PPM1H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.72740921
2postsynaptic membrane organization (GO:0001941)5.15063337
3negative regulation of synaptic transmission, GABAergic (GO:0032229)5.07557806
4presynaptic membrane organization (GO:0097090)5.00682897
5vocalization behavior (GO:0071625)4.54395326
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.37565543
7neuron cell-cell adhesion (GO:0007158)4.26939894
8neuronal action potential propagation (GO:0019227)4.24381319
9neurotransmitter-gated ion channel clustering (GO:0072578)4.20592161
10negative regulation of dendrite morphogenesis (GO:0050774)4.10733517
11synaptic vesicle exocytosis (GO:0016079)4.01372144
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.01219306
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.90954415
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79217147
15protein localization to synapse (GO:0035418)3.71572041
16startle response (GO:0001964)3.67645932
17short-term memory (GO:0007614)3.63772142
18regulation of synaptic vesicle exocytosis (GO:2000300)3.62506564
19negative regulation of dendrite development (GO:2000171)3.58953383
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57674403
21lactate metabolic process (GO:0006089)3.55310762
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.46185433
23cellular potassium ion homeostasis (GO:0030007)3.36421382
24positive regulation of glycolytic process (GO:0045821)3.33481714
25transferrin transport (GO:0033572)3.31368481
26positive regulation of synapse assembly (GO:0051965)3.31342414
27phagosome maturation (GO:0090382)3.30978194
28gamma-aminobutyric acid signaling pathway (GO:0007214)3.30931277
29regulation of synaptic transmission, GABAergic (GO:0032228)3.26155570
30regulation of synaptic vesicle transport (GO:1902803)3.24903826
31regulation of glutamate receptor signaling pathway (GO:1900449)3.19687554
32negative regulation of hormone biosynthetic process (GO:0032353)3.18479140
33trivalent inorganic cation transport (GO:0072512)3.17525474
34ferric iron transport (GO:0015682)3.17525474
35glutamate secretion (GO:0014047)3.16957713
36synaptic vesicle maturation (GO:0016188)3.14136402
37positive regulation of amino acid transport (GO:0051957)3.12617407
38positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.11150782
39sodium ion export (GO:0071436)3.10988587
40L-alpha-amino acid transmembrane transport (GO:1902475)3.03352259
41neuron-neuron synaptic transmission (GO:0007270)3.00686724
42zinc ion transport (GO:0006829)2.96730458
43positive regulation of macroautophagy (GO:0016239)2.94804404
44positive regulation of protein autophosphorylation (GO:0031954)2.93917624
45synaptic transmission, glutamatergic (GO:0035249)2.90803811
46positive regulation of membrane potential (GO:0045838)2.88713735
47ionotropic glutamate receptor signaling pathway (GO:0035235)2.88544535
48neurotransmitter secretion (GO:0007269)2.87453889
49negative regulation of hormone metabolic process (GO:0032351)2.85476312
50endothelium development (GO:0003158)2.85200792
51long-term synaptic potentiation (GO:0060291)2.83926440
52regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82707925
53positive regulation of neurotransmitter secretion (GO:0001956)2.82146410
54cerebellar granule cell differentiation (GO:0021707)2.81274452
55developmental pigmentation (GO:0048066)2.80667665
56glucosamine-containing compound catabolic process (GO:1901072)2.79461192
57exocrine pancreas development (GO:0031017)2.78951257
58superoxide anion generation (GO:0042554)2.77551553
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75391997
60fatty acid homeostasis (GO:0055089)2.71725228
61glutamate receptor signaling pathway (GO:0007215)2.70765773
62inositol phosphate catabolic process (GO:0071545)2.70532270
63hyperosmotic salinity response (GO:0042538)2.68210353
64serotonin metabolic process (GO:0042428)2.67232156
65eosinophil chemotaxis (GO:0048245)2.66814462
66regulation of postsynaptic membrane potential (GO:0060078)2.65561897
67regulation of synapse assembly (GO:0051963)2.64568642
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64467328
69aggressive behavior (GO:0002118)2.64188262
70membrane assembly (GO:0071709)2.62877646
71biotin metabolic process (GO:0006768)2.60841470
72long term synaptic depression (GO:0060292)2.60467743
73potassium ion import (GO:0010107)2.57679215
74regulation of neurotransmitter levels (GO:0001505)2.56430352
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56110754
76regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54905905
77serotonin receptor signaling pathway (GO:0007210)2.53949454
78ketone body metabolic process (GO:1902224)2.52759441
79energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.52597995
80ATP hydrolysis coupled proton transport (GO:0015991)2.52597995
81gamma-aminobutyric acid transport (GO:0015812)2.52420997
82neurofilament cytoskeleton organization (GO:0060052)2.51956670
83cellular ketone body metabolic process (GO:0046950)2.50454705
84regulation of respiratory system process (GO:0044065)2.50435160
85cochlea development (GO:0090102)2.50240917
86positive regulation of neurotransmitter transport (GO:0051590)2.49830345
87mechanosensory behavior (GO:0007638)2.48442753
88neuromuscular process controlling posture (GO:0050884)2.47975671
89potassium ion homeostasis (GO:0055075)2.47429092
90regulation of neurotransmitter secretion (GO:0046928)2.47329966
91branched-chain amino acid catabolic process (GO:0009083)2.46589272
92chemosensory behavior (GO:0007635)2.45570226
93peptidyl-cysteine modification (GO:0018198)2.45050021
94positive regulation of response to nutrient levels (GO:0032109)2.44148304
95positive regulation of response to extracellular stimulus (GO:0032106)2.44148304
96behavioral response to pain (GO:0048266)2.43653718
97regulation of neuronal synaptic plasticity (GO:0048168)2.43347640
98regulation of voltage-gated calcium channel activity (GO:1901385)2.42977718
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.42279108
100female mating behavior (GO:0060180)2.41223707
101cAMP catabolic process (GO:0006198)2.40681365
