PPM1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)8.33753161
2sperm motility (GO:0030317)8.02027899
3multicellular organism reproduction (GO:0032504)7.99382175
4acrosome assembly (GO:0001675)7.90935624
5cilium or flagellum-dependent cell motility (GO:0001539)7.84174433
6plasma membrane fusion (GO:0045026)7.78026385
7cell-cell recognition (GO:0009988)7.47177243
8binding of sperm to zona pellucida (GO:0007339)7.44570645
9motile cilium assembly (GO:0044458)7.08167312
10reproduction (GO:0000003)6.74339985
11axonemal dynein complex assembly (GO:0070286)6.66706217
12piRNA metabolic process (GO:0034587)6.64001387
13acrosome reaction (GO:0007340)6.46074359
14spermatid development (GO:0007286)6.37622472
15epithelial cilium movement (GO:0003351)6.21131671
16male meiosis (GO:0007140)5.86338043
17synaptonemal complex assembly (GO:0007130)5.53901558
18protein K11-linked deubiquitination (GO:0035871)5.51372739
19synaptonemal complex organization (GO:0070193)5.45878770
20microtubule depolymerization (GO:0007019)5.29179693
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.20548009
22regulation of cilium movement (GO:0003352)5.12591088
23single fertilization (GO:0007338)5.03836427
24cilium movement (GO:0003341)4.91976162
25nuclear pore complex assembly (GO:0051292)4.90971040
26regulation of establishment of cell polarity (GO:2000114)4.75325346
27regulation of centrosome duplication (GO:0010824)4.64860005
28mitotic sister chromatid cohesion (GO:0007064)4.43010202
29DNA methylation involved in gamete generation (GO:0043046)4.41808146
30hepatocyte apoptotic process (GO:0097284)4.37722940
31spermatogenesis (GO:0007283)4.36540103
32fertilization (GO:0009566)4.36292791
33male gamete generation (GO:0048232)4.35589341
34nuclear pore organization (GO:0006999)4.31807467
35regulation of establishment or maintenance of cell polarity (GO:0032878)4.29421787
36negative regulation of inclusion body assembly (GO:0090084)4.29046587
37chromosome condensation (GO:0030261)4.22032799
38meiotic nuclear division (GO:0007126)4.12359610
39sperm capacitation (GO:0048240)4.06017558
40gamete generation (GO:0007276)4.03080522
41DNA packaging (GO:0006323)4.02528003
42gene silencing by RNA (GO:0031047)4.00935975
43chromosome organization involved in meiosis (GO:0070192)4.00222343
44germ cell development (GO:0007281)3.92882036
45regulation of cell proliferation involved in kidney development (GO:1901722)3.89615651
46protein localization to chromosome, centromeric region (GO:0071459)3.88279031
47cellular process involved in reproduction in multicellular organism (GO:0022412)3.86755308
48intestinal epithelial cell development (GO:0060576)3.83797640
49monoubiquitinated protein deubiquitination (GO:0035520)3.66165833
50pore complex assembly (GO:0046931)3.64204785
51male meiosis I (GO:0007141)3.62863988
52regulation of centriole replication (GO:0046599)3.60004822
53DNA replication-dependent nucleosome assembly (GO:0006335)3.59184787
54DNA replication-dependent nucleosome organization (GO:0034723)3.59184787
55ventricular system development (GO:0021591)3.53300184
56regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.53213490
57striated muscle atrophy (GO:0014891)3.51279122
58vagina development (GO:0060068)3.49592489
59positive regulation of keratinocyte differentiation (GO:0045618)3.46206004
60spermatid nucleus differentiation (GO:0007289)3.46051250
61regulation of inclusion body assembly (GO:0090083)3.45550826
62meiotic cell cycle (GO:0051321)3.41647795
63gene silencing (GO:0016458)3.39862880
64cell recognition (GO:0008037)3.33221851
65pyrimidine dimer repair (GO:0006290)3.32575883
66regulation of histone H3-K9 methylation (GO:0051570)3.31006852
67protein K48-linked deubiquitination (GO:0071108)3.29088421
68embryonic camera-type eye morphogenesis (GO:0048596)3.28833937
69negative regulation of organelle assembly (GO:1902116)3.26697564
70meiosis I (GO:0007127)3.22724617
71ear development (GO:0043583)3.22595150
72chaperone-mediated protein complex assembly (GO:0051131)3.22311207
73seminiferous tubule development (GO:0072520)3.20299591
74microtubule severing (GO:0051013)3.19610511
75nucleus organization (GO:0006997)3.16026037
76multicellular organismal reproductive process (GO:0048609)3.14466730
77female genitalia development (GO:0030540)3.12646410
78epithelial cell maturation (GO:0002070)3.11274431
79sister chromatid cohesion (GO:0007062)3.10470404
80muscle atrophy (GO:0014889)3.10278205
81histone exchange (GO:0043486)3.09799039
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09631482
83cardiac right ventricle morphogenesis (GO:0003215)3.07627284
84regulation of spindle checkpoint (GO:0090231)3.06117146
85organic cation transport (GO:0015695)3.05822444
86protein-DNA complex disassembly (GO:0032986)3.03203460
87nucleosome disassembly (GO:0006337)3.03203460
88mitotic sister chromatid segregation (GO:0000070)3.02760953
89translesion synthesis (GO:0019985)3.01185667
90mitotic nuclear envelope disassembly (GO:0007077)3.00530988
91TOR signaling (GO:0031929)2.98715807
92meiotic cell cycle process (GO:1903046)2.97986308
93sister chromatid segregation (GO:0000819)2.97325901
94spliceosomal tri-snRNP complex assembly (GO:0000244)2.96398933
95skeletal muscle adaptation (GO:0043501)2.94052387
96DNA double-strand break processing (GO:0000729)2.92213633
97genitalia morphogenesis (GO:0035112)2.91187040
98regulation of RNA export from nucleus (GO:0046831)2.91017796
99protein K6-linked ubiquitination (GO:0085020)2.90757704
100positive regulation of mitotic sister chromatid separation (GO:1901970)2.90188659
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90188659
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90188659
103heterochromatin organization (GO:0070828)2.89717782
104membrane disassembly (GO:0030397)2.88958838
105nuclear envelope disassembly (GO:0051081)2.88958838
106chromatin silencing (GO:0006342)2.88337086
107centriole assembly (GO:0098534)2.87671864
