PPM1F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.98798555
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.60106458
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.60106458
4modulation by symbiont of host immune response (GO:0052553)5.60106458
5positive regulation by symbiont of host defense response (GO:0052509)5.60106458
6modulation by symbiont of host defense response (GO:0052031)5.60106458
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.60106458
8negative regulation of erythrocyte differentiation (GO:0045647)5.41214251
9negative regulation of cell killing (GO:0031342)5.32900377
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.32900377
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15336627
12response to peptidoglycan (GO:0032494)4.98707639
13regulation of translational termination (GO:0006449)4.92678545
14neutrophil activation involved in immune response (GO:0002283)4.76786203
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73830301
16antigen processing and presentation of endogenous antigen (GO:0019883)4.72011489
17detection of other organism (GO:0098543)4.58251819
18cellular extravasation (GO:0045123)4.57432410
19detection of bacterium (GO:0016045)4.31154943
20macrophage activation involved in immune response (GO:0002281)4.30717061
21regulation of B cell receptor signaling pathway (GO:0050855)4.28582484
22regulation of gamma-delta T cell activation (GO:0046643)4.25820015
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23233357
24negative regulation of cell size (GO:0045792)4.03545070
25detection of molecule of bacterial origin (GO:0032490)4.00096767
26regulation of gamma-delta T cell differentiation (GO:0045586)3.99720002
27negative regulation of interleukin-12 production (GO:0032695)3.98657003
28detection of external biotic stimulus (GO:0098581)3.98421059
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96787094
30regulation of mast cell degranulation (GO:0043304)3.96784004
31response to muramyl dipeptide (GO:0032495)3.92385107
32positive regulation of B cell differentiation (GO:0045579)3.85854001
33protein localization to endosome (GO:0036010)3.83927607
34regulation of translational fidelity (GO:0006450)3.78050799
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.77602657
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.75087951
37response to host immune response (GO:0052572)3.75087951
38regulation of myeloid leukocyte mediated immunity (GO:0002886)3.74843341
39regulation of leukocyte degranulation (GO:0043300)3.73482876
40plasma membrane repair (GO:0001778)3.73165974
41regulation of interferon-beta biosynthetic process (GO:0045357)3.70189465
42leukocyte aggregation (GO:0070486)3.69096421
43neutrophil activation (GO:0042119)3.68824395
44adherens junction assembly (GO:0034333)3.67774833
45regulation of mast cell activation involved in immune response (GO:0033006)3.65371392
46leukocyte migration involved in inflammatory response (GO:0002523)3.62412603
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61380114
48positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.58622757
49detection of biotic stimulus (GO:0009595)3.57193410
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.56524472
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.56464514
52response to host (GO:0075136)3.56464514
53response to host defenses (GO:0052200)3.56464514
54response to interleukin-15 (GO:0070672)3.46683712
55respiratory burst (GO:0045730)3.46449088
56B cell receptor signaling pathway (GO:0050853)3.46142965
57pentose-phosphate shunt (GO:0006098)3.42100814
58germinal center formation (GO:0002467)3.41515325
59synaptic vesicle maturation (GO:0016188)3.38933248
60dicarboxylic acid biosynthetic process (GO:0043650)3.38535220
61immunoglobulin mediated immune response (GO:0016064)3.38382742
62regulation of B cell differentiation (GO:0045577)3.37838272
63macrophage activation (GO:0042116)3.37635792
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37315625
65positive thymic T cell selection (GO:0045059)3.36578860
66negative regulation of leukocyte mediated immunity (GO:0002704)3.36365969
67negative regulation of phagocytosis (GO:0050765)3.36134553
68peptidyl-lysine dimethylation (GO:0018027)3.34897891
69granulocyte activation (GO:0036230)3.34653283
70antigen processing and presentation via MHC class Ib (GO:0002475)3.31462336
71myeloid cell activation involved in immune response (GO:0002275)3.31346712
72regulation of mast cell activation (GO:0033003)3.30487371
73lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29837033
74stress fiber assembly (GO:0043149)3.28891268
75vascular endothelial growth factor signaling pathway (GO:0038084)3.26517340
76establishment of nucleus localization (GO:0040023)3.25648987
77positive regulation of mast cell activation (GO:0033005)3.24018378
78cell-substrate adherens junction assembly (GO:0007045)3.22002823
79focal adhesion assembly (GO:0048041)3.22002823
80activation of protein kinase A activity (GO:0034199)3.21180777
81negative regulation of T cell mediated immunity (GO:0002710)3.19706041
82regulation of regulated secretory pathway (GO:1903305)3.18448897
83mannose metabolic process (GO:0006013)3.16110735
84endothelial tube morphogenesis (GO:0061154)3.14923149
85morphogenesis of an endothelium (GO:0003159)3.14923149
86regulation of fatty acid beta-oxidation (GO:0031998)3.14919908
87leukocyte degranulation (GO:0043299)3.14181419
88neutrophil mediated immunity (GO:0002446)3.07159036
89blood vessel endothelial cell migration (GO:0043534)3.06237463
90alpha-linolenic acid metabolic process (GO:0036109)3.01717187
91NADPH regeneration (GO:0006740)3.00804095
92microglial cell activation (GO:0001774)3.00381755
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99847238
94mitotic G1 DNA damage checkpoint (GO:0031571)2.99578748
95negative regulation of interleukin-6 production (GO:0032715)2.98843064
96positive regulation of histone deacetylation (GO:0031065)2.96615343
97negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.94555130
98endothelium development (GO:0003158)2.93214462
99locomotory exploration behavior (GO:0035641)2.92398017
100cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92045619
101cell migration involved in sprouting angiogenesis (GO:0002042)2.91405401
102pre-miRNA processing (GO:0031054)2.89277861
103layer formation in cerebral cortex (GO:0021819)2.88826763
