PPM1E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.23678788
2locomotory exploration behavior (GO:0035641)5.92357827
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.80966957
4vocalization behavior (GO:0071625)5.78212731
5synaptic vesicle maturation (GO:0016188)5.71590268
6synaptic vesicle exocytosis (GO:0016079)5.47933671
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44151301
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.37352768
9glutamate secretion (GO:0014047)5.26449442
10protein localization to synapse (GO:0035418)5.24041823
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.18982553
12regulation of glutamate receptor signaling pathway (GO:1900449)5.16606583
13pyrimidine nucleobase catabolic process (GO:0006208)5.05075944
14neuron cell-cell adhesion (GO:0007158)5.01006477
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.98029780
16regulation of synaptic vesicle exocytosis (GO:2000300)4.93238590
17exploration behavior (GO:0035640)4.90739676
18glutamate receptor signaling pathway (GO:0007215)4.68719171
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62895239
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.54008868
21regulation of neuronal synaptic plasticity (GO:0048168)4.52466916
22synaptic transmission, glutamatergic (GO:0035249)4.50936122
23regulation of synaptic vesicle transport (GO:1902803)4.45634673
24layer formation in cerebral cortex (GO:0021819)4.26753652
25neuron-neuron synaptic transmission (GO:0007270)4.20403392
26dendritic spine morphogenesis (GO:0060997)4.19973998
27neurotransmitter secretion (GO:0007269)4.18232483
28neurotransmitter-gated ion channel clustering (GO:0072578)4.14701405
29neuronal action potential propagation (GO:0019227)4.10966378
30long-term memory (GO:0007616)4.05063881
31regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03554019
32regulation of synapse structural plasticity (GO:0051823)4.01037038
33neuron recognition (GO:0008038)3.99401932
34nucleobase catabolic process (GO:0046113)3.99222933
35positive regulation of synapse maturation (GO:0090129)3.99180870
36positive regulation of membrane potential (GO:0045838)3.88170080
37regulation of postsynaptic membrane potential (GO:0060078)3.84894717
38cellular potassium ion homeostasis (GO:0030007)3.81908265
39proline transport (GO:0015824)3.80126714
40regulation of dendritic spine morphogenesis (GO:0061001)3.78325814
41innervation (GO:0060384)3.78069124
42regulation of synaptic plasticity (GO:0048167)3.77876014
43long-term synaptic potentiation (GO:0060291)3.70650319
44synaptic vesicle endocytosis (GO:0048488)3.70321062
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.67822492
46axonal fasciculation (GO:0007413)3.64887353
47postsynaptic membrane organization (GO:0001941)3.64059397
48gamma-aminobutyric acid transport (GO:0015812)3.62525137
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59331375
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55934014
51response to histamine (GO:0034776)3.52389790
52auditory behavior (GO:0031223)3.50909893
53presynaptic membrane assembly (GO:0097105)3.49063990
54behavioral fear response (GO:0001662)3.48995355
55behavioral defense response (GO:0002209)3.48995355
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47907930
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46658297
58sodium ion export (GO:0071436)3.45240417
59neurotransmitter transport (GO:0006836)3.44371098
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.44199563
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40979670
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37767432
63cochlea development (GO:0090102)3.36731564
64startle response (GO:0001964)3.35875853
65regulation of neurotransmitter secretion (GO:0046928)3.35667984
66mechanosensory behavior (GO:0007638)3.34638684
67transmission of nerve impulse (GO:0019226)3.34563428
68dendritic spine organization (GO:0097061)3.33524281
69dendrite morphogenesis (GO:0048813)3.31401727
70cell communication by electrical coupling (GO:0010644)3.30916363
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30518804
72regulation of vesicle fusion (GO:0031338)3.29988219
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.29058984
74positive regulation of neurotransmitter secretion (GO:0001956)3.28277615
75activation of protein kinase A activity (GO:0034199)3.28185358
76regulation of dendritic spine development (GO:0060998)3.24119303
77vesicle transport along microtubule (GO:0047496)3.23131319
78positive regulation of dendritic spine development (GO:0060999)3.22791842
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21931037
80fear response (GO:0042596)3.21550352
81learning (GO:0007612)3.20424220
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18245306