108chromatin assembly (GO:0031497)2.84489127
109regulation of microtubule-based movement (GO:0060632)2.83216404
110positive regulation of translational initiation (GO:0045948)2.83097536
111pre-miRNA processing (GO:0031054)2.82560322
112mitotic chromosome condensation (GO:0007076)2.82161153
113regulation of hippo signaling (GO:0035330)2.81895457
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.81551014
115regulation of translation, ncRNA-mediated (GO:0045974)2.81551014
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81551014
117viral mRNA export from host cell nucleus (GO:0046784)2.81147855
118centriole replication (GO:0007099)2.80660253
119sympathetic nervous system development (GO:0048485)2.78764732
120replication fork processing (GO:0031297)2.77815171
121prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.77193740
122regulation of chromosome segregation (GO:0051983)2.76911245
123neural tube formation (GO:0001841)2.75623997
124glycerol ether metabolic process (GO:0006662)2.75592355
125regulation of DNA endoreduplication (GO:0032875)2.75014643
126regulation of centrosome cycle (GO:0046605)2.71269248
127response to UV-C (GO:0010225)2.71229724
128regulation of response to osmotic stress (GO:0047484)2.70091880
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69689159
130single strand break repair (GO:0000012)2.69530740
131negative regulation of gene expression, epigenetic (GO:0045814)2.68269491
132uterus development (GO:0060065)2.68249032
133protein localization to kinetochore (GO:0034501)2.68166734
134postreplication repair (GO:0006301)2.67953356
135DNA conformation change (GO:0071103)2.65180642
136multicellular organismal development (GO:0007275)2.65140651
137DNA topological change (GO:0006265)2.62874275
138regulation of chromatin binding (GO:0035561)2.61843418
139post-embryonic morphogenesis (GO:0009886)2.58804791
140protein sumoylation (GO:0016925)2.58431305
141DNA replication checkpoint (GO:0000076)2.57889591
142recombinational repair (GO:0000725)2.56765605
143double-strand break repair via homologous recombination (GO:0000724)2.56055532
144DNA-dependent DNA replication (GO:0006261)2.55505176
145mesonephros development (GO:0001823)2.52647867
146embryonic eye morphogenesis (GO:0048048)2.49542743
147histone H3-K9 methylation (GO:0051567)2.48388007
148nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.47430437
149DNA strand elongation (GO:0022616)2.47223785
150DNA integration (GO:0015074)2.46867378
151inner cell mass cell proliferation (GO:0001833)2.46324132
152peptidyl-lysine trimethylation (GO:0018023)2.46275075
153protein K63-linked deubiquitination (GO:0070536)2.46029390
154attachment of spindle microtubules to kinetochore (GO:0008608)2.45894713
155ER overload response (GO:0006983)2.44940643
156* peptidyl-threonine dephosphorylation (GO:0035970)2.43118046
157regulation of histone H3-K4 methylation (GO:0051569)2.42821493
158negative regulation of Ras GTPase activity (GO:0034261)2.40452057
159cell differentiation involved in embryonic placenta development (GO:0060706)2.38824897
160response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.38382495
161norepinephrine metabolic process (GO:0042415)2.37313151
162DNA geometric change (GO:0032392)2.35884958
163regulation of sister chromatid cohesion (GO:0007063)2.34937394
164nodal signaling pathway (GO:0038092)2.34655500
165embryonic epithelial tube formation (GO:0001838)2.33927048
166positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.33519805
167positive regulation of cell cycle G2/M phase transition (GO:1902751)2.33519805
168positive regulation of epidermal cell differentiation (GO:0045606)2.33080070
169DNA unwinding involved in DNA replication (GO:0006268)2.33038280
170regulation of histone H3-K27 methylation (GO:0061085)2.32721887
171histone H2A monoubiquitination (GO:0035518)2.31873759
172histone H3-K4 trimethylation (GO:0080182)2.31783699
173DNA replication initiation (GO:0006270)2.31612253
174negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31496716
175negative regulation of mRNA processing (GO:0050686)2.31018880
176regulation of helicase activity (GO:0051095)2.29357366
177cell wall macromolecule metabolic process (GO:0044036)10.5456037
178cell wall macromolecule catabolic process (GO:0016998)10.5456037
179fusion of sperm to egg plasma membrane (GO:0007342)10.4207921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.62810572
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.15983376
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.65620798
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.64390412
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.25116244
6ER_23166858_ChIP-Seq_MCF-7_Human3.17599746
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15551753
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07782771
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.90414570
10* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.77308769
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76100612
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62135851
13EWS_26573619_Chip-Seq_HEK293_Human2.45443487
14SCL_19346495_ChIP-Seq_HPC-7_Human2.18432648
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.11303528
16AHR_22903824_ChIP-Seq_MCF-7_Human2.04354750
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00456707
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0117644
19MYC_22102868_ChIP-Seq_BL_Human1.97070903
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95417645
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86270882
22FOXM1_26456572_ChIP-Seq_MCF-7_Human1.77370234
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76231237
24IRF1_19129219_ChIP-ChIP_H3396_Human1.71497999
25FUS_26573619_Chip-Seq_HEK293_Human1.65554143
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62516155
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.62457811
28* DCP1A_22483619_ChIP-Seq_HELA_Human1.62389940