102interferon-gamma production (GO:0032609)2.40604488
103long-term memory (GO:0007616)2.40042761
104negative regulation of mast cell activation (GO:0033004)2.39901918
105insulin secretion (GO:0030073)2.39050232
106learning (GO:0007612)2.38864320
107response to histamine (GO:0034776)2.38706978
108cell communication involved in cardiac conduction (GO:0086065)2.38345254
109regulation of calcium ion-dependent exocytosis (GO:0017158)2.38225904
110eosinophil migration (GO:0072677)2.37665356
111protein localization to cilium (GO:0061512)2.37247635
112positive regulation of nitric-oxide synthase activity (GO:0051000)2.36737587
113positive regulation of respiratory burst (GO:0060267)2.36583264
114proline transport (GO:0015824)2.35838980
115regulation of Rac protein signal transduction (GO:0035020)2.35222544
116negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.34045982
117negative regulation of cell killing (GO:0031342)2.34045982
118zinc ion transmembrane transport (GO:0071577)2.33439699
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33385900
120cerebellar Purkinje cell differentiation (GO:0021702)2.33215397
121L-phenylalanine metabolic process (GO:0006558)2.32398535
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.32398535
123neurotransmitter uptake (GO:0001504)2.31807311
124regulation of hexokinase activity (GO:1903299)2.31534083
125regulation of glucokinase activity (GO:0033131)2.31534083
126regulation of type B pancreatic cell apoptotic process (GO:2000674)2.29798173
127synapse assembly (GO:0007416)2.29555203
128neurotransmitter transport (GO:0006836)2.29287872
129L-phenylalanine catabolic process (GO:0006559)2.28741800
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28741800
131vesicle docking involved in exocytosis (GO:0006904)2.28654775
132synaptic vesicle endocytosis (GO:0048488)2.28545707
133regulation of synaptic plasticity (GO:0048167)2.28127371
134regulation of female receptivity (GO:0045924)2.26937295
135signal release (GO:0023061)2.26380847
136regulation of amino acid transport (GO:0051955)2.25978460
137positive regulation of synaptic transmission, GABAergic (GO:0032230)2.25284756
138urinary tract smooth muscle contraction (GO:0014848)2.24192084
139lysine metabolic process (GO:0006553)2.24078750
140lysine catabolic process (GO:0006554)2.24078750
141prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.22348442
142myelin maintenance (GO:0043217)2.22246202
143innervation (GO:0060384)2.22233534
144regulation of cell communication by electrical coupling (GO:0010649)2.22122049
145vesicle docking (GO:0048278)2.21906626
146positive regulation of protein homodimerization activity (GO:0090073)2.21861106
147membrane depolarization (GO:0051899)2.21122582
148positive regulation of cardiac muscle cell differentiation (GO:2000727)2.21121980
149positive regulation of cellular amide metabolic process (GO:0034250)2.20990385
150synaptic vesicle transport (GO:0048489)2.20916901
151establishment of synaptic vesicle localization (GO:0097480)2.20916901
152response to cocaine (GO:0042220)2.20223713
153nodal signaling pathway (GO:0038092)2.20079339
154cellular sodium ion homeostasis (GO:0006883)2.19945967
155cell communication by electrical coupling (GO:0010644)2.19709237
156anterior/posterior axis specification, embryo (GO:0008595)2.18299571
157positive regulation of glycogen biosynthetic process (GO:0045725)2.18069364
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.17761971
159transcytosis (GO:0045056)2.15404358
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15324319
161regulation of clathrin-mediated endocytosis (GO:2000369)2.14472564
162positive regulation of dendritic spine morphogenesis (GO:0061003)2.14227909
163regulation of sodium ion transmembrane transporter activity (GO:2000649)2.14117707
164negative regulation of cell fate commitment (GO:0010454)2.11892144
165regulation of dendritic spine morphogenesis (GO:0061001)2.10999846
166regulation of heart rate by cardiac conduction (GO:0086091)2.10284248
167regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.10071870
168cerebellar Purkinje cell layer development (GO:0021680)2.10052518
169apical protein localization (GO:0045176)2.09783658
170peptidyl-tyrosine autophosphorylation (GO:0038083)2.09045731
171regulation of insulin secretion (GO:0050796)2.08932257
172pteridine-containing compound biosynthetic process (GO:0042559)2.08796501
173L-amino acid import (GO:0043092)2.08221397
174intestinal epithelial cell development (GO:0060576)2.07955074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.69393286
2EZH2_22144423_ChIP-Seq_EOC_Human3.14578680
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10131915
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.92731437
5* TAF15_26573619_Chip-Seq_HEK293_Human2.72654244
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64860956
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.59001545
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56444086
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54701097
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46038506
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40458431
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.40405976
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25373762
14IGF1R_20145208_ChIP-Seq_DFB_Human2.22246787
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.21658972
16P300_19829295_ChIP-Seq_ESCs_Human2.15579914
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11775844
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.05343682
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04469695
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98566277
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93593476
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.93443530
23AR_21572438_ChIP-Seq_LNCaP_Human1.92555324
24* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90760727
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.89227998
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88308573