104positive regulation of mast cell activation involved in immune response (GO:0033008)2.86677398
105positive regulation of mast cell degranulation (GO:0043306)2.86677398
106positive regulation of Rap GTPase activity (GO:0032854)2.85333436
107DNA unwinding involved in DNA replication (GO:0006268)2.85113661
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83734796
109NLS-bearing protein import into nucleus (GO:0006607)2.83393710
110sodium ion export (GO:0071436)2.82690374
111basement membrane organization (GO:0071711)2.82268963
112negative regulation of fibrinolysis (GO:0051918)2.81732501
113folic acid-containing compound biosynthetic process (GO:0009396)2.80413749
114cellular response to interleukin-15 (GO:0071350)2.80196400
1152-oxoglutarate metabolic process (GO:0006103)2.80063447
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79925488
117low-density lipoprotein particle clearance (GO:0034383)2.77673121
118negative regulation of innate immune response (GO:0045824)2.77545140
119maternal placenta development (GO:0001893)2.77091224
120regulation of ARF GTPase activity (GO:0032312)2.75635111
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74076849
122regulation of tolerance induction (GO:0002643)2.71814281
123oxaloacetate metabolic process (GO:0006107)2.71095789
124regulation of macrophage cytokine production (GO:0010935)2.70865446
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70484369
126regulation of T-helper 2 cell differentiation (GO:0045628)2.69980877
127negative thymic T cell selection (GO:0045060)2.69301740
128negative regulation of type 2 immune response (GO:0002829)2.69183958
129regulation of T cell tolerance induction (GO:0002664)2.67544467
130tolerance induction (GO:0002507)2.67424464
131T cell selection (GO:0045058)2.67196871
132negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66443389
133negative regulation of T-helper cell differentiation (GO:0045623)2.66443389
134megakaryocyte development (GO:0035855)2.66208518
135positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.64165348
136negative regulation of interleukin-8 production (GO:0032717)2.63947787
137thymic T cell selection (GO:0045061)2.63693876
138regulation of tight junction assembly (GO:2000810)2.62477698
139production of molecular mediator involved in inflammatory response (GO:0002532)2.62447410
140lysine metabolic process (GO:0006553)2.61765252
141lysine catabolic process (GO:0006554)2.61765252
142positive T cell selection (GO:0043368)2.61640989
143negative regulation of potassium ion transmembrane transport (GO:1901380)2.61363772
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60157265
145negative regulation of cytokine production involved in immune response (GO:0002719)2.59854978
146cell communication by electrical coupling (GO:0010644)2.59758771
147negative regulation of vascular permeability (GO:0043116)2.58818325
148positive regulation of regulated secretory pathway (GO:1903307)2.58533476
149cell-substrate junction assembly (GO:0007044)2.58064178
150positive regulation of granulocyte differentiation (GO:0030854)2.57759278
151apoptotic cell clearance (GO:0043277)2.57729289
152T cell homeostasis (GO:0043029)2.57613345
153synaptic vesicle docking involved in exocytosis (GO:0016081)2.55880484
154epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55256715
155negative regulation of focal adhesion assembly (GO:0051895)2.53259177
156negative regulation of cell junction assembly (GO:1901889)2.53259177
157negative regulation of adherens junction organization (GO:1903392)2.53259177
158glucocorticoid receptor signaling pathway (GO:0042921)2.51210144
159regulation of synapse structural plasticity (GO:0051823)2.51184288
160mitotic G1/S transition checkpoint (GO:0044819)2.50511522
161proline transport (GO:0015824)2.48518100
162heterochromatin organization (GO:0070828)2.48086857
163regulation of Rap GTPase activity (GO:0032317)2.47873938
164sexual reproduction (GO:0019953)2.46410418
165regulation of NFAT protein import into nucleus (GO:0051532)2.46283271
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.45123809
167peptidyl-arginine omega-N-methylation (GO:0035247)2.44974904
168tricarboxylic acid metabolic process (GO:0072350)2.41497324
169positive regulation of fibroblast migration (GO:0010763)2.41207045
170cerebellar Purkinje cell layer development (GO:0021680)2.39327325
171heart trabecula formation (GO:0060347)2.38818828
172patterning of blood vessels (GO:0001569)2.38385248
173positive regulation of fatty acid beta-oxidation (GO:0032000)2.34938619
174positive regulation of lamellipodium assembly (GO:0010592)2.34885567
175fatty acid transmembrane transport (GO:1902001)2.31910244
176regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31269401
177tricarboxylic acid cycle (GO:0006099)2.31248067
178positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.30604142
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30545263
180signal complex assembly (GO:0007172)2.29762088
181protein localization to kinetochore (GO:0034501)2.29085800
182G1 DNA damage checkpoint (GO:0044783)2.27521902
183alanine transport (GO:0032328)2.26901396
184negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.26722078
185apoptotic process involved in morphogenesis (GO:0060561)2.24898895
186positive regulation of nitric-oxide synthase activity (GO:0051000)2.24449216
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24326172
188establishment of apical/basal cell polarity (GO:0035089)2.24210844
189fatty acid homeostasis (GO:0055089)2.23452737
190cellular response to osmotic stress (GO:0071470)2.22827885
191spliceosomal tri-snRNP complex assembly (GO:0000244)2.22467641
192cortical actin cytoskeleton organization (GO:0030866)2.22114584
193renal filtration (GO:0097205)2.21801576
194aspartate family amino acid catabolic process (GO:0009068)2.21470607
1954-hydroxyproline metabolic process (GO:0019471)2.20876760
196neuromuscular process controlling balance (GO:0050885)2.20023663
197negative regulation of cardiac muscle tissue growth (GO:0055022)2.19844034
198negative regulation of heart growth (GO:0061117)2.19844034
199regulation of short-term neuronal synaptic plasticity (GO:0048172)2.19816453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.31515073
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.85486384
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.78326474