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62297658
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.62286923
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.62057057
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.61794163
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61263642
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60969704
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60447369
36TCF7_22412390_ChIP-Seq_EML_Mouse1.60299664
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.58546069
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57896731
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.57294967
40AR_21909140_ChIP-Seq_LNCAP_Human1.55959012
41* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53585510
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53534952
43TAF15_26573619_Chip-Seq_HEK293_Human1.51746065
44ELK1_19687146_ChIP-ChIP_HELA_Human1.51052085
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50679968
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.49047133
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48367660
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46815377
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.45251826
50IGF1R_20145208_ChIP-Seq_DFB_Human1.44141435
51FOXP3_21729870_ChIP-Seq_TREG_Human1.44094709
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40120010
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.38593891
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32341272
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29817753
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28861994
57* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28796042
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.28745364
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28583842
60* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27663000
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26394554
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25842331
63* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25546077
64GBX2_23144817_ChIP-Seq_PC3_Human1.25315582
65TP53_22573176_ChIP-Seq_HFKS_Human1.25272157
66GATA3_24758297_ChIP-Seq_MCF-7_Human1.23687929
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23234559
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21827322
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21827322
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21827322
71* GABP_19822575_ChIP-Seq_HepG2_Human1.18716873
72MYB_26560356_Chip-Seq_TH2_Human1.18328042
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17538136
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16780985
75MYC_18940864_ChIP-ChIP_HL60_Human1.15315453
76* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14983996
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14797357
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13658889
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12729934
80* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12218754
81XRN2_22483619_ChIP-Seq_HELA_Human1.10623812
82* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10422150
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10148002
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09806926
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.09244665
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09139095
87ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08811967
88TP53_16413492_ChIP-PET_HCT116_Human1.08731697
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.08682819
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07623579
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07599030
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07250078
93VDR_22108803_ChIP-Seq_LS180_Human1.07119387
94* MYB_26560356_Chip-Seq_TH1_Human1.06434273
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06187828
96ZNF274_21170338_ChIP-Seq_K562_Hela1.06130495
97VDR_21846776_ChIP-Seq_THP-1_Human1.04910378
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03125031
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02267899
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.01961485
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01256471
102UTX_26944678_Chip-Seq_JUKART_Human1.01213569
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00156191
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99787367
105GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.99771880
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98989583
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98959217
108GATA3_21867929_ChIP-Seq_CD8_Mouse0.98183719
109FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97866830
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97573774
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97424490
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.96887086
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96624256
114HOXB7_26014856_ChIP-Seq_BT474_Human0.95495287
115ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93284789
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.93207423
117SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92986406
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92971120
119P300_19829295_ChIP-Seq_ESCs_Human0.92315112
120SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91412512
121RUNX1_22412390_ChIP-Seq_EML_Mouse0.91410078
122SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91099427
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90828482
124FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89986480
125* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89679581
126KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89156071
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88680382
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.88163212