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86783839
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84194427
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82488866
30AR_21909140_ChIP-Seq_LNCAP_Human1.80134089
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.78252616
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77981484
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77516718
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76196325
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75109253
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.74476387
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73562252
38* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71443647
39* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71443647
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.70691959
41ER_23166858_ChIP-Seq_MCF-7_Human1.68996534
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66251648
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65114633
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64855737
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64308184
46* RARB_27405468_Chip-Seq_BRAIN_Mouse1.63593622
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62334742
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.62035988
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.62015297
50* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61278381
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60677858
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59704792
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58398165
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56119671
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54936576
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54688956
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.53957573
58* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52713585
59* RNF2_27304074_Chip-Seq_NSC_Mouse1.51900834
60* REST_21632747_ChIP-Seq_MESCs_Mouse1.51841086
61* AR_25329375_ChIP-Seq_VCAP_Human1.50701146
62P53_22387025_ChIP-Seq_ESCs_Mouse1.50640252
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.50622285
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49907866
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48978169
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.48785297
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47711928
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45543469
69AHR_22903824_ChIP-Seq_MCF-7_Human1.44152127
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.41628109
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40673890
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40218773
73* FOXA1_25552417_ChIP-Seq_VCAP_Human1.39129992
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.37534543
75DROSHA_22980978_ChIP-Seq_HELA_Human1.37251521
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.36194343
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36113363
78* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35581944
79P300_18555785_Chip-Seq_ESCs_Mouse1.34535389
80* RNF2_27304074_Chip-Seq_ESCs_Mouse1.34122067
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33127296
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.32870644
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32674432
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.32602056
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31652946
86* EZH2_27294783_Chip-Seq_ESCs_Mouse1.30988869
87* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30890881
88TP53_18474530_ChIP-ChIP_U2OS_Human1.30350834
89STAT3_23295773_ChIP-Seq_U87_Human1.30245573
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29565618
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29274983
92FUS_26573619_Chip-Seq_HEK293_Human1.28912566
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28795198
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28012705
95JUN_21703547_ChIP-Seq_K562_Human1.27774774
96* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26109420
97* TCF4_23295773_ChIP-Seq_U87_Human1.25754826
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.25242950
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25231529
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.24761866
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24397168
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.23800697
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22386862
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22051675
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21912841
106* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.21874355
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21423019
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.20958926
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20426180
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20061663
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.19333118
112* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18719867
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18382150
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18334621
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18136151
116* RUNX2_22187159_ChIP-Seq_PCA_Human1.17986738
117* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17757330
118* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17757330
119* FOXA2_19822575_ChIP-Seq_HepG2_Human1.17696916
120KDM2B_26808549_Chip-Seq_REH_Human1.17011900
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16814874
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.16198462
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15563228
124VDR_22108803_ChIP-Seq_LS180_Human1.14795038
125PU1_27457419_Chip-Seq_LIVER_Mouse1.13331545
126* GATA3_24758297_ChIP-Seq_MCF-7_Human1.12370061
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12077429
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11609287
129NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11579337