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.63639131
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25853418
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.21164078
7E2F7_22180533_ChIP-Seq_HELA_Human2.95887614
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.92016154
9MYC_22102868_ChIP-Seq_BL_Human2.91127660
10VDR_24763502_ChIP-Seq_THP-1_Human2.76818896
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.57975035
12ZNF263_19887448_ChIP-Seq_K562_Human2.57897381
13CLOCK_20551151_ChIP-Seq_293T_Human2.55236254
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54967993
15SCL_19346495_ChIP-Seq_HPC-7_Human2.54953322
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54477785
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.50092589
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.47606928
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.42795810
20* ELK3_25401928_ChIP-Seq_HUVEC_Human2.39694912
21KDM2B_26808549_Chip-Seq_DND41_Human2.38430205
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37843089
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.36381379
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31984883
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.28021844
26SPI1_23547873_ChIP-Seq_NB4_Human2.27548583
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.21353152
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21064510
29LXR_22292898_ChIP-Seq_THP-1_Human2.16734884
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11379838
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05242627
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04563071
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04343926
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01901320
35RUNX_20019798_ChIP-Seq_JUKART_Human1.96545501
36* TCF7_22412390_ChIP-Seq_EML_Mouse1.94781754
37* VDR_21846776_ChIP-Seq_THP-1_Human1.94475709
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.92812703
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91851016
40MAF_26560356_Chip-Seq_TH2_Human1.88081370
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87942207
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87857256
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.80584872
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78818180
45* KDM2B_26808549_Chip-Seq_K562_Human1.76730843
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75265603
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.73331437
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72691060
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70522924
50* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69160696
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.68994372
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68966794
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.68839845
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68052598
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.67879695
56MYB_26560356_Chip-Seq_TH2_Human1.67224399
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67085853
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66987496
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66820343
60MYB_26560356_Chip-Seq_TH1_Human1.66599033
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.66510601
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65866002
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63479342
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62616720
65RACK7_27058665_Chip-Seq_MCF-7_Human1.61094245
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56696502
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56351351
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55804960
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55145226
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52388152
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.49231225
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47734190
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46615836
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45522526
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42539326
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42346962
77TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.39582844
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39391029
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39238459
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.38697168
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37010171
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36247156
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35537033
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34442946
85ATF3_27146783_Chip-Seq_COLON_Human1.32816397
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32008853
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31652919
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30542046
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30195278
90* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28882495
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28850494
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28559587
93VDR_24787735_ChIP-Seq_THP-1_Human1.28452265
94TP53_22127205_ChIP-Seq_IMR90_Human1.26592081
95BCL6_27268052_Chip-Seq_Bcells_Human1.25644936
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24456649
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24213385
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24136171
99UTX_26944678_Chip-Seq_JUKART_Human1.24003253
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23575585
101CREB1_26743006_Chip-Seq_LNCaP_Human1.23540476
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23451832
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23262288
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22746425
105P68_20966046_ChIP-Seq_HELA_Human1.22443700
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22220423
107* MAF_26560356_Chip-Seq_TH1_Human1.22193168
108TBX20_22080862_ChIP-Seq_HEART_Mouse1.21662890
109TBX20_22328084_ChIP-Seq_HEART_Mouse1.21662890
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21067900
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.20891867
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.20453956