83membrane depolarization (GO:0051899)3.18030919
84presynaptic membrane organization (GO:0097090)3.17785472
85chemosensory behavior (GO:0007635)3.17568138
86cerebellar Purkinje cell differentiation (GO:0021702)3.15138764
87behavioral response to nicotine (GO:0035095)3.14067945
88regulation of neurotransmitter levels (GO:0001505)3.11752475
89establishment of mitochondrion localization (GO:0051654)3.11536316
90neuromuscular process controlling balance (GO:0050885)3.11338441
91regulation of synapse maturation (GO:0090128)3.10849509
92response to auditory stimulus (GO:0010996)3.07145159
93synapse assembly (GO:0007416)3.05687514
94social behavior (GO:0035176)3.03881280
95intraspecies interaction between organisms (GO:0051703)3.03881280
96positive regulation of neurotransmitter transport (GO:0051590)3.03743505
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03323261
98regulation of synaptic transmission (GO:0050804)3.03287607
99central nervous system projection neuron axonogenesis (GO:0021952)3.03162526
100regulation of neurotransmitter transport (GO:0051588)3.00999776
101positive regulation of synaptic transmission (GO:0050806)3.00304213
102synaptic transmission (GO:0007268)2.98871959
103membrane depolarization during action potential (GO:0086010)2.98308613
104L-amino acid import (GO:0043092)2.97847805
105membrane hyperpolarization (GO:0060081)2.97660400
106organelle transport along microtubule (GO:0072384)2.94790755
107long term synaptic depression (GO:0060292)2.94647728
108cell migration in hindbrain (GO:0021535)2.91576375
109neuromuscular synaptic transmission (GO:0007274)2.83929542
110apical protein localization (GO:0045176)2.81054625
111cerebellar granule cell differentiation (GO:0021707)2.80043573
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.79673536
113mitochondrion transport along microtubule (GO:0047497)2.79673536
114adult walking behavior (GO:0007628)2.75452048
115neurofilament cytoskeleton organization (GO:0060052)2.63133752
116negative regulation of dendrite development (GO:2000171)2.62418225
117positive regulation of synapse assembly (GO:0051965)2.62191217
118establishment of nucleus localization (GO:0040023)2.62186064
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.61883415
120neuronal ion channel clustering (GO:0045161)2.60035226
121central nervous system neuron axonogenesis (GO:0021955)2.57159522
122synapse organization (GO:0050808)2.56818394
123regulation of respiratory system process (GO:0044065)2.55481682
124axon cargo transport (GO:0008088)2.50564423
125regulation of respiratory gaseous exchange (GO:0043576)2.49811815
126behavioral response to cocaine (GO:0048148)2.46971733
127retinal ganglion cell axon guidance (GO:0031290)2.44590483
128cAMP-mediated signaling (GO:0019933)2.42970471
129axon extension (GO:0048675)2.42316790
130adult behavior (GO:0030534)2.41895970
131regulation of feeding behavior (GO:0060259)2.41783627
132cerebral cortex radially oriented cell migration (GO:0021799)2.40892114
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37914935
134adult locomotory behavior (GO:0008344)2.36508597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.38985785
2GBX2_23144817_ChIP-Seq_PC3_Human3.89051162
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14799169
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10854664
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01923463
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.72670912
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63559365
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63559365
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62160373
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58938774
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50540302
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.48103857
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46915348
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.46369173
15DROSHA_22980978_ChIP-Seq_HELA_Human2.46258322
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43714317
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39066273
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.20720839
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.19331292
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.18171774
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17600276
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17167416
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.15936532
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09534429
25AR_21572438_ChIP-Seq_LNCaP_Human1.93234115
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89649894
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89063247