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11042846
131EWS_26573619_Chip-Seq_HEK293_Human1.10748215
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10542248
133ARNT_22903824_ChIP-Seq_MCF-7_Human1.09872536
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09760328
135* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08588958
136OCT4_18555785_Chip-Seq_ESCs_Mouse1.08108192
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07255726
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04261376
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02635544
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00435837
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98743201
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.97586602
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96413051
144NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94416810
145EOMES_21245162_ChIP-Seq_HESCs_Human0.92653387
146* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92212141
147ZNF274_21170338_ChIP-Seq_K562_Hela0.90619895
148NANOG_19829295_ChIP-Seq_ESCs_Human0.89946993
149SOX2_19829295_ChIP-Seq_ESCs_Human0.89946993
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87904857
151CHD1_26751641_Chip-Seq_LNCaP_Human0.86798936
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86770900
153* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85660197
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.84988503
155* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84392183
156* SMAD3_21741376_ChIP-Seq_HESCs_Human0.83621639
157TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83534374
158HTT_18923047_ChIP-ChIP_STHdh_Human0.83253182
159NANOG_16153702_ChIP-ChIP_HESCs_Human0.82379702
160* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82074319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.01993643
2MP0003303_peritoneal_inflammation3.71625676
3MP0001188_hyperpigmentation3.59861051
4MP0009379_abnormal_foot_pigmentation3.27914473
5MP0003724_increased_susceptibility_to3.12886959
6MP0003123_paternal_imprinting2.95607035
7MP0001986_abnormal_taste_sensitivity2.92037868
8MP0002735_abnormal_chemical_nociception2.75236963
9MP0004859_abnormal_synaptic_plasticity2.68531197
10MP0010234_abnormal_vibrissa_follicle2.67976094
11MP0001968_abnormal_touch/_nociception2.63024049
12MP0009046_muscle_twitch2.52858028
13MP0009745_abnormal_behavioral_response2.50752435
14MP0003195_calcinosis2.49976691
15MP0003635_abnormal_synaptic_transmissio2.42084233
16MP0002909_abnormal_adrenal_gland2.34624972
17MP0002736_abnormal_nociception_after2.29371064
18MP0002064_seizures2.24999248
19MP0000015_abnormal_ear_pigmentation2.21954187
20MP0002876_abnormal_thyroid_physiology2.18682731
21MP0008877_abnormal_DNA_methylation2.18197702
22MP0005646_abnormal_pituitary_gland2.06432501
23MP0003183_abnormal_peptide_metabolism2.05034273
24MP0003283_abnormal_digestive_organ2.03649719
25MP0003879_abnormal_hair_cell2.03110360
26MP0002572_abnormal_emotion/affect_behav2.02905262
27MP0004270_analgesia1.98958476
28MP0002063_abnormal_learning/memory/cond1.98384727
29MP0002734_abnormal_mechanical_nocicepti1.97118776
30MP0005409_darkened_coat_color1.95409615
31MP0008057_abnormal_DNA_replication1.93418002
32MP0002090_abnormal_vision1.92208923
33MP0003136_yellow_coat_color1.89261328
34MP0002272_abnormal_nervous_system1.86120845
35MP0002254_reproductive_system_inflammat1.83278332
36MP0006276_abnormal_autonomic_nervous1.80763558
37MP0009672_abnormal_birth_weight1.76522737
38MP0002067_abnormal_sensory_capabilities1.73797250
39MP0005171_absent_coat_pigmentation1.67854589
40MP0001486_abnormal_startle_reflex1.65544175
41MP0005220_abnormal_exocrine_pancreas1.59207110
42MP0001970_abnormal_pain_threshold1.57288904
43MP0005084_abnormal_gallbladder_morpholo1.57013403
44MP0003787_abnormal_imprinting1.54690585
45MP0005174_abnormal_tail_pigmentation1.50697587
46MP0001944_abnormal_pancreas_morphology1.49866787
47MP0000372_irregular_coat_pigmentation1.47573334
48MP0010386_abnormal_urinary_bladder1.47081234
49MP0001984_abnormal_olfaction1.46144276
50MP0005645_abnormal_hypothalamus_physiol1.45865375
51MP0009780_abnormal_chondrocyte_physiolo1.45470413
52MP0001501_abnormal_sleep_pattern1.44059519
53MP0005671_abnormal_response_to1.42181362
54MP0004742_abnormal_vestibular_system1.40584604
55MP0004142_abnormal_muscle_tone1.34588631
56MP0002557_abnormal_social/conspecific_i1.32583598
57MP0002148_abnormal_hypersensitivity_rea1.29843381
58MP0005423_abnormal_somatic_nervous1.27998073
59MP0002095_abnormal_skin_pigmentation1.27891507
60MP0010678_abnormal_skin_adnexa1.25761830
61MP0008569_lethality_at_weaning1.25369021
62MP0002733_abnormal_thermal_nociception1.25274164
63MP0001542_abnormal_bone_strength1.24405054
64MP0003121_genomic_imprinting1.22739776
65MP0003718_maternal_effect1.21183845
66MP0003828_pulmonary_edema1.20487877
67MP0002938_white_spotting1.17922767
68MP0002163_abnormal_gland_morphology1.15707202
69MP0001905_abnormal_dopamine_level1.14431081
70MP0000681_abnormal_thyroid_gland1.12898787
71MP0000778_abnormal_nervous_system1.12878508
72MP0003941_abnormal_skin_development1.11388509
73MP0004147_increased_porphyrin_level1.10922025
74MP0002693_abnormal_pancreas_physiology1.10128272
75MP0009703_decreased_birth_body1.09304153
76MP0002160_abnormal_reproductive_system1.04744362
77MP0001485_abnormal_pinna_reflex1.04039711
78MP0008058_abnormal_DNA_repair1.03246481
79MP0002184_abnormal_innervation1.01794718
80MP0005551_abnormal_eye_electrophysiolog1.00345917
81MP0001835_abnormal_antigen_presentation0.99991669
82MP0001963_abnormal_hearing_physiology0.98887912
83MP0005365_abnormal_bile_salt0.98518147
84MP0001177_atelectasis0.98486505
85MP0003172_abnormal_lysosome_physiology0.98213381
86MP0005332_abnormal_amino_acid0.98090138
87MP0002277_abnormal_respiratory_mucosa0.97993757
88MP0005000_abnormal_immune_tolerance0.94782658
89MP0004043_abnormal_pH_regulation0.94369572
90MP0005310_abnormal_salivary_gland0.93196941
91MP0005408_hypopigmentation0.91008641
92MP0001440_abnormal_grooming_behavior0.90967815
93MP0002882_abnormal_neuron_morphology0.89765966