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19881728
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19875683
115BCOR_27268052_Chip-Seq_Bcells_Human1.19284871
116GATA2_19941826_ChIP-Seq_K562_Human1.18840583
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18069852
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17429342
119* SPI1_23127762_ChIP-Seq_K562_Human1.16709063
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16669789
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14979208
122GATA3_27048872_Chip-Seq_THYMUS_Human1.14286810
123ELF1_20517297_ChIP-Seq_JURKAT_Human1.14126259
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12963716
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12436191
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10875947
127* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10423368
128HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10330235
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09132913
130BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09107328
131ERG_21242973_ChIP-ChIP_JURKAT_Human1.08999161
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08463631
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07983612
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07883745
135GATA1_19941826_ChIP-Seq_K562_Human1.07875099
136* NCOR1_26117541_ChIP-Seq_K562_Human1.07783001
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07341213
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07293874
139RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07084026
140* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05657312
141UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05104521
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04790055
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03960579
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03742519
145SMC4_20622854_ChIP-Seq_HELA_Human1.02646093
146PU_27001747_Chip-Seq_BMDM_Mouse1.02417007
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01402769
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01173988
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01117422
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99392126
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99325787
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99152463
153DROSHA_22980978_ChIP-Seq_HELA_Human0.98470362
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.98212123
155ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96423373
156TRIM28_21343339_ChIP-Seq_HEK293_Human0.95747032
157MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93514616
158GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93281131
159NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89859043
160* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88030324
161CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87630365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.63861332
2MP0003724_increased_susceptibility_to4.33211804
3MP0003436_decreased_susceptibility_to4.15161568
4MP0010368_abnormal_lymphatic_system3.17305119
5MP0001835_abnormal_antigen_presentation2.98325506
6MP0002419_abnormal_innate_immunity2.92273884
7MP0004859_abnormal_synaptic_plasticity2.92134488
8MP0005167_abnormal_blood-brain_barrier2.81253702
9MP0004272_abnormal_basement_membrane2.69340858
10MP0005623_abnormal_meninges_morphology2.69116479
11MP0004084_abnormal_cardiac_muscle2.55975544
12MP0005025_abnormal_response_to2.47663082
13MP0005464_abnormal_platelet_physiology2.44574250
14MP0000685_abnormal_immune_system2.28846667
15MP0005000_abnormal_immune_tolerance2.28674323
16MP0010352_gastrointestinal_tract_polyps2.27769728
17MP0002396_abnormal_hematopoietic_system2.21867882
18MP0002420_abnormal_adaptive_immunity2.20107849
19MP0001800_abnormal_humoral_immune2.19550749
20MP0001819_abnormal_immune_cell2.17902800
21MP0001790_abnormal_immune_system2.14395428
22MP0005387_immune_system_phenotype2.14395428
23MP0003566_abnormal_cell_adhesion2.13623418
24MP0002723_abnormal_immune_serum2.12914181
25MP0004130_abnormal_muscle_cell2.11361291
26MP0001533_abnormal_skeleton_physiology2.06528537
27MP0008438_abnormal_cutaneous_collagen2.06165545
28MP0002452_abnormal_antigen_presenting2.05156647
29MP0008260_abnormal_autophagy2.05029450
30MP0000465_gastrointestinal_hemorrhage2.04377521
31MP0003303_peritoneal_inflammation2.01989915
32MP0000751_myopathy1.97824394
33MP0009785_altered_susceptibility_to1.94811808
34MP0006082_CNS_inflammation1.93540053
35MP0003300_gastrointestinal_ulcer1.92833834
36MP0010234_abnormal_vibrissa_follicle1.86268724
37MP0003763_abnormal_thymus_physiology1.83729665
38MP0005451_abnormal_body_composition1.82003115
39MP0005058_abnormal_lysosome_morphology1.80804814
40MP0005671_abnormal_response_to1.80562317
41MP0002398_abnormal_bone_marrow1.79989584
42MP0002405_respiratory_system_inflammati1.78463876
43MP0008961_abnormal_basal_metabolism1.69957972
44MP0002148_abnormal_hypersensitivity_rea1.68545176
45MP0003279_aneurysm1.68083250
46MP0000716_abnormal_immune_system1.65959033
47MP0001879_abnormal_lymphatic_vessel1.62928264
48MP0002132_abnormal_respiratory_system1.60986538
49MP0004087_abnormal_muscle_fiber1.60401470
50MP0004947_skin_inflammation1.58276465
51MP0000747_muscle_weakness1.57287241
52MP0004858_abnormal_nervous_system1.56698053
53MP0005330_cardiomyopathy1.55661802
54MP0003091_abnormal_cell_migration1.53625336
55MP0003172_abnormal_lysosome_physiology1.53463236
56MP0010630_abnormal_cardiac_muscle1.52305462
57MP0002722_abnormal_immune_system1.51553342
58MP0010307_abnormal_tumor_latency1.51178777
59MP0009780_abnormal_chondrocyte_physiolo1.50640347
60MP0002269_muscular_atrophy1.49295514
61MP0004185_abnormal_adipocyte_glucose1.49201772
62MP0005076_abnormal_cell_differentiation1.48586024
63MP0006138_congestive_heart_failure1.45916401
64MP0000013_abnormal_adipose_tissue1.45399416
65MP0004233_abnormal_muscle_weight1.44362378
66MP0002429_abnormal_blood_cell1.43655562
67MP0000703_abnormal_thymus_morphology1.43042697
68MP0010155_abnormal_intestine_physiology1.42273764
69MP0000689_abnormal_spleen_morphology1.41256865
70MP0009333_abnormal_splenocyte_physiolog1.40417928
71MP0004036_abnormal_muscle_relaxation1.40352975
72MP0009840_abnormal_foam_cell1.37946659
73MP0000858_altered_metastatic_potential1.34506417
74MP0001845_abnormal_inflammatory_respons1.33536796