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87437136
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86408590
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85784563
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.85697615
133HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85441308
134SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84426230
135MAF_26560356_Chip-Seq_TH1_Human0.84073203
136* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83814126
137TFEB_21752829_ChIP-Seq_HELA_Human0.83811693
138* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83770703
139* NCOR1_26117541_ChIP-Seq_K562_Human0.83251466
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83156936
141KDM2B_26808549_Chip-Seq_DND41_Human0.82394537
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.82187811
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82042406
144RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81599393
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81591126
146P53_21459846_ChIP-Seq_SAOS-2_Human0.81562471
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81052494
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80520948
149KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79953030
150VDR_23849224_ChIP-Seq_CD4+_Human0.79415801
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79020571
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78776616
153TTF2_22483619_ChIP-Seq_HELA_Human0.78099836
154ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77806917
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77794796
156ELF5_23300383_ChIP-Seq_T47D_Human0.77783939
157* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.77732227
158CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76684241
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76342168
160KDM5A_27292631_Chip-Seq_BREAST_Human0.75941312
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.74720859
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.74208403
163* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74206659
164STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.73867058
165* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.72900060
166NOTCH1_21737748_ChIP-Seq_TLL_Human0.72403450
167PHF8_20622854_ChIP-Seq_HELA_Human0.71851320
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70263258
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69271321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.23422093
2MP0008877_abnormal_DNA_methylation5.00597034
3* MP0001929_abnormal_gametogenesis4.03611988
4* MP0003698_abnormal_male_reproductive4.00228911
5MP0010094_abnormal_chromosome_stability3.17605054
6MP0002653_abnormal_ependyma_morphology3.07758620
7MP0008057_abnormal_DNA_replication2.87836666
8MP0003111_abnormal_nucleus_morphology2.82047304
9* MP0002210_abnormal_sex_determination2.81632468
10MP0000427_abnormal_hair_cycle2.47938056
11* MP0001145_abnormal_male_reproductive2.46011885
12MP0003077_abnormal_cell_cycle2.41403736
13MP0000383_abnormal_hair_follicle2.32369545
14* MP0002161_abnormal_fertility/fecundity2.32193960
15MP0008058_abnormal_DNA_repair2.27903700
16MP0002751_abnormal_autonomic_nervous2.19170962
17* MP0000653_abnormal_sex_gland2.13578764
18MP0003693_abnormal_embryo_hatching2.11109853
19MP0004957_abnormal_blastocyst_morpholog2.08270363
20MP0008007_abnormal_cellular_replicative2.01393633
21MP0000569_abnormal_digit_pigmentation1.99670984
22MP0005367_renal/urinary_system_phenotyp1.96887017
23MP0000516_abnormal_urinary_system1.96887017
24MP0006292_abnormal_olfactory_placode1.92255952
25MP0010678_abnormal_skin_adnexa1.85478128
26MP0002098_abnormal_vibrissa_morphology1.84785716
27MP0004233_abnormal_muscle_weight1.77534123
28MP0001919_abnormal_reproductive_system1.75742629
29MP0004808_abnormal_hematopoietic_stem1.75128183
30MP0010307_abnormal_tumor_latency1.70508953
31MP0005397_hematopoietic_system_phenotyp1.69787017
32MP0001545_abnormal_hematopoietic_system1.69787017
33MP0001730_embryonic_growth_arrest1.66097474
34MP0010352_gastrointestinal_tract_polyps1.66077340
35MP0009278_abnormal_bone_marrow1.60681091
36MP0004381_abnormal_hair_follicle1.49270762
37MP0005076_abnormal_cell_differentiation1.49106374
38MP0005646_abnormal_pituitary_gland1.46713245
39MP0005623_abnormal_meninges_morphology1.45329678
40MP0003880_abnormal_central_pattern1.36095049
41MP0001286_abnormal_eye_development1.35478415
42MP0005075_abnormal_melanosome_morpholog1.34268646
43MP0001697_abnormal_embryo_size1.34148595
44MP0002084_abnormal_developmental_patter1.32531732
45MP0003937_abnormal_limbs/digits/tail_de1.30925513
46MP0005248_abnormal_Harderian_gland1.26900367
47MP0000350_abnormal_cell_proliferation1.26052388
48MP0003936_abnormal_reproductive_system1.25726291
49MP0001672_abnormal_embryogenesis/_devel1.24407778
50MP0005380_embryogenesis_phenotype1.24407778
51MP0003890_abnormal_embryonic-extraembry1.21954185
52MP0003942_abnormal_urinary_system1.20946512
53MP0004197_abnormal_fetal_growth/weight/1.20846904
54MP0003283_abnormal_digestive_organ1.18242746
55MP0002009_preneoplasia1.17116721
56MP0003984_embryonic_growth_retardation1.16804943
57MP0002282_abnormal_trachea_morphology1.16745354
58MP0002088_abnormal_embryonic_growth/wei1.13127236
59MP0000647_abnormal_sebaceous_gland1.12685454
60MP0000313_abnormal_cell_death1.11238373
61MP0002086_abnormal_extraembryonic_tissu1.10596352
62MP0000490_abnormal_crypts_of1.10221400
63MP0005423_abnormal_somatic_nervous1.10179855
64* MP0002080_prenatal_lethality1.10115987
65MP0002085_abnormal_embryonic_tissue1.09624016
66MP0003763_abnormal_thymus_physiology1.09081084
67MP0000627_abnormal_mammary_gland1.08649265
68MP0002234_abnormal_pharynx_morphology1.08593322
69MP0003221_abnormal_cardiomyocyte_apopto1.07014492
70MP0000538_abnormal_urinary_bladder1.06784858
71MP0000470_abnormal_stomach_morphology1.05149905
72* MP0002398_abnormal_bone_marrow1.03910693
73MP0001529_abnormal_vocalization1.02636394