94MP0004133_heterotaxia0.89490226
95MP0008875_abnormal_xenobiotic_pharmacok0.89120228
96MP0003119_abnormal_digestive_system0.88796070
97MP0004811_abnormal_neuron_physiology0.88505374
98MP0001346_abnormal_lacrimal_gland0.88438075
99MP0004924_abnormal_behavior0.88436768
100MP0005386_behavior/neurological_phenoty0.88436768
101MP0001502_abnormal_circadian_rhythm0.87228132
102MP0005636_abnormal_mineral_homeostasis0.86711319
103MP0002822_catalepsy0.85894722
104MP0010329_abnormal_lipoprotein_level0.85496617
105MP0000026_abnormal_inner_ear0.85418443
106MP0003890_abnormal_embryonic-extraembry0.85397917
107MP0001756_abnormal_urination0.85250344
108MP0002638_abnormal_pupillary_reflex0.85233273
109MP0000516_abnormal_urinary_system0.85048318
110MP0005367_renal/urinary_system_phenotyp0.85048318
111MP0005379_endocrine/exocrine_gland_phen0.84745617
112MP0008260_abnormal_autophagy0.84739571
113MP0003633_abnormal_nervous_system0.84582824
114MP0001919_abnormal_reproductive_system0.83963374
115MP0003690_abnormal_glial_cell0.83772896
116MP0002102_abnormal_ear_morphology0.83069803
117MP0002066_abnormal_motor_capabilities/c0.82882074
118MP0001663_abnormal_digestive_system0.80868390
119MP0000462_abnormal_digestive_system0.80270306
120MP0002078_abnormal_glucose_homeostasis0.79382103
121MP0000639_abnormal_adrenal_gland0.78917606
122MP0001790_abnormal_immune_system0.78876065
123MP0005387_immune_system_phenotype0.78876065
124MP0003631_nervous_system_phenotype0.78567156
125MP0000569_abnormal_digit_pigmentation0.78383588
126MP0002419_abnormal_innate_immunity0.78172168
127MP0002229_neurodegeneration0.77586196
128MP0006292_abnormal_olfactory_placode0.76674769
129MP0003436_decreased_susceptibility_to0.75846876
130MP0003953_abnormal_hormone_level0.74022467
131MP0004019_abnormal_vitamin_homeostasis0.73555600
132MP0008004_abnormal_stomach_pH0.71887277
133MP0003122_maternal_imprinting0.71127333
134MP0009785_altered_susceptibility_to0.70244774
135MP0004381_abnormal_hair_follicle0.69647850
136MP0002998_abnormal_bone_remodeling0.69640605
137MP0002138_abnormal_hepatobiliary_system0.69542218
138MP0000383_abnormal_hair_follicle0.69490749
139MP0003943_abnormal_hepatobiliary_system0.68608453
140MP0004510_myositis0.68447324
141MP0000631_abnormal_neuroendocrine_gland0.67239211
142MP0002877_abnormal_melanocyte_morpholog0.66635101
143MP0005167_abnormal_blood-brain_barrier0.66132470
144MP0005075_abnormal_melanosome_morpholog0.66070597
145MP0006082_CNS_inflammation0.66064584
146MP0008872_abnormal_physiological_respon0.65881090
147MP0002420_abnormal_adaptive_immunity0.65628803
148MP0001819_abnormal_immune_cell0.65363758
149MP0000955_abnormal_spinal_cord0.65028476
150MP0002751_abnormal_autonomic_nervous0.64813891
151MP0001731_abnormal_postnatal_growth0.64366380
152MP0001666_abnormal_nutrient_absorption0.63918019
153MP0006035_abnormal_mitochondrial_morpho0.63583459

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.41613926
2Hyperinsulinemic hypoglycemia (HP:0000825)6.34457253
3Focal motor seizures (HP:0011153)6.18377905
4Febrile seizures (HP:0002373)5.29865954
5Hypoglycemic coma (HP:0001325)5.21514263
6Pancreatic islet-cell hyperplasia (HP:0004510)5.06013304
7Atonic seizures (HP:0010819)4.85692387
8Epileptic encephalopathy (HP:0200134)4.80947889
9Abnormality of endocrine pancreas physiology (HP:0012093)4.60574911
10Abnormality of the pancreatic islet cells (HP:0006476)4.60574911
11Ketoacidosis (HP:0001993)4.58183282
12Hyperventilation (HP:0002883)4.27140032
13Symptomatic seizures (HP:0011145)4.21302886
14Hyperglycemia (HP:0003074)4.03985530
15Abnormal hair whorl (HP:0010721)3.97835914
16Hypothermia (HP:0002045)3.91707839
17Focal seizures (HP:0007359)3.50096593
18Insulin-resistant diabetes mellitus (HP:0000831)3.14084239
19Enlarged penis (HP:0000040)3.04455816
20Absence seizures (HP:0002121)3.02371099
21Abnormal pupillary function (HP:0007686)3.00510282
22Congenital sensorineural hearing impairment (HP:0008527)2.98473871
23Chronic obstructive pulmonary disease (HP:0006510)2.98425783
24Obstructive lung disease (HP:0006536)2.98425783
25Stomatitis (HP:0010280)2.94242839
26Submucous cleft hard palate (HP:0000176)2.93989797
27Obstructive sleep apnea (HP:0002870)2.88881239
28Dialeptic seizures (HP:0011146)2.86417408
29Medial flaring of the eyebrow (HP:0010747)2.82597239
30Epileptiform EEG discharges (HP:0011182)2.80709501
31Ketosis (HP:0001946)2.78508388
32Progressive cerebellar ataxia (HP:0002073)2.76685644
33Large for gestational age (HP:0001520)2.76129927
34Broad-based gait (HP:0002136)2.72634792
35Abnormality of dental color (HP:0011073)2.72002340
36Sleep apnea (HP:0010535)2.70458767
37Gaze-evoked nystagmus (HP:0000640)2.69151433
38EEG with generalized epileptiform discharges (HP:0011198)2.68028340
39Hyperthyroidism (HP:0000836)2.66306235
40Hypomagnesemia (HP:0002917)2.55221313
41Eczematoid dermatitis (HP:0000976)2.55115390
42Hypsarrhythmia (HP:0002521)2.54040431
43Neoplasm of the adrenal cortex (HP:0100641)2.53979680
44Nephrogenic diabetes insipidus (HP:0009806)2.52674452
45Progressive inability to walk (HP:0002505)2.52240395
46Gait imbalance (HP:0002141)2.45312840
47Recurrent abscess formation (HP:0002722)2.45297189
48Polyphagia (HP:0002591)2.37472819
49Generalized tonic-clonic seizures (HP:0002069)2.36803058
50Agitation (HP:0000713)2.35907703
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35484740
52Inability to walk (HP:0002540)2.34815034
53Cerebral hypomyelination (HP:0006808)2.34083926
54Congenital primary aphakia (HP:0007707)2.33682816
55Blue irides (HP:0000635)2.33201538
56Neoplasm of the adrenal gland (HP:0100631)2.31424806
57Protruding tongue (HP:0010808)2.29242098
58Abnormal eating behavior (HP:0100738)2.29103416
59Sensory axonal neuropathy (HP:0003390)2.26006719
60Hypokinesia (HP:0002375)2.24265991
61Failure to thrive in infancy (HP:0001531)2.24225592
62Generalized hypopigmentation of hair (HP:0011358)2.23934487
63Chronic bronchitis (HP:0004469)2.21537576
64Ependymoma (HP:0002888)2.17844549
65Intention tremor (HP:0002080)2.17271018
66Fair hair (HP:0002286)2.16622278