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87132982
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85671426
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85333003
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85192743
32SMAD4_21799915_ChIP-Seq_A2780_Human1.79887526
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79871559
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77133285
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72836774
36TAF15_26573619_Chip-Seq_HEK293_Human1.71529695
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61678253
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59342500
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57649007
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56622589
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.56480728
42P300_19829295_ChIP-Seq_ESCs_Human1.53766614
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.52765753
44ZNF274_21170338_ChIP-Seq_K562_Hela1.50114513
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.39801796
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39467073
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39288006
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.38893831
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37080586
50EWS_26573619_Chip-Seq_HEK293_Human1.37054409
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35856813
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35823744
53AR_25329375_ChIP-Seq_VCAP_Human1.35612033
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35094701
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30884025
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.30245594
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30240087
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30206369
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29906590
60IGF1R_20145208_ChIP-Seq_DFB_Human1.29785867
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.29429654
62STAT3_23295773_ChIP-Seq_U87_Human1.27915613
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.27683364
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27163824
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26138657
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24529867
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23854287
68FUS_26573619_Chip-Seq_HEK293_Human1.23786865
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23015538
70AR_19668381_ChIP-Seq_PC3_Human1.22782471
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.21203752
72SOX9_26525672_Chip-Seq_HEART_Mouse1.19225810
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18500195
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18497098
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18267309
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.16756768
77TCF4_23295773_ChIP-Seq_U87_Human1.16069709
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14861187
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12970398
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12912444
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12908735
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12012047
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11999899
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10861682
85* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10837646
86TP53_16413492_ChIP-PET_HCT116_Human1.10246108
87* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09370952
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08863135
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08564115
90* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08472861
91RNF2_27304074_Chip-Seq_NSC_Mouse1.07856430
92AHR_22903824_ChIP-Seq_MCF-7_Human1.06545246
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05866558
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05390385
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04484579
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04090434
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02698557
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02239915
99RUNX2_22187159_ChIP-Seq_PCA_Human1.00910842
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00506450
101JUN_21703547_ChIP-Seq_K562_Human1.00149077
102* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00144087
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99938609
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.99642687
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99218615
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99052398
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98661500
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98661500