75MP0001730_embryonic_growth_arrest1.33219285
76MP0002998_abnormal_bone_remodeling1.30752160
77MP0001958_emphysema1.30399948
78MP0006054_spinal_hemorrhage1.30122689
79MP0004381_abnormal_hair_follicle1.29495551
80MP0009278_abnormal_bone_marrow1.28939329
81MP0005023_abnormal_wound_healing1.28534372
82MP0003075_altered_response_to1.27799140
83MP0001915_intracranial_hemorrhage1.26843934
84MP0003191_abnormal_cellular_cholesterol1.24838233
85MP0010329_abnormal_lipoprotein_level1.24680061
86MP0001544_abnormal_cardiovascular_syste1.23855117
87MP0005385_cardiovascular_system_phenoty1.23855117
88MP0003123_paternal_imprinting1.23346590
89MP0005360_urolithiasis1.23057092
90MP0009764_decreased_sensitivity_to1.21567515
91MP0002086_abnormal_extraembryonic_tissu1.20307850
92MP0000733_abnormal_muscle_development1.20243271
93MP0004883_abnormal_blood_vessel1.19836629
94MP0003329_amyloid_beta_deposits1.18629085
95MP0008469_abnormal_protein_level1.18497773
96MP0003984_embryonic_growth_retardation1.17490613
97MP0002088_abnormal_embryonic_growth/wei1.15795804
98MP0001851_eye_inflammation1.15575344
99MP0002925_abnormal_cardiovascular_devel1.15432059
100MP0003122_maternal_imprinting1.14996038
101MP0000003_abnormal_adipose_tissue1.13039280
102MP0000750_abnormal_muscle_regeneration1.12207043
103MP0008874_decreased_physiological_sensi1.10838245
104MP0002933_joint_inflammation1.10625544
105MP0003635_abnormal_synaptic_transmissio1.10104664
106MP0003866_abnormal_defecation1.10003420
107MP0001849_ear_inflammation1.09969688
108MP0004510_myositis1.09891075
109MP0004808_abnormal_hematopoietic_stem1.09810648
110MP0002128_abnormal_blood_circulation1.08377713
111MP0004215_abnormal_myocardial_fiber1.06862669
112MP0002822_catalepsy1.06236988
113MP0005666_abnormal_adipose_tissue1.06228018
114MP0005390_skeleton_phenotype1.05723801
115MP0005375_adipose_tissue_phenotype1.04060388
116MP0005085_abnormal_gallbladder_physiolo1.04046867
117MP0001672_abnormal_embryogenesis/_devel1.03558614
118MP0005380_embryogenesis_phenotype1.03558614
119MP0002837_dystrophic_cardiac_calcinosis1.02755959
120MP0004197_abnormal_fetal_growth/weight/1.02602974
121MP0008775_abnormal_heart_ventricle1.02386074
122MP0003221_abnormal_cardiomyocyte_apopto1.01055537
123MP0003283_abnormal_digestive_organ0.99885311
124MP0003633_abnormal_nervous_system0.99412972
125MP0000015_abnormal_ear_pigmentation0.99136063
126MP0000266_abnormal_heart_morphology0.99050698
127MP0003045_fibrosis0.98494422
128MP0005409_darkened_coat_color0.97675422
129MP0000343_altered_response_to0.97520147
130MP0005164_abnormal_response_to0.97397333
131MP0004085_abnormal_heartbeat0.96056150
132MP0002089_abnormal_postnatal_growth/wei0.95349288
133MP0008770_decreased_survivor_rate0.95085129
134MP0002877_abnormal_melanocyte_morpholog0.93259811
135MP0005397_hematopoietic_system_phenotyp0.92505345
136MP0001545_abnormal_hematopoietic_system0.92505345
137MP0002166_altered_tumor_susceptibility0.90822727
138MP0003828_pulmonary_edema0.90677958
139MP0001614_abnormal_blood_vessel0.90516794
140MP0000767_abnormal_smooth_muscle0.90013400
141MP0000759_abnormal_skeletal_muscle0.89802929
142MP0000249_abnormal_blood_vessel0.89451366
143MP0002332_abnormal_exercise_endurance0.88942640
144MP0004811_abnormal_neuron_physiology0.88698437
145MP0001873_stomach_inflammation0.87640567
146MP0003690_abnormal_glial_cell0.85455603
147MP0002909_abnormal_adrenal_gland0.84904823
148MP0003448_altered_tumor_morphology0.84620131
149MP0000604_amyloidosis0.84137261
150MP0002084_abnormal_developmental_patter0.83397491
151MP0002972_abnormal_cardiac_muscle0.82918344
152* MP0002080_prenatal_lethality0.81182631
153MP0001697_abnormal_embryo_size0.80154824
154MP0002138_abnormal_hepatobiliary_system0.78198116
155MP0003806_abnormal_nucleotide_metabolis0.78073244
156MP0005166_decreased_susceptibility_to0.77576087
157MP0002063_abnormal_learning/memory/cond0.77454077
158MP0003631_nervous_system_phenotype0.76215257
159MP0002139_abnormal_hepatobiliary_system0.75671340
160MP0001663_abnormal_digestive_system0.74873890
161MP0001853_heart_inflammation0.74728494
162MP0005310_abnormal_salivary_gland0.74516790
163MP0003795_abnormal_bone_structure0.74128807
164MP0003656_abnormal_erythrocyte_physiolo0.73655746
165MP0001986_abnormal_taste_sensitivity0.69125018
166MP0009763_increased_sensitivity_to0.62372845
167MP0003183_abnormal_peptide_metabolism0.62202694
168MP0005075_abnormal_melanosome_morpholog0.61428816
169MP0000678_abnormal_parathyroid_gland0.60438316

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.33484176
2Recurrent abscess formation (HP:0002722)4.83900283
3Myositis (HP:0100614)4.76135201
4Recurrent bacterial skin infections (HP:0005406)4.57516342
5Abnormality of macrophages (HP:0004311)4.45581310
6Cerebral aneurysm (HP:0004944)4.31633008
7Orchitis (HP:0100796)4.22531587
8Elevated erythrocyte sedimentation rate (HP:0003565)4.08546135
9Obstructive lung disease (HP:0006536)3.96032799
10Chronic obstructive pulmonary disease (HP:0006510)3.96032799
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.73658513
12Optic neuritis (HP:0100653)3.72558528
13Retrobulbar optic neuritis (HP:0100654)3.72558528
14Stomatitis (HP:0010280)3.70494950
15Recurrent fungal infections (HP:0002841)3.62219351
16Recurrent gram-negative bacterial infections (HP:0005420)3.60203013
17Prolonged bleeding time (HP:0003010)3.58186505
18Abnormality of the lower motor neuron (HP:0002366)3.55800233
19Gastrointestinal infarctions (HP:0005244)3.43577790
20Increased IgE level (HP:0003212)3.38528944
21Cellulitis (HP:0100658)3.23099844
22Hyperacusis (HP:0010780)3.19552262
23Recurrent skin infections (HP:0001581)3.19026001
24Recurrent cutaneous fungal infections (HP:0011370)3.18930495
25Chronic mucocutaneous candidiasis (HP:0002728)3.18930495
26Protrusio acetabuli (HP:0003179)3.16516411
27Mediastinal lymphadenopathy (HP:0100721)3.12579564
28Meningitis (HP:0001287)3.10950771
29Deep venous thrombosis (HP:0002625)3.08541150
30Gingivitis (HP:0000230)2.94826394
31Chest pain (HP:0100749)2.90831956
32Lymphangioma (HP:0100764)2.86376320
33Epistaxis (HP:0000421)2.86364540
34Encephalitis (HP:0002383)2.82142844
35Episodic fever (HP:0001954)2.80646828
36Keratoconjunctivitis sicca (HP:0001097)2.78081909
37Urticaria (HP:0001025)2.76534336
38Resting tremor (HP:0002322)2.76297499
39Distal upper limb amyotrophy (HP:0007149)2.76119293
40Upper limb amyotrophy (HP:0009129)2.76119293