67Abnormality of methionine metabolism (HP:0010901)2.15845859
68Action tremor (HP:0002345)2.14119666
69Muscular hypotonia of the trunk (HP:0008936)2.12023536
70Thyroid-stimulating hormone excess (HP:0002925)2.11795131
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11426353
72Prominent metopic ridge (HP:0005487)2.09034144
73Curly hair (HP:0002212)2.08542517
74Absent speech (HP:0001344)2.08187014
75Dysdiadochokinesis (HP:0002075)2.06956497
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.02997105
77Severe visual impairment (HP:0001141)2.01042775
78Abnormal rod and cone electroretinograms (HP:0008323)1.99775406
79Drooling (HP:0002307)1.99625317
80Excessive salivation (HP:0003781)1.99625317
81Hemiparesis (HP:0001269)1.99410504
82Late onset (HP:0003584)1.98673137
83Recurrent bacterial skin infections (HP:0005406)1.97092493
84Hip dysplasia (HP:0001385)1.96366046
85Poor suck (HP:0002033)1.94980693
86Increased circulating renin level (HP:0000848)1.94328380
87Ankle clonus (HP:0011448)1.92069536
88CNS hypomyelination (HP:0003429)1.91888489
89Upper limb muscle weakness (HP:0003484)1.91270567
90Abnormality of the corticospinal tract (HP:0002492)1.89029828
91Myokymia (HP:0002411)1.88810476
92Distal lower limb amyotrophy (HP:0008944)1.88596563
93Hyperphosphatemia (HP:0002905)1.88224001
94Iris hypopigmentation (HP:0007730)1.88184424
95Asymmetry of the thorax (HP:0001555)1.86401308
96Abnormality of the labia minora (HP:0012880)1.85077965
97Rhinitis (HP:0012384)1.84751867
98Hepatoblastoma (HP:0002884)1.84734430
99Mutism (HP:0002300)1.83968684
100Chronic mucocutaneous candidiasis (HP:0002728)1.83404168
101Recurrent cutaneous fungal infections (HP:0011370)1.83404168
102Status epilepticus (HP:0002133)1.82761853
103Intrahepatic cholestasis (HP:0001406)1.82609859
104Abnormality of magnesium homeostasis (HP:0004921)1.81208085
105Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81110589
106Choreoathetosis (HP:0001266)1.80585494
107Decreased circulating renin level (HP:0003351)1.79944604
108Abnormality of incisor morphology (HP:0011063)1.79682851
109Diminished movement (HP:0002374)1.79516770
110Anxiety (HP:0000739)1.79459934
111Thyroid carcinoma (HP:0002890)1.79180502
112Optic disc pallor (HP:0000543)1.78615140
113Attenuation of retinal blood vessels (HP:0007843)1.74505436
114Abnormality of calcium-phosphate metabolism (HP:0100530)1.74233660
115Ulnar claw (HP:0001178)1.74127474
116Breast carcinoma (HP:0003002)1.73755411
117Bradycardia (HP:0001662)1.73667185
118Anal stenosis (HP:0002025)1.73627044
119Glioma (HP:0009733)1.72621581
120Poor coordination (HP:0002370)1.71046492
121Scanning speech (HP:0002168)1.70711964
122Meningitis (HP:0001287)1.70656321
123Alveolar cell carcinoma (HP:0006519)1.69065216
124Lower limb amyotrophy (HP:0007210)1.68870368
125Inappropriate behavior (HP:0000719)1.68655813
126Aplasia/Hypoplasia of the lens (HP:0008063)1.68107268
127Abnormality of binocular vision (HP:0011514)1.67844641
128Diplopia (HP:0000651)1.67844641
129Amblyopia (HP:0000646)1.67786219
130Prostate neoplasm (HP:0100787)1.67679358
131Fetal akinesia sequence (HP:0001989)1.66552344
132Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66519117
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.66519117
134Optic nerve hypoplasia (HP:0000609)1.66434512
135Astrocytoma (HP:0009592)1.64920040
136Abnormality of the astrocytes (HP:0100707)1.64920040
137Neuroendocrine neoplasm (HP:0100634)1.64826969
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64689713
139Homocystinuria (HP:0002156)1.64325005
140Abnormality of homocysteine metabolism (HP:0010919)1.64325005
141Megaloblastic anemia (HP:0001889)1.64318045
142Vacuolated lymphocytes (HP:0001922)1.64010240
143Absent eyebrow (HP:0002223)1.63533799
144Abnormality of salivation (HP:0100755)1.62721377
145Lower limb asymmetry (HP:0100559)1.61730033
146True hermaphroditism (HP:0010459)1.61511916
147Dyschromatopsia (HP:0007641)1.61302242
148Visual hallucinations (HP:0002367)1.61057894
149Dysmetria (HP:0001310)1.60413558
150Retrobulbar optic neuritis (HP:0100654)1.59813056
151Optic neuritis (HP:0100653)1.59813056
152Asthma (HP:0002099)1.59388515
153Hyperactive renin-angiotensin system (HP:0000841)1.59158829
154Aplasia/Hypoplasia of the fovea (HP:0008060)1.58810290
155Hypoplasia of the fovea (HP:0007750)1.58810290
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.58073068
157Absent/shortened dynein arms (HP:0200106)1.58073068
158Truncal ataxia (HP:0002078)1.57910623
159Aqueductal stenosis (HP:0002410)1.57782341
160Abnormal respiratory motile cilium physiology (HP:0012261)1.56587733
161Agammaglobulinemia (HP:0004432)1.55912755
162Pheochromocytoma (HP:0002666)1.54676454
163Abnormality of the metopic suture (HP:0005556)1.53996282
164Recurrent fungal infections (HP:0002841)1.53589744
165Urethral obstruction (HP:0000796)1.53425889
166White forelock (HP:0002211)1.52935071
167Decreased central vision (HP:0007663)1.52894263
168Tongue fasciculations (HP:0001308)1.52445217
169Narrow nasal bridge (HP:0000446)1.51662783
170Generalized myoclonic seizures (HP:0002123)1.51522490
171Abnormal respiratory epithelium morphology (HP:0012253)1.51190918
172Abnormal respiratory motile cilium morphology (HP:0005938)1.51190918
173Nephroblastoma (Wilms tumor) (HP:0002667)1.51076501
174Impaired vibratory sensation (HP:0002495)1.50901480
175Hamartoma of the eye (HP:0010568)1.49550524
176Papillary thyroid carcinoma (HP:0002895)1.48805373
177Macroorchidism (HP:0000053)1.48717955
178Neoplasm of the thyroid gland (HP:0100031)1.48265240
179Spastic tetraparesis (HP:0001285)1.47209159
180Methylmalonic acidemia (HP:0002912)1.46320529
181Hyperglycinuria (HP:0003108)1.45690209
182Nuclear cataract (HP:0100018)1.45521209
183Spastic gait (HP:0002064)1.45423390
184Torticollis (HP:0000473)1.42272862
185Impaired smooth pursuit (HP:0007772)1.42086462
186Embryonal renal neoplasm (HP:0011794)1.41954694
187Abnormal ciliary motility (HP:0012262)1.41087747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.23645966
2PRPF4B3.71900956
3FGFR23.52924739
4FES3.34797152
5INSRR3.24100311
6MKNK22.85362440
7MAP3K122.80027489