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.97567773
110BCAT_22108803_ChIP-Seq_LS180_Human0.96185881
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95794842
112TP53_18474530_ChIP-ChIP_U2OS_Human0.95490721
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95437728
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95100803
115POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.94683087
116VDR_22108803_ChIP-Seq_LS180_Human0.94576384
117* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94004142
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.93721045
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93590258
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92481063
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.90470516
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90196902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.12231147
2MP0003880_abnormal_central_pattern5.34077220
3MP0003635_abnormal_synaptic_transmissio4.29171060
4MP0004270_analgesia3.92903979
5MP0002063_abnormal_learning/memory/cond3.50940890
6MP0009745_abnormal_behavioral_response3.42846356
7MP0002064_seizures3.15908731
8MP0001968_abnormal_touch/_nociception3.02523297
9MP0002572_abnormal_emotion/affect_behav2.87358628
10MP0009046_muscle_twitch2.73959004
11MP0005423_abnormal_somatic_nervous2.73111929
12MP0002734_abnormal_mechanical_nocicepti2.59058891
13MP0001486_abnormal_startle_reflex2.56037303
14MP0002272_abnormal_nervous_system2.52549239
15MP0002735_abnormal_chemical_nociception2.40126215
16MP0002736_abnormal_nociception_after2.38082717
17MP0001501_abnormal_sleep_pattern2.20349130
18MP0009780_abnormal_chondrocyte_physiolo2.13850540
19MP0001440_abnormal_grooming_behavior2.13608843
20MP0003123_paternal_imprinting2.10914975
21MP0000778_abnormal_nervous_system2.02838773
22MP0003121_genomic_imprinting1.97169919
23MP0002067_abnormal_sensory_capabilities1.95367585
24MP0002733_abnormal_thermal_nociception1.89190889
25MP0002184_abnormal_innervation1.88310718
26MP0001970_abnormal_pain_threshold1.85808646
27MP0003329_amyloid_beta_deposits1.82831872
28MP0004811_abnormal_neuron_physiology1.81173339
29MP0004858_abnormal_nervous_system1.76080849
30MP0002822_catalepsy1.75999138
31MP0008569_lethality_at_weaning1.75166965
32MP0003787_abnormal_imprinting1.74433253
33MP0002557_abnormal_social/conspecific_i1.70695108
34MP0003283_abnormal_digestive_organ1.67812059
35MP0004924_abnormal_behavior1.65279392
36MP0005386_behavior/neurological_phenoty1.65279392
37MP0002909_abnormal_adrenal_gland1.62420503
38MP0003879_abnormal_hair_cell1.54584337
39MP0000955_abnormal_spinal_cord1.54277588
40MP0006276_abnormal_autonomic_nervous1.53997246
41MP0004885_abnormal_endolymph1.50489646
42MP0001984_abnormal_olfaction1.50007286
43MP0008877_abnormal_DNA_methylation1.49396909
44MP0002882_abnormal_neuron_morphology1.48514519
45MP0005646_abnormal_pituitary_gland1.45116777
46MP0006292_abnormal_olfactory_placode1.42366793
47MP0000566_synostosis1.41737595
48MP0002066_abnormal_motor_capabilities/c1.39844218
49MP0003633_abnormal_nervous_system1.29134186
50MP0005551_abnormal_eye_electrophysiolog1.29078275
51MP0001502_abnormal_circadian_rhythm1.25569295
52MP0001188_hyperpigmentation1.23450204
53MP0005645_abnormal_hypothalamus_physiol1.20828574
54MP0001905_abnormal_dopamine_level1.20579699
55MP0000537_abnormal_urethra_morphology1.16210691
56MP0002152_abnormal_brain_morphology1.15499404
57MP0001529_abnormal_vocalization1.15093616
58MP0004142_abnormal_muscle_tone1.12346796
59MP0003890_abnormal_embryonic-extraembry1.11973391
60MP0003119_abnormal_digestive_system1.10925543
61MP0003631_nervous_system_phenotype1.10733024
62MP0000569_abnormal_digit_pigmentation1.09959824
63MP0004133_heterotaxia1.09666816
64MP0002837_dystrophic_cardiac_calcinosis1.08575117
65MP0000751_myopathy1.05010071
66MP0002751_abnormal_autonomic_nervous1.01699868
67MP0003122_maternal_imprinting1.01466287
68MP0002229_neurodegeneration1.01046488
69MP0003937_abnormal_limbs/digits/tail_de0.99792921
70MP0004215_abnormal_myocardial_fiber0.97155040
71MP0003938_abnormal_ear_development0.94548410
72MP0004145_abnormal_muscle_electrophysio0.93059144
73MP0002938_white_spotting0.92854972
74MP0002069_abnormal_eating/drinking_beha0.90420944
75MP0004484_altered_response_of0.89956239
76MP0001963_abnormal_hearing_physiology0.88416811
77MP0003315_abnormal_perineum_morphology0.88027351
78MP0004085_abnormal_heartbeat0.87699122
79MP0002102_abnormal_ear_morphology0.87172049
80MP0003942_abnormal_urinary_system0.85614931
81MP0001293_anophthalmia0.84748298
82MP0008874_decreased_physiological_sensi0.83873791
83MP0002752_abnormal_somatic_nervous0.83022432
84MP0001346_abnormal_lacrimal_gland0.82750739
85MP0004742_abnormal_vestibular_system0.82648687