41Difficulty running (HP:0009046)2.74184297
42Annular pancreas (HP:0001734)2.71503375
43Hypochromic anemia (HP:0001931)2.71313442
44Polycythemia (HP:0001901)2.66758079
45Hemoptysis (HP:0002105)2.66446746
46Increased connective tissue (HP:0009025)2.64213308
47Aneurysm (HP:0002617)2.60056285
48Spastic diplegia (HP:0001264)2.58381022
49Arterial thrombosis (HP:0004420)2.57411515
50Achilles tendon contracture (HP:0001771)2.56199065
51Keratoconjunctivitis (HP:0001096)2.54564293
52Abnormality of the Achilles tendon (HP:0005109)2.54032987
53Gastrointestinal inflammation (HP:0004386)2.52893187
54Hypochromic microcytic anemia (HP:0004840)2.51836454
55Inflammation of the large intestine (HP:0002037)2.49387003
56Petechiae (HP:0000967)2.46746763
57Increased cerebral lipofuscin (HP:0011813)2.46484959
58Amyloidosis (HP:0011034)2.46466589
59Vasculitis (HP:0002633)2.45608483
60Pointed chin (HP:0000307)2.44307308
61Recurrent viral infections (HP:0004429)2.44257995
62Granulocytopenia (HP:0001913)2.43317236
63Shallow orbits (HP:0000586)2.42643931
64Hypertensive crisis (HP:0100735)2.40856487
65Hemiplegia (HP:0002301)2.39018941
66Insomnia (HP:0100785)2.36518072
67Hyporeflexia of lower limbs (HP:0002600)2.35813522
68Broad metatarsal (HP:0001783)2.33225536
69Pustule (HP:0200039)2.33174604
70Bowel diverticulosis (HP:0005222)2.33149599
71Panhypogammaglobulinemia (HP:0003139)2.32988775
72Difficulty climbing stairs (HP:0003551)2.30489879
73Colitis (HP:0002583)2.29591952
74Ependymoma (HP:0002888)2.29344876
75Hand muscle atrophy (HP:0009130)2.29259424
76Pulmonary embolism (HP:0002204)2.27411334
77Elfin facies (HP:0004428)2.27013228
78Pulmonary infiltrates (HP:0002113)2.25871755
79Dysmetric saccades (HP:0000641)2.22850157
80Hematochezia (HP:0002573)2.22716862
81Abnormality of the astrocytes (HP:0100707)2.22657426
82Astrocytoma (HP:0009592)2.22657426
83Exercise-induced muscle cramps (HP:0003710)2.22643524
84Leukocytosis (HP:0001974)2.21821357
85Abnormal platelet volume (HP:0011876)2.21308168
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20542763
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.20142735
88Mitral valve prolapse (HP:0001634)2.19600467
89Osteomyelitis (HP:0002754)2.17015371
90Dilatation of the ascending aorta (HP:0005111)2.16680148
91Gingival bleeding (HP:0000225)2.15169065
92Abnormality of T cell physiology (HP:0011840)2.13882893
93Bladder diverticulum (HP:0000015)2.13392893
94Myokymia (HP:0002411)2.12079560
95Microcytic anemia (HP:0001935)2.10681697
96Termporal pattern (HP:0011008)2.10188485
97Insidious onset (HP:0003587)2.10188485
98Fibroma (HP:0010614)2.09541625
99Disproportionate tall stature (HP:0001519)2.08699237
100Striae distensae (HP:0001065)2.08290394
101Viral hepatitis (HP:0006562)2.08225525
102Urinary urgency (HP:0000012)2.06960648
103Enlarged penis (HP:0000040)2.06952107
104Ulnar bowing (HP:0003031)2.06919272
105Abnormal platelet function (HP:0011869)2.06368796
106Impaired platelet aggregation (HP:0003540)2.06368796
107Ankle contracture (HP:0006466)2.04989516
108Renovascular hypertension (HP:0100817)2.03345089
109Papilledema (HP:0001085)2.02727195
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02268794
111Renal duplication (HP:0000075)2.01415467
112Fibrous tissue neoplasm (HP:0012316)2.00607746
113Dysostosis multiplex (HP:0000943)1.98784811
114High pitched voice (HP:0001620)1.98599189
115Segmental peripheral demyelination/remyelination (HP:0003481)1.98541293
116Pseudobulbar signs (HP:0002200)1.98425611
117Macroorchidism (HP:0000053)1.98355200
118Increased variability in muscle fiber diameter (HP:0003557)1.98311269
119Acne (HP:0001061)1.97134782
120Abnormality of T cells (HP:0002843)1.96077566
121Spontaneous hematomas (HP:0007420)1.95844118
122Angiofibromas (HP:0010615)1.95291023
123Adenoma sebaceum (HP:0009720)1.95291023
124Aortic aneurysm (HP:0004942)1.95243439
125Fatigue (HP:0012378)1.93905892
126Increased serum ferritin (HP:0003281)1.93732193
127Wrist flexion contracture (HP:0001239)1.93437584
128Abnormality of the fingertips (HP:0001211)1.93430890
129Metaphyseal cupping (HP:0003021)1.93385880
130Visceral angiomatosis (HP:0100761)1.93144738
131Anorexia (HP:0002039)1.89067381
132Rapidly progressive (HP:0003678)1.86601745
133Short 4th metacarpal (HP:0010044)1.86562819
134Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86562819
135Hemangiomatosis (HP:0007461)1.86132009
136Hepatosplenomegaly (HP:0001433)1.86014060
137Overriding aorta (HP:0002623)1.86005181
138Genu recurvatum (HP:0002816)1.85217016
139Interstitial pulmonary disease (HP:0006530)1.84726804
140Long toe (HP:0010511)1.84713781
141Sepsis (HP:0100806)1.83785709
142Abnormality of the 4th metacarpal (HP:0010012)1.81614700
143Easy fatigability (HP:0003388)1.81243775
144Neoplasm of the heart (HP:0100544)1.80003917
145Slow saccadic eye movements (HP:0000514)1.79506999
146Hemorrhage of the eye (HP:0011885)1.78949934
147Abnormality of the endocardium (HP:0004306)1.78737790
148Abnormality of skeletal muscle fiber size (HP:0012084)1.78399695
149Lower limb amyotrophy (HP:0007210)1.78222946
150Abnormality of the pleura (HP:0002103)1.78169751
151Peritonitis (HP:0002586)1.77896131
152Atrioventricular block (HP:0001678)1.77055481
153Nonimmune hydrops fetalis (HP:0001790)1.76914782
154Abnormality of oral frenula (HP:0000190)1.75838063
155Premature rupture of membranes (HP:0001788)1.75529383
156Sudden death (HP:0001699)1.75264694
157Bruising susceptibility (HP:0000978)1.74187149
158Ankyloglossia (HP:0010296)1.73835148
159Abnormality of iron homeostasis (HP:0011031)1.73088215
160Thrombocytosis (HP:0001894)1.72910604
161Frequent falls (HP:0002359)1.72739117
162Radial bowing (HP:0002986)1.72701165
163Glomerulopathy (HP:0100820)1.72479926
164Abnormality of pain sensation (HP:0010832)1.72372081
165Impaired pain sensation (HP:0007328)1.72372081
166Polygenic inheritance (HP:0010982)1.71987072
167Increased density of long bones (HP:0006392)1.71743402
168Esophageal varix (HP:0002040)1.71498850
169Hypergammaglobulinemia (HP:0010702)1.71456919
170Subacute progressive viral hepatitis (HP:0006572)1.71118097
171Skin ulcer (HP:0200042)1.70907592
172Purpura (HP:0000979)1.70238617
173Myoglobinuria (HP:0002913)1.67977737
174Limb-girdle muscle atrophy (HP:0003797)1.67735313
175Cutaneous melanoma (HP:0012056)1.67568202
176Scapular winging (HP:0003691)1.66731355
177Cortical dysplasia (HP:0002539)1.64871115
178Multiple enchondromatosis (HP:0005701)1.64442269
