.60451337
29Carpal bone hypoplasia (HP:0001498)2.57387481
30Gonadotropin excess (HP:0000837)2.52535598
31Abnormal auditory evoked potentials (HP:0006958)2.43133683
32Short tibia (HP:0005736)2.39444884
33Abnormality of abdominal situs (HP:0011620)2.38723092
34Abdominal situs inversus (HP:0003363)2.38723092
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.38437249
36Dental crowding (HP:0000678)2.38203092
37Abnormality of the distal phalanges of the toes (HP:0010182)2.37378900
38Ankle contracture (HP:0006466)2.36296536
39Short 1st metacarpal (HP:0010034)2.34861788
40Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.34861788
41Spastic diplegia (HP:0001264)2.32878443
42Leiomyosarcoma (HP:0100243)2.15538750
43Uterine leiomyosarcoma (HP:0002891)2.15538750
44Abnormality of the parathyroid morphology (HP:0011766)2.15393808
45Anosmia (HP:0000458)2.11974768
46Limb-girdle muscle weakness (HP:0003325)2.11884147
47Astigmatism (HP:0000483)2.10866021
48Adrenal hypoplasia (HP:0000835)2.10346293
49Aplasia/Hypoplasia involving the musculature (HP:0001460)2.09872073
50Abnormality of dentin (HP:0010299)2.07474124
51Micropenis (HP:0000054)2.07105633
52Specific learning disability (HP:0001328)2.03503035
53Abnormality of the nasal septum (HP:0000419)2.02236232
54Increased variability in muscle fiber diameter (HP:0003557)2.02101504
55Abnormality of the shoulder girdle musculature (HP:0001435)2.01368916
56Short foot (HP:0001773)2.01333612
57Amyotrophic lateral sclerosis (HP:0007354)1.99184186
58Aplasia/hypoplasia of the uterus (HP:0008684)1.98694563
59Pancreatic cysts (HP:0001737)1.98597605
60Cortical dysplasia (HP:0002539)1.98153140
61Follicular hyperkeratosis (HP:0007502)1.97960625
62Ectopic kidney (HP:0000086)1.97102834
63Abnormality of the 1st metacarpal (HP:0010009)1.96203764
64Transitional cell carcinoma of the bladder (HP:0006740)1.95903385
65Male pseudohermaphroditism (HP:0000037)1.94757771
66Hypoplastic pelvis (HP:0008839)1.94513851
67Aplasia/Hypoplasia of the tongue (HP:0010295)1.94489245
68Pancreatic fibrosis (HP:0100732)1.93793928
69Left ventricular hypertrophy (HP:0001712)1.91704615
70Horseshoe kidney (HP:0000085)1.89612643
71Short nail (HP:0001799)1.89183011
72Termporal pattern (HP:0011008)1.84732333
73Insidious onset (HP:0003587)1.84732333
74Short humerus (HP:0005792)1.83550259
75Aganglionic megacolon (HP:0002251)1.82768358
76Bladder carcinoma (HP:0002862)1.82271153
77Bladder neoplasm (HP:0009725)1.82271153
78Abnormal biliary tract physiology (HP:0012439)1.80837438
79Bile duct proliferation (HP:0001408)1.80837438
80True hermaphroditism (HP:0010459)1.80604479
81Hypoplasia of the iris (HP:0007676)1.80440850
82Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79540216
83Postaxial hand polydactyly (HP:0001162)1.78786692
84Bifid tongue (HP:0010297)1.78230895
85Supernumerary spleens (HP:0009799)1.77340579
86Soft skin (HP:0000977)1.77047051
87Delayed gross motor development (HP:0002194)1.76263456
88Thyroid-stimulating hormone excess (HP:0002925)1.74843064
89Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72345665
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.71398892
91Preaxial hand polydactyly (HP:0001177)1.70685426
92Slender build (HP:0001533)1.69997916
93Small hand (HP:0200055)1.69470908
94Vitreoretinal degeneration (HP:0000655)1.68028752
95Meckel diverticulum (HP:0002245)1.66520841
96Intellectual disability, moderate (HP:0002342)1.66328649
97Abnormality of the calf musculature (HP:0001430)1.64376262
98Short clavicles (HP:0000894)1.60136737
99Fibular hypoplasia (HP:0003038)1.60047276
100Morphological abnormality of the middle ear (HP:0008609)1.59676697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB47.56885932
2SRPK16.62306944
3PDK24.01507081
4GRK73.92962614