8MAP2K72.72438761
9NTRK32.23151340
10TRIM282.17540622
11AKT32.04647075
12TXK1.98618183
13MINK11.93715928
14PLK31.87738313
15SCYL21.86250480
16SIK31.78392076
17MAP3K21.77553000
18FER1.75869906
19TLK11.73216068
20TTK1.72469841
21RIPK41.68691634
22YES11.62815282
23SGK21.60336731
24MAP3K41.57255460
25CDK191.56867797
26STK38L1.50399588
27IRAK41.47543418
28PIM21.46067013
29BMPR21.45229491
30MAP3K91.44813859
31BLK1.44223219
32PLK21.42675269
33ADRBK21.42477801
34DAPK21.35502470
35TAF11.34412637
36MKNK11.28516842
37PAK61.27748598
38LATS21.27137481
39BRSK21.24816977
40PBK1.19702212
41ALK1.19432112
42PASK1.17599504
43MAP3K141.17582543
44CAMK1G1.16986671
45CDK81.16912435
46GRK71.16766406
47EIF2AK11.13451883
48NEK91.12663017
49TNIK1.12326136
50ACVR1B1.10665638
51UHMK11.10606139
52SGK4941.10180008
53SGK2231.10180008
54BMPR1B1.03952252
55TEC1.02356017
56OXSR11.01026772
57CAMK1D0.99682073
58PHKG20.98085576
59PHKG10.98085576
60STK380.97443562
61MST40.95969672
62MAPKAPK30.93270990
63MAPK130.92055372
64CAMKK20.91937781
65MAP4K20.91842489
66BRSK10.89866046
67GRK50.89086110
68PNCK0.88677436
69PINK10.86915668
70DAPK10.86603302
71SGK30.86123519
72STK30.85644555
73VRK20.84600891
74RPS6KB20.84242854
75CSK0.82888827
76ZAK0.81641493
77PRKCE0.81597858
78ADRBK10.81393113
79IRAK10.80180024
80CCNB10.76339896
81PAK30.76102922
82CSNK1G10.73537315
83CAMK2A0.72873681
84IRAK30.72257051
85MAP2K40.69933717
86CSNK1E0.69419871
87CSNK1G20.69300626
88EPHA40.69009158
89STK160.68590945
90WNK30.66901868
91EEF2K0.65694623
92LMTK20.64297900
93TSSK60.62895552
94LATS10.62710794
95MUSK0.62634392
96GRK10.62341962
97DYRK1A0.61101461
98NLK0.60520858
99CLK10.60334425
100EIF2AK30.59247647
101FRK0.59010640
102SYK0.58441869
103PRKCI0.58253130
104IRAK20.58239177
105LCK0.58163250
106MAPKAPK50.57725068
107DMPK0.57149374
108DAPK30.56661062
109BCR0.56600186
110KIT0.53555849
111CDK30.53306506
112CAMKK10.53281158
113PRKCG0.51880144
114AKT20.51688903
115STK390.51253859
116WNK10.51158867
117TAOK30.51139422
118CAMK10.51033898
119CDK90.51031759
120PLK10.50930039
121NUAK10.50680637
122SMG10.50000329
123CAMK2B0.49023907
124HCK0.45709825
125FGFR10.45672684
126STK240.45606519
127MARK10.45529350
128RPS6KB10.45508340
129PRKAA10.45105848
130CSNK1G30.44421074
131NEK60.44061389
132CDK50.43261305
133PRKD30.43160335
134STK110.43084215
135WNK40.42955475
136ATM0.42322982
137PRKDC0.41630227
138FGFR30.41143230
139LYN0.41018997
140HIPK20.40657476
141PKN10.40650284
142TNK20.40209089
143MAPK100.40086400
144CAMK2G0.40077364
145NTRK20.38802972
146RPS6KA20.38705868
147EPHA20.38372477
148FGR0.38096478
149NME10.37353613
150IKBKE0.37222507
151MAPK40.35158113
152SGK10.34028042
153PRKG10.33418448
154BRAF0.33037423
155PIK3CA0.32997269
156PTK2B0.32498535
157CAMK2D0.31681104
158EIF2AK20.29657311
159FYN0.28521074

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.53510063
2Vitamin B6 metabolism_Homo sapiens_hsa007503.40677102
3Synaptic vesicle cycle_Homo sapiens_hsa047213.37206556
4Collecting duct acid secretion_Homo sapiens_hsa049663.11480574
5Nicotine addiction_Homo sapiens_hsa050333.07814458
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26412558
7Morphine addiction_Homo sapiens_hsa050322.13851070
8Olfactory transduction_Homo sapiens_hsa047402.13402793
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06941060
10Vibrio cholerae infection_Homo sapiens_hsa051102.04230068
11Phototransduction_Homo sapiens_hsa047442.02081702
12Rheumatoid arthritis_Homo sapiens_hsa053231.98395634
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93491512
14Taste transduction_Homo sapiens_hsa047421.84339620
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78670831
16GABAergic synapse_Homo sapiens_hsa047271.78068184
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74929447
18Long-term depression_Homo sapiens_hsa047301.74351614
19Butanoate metabolism_Homo sapiens_hsa006501.74032797
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70635760
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68625760
22Circadian entrainment_Homo sapiens_hsa047131.67689710
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.64625509
24Serotonergic synapse_Homo sapiens_hsa047261.63290362
25Long-term potentiation_Homo sapiens_hsa047201.63246848
26Fatty acid elongation_Homo sapiens_hsa000621.57401927
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57106572
28Phagosome_Homo sapiens_hsa041451.55776071
29Propanoate metabolism_Homo sapiens_hsa006401.55130762
30Dopaminergic synapse_Homo sapiens_hsa047281.52196292
31Protein export_Homo sapiens_hsa030601.51839009
32Glutamatergic synapse_Homo sapiens_hsa047241.50722222
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49887850
34Amphetamine addiction_Homo sapiens_hsa050311.41817988
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41013482
36Renin secretion_Homo sapiens_hsa049241.39891406
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39886832
38Cholinergic synapse_Homo sapiens_hsa047251.29019676
39Fatty acid metabolism_Homo sapiens_hsa012121.27428620
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24984120
41beta-Alanine metabolism_Homo sapiens_hsa004101.23116392
42Type I diabetes mellitus_Homo sapiens_hsa049401.22600664
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22022344
44Salivary secretion_Homo sapiens_hsa049701.19424244
45Calcium signaling pathway_Homo sapiens_hsa040201.15338711
46Selenocompound metabolism_Homo sapiens_hsa004501.14525203
47Insulin secretion_Homo sapiens_hsa049111.12899537
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10756721
49Oocyte meiosis_Homo sapiens_hsa041141.07163575
50Non-homologous end-joining_Homo sapiens_hsa034501.06910702
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06337973
52Gastric acid secretion_Homo sapiens_hsa049711.03725577
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03210981
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01709392
55ErbB signaling pathway_Homo sapiens_hsa040121.01678620
56Thyroid hormone synthesis_Homo sapiens_hsa049180.98810621
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.98512676