179Hypopigmentation of the fundus (HP:0007894)1.63553578
180Flat cornea (HP:0007720)1.63385996
181Cerebral inclusion bodies (HP:0100314)1.61869172
182Bundle branch block (HP:0011710)1.60576188
183Hamartoma of the eye (HP:0010568)1.60315114
184Abnormality of the peritoneum (HP:0002585)1.60201143
185Hallux valgus (HP:0001822)1.60088920
186Buphthalmos (HP:0000557)1.59443451
187Hypercortisolism (HP:0001578)1.59132491
188Turricephaly (HP:0000262)1.58998424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.41683632
2TRIB34.39753027
3RIPK44.11548286
4TIE13.38770870
5EEF2K3.17474549
6MAP4K12.97797625
7BLK2.59389182
8PRPF4B2.52355716
9IRAK42.45171230
10SCYL22.44166239
11TTN2.32815775
12RIPK12.31348177
13CSK2.26113023
14TYK22.22766218
15NEK12.17706806
16PDGFRA2.12955733
17MAP3K91.99827677
18TNK21.97451538
19KDR1.93130133
20KSR21.86663567
21PRKD31.73900185
22BTK1.71986847
23ERN11.69988791
24JAK31.68651779
25LRRK21.61098560
26MAP3K31.59189652
27MAP3K101.58110391
28TYRO31.56944436
29ALK1.51125908
30BMX1.44775302
31PAK61.43882967
32PTK61.42125950
33SMG11.42047440
34MAP3K11.39253355
35CAMKK11.37234757
36RET1.35547727
37TGFBR21.35065367
38TGFBR11.33216857
39NTRK11.32806838
40SYK1.29758796
41MAP3K141.28925289
42CDK121.28043795
43MAP3K61.27964074
44PAK41.27828830
45PRKD21.25094699
46IRAK31.23972727
47LATS21.23451646
48KIT1.22853581
49ICK1.14684885
50TBK11.13303840
51IRAK11.07704695
52DDR21.05731005
53TEC1.04505073
54PAK21.02281300
55LYN1.00062249
56IRAK20.97801298
57MINK10.97493590
58FGFR40.97447087
59LCK0.96189711
60MTOR0.95645822
61PRKCH0.94332014
62FGR0.93907226
63ITK0.92774787
64FGFR20.92212089
65NTRK30.91684131
66PTK2B0.90849128
67LMTK20.89487010
68CAMK1G0.87825047
69FLT30.87580465
70MAP2K40.86605578
71STK100.86523041
72MAP2K30.85269932
73DAPK20.84803651
74CAMK1D0.81399805
75CSF1R0.81147486
76GRK60.81114344
77SIK10.80975894
78JAK10.80601187
79SIK30.80301637
80TXK0.79969401
81PDK40.78776652
82PDK30.78776652
83MAP3K70.78476959
84PDGFRB0.78196957
85SIK20.77823940
86TAOK10.76687597
87MARK30.76524358
88PIK3CG0.76519006
89YES10.76159651
90MAP3K20.75854845
91TESK20.75737232
92IKBKE0.74475835
93TAOK20.73059067
94MAP3K80.72141243
95FGFR10.70565191
96CDC42BPA0.70437026
97HIPK20.69213197
98STK380.68381279
99PAK30.68236776
100PRKG20.67457124
101DAPK10.65101333
102MAP3K110.65038424
103TSSK60.63490132
104PTK20.62511210
105RPS6KB20.62126285
106MOS0.62064532
107BMPR20.61622989
108CDK60.61248414
109PDK10.59986057
110MATK0.59453367
111PRKD10.59422181
112RPS6KL10.59035843
113RPS6KC10.59035843
114EPHB10.58402291
115DMPK0.57963388
116FER0.57534089
117MAPK70.56760663
118ILK0.56533673
119FES0.56201836
120FGFR30.54768146
121CDC70.53225109
122MAP3K40.52738577
123TAOK30.52666809
124PDPK10.51704977
125NTRK20.51662313
126RPS6KA60.51267269
127CDK150.50996885
128EPHA40.50711047
129TRPM70.50587807
130IKBKB0.50261723
131JAK20.49727329
132DAPK30.48429684
133CLK10.47357771
134KSR10.47247675
135FYN0.46384355
136NEK20.46346365
137AKT20.46294810
138CDK140.45511189
139CDK180.43494145
140CDK40.42704977
141SGK30.41166315
142HCK0.40219835
143CDK50.40210902
144SRC0.39591548
145RPS6KA20.39529431
146RAF10.39357379
147CDK11A0.39272583
148ZAP700.38968187
149MAP3K130.38138573
150MAPK120.37594431
151MAP2K10.37344656
152STK110.36692792
153MARK20.36412517

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.90428843
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43852184
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.89596456
4Osteoclast differentiation_Homo sapiens_hsa043802.59779249
5Leishmaniasis_Homo sapiens_hsa051402.56650370
6Acute myeloid leukemia_Homo sapiens_hsa052212.21943569
7Arginine biosynthesis_Homo sapiens_hsa002202.19503386
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16781272
9B cell receptor signaling pathway_Homo sapiens_hsa046622.14124968
10Other glycan degradation_Homo sapiens_hsa005112.03314997
11Staphylococcus aureus infection_Homo sapiens_hsa051501.89985206
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83489253
13Tuberculosis_Homo sapiens_hsa051521.79111659
14Biosynthesis of amino acids_Homo sapiens_hsa012301.76471500
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74335816
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67040784
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62467031
18Malaria_Homo sapiens_hsa051441.62221133
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59513951
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55263997
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54302885
22Toxoplasmosis_Homo sapiens_hsa051451.51616221
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51083476
24Carbon metabolism_Homo sapiens_hsa012001.49970745
25mTOR signaling pathway_Homo sapiens_hsa041501.49366715
26Graft-versus-host disease_Homo sapiens_hsa053321.49023874
27Chemokine signaling pathway_Homo sapiens_hsa040621.42096229
28Measles_Homo sapiens_hsa051621.42053322
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.41726279
30Allograft rejection_Homo sapiens_hsa053301.41468873
31Glioma_Homo sapiens_hsa052141.37902999
32T cell receptor signaling pathway_Homo sapiens_hsa046601.37064268
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.36504646
34Autoimmune thyroid disease_Homo sapiens_hsa053201.31303333
35Influenza A_Homo sapiens_hsa051641.30252700
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29830406
37Hematopoietic cell lineage_Homo sapiens_hsa046401.28737594
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26957983
39Hepatitis B_Homo sapiens_hsa051611.24069598
40Primary immunodeficiency_Homo sapiens_hsa053401.23502491
41Chronic myeloid leukemia_Homo sapiens_hsa052201.22868233
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22084468
43VEGF signaling pathway_Homo sapiens_hsa043701.21418862
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21399476
45Focal adhesion_Homo sapiens_hsa045101.21152792
46Bile secretion_Homo sapiens_hsa049761.20456738
47Notch signaling pathway_Homo sapiens_hsa043301.20219434
48TNF signaling pathway_Homo sapiens_hsa046681.19530932
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19071182
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.19057584
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18037107
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.17089587
53Dilated cardiomyopathy_Homo sapiens_hsa054141.16830341
54Proteoglycans in cancer_Homo sapiens_hsa052051.15944980