5LATS12.69268593
6CSNK1A1L2.07224306
7CSNK1G32.02404731
8BCR1.92996126
9NEK91.90586446
10PLK21.85871766
11EIF2AK31.79536074
12TESK11.74180643
13CSNK1G11.66704147
14CSNK1G21.65835152
15TRIM281.64441797
16EIF2AK11.61237623
17TSSK61.60910828
18PAK41.56124491
19LIMK11.55251850
20PLK41.46159889
21RPS6KA41.35385444
22FER1.19509650
23CDC71.17075500
24NUAK11.09417405
25PAK61.05298604
26TESK21.04280934
27GRK10.97736182
28MOS0.95713034
29PAK30.94639811
30ERBB30.90802040
31CAMKK20.90771072
32CCNB10.90762219
33BRSK20.90228936
34EIF2AK20.90131059
35MYLK0.87753768
36BRD40.87660169
37WNK30.86129132
38BUB10.84365721
39ADRBK10.83729942
40PLK30.83564181
41BRSK10.83107932
42DDR20.82062481
43PBK0.80271331
44STK160.79792950
45TGFBR20.72826541
46TNIK0.72310931
47CDK60.72091804
48FGR0.70488049
49PLK10.70255690
50DYRK30.70034636
51MKNK10.65698670
52EPHA40.65597469
53EPHB10.62297847
54CAMK2B0.59957877
55GRK50.59424538
56EPHB20.59161823
57ROCK20.59142579
58TTK0.57024528
59NEK10.56461278
60CDK90.55978569
61MARK10.55171201
62DYRK20.52516184
63DAPK10.51310052
64ERBB20.51228252
65CDK190.49607866
66CAMK2A0.49550686
67DYRK1A0.48536476
68STK100.48125990
69CDK120.45319477
70CDK140.44363272
71CASK0.44111719
72FRK0.44086055
73CDK180.43864324
74STK38L0.43519296
75AURKA0.43161095
76PINK10.41745168
77PKN10.41578618
78STK30.40416735
79LATS20.39728895
80WEE10.39635943
81CDK150.39026376
82PRKCE0.37879770
83CDK11A0.36471923
84PTK2B0.35947479
85AKT20.35574112
86PRKCG0.34158539
87GSK3A0.33509449
88CSNK1D0.32519304
89MAP4K20.31908177
90AURKB0.31286991
91PTK60.31026134
92CSNK1A10.30040303
93CAMK2G0.29127170
94PDGFRA0.27903411
95CDK50.26740756
96CHEK10.25402595
97CDK30.24097172
98MAP3K120.22584514
99CHEK20.22099067
100VRK20.21350046

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.83336848
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64761934
3Homologous recombination_Homo sapiens_hsa034402.40957966
4Fanconi anemia pathway_Homo sapiens_hsa034602.27760950
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27062887
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.21701070
7Basal cell carcinoma_Homo sapiens_hsa052172.05531071
8Nicotine addiction_Homo sapiens_hsa050332.05490284
9Pyruvate metabolism_Homo sapiens_hsa006202.02192169
10DNA replication_Homo sapiens_hsa030301.99552680
11Fatty acid biosynthesis_Homo sapiens_hsa000611.69969671
12Hedgehog signaling pathway_Homo sapiens_hsa043401.64991637
13Vitamin B6 metabolism_Homo sapiens_hsa007501.60828144
14Fatty acid metabolism_Homo sapiens_hsa012121.60674381
15Non-homologous end-joining_Homo sapiens_hsa034501.58500026
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58143403
17Hippo signaling pathway_Homo sapiens_hsa043901.57465774
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56254996
19Propanoate metabolism_Homo sapiens_hsa006401.53873332
20ECM-receptor interaction_Homo sapiens_hsa045121.52654019
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52272865
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50822394
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49606659
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47082364
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42033945
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41359073
27Fatty acid elongation_Homo sapiens_hsa000621.40937551
28Steroid biosynthesis_Homo sapiens_hsa001001.40527209
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35343377
30Nucleotide excision repair_Homo sapiens_hsa034201.31617372
31Linoleic acid metabolism_Homo sapiens_hsa005911.30821141
32Adherens junction_Homo sapiens_hsa045201.28472533
33Spliceosome_Homo sapiens_hsa030401.14957566
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.06436345
35Fatty acid degradation_Homo sapiens_hsa000711.06365684