74MP0008995_early_reproductive_senescence1.02574216
75MP0009703_decreased_birth_body1.02515357
76MP0002160_abnormal_reproductive_system1.00853087
77MP0006072_abnormal_retinal_apoptosis1.00463338
78MP0003786_premature_aging1.00252518
79* MP0000703_abnormal_thymus_morphology1.00018285
80MP0000462_abnormal_digestive_system0.99141427
81MP0001293_anophthalmia0.97469038
82MP0003123_paternal_imprinting0.96278290
83MP0009780_abnormal_chondrocyte_physiolo0.96051643
84MP0005499_abnormal_olfactory_system0.95603356
85MP0005394_taste/olfaction_phenotype0.95603356
86MP0000631_abnormal_neuroendocrine_gland0.94168358
87MP0002184_abnormal_innervation0.93771819
88MP0003115_abnormal_respiratory_system0.93309754
89MP0002697_abnormal_eye_size0.92987427
90MP0002736_abnormal_nociception_after0.92903677
91* MP0002019_abnormal_tumor_incidence0.92572122
92MP0009333_abnormal_splenocyte_physiolog0.92557019
93MP0002111_abnormal_tail_morphology0.92386175
94MP0003183_abnormal_peptide_metabolism0.92376284
95MP0002396_abnormal_hematopoietic_system0.92156106
96MP0003121_genomic_imprinting0.90255104
97MP0008932_abnormal_embryonic_tissue0.89561996
98MP0008789_abnormal_olfactory_epithelium0.89048996
99MP0002233_abnormal_nose_morphology0.87813893
100MP0000015_abnormal_ear_pigmentation0.87137499
101MP0001727_abnormal_embryo_implantation0.86629204
102MP0000685_abnormal_immune_system0.86032319
103MP0006054_spinal_hemorrhage0.84697802
104MP0001340_abnormal_eyelid_morphology0.84440264
105MP0005501_abnormal_skin_physiology0.83821833
106MP0000537_abnormal_urethra_morphology0.82692819
107MP0000534_abnormal_ureter_morphology0.82637589
108MP0000465_gastrointestinal_hemorrhage0.82033676
109MP0003941_abnormal_skin_development0.81981090
110MP0003718_maternal_effect0.81713769
111MP0009053_abnormal_anal_canal0.81500497
112MP0002928_abnormal_bile_duct0.80329188
113MP0002796_impaired_skin_barrier0.79824272
114* MP0002722_abnormal_immune_system0.79371225
115MP0003787_abnormal_imprinting0.77220052
116MP0002405_respiratory_system_inflammati0.76899611
117* MP0000689_abnormal_spleen_morphology0.76544474
118MP0003705_abnormal_hypodermis_morpholog0.72938328
119MP0003943_abnormal_hepatobiliary_system0.72407691
120MP0005253_abnormal_eye_physiology0.70326731
121MP0003567_abnormal_fetal_cardiomyocyte0.70095225
122* MP0002429_abnormal_blood_cell0.69860507
123MP0003699_abnormal_female_reproductive0.69389699
124MP0005551_abnormal_eye_electrophysiolog0.67910258
125MP0000733_abnormal_muscle_development0.66201986
126MP0005389_reproductive_system_phenotype0.65174081
127MP0005391_vision/eye_phenotype0.64900130
128MP0001119_abnormal_female_reproductive0.64702002
129MP0002166_altered_tumor_susceptibility0.64364597
130MP0003646_muscle_fatigue0.63322389
131* MP0000716_abnormal_immune_system0.63033397
132MP0003119_abnormal_digestive_system0.61812731
133MP0008961_abnormal_basal_metabolism0.61200210
134MP0002925_abnormal_cardiovascular_devel0.60558371
135MP0003861_abnormal_nervous_system0.58624480
136MP0001915_intracranial_hemorrhage0.58363113
137MP0004264_abnormal_extraembryonic_tissu0.56623142
138MP0003656_abnormal_erythrocyte_physiolo0.55269817
139MP0000358_abnormal_cell_content/0.54401407
140MP0000432_abnormal_head_morphology0.53769685
141MP0002092_abnormal_eye_morphology0.53382567
142MP0001800_abnormal_humoral_immune0.52345063
143MP0001784_abnormal_fluid_regulation0.52306679
144MP0005187_abnormal_penis_morphology0.51713934
145MP0010030_abnormal_orbit_morphology0.51462776
146MP0004133_heterotaxia0.50470602
147MP0002102_abnormal_ear_morphology0.50243144
148MP0003935_abnormal_craniofacial_develop0.49013758
149MP0001849_ear_inflammation0.48321410
150MP0008770_decreased_survivor_rate0.47215053

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.82533847
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.37391111
3Absent/shortened dynein arms (HP:0200106)9.37391111
4Abnormal respiratory epithelium morphology (HP:0012253)6.55401442
5Abnormal respiratory motile cilium morphology (HP:0005938)6.55401442
6Abnormal respiratory motile cilium physiology (HP:0012261)6.38593203
7Rhinitis (HP:0012384)5.87167909
8Nasal polyposis (HP:0100582)5.69808546
9Chronic bronchitis (HP:0004469)5.51537357
10Chromosomal breakage induced by crosslinking agents (HP:0003221)5.34101334
11Abnormality of the nasal mucosa (HP:0000433)4.80596434
12Abnormal ciliary motility (HP:0012262)4.79345499
13Infertility (HP:0000789)4.61163762
14Chromsome breakage (HP:0040012)4.60684294
15Bronchitis (HP:0012387)4.06884371
16Septate vagina (HP:0001153)3.96509778
17Bronchiectasis (HP:0002110)3.80293199
18Asymmetry of the thorax (HP:0001555)3.78006827
19Meckel diverticulum (HP:0002245)3.45747422
20J-shaped sella turcica (HP:0002680)3.45388846
21Concave nail (HP:0001598)3.40998885
22Microglossia (HP:0000171)3.39709632
23Abnormality of the ileum (HP:0001549)3.32965513
24Recurrent sinusitis (HP:0011108)3.26353397
25Male infertility (HP:0003251)3.15019086
26Recurrent otitis media (HP:0000403)3.14417246
27Cutaneous melanoma (HP:0012056)3.12277272
28Recurrent bronchitis (HP:0002837)3.10449047
29Abnormal spermatogenesis (HP:0008669)3.01575207
30Abnormality of the preputium (HP:0100587)3.01234959
31Nephronophthisis (HP:0000090)2.99184822
32Thyroid carcinoma (HP:0002890)2.89735664
33Neoplasm of the adrenal cortex (HP:0100641)2.85682981
34Progressive inability to walk (HP:0002505)2.70152832
35Heterotopia (HP:0002282)2.65185096
36Poikiloderma (HP:0001029)2.63875581
37Abnormality of the carotid arteries (HP:0005344)2.59463638
38Molar tooth sign on MRI (HP:0002419)2.58829387
39Abnormality of midbrain morphology (HP:0002418)2.58829387
40Absent radius (HP:0003974)2.57776745
41* Breast carcinoma (HP:0003002)2.57510625
42Embryonal renal neoplasm (HP:0011794)2.54663126
43Short thumb (HP:0009778)2.53605898
44Impulsivity (HP:0100710)2.50042871
45Aplasia involving forearm bones (HP:0009822)2.48613085
46Absent forearm bone (HP:0003953)2.48613085