86MP0000049_abnormal_middle_ear0.82296189
87MP0003634_abnormal_glial_cell0.82276164
88MP0004510_myositis0.81848658
89MP0002090_abnormal_vision0.81636769
90MP0010386_abnormal_urinary_bladder0.81511610
91MP0001177_atelectasis0.81427939
92MP0008872_abnormal_physiological_respon0.80445703
93MP0005499_abnormal_olfactory_system0.80434335
94MP0005394_taste/olfaction_phenotype0.80434335
95MP0003136_yellow_coat_color0.79845020
96MP0002233_abnormal_nose_morphology0.78149331
97MP0002653_abnormal_ependyma_morphology0.77319739
98MP0002081_perinatal_lethality0.77105963
99MP0003632_abnormal_nervous_system0.76576680
100MP0000604_amyloidosis0.76481462
101MP0000631_abnormal_neuroendocrine_gland0.75916596
102MP0003698_abnormal_male_reproductive0.74373941
103MP0003075_altered_response_to0.73268618
104MP0005409_darkened_coat_color0.73217047
105MP0004233_abnormal_muscle_weight0.73213782
106MP0005535_abnormal_body_temperature0.72922944
107MP0002697_abnormal_eye_size0.72177497
108MP0009672_abnormal_birth_weight0.71075124
109MP0001299_abnormal_eye_distance/0.71062069
110MP0002249_abnormal_larynx_morphology0.70144768
111MP0003137_abnormal_impulse_conducting0.69267311
112MP0000534_abnormal_ureter_morphology0.69136882
113MP0002082_postnatal_lethality0.67645168
114MP0006072_abnormal_retinal_apoptosis0.65486459
115MP0001485_abnormal_pinna_reflex0.65202373
116MP0000920_abnormal_myelination0.65201396
117MP0003690_abnormal_glial_cell0.64688139
118MP0003861_abnormal_nervous_system0.64646532
119MP0002876_abnormal_thyroid_physiology0.64616313
120MP0000013_abnormal_adipose_tissue0.63985343
121MP0008961_abnormal_basal_metabolism0.63504177
122MP0001664_abnormal_digestion0.61794781
123MP0005187_abnormal_penis_morphology0.61575328
124MP0005253_abnormal_eye_physiology0.55878999
125MP0001943_abnormal_respiration0.54576058
126MP0002638_abnormal_pupillary_reflex0.53827564
127MP0010769_abnormal_survival0.53647227
128MP0000026_abnormal_inner_ear0.53255938
129MP0002234_abnormal_pharynx_morphology0.52647625
130MP0004130_abnormal_muscle_cell0.52525591
131MP0010770_preweaning_lethality0.51934025

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.12327130
2Myokymia (HP:0002411)6.66042240
3Focal seizures (HP:0007359)5.78600016
4Visual hallucinations (HP:0002367)5.32519287
5Epileptic encephalopathy (HP:0200134)5.21868085
6Febrile seizures (HP:0002373)4.71824075
7Atonic seizures (HP:0010819)4.68371345
8Progressive cerebellar ataxia (HP:0002073)4.58756647
9Absence seizures (HP:0002121)4.47819442
10Hyperventilation (HP:0002883)4.11539724
11Dialeptic seizures (HP:0011146)4.08589651
12Generalized tonic-clonic seizures (HP:0002069)3.96376339
13Broad-based gait (HP:0002136)3.74306784
14Supranuclear gaze palsy (HP:0000605)3.69150409
15Action tremor (HP:0002345)3.53507183
16Amblyopia (HP:0000646)3.27182069
17Poor eye contact (HP:0000817)3.26593307
18Impaired vibration sensation in the lower limbs (HP:0002166)3.26452735
19Gaze-evoked nystagmus (HP:0000640)3.22823144
20Excessive salivation (HP:0003781)3.22052437
21Drooling (HP:0002307)3.22052437
22Abnormality of the labia minora (HP:0012880)3.18552538
23Mutism (HP:0002300)3.16047919
24Truncal ataxia (HP:0002078)3.14700521
25Depression (HP:0000716)3.12322481
26Hepatoblastoma (HP:0002884)3.07367671
27Dysmetria (HP:0001310)3.06971327
28Dysdiadochokinesis (HP:0002075)3.04965237
29Papilledema (HP:0001085)3.04235484
30Impaired social interactions (HP:0000735)2.98498486
31Abnormal social behavior (HP:0012433)2.98498486
32Urinary bladder sphincter dysfunction (HP:0002839)2.96863553
33Genetic anticipation (HP:0003743)2.92075554
34Ankle clonus (HP:0011448)2.91802170
35Postural instability (HP:0002172)2.91227452
36Anxiety (HP:0000739)2.88232841
37Progressive inability to walk (HP:0002505)2.85003500
38Cerebral inclusion bodies (HP:0100314)2.83843113
39Epileptiform EEG discharges (HP:0011182)2.81308731
40Abnormality of the lower motor neuron (HP:0002366)2.78508937
41Volvulus (HP:0002580)2.76335433
42Diplopia (HP:0000651)2.72882043
43Abnormality of binocular vision (HP:0011514)2.72882043
44Absent speech (HP:0001344)2.72534245
45Abnormal eating behavior (HP:0100738)2.70975845
46Impaired smooth pursuit (HP:0007772)2.63155385
47Neurofibrillary tangles (HP:0002185)2.63067428
48Hemiparesis (HP:0001269)2.58780899
49EEG with generalized epileptiform discharges (HP:0011198)2.54761396
50Stereotypic behavior (HP:0000733)2.48664072
51Urinary urgency (HP:0000012)2.48426560
52Bradykinesia (HP:0002067)2.45534455
53Inability to walk (HP:0002540)2.43583777
54Hypsarrhythmia (HP:0002521)2.38354813
55Insidious onset (HP:0003587)2.37445658
56Termporal pattern (HP:0011008)2.37445658
57Spastic gait (HP:0002064)2.33480801
58Megalencephaly (HP:0001355)2.32912174
59Abnormality of ocular smooth pursuit (HP:0000617)2.28594437