58Peroxisome_Homo sapiens_hsa041460.98338157
59Allograft rejection_Homo sapiens_hsa053300.98143068
60Histidine metabolism_Homo sapiens_hsa003400.98017749
61Primary immunodeficiency_Homo sapiens_hsa053400.97993693
62Melanoma_Homo sapiens_hsa052180.97077593
63Pyruvate metabolism_Homo sapiens_hsa006200.96709912
64Oxidative phosphorylation_Homo sapiens_hsa001900.96359864
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94978991
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93768393
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93397031
68Other glycan degradation_Homo sapiens_hsa005110.92853763
69Glucagon signaling pathway_Homo sapiens_hsa049220.91023512
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90390610
71cAMP signaling pathway_Homo sapiens_hsa040240.88196758
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87669550
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87529283
74Oxytocin signaling pathway_Homo sapiens_hsa049210.87261452
75Fatty acid biosynthesis_Homo sapiens_hsa000610.86627997
76Tuberculosis_Homo sapiens_hsa051520.86327411
77Sphingolipid metabolism_Homo sapiens_hsa006000.85121151
78Autoimmune thyroid disease_Homo sapiens_hsa053200.84580478
79Chemokine signaling pathway_Homo sapiens_hsa040620.83729245
80Arginine biosynthesis_Homo sapiens_hsa002200.83330296
81Fatty acid degradation_Homo sapiens_hsa000710.83198440
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82109993
83Hematopoietic cell lineage_Homo sapiens_hsa046400.82014845
84Carbon metabolism_Homo sapiens_hsa012000.81400596
85Graft-versus-host disease_Homo sapiens_hsa053320.81075114
86Axon guidance_Homo sapiens_hsa043600.80207585
87Salmonella infection_Homo sapiens_hsa051320.79986915
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79555333
89Tight junction_Homo sapiens_hsa045300.79122457
90Glioma_Homo sapiens_hsa052140.77934197
91Vitamin digestion and absorption_Homo sapiens_hsa049770.76654669
92Glutathione metabolism_Homo sapiens_hsa004800.76264113
93Nitrogen metabolism_Homo sapiens_hsa009100.76059024
94Arginine and proline metabolism_Homo sapiens_hsa003300.75717933
95Osteoclast differentiation_Homo sapiens_hsa043800.75262744
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.74700555
97Leishmaniasis_Homo sapiens_hsa051400.73354687
98T cell receptor signaling pathway_Homo sapiens_hsa046600.73198422
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73182126
100Malaria_Homo sapiens_hsa051440.72999796
101Ras signaling pathway_Homo sapiens_hsa040140.71319658
102Bile secretion_Homo sapiens_hsa049760.71206209
103Cocaine addiction_Homo sapiens_hsa050300.70036251
104mTOR signaling pathway_Homo sapiens_hsa041500.68754627
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.67432297
106Pancreatic secretion_Homo sapiens_hsa049720.66915120
107One carbon pool by folate_Homo sapiens_hsa006700.66145013
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.65515061
109Folate biosynthesis_Homo sapiens_hsa007900.65163530
110GnRH signaling pathway_Homo sapiens_hsa049120.64978737
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63905753
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63190883
113MAPK signaling pathway_Homo sapiens_hsa040100.62744532
114Measles_Homo sapiens_hsa051620.62638217
115ABC transporters_Homo sapiens_hsa020100.62603056
116Mineral absorption_Homo sapiens_hsa049780.61665240
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61419091
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61293574
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60833705
120Pertussis_Homo sapiens_hsa051330.60223972
121Regulation of autophagy_Homo sapiens_hsa041400.60111309
122Lysine degradation_Homo sapiens_hsa003100.59451003
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58336726
124Steroid biosynthesis_Homo sapiens_hsa001000.58146478
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57928099
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57248073
127Ovarian steroidogenesis_Homo sapiens_hsa049130.57137082
128Melanogenesis_Homo sapiens_hsa049160.56967263
129Prolactin signaling pathway_Homo sapiens_hsa049170.56780985
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56490581
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56388647
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56150989
133Biosynthesis of amino acids_Homo sapiens_hsa012300.55827005
134Tryptophan metabolism_Homo sapiens_hsa003800.55138307
135Endocytosis_Homo sapiens_hsa041440.55137983
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53848025
137AMPK signaling pathway_Homo sapiens_hsa041520.53305725
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53257242
139N-Glycan biosynthesis_Homo sapiens_hsa005100.52856345
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.50490033
141Alzheimers disease_Homo sapiens_hsa050100.50431177
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49349586
143Estrogen signaling pathway_Homo sapiens_hsa049150.49341077
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49158621
145Hepatitis C_Homo sapiens_hsa051600.48833742
146Lysosome_Homo sapiens_hsa041420.47711876
147Asthma_Homo sapiens_hsa053100.47679297
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47652226
149Gap junction_Homo sapiens_hsa045400.47652025
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.47367027
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47276780
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46579279
153Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45901089
154Purine metabolism_Homo sapiens_hsa002300.45839603
155Inositol phosphate metabolism_Homo sapiens_hsa005620.45353590
156Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44776209
157Metabolic pathways_Homo sapiens_hsa011000.44559877
158Circadian rhythm_Homo sapiens_hsa047100.43912078
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43301557
160Type II diabetes mellitus_Homo sapiens_hsa049300.42143825
161Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41956835
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41742894

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