47Hyperventilation (HP:0002883)2.46802664
48Patellar aplasia (HP:0006443)2.46262526
49Triphalangeal thumb (HP:0001199)2.43196462
50Curly hair (HP:0002212)2.42015225
51Midline defect of the nose (HP:0004122)2.42014972
52Micronodular cirrhosis (HP:0001413)2.38795675
53Supernumerary spleens (HP:0009799)2.38294649
54Bicornuate uterus (HP:0000813)2.34666058
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.32997406
56Pancreatic cysts (HP:0001737)2.32637325
57Carpal bone hypoplasia (HP:0001498)2.30897079
58Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.30620915
59Aplasia/Hypoplasia of the patella (HP:0006498)2.27139211
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25736386
61Clubbing of toes (HP:0100760)2.23909748
62Abnormality of the sella turcica (HP:0002679)2.21241792
63Arteriovenous malformation (HP:0100026)2.21070406
64Hypopigmentation of the fundus (HP:0007894)2.15036155
65Abnormality of the renal medulla (HP:0100957)2.10273076
66Abnormality of DNA repair (HP:0003254)2.08319037
67Azoospermia (HP:0000027)2.07757037
68Hypoplasia of the capital femoral epiphysis (HP:0003090)2.07048219
69Chronic hepatic failure (HP:0100626)2.05616166
70Astigmatism (HP:0000483)2.05016702
71Cerebellar dysplasia (HP:0007033)2.04133454
72Abnormality of the frontal sinuses (HP:0002687)2.03101976
73Truncal obesity (HP:0001956)2.02593628
74Selective tooth agenesis (HP:0001592)1.99704541
75Enlarged penis (HP:0000040)1.98232835
76Increased nuchal translucency (HP:0010880)1.95956777
77Partial agenesis of the corpus callosum (HP:0001338)1.95813264
78Oligodactyly (HP:0012165)1.95770576
79Oligodactyly (hands) (HP:0001180)1.95532707
80Medial flaring of the eyebrow (HP:0010747)1.94737231
81Abnormality of the duodenum (HP:0002246)1.94486218
8211 pairs of ribs (HP:0000878)1.93628913
83Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93500074
84Pendular nystagmus (HP:0012043)1.92041568
85Bony spicule pigmentary retinopathy (HP:0007737)1.91290540
86Volvulus (HP:0002580)1.90928363
87Bifid tongue (HP:0010297)1.90559774
88Capillary hemangiomas (HP:0005306)1.89256259
89Abnormality of the pubic bones (HP:0003172)1.87452778
90Short 4th metacarpal (HP:0010044)1.86976635
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86976635
92Tubular atrophy (HP:0000092)1.84864765
93Squamous cell carcinoma (HP:0002860)1.84555869
94Anal stenosis (HP:0002025)1.83582363
95Germ cell neoplasia (HP:0100728)1.83081337
96Tubulointerstitial nephritis (HP:0001970)1.82285464
97Entropion (HP:0000621)1.81886035
98Lissencephaly (HP:0001339)1.80429261
99Abnormality of ocular smooth pursuit (HP:0000617)1.79961720
100Embryonal neoplasm (HP:0002898)1.79695709
101Birth length less than 3rd percentile (HP:0003561)1.79353154
102Gonadotropin excess (HP:0000837)1.78974814
103Anencephaly (HP:0002323)1.78065647
104Medulloblastoma (HP:0002885)1.77812241
105Dyschromatopsia (HP:0007641)1.77116482
106Deep philtrum (HP:0002002)1.76957306
107Amyotrophic lateral sclerosis (HP:0007354)1.76557990
108Short ribs (HP:0000773)1.76450024
109Short tibia (HP:0005736)1.76240424
110Preaxial hand polydactyly (HP:0001177)1.75965808
111Chronic sinusitis (HP:0011109)1.74642883
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73684647
113Aqueductal stenosis (HP:0002410)1.73165121
114Absent epiphyses (HP:0010577)1.73081252
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73081252
116Sloping forehead (HP:0000340)1.72765111
117Neoplasm of the thyroid gland (HP:0100031)1.71462276
118Transitional cell carcinoma of the bladder (HP:0006740)1.70998508
119Cafe-au-lait spot (HP:0000957)1.70400647
120Tongue fasciculations (HP:0001308)1.70006335
121Abdominal situs inversus (HP:0003363)1.69945114
122Abnormality of abdominal situs (HP:0011620)1.69945114
123Impaired smooth pursuit (HP:0007772)1.69503847
124Abnormality of the septum pellucidum (HP:0007375)1.66867673
125True hermaphroditism (HP:0010459)1.66097829
126Ependymoma (HP:0002888)1.65796234
127High pitched voice (HP:0001620)1.65722366
128Spinal cord lesions (HP:0100561)1.64526887
129Syringomyelia (HP:0003396)1.64526887
130Abnormality of the parathyroid morphology (HP:0011766)1.64229705
131Long toe (HP:0010511)1.63988234
132Abnormality of the labia minora (HP:0012880)1.63940556
133Cystic hygroma (HP:0000476)1.63347810
134Basal cell carcinoma (HP:0002671)1.62932016
135Ectopic kidney (HP:0000086)1.62397001
136Glioma (HP:0009733)1.62149149
137Cleft eyelid (HP:0000625)1.62096613
138Abnormality of the lower motor neuron (HP:0002366)1.60753378
139Prominent nose (HP:0000448)1.60642002
140Abnormality of lateral ventricle (HP:0030047)1.60634313
141Abnormality of cells of the erythroid lineage (HP:0012130)1.58665643
142Papillary thyroid carcinoma (HP:0002895)1.55869944
143Congenital primary aphakia (HP:0007707)1.54278980
144Constricted visual fields (HP:0001133)1.51108841
145Long eyelashes (HP:0000527)1.50291213
146Missing ribs (HP:0000921)1.49652469
147Muscle fibrillation (HP:0010546)1.49450278
148Gait imbalance (HP:0002141)1.49083395
149Postaxial foot polydactyly (HP:0001830)1.47400380
150Abnormal number of erythroid precursors (HP:0012131)1.47381946
151Acute myeloid leukemia (HP:0004808)1.46540093
152Absent frontal sinuses (HP:0002688)1.46492709
153Hemiparesis (HP:0001269)1.46113430
154Abnormality of the fingertips (HP:0001211)1.45960596
155Chronic otitis media (HP:0000389)1.45280976
156Facial cleft (HP:0002006)1.42972363
157Deformed sella turcica (HP:0002681)1.42235955
158Amaurosis fugax (HP:0100576)1.42163023
159Fatigue (HP:0012378)1.40591241
160Absent thumb (HP:0009777)1.39472472
161Abnormality of chromosome stability (HP:0003220)1.39058226
162Type II diabetes mellitus (HP:0005978)1.37852505
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.36758672
164Nephroblastoma (Wilms tumor) (HP:0002667)1.36552145
165Abnormality of the phalanges of the hallux (HP:0010057)1.35710673
166Poikilocytosis (HP:0004447)1.34756986
167Myelodysplasia (HP:0002863)1.34027735