60Fetal akinesia sequence (HP:0001989)2.28536402
61Inappropriate behavior (HP:0000719)2.27151261
62Amyotrophic lateral sclerosis (HP:0007354)2.26748410
63Intention tremor (HP:0002080)2.26379301
64Scanning speech (HP:0002168)2.22707845
65Generalized myoclonic seizures (HP:0002123)2.22614798
66Impaired vibratory sensation (HP:0002495)2.20611699
67Torticollis (HP:0000473)2.20361066
68Focal dystonia (HP:0004373)2.19364988
69Cortical dysplasia (HP:0002539)2.19233217
70Abnormality of the corticospinal tract (HP:0002492)2.19174480
71Abnormality of salivation (HP:0100755)2.17333541
72Oligodactyly (hands) (HP:0001180)2.16485498
73Pheochromocytoma (HP:0002666)2.12512582
74Ventricular fibrillation (HP:0001663)2.11357766
75Hemiplegia (HP:0002301)2.07069936
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.06693693
77Blue irides (HP:0000635)2.05827495
78Lower limb muscle weakness (HP:0007340)2.05153341
79Protruding tongue (HP:0010808)2.04006145
80Polyphagia (HP:0002591)2.03136043
81High anterior hairline (HP:0009890)2.01407479
82Dysmetric saccades (HP:0000641)2.00847932
83Agitation (HP:0000713)1.96600791
84Status epilepticus (HP:0002133)1.96575315
85Sleep apnea (HP:0010535)1.96154512
86Aqueductal stenosis (HP:0002410)1.95117285
87Cutaneous finger syndactyly (HP:0010554)1.91548119
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90356718
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.90356718
90Incomplete penetrance (HP:0003829)1.90002297
91Gait ataxia (HP:0002066)1.89796294
92Hypoglycemic seizures (HP:0002173)1.87744618
93Delusions (HP:0000746)1.87586555
94Obstructive sleep apnea (HP:0002870)1.87486142
95Oligodactyly (HP:0012165)1.87332007
96Insomnia (HP:0100785)1.86885400
97Lower limb asymmetry (HP:0100559)1.86399175
98Neuroendocrine neoplasm (HP:0100634)1.84298916
99Limb dystonia (HP:0002451)1.83550798
100Rapidly progressive (HP:0003678)1.81926508
101Akinesia (HP:0002304)1.81512130
102Widely spaced teeth (HP:0000687)1.80297165
103Craniofacial dystonia (HP:0012179)1.79825786
104Psychosis (HP:0000709)1.78568831
105Pointed chin (HP:0000307)1.78159804
106Abnormality of the metopic suture (HP:0005556)1.76019663
107Gait imbalance (HP:0002141)1.75604520
108Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74898767
109Thickened helices (HP:0000391)1.74216278
110Failure to thrive in infancy (HP:0001531)1.73583159
111Abnormal EKG (HP:0003115)1.73550161
112Lower limb amyotrophy (HP:0007210)1.73110582
113Apathy (HP:0000741)1.72121701
114Sacral dimple (HP:0000960)1.71040260
115Morphological abnormality of the pyramidal tract (HP:0002062)1.70664956
116Exotropia (HP:0000577)1.70536960
117Autism (HP:0000717)1.69484297
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69316661
119Esophageal atresia (HP:0002032)1.67751790
120Obsessive-compulsive behavior (HP:0000722)1.67621042
121Poor suck (HP:0002033)1.67590690
122Cutaneous syndactyly (HP:0012725)1.66425819
123Impulsivity (HP:0100710)1.65278008
124Intestinal atresia (HP:0011100)1.64438795
125Spastic tetraplegia (HP:0002510)1.63050929
126Hyperinsulinemic hypoglycemia (HP:0000825)1.59265660
127Narrow forehead (HP:0000341)1.59202396
128Increased nuchal translucency (HP:0010880)1.58881007
129Truncal obesity (HP:0001956)1.58664203
130Septo-optic dysplasia (HP:0100842)1.58097906
131Colon cancer (HP:0003003)1.56632212
132Abnormality of the aortic arch (HP:0012303)1.56390110
133Genital tract atresia (HP:0001827)1.53883605
134Optic nerve hypoplasia (HP:0000609)1.53298893
135Specific learning disability (HP:0001328)1.52359400
136Short 4th metacarpal (HP:0010044)1.52159398
137Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.52159398
138Renal hypoplasia (HP:0000089)1.51546348
139Abnormal hair whorl (HP:0010721)1.50509702
140Nephronophthisis (HP:0000090)1.49456070
141Abnormal lung lobation (HP:0002101)1.49111566
142Gastrointestinal atresia (HP:0002589)1.49029061
143Vaginal atresia (HP:0000148)1.48775175
144Supernumerary spleens (HP:0009799)1.47930997
145Neoplasm of the oral cavity (HP:0100649)1.47140509
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.45547508
147Neoplasm of the adrenal cortex (HP:0100641)1.45369265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.79727106
2EPHA44.39018855
3MARK13.74780764
4MAP3K93.62289851
5MAP3K43.12412485
6MINK12.79865135
7MAP2K72.73162932
8RIPK42.16557833
9DAPK22.16511818
10PAK62.11241192
11MAP3K122.06733235
12NTRK22.02737300
13CASK2.01206402
14KSR21.94082841
15MAP2K41.92145777
16CAMK1D1.86544318
17KSR11.82784221
18PRKD31.78239602
19DAPK11.76997731
20DYRK21.76269482
21PLK21.71977615
22CAMKK11.62085891
23PNCK1.59799437
24TNIK1.57807930
25CDK51.56343000
26NTRK11.49199802
27SIK21.47975736
28MAPK131.47734274
29GRK51.46902555
30PRPF4B1.33218404
31PRKCG1.28941914