36Ovarian steroidogenesis_Homo sapiens_hsa049131.06163834
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05927843
38Tight junction_Homo sapiens_hsa045301.05372367
39Fat digestion and absorption_Homo sapiens_hsa049751.00903307
40Lysine degradation_Homo sapiens_hsa003100.99483057
41Oocyte meiosis_Homo sapiens_hsa041140.99466001
42Wnt signaling pathway_Homo sapiens_hsa043100.97601550
43Pyrimidine metabolism_Homo sapiens_hsa002400.97520658
44Cell cycle_Homo sapiens_hsa041100.97030096
45Phototransduction_Homo sapiens_hsa047440.95704012
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95564362
47GABAergic synapse_Homo sapiens_hsa047270.95289424
48RNA polymerase_Homo sapiens_hsa030200.95251965
49Olfactory transduction_Homo sapiens_hsa047400.94113071
50Glutamatergic synapse_Homo sapiens_hsa047240.89188184
51Basal transcription factors_Homo sapiens_hsa030220.88855432
52N-Glycan biosynthesis_Homo sapiens_hsa005100.86202196
53mRNA surveillance pathway_Homo sapiens_hsa030150.86141678
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86002498
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85510286
56Proteoglycans in cancer_Homo sapiens_hsa052050.83996882
57TGF-beta signaling pathway_Homo sapiens_hsa043500.83086847
58Melanogenesis_Homo sapiens_hsa049160.77972717
59Focal adhesion_Homo sapiens_hsa045100.77086363
60Proteasome_Homo sapiens_hsa030500.76105413
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.75696020
62Melanoma_Homo sapiens_hsa052180.73760858
63Carbon metabolism_Homo sapiens_hsa012000.72805784
64Axon guidance_Homo sapiens_hsa043600.71069706
65RNA transport_Homo sapiens_hsa030130.70584325
66Ether lipid metabolism_Homo sapiens_hsa005650.70277626
67Base excision repair_Homo sapiens_hsa034100.69265290
68Glutathione metabolism_Homo sapiens_hsa004800.68957249
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68721479
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67860535
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65379991
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63395039
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61853114
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61660378
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61634421
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60823095
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59080730
78RNA degradation_Homo sapiens_hsa030180.58660323
79Biosynthesis of amino acids_Homo sapiens_hsa012300.58350754
80Colorectal cancer_Homo sapiens_hsa052100.58227824
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55850130
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53379561
83Gastric acid secretion_Homo sapiens_hsa049710.53351787
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53208565
85Alcoholism_Homo sapiens_hsa050340.52536222
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52127401
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52041897
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52003567
89Dilated cardiomyopathy_Homo sapiens_hsa054140.50765435
90Taste transduction_Homo sapiens_hsa047420.50217017
91Thyroid cancer_Homo sapiens_hsa052160.49964407
92Sulfur metabolism_Homo sapiens_hsa009200.49938648
93beta-Alanine metabolism_Homo sapiens_hsa004100.49416891
94Calcium signaling pathway_Homo sapiens_hsa040200.48613402
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.48170958
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47752829
97Gap junction_Homo sapiens_hsa045400.47350617
98Prolactin signaling pathway_Homo sapiens_hsa049170.46896274
99Circadian entrainment_Homo sapiens_hsa047130.43538950
100Morphine addiction_Homo sapiens_hsa050320.42583710

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