168Neoplasm of the oral cavity (HP:0100649)1.33663987
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.33009984
170Oculomotor apraxia (HP:0000657)1.32950108
171Abnormal rod and cone electroretinograms (HP:0008323)1.31062585
172Neoplasm of striated muscle (HP:0009728)1.30530592
173Attenuation of retinal blood vessels (HP:0007843)1.30444802
174Easy fatigability (HP:0003388)1.30353354
175Duodenal stenosis (HP:0100867)1.30111524
176Small intestinal stenosis (HP:0012848)1.30111524
177Nephrogenic diabetes insipidus (HP:0009806)1.30051046
178Severe visual impairment (HP:0001141)1.29880513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.16273279
2PDK36.16273279
3FRK4.12749365
4TRIM284.04414871
5NEK23.53045874
6PIK3CA3.52857017
7PDK23.51663412
8TESK13.33569173
9PRKD33.32180284
10CDC73.15981013
11ICK3.08067232
12CDK122.94845558
13NEK62.31199691
14BRD42.10676048
15WEE12.07565066
16EEF2K2.06879427
17EIF2AK32.04490336
18DYRK31.90032530
19EPHA21.76085684
20STK101.72838131
21PBK1.71613263
22CHUK1.71153539
23CHEK21.58558483
24ZAK1.47614912
25PASK1.47119900
26MUSK1.46630567
27ERBB41.45176219
28STK391.42555786
29DYRK1B1.39476587
30MAP2K21.38868359
31TTK1.37604829
32TAF11.35324158
33MAP3K101.33583078
34NUAK11.32830353
35WNK31.31380248
36SIK11.26492231
37BCR1.25959533
38CHEK11.24814765
39BUB11.23456571
40TAOK31.22667080
41CDK61.20126373
42PTK2B1.19767814
43CDK41.19041310
44BRSK21.18761299
45EIF2AK21.13911688
46PLK41.13240202
47ATR1.12456582
48MAP4K11.11381142
49PLK11.08248598
50PNCK1.08156173
51STK31.07520846
52ERBB31.07172687
53NEK11.06884414
54MAP4K21.03902795
55EIF2AK11.03381185
56BRSK11.02680663
57STK38L0.96559482
58TYRO30.94533747
59RPS6KB20.94403532
60STK380.94054456
61MAP3K120.91583501
62BMPR1B0.90254798
63RIPK10.89223503
64PIM20.87869265
65CCNB10.86992351
66CDK70.86888515
67ATM0.86321016
68PIM10.86267526
69CDK90.85969883
70FGFR20.84099732
71MAP3K90.83840690
72LATS10.81647099
73AURKB0.81564244
74PDK10.79261761
75MAP2K70.78866186
76CASK0.77678800
77MELK0.76954071
78MAP3K80.75920570
79RPS6KA40.75045264
80TRIB30.70218424
81MAP2K10.68568347
82IKBKB0.66104911
83IKBKE0.65604260
84MAP3K40.64161528
85TESK20.62828859
86WNK40.62480588
87CSNK1A1L0.62357409
88SCYL20.60431327
89ZAP700.59869353
90CDK20.59615643
91VRK20.59122490
92VRK10.57994758
93PRKCI0.56196861
94MTOR0.56062920
95AURKA0.55896404
96IRAK10.55610600
97WNK10.53136011
98GRK60.52787936
99KSR10.51874841
100PRKD20.50362471
101BTK0.50321961
102MAPK130.50279789
103SIK30.50258327
104TLK10.49427434
105CSNK1G10.49184259
106PAK40.48422069
107ITK0.47590603
108STK40.47189649
109SMG10.46430905
110TSSK60.46265650
111CAMK1G0.45994188
112CSF1R0.45621322
113ACVR1B0.44361157
114CSNK1G30.41933669
115RPS6KA10.41335975
116TGFBR20.40629400
117LRRK20.39851821
118PAK10.39499279
119CDK10.38766143
120JAK30.38439943
121HIPK20.38035152
122CSNK1G20.37845411
123ALK0.37515197
124CLK10.36169442
125PRKCZ0.35351011
126CDK80.35307775
127FER0.34761835
128TGFBR10.33940953
129MARK30.33184774
130CSNK1D0.32339753
131MAPKAPK30.30655348
132PKN20.28421116
133CSNK2A20.25934039
134NLK0.25375700
135PRKDC0.25086989
136MAP2K30.24240377
137SRPK10.23733744
138RPS6KB10.23704510
139PAK20.23190620
140YES10.22616004
141MKNK20.21683970
142SYK0.21233356
143PLK30.21068648
144TEC0.19795089
145GSK3B0.19619051
146MAPK10.19247200
147MAPK150.19103410
148STK110.18849921
149RAF10.18740919
150PRKAA10.18340496
151MKNK10.18092929
152MAPK140.17233278

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.12035073
2RNA transport_Homo sapiens_hsa030132.75883472
3Cell cycle_Homo sapiens_hsa041102.51014722
4Basal transcription factors_Homo sapiens_hsa030222.41141236
5Fanconi anemia pathway_Homo sapiens_hsa034602.31094756
6Spliceosome_Homo sapiens_hsa030402.29134074
7mRNA surveillance pathway_Homo sapiens_hsa030152.23916049
8Systemic lupus erythematosus_Homo sapiens_hsa053222.16381288
9Mismatch repair_Homo sapiens_hsa034302.14715994
10Oocyte meiosis_Homo sapiens_hsa041142.12416385
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06917747
12Homologous recombination_Homo sapiens_hsa034401.96441038
13Base excision repair_Homo sapiens_hsa034101.93894730
14Dorso-ventral axis formation_Homo sapiens_hsa043201.83856487
15RNA degradation_Homo sapiens_hsa030181.72624845
16Non-homologous end-joining_Homo sapiens_hsa034501.69637481
17Antigen processing and presentation_Homo sapiens_hsa046121.69530051
18TGF-beta signaling pathway_Homo sapiens_hsa043501.69009202
19Steroid biosynthesis_Homo sapiens_hsa001001.61665334
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57293619
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48584338
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47406789
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41223310
24RNA polymerase_Homo sapiens_hsa030201.41152778
25Viral carcinogenesis_Homo sapiens_hsa052031.40364786
26Butanoate metabolism_Homo sapiens_hsa006501.40139318
27FoxO signaling pathway_Homo sapiens_hsa040681.34936059
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30387031
29Alcoholism_Homo sapiens_hsa050341.30198499
30Melanoma_Homo sapiens_hsa052181.29899243
31Endometrial cancer_Homo sapiens_hsa052131.23781024
32Glucagon signaling pathway_Homo sapiens_hsa049221.23481866
33B cell receptor signaling pathway_Homo sapiens_hsa046621.22024259
34Nucleotide excision repair_Homo sapiens_hsa034201.21695899
35Lysine degradation_Homo sapiens_hsa003101.18981365
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18885444
37One carbon pool by folate_Homo sapiens_hsa006701.18039715
38Fatty acid biosynthesis_Homo sapiens_hsa000611.17353490
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14141835
40N-Glycan biosynthesis_Homo sapiens_hsa005101.13885086
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12070759
42Herpes simplex infection_Homo sapiens_hsa051681.11073317
43* p53 signaling pathway_Homo sapiens_hsa041151.09723010
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09455936