55Shigellosis_Homo sapiens_hsa051311.12881133
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.12696842
57Estrogen signaling pathway_Homo sapiens_hsa049151.10008692
58Non-small cell lung cancer_Homo sapiens_hsa052231.09875194
59African trypanosomiasis_Homo sapiens_hsa051431.09091008
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08239035
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.07825547
62Phagosome_Homo sapiens_hsa041451.07778775
63Fatty acid degradation_Homo sapiens_hsa000711.07773308
64Prolactin signaling pathway_Homo sapiens_hsa049171.03429387
65Legionellosis_Homo sapiens_hsa051341.03183248
66Herpes simplex infection_Homo sapiens_hsa051681.02072389
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00764303
68Fatty acid metabolism_Homo sapiens_hsa012120.98482635
69HIF-1 signaling pathway_Homo sapiens_hsa040660.98084482
70Gap junction_Homo sapiens_hsa045400.97367807
71Antigen processing and presentation_Homo sapiens_hsa046120.96683251
72Salmonella infection_Homo sapiens_hsa051320.94909450
73Insulin signaling pathway_Homo sapiens_hsa049100.94881378
74Fatty acid biosynthesis_Homo sapiens_hsa000610.93210210
75PPAR signaling pathway_Homo sapiens_hsa033200.92265799
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.91709735
77Apoptosis_Homo sapiens_hsa042100.91608577
78Pertussis_Homo sapiens_hsa051330.90979820
79Long-term potentiation_Homo sapiens_hsa047200.90564405
80Hepatitis C_Homo sapiens_hsa051600.89834274
81Type I diabetes mellitus_Homo sapiens_hsa049400.89563247
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89503517
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.89403861
84Insulin resistance_Homo sapiens_hsa049310.89202880
85Choline metabolism in cancer_Homo sapiens_hsa052310.87458818
86Dorso-ventral axis formation_Homo sapiens_hsa043200.85958443
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85034442
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83395064
89Amoebiasis_Homo sapiens_hsa051460.83012923
90Rap1 signaling pathway_Homo sapiens_hsa040150.82982668
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.82665370
92Oxytocin signaling pathway_Homo sapiens_hsa049210.82102027
93Glucagon signaling pathway_Homo sapiens_hsa049220.81391158
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81244243
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81119048
96AMPK signaling pathway_Homo sapiens_hsa041520.80997902
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80693379
98Lysine degradation_Homo sapiens_hsa003100.80664329
99Gastric acid secretion_Homo sapiens_hsa049710.80453575
100Pentose phosphate pathway_Homo sapiens_hsa000300.80410345
101Lysosome_Homo sapiens_hsa041420.79954466
102Synaptic vesicle cycle_Homo sapiens_hsa047210.78878143
103Platelet activation_Homo sapiens_hsa046110.78615130
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77991851
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.77648708
106Renin secretion_Homo sapiens_hsa049240.76678399
107Viral carcinogenesis_Homo sapiens_hsa052030.76322807
108Bladder cancer_Homo sapiens_hsa052190.75417348
109Viral myocarditis_Homo sapiens_hsa054160.75399492
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75344750
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75134875
112Adherens junction_Homo sapiens_hsa045200.74637794
113Renal cell carcinoma_Homo sapiens_hsa052110.74526168
114Inositol phosphate metabolism_Homo sapiens_hsa005620.74316912
115FoxO signaling pathway_Homo sapiens_hsa040680.73905010
116Small cell lung cancer_Homo sapiens_hsa052220.73312800
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70700421
118ECM-receptor interaction_Homo sapiens_hsa045120.70678102
119GnRH signaling pathway_Homo sapiens_hsa049120.70427198
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70078174
121Prion diseases_Homo sapiens_hsa050200.69867320
122One carbon pool by folate_Homo sapiens_hsa006700.69860207
123Endocytosis_Homo sapiens_hsa041440.69749106
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69210363
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68405327
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68287400
127Pyruvate metabolism_Homo sapiens_hsa006200.68224846
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.68096479
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68034542
130Endometrial cancer_Homo sapiens_hsa052130.67293881
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66283228
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65832866
133HTLV-I infection_Homo sapiens_hsa051660.65335414
134Type II diabetes mellitus_Homo sapiens_hsa049300.65223640
135Complement and coagulation cascades_Homo sapiens_hsa046100.65105793
136ErbB signaling pathway_Homo sapiens_hsa040120.64817791
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64660026
138Propanoate metabolism_Homo sapiens_hsa006400.64179285
139MAPK signaling pathway_Homo sapiens_hsa040100.63329527
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63246332
141Olfactory transduction_Homo sapiens_hsa047400.62958568
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62772764
143Oocyte meiosis_Homo sapiens_hsa041140.62049925
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.60981568
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60337433
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60127390
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59526909
148Rheumatoid arthritis_Homo sapiens_hsa053230.58838854
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58572188
150Thyroid cancer_Homo sapiens_hsa052160.57754113
151Butanoate metabolism_Homo sapiens_hsa006500.57658589
152Circadian entrainment_Homo sapiens_hsa047130.57215771
153Pancreatic cancer_Homo sapiens_hsa052120.57153155
154Tryptophan metabolism_Homo sapiens_hsa003800.56958526
155Colorectal cancer_Homo sapiens_hsa052100.56321229
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55953551
157GABAergic synapse_Homo sapiens_hsa047270.55612161
158Salivary secretion_Homo sapiens_hsa049700.55073172
159Asthma_Homo sapiens_hsa053100.54982068
160Cyanoamino acid metabolism_Homo sapiens_hsa004600.54894607
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54420587
162Selenocompound metabolism_Homo sapiens_hsa004500.54020140
163Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53536232

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