32STK381.23446513
33BRD41.23112122
34FES1.20274837
35MKNK21.20233751
36CDK191.18033155
37CDC71.16071593
38CAMK2A1.13665628
39MAP3K21.09656527
40CAMK2B1.03954987
41PHKG11.03909982
42PHKG21.03909982
43LATS21.00562123
44FGFR20.99753702
45UHMK10.99691275
46ARAF0.98667427
47PTK2B0.97907221
48TTK0.96666484
49CSNK1G10.94285533
50CAMK10.93143599
51WEE10.92192509
52PLK40.92101482
53NME10.91710225
54CSNK1G30.91634938
55CDK180.90427965
56BMPR20.88751921
57PLK30.88656303
58MAP3K130.88505337
59TYRO30.87954642
60CDK150.87417760
61CDK140.84952183
62SRPK10.84946095
63RAF10.83788824
64MKNK10.83326344
65PAK30.81725444
66DYRK1A0.81157709
67STK110.80857735
68SGK2230.75856940
69SGK4940.75856940
70CDK11A0.75730888
71BUB10.75705969
72CSNK1G20.75460389
73BRSK10.73995319
74RET0.73307506
75EPHB20.73077356
76SGK10.71210682
77PDK10.69955468
78CSNK1E0.68800174
79CDK30.67770705
80SGK20.67407223
81CSNK1A1L0.66938180
82PRKCH0.66809712
83TRIM280.65941968
84STK390.65010549
85PASK0.64803174
86FGR0.63847965
87CAMKK20.62357859
88MARK20.62280239
89OXSR10.61530378
90FRK0.60844532
91MAP3K70.59494501
92PLK10.59255965
93BRAF0.58735873
94CAMK1G0.58227009
95TAOK10.57811902
96MAP3K60.57274112
97PRKDC0.56406763
98CSNK1D0.56077974
99PRKCZ0.55855392
100SGK30.55114780
101LMTK20.54910698
102WNK40.54025808
103ALK0.53542191
104CAMK2D0.53337795
105ATM0.52802130
106PRKCE0.52619229
107ATR0.51351070
108GSK3B0.51171392
109PINK10.51107160
110PDPK10.50945102
111TSSK60.50405021
112FER0.50371895
113DMPK0.50283955
114FYN0.47797653
115RPS6KA30.47631924
116SCYL20.46855482
117AURKA0.46117812
118CDK10.45365681
119PRKAA10.44419643
120DYRK30.44173181
121CHEK20.42376124
122CDK20.42199585
123CCNB10.41824901
124MAPK100.41600644
125CDC42BPA0.41445015
126AKT30.40600459
127TNK20.39887105
128MAP3K10.39336413
129MAPK120.39072882
130MAP2K10.37105613
131SIK30.37044241
132PKN10.37011783
133ROCK20.36176380
134CAMK2G0.35501623
135PRKCB0.34566103
136CAMK40.34520259
137BCR0.33003517
138WNK30.32595554
139ERBB30.31550924

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.90146794
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04431279
3Long-term potentiation_Homo sapiens_hsa047202.95411108
4Circadian entrainment_Homo sapiens_hsa047132.82019129
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75039614
6Glutamatergic synapse_Homo sapiens_hsa047242.68887003
7Olfactory transduction_Homo sapiens_hsa047402.65142949
8GABAergic synapse_Homo sapiens_hsa047272.64739783
9Amphetamine addiction_Homo sapiens_hsa050312.54113155
10Morphine addiction_Homo sapiens_hsa050322.44253823
11Salivary secretion_Homo sapiens_hsa049702.27580028
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27531126
13Dopaminergic synapse_Homo sapiens_hsa047282.19346247
14Insulin secretion_Homo sapiens_hsa049111.97932456
15Gastric acid secretion_Homo sapiens_hsa049711.94207430
16Cholinergic synapse_Homo sapiens_hsa047251.88050290
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87664745
18Long-term depression_Homo sapiens_hsa047301.77747938
19Renin secretion_Homo sapiens_hsa049241.73271687
20Oxytocin signaling pathway_Homo sapiens_hsa049211.71267679
21Serotonergic synapse_Homo sapiens_hsa047261.69642973
22Taste transduction_Homo sapiens_hsa047421.68952735
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66247717
24Calcium signaling pathway_Homo sapiens_hsa040201.64920144
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51650495
26GnRH signaling pathway_Homo sapiens_hsa049121.50063927
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45236516
28Phototransduction_Homo sapiens_hsa047441.39030236
29Cocaine addiction_Homo sapiens_hsa050301.37363299
30Collecting duct acid secretion_Homo sapiens_hsa049661.37172536
31Gap junction_Homo sapiens_hsa045401.31346601
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31308087
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31161315
34Glioma_Homo sapiens_hsa052141.28316863
35cAMP signaling pathway_Homo sapiens_hsa040241.27587963
36Axon guidance_Homo sapiens_hsa043601.23820120
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22981561
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17663254
39Vitamin B6 metabolism_Homo sapiens_hsa007501.17624736
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.16839941
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15024821
42Estrogen signaling pathway_Homo sapiens_hsa049151.14469513
43Steroid biosynthesis_Homo sapiens_hsa001001.13746497
44Type II diabetes mellitus_Homo sapiens_hsa049301.13702591
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11053452
46Melanogenesis_Homo sapiens_hsa049161.08845124
47ErbB signaling pathway_Homo sapiens_hsa040121.07910191
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01411090
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00658522