45Regulation of autophagy_Homo sapiens_hsa041401.06913614
46Pentose phosphate pathway_Homo sapiens_hsa000301.06856473
47Purine metabolism_Homo sapiens_hsa002301.05849592
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.02382742
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02336150
50Proteasome_Homo sapiens_hsa030501.02247601
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99281688
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98947690
53Propanoate metabolism_Homo sapiens_hsa006400.98421289
54HTLV-I infection_Homo sapiens_hsa051660.97753665
55Pyrimidine metabolism_Homo sapiens_hsa002400.96671383
56Selenocompound metabolism_Homo sapiens_hsa004500.96574512
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96465116
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94849689
59ErbB signaling pathway_Homo sapiens_hsa040120.94112406
60Prolactin signaling pathway_Homo sapiens_hsa049170.92659802
61VEGF signaling pathway_Homo sapiens_hsa043700.90525528
62Vitamin B6 metabolism_Homo sapiens_hsa007500.90268737
63Epstein-Barr virus infection_Homo sapiens_hsa051690.89316425
64Primary immunodeficiency_Homo sapiens_hsa053400.88007990
65Bladder cancer_Homo sapiens_hsa052190.85086139
66Legionellosis_Homo sapiens_hsa051340.83917702
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83759778
68Ribosome_Homo sapiens_hsa030100.83100882
69Measles_Homo sapiens_hsa051620.82300644
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.80840981
71Hedgehog signaling pathway_Homo sapiens_hsa043400.80101442
72mTOR signaling pathway_Homo sapiens_hsa041500.79936165
73Glioma_Homo sapiens_hsa052140.79717358
74T cell receptor signaling pathway_Homo sapiens_hsa046600.78017781
75Type II diabetes mellitus_Homo sapiens_hsa049300.76037165
76ABC transporters_Homo sapiens_hsa020100.75380595
77Small cell lung cancer_Homo sapiens_hsa052220.74553606
78Estrogen signaling pathway_Homo sapiens_hsa049150.73482025
79Chronic myeloid leukemia_Homo sapiens_hsa052200.72662808
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72423401
81MicroRNAs in cancer_Homo sapiens_hsa052060.72333246
82Inositol phosphate metabolism_Homo sapiens_hsa005620.72142024
83Choline metabolism in cancer_Homo sapiens_hsa052310.71235588
84Nitrogen metabolism_Homo sapiens_hsa009100.68275687
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65551500
86Hepatitis C_Homo sapiens_hsa051600.64100525
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63859895
88Hepatitis B_Homo sapiens_hsa051610.62922396
89Phototransduction_Homo sapiens_hsa047440.62494814
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62328201
91Basal cell carcinoma_Homo sapiens_hsa052170.61850376
92Adherens junction_Homo sapiens_hsa045200.61496306
93Wnt signaling pathway_Homo sapiens_hsa043100.61040027
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60951124
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59726325
96Influenza A_Homo sapiens_hsa051640.59429774
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59083305
98Colorectal cancer_Homo sapiens_hsa052100.58459989
99HIF-1 signaling pathway_Homo sapiens_hsa040660.58282053
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57910249
101Long-term potentiation_Homo sapiens_hsa047200.57798792
102Insulin signaling pathway_Homo sapiens_hsa049100.57435707
103Acute myeloid leukemia_Homo sapiens_hsa052210.57129174
104Insulin resistance_Homo sapiens_hsa049310.57051201
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56927162
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55903978
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55701282
108Renal cell carcinoma_Homo sapiens_hsa052110.55234484
109Mineral absorption_Homo sapiens_hsa049780.54677792
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54346616
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54054349
112Notch signaling pathway_Homo sapiens_hsa043300.52859727
113Toxoplasmosis_Homo sapiens_hsa051450.52456046
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.50347218
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.49706005
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48747096
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48573197
118Osteoclast differentiation_Homo sapiens_hsa043800.48402929
119Sulfur relay system_Homo sapiens_hsa041220.47783129
120Taste transduction_Homo sapiens_hsa047420.47457583
121Non-small cell lung cancer_Homo sapiens_hsa052230.47370716
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.47305533
123Tight junction_Homo sapiens_hsa045300.47238651
124Sphingolipid metabolism_Homo sapiens_hsa006000.46845477
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46090387
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45940981
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44887399
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.44520536
129Thyroid cancer_Homo sapiens_hsa052160.44291006
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43474491
131Pancreatic cancer_Homo sapiens_hsa052120.43054724
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41313738
133AMPK signaling pathway_Homo sapiens_hsa041520.41291752
134Axon guidance_Homo sapiens_hsa043600.40446188
135Circadian rhythm_Homo sapiens_hsa047100.40293848
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40029216
137Hippo signaling pathway_Homo sapiens_hsa043900.39668759
138Linoleic acid metabolism_Homo sapiens_hsa005910.39627227
139Apoptosis_Homo sapiens_hsa042100.38097425
140Protein export_Homo sapiens_hsa030600.38054805
141Nicotine addiction_Homo sapiens_hsa050330.37921244
142Pyruvate metabolism_Homo sapiens_hsa006200.37232780
143Viral myocarditis_Homo sapiens_hsa054160.36737139
144Prostate cancer_Homo sapiens_hsa052150.36508686
145Fructose and mannose metabolism_Homo sapiens_hsa000510.35914754
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.35350738
147Shigellosis_Homo sapiens_hsa051310.35155833

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