50Cardiac muscle contraction_Homo sapiens_hsa042601.00391995
51Butanoate metabolism_Homo sapiens_hsa006500.98240232
52Fatty acid biosynthesis_Homo sapiens_hsa000610.97418422
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.96335734
54Hedgehog signaling pathway_Homo sapiens_hsa043400.94144523
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93725189
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93503534
57Hippo signaling pathway_Homo sapiens_hsa043900.90942888
58Oocyte meiosis_Homo sapiens_hsa041140.90681645
59Basal cell carcinoma_Homo sapiens_hsa052170.89949065
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88991361
61Vibrio cholerae infection_Homo sapiens_hsa051100.88741938
62Pancreatic secretion_Homo sapiens_hsa049720.86617374
63Cell cycle_Homo sapiens_hsa041100.85886288
64Oxidative phosphorylation_Homo sapiens_hsa001900.85613304
65Non-homologous end-joining_Homo sapiens_hsa034500.81447573
66Dorso-ventral axis formation_Homo sapiens_hsa043200.80565078
67Parkinsons disease_Homo sapiens_hsa050120.80007822
68Choline metabolism in cancer_Homo sapiens_hsa052310.79501212
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.78506631
70VEGF signaling pathway_Homo sapiens_hsa043700.78117384
71Thyroid hormone synthesis_Homo sapiens_hsa049180.77281006
72Basal transcription factors_Homo sapiens_hsa030220.74871338
73mRNA surveillance pathway_Homo sapiens_hsa030150.74211431
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73168098
75Dilated cardiomyopathy_Homo sapiens_hsa054140.72645494
76MAPK signaling pathway_Homo sapiens_hsa040100.71184730
77Huntingtons disease_Homo sapiens_hsa050160.68526115
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68145334
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67405241
80Fanconi anemia pathway_Homo sapiens_hsa034600.64450759
81Glucagon signaling pathway_Homo sapiens_hsa049220.64159173
82Ras signaling pathway_Homo sapiens_hsa040140.63952643
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.60338951
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60158607
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59614455
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58586747
87Rap1 signaling pathway_Homo sapiens_hsa040150.58510687
88African trypanosomiasis_Homo sapiens_hsa051430.57531471
89mTOR signaling pathway_Homo sapiens_hsa041500.57113419
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55453942
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.54960348
92Alcoholism_Homo sapiens_hsa050340.50609351
93Alzheimers disease_Homo sapiens_hsa050100.49949819
94RNA transport_Homo sapiens_hsa030130.49432305
95Wnt signaling pathway_Homo sapiens_hsa043100.49282565
96Non-small cell lung cancer_Homo sapiens_hsa052230.48454719
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47636741
98Inositol phosphate metabolism_Homo sapiens_hsa005620.47564742
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47046579
100Nitrogen metabolism_Homo sapiens_hsa009100.46369141
101Endometrial cancer_Homo sapiens_hsa052130.45062478
102AMPK signaling pathway_Homo sapiens_hsa041520.44547023
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42834035
104Type I diabetes mellitus_Homo sapiens_hsa049400.42054357
105Endocytosis_Homo sapiens_hsa041440.42009724
106Tight junction_Homo sapiens_hsa045300.40758967
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40754100
108Lysine degradation_Homo sapiens_hsa003100.40336575
109Renal cell carcinoma_Homo sapiens_hsa052110.39960214
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38903616
111Circadian rhythm_Homo sapiens_hsa047100.38871864
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38858351
113RNA degradation_Homo sapiens_hsa030180.38109599
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37763064
115Selenocompound metabolism_Homo sapiens_hsa004500.37073919
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36053318
117Insulin signaling pathway_Homo sapiens_hsa049100.35636158
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34987961
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34987891
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34946714
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34421105
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32813234
123Bile secretion_Homo sapiens_hsa049760.32396436
124Prion diseases_Homo sapiens_hsa050200.31883649
125Colorectal cancer_Homo sapiens_hsa052100.31600097
126Ovarian steroidogenesis_Homo sapiens_hsa049130.30733536
127Chemokine signaling pathway_Homo sapiens_hsa040620.27723435
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27001823
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26548993

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